WO2012144799A3 - 활성 폴리펩타이드의 결합 친화력 및 결합 특이성을 증강시키는 단백질 골격 모듈 - Google Patents

활성 폴리펩타이드의 결합 친화력 및 결합 특이성을 증강시키는 단백질 골격 모듈 Download PDF

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Publication number
WO2012144799A3
WO2012144799A3 PCT/KR2012/002958 KR2012002958W WO2012144799A3 WO 2012144799 A3 WO2012144799 A3 WO 2012144799A3 KR 2012002958 W KR2012002958 W KR 2012002958W WO 2012144799 A3 WO2012144799 A3 WO 2012144799A3
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WO
WIPO (PCT)
Prior art keywords
increases
active polypeptides
polypeptides
binding
binding affinity
Prior art date
Application number
PCT/KR2012/002958
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English (en)
French (fr)
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WO2012144799A2 (ko
Inventor
차기원
소인섭
김소연
이병헌
김인산
Original Assignee
경북대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by 경북대학교 산학협력단 filed Critical 경북대학교 산학협력단
Priority to CN201280029758.7A priority Critical patent/CN103703022A/zh
Priority to EP12773577.7A priority patent/EP2700649B1/en
Priority to JP2014506324A priority patent/JP6050319B2/ja
Publication of WO2012144799A2 publication Critical patent/WO2012144799A2/ko
Publication of WO2012144799A3 publication Critical patent/WO2012144799A3/ko
Priority to US14/057,654 priority patent/US8975369B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/485—Epidermal growth factor [EGF] (urogastrone)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/5406—IL-4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Abstract

본 발명은 활성 폴리펩타이드의 결합 친화력 또는 결합 특이성을 증강시키는 신규한 단백질 골격 모들에 관한것으로， 보다 상세하게는 서열번호 1로 표시되는 아미노산 서열의 1번째 내지 19번째 아미노산 서열로 이루어진 폴리펩타이드; 활성폴리펩타이드를 포함하는 폴리펩타이드; 및 서열번호 1로 표시되는 아미노산 서열의 29번째 내지 86번째 아미노산 서열로 이루어진 폴리펩타이드를 포함하는 것을 특징으로 하는 단백질 골격 모들 및 이의 제조방법에 관한 것이다. 본 발명의 단백질 골격 모들은 내장된 활성 폴리펩타이드의 결합 친화력 또는 결합 특이성을 증강 시키므로 질병의 진단 및 치료에 효과적이다.
PCT/KR2012/002958 2011-04-18 2012-04-18 활성 폴리펩타이드의 결합 친화력 및 결합 특이성을 증강시키는 단백질 골격 모듈 WO2012144799A2 (ko)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CN201280029758.7A CN103703022A (zh) 2011-04-18 2012-04-18 使活性多肽的结合亲和力和结合特异性增强的蛋白质骨架模块
EP12773577.7A EP2700649B1 (en) 2011-04-18 2012-04-18 Protein skeletal module which increases the binding affinity and binding specificity of active polypeptides
JP2014506324A JP6050319B2 (ja) 2011-04-18 2012-04-18 活性ポリペプチドの結合親和力及び結合特異性を増強させる蛋白質骨格モジュール
US14/057,654 US8975369B2 (en) 2011-04-18 2013-10-18 Protein skeletal module which increases the binding affinity and binding specificity of active polypeptides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110035613A KR101818759B1 (ko) 2011-04-18 2011-04-18 활성 폴리펩타이드의 결합 친화력 및 결합 특이성을 증강시키는 단백질 골격 모듈
KR10-2011-0035613 2011-04-18

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US14/057,654 Continuation US8975369B2 (en) 2011-04-18 2013-10-18 Protein skeletal module which increases the binding affinity and binding specificity of active polypeptides

Publications (2)

Publication Number Publication Date
WO2012144799A2 WO2012144799A2 (ko) 2012-10-26
WO2012144799A3 true WO2012144799A3 (ko) 2013-01-17

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2012/002958 WO2012144799A2 (ko) 2011-04-18 2012-04-18 활성 폴리펩타이드의 결합 친화력 및 결합 특이성을 증강시키는 단백질 골격 모듈

Country Status (6)

Country Link
US (1) US8975369B2 (ko)
EP (1) EP2700649B1 (ko)
JP (1) JP6050319B2 (ko)
KR (1) KR101818759B1 (ko)
CN (1) CN103703022A (ko)
WO (1) WO2012144799A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014123399A1 (ko) * 2013-02-08 2014-08-14 경북대학교 산학협력단 인간 페리틴 유래 융합폴리펩티드
KR102028250B1 (ko) * 2017-10-17 2019-11-04 전북대학교산학협력단 대장균 선별용 펩타이드
CN112289372B (zh) * 2020-12-15 2022-04-22 武汉华美生物工程有限公司 一种基于深度学习的蛋白质结构设计方法及装置

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AU2002246808A1 (en) * 2000-12-19 2002-08-06 Curagen Corporation Human nucleic acids and polypeptides and methods of use thereof
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Also Published As

Publication number Publication date
CN103703022A (zh) 2014-04-02
KR20120118186A (ko) 2012-10-26
US8975369B2 (en) 2015-03-10
JP2014519313A (ja) 2014-08-14
US20140079643A1 (en) 2014-03-20
WO2012144799A2 (ko) 2012-10-26
JP6050319B2 (ja) 2016-12-21
EP2700649A2 (en) 2014-02-26
KR101818759B1 (ko) 2018-01-16
EP2700649B1 (en) 2016-12-21
EP2700649A4 (en) 2014-12-24

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