WO2012167893A1

WO2012167893A1 - Atomiser for a liquid

Info

Publication number: WO2012167893A1
Application number: PCT/EP2012/002337
Authority: WO
Inventors: Jörn-Ole HANSEN
Original assignee: G. Pohl-Boskamp Gmbh & Co. Kg
Priority date: 2011-06-10
Filing date: 2012-06-01
Publication date: 2012-12-13
Also published as: DE102011106138A1

Abstract

The invention relates to an atomiser for a liquid, in particular a pocket atomiser (10) for acute treatment of angina pectoris with a nitroglycerin solution, comprising a container (12) receiving the liquid, and a metering and spray device (16) that has a suction tube (32) immersed in the liquid. In order, in particular in the case of a container (12) having a convexly upwardly arched base (20), reliably to prevent the lower end of the suction tube (32) from becoming positioned on the container base (20) and a resulting blockage of a suction opening (62) of the suction tube (32), according to the invention the atomiser (10) comprises a diverter element (64) fastened to the suction tube (32) or to another part of the metering and spray device (16). Irrespective of the particular orientation of the atomiser (10) the diverter element (64) exerts a force on the suction tube (32) in a constant direction and bends same to one side.

Description

Atomizer for a liquid

The invention relates to a nebulizer for a liquid according to the preamble of claim 1. The invention relates in particular to a nebulizer for a therapeutic

Liquid and more particularly a pocket atomizer for the acute treatment of angina pectoris with a solution of nitroglycerin. Pocket atomizers for the acute treatment of angina pectoris with a nitroglycerin solution have long been marketed by the Applicant. In these pocket atomizers, the container has the form of a small glass or plastic bottle, the opening of which is closed by a dosing and spraying device mounted on the neck of the bottle. The metering and spraying device comprises an integrated piston pump, which allows sucking the suction stroke of the pump nitroglycerin solution from the container into a metering chamber and deliver a precisely metered amount of nitroglycerin solution in the discharge stroke, which displaced by the volume of the metering chamber

Nitroglycerin solution is set. The nitroglycerin solution is aspirated through the flexible suction or riser and dispensed through a spray nozzle of the metering and spraying device in the form of an aerosol spray, which is directed for administration to the underside of the patient's tongue.

The metering and spraying devices of these pocket sprayers are produced in large quantities since pocket sprayers of this type are used not only for the acute treatment of angina pectoris but for many other uses, such as for administering other drugs or for spraying perfume. In particular, in the latter case, it is desirable to empty the container as completely as possible. As with small glass or plastic bottles of Bottom of the bottle is often curved slightly convex upward, with the apex of the vault is located near the longitudinal central axis of the bottle, collects at largely deflated

Bottle of the remaining contents of the bottle in an annular recess, the upwardly curved bottom along the

Surrounds peripheral wall of the bottle. To make it possible to emptying such a bottle as completely as possible, it is advantageous if the lower end of the suction tube is not in the center of the container, but within this annular recess.

For this purpose, the suction pipe of metering and spraying devices known atomizer often made of a flexible plastic, usually high density polyethylene (HDPE) and is supplied to the manufacturer of dosing and spraying equipment as a roll. This roll product takes over a certain storage period to a curvature, which is still maintained after the separation and assembly of the suction pipes in the metering and spraying, so that the suction pipes have an inherent curvature. The curvature causes the suction pipes after assembly of the metering and spraying on a container not just along the container central axis extend downwards, but are deflected to one side in the direction of the container wall. In Taschenzerstäubern for the acute treatment of angina pectoris such a deflection of the suction tube at the same time has the advantage that the lower end of the suction tube is not aligned perpendicular to the bottom of the container. As a result, there is a reduced risk of it being pressed against the bottom of the container around the suction opening due to manufacturing or assembly tolerances, thereby completely or partially blocking the suction opening, as shown in FIG. 8 of the drawing in a non-inventive embodiment

Pocket atomizer illustrated for explanation. However, the inherent curvature of the suction tube is not a fixed size, but is subject to considerable fluctuations. To the

For example, suction pipes from the inner circumference of the roll goods usually have a smaller radius of curvature than suction pipes which are separated from the outer periphery of the roll goods. As a result, it can not be predicted how great will be the radial distance of the lower Saugrohrendes from the longitudinal central axis of the container after mounting a metering and spraying device on a container and whether this distance will be sufficiently large to a placement of the lower Saugrohrendes on a curved To prevent container bottom with security.

