WO2012131931A1 - Matière de recouvrement de plaie - Google Patents

Matière de recouvrement de plaie Download PDF

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Publication number
WO2012131931A1
WO2012131931A1 PCT/JP2011/057981 JP2011057981W WO2012131931A1 WO 2012131931 A1 WO2012131931 A1 WO 2012131931A1 JP 2011057981 W JP2011057981 W JP 2011057981W WO 2012131931 A1 WO2012131931 A1 WO 2012131931A1
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WO
WIPO (PCT)
Prior art keywords
layer
fiber
wound
wound dressing
film layer
Prior art date
Application number
PCT/JP2011/057981
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English (en)
Japanese (ja)
Inventor
誠吾 檜垣
Original Assignee
ダイワボウホールディングス株式会社
ダイワボウノイ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by ダイワボウホールディングス株式会社, ダイワボウノイ株式会社 filed Critical ダイワボウホールディングス株式会社
Priority to PCT/JP2011/057981 priority Critical patent/WO2012131931A1/fr
Priority to JP2013506938A priority patent/JPWO2012131931A1/ja
Priority to CN201180069828.7A priority patent/CN103501827B/zh
Publication of WO2012131931A1 publication Critical patent/WO2012131931A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/425—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

Definitions

  • the present invention relates to a wound dressing that covers a human or animal wound to promote recovery.
  • Patent Document 1 discloses a low adhesion wound comprising a laminate having an intermediate absorbent layer between two outer layers, the absorbent layer being a hydrophilic foam, and the two outer layers being elastically stretchable.
  • a protective material is disclosed. This protective material for low-adhesion wounds is excellent in that it does not adhere to the wound because it covers the wound and at the same time the intermediate absorbent layer serves to absorb exudate from the wound.
  • Patent Document 2 discloses a wound dressing material comprising a laminate of a film formed with polyurethane resin and having an aperture formed therein and a nonwoven fabric having elasticity, and the film or the nonwoven fabric contains an antibacterial agent.
  • antibacterial agents antibacterial agents effective against Pseudomonas aeruginosa, Enterobacter, Klebsiella, Staphylococcus, etc., such as sulfa, cephalosporins, penicillins, nalidixins, macrolides, etc. are disclosed. ing.
  • Patent Document 3 discloses an antipruritic, antipruritic and anti-inflammatory agent containing a metal phthalocyanine derivative as an active ingredient. A poultice obtained by kneading this active ingredient in fiber powder is applied to gauze and applied to the affected area for pouring.
  • JP 59-11862 A Japanese Patent No. 2993170 Japanese Examined Patent Publication No. 7-68128
  • Patent Document 1 does not adhere to the wound while protecting and protecting the wound from the outside, but does not have a function of actively healing.
  • the wound dressing of Patent Document 2 can be expected to suppress bacteria for the time being by the disclosed antibacterial agent, clinical data on whether it is actually effective against the exemplified bacteria listed in Patent Document 2 Is not listed.
  • the antipruritic, antipruritic and anti-inflammatory agents of Patent Document 3 are recognized to have an effect on wounds and inflammation, there are problems such as complicated gauze replacement work and pain to patients.
  • the present invention has been made to solve the above problems, and is a wound dressing that protects a wound from the outside without adhering to the wound and can be easily replaced without causing pain to the patient. It aims at providing what is equipped with the function made to heal.
  • the inventor of the present invention has continually studied the medicinal effects of the metal phthalocyanine derivatives described in Patent Document 3, and as a result, found that mercaptan gas is generated by bacteria growing in the wound and stimulates the wound to induce gangrene.
  • the present invention has been completed.
  • the wound dressing according to claim 1, which has been made to achieve the above object, is a film layer in which a surface in contact with a wound has an opening, and an upper surface of the film layer includes: Formula I (Wherein M is a metal selected from Fe, Co, Mn, Ti, V, Ni, Cu, Zn, Mo, W, Os, and R 1 , R 2 , R 3 and R 4 are the same or different ⁇
  • a fiber layer comprising a fiber carrying a metal phthalocyanine derivative represented by COOH group or —SO 3 H group, and n1, n2, n3 and n4 are 0 to 4 and 1 ⁇ n1 + n2 + n3 + n4 ⁇ 8)
  • the liquid absorber layer is laminated on the upper surface of the fiber layer.
