WO2013028966A2 - Activated carbon containing wound dressing - Google Patents

Activated carbon containing wound dressing Download PDF

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Publication number
WO2013028966A2
WO2013028966A2 PCT/US2012/052246 US2012052246W WO2013028966A2 WO 2013028966 A2 WO2013028966 A2 WO 2013028966A2 US 2012052246 W US2012052246 W US 2012052246W WO 2013028966 A2 WO2013028966 A2 WO 2013028966A2
Authority
WO
WIPO (PCT)
Prior art keywords
material layer
activated carbon
wound dressing
wound
layer
Prior art date
Application number
PCT/US2012/052246
Other languages
English (en)
French (fr)
Other versions
WO2013028966A3 (en
Inventor
Jack Elliot TAYLOR
Wayne LAVOCAH
Original Assignee
Calgon Carbon Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Calgon Carbon Corporation filed Critical Calgon Carbon Corporation
Priority to JP2014527324A priority Critical patent/JP2014525291A/ja
Priority to CA2845892A priority patent/CA2845892A1/en
Priority to EP12825640.1A priority patent/EP2747723A4/en
Priority to KR1020147007582A priority patent/KR20140054331A/ko
Priority to RU2014110970/12A priority patent/RU2014110970A/ru
Priority to BR112014004287A priority patent/BR112014004287A2/pt
Priority to CN201280052413.3A priority patent/CN103889379A/zh
Publication of WO2013028966A2 publication Critical patent/WO2013028966A2/en
Publication of WO2013028966A3 publication Critical patent/WO2013028966A3/en

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Classifications

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    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/18—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing inorganic materials
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    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0203—Adhesive bandages or dressings with fluid retention members
    • A61F13/0206—Adhesive bandages or dressings with fluid retention members with absorbent fibrous layers, e.g. woven or non-woven absorbent pads or island dressings
    • A—HUMAN NECESSITIES
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    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
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    • A61F13/02—Adhesive bandages or dressings
    • A61F13/0276—Apparatus or processes for manufacturing adhesive dressings or bandages
    • A61F13/0289—Apparatus or processes for manufacturing adhesive dressings or bandages manufacturing of adhesive dressings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
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    • A61L15/42—Use of materials characterised by their function or physical properties
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Definitions

  • Embodiments described herein include a wound dressing including a perforated impermeable first material layer, an activated carbon layer, and a perforated impermeable second material layer.
  • the activated carbon layer may be an activated carbon cloth such as a woven cloth, non- woven cloth, knitted cloth, activated carbon felt, or combinations thereof.
  • Other embodiments are directed to methods for making a wound dressing including the step of sealing an activated carbon layer between a perforated impermeable first material layer and the perforated impermeable second material layer.
  • Still other embodiments are directed to methods for treating a wound including the steps of contacting a wound dressing comprising an activated carbon layer sealed between a perforated impermeable first material layer and the perforated impermeable second material layer to a wound and applying an adsorbent material over the wound dressing.
  • Some embodiments of methods for treating a wound include contacting a wound dressing comprising an activated carbon layer sealed between a perforated impermeable first material layer and the perforated impermeable second material layer to a wound and administering at least one therapeutic agent to the wound through the wound dressing.
  • FIG. 1 is a schematic illustrating an embodiment of a wound dressing including an activated carbon layer 1 between a first material layer 2 and a second material layer 3 with an adhesive layer for affixing the wound dressing to a wound or tissue surrounding a wound.
  • FIG. 2 is a schematic illustrating a cut-away of an embodiment of a wound dressing including an activated carbon layer 1 between a first material layer 2 and a second material layer 3 with an adhesive layer for affixing the wound dressing to a wound or tissue surrounding a wound.
  • FIG. 3 is a schematic showing the application of an embodiment of the wound dressing of the invention (panel 1) affixing the wound dressing to a wound (panel 2), affixing an absorbent material 5 to the wound over the wound dressing (panel 3), removing the absorbent material 5 and applying a therapeutic agent to the wound through the wound dressing (panel 4), and reaffixing a fresh absorbent material 6 over the wound dressing.
