WO2013002324A1 - Système de gestion de température - Google Patents

Système de gestion de température Download PDF

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Publication number
WO2013002324A1
WO2013002324A1 PCT/JP2012/066527 JP2012066527W WO2013002324A1 WO 2013002324 A1 WO2013002324 A1 WO 2013002324A1 JP 2012066527 W JP2012066527 W JP 2012066527W WO 2013002324 A1 WO2013002324 A1 WO 2013002324A1
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WIPO (PCT)
Prior art keywords
heat storage
temperature
container
heat
storage material
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PCT/JP2012/066527
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English (en)
Japanese (ja)
Inventor
藤井健介
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株式会社スギヤマゲン
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Publication of WO2013002324A1 publication Critical patent/WO2013002324A1/fr

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J3/00Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B65CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65DCONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/38Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation
    • B65D81/3825Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents with thermal insulation rigid container being in the form of a box, tray or like container with one or more containers located inside the external container

Definitions

  • the present invention relates to a temperature management system. More specifically, a temperature management system that stores investigational drugs and other drugs, blood, body fluids, urine, human organs, and other desired objects and manages them at a desired temperature, and temperature management using the temperature management system Regarding the method.
  • the temperature management system of the present invention is mainly used for transfer, delivery and transportation, but is also used for storage.
  • Each of the temperature management methods shown in FIGS. 6A to 6D discloses a method for managing the temperature by storing the heat storage material 10 (cold storage material) in the heat insulating container 1 such as a heat insulating container or a heat insulating container.
  • the heat storage material 10 is composed of a heat storage agent (cold storage agent) having a melting point of 0 ° C. This cold storage material is used after being cooled to -15 ° C to -25 ° C.
  • a heat storage material 10 (hereinafter also referred to as “cold storage material 10”) is stored on the rear side in the container 1.
  • the second method is to store the regenerator material 10 on the front side and the rear side in the container 1.
  • the third method is to store the regenerator material 10 on the front and rear side and the both sides in the container 1.
  • the fourth method as shown in FIG. 6D, the cold storage material 10 is accommodated by increasing the number of sheets on the front and rear side and both side portions in the container 1 as compared with the third method.
  • the first to fourth methods have the following problems.
  • (1) Problem of variation in internal temperature The first method has a problem that the internal temperature varies in proportion to the difference in distance (distance) between each position of the container 1 and the regenerator material 10. That is, the internal temperature increases in proportion to the difference in distance from the cool storage material 10. The temperature difference becomes larger as the insulation performance of the container 1 is lower.
  • (2) Problem of excessive cooling at the beginning of transportation The second method and the third method have a problem of excessive cooling at the beginning of transportation. That is, if the regenerator material cooled to minus 15 ° C. to 25 ° C. is used as it is, there is a problem of excessively cooling the inside of the container 1 and therefore the contents (such as investigational drug) in the container 1 in the initial stage. is doing.
  • the temperature management method has the above-described problems.
  • no temperature management system that can solve the above problem has been proposed yet.
  • the present invention has been made in view of the above circumstances, and provides a temperature management system that solves the above-described problems and can stably and satisfactorily manage various desired objects at a predetermined temperature. It is the purpose.
  • a temperature management system is a temperature management system that stores various desired objects and maintains the stored objects at a predetermined temperature, and has a heat insulating structure having an opening.
  • a heat insulating container provided with a container body, a heat insulating opening / closing lid for opening and closing the opening of the container body, a heat conductive container body for storing the object, and a heat conductive material
  • a heat conductive inner container that is detachably accommodated in the container body, one or more first lower-side heat storage materials, and one or more second lower-side parts.