In particular, when the suction tube is relatively short, as usual with pocket atomizers, the lower end of the suction tube will not or only slightly deflected away from the container longitudinal axis if the suction tube has a relatively large radius of curvature.

But also with suction pipes with a stronger inherent

Curvature may occur for placing the lower end on a convexly upwardly curved container bottom, for example, when the metering and spraying not on the

Container neck unscrewed, but by latching or

Crimping is attached to the edge of the container opening, as is the case with some machines, which are used by the applicant in the manufacture of pocket atomizers for the acute treatment of angina pectoris. In these machines, the metering and spraying device is released after insertion of the suction tube into the container opening and falls down to the stop against the edge of the container opening down, where it usually tilts to one side to rest. If the lower end of the suction pipe is seated in this tilted state of the metering and spraying on the convexly upwardly curved container bottom, it may happen that it remains in this position and blocking the suction against the container bottom is pressed, as shown in Fig. 8, while the metering and spraying device is then centered by a pre-crimper of the machine on the container. In order to prevent a blockage of the suction opening when placing the lower end of a suction tube of a liquid atomizer, it is already known not to separate the suction tube along a plane perpendicular to its longitudinal central axis or cut off, but along a concave curved cut surface, which is on both sides of a

The apex lying on the longitudinal central axis of the suction tube curves downwards. In this way it should be avoided that the lower end of the suction tube around the entire intake opening around with the container bottom into contact. However, since the peripheral wall of a flexible suction pipe is somewhat deformable, at least a partial blockage of the intake opening is not completely excluded. For atomizers for liquids to

Acute treatment of diseases, such as the aforementioned Taschenzerstäubern for the acute treatment of angina pectoris with a nitroglycerin solution, however, can already have a partial blockage of the intake serious consequences, since during the suction stroke an insufficient amount of nitroglycerin solution is sucked. Therefore, in these atomizers, even a partial blockage of the suction port must be precluded with a 100% certainty, i. she may even at 1

Million atomizers will not occur once.

From US-A-4, 273, 272 already a nebulizer for a liquid is known, in which at the lower end of a flexible, submerged in the suction tube, a Auslenkgewicht is mounted to deflect the suction pipe with an inclined atomizer, so that the suction opening at the free end of the suction pipe is always immersed in the liquid. Although with such a Auslenkgewicht can be relatively long suction pipes deflect, but not short suction tubes of Taschenzerstäubern, in their containers also only little space for a Auslenkgewicht is available. In addition, such a deflection weight, especially with vertically aligned container longitudinal central axis for fitting the lower end of the suction pipe lead to the bottom of the container. Not least, the intake manifold is subjected to bending and deformed with each change in the orientation of the container, which can lead to a kinking of the suction tube. Further, US-A-5,875,940 discloses a nebulizer for a

Liquid with a container made of plastic, in which a flexible suction tube formed by a molded into the container

Suction tube guide extends, which bends and deflects the suction pipe to one side. Aside from being one

Suction tube guide only in plastic container and not in

Glass container can be molded, is considered disadvantageous that the molding of the Saugrohrführung in the

Container causes an additional effort that to

Introducing the suction pipe in the guide a lot of tact is required and that the suction pipe must rotate when screwing the spray on the thread of the container within the guide about its longitudinal axis, where it is subject to considerable bending deformation. In the case of more brittle intake pipes, this can lead to breakage and, in the case of elastic intake pipes, to twisting and thus to closure of the intake pipe.

WO2005 / 113385 A2 discloses an atomizer in the form of a spray can with a suction tube immersed in the liquid, in which a pipe bend rotatably mounted within a container on a metering and spraying device bends the suction pipe depending on the orientation of the spray can so that it always immersed in the liquid. The pipe bend is provided with a weight so that it rotates in dependence on the orientation of the spray can around its longitudinal central axis and deforms the intake pipe firmly connected to the metering and spraying by changing directions of force changing the bending direction.

Proceeding from this, the present invention seeks to improve a nebulizer of the type mentioned in that a placement of the lower end of the suction pipe can always be prevented with certainty on a convexly upwardly curved container bottom and thereby caused blocking a suction port of the suction pipe.