  • the wound dressing described in claim 2 is the wound dressing described in claim 1, and is effective for gas gangrene caused by mercaptan gas.
  • the wound dressing according to claim 3 is the wound dressing according to claim 1 or 2, wherein the film layer is formed by laminating at least two resin layers, and the two of the two resin layers.
  • the surface in contact with the wound is a high-melting point resin layer
  • the surface in contact with the fiber layer is a low-melting point resin layer
  • the fiber layer includes heat-adhesive fibers
  • the film layer and the fiber layer are heat-bonded. It is characterized by.
  • a wound dressing according to claim 4 is the wound dressing according to claim 1, 2, or 3, wherein the liquid absorbent layer is made of a nonwoven fabric, a woven fabric, or a foam.
  • the wound dressing according to claim 5 is the wound dressing according to claim 1, 2, 3 or 4, wherein the fiber layer and the liquid absorber layer are integrated by hydroentanglement treatment. It is a hydroentangled nonwoven fabric.
  • the wound dressing material of the present invention adopts the above-described configuration, so that it can absorb the exudate effectively without adhering to the wound part, and can prevent malodor and suppuration of the wound caused by mercaptan gas or the like.
  • the metal phthalocyanine derivative has a function of decomposing mercaptans, and has gas deodorizing properties and antibacterial properties. Therefore, it is useful as a therapeutic agent for infection wounds caused by mercaptan gas.
  • Infected wounds caused by gas that is, gas gangrene, grows in tissues where gas-producing bacteria have invaded tissues from wounds such as trauma wounds, burn wounds, surgical wounds, pressure sores (bed sores), diabetic gangrene, etc. Occurs and affects the whole body by creating toxins.
  • the gas and toxins generated by the bacteria infected with the wound in this way invade normal cells to create a rot state and become pus.
  • the wound dressing material including the fiber carrying the metal phthalocyanine derivative of the present invention has deodorant and antibacterial properties, it suppresses the growth of bacteria, and normal cells are less active due to gas such as mercaptan. Suppress and prevent.
  • the wound dressing of the present invention is a laminate comprising a film layer / fiber layer / liquid absorber layer, and is used so that the surface of the film layer is in contact with human skin.
  • the film layer is perforated and breathable.
  • the size of the hole is preferably about 0.05 to 2 mm 2 , and the shape is not particularly limited, such as a circle, a rectangle, or a polygon.
  • the material (polymer) constituting the film layer is a polyolefin such as polyethylene or polypropylene, a polyethylene terephthalate, a polybutylene terephthalate, a polyester such as polylactic acid, a polyamide such as nylon 6 or nylon 66, a polymer such as polyurethane, or a copolymer thereof. Two or more can be used.
  • the film layer is preferably formed by laminating two or more resin layers, the surface side in contact with the wound is a high melting point resin layer, and the surface in contact with the fiber layer is a low melting point resin layer.
  • a combination of laminated structures for example, polypropylene / polyethylene, polyester / polyethylene, or the like is used.
  • the film By making the film into a laminated structure, it can be thermally bonded to the fiber layer while having openings, so that the covering material does not move or the layers are not peeled against the movement of the patient. Further, when the wound dressing is cut to a predetermined size, the short fibers constituting the fiber layer are prevented from falling off from the cut surface. Therefore, not only the cleanliness in the medical site such as a treatment room is lowered, but also the occurrence of shed fibers that are likely to become an infection source, that is, the occurrence of lint is small, so that the infection caused by the occurrence of lint can be prevented.
  • the film layer preferably has a basis weight of 5 to 40 g / m 2 . More preferably, it is 10 to 20 g / m 2 .
  • basis weight of the film layer is within the above range, exudate from the wound easily penetrates and the feeling of use is good.
  • This film layer does not absorb exudate such as blood, pus, etc., but allows the exudate to permeate through the pores of the film, so that it hardly adheres to the wound and does not cause discomfort to the patient.
  • the film layer is simply laminated with the fiber layer or joined to the fiber layer.
