WO2013031749A1 - Bactéries lactiques permettant de favoriser l'activité physique - Google Patents

Bactéries lactiques permettant de favoriser l'activité physique Download PDF

Info

Publication number
WO2013031749A1
WO2013031749A1 PCT/JP2012/071644 JP2012071644W WO2013031749A1 WO 2013031749 A1 WO2013031749 A1 WO 2013031749A1 JP 2012071644 W JP2012071644 W JP 2012071644W WO 2013031749 A1 WO2013031749 A1 WO 2013031749A1
Authority
WO
WIPO (PCT)
Prior art keywords
physical activity
product
lactobacillus gasseri
lactic acid
promoting
Prior art date
Application number
PCT/JP2012/071644
Other languages
English (en)
Japanese (ja)
Inventor
暢子 神野
昌士 長田
Original Assignee
株式会社明治
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 株式会社明治 filed Critical 株式会社明治
Priority to CN201280041977.7A priority Critical patent/CN103764155B/zh
Priority to SG11201400196UA priority patent/SG11201400196UA/en
Publication of WO2013031749A1 publication Critical patent/WO2013031749A1/fr

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A61P21/06—Anabolic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00—Lactic or propionic acid bacteria
    • A23V2400/11—Lactobacillus
    • A23V2400/145—Gasseri