This object is achieved by a suction pipe or at another part of the dosing and spraying device

fixed deflector, regardless of the respective orientation of the atomizer in a consistent

Direction, based on the suction pipe, exerts a force on the suction pipe and this bends to one side. A "force in a constant direction" is understood to mean a force whose force application point and force direction on

Suction tube remains the same, so that the suction tube is exposed to a change in the orientation of the atomizer no changed bending forces or deformation forces.

The invention is based on the idea that by such a forced bending and deflection of the suction tube in a defined direction and by a defined amount for a lateral minimum distance between the longitudinal central axis of the container and the lower end of the suction tube can be taken care of placing the lower End of the suction tube on a convexly upwardly curved container bottom and thereby causing blockage of the suction in each position of the container impossible. Especially if that A steering element according to an advantageous embodiment of

Invention is attached frictionally, so that it through

Frictional forces on the suction pipe and / or the dosing and

Sprayer is held, beyond such a deflector without any structural change to the metering and spraying or disassembly of parts of the metering and spraying after their preparation and before mounting on a container in a simple manner

subsequently attached and thereby a loss of

Manufacturer's warranty of the metering and spraying be avoided.

Advantageously, the deflecting element acts on an upper half of the suction pipe facing the metering and spraying device, preferably close to the upper end of the suction pipe, whereby the extent of bending of the suction pipe can be reduced with a corresponding lateral deflection of the lower end.

A preferred embodiment of the invention provides that the deflecting deflects the suction tube by a predetermined minimum of the longitudinal center axis of the container and / or the metering and spraying away. This minimum can be for

Example may be defined as a deflection angle between the longitudinal center axis of the suction tube above the baffle and the longitudinal center axis of the suction tube below the baffle which should be at least 10 degrees, preferably at least 15 and most preferably about 20 degrees.

Alternatively, the predetermined minimum amount of deflection of the suction pipe away from the longitudinal central axis of the container and / or the metering and spraying device may also be referred to as a radial distance between the center of the suction opening at the lower end of

Suction tube and the longitudinal center axis of the container and / or the metering and spraying be defined. This radial Spacing is desirably greater than 20%, preferably greater than 30% and most preferably greater than 40% of the inner diameter of the container. In both cases, the lower end of the suction tube is deflected far enough away from the center of a curved container bottom, so that it can no longer sit on the container bottom even with large manufacturing tolerances. To ensure that the lower end of the suction tube enters the container opening and does not abut against its boundary edge when it is during assembly of the dosing and

Sprayer is approached on the container to the container opening, however, the deflection of the suction pipe should not exceed a predetermined maximum. If the maximum deflection is stated as the deflection angle, it should be expediently less than 30 degrees, and preferably less than 25 degrees. If the maximum deflection is stated as the radial distance between the center of the suction opening at the lower end of the suction pipe and the longitudinal central axis of the container and / or the metering and spraying device, this should not exceed 50% and preferably not more than 40% of the inner diameter the container opening through which the suction pipe is inserted into the container.

A further preferred embodiment of the invention provides that the deflecting element is a pushed onto the suction pipe curved or kinked pipe or hose piece, which is advantageously made by injection molding of plastic.

For the production of the pipe or hose piece by injection molding a plastic is advantageously used, which is compatible with the therapeutic liquid in the container. Prefers the pipe or hose piece is made of the same material as the suction pipe, preferably high density polyethylene (HDPE).

To a demolding of the pipe or hose piece in the

To facilitate manufacture, the pipe or hose piece is preferably not bent but bent, wherein it consists of two integrally connected rectilinear

There are sections so that they can be deducted in the direction of their respective longitudinal central axis of the associated mandrel. The two sections are advantageously connected to each other along a flat buckling surface and expediently have approximately the same length.

The pipe or hose piece is preferably pushed with loose sliding or clearance fit on the suction tube, which expediently after pushing on the flexible elastic suction tube by the restoring forces or by the contact pressure of the outer circumference of the bent suction tube on both sides of the

Buckling surface against the inner circumference of the pipe or

Hose section and the frictional forces caused thereby frictionally held on the suction pipe.

A further advantageous embodiment of the invention provides that the pipe or hose piece is pushed from the free end of the suction pipe mounted on the metering and spraying device forth on the suction pipe and moved along the suction pipe upwards in the direction of the metering and spraying until it abuts against an end face of the metering and spraying device.

