WO2012068140A1 - Nanoparticle isoflavone compositions & methods of making and using the same - Google Patents

Nanoparticle isoflavone compositions & methods of making and using the same Download PDF

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Publication number
WO2012068140A1
WO2012068140A1 PCT/US2011/060829 US2011060829W WO2012068140A1 WO 2012068140 A1 WO2012068140 A1 WO 2012068140A1 US 2011060829 W US2011060829 W US 2011060829W WO 2012068140 A1 WO2012068140 A1 WO 2012068140A1
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WO
WIPO (PCT)
Prior art keywords
genistein
formulation
subject
nanoparticulate
therapeutically effective
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US2011/060829
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English (en)
French (fr)
Inventor
Edmund Joseph Elder
Mark Joseph Sacchetti
Randall Joseph Tlachac
John L. Zenk
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Humanetics Corp
Original Assignee
Humanetics Corp
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Filing date
Publication date
Application filed by Humanetics Corp filed Critical Humanetics Corp
Priority to JP2013538998A priority Critical patent/JP2013545752A/ja
Priority to CA2852410A priority patent/CA2852410C/en
Priority to EP11840762.6A priority patent/EP2640188B1/en
Publication of WO2012068140A1 publication Critical patent/WO2012068140A1/en
Anticipated expiration legal-status Critical
Priority to IL226377A priority patent/IL226377B/en
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
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    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
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    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P35/00—Antineoplastic agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
    • A61P5/16—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4 for decreasing, blocking or antagonising the activity of the thyroid hormones
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y15/00—Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery

Definitions

  • genistein is formulated for parenteral administration (e.g., via intravenous injection or infusion, intravascular injection, subcutaneous injection, or intramuscular injection), it is often the case that relatively large volumes of drug formulation must be delivered in order to achieve and maintain therapeutic blood plasma concentrations.
  • Suspension formulations prepared as described herein are suited to providing high concentration genistein formulations (i.e., formulations containing genistein in amounts of about 250 mg/mL or greater). Though genistein exhibits low to virtually no solubility in several pharmaceutically acceptable solvents, the nanoparticulate suspension formulations described herein can incorporate genistein up to and over 300 mg/ml. In specific embodiments, genistein formulations as described herein may incorporate genistein in amounts ranging from about 250 mg/mL to about 500 mg/mL.

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nanotechnology (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Dermatology (AREA)
  • Dispersion Chemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Inorganic Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Oncology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
PCT/US2011/060829 2010-11-15 2011-11-15 Nanoparticle isoflavone compositions & methods of making and using the same Ceased WO2012068140A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2013538998A JP2013545752A (ja) 2010-11-15 2011-11-15 ナノ粒子イソフラボン組成物、ならびにそれを製造および使用する方法
CA2852410A CA2852410C (en) 2010-11-15 2011-11-15 Nanoparticle isoflavone compositions & methods of making and using the same
EP11840762.6A EP2640188B1 (en) 2010-11-15 2011-11-15 Nanoparticle isoflavone compositions & methods of making and using the same
IL226377A IL226377B (en) 2010-11-15 2013-05-16 Nanoparticle isoflavone compositions & methods of making and using the same

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/946,711 2010-11-15
US12/946,711 US8900635B2 (en) 2010-11-15 2010-11-15 Nanoparticle isoflavone compositions and methods of making and using the same

Publications (1)

Publication Number Publication Date
WO2012068140A1 true WO2012068140A1 (en) 2012-05-24

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PCT/US2011/060829 Ceased WO2012068140A1 (en) 2010-11-15 2011-11-15 Nanoparticle isoflavone compositions & methods of making and using the same

Country Status (6)