  • a method for bonding to the fiber layer for example, a method of bonding by applying or impregnating a binder resin, a method of bonding by thermal bonding, a method of bonding by entanglement treatment, or the like is used.
  • the fiber layer has gas deodorant and antibacterial properties, and the following formula I (Wherein M is a metal selected from Fe, Co, Mn, Ti, V, Ni, Cu, Zn, Mo, W, Os, and R 1 , R 2 , R 3 and R 4 are the same or different ⁇ COOH group or —SO 3 H group, and n1, n2, n3 and n4 are fibers containing a metal phthalocyanine derivative represented by 0 to 4 and 1 ⁇ n1 + n2 + n3 + n4 ⁇ 8).
  • the metal phthalocyanine derivative serving as an active ingredient is represented by the following formula II when M is Co, R 1 and R 3 are —COOH groups It becomes the structure shown in.
  • the metal phthalocyanine derivative has the following formula III when M is Fe, R 1 , R 2 , R 3 and R 4 are all —COOH groups, and n1, n2, n3 and n4 are each 1 It becomes the structure shown in.
  • This iron phthalocyanine tetracarboxylic acid can be synthesized as follows. Trimellitic anhydride, urea, ammonium molybdate, and ferric chloride anhydride are added to nitrobenzene, stirred, and heated to reflux to obtain a precipitate. The obtained precipitate is hydrolyzed by adding an alkali, and then acidified by adding an acid.
  • the metal phthalocyanine derivative has the following formula IV when M is Fe, R 1 , R 2 , R 3 , and R 4 are all —COOH groups, and n1, n2, n3, and n4 are each 2, It becomes the structure shown in.
  • the metal phthalocyanine derivative represented by the formula I is represented by the following formula V when M is Co and R 1 and R 3 are —SO 3 H groups: It becomes the structure shown in.
  • the metal phthalocyanine derivative has the following formula VI when M is Fe, R 1 , R 2 , R 3 and R 4 are —SO 3 H groups: It becomes the structure shown in.
  • metal phthalocyanine derivatives are produced by a known method, and are marketed as functional substances having enzyme-like functions including dyes.
  • enzyme-like functions including dyes.
  • iron phthalocyanine tetracarboxylic acid, trimellitic anhydride, urea, ammonium molybdate, and ferric chloride anhydride are added to nitrobenzene, stirred, heated to reflux, and a precipitate is obtained. It can be obtained by adding an alkali to the product to hydrolyze it, and then adding acid to make it acidic.
  • Cobalt phthalocyanine octacarboxylic acid is a similar method using pyromellitic anhydride instead of trimellitic anhydride, which is a raw material of iron phthalocyanine tetracarboxylic acid, and ferric chloride instead of ferric chloride anhydride. Can be manufactured.
  • the central metal M of the metal phthalocyanine derivative is selected from Fe, Co, Mn, Ti, V, Ni, Cu, Zn, Mo, W, and Os, but in terms of deodorizing property, antibacterial property, and biocompatibility Fe or Co is preferred.
  • the functional group of the metal phthalocyanine derivative is selected from a —COOH group, a —SO 3 H group, or a salt thereof, and is preferably a —COOH group or a salt thereof in terms of deodorization and antibacterial properties.
  • Examples of the salt of the metal phthalocyanine derivative include a salt with an inorganic base and a salt with an organic base.
  • Preferable examples of the salt with an inorganic base include alkali metal salts such as sodium salt and potassium salt; alkaline earth metal salts such as calcium salt and magnesium salt; and copper (II) salt and ammonium salt.
  • Preferable examples of the salt with an organic base include salts with trimethylamine, triethylamine, pyridine, picoline, ethanolamine, diethanolamine, triethanolamine, dicyclohexylamine and the like.
  • the number of functional groups that is, the total of n1 to n4 is preferably 8 or less.
  • the number of functional groups is 8 or less, the deodorizing property and antibacterial property tend to be high.
  • the functional group is —COOH group
  • the number of functional groups is preferably 1 to 8
  • the functional group is —SO 3 H group
  • the number of functional groups is preferably 1 or 2.
  • the metal phthalocyanine derivative is attached to or mixed with the fiber.