  • substantially no means that the subsequently described event may occur at most about less than 10 % of the time or the subsequently described component may be at most about less than 10 % of the total composition, in some embodiments, and in others, at most about less than 5 %, and in still others at most about less than 1 %.
  • Various embodiments of the invention are directed to a wound dressing including a material that includes activated carbon, methods for preparing such wound dressings, and methods for treating wounds by applying the wound dressing of various embodiments to the wound.
  • the dressings of various embodiments can be used to treat any kind of wound such as, for example, lacerations, cuts, scrapes, abrasions, post-operative wounds, denuded skin, and burns, or other skin problems (e.g., allergies) and dressings of various sizes can be prepared such that minor wounds as well as larger wounds can be treated using the wound dressings of embodiments.
  • the dressing of such embodiments may allow transfer of air and moisture into and out of the wound while immobilizing microbes on the activated carbon.
  • the activated carbon containing material in the wound dressing may provide inherent anti-microbial activity in the absence of other known anti-microbial agents, such as noble metals or pharmaceutical-type antibiotics or improved anti-microbial activity when combined with other anti-microbial agents.
  • the wound dressings described herein can be used to treat wounds on humans or any other animal including, but not limited to, mammals, fish, reptiles, birds, and other creatures.
  • medical and veterinary uses for the wound dressings described herein are encompassed by the invention, and such uses can be carried out by trained medical professionals, physicians, veterinarians, nurses, emergency medical technicians, and the like, or by consumers who purchase the wound dressings described herein over the counter.
  • an activated carbon cloth or a cloth or other flexible material containing activated carbon may be applied to a wound, such as those described above, directly. Therefore, embodiments include activated carbon cloth configured and designed to be applied to a wound. As such, the activated carbon cloth may be shaped to adequately cover a wound. For example, activated carbon cloths designed and configured to be applied directly to a wound may have a square, rectangular, round, butterflied, or other shape, and in other embodiments, that activated carbon cloth or other material containing activated carbon designed and configured to be applied to a wound may include sheets or tapes that can be cut or wrapped around, for example, a portion of a limb, to cover a wound on the limb.
  • the activated carbon cloth or other material containing activated carbon designed and configured to be applied to a wound may include one or more additional components that are provided to, for example, improve healing, reduce adhesion to the wound, improve adherence to skin surrounding the wound, reduce itching, or otherwise aid in improving patient comfort.
  • additional components are described below and can be incorporated into wound dressings consisting of an activated carbon cloth or a cloth or other flexible material including activated carbon.
  • wound dressings including activated carbon cloth or a cloth or other flexible materials that contain activated carbon may include one or more additional material layers.
  • the wound dressing may include a first layer of an activated carbon cloth or a cloth or other flexible material containing activated carbon and a second layer of a flexible material covering the first layer.
  • the second layer may be gauze, an absorbent material, or another medical fabric commonly used in wound dressings, and in some embodiments, the second layer may be a flexible adhesive material that is capable of holding the first layer in position over the wound.
  • the second layer may be provided on the first layer or the second layer may be applied separately.
  • some embodiments include a kit containing an activated carbon cloth or other flexible material and a flexible material configured to cover the activated carbon cloth.
  • the activated carbon cloth or other flexible material containing material may be applied to the wound and the flexible material may be applied over the activated carbon cloth or other flexible material.
  • some embodiments of the invention are directed to a wound dressing including at least three material layers: a first flexible material layer 2, an activated carbon containing layer 1, and a second flexible material layer 3.
  • the first flexible material layer 2 and the second flexible material layer 3 may be composed of any material known in the medical arts that is useful for wound dressings and may generally be composed of a material that allows air and/or fluid to pass through the wound dressing and into the wound. Non-limiting examples of such materials include gauzes and absorbent materials commonly used in wound dressings.
