WO2012127794A1 - 窒素酸化物濃度測定装置 - Google Patents
窒素酸化物濃度測定装置 Download PDFInfo
- Publication number
- WO2012127794A1 WO2012127794A1 PCT/JP2012/001512 JP2012001512W WO2012127794A1 WO 2012127794 A1 WO2012127794 A1 WO 2012127794A1 JP 2012001512 W JP2012001512 W JP 2012001512W WO 2012127794 A1 WO2012127794 A1 WO 2012127794A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- voltage value
- flow path
- period
- light
- nitrogen oxide
- Prior art date
Links
- MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 title claims abstract description 133
- 238000005259 measurement Methods 0.000 title abstract description 19
- 239000007789 gas Substances 0.000 claims abstract description 43
- 238000001514 detection method Methods 0.000 claims description 68
- 238000000034 method Methods 0.000 claims description 18
- 230000008569 process Effects 0.000 claims description 11
- 150000004696 coordination complex Chemical class 0.000 claims description 9
- 150000004032 porphyrins Chemical class 0.000 claims description 9
- 230000001678 irradiating effect Effects 0.000 claims description 3
- 230000008859 change Effects 0.000 description 11
- 238000011144 upstream manufacturing Methods 0.000 description 10
- 239000000463 material Substances 0.000 description 9
- 229910017052 cobalt Inorganic materials 0.000 description 8
- 239000010941 cobalt Substances 0.000 description 8
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 7
- 238000010586 diagram Methods 0.000 description 6
- 239000004743 Polypropylene Substances 0.000 description 5
- 208000006673 asthma Diseases 0.000 description 5
- 238000007664 blowing Methods 0.000 description 5
- 230000007704 transition Effects 0.000 description 5
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 4
- 238000000862 absorption spectrum Methods 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 239000000758 substrate Substances 0.000 description 4
- 230000000903 blocking effect Effects 0.000 description 3
- 239000004745 nonwoven fabric Substances 0.000 description 3
- 150000004033 porphyrin derivatives Chemical class 0.000 description 3
- 125000001424 substituent group Chemical group 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 208000037883 airway inflammation Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 238000011088 calibration curve Methods 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 229920000728 polyester Polymers 0.000 description 2
- 229920000139 polyethylene terephthalate Polymers 0.000 description 2
- 239000005020 polyethylene terephthalate Substances 0.000 description 2
- -1 polypropylene Polymers 0.000 description 2
- 239000012286 potassium permanganate Substances 0.000 description 2
- JBRZTFJDHDCESZ-UHFFFAOYSA-N AsGa Chemical compound [As]#[Ga] JBRZTFJDHDCESZ-UHFFFAOYSA-N 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 229910001218 Gallium arsenide Inorganic materials 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 206010057190 Respiratory tract infections Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 125000003545 alkoxy group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 125000002947 alkylene group Chemical group 0.000 description 1
- 208000026935 allergic disease Diseases 0.000 description 1
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 125000003118 aryl group Chemical group 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007791 dehumidification Methods 0.000 description 1
- 238000003795 desorption Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 125000005843 halogen group Chemical group 0.000 description 1
- 125000001183 hydrocarbyl group Chemical group 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 125000001841 imino group Chemical group [H]N=* 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- HBMJWWWQQXIZIP-UHFFFAOYSA-N silicon carbide Chemical compound [Si+]#[C-] HBMJWWWQQXIZIP-UHFFFAOYSA-N 0.000 description 1
- 229910010271 silicon carbide Inorganic materials 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013076 target substance Substances 0.000 description 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/483—Physical analysis of biological material
- G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/314—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry with comparison of measurements at specific and non-specific wavelengths
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/0004—Gaseous mixtures, e.g. polluted air
- G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
- G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
- G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
- G01N33/0037—NOx
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N2021/3129—Determining multicomponents by multiwavelength light
- G01N2021/3137—Determining multicomponents by multiwavelength light with selection of wavelengths after the sample
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters
Definitions
- the present invention relates to a nitrogen oxide concentration measuring apparatus for measuring the concentration of nitrogen oxides such as nitric oxide.
- Nitric oxide (hereinafter referred to as “NO”) has been clarified as the physiological function of NO since it was discovered as the body of muscle relaxant factor. It is used as an index indicating the degree of infectious diseases.
- the measurement result of exhaled NO concentration is used as an index indicating the degree of respiratory tract infection caused by asthma and allergies that have been increasing in recent years.
- the NO gas concentration in exhaled breath is 2 ppb to 20 ppb in a normal person, but is known to increase about 3 times during airway inflammation such as asthma and allergy. Therefore, by measuring exhaled NO gas, it can be used as a treatment guideline for asthma such as determination of the degree of airway inflammation of a patient and determination of the dosage of an asthma drug.
- Patent Document 1 describes a method of measuring a nitrogen oxide concentration using a detection element containing a porphyrin that reacts with NO. Specifically, in the method described in Patent Document 1, the NO concentration is measured as follows. First, the voltage value output unit reflects light from the detection element in a first period in which the detection element is exposed to a gas not containing NO and in a second period in which the detection element is exposed to exhalation following the first period. A voltage value indicating a change in the amount of light is output. Next, the control unit obtains the first voltage value output during the first period and the second voltage value output during the second period, and subtracts the first voltage value from the second voltage value. As a result, the second voltage value is zero-point calibrated. Subsequently, the control unit calculates the concentration of NO contained in the expiration based on the second voltage value after the zero point calibration.
- Patent Document 1 does not particularly mention a method for generating a gas that does not contain NO supplied in the first period.
- a deNO process may be performed on the outside air taken in from the outside of the apparatus. It can be considered as a simple production method.
- such a method has a problem that the concentration of NO contained in exhalation cannot be accurately measured because the gas component after the deNO treatment may vary depending on the exhalation component at the time of measurement.
- the present invention has been made in view of the above-described problems, and an object of the present invention is to provide a nitrogen oxide concentration measuring apparatus that can accurately measure the concentration of NO contained in exhaled breath.
- the nitrogen oxide concentration measuring apparatus includes a detection element, a mouthpiece, a chamber, a gas flow path, a deNO unit, a light source, a voltage value output unit, and a control unit.
- the detection element contains a metal complex of porphyrin or a derivative thereof.