Definitions

  • the present invention relates to a physical activity promoter containing Lactobacillus gasseri as an active ingredient, or a food composition for promoting physical activity containing these.
  • Non-patent Document 1 Non-patent Document 1
  • the intestinal flora and nervous system are also interactively related. For example, if you ingest microorganisms with probiotic function, they act on the intestinal flora, It is thought that the effect on the brain can be expected by acting on the central system while making the intestinal flora healthy.
  • Patent Document 1 Japanese Patent Application Laid-Open No. 2004-269361
  • Patent Document 2 WO 2007/023896
  • GABA produced by fermentation method from bacteria of Lactobacillus hihilgardi K-3 strain has been found to promote GH secretion, thereby enhancing muscle, skeletal enhancement, fat reduction, skin rejuvenation, immunity It is disclosed that a physiological effect such as recovery of the skin can be expected.
  • Patent Document 2 discloses that fermented milk fermented with Lactobacillus helveticus koji CM4 strain has (a) antioxidant enzyme expression action, (b) heat shock protein expression action, (c) neutrophil chemotaxis and It has been disclosed that it has an action to suppress tissue infiltration and is effective in suppressing delayed myalgia.
  • the present invention has been made in view of the above situation, and the problem to be solved by the present invention is that a human activity-inducing agent containing lactic acid bacteria derived from human intestines and / or processed products of the lactic acid bacteria as active ingredients, or It is providing the food composition for physical activity promotion containing this.
  • the present inventors have confirmed that ingesting Lactobacillus gasseri OLL2809 and its fermented and processed products promotes physical activity, specifically increases activity and increases muscle mass. This led to the completion of the present invention.
  • the present invention relates to the following [1] to [11].
  • a physical activity promoter comprising Lactobacillus gasseri as an active ingredient.
  • Processed Lactobacillus gasseri culture concentrate, pasted product, spray dried product, freeze dried product, vacuum dried product, drum dried product, liquid product, diluted product, crushed product
  • the physical activity promoter which uses the processed product of lactic acid bacteria which is at least one chosen from these as an active ingredient.
  • a food composition for promoting physical activity comprising an effective amount of the physical activity promoter according to any one of [1] to [5].
  • [8] The use according to [7], wherein the food composition for promoting physical activity is infant formula, infant formula, food for nursing women, health functional food, food for the sick, or fermented milk .
  • a method for promoting physical activity comprising administering Lactobacillus gasseri or a processed product thereof.
  • At least one selected from Lactobacillus gasseri or its culture, concentrate, pasted product, spray dried product, freeze dried product, vacuum dried product, drum dried product, liquid product, diluted product, and crushed product A method for producing a food composition for promoting physical activity, characterized by using a processed product.
  • Lactobacillus gasseri for use in a method for promoting physical activity, or a culture, concentrate, pasted product, spray-dried product, freeze-dried product, vacuum-dried product, drum-dried product, liquid product, or diluted product thereof A processed product that is at least one selected from crushed materials.
  • Lactobacillus gasseri OLL2809 (Lactobacillus gasseri OLL2809, accession number: NITE BP-72) was administered for 26 days, and the mouse gastrocnemius muscle was extracted. It is a figure which shows the value which remove
  • the present invention provides a physical activity promoter containing lactic acid bacteria as an active ingredient.
  • the physical activity promoter of the present invention contains Lactobacillus gasseri as lactic acid bacteria. Any Lactobacillus gasseri can be used as long as it has an effect of promoting physical activity, but a type with high survival after administration into the body is preferred. Specific examples of Lactobacillus gasseri that can be used in the present invention include Lactobacillus gasseri OLL2809 strain.
  • the Lactobacillus gasseri OLL2809 has been shown to have the effect of inducing IL-12 production from immunocompetent cells and inducing the Th1 / Th2 balance to the Th1 side by oral administration to various allergy model animals. (International Publication WO2006 / 093022). In International Publication No.
  • WO2006 / 093022 from Lactobacillus lactic acid bacteria 273 strain isolated independently from human adult feces, (1) gastric acid / bile acid resistance test, (2) IL-12 production promoting effect on spleen cells derived from mice, And Th1 / Th2 balance improvement effect evaluation test, (3) Antigen specific IgE production suppression effect evaluation test induced by intraperitoneal administration of ovalbumin to BALB / c mice, (4) Food antigen in C57BL / 6N mice Antigen-specific IgE production inhibitory effect evaluation test induced by orally administering (casein), (5) Natural killer cell activation ability evaluation test, (6) Spleen cells from mice immunized with ovalbumin IL-12 production promotion effect evaluation test and Th1 / Th2 balance improvement effect evaluation test for mesenteric lymph node cells, (7) Eosinophilia suppression ability evaluation test induced by cedar pollen Investigated using, it shows a high activity in any of the items.
  • the subject administered or ingested the Lactobacillus gasseri OLL2809 promotes physical activity, and the use of the lactic acid bacteria is effective for promoting physical activity. It has become possible to provide a physical activity promoter or a food composition for promoting physical activity containing the physical activity promoter.
  • the present inventors deposited this strain with the Patent Microorganism Deposit Center, National Institute of Technology and Evaluation. The contents specifying the deposit are described below.
  • the present inventors deposited the Lactobacillus gasseri OLL2809 strain at the Patent Microorganism Depositary Center for Product Evaluation Technology Foundation.
  • the contents specifying the deposit are described below.
  • (3) Accession number: NITE BP-72 (4) Display for identification: Lactobacillus gasseri OLL2809 (5) Date of original deposit: February 1, 2005 (6) Date of transfer to deposit under the Budapest Treaty: January 18, 2006
  • Lactobacillus gasseri OLL2809 strain (Accession number: NITE BP-72) is a Gram-positive gonococcus, and the colony form on Lactobacilli MRS Agar, Difco is round, pale yellow, and flat.
  • Physiological characteristics include homolactic fermentation, growth at 45 ° C., fermentability to glucose, mannose, fructose, galactose, sucrose, cellobiose, lactose, trehalose.
  • Lactobacillus gasseri OLL2809 (Accession number: NITE BP-72)
  • a medium usually used for lactic acid bacteria is used. That is, any medium can be used as long as it contains a nitrogen source, an inorganic substance and other nutrients in addition to the main carbon source.
  • the carbon source lactose, glucose, sucrose, fructose, starch hydrolyzate, waste molasses and the like can be used according to the assimilation ability of the bacteria used.
  • the nitrogen source organic nitrogen-containing substances such as casein hydrolyzate, whey protein hydrolyzate, and soy protein hydrolyzate can be used.
  • meat extract, fish extract, yeast extract and the like are used as growth promoters.