  • the first flexible material layer 2 and the second flexible 3 material layer may be impermeable film, and in some embodiments, at least one of the first flexible material layer 2 and the second flexible material layer 3 may be perforated to allow the air and fluid to pass through the wound dressing and contact the wound.
  • the wound dressings of such embodiments may be applied directly to a wound.
  • at least the first material layer 2 may include an adhesive layer that allows the wound dressing to self adhere to the wound and/or tissue surrounding the wound, and in other embodiments, the wound dressing may be held in place over the wound using a secondary adhesive material such as, for example, tape or other adhesive wound dressings.
  • the activated carbon containing layer 1 may be an activated carbon cloth.
  • the activated carbon cloth of various embodiments may be a woven, non-woven, knitted, or felt activated carbon cloth in various embodiments.
  • the activated carbon containing layer may include activated carbon particles, activated carbon powder, activated carbon fiber, or a combination of these materials.
  • activated carbon particles may be immobilized or attached to a non-activated carbon based cloth and in other embodiments, activated carbon particles, powder, and/or fibers may be contained between sealed layers of a non-activated carbon based cloth.
  • activated carbon particles, powder, and/or fibers may be included in a woven, non- woven, knitted, or felt activated carbon cloth material.
  • the activated carbon containing layer may include borax, i.e., sodium borate, sodium tetraborate, or disodium tetraborate.
  • borax i.e., sodium borate, sodium tetraborate, or disodium tetraborate.
  • the presence of borax in the activated carbon containing layer may enhance the antimicrobial activity of the activated carbon in the absence of a known anti-microbial agent.
  • Any amount of borax may be included in the activated carbon containing layer.
  • the borax may be about 0.001 wt. % to 50 wt. %, and in other embodiments, the borax may be about 0.01 wt. % to 30 wt. % or about 0.1 wt. % to 25 wt. %.
  • the activated carbon cloth may further include one or more anti-microbial agents other than activated carbon.
  • the activated carbon containing layer may include a noble metal such as silver, gold, palladium, platinum, copper, zinc, or a combination thereof, and in particular embodiments, the noble metal may be silver or zinc. In such embodiments, the noble metal may be provided at about 0.001 wt. % to about 30 wt. % or about 0.01 wt. % to about 10 wt. %.
  • the noble metal may be provided as noble metal particles or powder, and in such embodiments, the particle size of the noble metal particles may be less than about 100 nm, less than 50 nm, and less than 25 nm.
  • noble metal particles or powder are associated with the activated carbon in the activated carbon containing layer, any means known in the art can be used to create such an association including, but not limited to, thermocracking, electroplating, electroless plating, or vacuum plating.
  • noble metal particles or powder may be associated with activated carbon cloth by immersion.
  • activated carbon fibers or cloth may be immersed in a solution of silver nitrate for 1 to 720 minutes at a pH of 3 to 8, which reduces the silver allowing the silver to form particles on the surface of the activated carbon fiber or cloth.
  • Such methods may further include drying the fiber or cloth to remove residual water, which is typically carried out at a temperature of from about 25° C to about 150° C.
  • Silver-carrying activated carbon fiber prepared according to the above process generally results in activated carbon fibers having a BET surface area of greater than about 400 m/g, carbon content of greater than about 50 wt %, silver content of greater than about 0.001 wt %, and a density of greater than about 1.8 g/m .
  • a therapeutically active agent can be included in the activated carbon containing layer.
  • the therapeutically active agent provided may be pre- adsorbed into the pore volume of the material and its subsequent release from the material may be controlled.
  • the release of the therapeutically active agent may be controlled by applying an electrical current to the material.
  • suitable therapeutically active agents may include antibiotics, antimicrobials, sulfonamides, antiseptics, analgesics, or anesthetics and other medicaments and substances used to promote healing such as osmotic colloids, protease inhibitors, proteolytic enzymes, growth factors, steroidal or non-steroidal antiinflammatory drugs, nutrients, antioxidants, and the like, and any combination of therapeutically active agents.