- the mouthpiece accepts exhalation.
- the chamber houses a detection element.
- the gas flow path communicates with the mouthpiece and the chamber.
- the NO removal unit is disposed in the gas flow channel, and the first period of the first period and the second period following the first period with respect to the exhaled air flowing in the gas flow path from the mouthpiece toward the chamber.
- the NO removal process is performed in The light source irradiates the detection element with light in the first period and the second period following the first period.
- the voltage value output unit outputs a voltage value indicating the amount of light having a predetermined wavelength among the light emitted from the detection element in the first and second periods.
- a control part acquires the density
- concentration measuring apparatus which can measure the density
- the block diagram which shows typically schematic structure of a nitrogen oxide concentration measuring apparatus.
- the block diagram which shows typically the internal structure of a nitrogen oxide concentration measuring apparatus.
- the functional block diagram which shows the structure of a control part.
- the graph which shows an example of the differential voltage value curve which shows transition of a differential voltage value.
- the graph which shows an example of a baseline.
- FIG. 1 is a block diagram schematically showing a schematic configuration of a nitrogen oxide concentration measuring apparatus 10 according to the embodiment.
- the nitrogen oxide concentration measuring device 10 is a device that measures the concentration of nitric oxide (hereinafter referred to as “NO”) contained in the breath of an asthmatic patient or the like (hereinafter referred to as “user”).
- the nitrogen oxide concentration measuring apparatus 10 includes a mouthpiece 11, a NO scrubber 12, a zero scrubber 13, a dryer 14, a chamber 15, a gas flow path 16, an upstream valve 17, a midstream valve 18, and a downstream valve 19.
- the mouthpiece 11 accepts the exhalation of the user.
- the user can place the mouthpiece 11 on the mouth and blow the breath into the nitrogen oxide concentration measuring apparatus 10.
- the NO scrubber 12 has a vent hole (not shown) for taking in outside air.
- the NO scrubber 12 incorporates a material having NO removal properties (for example, potassium permanganate or activated carbon).
- the NO scrubber 12 performs a de-NO process on the outside air flowing from the vent hole.
- de-NO means “NO removal”.
- the zero scrubber 13 (an example of a “de-NO unit”) is disposed downstream of the mouthpiece 11 in the gas flow path 16.
- the zero scrubber 13 incorporates a material having NO removal properties (for example, potassium permanganate or activated carbon).
- the zero scrubber 13 performs a NO removal process on the exhaled air flowing in from the mouthpiece 11. Specifically, the zero scrubber 13 performs deNO processing on exhaled breath in a first period described later, and does not perform de NO processing on exhaled breath in a second period described later. Further, the zero scrubber 13 performs a de-NO process on exhaled air in a third period to be described later.
- the dryer 14 is disposed upstream of the chamber 15 in the gas flow path 16.
- the dryer 14 contains a material having dehumidifying properties (for example, silica gel).
- the dryer 14 performs a dehumidification process on exhaled air (including exhaled exhaled air) flowing into the chamber 15.
- the chamber 15 is a housing for setting the detection element 30.
- the chamber 15 has a structure that allows outgoing light from an LED light source 21 (see FIG. 2), which will be described later, to pass through.
- the gas flow path 16 is connected to the mouthpiece 11 and the NO scrubber 12.
- the gas flow path 16 is connected to the mouthpiece 11 and the chamber 15.
- the gas flow path 16 is configured by, for example, a cylindrical air supply tube.
- the gas channel 16 includes a first channel 16a and a second channel 16b.
- the first flow path 16 a is formed between the mouthpiece 11 and the chamber 15.
- the first flow path 16 a accommodates the zero scrubber 13.
- the second channel 16b is formed between the mouthpiece 11 and the chamber 15, and is connected to both ends of the first channel 16a.
- the upstream valve 17 is a two-position switching type valve.
- the upstream valve 17 is disposed downstream of the mouthpiece 11 in the gas flow path 16.
- the upstream valve 17 switches the counterpart to which the mouthpiece 11 is connected in accordance with position switching control by a control unit 28 (see FIG. 2) described later.
- the upstream valve 17 closes the flow path toward the chamber 15 while the user is sucking outside air, and closes the flow path toward the NO scrubber 12 while the user is blowing exhalation.
- the middle flow valve 18 (an example of a “first flow path switching unit”) is a two-position switching valve.
- the middle flow valve 18 is disposed at a branch point A between the first flow path 16 a and the second flow path 16 b in the gas flow path 16.
- the middle flow valve 18 closes the first flow path 16a or the second flow path 16b in accordance with the position switching control by the control unit 28. Specifically, the middle flow valve 18 sequentially closes the second flow path 16b, the first flow path 16a, and the second flow path 16b when the user is blowing in exhaled air.
- the downstream valve 19 (an example of a “second flow path switching unit”) is a two-position switching type valve.
- the downstream valve 19 is disposed at the junction B of the first flow path 16 a and the second flow path 16 b in the gas flow path 16.
- the downstream valve 19 performs blocking of the second channel 16b, blocking of the first channel 16a, and blocking of the second channel 16b in the same manner as the midstream valve 18 according to the position switching control by the control unit 28. Do it sequentially.
- FIG. 2 is a block diagram schematically showing the internal configuration of the nitrogen oxide concentration measuring apparatus 10 according to the embodiment.
- the nitrogen oxide concentration measuring apparatus 10 includes an LED light source 21, a drive circuit 22, a lens 23, a dichroic mirror 24, a 415 nm light amount detection unit 25, a 435 nm light amount detection unit 26, a differential calculation processing unit 27, a control unit 28, and a storage unit. 29.
- the LED light source 21 (an example of a “light source unit”) irradiates the detection element 30 set in the chamber 15 with light under a predetermined condition.
- the configuration of the detection element 30 will be described later.
- the drive circuit 22 adjusts the amount of light applied to the detection element 30 by changing the current value supplied to the LED light source.
- the drive circuit 22 is configured to apply at least two types of currents at the time of initialization and at the time of measurement.
- the lens 23 and the dichroic mirror 24 are sequentially disposed between the chamber 15 and the 415 nm light amount detection unit 25 and the 435 nm light amount detection unit 26.