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US (9) US8900635B2 (enExample)
EP (1) EP2640188B1 (enExample)
JP (3) JP2013545752A (enExample)
CA (1) CA2852410C (enExample)
IL (1) IL226377B (enExample)
WO (1) WO2012068140A1 (enExample)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8551530B2 (en) 2010-11-15 2013-10-08 Humanetics Corporation Nanoparticle isoflavone compositions and methods of making and using the same
EP2786751A1 (en) * 2013-04-04 2014-10-08 Humanetics Corporation Genistein for use in the method of mitigating detrimental effects of exposure to ionizing radiation
US9084726B2 (en) 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same
US9623004B2 (en) 2013-08-02 2017-04-18 Humanetics Corporation Administration of a therapeutic amount of genistein to mitigate erectile dysfunction resulting from radiation therapy for prostate cancer only throughout a defined administration period commencing shortly before and concluding after radiation therapy
WO2023212130A1 (en) 2022-04-28 2023-11-02 GreenStone Biosciences, Inc. Treatment of the adverse cardiovascular effects of cannabinoids
WO2025117337A1 (en) 2023-11-28 2025-06-05 GreenStone Biosciences, Inc. Genistein phosphate derivatives

Families Citing this family (17)

* Cited by examiner, † Cited by third party
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US20140274966A1 (en) * 2013-03-14 2014-09-18 Hygia Pharmaceuticals, Llc Drink Product Containing Genistein and Use Thereof
US20150126597A1 (en) * 2013-11-07 2015-05-07 Humanetics Corporation Genistein cancer treatment regimen maximizing cancer radiation therapy benefits
US20170000761A1 (en) * 2013-11-27 2017-01-05 Humanetics Corporation Protecting tissue and mitigating injury from chemical exposure
TWI583404B (zh) * 2015-07-13 2017-05-21 高雄醫學大學 ７,３’,４’-大豆異黃酮製劑的製備方法
WO2018156946A1 (en) * 2017-02-24 2018-08-30 Humanetics Corporation Protecting tissue and mitigating injury from radiation-induced ionizing events
WO2018168777A1 (ja) * 2017-03-13 2018-09-20 学校法人関西学院 嚢胞性線維症予防又は治療剤
US11129894B2 (en) * 2017-09-29 2021-09-28 - Humanetics Corporation Sensitizing cells to proton radiation
JP2019099557A (ja) * 2017-11-28 2019-06-24 日本化薬株式会社 ベンダムスチンを含有する溶液製剤
US10881634B2 (en) * 2017-12-07 2021-01-05 Hughes Biotechnology Co., Ltd Method for treatment or prevention of a disease associated with a decrease in bone mass and method of improving bone architecture and bio mechanical strength of bone
US20220193103A1 (en) * 2019-04-23 2022-06-23 The University Of North Carolina At Chapel Hill Nano-puerarin regulates tumor microenvironment and facilitates chemo- and immunotherapy in murine triple negative breast cancer model
WO2021207176A1 (en) * 2020-04-06 2021-10-14 Humanetics Corporation Genistein treatment of inflammatory pulmonary injury
CA3195195A1 (en) * 2020-10-16 2022-05-27 Humanetics Corporation Solid dispersion genistein compositions and methods of making and using the same
US20240058299A1 (en) * 2021-01-11 2024-02-22 Humanetics Corporation Genistein treatment of inflammatory and immunological disorders
CN112843048A (zh) * 2021-04-01 2021-05-28 郑州新泽生物科技有限公司 一种用于抑制雄性动物发情的液体制剂及其制备方法
CN113080365B (zh) * 2021-04-02 2022-12-06 嘉应学院 一种大豆素纳米粉的制备方法及其应用
WO2023177676A1 (en) * 2022-03-14 2023-09-21 University Of South Florida Genistein for asthma treatment
CN114948869A (zh) * 2022-05-26 2022-08-30 中国药科大学 一种染料木素纳米混悬液的制备方法及该方法制备的染料木素纳米混悬液

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020197A1 (en) * 2004-07-01 2007-01-25 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
US20070116510A1 (en) * 2005-11-18 2007-05-24 Kelly Francis J Turnbuckle lock
US20090035336A1 (en) * 2005-06-29 2009-02-05 Dsm Ip Assets B.V. Isoflavone nanoparticles and use thereof