  • Examples of particular active agents that may be useful in embodiments may include, but are not limited to, acrisorcin, haloprogin, iodochlorhydroxyquin, tolnaftate, triacetin, centella asiatica, econazole nitrate, mafenide, mupirocin, povidone iodine, chlohexidine, silver sulfadiazine, povidone iodine, silver salts, triclosan, sucralfate, quaternary ammonium salts, tetracycline, penicillins, terramycins, erythromycin, bacitracin, neomycin, polymycin B, mupirocin, clindamycin, and any mixtures thereof.
  • the activated carbon layer may further include one or more non-toxic, pharmaceutically, and dermato logically acceptable carriers, diluents, or excipients or combinations thereof.
  • the therapeutically active agent and/or carriers, diluents, and/or excipients may be prepared for topical use and can be in various dosage forms including, but not limited to, a gel, a paste, an ointment, a cream, an emulsion, or a suspension.
  • a suitable thickener such as, aluminum stearate or hydrogenated lanolin, or gelling agent can be added to an aqueous or oil base to formulate an ointment or cream.
  • excipients examples include starch, tragacanth, cellulose derivative, polyethylene glycol, silicones, bentonite, silicic acid, talc, or a mixture thereof.
  • the activated carbon can be mixed with the therapeutically active agent, carrier, diluent, and/or excipient and other active components to provide the desired dosage form.
  • the first material layer 2 and the second material layer 3 may be composed of the same material or different materials and may be composed of any material known and used in the medical arts including synthetic and natural materials used in, for example, commercially available bandages and gauzes.
  • the first material layer 2 and the second material layer 3 may be composed of polymeric materials.
  • the embodiments described herein are not limited to any particular polymeric material.
  • the first material layer 2 and the second material layer 3 may be composed on an impermeable material, and in other embodiments, the impermeable material may be a polymer.
  • Such polymers may generally be conformable but not substantially elastomeric, and in some embodiments, the polymer may be hydrophilic.
  • suitable polymers include, but are not limited to, polyethylene, polypropylene, polyester, polyamides such as nylons, fluoropolymers such as polyvinylidene fluoride (PVDF) or polytetrafluoroethylene (PTFE), ethylene methyl acrylate (EMA), and mixtures thereof.
  • PVDF polyvinylidene fluoride
  • PTFE polytetrafluoroethylene
  • EMA ethylene methyl acrylate
  • the polymers may be drug-impermeable.
  • Such drug impermeable materials include, for example, polyvinyl chloride, polyvinyl dichloride, polyurea, polyolefins, such, but not limited to, ethylene vinylacetate copolymer, polyethylene, and polypropylene, and polyesters, such as, but not limited to, polyethylene terephthlate, and the like and combinations and mixtures of these.
  • the polymers of various embodiments can be provided as a single polymer layer or film or a laminate having multiple polymer layers.
  • the polymer layers can be as thin as possible consistent with the need for physical integrity during manufacture and use.
  • the first material layer 2 and the second material layer 3 may each have a basis weight of from about 1 g/m 2 to about 500 g/m 2 and in other embodiments, the first material layer 2 and the second material layer 3 may each have a basis weight of from about 10 g/m to about 200 g/m .
  • the thickness and basis weight of the first material layer 2 and the second material layer 3 may be the same or different.
  • the first material layer 2 and the second material layer 3 may each have a basis weight that is the same, and in other embodiments, the second material layer 3 may have a basis weight that is greater than the basis weight of the first material layer 2.
  • the thicker second material layer 3 may provide abrasion resistance to the outer surface of the dressing, while the thinner first material layer 2 may provide improved flexibility for the surface of the dressing contacting the wound.
  • the polymeric films used in the first material layer 2 and the second material layer 3 may be perforated.