  • Cultivation is preferably performed under anaerobic conditions, but may be performed under microaerobic conditions such as liquid stationary culture that is usually used.
  • anaerobic culture a known method such as a method of culturing under a nitrogen gas layer can be applied, but other methods may be used.
  • the culture temperature is preferably 30 to 40 ° C. However, other temperature conditions may be used as long as the temperature allows the bacteria to grow.
  • the pH of the medium during the culture is preferably maintained at 6.0 to 7.0, but may be other pH conditions as long as the bacteria grow. It can also be cultured under batch culture conditions.
  • the culture time is usually preferably 10 to 24 hours, but may be any other culture time as long as the bacteria can grow.
  • Lactobacillus gasseri that can be used in the present invention is also a gram-positive bacillus and other physiological characteristics exhibit the same characteristics as Lactobacillus gasseri OLL2809. Those skilled in the art can isolate such Lactobacillus ⁇ gasseri from human feces and the like based on physiological characteristics.
  • “physical activity is promoted (physical activity is promoted)” is not particularly limited in its aspect, but specifically, “(physical) activity amount in the administration subject or ingestion subject”.
  • “(physical) activity amount in the administration subject or ingestion subject” is an embodiment in which “increases” or “increases muscle mass”.
  • promoting physical activity also means reducing the morbidity and mortality of ischemic heart disease, hypertension, diabetes, obesity, osteoporosis, colon cancer and the like.
  • promoting physical activity has an effect on improving mental health and quality of life (QOL). That is, in the present invention, “promoting physical activity” also means improving mental state or improving quality of life.
  • promoting physical activity also means reducing body weight or reducing visceral fat mass.
  • promoting physical activity also means maintaining the muscle, bone, joint, and brain functions by suppressing the decrease in the amount of activity in the elderly with a decreased amount of physical activity.
  • the physical activity promoting effect is compared between the administration group (ingestion group) and the non-administration group (non-ingestion group) of the average value of (physical) activity in the administration subject or ingestion subject. This can be confirmed.
  • the amount of physical activity can be measured by measuring the amount of action in the dark period, which is the active period of the mouse.
  • the difference in the amount of behavior between the reference week and the next week is defined as the “behavior amount change amount”.
  • the degree of physical activity promotion effect can be confirmed.
  • the “behavioral change rate” is greater than 0%, the administered lactic acid bacteria can be recognized as having an effect of promoting physical activity.
  • the range of the “activity change rate” that is improved by the physical activity promoting effect is preferably 1% or more, more preferably 5% or more, and even more preferably 10% or more.
  • the range of the change rate can be exemplified.
  • the effect of promoting physical activity is confirmed by comparing muscle mass, body weight, or visceral fat mass between the administration group (ingestion group) and the non-administration group (non-ingestion group) in the administration subject or ingestion subject. be able to.
  • the part where the muscle mass is measured may be any part such as an extremity (upper arm, forearm, thigh, lower leg) or trunk.
  • the weight (weight) of the muscle mass of a specific muscle site for example, gastrocnemius
  • the administration group (intake group) And the muscle mass of the non-administration group (non-ingestion group).
  • the administered lactic acid bacteria can be identified as having an effect of promoting physical activity.
  • Mets metabolic equivalent
  • exercise an index
  • Mets-time (Ex: exercise) multiplied by exercise time.
  • the amount of physical activity can be measured according to the time spent and the type of physical activity.
  • Exercise (Ex) is a unit that expresses the amount of physical activity indicated by “intensity of physical activity [METs] ⁇ duration of physical activity [hours]”. This unit includes body weight (Kg) and reference value (1.05). Etc.) can be calculated to calculate calorie consumption (kcal). The physical activity promotion effect can also be confirmed by comparing the calorie consumption calculated by the above method.
  • the physical activity promoter of the present invention can contain the above-mentioned Lactobacillus gassei in various states.
  • Lactobacillus gassei for example, lactic acid bacteria suspension, lactic acid bacteria culture (cells, culture supernatant (including medium components)), lactic acid bacteria fermentation product (Lactic acid bacteria beverage, sour milk, yogurt, etc.) and the like.
  • the physical activity promoter of the present invention may contain the above Lactobacillus gasseri as it is, or may be contained as a processed product of lactic acid bacteria obtained by subjecting Lactobacillus gasseri to some kind of treatment.
  • processed lactic acid bacteria used in the physical activity promoter of the present invention include lactic acid bacteria, lactic acid bacteria-containing products, concentrated fermented milk, pasted products, dried products (spray dried products, freeze dried products, vacuum dried products, drum dried products) And at least one selected from the group consisting of a liquid, a diluted product, and a crushed product.
  • lactic acid bacteria live cells, wet bacteria, dry bacteria, and the like can be used as appropriate.
  • It may be dead cells subjected to sterilization, that is, heat sterilization treatment, radiation sterilization treatment, or crushing treatment. It can also be added to pharmaceuticals and / or foods and drinks having biological standards such as powdered milk, and can be applied to various pharmaceuticals and / or foods and drinks regardless of the form of the pharmaceuticals and / or foods and drinks.
  • the physical activity promoter of the present invention is orally administered alone or mixed with other components that can be usually used in pharmaceuticals and foods, or by using in combination with other compounds or microorganisms having physical activity promoting activity, Effective in promoting physical activity in humans and animals.
  • the lactic acid bacteria culture solution after completion of the culture can be used as it is or concentrated to obtain a concentrate, and the concentrate can be further dried.
  • the cell concentration is not particularly limited, but it is preferably 4 ⁇ 10 10 cells / g or more for the concentrate and 5 ⁇ 10 11 cells / g or more for the dried product.
  • the amount of the physical activity promoter of the present invention added to a pharmaceutical product or food or drink varies depending on the form, dosage form, symptom, body weight, use, etc., and is not particularly limited. However, if it is intentionally mentioned, 0.001 to 100% (w / w) It can be blended at a content of preferably 0.01 to 100% (w / w), more preferably 0.1 to 100% (w / w).
  • the daily intake of the drug or food and drink of the physical activity promoter of the present invention varies depending on age, symptoms, body weight, use, etc., and is not particularly limited. However, if it is intentionally taken, 0.1 to 10000 mg / kg body weight should be taken. Preferably, 0.1 to 1000 mg / kg body weight can be ingested.
  • the physical activity promoter of the present invention can be used in the form of any medicine or food and drink.