  • the second lower-side heat storage material and the second upper-side heat storage are configured with a first heat storage agent having substantially the same melting point. Is composed of a second heat storage agent having substantially the same melting point, and the second heat storage agent is composed of a heat storage agent having a melting point lower than the melting point temperature of the first heat storage agent, and the first lower side heat storage agent
  • the material and the second lower-side heat storage material are superposed so as to be in surface contact with each other, and the second lower-side heat storage material is disposed in the container so as to be in surface contact with the bottom side of the container.
  • the inner container is placed in the container so as to be in surface contact with the first lower-side heat storage material disposed in the container, and the first upper-side heat storage material and the second upper-side material are placed in the container.
  • the heat storage material is a temperature management system configured to superimpose so as to be in surface contact with each other and to be disposed on the inner container so that the first upper heat storage material is in surface contact with the upper surface of the inner container. .
  • heat insulating container is used as a concept including a heat insulating container, a heat insulating container, a heat insulating storage box, a heat insulating container, or a heat insulating bag.
  • first lower side heat storage material and “second lower side heat storage material” and “first upper side heat storage material” and “second upper side heat storage material”
  • second upper side heat storage material The terminology is used for convenience to facilitate understanding of the explanation. That is, in the present invention, the “first lower-side heat storage material” and the “first upper-side heat storage material” are composed of the same or substantially the same heat storage agent (first heat storage agent). Therefore, both can be used in common for the lower side and upper side parts without distinction.
  • the same or substantially the same heat storage agent as in the case of the first heat storage agent. It can be used in common for the upper and lower sides without distinction.
  • the cold heat from the second lower-side heat storage material and the second upper-side heat storage material configured from the second heat storage agent are each configured from the first heat storage agent. Absorbed by the first lower heat storage material and the first upper heat storage material, and the solidification heat at the freezing point of the first heat storage agent is from the first lower heat storage material and the first upper heat storage material. Heat conduction into the inner container. In this way, the cold heat of the second heat storage agent is not directly conducted to the inner container, but the first heat storage agent absorbs once and the heat of solidification of the first heat storage agent is conducted to the inner container. It is. Therefore, it is possible to efficiently conduct heat of solidification at a predetermined temperature from the first heat storage agent into the inner container.
  • the first heat storage agent absorbs the cold heat of the second heat storage agent and conducts the solidification heat of the first heat storage agent into the inner container. Cooling to a temperature below a predetermined lower limit can be prevented. Moreover, the temperature of each position in the container can be maintained uniformly.
  • the first heat storage agent stores heat of a desired value higher than the freezing point of the first heat storage agent
  • the second heat storage agent stores heat of a desired value lower than the freezing point of the second heat storage agent. It is preferable to use them.
  • the second heat storage agent is preferably composed of a heat storage agent having a melting point that is 3 ° C. to 10 ° C. lower than the melting point temperature of the first heat storage agent.
  • the temperature management method according to the present invention is a temperature management method for maintaining and managing a desired container at a predetermined temperature using the temperature management system according to the present invention.
  • the following operational effects can be obtained. (1) It is possible to stably and satisfactorily manage the temperature by maintaining the investigational drug, specimen, and other various stored items at a predetermined set temperature. (2) The temperature maintenance time by the heat storage agent can be lengthened. (3) The problem of variation in the internal temperature can be solved and the temperature can be maintained at a substantially uniform temperature. (4) Overcooling in the initial stage can be prevented. (5) The problem of deviation of the lower limit temperature due to negative outside air temperature can be solved. (6) The problem of deviation of the upper and lower limit temperatures due to fluctuations in the outside air temperature can be solved. (7) Operation efficiency can be improved. (8) Equipment cost can be reduced.
  • FIG. 1A It is a perspective view which shows roughly the structure of an example of the container in the temperature management system of one Embodiment of this invention. It is a perspective view which shows roughly the structure of an example of the inner container in the temperature management system of one Embodiment of this invention. It is a perspective view which shows roughly the positional relationship of the 1st and 2nd lower side thermal storage material in the temperature management system of one Embodiment of this invention, and the 1st and 2nd upper side thermal storage material. It is a center longitudinal cross-sectional view of the state which closed the container shown in FIG. 1A. It is a cross-sectional view of the container main body of the container shown in FIG. 1A.