  • the polymer film used in the first material layer 2 and the second material layer 3 may have from about 5 perforations/cm 2 to about 50 perforations/cm 2 and in other embodiments, the polymer films may have from about 10 perforations/cm 2 to about 30 perforations/cm 2. The perforations of such
  • embodiments may have an area of from about 0.01 mm to about 2.0 mm and a hole-to-land ratio, defined as the ratio of the total area of the perforations to the total area of the film less the area of the perforations both areas being viewed in plans projection, of from about 0.01 to about 1.0, about 0.05 to about 0.5 or in some embodiments, from about 0.1 to about 0.3.
  • Particular embodiments include a wound dressing including at least three components: (1) a double sided adhesive film which may include a release paper on at least one side to unwind the reel, (2) an activated carbon cloth such as Zorflex activated carbon cloth or a cloth or other flexible material containing activated carbon, and (3) a single sided adhesive film which may or may not have a release paper on the adhesive side.
  • these components may be provided on reels, and manufacture of the wound dressing can be carried out by combining or contacting the leading edges of the components and laminating the components in a laminator to create the wound dressing.
  • the exposed adhesive side of double sided adhesive film may contact one side of the activated carbon cloth leaving the release paper on the other side of the double side's adhesive film as an outer exposed side of the wound dressing.
  • the adhesive side of the single sided adhesive film may contact activated carbon cloth at the side opposite the double sided adhesive such that the non-adhesive side is exposed.
  • Lamination may result in full width rolls of wound dressing, and in some embodiments, the laminated wound dressing may be cut into usable sized portions. The retained layer of release paper can be removed immediately before use by the user.
  • Additional methods for preparing the wound dressings of embodiments include preparing perforated polymer materials as discussed above. For example, in mesh perforation, a film of the polymeric material is supported on a reticulated mesh surface and heated to its softening temperature. Suction is applied through the mesh, or air is blown onto the film above the mesh resulting in an impression of the mesh onto the film and the formation of perforations in the film at the interstices of the mesh.
  • Mesh perforation technique are described in more detail in U.S. Patent No. 3,054,148, the entire content of which is expressly incorporated herein by reference.
  • the first material layer 2 and the second material layer 3 may be textured.
  • the term "textured" indicates that the film is patterned in relief with, for example, protruding ridges or nubs. Such ridges or nubs are generally rounded and may project from about 0.1 mm to about 1.5 mm above the median plane of the film surface or in some embodiments from about 0.2 mm to about 1.0 mm above the median plane of the film.
  • either the first material layer 2 or the second material layer 3 material layer, or both the first material layer 2 and the second material layer 3 may be textured.
  • the first material layer 2 may be textured, which may render the first material layer 2 less adherent to a wound bed.
  • the second material layer 3 may have a smoothed perforated surface and may be designed to be the rear side (i.e., applied facing away from the wound surface) of the envelope that is smoother than the first material layer 2 designed to be the front (i.e., wound contacting) side of the envelope.
  • the surface roughness or degree of texturization of the rear side of the second material layer 3 may be less than about 80% of the surface roughness or degree of texturization of the front side of the first material layer 2.
  • the degree of texturization of the rear may be less than about 70%, less than about 50%, or less than about 30%>.
  • the textured wound contacting surface of the envelope may allow for low adherence and good wicking of liquid from the wound into the activated carbon layer 1 through the first material layer 2.
  • the smoother second material layer 3 on the rear side of the envelope may provide excellent adhesion to the adhesive layer on the backing sheet, while retaining perforations that enable water vapor to diffuse out through the second material layer 3 preventing saturation of the activated carbon layer 1.
  • smoothed is meant that the rear second material layer 3 has less surface texturing (roughness, unevenness) than the front first material layer 2 of the envelope.
  • substantially no projections on the smoothed surface will project greater than 100 ⁇ above the median plane of the smoothed film surface, and in other embodiments, substantially no projections will project greater than 25 ⁇ above the median plane of the smoothed film surface.
  • the first material layer 2 and the second material layer 3 may form an envelope or island for the activated carbon layer 1.
  • envelope or “island” as used herein means that the front and back faces of the activated carbon layer 1 are substantially covered by the first material layer 2 and the second material layer 3, such that both faces and each edge of the activated carbon layer 1 are covered by the first material layer 2 and the second material layer 3.