  • various physical activities are promoted by direct administration as a pharmaceutical, or by direct intake as a special-purpose food such as a food for specified health use or a nutritionally functional food.
  • various foods and drinks milk, processed milk, milk drinks, soft drinks, fermented milk, yogurt, cheese, bread, biscuits, crackers, pizza crust, ice cream, candy, gummi, gum, prepared milk powder, liquid food, sick people Foods for infants, infant milk powders, lactating milk powders, nutritional foods, etc.
  • the food and drink containing the physical activity promoter of the present invention can be used by mixing water, protein, carbohydrates, lipids, vitamins, minerals, organic acids, organic bases, fruit juices, flavors and the like.
  • the protein include whole milk powder, skim milk powder, partially skim milk powder, casein, whey powder, whey protein, whey protein concentrate, whey protein isolate, ⁇ -casein, ⁇ -casein, ⁇ -casein, ⁇ -lactoglobulin , ⁇ -lactalbumin, lactoferrin, soy protein, egg protein, meat protein and other animal and vegetable proteins, hydrolysates thereof, butter, whey minerals, cream, whey, non-protein nitrogen, sialic acid, phospholipid, lactose, etc.
  • Examples include saccharides, processed starch (in addition to text phosphorus, soluble starch, British starch, oxidized starch, starch ester, starch ether, etc.), dietary fiber, and the like.
  • Examples of the lipid include animal oils such as lard, fish oil, etc., fractionated oils, hydrogenated oil, transesterified oil, etc .; palm oil, safflower oil, corn oil, rapeseed oil, coconut oil, fractionated oils thereof, Examples include vegetable oils such as hydrogenated oils and transesterified oils.
  • vitamins include vitamin A, carotene, vitamin B group, vitamin C, vitamin D group, vitamin E, vitamin K group, vitamin P, vitamin Q, niacin, nicotinic acid, pantothenic acid, biotin, inositol, choline.
  • minerals include calcium, potassium, magnesium, sodium, copper, iron, manganese, zinc, and selenium.
  • organic acid include malic acid, citric acid, lactic acid, and tartaric acid. In the production of foods and drinks containing the physical activity promoter of the present invention, these components may be either synthetic products or naturally derived products, and / or foods containing a large amount thereof may be used as raw materials. Good. Moreover, these components can be used in combination of 2 or more types.
  • the production method can be carried out by methods well known to those skilled in the art. If it is an expert, the process which mixes the Lactobacillus gasseri microbial cell or processed material of the present invention with other ingredients, a molding process, a sterilization process, a fermentation process, a baking process, a drying process, a cooling process, a granulation process, a packaging process, etc. It is possible to make a desired food or drug by appropriately combining the above.
  • a desired dairy product can be manufactured by a method well-known to those skilled in the art.
  • the process of preparing the starter using the Lactobacillus gasseri of the present invention the process of culturing the starter in addition to the pretreated milk, the cooling process, the flavoring process, the filling process, etc. Yogurt can be manufactured.
  • a process of adding Lactobacillus gasseri of the present invention as a starter to milk that has been pretreated such as sterilization and lactic acid fermentation a process of adding rennet to produce a cheese curd, a card cutting process, whey It can be manufactured through a discharging process, a salting process, an aging process, and the like.
  • other Lactobacillus gasseri may be used as a starter instead of Lactobacillus gasseri of the present invention, and the Lactobacillus gasseri cell or processed product of the present invention may be added during the manufacturing process.
  • the physical activity promoter of the present invention When used as a pharmaceutical, it can be administered in various forms. Examples of the form include oral administration using tablets, capsules, granules, powders, syrups and the like. These various preparations can be generally used in the pharmaceutical preparation technical field such as excipients, binders, disintegrants, lubricants, flavoring agents, solubilizers, suspension agents, coating agents, etc. as main ingredients according to conventional methods. It can be formulated using known adjuvants. In addition, by making an enteric preparation by a method well known to those skilled in the art, the physical activity promoter of the present invention can be more efficiently delivered to the intestine without being affected by gastric acid. In addition, all prior art documents cited in the present specification are incorporated herein by reference.
  • Lactobacillus gasseri OLL2809 (Lactobacillus gasseri OLL2809, accession number: NITE BP-72) will be described in detail.
  • the present invention is not limited to the following examples. [Example 1]
  • mice Six weeks old BALB / c male mice were acclimated for one week and then subjected to experiments. One week before the start of the experiment, in order to reduce the variation in the measured values, grouping was performed based on the amount of behavior. Each group consisted of 8 animals per group. From the start of the experiment, the lactic acid bacteria Lactobacillus gasseri OLL2809 dead cells were administered at 2 mg / body / day (1x10 8 to 5 x10 8 per 2 mg), or distilled water was administered orally for 25 days The amount of behavior in the dark period, which is the active period of mice, was measured. The amount of behavior was measured twice a week for 24 hours with an infrared behavior amount measuring device (manufactured by Shin Factory).
  • the amount of behavior is the change rate (%) between the second week of administration and the third week of administration for the second week (average value of two measurements) and the third week (average value of two measurements). ).
  • Lactobacillus gasseri promotes physical activity of the administration target.
  • the present technology is not limited to Lactobacillus gasseri shown in the Examples, and is likely to be widely applicable to Lactobacillus gasseri lactic acid bacteria species.
  • the physical activity promoter of the present invention increases the amount of activity of the administered subject and increases its muscle mass, as confirmed in the examples described later. Therefore, according to the present invention, it is possible to provide a new physical activity promoter or a food composition for promoting physical activity containing the same, which is effective for health maintenance and stress relief including prevention of lifestyle-related diseases. It became possible.
  • the present invention supports an increase in the amount of activity of a person who lacks exercise, thereby continuing exercise and realizing an improvement in QOL.
  • health maintenance effects such as maintenance of muscle, bone, joint, and brain functions by suppressing the decrease in activity can be expected.
  • the food composition for promoting physical activity of the present invention can be used as an exercise starting food or an exercise continuation food for elderly people who are recommended to exercise moderately and moderately by young people who want to continue exercise in the industry.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Neurology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Endocrinology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Food Science & Technology (AREA)
  • Polymers & Plastics (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