  • the content of the metal phthalocyanine derivative with respect to the fiber is not particularly limited as long as the antibacterial effect can be exhibited.
  • the metal phthalocyanine derivative is preferably 0.1 to 10% by mass with respect to the fiber.
  • the content of the metal phthalocyanine derivative is more preferably 0.3 to 5% by mass, still more preferably 0.5 to 3% by mass.
  • the fiber is preferably cationized in advance.
  • the effect of supporting the metal phthalocyanine derivative is increased, the metal phthalocyanine derivative is kept in a high active state, and the residue that the metal phthalocyanine has not reacted has deodorant and antibacterial properties. Further effects can be enhanced.
  • Examples of the cationizing agent used in the cationization treatment include quaternary ammonium salt type chlorohydrin derivatives, quaternary ammonium salt type polymers, cationic polymers, cross-linked polyalkylimines, polyamine cationic resins, and glyoxal fiber fibers. Reaction type resin etc. are mentioned, These are used individually or in combination of 2 or more types. In particular, a quaternary ammonium salt type chlorohydrin derivative is preferable.
  • a method of supporting a metal phthalocyanine derivative on a fiber a method of applying a metal phthalocyanine derivative solution containing a binder component to a fiber or a fiber layer, applying by spraying or using a coater, a method of immersing the fiber or fiber layer in the solution, Alternatively, there are staining methods such as direct staining and ion staining.
  • the ion dyeing method is a dyeing method in which a cationic group is bonded to a fiber such as cotton or rayon, and the cationic group is ionically bonded to a carboxyl group or a sulfone anion group of the dye.
  • fiber materials carrying metal phthalocyanine derivatives include cellulosic fibers (cotton, hemp, rayon, pulp, etc.), protein fibers (wool, silk, etc.), polyamide fibers, polyester fibers, polyacrylic fibers, polyvinyl All natural fibers such as alcohol fibers, polyvinyl chloride fibers, polyvinylidene chloride fibers, polyolefin fibers and polyurethane fibers, recycled fibers, semi-synthetic fibers, and synthetic fibers are used.
  • cellulosic fibers particularly cotton or rayon, have good absorbency of exudate from wounds, and therefore have favorable conditions for expressing an enzyme-like function as a sucked carrier.
  • the cross-sectional shape of the fiber carrying the metal phthalocyanine derivative is not particularly limited, and may be any of circular, irregular, hollow and the like.
  • the fiber length of the said fiber is not specifically limited, either, A long fiber, a short fiber, a fine fiber, etc. may be sufficient. If it is a long fiber, it can be obtained by winding the fiber around a bobbin or the like after spinning. If it is a short fiber, it can be cut into a predetermined fiber length with a cutter or the like, or if it is a natural fiber, it can be used as it is.
  • the fineness of the fiber is not particularly limited, but it is preferably 0.3 to 3 dtex because it has high deodorizing properties and antibacterial properties and good absorbability of exudate.
  • the fiber layer contains a fiber carrying a metal phthalocyanine derivative and may be 100% by mass of the fiber, but may be mixed with other fibers within a range where the effects of the present invention can be obtained.
  • the fibers are preferably at least 50% by mass. More preferably, it is at least 75% by mass. Even more preferably, it is 85 mass% or more.
  • the other fibers to be mixed with the fiber carrying the metal phthalocyanine derivative in the fiber layer one or more of natural fibers, synthetic fibers, semi-synthetic fibers, regenerated fibers and the like can be used.
  • a heat-bonding fiber for example, a single-component or composite-component polyolefin fiber, polyester fiber, or polyamide fiber is used as the heat-adhesive fiber.
  • polypropylene / polyethylene, polyester / polyethylene, polyester / low-melting polyester are used.
  • the core-sheath type composite fiber is preferable.
  • the heat-adhesive fiber is preferably contained in an amount of 5 to 20% by mass with respect to the fiber layer. More preferably, it is 10 to 15% by mass.
  • the fiber layer preferably has a basis weight of 10 to 400 g / m 2 . More preferably, it is 15 to 100 g / m 2 , and still more preferably 20 to 50 g / m 2 . When the basis weight of the fiber layer is within the above range, sufficient antibacterial properties and absorption / retention of the leachate can be achieved.