  • FIG. It is the longitudinal cross-sectional view which showed the temperature management system roughly in order to demonstrate the effect
  • the temperature management system of the present embodiment includes a heat insulating container 2, a heat conductive inner container 3, a desired number of first lower-side heat storage materials 4a, and a desired number of second lower portions.
  • a side heat storage material 5a, a desired number of first upper side heat storage materials 4b, and a desired number of second upper side heat storage materials 5b are provided.
  • the heat storage material is sometimes called a cold storage material.
  • the container 2 can be configured in an arbitrary structure and type, but it is preferable to employ a material or a structure having high heat insulation performance.
  • the container 2 of the present embodiment is a container formed in a substantially rectangular parallelepiped shape having heat insulation properties.
  • the container 2 includes a heat-insulating container body 20 having an opening 21 having an upper end opened, and a heat-insulating opening / closing lid 22 that opens and closes the opening 21 of the container body 20.
  • the container body 2 includes a front wall 23a and a rear wall 23b opposed to the front and rear, side walls 23c and 23d opposed to the left and right, and a bottom wall 23e (see FIG. 2A), and is formed to have a substantially rectangular cross section.
  • a planar fastener 24a is fixedly attached to the outer wall surfaces near the upper ends of the front wall 23a and the side walls 23c, 23d.
  • the open / close lid portion 22 includes flaps 25a, 25b, and 25c extending from the left and right edges and the front edge.
  • a planar fastener 24b that is detachably engaged with the fastener 24a is fixedly attached to the inner surface of each flap 25a, 25b, 25c.
  • the container 2 of the present embodiment has the above-described configuration, and the opening 21 is closed by the opening / closing lid part 22, and each flap of the lid part 22 is pressed against the front wall and both side walls of the container body 20 to be planar.
  • the fasteners 24a and 24b are configured to be detachably attached.
  • the thing of arbitrary structures other than illustration can also be employ
  • the container 2 is formed in a desired size.
  • the outer dimension Y 1 is about 380 cm and the inner dimension Y 2 is 300 cm when the lid is closed.
  • the main body 20 has a lateral width (lateral width) outer dimension X 1 : about 500 cm, an inner dimension X 2 : about 420 cm, a front and rear width outer dimension X 3 : about 445 cm, and an inner dimension X 4. : It is formed in about 365 cm.
  • size of the container 2 can be changed arbitrarily.
  • the inner container 3 includes a container body 30 having an opening 31 having a thermal conductivity and an upper end opened, and an opening / closing lid 32 having a thermal conductivity and opening and closing the opening 31.
  • a material having high heat conductivity is selected and adopted. Examples of the material having high thermal conductivity include aluminum, an aluminum alloy, and copper. In this embodiment, an aluminum inner container is employed. However, it is not limited to the materials exemplified above.
  • the inner container 3 accommodates a desired desired accommodation 6 (see FIG. 3) and accommodates it in and out of the container 2. Accordingly, the size of the inner container 3 is set corresponding to the size of the inside (the storage chamber) of the storage device 2. Further, in the container 2, a desired number of first and second lower-side heat storage materials 4 a and 5 a below the inner container 3, and a desired number of first and second upper sides on the inner container 3. The heat storage materials 4b and 5b are arranged and accommodated. Therefore, the size of the inner container 3 is a size that can be accommodated in the container 2 in consideration of an appropriate accommodation space formed for accommodating a desired number of lower-side heat storage materials and upper-side heat storage materials. Formed.
  • the first and second lower-side heat storage materials 4a and 5a and the first and second upper-side heat storage materials 4b and 5b each have a melting point corresponding to a predetermined temperature range in which the heat storage agents are housed and temperature-controlled. Select and use a thermal storage agent.