La présente invention a pour objectif de proposer un élément favorisant l'activité physique qui comprend des bactéries lactiques de l'intestin humain et/ou un produit traité de ces bactéries lactiques, ou une composition de produit alimentaire pour favoriser une activité physique contenant lesdites bactéries. Afin d'atteindre cet objectif, les présents inventeurs ont administré des bactéries lactiques Lactobacillus Gasseri OLL2809 éliminées à des souris, et ont ensuite découvert qu'en plus de l'effet d'inhibition de l'infiltration éosinophile, l'effet d'augmentation de la quantité d'action était également présent. En d'autres termes, les présents inventeurs ont perfectionné la présente invention en ayant découvert que l'ingestion de Lactobacillus Gasseri OLL2809 ou d'un produit fermenté/produit dérivé de celles-ci favorise l'activité physique, et augmente de manière spécifique la quantité d'activité ainsi que la masse musculaire.
PCT/JP2012/071644 2011-08-29 2012-08-28 Bactéries lactiques permettant de favoriser l'activité physique WO2013031749A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN201280041977.7A CN103764155B (zh) 2011-08-29 2012-08-28 促进身体活动的乳酸菌
SG11201400196UA SG11201400196UA (en) 2011-08-29 2012-08-28 Lactic acid bacteria for promoting physical activity