  • the fiber layer contains at least a portion of the fiber carrying the metal phthalocyanine derivative, and can be used after being formed into yarn, woven or knitted fabric, nonwoven fabric, paper, or the like.
  • a knitted fabric or a nonwoven fabric is preferable because it can impart appropriate stretchability to the fiber layer itself.
  • the fiber web can be formed by a card method, an airlaid method, a wet papermaking method, a spunbond method, a melt blown method, a flash spinning method, an electrostatic spinning method, or the like.
  • the obtained fiber web is processed into a thermal bond nonwoven fabric such as an air-through nonwoven fabric or a thermocompression bonded nonwoven fabric, a chemical bond nonwoven fabric, a needle punched nonwoven fabric, a hydroentangled nonwoven fabric, a spunbond nonwoven fabric, or a melt blown nonwoven fabric.
  • hydroentangled nonwoven fabrics are preferable because they have good exudate absorbability (liquid absorbency and diffusibility) and can impart appropriate extensibility and stretchability.
  • the liquid absorber layer has a function of absorbing and retaining exudate from the wound.
  • a plurality of liquid absorber layers can be used in layers.
  • the liquid absorbent layer can have a basis weight, a thickness, and the like appropriately set according to the degree of the wound site of the covering material, the replacement time, and the like. For example, in the case of pressure ulcer patients with a large amount of exudate, the basis weight and thickness of the liquid absorber layer may be increased.
  • the basis weight of the liquid absorber layer is preferably 80 to 200 g / m 2 . More preferably, it is 50 to 120 g / m 2 .
  • the thickness of the liquid absorber layer is preferably 0.5 to 3 mm. More preferably, it is 0.8 to 1.2 mm.
  • the liquid absorbent layer preferably has, for example, a woven or knitted fabric, non-woven fabric, foam or the like, and in particular, a non-woven fabric is preferable because of its high absorbability of exudate and liquid absorption retention.
  • the material used for the nonwoven fabric is preferably a material having liquid absorbency, and for example, cellulosic fibers (cotton, hemp, rayon, pulp, etc.), protein fibers (wool, silk, etc.) are used. Among them, cotton or rayon is preferable because of its high liquid absorption.
  • the liquid absorber layer is laminated on the upper surface of the fiber layer and is simply laminated or joined to the fiber layer.
  • a bonding method with the fiber layer for example, a method of bonding by applying or impregnating a binder resin, a method of bonding by thermal bonding, a method of bonding by entanglement treatment, or the like is used.
  • the fiber web constituting the fiber layer and the fiber web constituting the liquid absorber layer are entangled and integrated by the hydroentanglement method or the needle punch method.
  • the fiber layer and the liquid absorber layer are entangled and integrated so that the exudate can easily move to the liquid absorber layer, and it exhibits the deodorizing and antibacterial functions of the fiber carrying the metal phthalocyanine derivative that constitutes the fiber layer. It becomes easy to do.
  • a chemical such as a deodorant or an antibacterial agent may be applied or impregnated in order to suppress the generation or odor of bacteria.
  • the wound dressing of the present invention has a form in which the above-described film layer, fiber layer, and liquid absorber layer are laminated.
  • the film layer has a desired function.
  • handleability such as sticking to a wound site is improved.
  • the wound dressing of the present invention is used by being stuck so that the film layer is in contact with the wound site, and fixed from above using a film or tape.
  • Example 1 Film layer having an opening As a film layer having an opening, a plastic net having a two-layer structure of polyester / polyethylene having a thickness of 0.11 mm and a basis weight of 12 g / m 2 (trade name “Sanki Co., Ltd. Delnet "product number X-550) was used. Other product numbers such as P-530 and X530N / W can be used.
  • Liquid Absorber Layer A hydroentangled nonwoven fabric (weight per 100 g / m 2 ) of 100% by mass of cotton was used.
  • Laminated body Binder resin was apply
  • Example 2 Film layer having apertures The same plastic net as in Example 1 was used.
  • the core component is polypropylene
  • the sheath component is a high-density polyethylene fineness of 2.2 dtex
  • the fiber length is 38 mm
  • a heat-adhesive core-sheath composite fiber (trade name NBF (H), Daiwabo Polytech) (Made by Co., Ltd.) was mixed and opened, and a fiber web having a basis weight of 40 g / m 2 was produced using a card machine.