  • two sheets of a polymeric film may be positioned such that a first sheet is above the activated carbon layer 1 and a second sheet is below the activated carbon layer 1 covering the top and bottom faces of the activated carbon layer 1 and extending beyond the edges of the activated carbon layer 1.
  • an envelope can be formed from a single polymer film that has been folded with the activated carbon layer 1 between the folds.
  • the opposed longitudinal edges of the film may overlap, and the overlapping edges can be bonded together to form the envelope.
  • Such envelopes or islands can be sealed and the polymeric film edges can be bonded using, for example, hot melt adhesives or heat bonding, and can be made by minor modification of conventional form-fill-seal equipment.
  • the second material layer 3 may be prepared from a material that is semi-permeable.
  • the second material layer 3 is permeable to water vapor but not permeable to liquid water, and/or the second material layer 3 may be microorganism-impermeable.
  • Suitable materials for the second material layer 3 may have a moisture vapor transmission rate (MVTR) of, for example, about 300 g/m /24 hrs. to about 5000 g/m 2 /24 hrs., or from about 500 g/m 2 /24 hrs. to about 2000 g/m.sup.2 /24 hrs. at about 37° C at 100% to 10% relative humidity.
  • the second material layer 3 of such embodiments may further have a thickness of from about 10 ⁇ to about 1000 ⁇ or from about 100 ⁇ to about 500 ⁇ .
  • the MVTR of the dressing of various embodiments as a whole may be lower than that of second material layer 3 alone, because the polymeric film envelope partially obstructs moisture transfer through the dressing.
  • the MVTR of the dressing (measured across the island portion of the dressing which includes the activated carbon layer 1) may be from about 20% to about 80% of the MVTR of the second material layer 3 alone.
  • the MVTR of the dressing may be from about 20% to about 60% or about 40% of the MVTR of the second material layer 3 alone.
  • moisture vapor transmission rates may allow the wound under the dressing to heal under moist conditions without causing the skin surrounding the wound to macerate.
  • Various embodiments of the dressing may include an adhesive layer 4 on either the first material layer 2 or the second material layer 3 or both the first material layer 2 and the second material layer 3.
  • an adhesive layer 4 may be provided on the first material layer to allow the first material layer to adhere to the wound and/or tissue surrounding the wound.
  • the adhesive layer 4 can be moisture vapor transmitting and/or patterned to allow passage of water vapor through the adhesive layer 4.
  • the adhesive layer 4 may be moisture vapor transmitting and pressure-sensitive, meaning that it forms a bond when applied with light pressure, of the type conventionally used for island-type wound dressings.
  • Adhesives useful in various embodiments include, but are not limited to, acrylate ester copolymers, polyvinyl ethyl ether and polyurethane pressure sensitive adhesives.
  • the relative thickness of the adhesive layer may vary among embodiments and may be optimized based on the type of adhesive used.
  • the basis weight of the adhesive layer may be from about 20 g/m to about 250 g/m 2 or from about 50 g/m 2 to 150 g/m 2.
  • the adhesive may be a polyurethane -based pressure sensitive adhesive.
  • the adhesive layer 4 may be continuous with the first material layer 2 and/or the second material layer 3, and in other embodiments, the adhesive layer may extend outwardly from the island created by the activated carbon layer 1 and the envelope to form an adhesive-coated margin as in conventional island-type wound dressings.
  • the adhesive layer 4 may further include a release coat or a cover layer to protect the adhesive and absorbent layer before use.
  • Various release coats and cover layers are known in the art and can be used in conjunction with embodiments of the invention.
  • the cover layer may be a silicone release-coated paper.
  • the wound dressings of various embodiments described above will be sterile and can be packaged in a microorganism-impermeable container such as a pouch.
  • Embodiments further include methods for using the wound dressings described above.