As already mentioned, the atomizer according to the invention is with particular advantage as a pocket atomizer for the acute treatment of angina pectoris with a nitroglycerin solution of a Container in the form of a small glass or plastic bottle (vial) with a convexly upwardly curved bottom suitable.

In the following the invention with reference to two in the

Drawing illustrated embodiments and a

Representation for clarification of the problem explained in more detail. Show it

Fig. 1 is a sectional view of an inventive

Taschenumstäubers with a suction tube and a tubular deflecting element for deflecting the suction tube;

2 is an enlarged perspective view of

Deflecting element;

3 is an enlarged side view of the deflecting element; 4 is an enlarged sectional view of the deflecting element; Fig. 5 is a sectional view of another invention

Taschenzerstäubers with a sleeve-shaped deflector for deflecting the suction tube;

6 is an enlarged perspective view of

Deflection element of Fig. 5;

Fig. 7 is a bottom view of the deflector of Figs. 5 and 6; Fig. 8 is a sectional view of a non-inventive

Pocket atomizer to explain the problem.

The illustrated in Figures 1, 5 and 8 of the drawing

Pocket atomizers 10 are for nebulizing a therapeutic Fluid (not shown), which is a nitroglycerin solution for the acute treatment of angina

Pectoris can act. The pocket atomizers 10 consist essentially of a small bottle (vial) 12 made of glass or plastic, as well as a mounted on a neck 14 of the bottle 12 metering and spray head 16, which has a filling opening at the top of the

Bottle neck 14 closes liquid-tight.

The bottle 12 has a rotationally symmetrical, to a longitudinal central axis 18 of the bottle 12 and the metering and

Spray head 16 coaxial shape with a convex upwardly into the interior of the bottle 12 curved bottom 20, whose apex lies on the longitudinal central axis 18.

The metering and spraying head 16 essentially comprises a holder 22 which is sealingly but rotatably connected to the bottle neck 14 and made by injection molding of plastic, likewise an actuating member 24 which is produced by injection molding from plastic and provided with a spray nozzle 26, counter to the force of a spring 28 in the interior of the holder 22 displaceable piston 30, and a suction pipe 32 for sucking liquid from the bottle 12 into the metering and spray head sixteenth

The holder 22 has a downwardly projecting into the interior of the bottle 12 hollow tubular extension 34 which, like the rest of the holder 22 is coaxial with the longitudinal center axis 18 and tapers down to stepwise. A middle part 36 of the extension 34 surrounds a metering chamber 38. The metering chamber 38 contains a ball 40, which in the upright position of the atomizer 10 shown in FIG. 1 against a conically downwardly tapered valve seat 42 at the bottom End of the metering chamber 38 is applied and the metering chamber 38 closes there liquid-tight. Below the valve seat 42, the extension 34 has a tubular cylindrical end portion 44.

The actuator 24 is rigid with the upper end of the

Piston 30 is connected so that it moves together with the actuator 24, but with respect to

Bracket 22 about the longitudinal central axis 18 rotatable. The

Actuator 24 surrounds a downwardly open recess 46 into which the upper end of the piston 30 projects. Above the upper end of the piston 30, a plug 48 is slidably inserted into the recess 46, which is pressed by a helical compression spring 50 sealingly against the upper end of the piston 30. The plug 48 is surrounded by an annular gap 52, which is recessed by a recessed within the actuator 24 outlet channel 54 with the side of the actuator 24th

arranged spray nozzle 26 and an outlet opening of the

Spray nozzle 26 communicates.

The extended lower part of the piston 30 projects from above into the metering chamber 38, in which it is displaceable while sealing against the cylindrical peripheral wall of the metering chamber 38. The arranged in the metering chamber 38 spring 28 is a helical compression spring, which is supported against the valve seat 42 and up against the piston 30 and the downward movement of the piston 30 during depression of the

Actuator 24 counteracts. The downward movement of the piston 30 is limited by a stop surface 60 of the holder 22, against which the actuating member 24 abuts in the lower end position of the piston 30. At discharge of the

