WO2012165854A3 - 표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ - Google Patents

표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ Download PDF

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WO2012165854A3
WO2012165854A3 PCT/KR2012/004259 KR2012004259W WO2012165854A3 WO 2012165854 A3 WO2012165854 A3 WO 2012165854A3 KR 2012004259 W KR2012004259 W KR 2012004259W WO 2012165854 A3 WO2012165854 A3 WO 2012165854A3
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expression
target genes
immune reaction
inhibition
interfering dsrna
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PCT/KR2012/004259
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French (fr)
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WO2012165854A9 (ko
WO2012165854A2 (ko
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이동기
장찬일
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성균관대학교산학협력단
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Priority to US14/123,056 priority Critical patent/US20140249304A1/en
Publication of WO2012165854A2 publication Critical patent/WO2012165854A2/ko
Publication of WO2012165854A3 publication Critical patent/WO2012165854A3/ko
Publication of WO2012165854A9 publication Critical patent/WO2012165854A9/ko

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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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Abstract

본 발명은 RNAi-매개 특정 표적 유전자 발현을 억제할 뿐만 아니라 면역 반응을 촉진할 수 있는 이중가닥의 긴 간섭 RNA 구조(long interfering dsRNA, liRNA) 및 그 용도에 관한 것으로, 보다 상세하게는, 서열 특이적으로 RNA 간섭 반응을 통해 특정 표적 유전자의 발현을 억제시킬 뿐만 아니라, 구조 의존적으로 단백질 키나아제 R (PKR) 경로를 자극시켜 인터페론 β의 발현을 유도할 수 있는 이중가닥의 긴 간섭 RNA 구조에 관한 것이다.
PCT/KR2012/004259 2011-05-30 2012-05-30 표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ WO2012165854A2 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US14/123,056 US20140249304A1 (en) 2011-05-30 2012-05-30 Long interfering dsrna simultaneously inducing an immune reaction and the inhibition of the expression of target genes

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2011-0051641 2011-05-30
KR1020110051641A KR101590586B1 (ko) 2011-05-30 2011-05-30 표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ

Publications (3)

Publication Number Publication Date
WO2012165854A2 WO2012165854A2 (ko) 2012-12-06
WO2012165854A3 true WO2012165854A3 (ko) 2013-03-28
WO2012165854A9 WO2012165854A9 (ko) 2013-05-23

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PCT/KR2012/004259 WO2012165854A2 (ko) 2011-05-30 2012-05-30 표적 유전자 발현 억제 및 면역 반응을 동시에 유발하는 이중가닥의 긴 간섭 ｒｎａ

Country Status (3)

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US (1) US20140249304A1 (ko)
KR (1) KR101590586B1 (ko)
WO (1) WO2012165854A2 (ko)

Families Citing this family (11)

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WO2010090452A2 (ko) * 2009-02-04 2010-08-12 성균관대학교산학협력단 세포 내 전달능이 증가된 작은 간섭 rna 복합체
EP2631291B1 (en) 2010-10-22 2019-05-15 OliX Pharmaceuticals, Inc. Nucleic acid molecules inducing rna interference, and uses thereof
CN104755620B (zh) 2012-05-22 2018-03-02 奥利克斯医药有限公司 具有细胞内穿透能力的诱导rna干扰的核酸分子及其用途
SK500652015A3 (sk) * 2015-10-15 2017-05-03 Ústav Polymérov Sav Spôsob úpravy funkčného stavu ľubovoľnej mRNA umožňujúci jej selektívne a špecifické rozpoznanie
EP3377630A4 (en) 2015-11-16 2020-01-01 Olix Pharmaceuticals, Inc. TREATMENT OF AGE-RELATED MACULAR DEGENERATION USING RNA COMPLEXES THAT TARGET MYD88 OR TLR3
KR20180104692A (ko) 2016-02-02 2018-09-21 올릭스 주식회사 Angpt2 및 pdgfb를 표적화하는 rna 복합체를 사용하는 혈관신생 관련 질환의 치료
CN108779463B (zh) 2016-02-02 2022-05-24 奥利克斯医药有限公司 使用靶向IL4Rα、TRPA1或F2RL1的RNA复合物治疗特应性皮炎和哮喘
CA3020487C (en) 2016-04-11 2022-05-31 Olix Pharmaceuticals, Inc. Treatment of idiopathic pulmonary fibrosis using rna complexes that target connective tissue growth factor
KR101916652B1 (ko) 2016-06-29 2018-11-08 올릭스 주식회사 작은 간섭 rna의 rna 간섭효과 증진용 화합물 및 이의 용도
CN110770343A (zh) * 2017-02-10 2020-02-07 成均馆大学校产学协力团 用于rna干扰的长双链rna
US20230095192A1 (en) * 2020-03-03 2023-03-30 University Of Washington Synthetic agonists of dna-pk and their use

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WO2007107162A2 (en) * 2006-03-23 2007-09-27 Santaris Pharma A/S Small internally segmented interfering rna
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Also Published As

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US20140249304A1 (en) 2014-09-04
KR20120133127A (ko) 2012-12-10
WO2012165854A9 (ko) 2013-05-23
WO2012165854A2 (ko) 2012-12-06
KR101590586B1 (ko) 2016-02-01

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