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011-185777 2011-08-29
JP2011185777A JP2013047192A (ja) 2011-08-29 2011-08-29 身体活動を促進させる乳酸菌

Publications (1)

Publication Number Publication Date
WO2013031749A1 true WO2013031749A1 (fr) 2013-03-07

Family

ID=47756234

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2012/071644 WO2013031749A1 (fr) 2011-08-29 2012-08-28 Bactéries lactiques permettant de favoriser l'activité physique

Country Status (4)

Country Link
JP (1) JP2013047192A (fr)
CN (1) CN103764155B (fr)
SG (1) SG11201400196UA (fr)
WO (1) WO2013031749A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014132982A1 (fr) * 2013-02-27 2014-09-04 株式会社明治 Agent anti-stress
JP2014208637A (ja) * 2013-03-28 2014-11-06 学校法人立命館 筋肉増強剤
WO2018003900A1 (fr) 2016-06-30 2018-01-04 アサヒグループホールディングス株式会社 Composition pour une utilisation dans l'amélioration de l'état nutritionnel
WO2019230957A1 (fr) * 2018-06-01 2019-12-05 雪印メグミルク株式会社 Composition pour accélérer la réparation musculaire
WO2021112041A1 (fr) * 2019-12-02 2021-06-10 雪印メグミルク株式会社 Agent de renforcement osseux

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015056234A1 (fr) * 2013-10-17 2015-04-23 Koninklijke Philips N.V. Systèmes et procédés pour favoriser l'activité physique
JP6757190B2 (ja) * 2016-06-29 2020-09-16 株式会社ヤクルト本社 危機回避能力低下抑制剤
EP3978075A4 (fr) 2019-06-03 2023-07-12 Asahi Group Holdings, Ltd. Agent d'amélioration de la capacité de marche
JP7333732B2 (ja) 2019-09-06 2023-08-25 森永乳業株式会社 筋肉量及び／又は筋力の維持、或いは筋肉量及び／又は筋力の低下抑制用組成物、並びに、該組成物を用いた医薬品組成物及び飲食品組成物
WO2022215568A1 (fr) * 2021-04-08 2022-10-13 雪印メグミルク株式会社 Agent favorisant la synthèse musculaire et agent favorisant la phosphorylation de la protéine p70s6k
WO2023249423A1 (fr) * 2022-06-22 2023-12-28 (주)에이스바이옴 Composition comprenant lactobacillus gasseri pour prévenir et traiter la sarcopénie

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004305128A (ja) * 2003-04-08 2004-11-04 Meiji Shiryo Kk 飼料組成物
WO2006093022A1 (fr) * 2005-03-03 2006-09-08 Meiji Dairies Corporation Agent modulant la fonction immune
JP2009044976A (ja) * 2007-08-16 2009-03-05 Meiji Shiryo Kk 動物の体型改良飼養システム
JP2009242431A (ja) * 2009-07-17 2009-10-22 Snow Brand Milk Prod Co Ltd 加齢に伴う代謝異常症の予防・改善・治療剤