Actuator 24, the piston 30 and the associated with this actuator 24 by the spring 28 back up into its illustrated in Fig. 1 unactivated resting or Starting position moved back. The piston 30 surrounds a central fluid channel 58 which passes through the piston 30 along the longitudinal central axis 18 over its entire length. The high-density polyethylene suction pipe 32 is press-fitted into the tubular lower end portion 44 of the bracket 22 at its upper end and provided with a suction port 62 at its lower end. Other than shown in the drawing, the lower end of the suction tube 32 may be limited instead of a flat sectional surface of a concave curved sectional surface which curves down on both sides of a lying on the longitudinal central axis of the suction tube 32 apex. In order to prevent the lower end of the flexible suction tube 32 during assembly of the metering and spraying head 16 or during later use of the atomizer 10 with complete or partial blocking of the suction port 62 on the upwardly curved bottom 20 of the bottle 12 touches, like this is shown in Fig. 8 to illustrate the problem, the dosing and spray head 16 is provided after its manufacture and prior to its mounting on the bottle 12 with a deflector 64 to bend the suction tube 32 below the tubular lower end portion of the holder 22 and thereby deflecting by a defined amount to one side from the longitudinal central axis 18 of the bottle 12 and the metering and spraying head 16, as shown in Fig. 1 and 5.

In the deflecting element 64 shown in Figures 1 to 4 is a kinked piece of pipe 66 which is pushed from the lower end of the suction tube 32 ago this until it abuts against an annular end face 68 of the tubular end portion 44 of the extension 34, such as shown in Fig. 1. The bent pipe piece 66 produced by injection molding of high-density polyethylene (HDPE) consists of two

same length straight cylindrical tube sections 70, 72 with the same inner and outer diameter, which are integrally connected along a kink plane 74, as best shown in Fig. 2, 3 and 4. The inner diameter of the two pipe sections 70, 72 is slightly larger than the outer diameter of the suction pipe 32, so that the lower end of the suction pipe 32 with play in the end portion 70 can be inserted. When the lower end of the suction tube 32 passes the kinked plane 74, however, the suction tube 32 is slightly bent at this point and elastically deformed, whereby it on both sides of the kinking plane 74 due to a resulting from the deformation elastic restoring force with its outer periphery something against the inner circumference of Pipe piece 66 is pressed. This has the consequence that the completely pushed onto the suction pipe 32 pipe piece 66 is held by the frictional force between its inner periphery and the outer circumference of the suction pipe 32 thereon.

As shown in FIG. 4, the two pipe sections 70, 72 each have a longitudinal central axis 76, 78 and a flat end face 80, 82 perpendicular to this longitudinal central axis 76, 78. The kink plane 74 is related to each of the two

End faces 80, 82 at an angle of about 10 degrees

inclined so that the longitudinal center axes 76, 78 of the two

Pipe sections 70, 72 are inclined at an acute deflection angle of about 20 degrees to each other and, accordingly, the suction pipe 32 within the pipe section 66 by about 20 degrees from the

Longitudinal axis 18 of the metering and spray head 16 and the

Bottle 12 is deflected away. By this deflection, the lower end of the suction tube 32 always has a certain minimum radial distance from the longitudinal central axis 18, the one Placement of the lower end of the suction tube 32 on the curved bottle bottom 20 prevents.

The deflector 64 shown in Figs. 5-7 is a hollow cylindrical sleeve 84 which is also made by high density polyethylene injection molding having an open top end and a partially closed bottom end provided with an eccentric circular aperture 86. The open end is press-fitted onto the tubular lower end portion 44 of the extension 34 of the bracket 22, which receives the upper end of the suction tube 32. Before attaching the sleeve 84 to the end portion 44, the lower end of the suction tube 32 is passed through the eccentric opening 86. After attaching the sleeve 84, the edge of the opening 86 externally exerts a lateral force on the suction tube 32, so that it is deflected in the direction of the offset of the opening 86, as shown in Fig. 5. The degree of deflection corresponds to that in FIG. 1.