  • the methods of various embodiments generally include the step of contacting a wound with a wound dressing 10 having a first material layer 2 and the second material layer 3 and an activated carbon layer 1 directly to a wound such that the first material layer 2 contacts and adheres to the wound, and an exemplary method is illustrated in FIG. 3.
  • the wound dressing 10 may include an adhesive layer 4 that allows the dressing to remain in place over the wound after contacting the wound, and in other embodiments, the method may include applying adhesive tape or another form of bandage over the wound dressing 10 to allow it to remain in position over the wound.
  • the method may further include contacting the wound dressing 10 with an absorbent material 5, such as cotton or gauze, that may absorb and collect fluids from the flow through the wound dressing 10.
  • an absorbent material 5 such as cotton or gauze
  • the absorbent material 5 may adhere to the wound dressing by an adhesive layer associated with the second material layer 3, or the absorbent material may remain in place over the wound by applying adhesive tape or another form of bandage over the absorbent material 5.
  • Some embodiments may include the step of removing the absorbent material 5 without disturbing the wound dressing 10.
  • the absorbent material 5 may be changed without exposing the wound to the environment, because the wound dressing 10 may remain in place while used absorbent material is removed and fresh unused absorbent material is applied to the wound.
  • a topical composition including one or more therapeutic agents may be applied to the outer surface of the wound dressing while the position of the wound dressing over the wound is maintained.
  • the therapeutic agents may be carried directly to the wound through the dressing without removing the dressing and exposing the wound to the environment.
  • Embodiments are not limited to specific therapeutic agents, and the material used to prepare the first material layer 2 and the second material layer 3 may be selected to provide an effective flow of therapeutics through the wound dressing.
  • any type of topical composition including, but not limited to, gels, pastes, ointments, creams, emulsions, suspensions, or the like containing the therapeutic agent may be applied.
  • the wound dressing and methods can be used to treat any type of wound, including lacerations, cuts, scrapes, abrasion, post-operative wounds, denuded skin, burns, and the like.
  • the wound dressing can remain in contact with the wound throughout the healing process because therapeutic agents can be administered topically through the wound dressing of the invention and absorbent "bandages" can be changed without removing the wound dressing of the invention.
  • This provides a means for reducing exposure of the wound to the environment while allowing free flow of air, fluids, nutrients, and therapeutics into and out of the wound.
  • the anti-microbial activity of the activated carbon layer also reduces the likelihood of infection by trapping and eradicating microbes in the wound at the time the wound dressing is applied and throughout the healing process by immobilizing microbes before they can reach the wound itself.

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JP2014527324A JP2014525291A (ja) 2011-08-24 2012-08-24 活性炭を含む創傷被覆材
CA2845892A CA2845892A1 (en) 2011-08-24 2012-08-24 Activated carbon containing wound dressing
EP12825640.1A EP2747723A4 (en) 2011-08-24 2012-08-24 WOUND DRESSING CONTAINING ACTIVE COAL
KR1020147007582A KR20140054331A (ko) 2011-08-24 2012-08-24 활성탄을 함유하는 상처 드레싱
RU2014110970/12A RU2014110970A (ru) 2011-08-24 2012-08-24 Раневая повязка, содержащая активированный уголь
BR112014004287A BR112014004287A2 (pt) 2011-08-24 2012-08-24 curativo para ferimento, método para preparar um curativo para ferimento e método para tratar um ferimento
CN201280052413.3A CN103889379A (zh) 2011-08-24 2012-08-24 含有活性炭的伤口辅料

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RU2014110970A (ru) 2015-09-27
WO2013028966A3 (en) 2013-04-18
CN107115551A (zh) 2017-09-01
CN103889379A (zh) 2014-06-25
EP2747723A4 (en) 2015-05-20
JP2014525291A (ja) 2014-09-29
EP2747723A2 (en) 2014-07-02
CA2845892A1 (en) 2013-02-28
KR20140054331A (ko) 2014-05-08
US20170100504A1 (en) 2017-04-13
US20130053807A1 (en) 2013-02-28
BR112014004287A2 (pt) 2017-03-28

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