WO2012091278A3 - 나노에멀젼 형태의 안과용 조성물 - Google Patents

나노에멀젼 형태의 안과용 조성물 Download PDF

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Publication number
WO2012091278A3
WO2012091278A3 PCT/KR2011/008359 KR2011008359W WO2012091278A3 WO 2012091278 A3 WO2012091278 A3 WO 2012091278A3 KR 2011008359 W KR2011008359 W KR 2011008359W WO 2012091278 A3 WO2012091278 A3 WO 2012091278A3
Authority
WO
WIPO (PCT)
Prior art keywords
ophthalmic composition
nanoemulsion
present
composition
type ophthalmic
Prior art date
Application number
PCT/KR2011/008359
Other languages
English (en)
French (fr)
Other versions
WO2012091278A2 (ko
Inventor
이성일
양재식
이근혁
최병선
류종현
Original Assignee
한림제약(주)
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 한림제약(주) filed Critical 한림제약(주)
Priority to EP11853373.6A priority Critical patent/EP2659903B1/en
Priority to CN201180063169.6A priority patent/CN103282044B/zh
Publication of WO2012091278A2 publication Critical patent/WO2012091278A2/ko
Publication of WO2012091278A3 publication Critical patent/WO2012091278A3/ko

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A61K38/13—Cyclosporins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Inorganic Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

본 발명은 활성성분으로서 사이클로스포린 A과 함께 특정 오일 및 계면활성제를 수성 매질 중에서 자가유화방법으로 나노에멀젼 형태로 설계한 안과용 조성물을 제공한다. 본 발명에 따른 안과용 조성물은 0.22 ㎛ 필터를 사용한 제균여과가 가능하므로, 제조비용을 낮출 수 있고 또한 생산현장에서 쉽게 적용할 수 있다. 또한, 본 발명의 조성물은 첨가제들의 사용을 최소화하면서, 우수한 안정성을 가진다.
PCT/KR2011/008359 2010-12-28 2011-11-04 나노에멀젼 형태의 안과용 조성물 WO2012091278A2 (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP11853373.6A EP2659903B1 (en) 2010-12-28 2011-11-04 Nanoemulsion-type ophthalmic composition
CN201180063169.6A CN103282044B (zh) 2010-12-28 2011-11-04 纳米乳剂形态的眼科用组合物

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0136667 2010-12-28
KR20100136667 2010-12-28

Publications (2)

Publication Number Publication Date
WO2012091278A2 WO2012091278A2 (ko) 2012-07-05
WO2012091278A3 true WO2012091278A3 (ko) 2012-08-23

Family

ID=46383598

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/008359 WO2012091278A2 (ko) 2010-12-28 2011-11-04 나노에멀젼 형태의 안과용 조성물

Country Status (4)

Country Link
EP (1) EP2659903B1 (ko)
KR (2) KR20120075446A (ko)
CN (1) CN103282044B (ko)
WO (1) WO2012091278A2 (ko)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101492447B1 (ko) * 2013-05-20 2015-02-23 주식회사태준제약 사이클로스포린을 함유하는 나노에멀젼 점안 조성물 및 그의 제조 방법
KR101736342B1 (ko) 2014-08-29 2017-05-16 (주)진토닌케이유 인삼추출물을 유효성분으로 하는 안과질환 치료용 조성물
KR101682439B1 (ko) * 2015-02-27 2016-12-05 연세대학교 산학협력단 Bigh3 단백질을 포함하는 점액 분비 증가용 약학조성물
JOP20170147B1 (ar) 2016-07-07 2021-08-17 Salvat Lab Sa تركيبة عينية تشتمل على زيت الخروع ودهون ثلاثية متوسطة السلسلة
CN109010270B (zh) * 2018-09-03 2021-07-30 辅必成（上海）医药科技有限公司 一种阳离子材料制备的眼用乳
CN114245737A (zh) 2019-06-11 2022-03-25 司斐股份有限公司 微乳剂组合物
CN110237233B (zh) * 2019-07-30 2021-01-15 沈阳兴齐眼药股份有限公司 一种含有环孢素的眼用药物组合物、其制备方法及用途
IL294896A (en) * 2022-07-20 2024-02-01 LYOTROPIC DELIVERY SYSTEMS Ltd Topical administration of cyclosporine to the eye

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20020016290A1 (en) * 1996-03-25 2002-02-07 Floc'h Robert Cyclosporin a formulations as nanoparticles
KR100368181B1 (ko) * 1994-05-17 2003-04-10 알러간, 인코포레이티드 시각조직에의국부도포를위한누선특효유제
KR100669510B1 (ko) * 2005-08-17 2007-01-16 보람제약주식회사 사이크로스포린을 함유한 나노 에멀젼 농축액 조성물 및 그제조방법
KR20080007580A (ko) * 2005-04-12 2008-01-22 엘란 파마 인터내셔널 리미티드 사이클로스포린을 함유하는 나노입자형 조절 방출 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050059583A1 (en) * 2003-09-15 2005-03-17 Allergan, Inc. Methods of providing therapeutic effects using cyclosporin components
US10137083B2 (en) * 2006-03-07 2018-11-27 SGN Nanopharma Inc Ophthalmic preparations
US20100303915A1 (en) * 2009-06-02 2010-12-02 Abbott Medical Optics Inc. Therapeutic opthalmic emulsions

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100368181B1 (ko) * 1994-05-17 2003-04-10 알러간, 인코포레이티드 시각조직에의국부도포를위한누선특효유제
US20020016290A1 (en) * 1996-03-25 2002-02-07 Floc'h Robert Cyclosporin a formulations as nanoparticles
KR20080007580A (ko) * 2005-04-12 2008-01-22 엘란 파마 인터내셔널 리미티드 사이클로스포린을 함유하는 나노입자형 조절 방출 조성물
KR100669510B1 (ko) * 2005-08-17 2007-01-16 보람제약주식회사 사이크로스포린을 함유한 나노 에멀젼 농축액 조성물 및 그제조방법

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2659903A4 *

Also Published As

Publication number Publication date
EP2659903B1 (en) 2016-09-14
WO2012091278A2 (ko) 2012-07-05
KR20120075445A (ko) 2012-07-06
EP2659903A2 (en) 2013-11-06
KR20120075446A (ko) 2012-07-06
KR101182115B1 (ko) 2012-09-12
EP2659903A4 (en) 2014-06-18
CN103282044B (zh) 2016-07-06
CN103282044A (zh) 2013-09-04

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