- the dichroic mirror 24 reflects light having a wavelength near 435 nm (hereinafter referred to as “435 nm light”) among transmitted light from the detection element 30 received through the lens 23 and transmits light having other wavelengths. .
- the 415 nm light quantity detection unit 25 is arranged on the path of the light transmitted through the dichroic mirror 24. As shown in FIG. 2, the 415 nm light quantity detection unit 25 includes a band pass filter 25a, a lens 25b, a photodiode 25c, and a current / voltage conversion circuit 25d.
- the bandpass filter 25a is an optical filter that transmits only light having a wavelength near 415 nm (hereinafter referred to as “415 nm light”). That is, the band pass filter 25a guides only 415 nm light from the light transmitted through the dichroic mirror 24 to the lens 25b.
- the lens 25b guides the 415 nm light transmitted through the bandpass filter 25a to the photodiode 25c.
- the photodiode 25c outputs a current corresponding to the light amount of 415 nm light that has passed through the lens 25b (hereinafter referred to as “415 nm light amount”).
- the current / voltage conversion circuit 25d converts the current value output from the photodiode 25c into a voltage value and outputs the voltage value to the differential arithmetic processing unit 27.
- the 415 nm light amount detection unit 25 outputs the voltage value V 415 related to the 415 nm light amount.
- the 435 nm light quantity detection unit 26 is arranged on the path of 435 nm light reflected by the dichroic mirror 24. As shown in FIG. 2, the 435 nm light quantity detection unit 25 includes a band pass filter 26a, a lens 26b, a photodiode 26c, and a current / voltage conversion circuit 26d.
- the band pass filter 26a transmits only 435 nm light.
- the lens 26b guides the light transmitted through the band pass filter 26a to the photodiode 26c.
- the photodiode 26c outputs a current corresponding to the amount of light of 435 nm light transmitted through the lens 26b (hereinafter referred to as “435 nm light amount”).
- the current / voltage conversion circuit 26 d converts the current value output from the photodiode 26 c into a voltage value and outputs the voltage value to the differential arithmetic processing unit 27.
- the 435 nm light amount detection unit 26 outputs the voltage value V 435 related to the 435 nm light amount.
- the differential calculation processing unit 27 calculates the difference between the 415 nm light amount and the 435 nm light amount based on the voltage value V 415 output from the 415 nm light amount detection unit 25 and the voltage value V 435 output from the 435 nm light amount detection unit 26.
- the differential voltage value Vd shown is output. In the present embodiment, the differential voltage value Vd is obtained by subtracting the voltage value V435 from the voltage value V415 .
- the 415 nm light amount detection unit 25, the 435 nm light amount detection unit 26, and the differential calculation processing unit 27 have a voltage value related to the light amount of a predetermined wavelength (including a 415 nm wavelength and a 435 nm wavelength).
- a “voltage value output unit” for output is configured.
- the control unit 28 acquires the NO concentration based on the differential voltage value Vd output from the differential calculation processing unit 27. Further, the control unit 28 performs position switching control of the upstream valve 17, the midstream valve 18, and the downstream valve 19. In addition, the control unit 28 instructs the drive circuit 22 to supply the initialization current and the measurement current. The configuration and function of the control unit 28 will be described later.
- the storage unit 29 stores a conversion formula that defines a calibration curve that is used to acquire the NO concentration based on the differential voltage value Vd output from the differential calculation processing unit 27.
- the detection element 30 includes a base material and a metal complex of porphyrin or a derivative thereof supported on the base material (hereinafter sometimes simply referred to as “metal complex”).
- the substrate may be a work cloth, a nonwoven fabric, a porous body, or the like.
- the substrate may be formed of cellulose; glass fiber; polymer such as polyester or polypropylene. Examples of polyester include PET (polyethylene terephthalate).
- the porphyrin is preferably in the base material. For example, porphyrin may be soaked in the base material or kneaded.
- the porphyrin derivative includes a substance in which an arbitrary substituent is bonded to the porphyrin skeleton.
- substituent include a hydrocarbon group such as an alkyl group, an alkylene group, and an aryl group which may be branched; an alkoxy group such as a methoxy group and an ethoxy group; a halogen group; a hydroxy group; an amino group; an imino group; A carbonyl group etc. are mentioned.
- the detection element 30 includes a nonwoven fabric and a metal complex that has been dripped into the nonwoven fabric.
- the detection element 30 includes a CoT (dtBu) PP shown in FIG. 3 as a metal complex, that is, a Co complex of a porphyrin derivative having a tertiary butyl group (t-Bu) located at the 3.5 position of the phenyl group. .
- CoT (dtBu) PP has an absorption peak in the vicinity of 415 nm to 420 nm when the valence of cobalt is 2 (Co (II)).
- the valence of cobalt changes from divalent to trivalent (Co (III)) by exposure to NO.
- Co (III) has an absorption peak in the vicinity of 435 nm to 440 nm.
- the NO concentration can be measured by comparing the amount of transmitted light with a predetermined wavelength from the detection element 30 before exposure to the gas to be detected with the amount of transmitted light with a predetermined wavelength from the detection element after exposure. .
- the difference between the 415 nm light amount and the 435 nm light amount is acquired before and after the detection element is exposed to the gas to be detected, and the NO concentration is acquired based on the voltage value of the difference and the conversion formula.
- the wavelength of light used for detection can be changed according to the configuration of the porphyrin or its derivative (the type of substituent) and the metal element.
- the nitrogen oxide concentration measuring apparatus 10 initializes the detection element (hereinafter referred to as “initialization”) by irradiating the detection element 30 with light stronger than that at the time of concentration detection by the LED light source 21. ) Initialization means that the detection element is not exposed to the detection target substance.
- the central metal of the complex is cobalt, and as described above, the NO concentration is measured based on the change of the valence of cobalt from divalent to trivalent.
- FIG. 5 is a functional block diagram illustrating the configuration of the control unit 28 according to the embodiment.
- the control unit 28 includes a valve control unit 100, a drive circuit control unit 110, a differential voltage value acquisition unit 120, a baseline acquisition unit 130, a zero point calibration unit 140, and an NO concentration acquisition unit 150. .