  • the first heat storage agent conducts heat of solidification to the inner container.
  • the 2nd heat storage agent makes the 1st heat storage agent absorb the cold heat.
  • the first heat storage agent constituting the first lower heat storage material 4a and the first upper heat storage material 4b is a melting point temperature within a predetermined temperature range for temperature control, for example, near the lower limit to the middle of the temperature range.
  • a heat storage agent having a melting point temperature of about part can be employed.
  • the second heat storage agent constituting the second lower heat storage material 5a and the second upper heat storage material 5b has a melting point temperature below the lower limit of the temperature zone, for example, a temperature lower by about 3 ° C. to 10 ° C. than the lower temperature limit. It is possible to employ a heat storage agent having a melting point temperature of.
  • a case where temperature control is performed in a temperature range of 2 ° C. to 8 ° C. will be specifically described.
  • a heat storage agent having a melting point of 3 ° C. to 5 ° C. can be employed.
  • a heat storage agent having a melting point of 0 ° C. (generally referred to as a cold storage agent) can be employed.
  • a heat storage material having a melting point of 4 ° C. (freezing point of 3.5 ° C.) is employed as the first heat storage agent constituting the first lower-side heat storage material 4a and the first upper-side heat storage material 4b.
  • fusing point 0 degreeC (brand name: Evacool 1000W / 500N, Registered trademark).
  • This second heat storage agent is generally called a cold storage agent.
  • first heat storage materials composed of 2000 g of the first heat storage agent
  • second heat storage materials composed of 1000 g of the second heat storage agent per sheet
  • the temperature management system of the present embodiment is implemented by the following procedure, for example.
  • the second heat storage materials 5a and 5b are stored in a freezer at ⁇ 15 ° C. or lower for 10 hours or more and cooled to about ⁇ 20 ° C.
  • the first heat storage materials 4a and 4b are stored in a refrigerator at 4 ° C. or higher (for example, about 6.5 ° C.) for 3 hours or longer and cooled (heat storage) to about 6.5 ° C. (temperature above the freezing point).
  • the lid portion 22 of the container 2 is opened, and the second lower heat storage material 5 a (the same as the second upper heat storage material 5 b) taken out from the freezer is attached to the main body 20. It is placed on the bottom side of the.
  • two second lower heat storage materials 5a, 5a are arranged side by side.
  • the first lower heat storage material 4a taken out of the refrigerator (the same as the first upper heat storage material 4b) is polymerized so as to be in surface contact with the second lower heat storage materials 5a and 5a. Arrange.
  • the inner container 3 storing the target storage 6 is placed in the storage so as to be in surface contact with the first lower heat storage material 4a.
  • the first upper heat storage material 4b taken out from the refrigerator is disposed in the container so as to be in surface contact with the inner container 3.
  • the container 2 is closed by the opening / closing lid portion 22. To do.
  • the cold heat from the second heat storage materials 5a and 5b arranged above and below (initially about ⁇ 20 ° C. but becomes about 0 to 2 ° C. after about 2 to 3 hours)
  • the heat storage materials 4a and 4b are absorbed by the melted first heat storage agent, whereby the first heat storage agent is solidified.
  • the heat of solidification about 3.5 ° C. to about 4 ° C.
  • the freezing point 3.5 ° C.
  • FIG. 5 schematically shows a temperature management system according to another embodiment (embodiment 2) of the present invention.
  • the first lower-side heat storage material 4a and the first upper-side heat storage material 4b are superposed so as to come into surface contact with each other (two in total) in the container body 20. It is arranged and configured. Other configurations are the same as those of the first embodiment.
  • the cold heat from the upper and lower second heat storage materials 5a, 5b is the first of the first heat storage materials 4a, 4b disposed in surface contact with the respective second heat storage materials.