  • Liquid absorber layer 100% by mass of rayon fiber (trade name Corona, manufactured by Daiwabo Rayon Co., Ltd.) having a fineness of 1.7 dtex and a fiber length of 38 mm is opened, and a fiber having a basis weight of 60 g / m 2 is obtained using a card machine. A web was made.
  • the film layer was laminated so that the polyethylene surface of the film layer was in contact with the fiber layer surface side of the fiber structure, subjected to heat bonding with a thermal laminator processor, and integrated to prepare the wound dressing of the present invention.
  • Example 2 The cotton cotton carrying iron (III) phthalocyanine octacarboxylic acid used in Example 2 was used as sample 1. Rayon cotton having a fineness of 1.7 dtex and a fiber length of 38 mm was used as a comparative sample. 1 g of each sample was placed in a 5 liter Tedlar bag, 3 liters of methyl mercaptan gas having a predetermined concentration (8.0 ppm) was injected, and the concentration was measured with a gas detector tube over time. The measurement results are shown in the table. The unit of concentration shown in the table is ppm.
  • Cotton cotton (Sample 1) carrying iron (III) phthalocyanine octacarboxylic acid shows high deodorizing performance against methyl mercaptan gas.
  • the wound dressing of the present invention can suppress and prevent the occurrence of infection wounds (gas gangrene) caused by mercaptan gas.
  • Example 2 Cut to a size of 10 cm ⁇ 10 cm and a medical gauze (Japanese Pharmacopoeia) as a comparative example were prepared.
  • the wound dressing of Example 2 was applied to the wound of a patient with groin pressure ulcer, and the four corners were fixed with paper tape.
  • the exchange period was once a day and the usage period was 2 weeks.
  • a comparative medical gauze was applied to the patient's wound and used for another two weeks.
  • Odor status VAS visual Using the analogue scale method (scoring scale method), the following scales were used for evaluation. The degree of “odor” before use was set to 10 levels (closer to 0), and the degree of odor was confirmed. 10 Unchanged 7 Slightly improved 5 Moderately improved 3 Significantly improved 1 Almost no odor 0 No odor at all
  • Example 2 has the above-mentioned odor evaluation of 3 (substantial improvement), and the pressure ulcer evaluation is A (the degree of improvement of the wound with the dressing of Example 2 compared to the comparative example) The effect of the present invention was confirmed.

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Abstract

L'invention concerne une matière de recouvrement de plaie qui protège une plaie de l'extérieur sans adhérer à la plaie et peut être aisément échangée sans faire souffrir le patient et qui sert à cicatriser la plaie. La matière de recouvrement de plaie comprend : une couche de film ayant des pores qui constitue la surface qui doit venir en contact avec une plaie ; une couche fibreuse qui comprend des fibres chargées par un dérivé de phtalocyanine métallique représenté par la Formule (I) (dans laquelle M représente un métal choisi parmi Fe, Co, Mn, Ti, V, Ni, Cu, Zn, Mo, W et Os ; R1, R2, R3 et R4 sont identiques ou différents et représentent chacun -COOH ou -SO3H ; et n1, n2, n3 et n4 sont des nombres positifs de 0-4 qui satisfont 1≤n1+n2+n3+n4≤8) et qui a été superposée sur la surface supérieure de la couche de film ; et une couche d'absorbeur de liquide superposée sur la surface supérieure de la couche fibreuse.
PCT/JP2011/057981 2011-03-30 2011-03-30 Matière de recouvrement de plaie WO2012131931A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
PCT/JP2011/057981 WO2012131931A1 (fr) 2011-03-30 2011-03-30 Matière de recouvrement de plaie
JP2013506938A JPWO2012131931A1 (ja) 2011-03-30 2011-03-30 創傷被覆材
CN201180069828.7A CN103501827B (zh) 2011-03-30 2011-03-30 创伤覆盖材料

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CN110448717B (zh) * 2019-08-14 2021-07-06 福建中润纸业有限公司 一种带有药理无纺布的吸液芯体的生产工艺

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