- the valve control unit 100 performs the position switching control described above. Specifically, the valve control unit 100 closes the flow path toward the chamber 15 by the upstream valve 17 while the user is inhaling outside air, and flows toward the NO scrubber 12 while the user is blowing in exhalation. The path is blocked by the upstream valve 17. Thus, after the outside air that has been subjected to the NO removal process by the NO scrubber 12 is inhaled by the user, the exhaled air that the user blows is sent to the chamber 15.
- the valve control unit 100 performs the initial predetermined period (for example, about 5 seconds, hereinafter referred to as “first period”) by the midstream valve 18 and the downstream valve 19.
- the second channel 16b is closed.
- the valve control unit 100 closes the first flow path 16a by the midstream valve 18 and the downstream valve 19 during a predetermined period (for example, about 5 seconds, hereinafter referred to as “second period”) following the first period.
- the valve control unit 100 closes the second flow path 16b by the midstream valve 18 and the downstream valve 19 during a predetermined period (for example, about 5 seconds, hereinafter referred to as “third period”) following the second period.
- exhaled air that has been subjected to de-NO treatment by the zero scrubber 13 is sent to the chamber 15 during the first period
- exhaled gas that has not been de-NO treated during the second period is sent to the chamber 15, and exhaled by the zero scrubber 13 during the third period
- the NO-treated exhaled air is sent to the chamber 15 again.
- the detection element 30 is exposed to the exhaled breath that has been subjected to the deNO treatment during the first period, the exhalation itself during the second period, and the exhaled breath that has been subjected to the de NO treatment during the third period.
- the drive circuit control unit 110 instructs the drive circuit 22 to supply the initialization current and the measurement current. Specifically, the drive circuit control unit 110 instructs the drive circuit 22 to supply an initialization current when the detection element 30 is set in the chamber 15. In addition, the drive circuit control unit 110 instructs the drive circuit 22 to supply the measurement current when the user is blowing exhalation. The drive circuit control unit 110 instructs the drive circuit 22 to stop the measurement current at the end of the third period.
- the differential voltage value acquisition unit 120 acquires the differential voltage value Vd output from the differential calculation processing unit 27 in real time.
- FIG. 6 is a graph showing an example of the differential voltage value curve VC showing the transition of the differential voltage value Vd.
- the differential voltage value curve VC corresponds to the first differential voltage value curve VC1 corresponding to the first period (time t0 to time t1) and the second period (time t1 to time t2).
- the second differential voltage value curve VC2 and the third differential voltage value curve VC3 corresponding to the third period (time t2 to time t3).
- the differential voltage value curve VC is a set of differential voltage values Vd output from the differential voltage value acquisition unit 120 in real time.
- the second differential voltage value curve VC2 gradually decreases with the passage of measurement time, and the second differential voltage value curve VC2 is not stable.
- the first differential voltage value curve VC1 and the third differential voltage value curve VC3 also decrease as the measurement time elapses.
- the baseline acquisition unit 130 acquires a baseline BL for zero-point calibration of the differential voltage value curve VC based on the first differential voltage value curve VC1 and the third differential voltage value curve VC3.
- FIG. 7 is a graph showing an example of the baseline BL.
- the baseline BL is interpolated based on the first differential voltage value V t1 at the end time t1 of the first period and the third differential voltage value V t3 at the end time t3 of the third period.
- the base line BL is a straight line connecting the coordinate p (first differential voltage value V t1 , time t1) and the coordinate q (third differential voltage value V t3 , time t3).
- the zero point calibration unit 140 calibrates the differential voltage value curve VC based on the baseline BL. As a result, the zero points of a plurality of differential voltage values (hereinafter referred to as “a plurality of second differential voltage values V t2 ”) included in the second differential voltage value curve VC2 are matched. Such zero-point calibration of a plurality of second differential voltage value V t2, the fourth differential voltage curve VC4 including a plurality of fourth differential voltage value is produced.
- the NO concentration acquisition unit 150 acquires the concentration of NO contained in exhaled breath according to the fourth differential voltage value curve VC4 generated by the zero point calibration unit 140. Specifically, the NO concentration acquisition unit 150 acquires the transition of the NO concentration by converting the fourth differential voltage value curve VC using a conversion equation indicating a calibration curve. The NO concentration acquisition unit 150 acquires an average value of a period during which the transition of the NO concentration is stable as the concentration of NO contained in exhaled breath.
- the nitrogen oxide concentration measuring apparatus 10 includes a zero scrubber 13 disposed in the gas flow path 16.
- the zero scrubber 13 performs a deNO process on the exhaled gas flowing from the mouthpiece 11 toward the chamber 15 in the gas flow path 16 in the first period and the second period.
- the control unit 28 acquires the concentration of NO contained in exhalation based on the differential voltage value Vd output in the second period with the differential voltage value Vd output in the first period as a reference.
- the control unit 28 zero point calibration is performed using the exhaled breath subjected to the NO removal process by the zero scrubber 13. Therefore, since it is possible to suppress the fluctuation of the gas component after the de-NO treatment compared to the case where the zero-point calibration gas is generated by performing the de-NO treatment on the outside air, the concentration of NO contained in the exhalation Can be measured with high accuracy. Moreover, since it is not necessary to arrange a compressor or the like for taking in outside air, the configuration of the nitrogen oxide concentration measuring apparatus 10 can be simplified.
- the middle flow valve 18 (an example of the “first flow path switching unit”) disposed at the branch point between the first flow path 16a and the second flow path 16b in the gas flow path 16 is The two flow paths are closed and the first flow path is closed in the second period.
- the exhaled exhaled air and the exhaled air that has not been deNOed can flow alternately into the chamber 15. Therefore, it is not necessary to provide a storage room for temporarily storing exhaled air separately from the chamber 15. As a result, the configuration of the nitrogen oxide concentration measuring apparatus 10 can be simplified.
- the nitrogen oxide concentration measuring apparatus 10 includes a downstream valve 19 (of the “second flow path switching unit”) arranged at the junction of the first flow path 16a and the second flow path 16b in the gas flow path 16. An example).
- the downstream valve 19 closes the second flow path in the first period and closes the first flow path in the second period.
- the control unit 28 uses the first differential voltage value curve VC1 acquired during the first period and the third difference acquired during the third period. Based on the dynamic voltage value curve VC3, the second differential voltage value curve VC2 acquired during the second period is zero-point calibrated. The control unit 28 acquires the concentration of NO contained in exhaled breath according to the fourth voltage value generated by the zero point calibration.