  • the heat of solidification of each of the heat storage agents 4a, 4b absorbed by the heat storage agent and in surface contact with the inner container 3 is conducted into the inner container 3 to cool the contents 6 in the inner container 3 at the above temperature.
  • the temperature of the container 6 is controlled so as to be maintained at a predetermined temperature.
  • the second embodiment it is possible to improve the effect of preventing the upper and lower limit temperatures from deviating due to fluctuations in the outside air temperature.
  • the first embodiment also exhibits the effect of preventing the deviation of the upper and lower limit temperatures due to fluctuations in the outside air temperature.
  • the present invention is not limited to the desired temperature range such as 10 ° C. to 15 ° C. or 15 ° C. to 25 ° C. It can be applied to a temperature management system that maintains the temperature of.
  • the first and second heat storage agents corresponding to each temperature range are selected and adopted, and the temperature control can be performed by performing the same procedure as described above. it can.
  • each number of the 1st and 2nd heat storage material comprised from a 1st and 2nd heat storage agent can be increased / decreased as desired.
  • the upper side and lower side heat storage materials are used on condition that at least one of each of the first and second heat storage materials is used in combination.
  • test example Next, an example of a test example will be described.
  • the temperature was controlled so as to be maintained within the range of 2 ° C. to 8 ° C., and the test example was performed substantially according to the method described in the first embodiment.
  • This test example is a temperature measurement test.
  • the first and second heat storage materials are simply expressed in terms of the first heat storage material and the second heat storage material without distinguishing between the lower side and the upper side.
  • Container used heat-insulating container of Embodiment 1
  • First heat storage material Two heat storage materials composed of 2000 g of heat storage agent having a melting point of 4 ° C. (freezing point 3.5 ° C.) are used (one on top and one below) use) Input conditions Place in a 16.5 ° C refrigerator for 3 hours, cool to 6.5 ° C (heat storage), take out from the refrigerator, and then put directly into the container.
  • Second heat storage material melting point 0 ° C (freezing point 0 ° C) 4 pieces of heat storage material composed of 1000g of heat storage agent (use 2 pieces each on the top and bottom)
  • Input conditions Place in a -20 ° C freezer for 10 hours, cool to -20 ° C, take out from the freezer, and then put directly into the container.
  • Inner container Uses an aluminum inner container
  • part in the inner container accommodated in the container on the said conditions was measured.
  • the temperature measurement was carried out for 48 hours for each of the middle central part P 1 , the lower middle part P 2 , the middle side part P 3 , and the lower side part P 4 in the inner container (see FIG. 4).
  • the measurement results are shown in Table 1 below.
  • “R” in the top column represents the temperature around the container in the test chamber, and the numerical value in the “R” column represents the temperature around the container (unit: ° C.).
  • T” in the bottom column is the elapsed time, and the unit of the numerical value in the column is time.
  • the numerical values in each column of P 1 to P 4 indicate temperature (unit: ° C.).
  • each part of P 1 to P 4 in the inner container at the start of the test is about 18 ° C., that is, the temperature of each part at the start exceeds the upper limit temperature (8 ° C.).
  • the temperature rapidly decreases during the elapsed time from the start of 0.4 hour to 0.5 hour. That is, after 0.4 hours from the start of the test, each part P 1 ... P 4 is cooled to a temperature of about 10 ° C., and after 0.5 hours, it is cooled to a temperature within the upper limit (8 ° C.).
  • each part is about 6 ° C after 1 hour from the start, and becomes 5 ° C or less after 2 hours.
  • the temperature of each part gradually decreases in proportion to the time from 2 hours to about 35 hours and reaches about 3.5 ° C. to about 3.7 ° C., and gradually thereafter. It rises to about 4.0 to about 4.5 ° C. after 48 hours.
  • the temperature is cooled to the upper limit after 0.5 hours from the start of the test, and reaches about 6 ° C. after 1 hour.
  • the temperature is maintained at about 4.8 to about 3.5 ° C. for 2 to 48 hours.