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004305128A (ja) * 2003-04-08 2004-11-04 Meiji Shiryo Kk 飼料組成物
WO2006093022A1 (fr) * 2005-03-03 2006-09-08 Meiji Dairies Corporation Agent modulant la fonction immune
JP2009044976A (ja) * 2007-08-16 2009-03-05 Meiji Shiryo Kk 動物の体型改良飼養システム
JP2009242431A (ja) * 2009-07-17 2009-10-22 Snow Brand Milk Prod Co Ltd 加齢に伴う代謝異常症の予防・改善・治療剤

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014132982A1 (fr) * 2013-02-27 2014-09-04 株式会社明治 Agent anti-stress
JP2014208637A (ja) * 2013-03-28 2014-11-06 学校法人立命館 筋肉増強剤
WO2018003900A1 (fr) 2016-06-30 2018-01-04 アサヒグループホールディングス株式会社 Composition pour une utilisation dans l'amélioration de l'état nutritionnel
JPWO2018003900A1 (ja) * 2016-06-30 2019-05-16 アサヒグループホールディングス株式会社 栄養状態改善に使用するための組成物
WO2019230957A1 (fr) * 2018-06-01 2019-12-05 雪印メグミルク株式会社 Composition pour accélérer la réparation musculaire
JPWO2019230957A1 (ja) * 2018-06-01 2021-11-04 雪印メグミルク株式会社 筋修復促進用組成物
JP7488182B2 (ja) 2018-06-01 2024-05-21 雪印メグミルク株式会社 筋修復促進用組成物
WO2021112041A1 (fr) * 2019-12-02 2021-06-10 雪印メグミルク株式会社 Agent de renforcement osseux

Also Published As

Publication number Publication date
CN103764155A (zh) 2014-04-30
SG11201400196UA (en) 2014-10-30
JP2013047192A (ja) 2013-03-07
CN103764155B (zh) 2017-07-25

Similar Documents

Publication Publication Date Title
WO2013031749A1 (fr) Bactéries lactiques permettant de favoriser l'activité physique
JP6329125B2 (ja) ストレス軽減剤
TWI359668B (fr)
KR101355770B1 (ko) 면역조절 활성이 높은 유산균의 배양법
CN102791849B (zh) 含乳酸菌制剂
KR101184898B1 (ko) 염증성 장질환 예방 및/또는 치료제
JP7088829B2 (ja) 新生児向けの脳機能改善用組成物
JP5527690B2 (ja) 免疫調節性機能誘導剤及び食品組成物
MX2008009726A (es) Uso de microorganismos probioticos para el tratamiento y prevencion de la obesidad y trastornos relacionados.
JP2006273852A (ja) ビフィズス菌を有効成分とするアレルギー予防および／または治療剤
JPWO2017130859A1 (ja) 神経細胞死抑制剤
JP6923883B2 (ja) 栄養状態改善に使用するための組成物
WO2008029505A1 (fr) Agent d'accélération de l'accroissement et/ou la prévention de diminution dans le niveau d'adiponectine dans le sang, et inhibiteur de l'accumulation de graisse viscérale
JP6849972B2 (ja) 乳児向けの感染防御剤
JP6823302B2 (ja) 乳児向けの抗アレルギー剤
KR20100119875A (ko) 아디포넥틴의 분비 촉진 및/또는 감소 억제용 제제
JP5229977B2 (ja) 血中アディポネクチン濃度増加促進及び／又は減少抑制剤
JP6150312B2 (ja) 身体活動を促進させる乳酸菌
JP6894096B2 (ja) 軟骨再生促進用組成物
JP2021534745A (ja) 改善された人間用食品
CN111201026A (zh) 具有癌性恶病质抑制作用的发酵乳和多糖类
JP2004315477A (ja) 骨吸収抑制剤
CN109475583B (zh) 用于抑制红斑产生的组合物及其使用方法和制造方法、抑制红斑产生的方法、乳酸菌产物
JP7402629B2 (ja) プロピオン酸菌発酵物含有組成物
US20200246400A1 (en) Growth-stimulating lactobacillus strains

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 12826968

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 12826968

Country of ref document: EP

Kind code of ref document: A1