- the inventors diligently studied the cause of the second differential voltage value curve VC2 changing ("decreasing" in the present embodiment) with the passage of measurement time.
- the first differential voltage value curve VC1 and the third differential voltage value curve VC3 vary with the measurement time (see FIG. 6), and this variation has a tendency to be different for each measurement time. Obtained knowledge. This is because a slight change occurs in the desorption equilibrium between the cobalt in the detection element 30 and the oxygen in the breath due to the irradiation light at the time of measurement. Therefore, if the second differential voltage value curve VC2 is zero-calibrated based only on the first differential voltage value curve VC1, the measurement result of the NO concentration may vary.
- the second differential voltage value curve VC2 is based on the base line BL acquired according to the first differential voltage value curve VC1 and the third differential voltage value curve VC3. Is zero-calibrated. That is, by interpolating the baseline BL corresponding to the change of the zero point, the differential voltage value curve VC can be calibrated with high accuracy, so that the measurement accuracy of the NO concentration can be improved.
- the control unit 28 acquires the first differential voltage value V t1 at the end time t1 of the first period and the third differential voltage value V t3 at the end time t3 of the third period. .
- the control unit 28 acquires the baseline BL based on the first differential voltage value V t1 and the third differential voltage value V t3 .
- the first differential voltage value V t1 is the voltage value at the end time t1 closest to the second period
- the third differential voltage value V t3 is the most differential voltage value Vd after the second period. This is the voltage value when stabilizing. Therefore, since the baseline BL can be accurately handled with respect to the change of the zero point, the measurement accuracy of the NO concentration can be further improved.
- the differential calculation processing unit 27 outputs a voltage value indicating a difference between the 415 nm light amount and the 435 nm light amount. Therefore, compared with the case where only one of the 415 nm light amount and the 435 nm light amount is detected, a smaller change in the light amount can be detected, so that the NO concentration detection sensitivity can be improved.
- the control unit 28 acquires the differential voltage value Vd from the differential arithmetic processing unit 27 in real time.
- the control unit 28 may acquire only a part of the differential voltage values Vd out of the differential voltage values Vd output from the differential calculation processing unit 27.
- the control unit 28 based on the two differential voltage values Vd acquired at the predetermined time in the first period and the predetermined time in the third period, one differential voltage value Vd acquired at the predetermined time in the second period. May be zero-point calibrated. That is, the control unit 28 may not have to acquire the differential voltage value curve VC.
- the control unit 28 is based on the first differential voltage value V t1 at the end time t1 of the first period and the third differential voltage value V t3 at the end time t3 of the third period.
- the baseline BL is acquired, the present invention is not limited to this.
- the control unit 28 may acquire an average value of all the plurality of differential voltage values in the first period, instead of the first differential voltage value V t1 .
- the control unit 28 may acquire an average value of all the plurality of differential voltage values in the third period instead of the third differential voltage value V t3 .
- control unit 28 obtains the baseline BL based on a plurality of differential voltage values in the first period and the third period, not based on typical differential voltage values in the first period and the third period. can do.
- control unit 28 can obtain an approximate line or an approximate curve obtained from a plurality of differential voltage values in the first period and the third period as the base line BL by the least square method.
- the base material of the detection element transmits light.
- the base material of the detection element may be configured to reflect light, and the nitrogen oxide concentration measuring device obtains various signals by detecting the reflected light amount instead of the transmitted light amount from the detection element. It may be configured as follows. In this case, a substrate that reflects light, such as alumina, silicon, silicon carbide, gallium arsenide, ceramic, plastic, or metal, can be used as the sensor substrate. Therefore, the 415 nm light amount detection unit 25 and the 435 nm light amount detection unit 26 only need to be able to detect light emitted from the detection element.
- the concentration of NO was measured based on both 415 nm light and 435 nm light.
- the nitrogen oxide concentration measuring apparatus 10 may measure the concentration of NO based only on a change in the amount of light having a single wavelength.
- the initialization is performed by irradiating the detection element 30 with light.
- the initialization may be performed by applying heat to the detection element 30.
- the baseline BL is set linearly, but may be set curvedly.
- the nitrogen oxide concentration measuring device 10 displays a flow rate measuring device for measuring the flow rate of exhaled breath, a thermometer for detecting temperature, or the measured concentration of NO.
- a display monitor or the like may be provided.
- the baseline acquisition unit 130 performs zero-point calibration of the differential voltage value curve VC based on the first differential voltage value curve VC1 and the third differential voltage value curve VC3.
- the baseline acquisition unit 130 may acquire the baseline BL based only on the first differential voltage value curve VC1.
- the drive circuit controller 110 is in the second period.
- the drive circuit 22 may be instructed to stop the measurement current at the end time t2.
- zero point calibration can be performed using exhaled breath that has been subjected to de-NO treatment, so that the concentration of NO contained in exhaled breath can be accurately measured.
- the setting method of the baseline BL can be selected as appropriate, and an approximate straight line or an approximate curve obtained from a plurality of differential voltage values Vd in the first period by the least square method may be used as the baseline BL.
- the average value of the plurality of differential voltage values Vd in the first period may be used as the baseline BL.
- the nitrogen oxide concentration measuring apparatus of the present invention can accurately measure the concentration of NO contained in exhaled breath, it can be widely applied to sensors that measure the concentration of nitrogen oxides.
- DESCRIPTION OF SYMBOLS 10 Nitrogen oxide density
- concentration measuring apparatus 11 Mouthpiece 12 ; NO scrubber 13 ... Zero scrubber (an example of "de-NO part")
- DESCRIPTION OF SYMBOLS 14 ... Dryer 15 ... Chamber 16 ... Gas flow path 16a ... 1st flow path 16b ... 2nd flow path 17 ... Upstream valve 18 ... Middle flow valve (an example of "1st flow path switching part”) 19: Downstream valve (an example of “second flow path switching unit”) 21 ... LED light source (an example of a “light source”) DESCRIPTION OF SYMBOLS 22 ... Drive circuit 23 ... Lens 24 ... Dichroic mirror 25 ... 415nm light quantity detection part 26 ...