  • each part should be stably maintained at a temperature within the predetermined temperature range (2 ° C to 8 ° C) without departing from the upper and lower temperature limits. There was found. It was also demonstrated that each of the portions P 1 to P 4 can be maintained at a substantially uniform temperature.
  • the objects are managed to be stored and maintained at a desired temperature. It is useful as a temperature management system.
  • Container body 21 Opening part, 22 Opening / closing lid part 23a Front wall, 23b Rear wall 23c, 23d Side wall, 23e Bottom wall 24a, 24b Planar fasteners 25a, 25b, 25c Flap 3 Thermal conductivity content Container 30
  • Inner container main body 31 Opening portion, 32 Opening / closing lid portion 4a First lower-side heat storage material 4b First upper-side heat storage material 5a Second lower-side heat storage material 5b Second upper-side heat storage material 6

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  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Packging For Living Organisms, Food Or Medicinal Products That Are Sensitive To Environmental Conditiond (AREA)

Abstract

Le système de gestion de température de l'invention est équipé : d'un réceptacle de stockage (2) doté de propriétés d'isolation thermique; d'un contenant interne (3) doté de propriétés de conduction thermique qui admet un nouveau médicament de recherche ou diverses autres substances de manière à permettre le retrait / l'introduction dans le réceptacle de stockage; d'un ou plusieurs premiers matériaux d'accumulation thermique côté partie inférieure et supérieure (4a, 4b); et d'un ou plusieurs seconds matériaux d'accumulation thermique côté partie inférieure et supérieure (5a, 5b). Les faces des premier et second matériaux d'accumulation thermique côté partie inférieure (4a, 5a) sont mises en contact, le second matériau d'accumulation thermique côté partie inférieure (5a) est disposé côté partie fond du réceptacle de stockage, et le contenant interne est posé sur le premier matériau d'accumulation thermique côté partie inférieure (4a) à l'intérieur du réceptacle de stockage. Les faces des premier et second matériaux d'accumulation thermique côté partie supérieure (4b, 5b) sont mises en contact, le premier matériau d'accumulation thermique côté partie supérieure (4b) est disposé de sorte à être en contact sur le contenant interne. Ainsi, la température des seconds matériaux d'accumulation thermique côté partie inférieure et supérieure (5a, 5b), est absorbée par les premiers matériaux d'accumulation thermique côté partie inférieure et supérieure (4a, 4b). La chaleur de solidification des premiers matériaux d'accumulation thermique côté partie inférieure et supérieure est thermiquement conduite à l'intérieur du contenant interne, lequel est maintenu à une température prédéfinie, permettant ainsi de de maintenir et gérer les matières ainsi admises à une température prédéfinie.
PCT/JP2012/066527 2011-06-28 2012-06-28 Système de gestion de température WO2013002324A1 (fr)

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JP2011143449A JP5759805B2 (ja) 2011-06-28 2011-06-28 温度管理システム

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JP6639234B2 (ja) * 2013-12-25 2020-02-05 アイ・ティ・イー株式会社 保冷システム
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JP6626299B2 (ja) * 2015-09-25 2019-12-25 株式会社 スギヤマゲン 定温輸送容器
CN108190244A (zh) * 2017-12-28 2018-06-22 广州齐天冷链科技有限公司 一种无源式采集水样的运输冷藏装置
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JP7205740B2 (ja) * 2018-06-29 2023-01-17 大日本印刷株式会社 保冷保温容器およびカゴ台車付き保冷保温容器
JP2020037446A (ja) 2018-09-06 2020-03-12 パナソニックIpマネジメント株式会社 収納箱
JP2020037445A (ja) 2018-09-06 2020-03-12 パナソニックIpマネジメント株式会社 保温容器
CN110386330B (zh) * 2019-08-20 2021-02-05 刘云飞 一种检验科的便携式采血箱
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