The operation of the nebulizer 10 is as follows: When the actuator 24 is depressed in the upright position of the nebulizer 10 shown in Figures 1 and 5 by a downward force and thereby the piston 30th

is moved downward in the metering chamber 38 against the force of the return spring 28, which is at a preceding

Suction stroke of the piston 30 sucked into the metering chamber 38

Liquid displaced upwardly through the liquid passage 58 of the piston from the metering chamber 38. The pressurized displaced liquid raises the plug 48 against the force of the compression coil spring 50 from the upper end of the plug

From piston 30 and then flows through the annular gap 52 and the outlet channel 54 to the spray nozzle 26 through which it exits as aerosol spray. Upon discharge of the actuator 24, the piston 30 is moved by the force of the return spring 28 back up, wherein 32 liquid from the bottle 12 is sucked into the interior of the metering chamber 38 through the suction tube. When the piston 30 reaches its upper end position shown in the drawing, the ball 40 prevents leakage of the fluid located in the metering chamber 38. As a result, during the subsequent depression of the piston 30, a precisely metered quantity of the liquid can be displaced from the metering chamber 38 and discharged through the spray nozzle 26.

When the container 12 is largely emptied, can

Remaining emptying the actuator 24 are rotated with the spray nozzle 26 about the longitudinal central axis 18 in such a position that the lower end 62 of the suction pipe 32 in the

Liquid is immersed when the container 12 is brought into a slight tilt during the discharge of the liquid. When the spray nozzle 26 is to be directed slightly upwards in the discharge of the liquid, the actuator 24 is rotated with the spray nozzle 26 shown in FIG. 1 position in which the suction tube 32 relative to the longitudinal center axis 18 in a direction opposite to the spray nozzle 26 direction is distracted.

Conversely, the actuator 24 is rotated with the spray nozzle 26 in a position in which the suction pipe 32 is deflected relative to the longitudinal center axis 18 in the same direction as the spray nozzle 26 when the spray nozzle 26 at the delivery of the

Liquid should be directed slightly downwards. As the actuator 24 and spray nozzle 26 rotate, the remainder of the metering and spray head 16, as well as the suction tube, remain stationary with respect to the container 12.

Claims

claims

1. atomizer for a liquid, in particular for

Acute treatment of angina pectoris with a nitroglycerin solution, with a liquid receiving container and with a metering and spraying device, wherein the metering and spraying device comprises a flexible suction tube immersed in the liquid, characterized by a suction tube (32) or on a other part of the dosing and spraying device (16) fixed deflecting element (64), regardless of

respective orientation of the atomizer (10) in a constant direction exerts a force on the suction tube (32) and this bends to one side.

2. Atomizer according to claim 1, characterized in that the deflecting element (64) is frictionally mounted on the suction pipe (32) or on another part (44) of the metering and spraying device (16).

3. Atomizer according to claim 1 or 2, characterized in that the deflecting element (64) the suction pipe (64) to a

predetermined amount of a longitudinal central axis (18) of the container (12) and / or the metering and spraying (16) away

deflects.

4. Atomizer according to one of the preceding claims, characterized in that a deflection angle () between

Longitudinal center axes (76, 78) of the suction tube (32)

opposite ends of the deflector (64) between 15 and

40 degrees.

5. Atomizer according to one of the preceding claims, characterized in that the deflection element (64) acts on an upper half of the suction tube (32).

6. Atomizer according to one of the preceding claims, characterized in that the deflection element (64) on the

Suction pipe (32) deferred curved or kinked Rohroder hose piece (66).

7. An atomiser according to claim 6, characterized in that the tube or hose piece (66) with a sliding or clearance fit on the suction tube (32) is pushed and by frictional forces between an outer circumference of the bent suction tube (32) and an inner circumference of the Pipe or hose piece (66) on the suction pipe (32) is held.

8. An atomiser according to one of the preceding claims, characterized in that the deflecting element (64) consists of the same

Material as the suction pipe (32) consists.

9. Atomiser according to one of the preceding claims, characterized in that the deflecting element (64) has a

Passage opening (86) for the suction pipe (32).

10. Atomizer according to one of the preceding claims, characterized in that the container (12) has a convexly upwardly curved bottom (20).

11. An atomiser according to one of the preceding claims, characterized in that the deflecting element (64) with respect to

Metering and spraying device (16) is immovable.

12. Atomizer according to one of the preceding claims, characterized in that one with a spray nozzle (26) provided Actuator (24) of the metering and spraying device (16) about a longitudinal central axis (18) of the container (12) and / or the metering and spraying device (16) is rotatable.

13. An atomiser according to claim 12, characterized in that the suction tube (32) during the rotation of the actuating member (24) with respect to the container (12) remains stationary.

Atomizer according to one of the preceding claims, characterized in that the container (12) contains a nitroglycerin solution for the acute treatment of angina pectoris.