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Spectroscopy & Molecular Physics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Combustion & Propulsion (AREA)
- Urology & Nephrology (AREA)
- Physiology (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
特に、呼気中のNO濃度の測定結果を、近年増え続ける喘息やアレルギーによる気道感染の程度を示す指標として用いることで、患者に負担をかけない非侵襲での疾病の診断が可能になるとして注目されている。呼気中のNOガス濃度は、正常人では2ppb~20ppbであるが、喘息やアレルギーなどの気道炎症時には約3倍に増大することが知られている。そのため、呼気NOガスを測定することで、患者の気道炎症の程度の判定や、喘息治療薬の投薬量の決定など喘息の治療指針に利用できる。
ここで、特許文献1では、第1期間に供給されるNOを含有しない気体の生成方法について特に触れられていないが、例えば、装置の外部から取り込まれる外気に対して脱NO処理を施すことが簡便な生成方法として考えられる。しかしながら、このような手法では、測定時の呼気成分によって脱NO処理後の気体成分が変動するおそれがあるため、呼気に含まれるNOの濃度を精度良く測定することができないという問題がある。
本発明は、上述の問題に鑑みてなされたものであり、呼気に含まれるNOの濃度を精度良く測定可能な窒素酸化物濃度測定装置を提供することを目的とする。
第1の態様に係る窒素酸化物濃度測定装置は、検出エレメントと、マウスピースと、チャンバと、気体流路と、脱NO部と、光源と、電圧値出力部と、制御部と、を備える。検出エレメントは、ポルフィリン又はその誘導体の金属錯体を含有する。マウスピースは、呼気を受け入れる。チャンバは、検出エレメントを収容する。気体流路は、マウスピースとチャンバとに連通する。脱NO部は、気体流路内に配置されており、マウスピースからチャンバに向かって気体流路内を流れる呼気に対して、第1期間及び第1期間に続く第2期間のうち第1期間において脱NO処理を施す。光源は、第1期間及び第1期間に続く第2期間において、検出エレメントに光を照射する。電圧値出力部は、第1及び第2期間において、検出エレメントから出射される光のうち所定波長を有する光の量を示す電圧値を出力する。制御部は、電圧値出力部から出力される電圧値に基づいて、呼気に含まれるNOの濃度を取得する。
本発明によれば、呼気に含まれるNOの濃度を精度良く測定可能な窒素酸化物濃度測定装置を提供することができる。
実施形態に係る窒素酸化物濃度測定装置10の概略構成について、図面を参照しながら説明する。図1は、実施形態に係る窒素酸化物濃度測定装置10の概略構成を模式的に示すブロック図である。
NOスクラバ12は、外気を取り込むための図示しない通気孔を有する。NOスクラバ12は、脱NO性を有する材料(例えば、過マンガン酸カリウムや活性炭など)を内蔵する。NOスクラバ12は、通気孔から流入する外気に脱NO処理を施す。なお、本実施形態において、“脱NO”とは、“NOの除去”を意味する。
気体流路16は、マウスピース11とNOスクラバ12とに繋がる。また、気体流路16は、マウスピース11とチャンバ15とに繋がる。気体流路16は、例えば筒状の送気管によって構成される。気体流路16は、第1流路16aと第2流路16bとを含む。第1流路16aは、マウスピース11とチャンバ15との間に形成される。第1流路16aは、ゼロスクラバ13を収容する。第2流路16bは、マウスピース11とチャンバ15との間に形成され、第1流路16aの両端に繋がっている。
実施形態に係る窒素酸化物濃度測定装置10がNO濃度を測定するための内部構成について、図面を参照しながら説明する。図2は、実施形態に係る窒素酸化物濃度測定装置10の内部構成を模式的に示すブロック図である。
記憶部29は、差動演算処理部27から出力される差動電圧値Vdに基づいてNO濃度を取得するため用いられる検量線を規定する変換式などを記憶する。
検出エレメント30は、基材と、基材に担持された、ポルフィリン又はその誘導体の金属錯体(以下、単に「金属錯体」と称することがある)とを備える。
基材は、職布、不織布、多孔体等であってもよい。基材は、セルロース;ガラス繊維;ポリエステル、ポリプロピレン等のポリマー等で形成されていてもよい。ポリエステルとして、例えばPET(ポリエチレンテレフタレート)が挙げられる。ポルフィリンは、基材中に入り込んでいることが好ましい。例えば、ポルフィリンは基材中に染み込んでいてもよいし、練りこまれていてもよい。
ポルフィリンの誘導体は、ポルフィリン骨格に任意の置換基が結合した物質を包含する。置換基としては、分岐してもよいアルキル基、アルキレン基、及びアリール基等の炭化水素基;メトキシ基及びエトキシ基等のアルコキシ基;ハロゲン基;ヒドロキシ基;アミノ基;イミノ基;ニトロ基;カルボニル基等が挙げられる。
本実施形態において、検出エレメント30は、不織布と、滴下されることによって不織布に染み込んだ金属錯体とを備える。また、検出エレメント30は、金属錯体として、図3に示すCoT(dtBu)PP、すなわちフェニル基の3.5位に位置するターシャリーブチル基(t-Bu)を有するポルフィリン誘導体のCo錯体を備える。
本実施形態では、後述するように、415nm光量と435nm光量の差分を検出エレメントの被検出ガス暴露の前後で取得し、さらにその差分の電圧値と変換式とに基づいてNO濃度を取得する。
また、本実施形態において、窒素酸化物濃度測定装置10は、LED光源21によって濃度検出時よりも強い光を検出エレメント30に照射することによって、検出エレメントを初期化(以下、「イニシャライズ」という。)する。初期化とは、検出エレメントを検出対象物質に暴露していない状態とすることである。本実施形態では、錯体の中心金属はコバルトであり、上述したように、コバルトの価数の二価から三価への変化に基づいてNO濃度が測定される。しかし、被検出ガスに暴露しなくても、検出エレメント30が大気中のO2又はCOと反応することでコバルトはCo(II)からCo(III)に変化する。このような変化は、検出精度を低下させる。よって、被検出ガスに暴露する前に、イニシャライズによって、コバルトがCo(II)に還元される。
実施形態に係る制御部28の構成について、図面を参照しながら説明する。図5は、実施形態に係る制御部28の構成を示す機能ブロック図である。以下、制御部28の構成を機能とともに説明する。
制御部28は、バルブ制御部100と、駆動回路制御部110と、差動電圧値取得部120と、ベースライン取得部130と、ゼロ点校正部140と、NO濃度取得部150と、を備える。
(1)実施形態に係る窒素酸化物濃度測定装置10は、気体流路16内に配置されたゼロスクラバ13を備える。ゼロスクラバ13は、マウスピース11からチャンバ15に向かって気体流路16内を流れる呼気に対して、第1期間及び第2期間のうち第1期間において脱NO処理を施す。制御部28は、第1期間に出力される差動電圧値Vdを基準とする第2期間に出力される差動電圧値Vdに基づいて、呼気に含まれるNOの濃度を取得する。
また、外気を取り込むためのコンプレッサなどを配置する必要がないため、窒素酸化物濃度測定装置10の構成を簡素化することができる。
以上、本発明の一実施形態について説明したが、本発明は上記実施形態に限定されるものではなく、発明の要旨を逸脱しない範囲で種々の変更が可能である。
例えば、制御部28は、第1差動電圧値Vt1に代えて、第1期間の複数の差動電圧値すべての平均値を取得してもよい。同様に、制御部28は、第3差動電圧値Vt3に代えて、第3期間の複数の差動電圧値すべての平均値を取得してもよい。
11…マウスピース
12…NOスクラバ
13…ゼロスクラバ(「脱NO部」の一例)
14…ドライヤ
15…チャンバ
16…気体流路
16a…第1流路
16b…第2流路
17…上流バルブ
18…中流バルブ(「第1流路切換え部」の一例)
19…下流バルブ(「第2流路切換え部」の一例)
21…LED光源(「光源部」の一例)
22…駆動回路
23…レンズ
24…ダイクロイックミラー
25…415nm光量検出部
26…435nm光量検出部
27…差動演算処理部
28…制御部
29…記憶部
30…検出エレメント
100…バルブ制御部
110…駆動回路制御部
120…差動電圧値取得部
130…ベースライン取得部
140…ゼロ点校正部
150…NO濃度取得部
Claims (7)
- ポルフィリン又はその誘導体の金属錯体を含有する検出エレメントと、
呼気を受け入れるマウスピースと、
前記検出エレメントを収容するチャンバと、
前記マウスピースと前記チャンバとに連通する気体流路と、
前記気体流路内に配置されており、前記マウスピースから前記チャンバに向かって前記気体流路内を流れる呼気に対して、前記第1期間及び前記第1期間に続く第2期間のうち第1期間において脱NO処理を施す脱NO部と、
前記第1及び第2期間において、前記検出エレメントに光を照射する光源と、
前記第1及び第2期間において、前記検出エレメントから出射される光のうち所定波長を有する光の量を示す電圧値を出力する電圧値出力部と、
前記第1期間に前記電圧値出力部から出力される電圧値を基準とする前記第2期間に前記電圧値出力部から出力される電圧値に基づいて、前記呼気に含まれるNOの濃度を取得する制御部と、
を備える窒素酸化物濃度測定装置。 - 前記気体流路は、前記脱NO部を収容する第1流路と、前記第1流路の両端に繋がる第2流路と、前記第1流路と前記第2流路との分岐点に配置される第1流路切換え部と、を有し、
前記第1流路切換え部は、前記第1期間において前記第2流路を閉じ、前記第2期間において前記第1流路を閉じる、
請求項2に記載の窒素酸化物濃度測定装置。 - 前記気体流路は、前記第1流路と前記第2流路との合流点に配置される第2流路切換え部を有し、
前記第2流路切換え部は、前記第1期間において前記第2流路を閉じ、前記第2期間において前記第1流路を閉じる、
請求項2に記載の窒素酸化物濃度測定装置。 - 前記脱NO部は、前記第2期間に続く第3期間において、呼気に前記脱NO処理を施し、
前記電圧値出力部は、前記第1及び第2期間に続く前記第3期間において、前記検出エレメントから出射される光のうち所定波長を有する光の量を示す電圧値を出力し、
前記制御部は、前記第1、第2及び第3期間において前記電圧値出力部から出力される第1、第2及び第3電圧値を取得し、前記第1及び第3電圧値に基づいて前記第2電圧値を校正することによって生成される第4電圧値に応じて、前記呼気に含まれるNOの濃度を取得する、
請求項1に記載の窒素酸化物濃度測定装置。 - 前記制御部は、前記第1期間の終了時に前記電圧値出力部から出力される電圧値を前記第1電圧値として取得し、前記第3期間の終了時に前記電圧値出力部から出力される電圧値を前記第3電圧値として取得する、
請求項4に記載の窒素酸化物濃度測定装置。 - 前記制御部は、前記第1期間中に前記電圧値出力部から出力される複数の電圧値の平均値を前記第1電圧値として取得し、前記第3期間中に前記電圧値出力部から出力される複数の電圧値の平均値を前記第3電圧値として取得する、
請求項4に記載の窒素酸化物濃度測定装置。 - 前記所定波長は、第1波長と、前記第1波長と異なる第2波長とを含み、
前記電圧値出力部は、前記第1波長を有する光の量と、前記第2波長を有する光の光との差分を示す電圧値を出力する、
請求項4に記載の窒素酸化物濃度測定装置。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013505794A JPWO2012127794A1 (ja) | 2011-03-18 | 2012-03-05 | 窒素酸化物濃度測定装置 |
EP12761266.1A EP2687836A1 (en) | 2011-03-18 | 2012-03-05 | Nitrogen oxide concentration measurement device |
US14/004,542 US20130345588A1 (en) | 2011-03-18 | 2012-03-05 | Nitrogen oxide concentration measurement device |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2011-060414 | 2011-03-18 | ||
JP2011060414 | 2011-03-18 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2012127794A1 true WO2012127794A1 (ja) | 2012-09-27 |
Family
ID=46878974
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2012/001512 WO2012127794A1 (ja) | 2011-03-18 | 2012-03-05 | 窒素酸化物濃度測定装置 |
Country Status (4)
Country | Link |
---|---|
US (1) | US20130345588A1 (ja) |
EP (1) | EP2687836A1 (ja) |
JP (1) | JPWO2012127794A1 (ja) |
WO (1) | WO2012127794A1 (ja) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014188720A1 (ja) * | 2013-05-23 | 2014-11-27 | パナソニックヘルスケア株式会社 | 呼気測定装置及びその制御方法 |
JP2020103437A (ja) * | 2018-12-26 | 2020-07-09 | 日本特殊陶業株式会社 | 呼気ガス検知装置 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2013190411A2 (en) * | 2012-06-19 | 2013-12-27 | Empire Technology Development Llc | Recyclable and reusable oxygen scavenger |
US20180348155A1 (en) * | 2017-06-02 | 2018-12-06 | Ngk Spark Plug Co., Ltd. | Gas detection apparatus |
Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07294396A (ja) * | 1994-04-27 | 1995-11-10 | Shimadzu Corp | ガス分析計 |
JP2000019107A (ja) * | 1998-07-06 | 2000-01-21 | Zexel Corp | 紫外線吸収式のオゾン濃度測定方法及び装置 |
JP2004226097A (ja) * | 2003-01-20 | 2004-08-12 | Horiba Ltd | 吸光分析計およびこれを用いた測定装置 |
JP2008539416A (ja) * | 2005-04-26 | 2008-11-13 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 窒素含有ガス化合物検出用の低コスト機器 |
WO2010061536A1 (ja) | 2008-11-26 | 2010-06-03 | パナソニック株式会社 | 窒素酸化物検出エレメント、窒素酸化物検出センサとこれを使用した窒素酸化物濃度測定装置および窒素酸化物濃度測定方法 |
-
2012
- 2012-03-05 EP EP12761266.1A patent/EP2687836A1/en not_active Withdrawn
- 2012-03-05 JP JP2013505794A patent/JPWO2012127794A1/ja active Pending
- 2012-03-05 WO PCT/JP2012/001512 patent/WO2012127794A1/ja active Application Filing
- 2012-03-05 US US14/004,542 patent/US20130345588A1/en not_active Abandoned
Patent Citations (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH07294396A (ja) * | 1994-04-27 | 1995-11-10 | Shimadzu Corp | ガス分析計 |
JP2000019107A (ja) * | 1998-07-06 | 2000-01-21 | Zexel Corp | 紫外線吸収式のオゾン濃度測定方法及び装置 |
JP2004226097A (ja) * | 2003-01-20 | 2004-08-12 | Horiba Ltd | 吸光分析計およびこれを用いた測定装置 |
JP2008539416A (ja) * | 2005-04-26 | 2008-11-13 | コーニンクレッカ フィリップス エレクトロニクス エヌ ヴィ | 窒素含有ガス化合物検出用の低コスト機器 |
WO2010061536A1 (ja) | 2008-11-26 | 2010-06-03 | パナソニック株式会社 | 窒素酸化物検出エレメント、窒素酸化物検出センサとこれを使用した窒素酸化物濃度測定装置および窒素酸化物濃度測定方法 |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014188720A1 (ja) * | 2013-05-23 | 2014-11-27 | パナソニックヘルスケア株式会社 | 呼気測定装置及びその制御方法 |
EP3000393A4 (en) * | 2013-05-23 | 2016-07-13 | Panasonic Healthcare Holdings Co Ltd | BREATHER MEASURING DEVICE AND CONTROL METHOD THEREFOR |
JPWO2014188720A1 (ja) * | 2013-05-23 | 2017-02-23 | パナソニックヘルスケアホールディングス株式会社 | 呼気測定装置及びその制御方法 |
US9931058B2 (en) | 2013-05-23 | 2018-04-03 | Panasonic Healthcare Holdings Co., Ltd. | Exhalation measurement device and control method therefor |
JP2020103437A (ja) * | 2018-12-26 | 2020-07-09 | 日本特殊陶業株式会社 | 呼気ガス検知装置 |
JP7189011B2 (ja) | 2018-12-26 | 2022-12-13 | 日本特殊陶業株式会社 | 呼気ガス検知装置 |
Also Published As
Publication number | Publication date |
---|---|
JPWO2012127794A1 (ja) | 2014-07-24 |
EP2687836A1 (en) | 2014-01-22 |
US20130345588A1 (en) | 2013-12-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN111801576B (zh) | 具有压力传感器和热气敏传感器的传感器装置 | |
JP6023075B2 (ja) | 呼吸アルコール濃度を測定するための方法及び装置 | |
JP5491598B2 (ja) | 分析中の呼気の流れ制御 | |
US6955650B2 (en) | Metabolic calorimeter employing respiratory gas analysis | |
WO2010094967A1 (en) | Apparatus and method for breath testing | |
JP5632611B2 (ja) | 信号品質決定及び信号補正システム及び作動方法 | |
KR101547798B1 (ko) | 호흡 알코올 농도 측정 장치 및 측정 방법 | |
WO2012124269A1 (ja) | 窒素酸化物濃度測定装置 | |
US11674900B2 (en) | NDIR sensor, sampling method and system for breath analysis | |
US20030065274A1 (en) | Method of respiratory gas analysis using a metabolic calorimeter | |
WO2012127794A1 (ja) | 窒素酸化物濃度測定装置 | |
JP2020530908A5 (ja) | ||
US9986935B2 (en) | On-airway pulmonary function tester | |
US20110077544A1 (en) | Method for optimizing the gas conversion rate in a respiratory gas analyzer | |
US20200093399A1 (en) | Breath analyzer device | |
JP2017509394A (ja) | 自己校正する血液チャンバ | |
ES2383240T3 (es) | Método para la linealización de señal de la señal de salida de un sensor de gas | |
JPWO2018174182A1 (ja) | 呼気測定装置 | |
US20100327167A1 (en) | Spectroscopic gas sensor and method for ascertaining an alcohol concentration in a supplied air volume, in particular an exhaled volume | |
TWI473994B (zh) | 感測裝置 | |
Kim et al. | Development of non-invasive optical transcutaneous pCO/sub 2/gas sensor and analytic equipment |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 12761266 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 14004542 Country of ref document: US Ref document number: 2012761266 Country of ref document: EP |
|
ENP | Entry into the national phase |
Ref document number: 2013505794 Country of ref document: JP Kind code of ref document: A |
|
NENP | Non-entry into the national phase |
Ref country code: DE |