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4390559A (en) 1979-04-11 1983-06-28 Z-L Limited Partnership Isoflavones and related compounds, methods of preparing and using and antioxidant compositions containing same
US5302401A (en) * 1992-12-09 1994-04-12 Sterling Winthrop Inc. Method to reduce particle size growth during lyophilization
JP2001309764A (ja) 2000-05-01 2001-11-06 Taiyo Kagaku Co Ltd ポリフェノール類組成物
US7655694B2 (en) 2000-06-14 2010-02-02 The United States Of America As Represented By The Department Of Health And Human Services Phytoestrogenic isoflavone compositions, their preparation and use thereof for protection against and treatment of radiation injury
US6976647B2 (en) 2001-06-05 2005-12-20 Elan Pharma International, Limited System and method for milling materials
ES2254725T3 (es) 2002-06-29 2006-06-16 Aquanova German Solubilisate Technologies (Agt) Gmbh Concentrados de isoflavonas y metodos para su preparacion.
AU2003298659A1 (en) 2002-11-15 2004-06-15 Cargill, Incorporated Soluble isoflavone compositions
WO2005033279A2 (en) 2003-09-29 2005-04-14 University Of Virginia Patent Foundation Discovery of novel soluble crystalline anesthetics
EP1802279A1 (en) 2004-09-29 2007-07-04 Michael Ary Bos Caratenoid composition and method for preparation thereof
UA89513C2 (uk) 2004-12-03 2010-02-10 Элан Фарма Интернешнл Лтд. Стабільна композиція з наночастинок ралоксифену гідрохлориду
TWI372749B (en) 2005-03-10 2012-09-21 Theravance Inc Crystalline forms of a biphenyl compound
EA015336B1 (ru) 2005-06-03 2011-06-30 Элан Фарма Интернэшнл Лтд. Стабильная композиция с наночастицами ацетаминофена
US8685456B2 (en) * 2005-06-29 2014-04-01 Dsm Ip Assets B.V. Topical compositions comprising nanoparticles of an isoflavone
US9743680B2 (en) 2005-10-14 2017-08-29 Wild Flavors, Inc. Microemulsions for use in food and beverage products
CA2631492A1 (en) * 2005-12-15 2007-06-21 Acusphere, Inc. Processes for making particle-based pharmaceutical formulations for oral administration
WO2008086400A2 (en) * 2007-01-09 2008-07-17 Isp Investments Inc. Sirtuin-activating compounds of enhanced bioavailability
JP2009067752A (ja) 2007-09-14 2009-04-02 Akuto Kk 製剤の製造方法及び製剤
EP2349237A4 (en) 2008-07-31 2012-07-25 Santosh Kumar Kar CURCUMIN NANOTEILS AND MANUFACTURING METHOD THEREFOR
WO2011091065A2 (en) 2010-01-19 2011-07-28 Northwestern University Synthetic nanostructures including nucleic acids and/or other entities
AU2011265184B2 (en) 2010-06-11 2016-08-04 Sloan-Kettering Institute For Cancer Research Multivalent glycopeptide constructs and uses thereof
US8900635B2 (en) 2010-11-15 2014-12-02 Humanetics Corporation Nanoparticle isoflavone compositions and methods of making and using the same
JP5948871B2 (ja) 2011-12-28 2016-07-06 株式会社東洋新薬 ポリフェノール含有組成物
US9084726B2 (en) 2013-11-26 2015-07-21 Humanetics Corporation Suspension compositions of physiologically active phenolic compounds and methods of making and using the same

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020197A1 (en) * 2004-07-01 2007-01-25 Warner-Lambert Company Llc Preparation of pharmaceutical compositions containing nanoparticles
US20090035336A1 (en) * 2005-06-29 2009-02-05 Dsm Ip Assets B.V. Isoflavone nanoparticles and use thereof
US20070116510A1 (en) * 2005-11-18 2007-05-24 Kelly Francis J Turnbuckle lock

Non-Patent Citations (21)

* Cited by examiner, † Cited by third party
Title
"Remington's Pharmaceutical Sciences", 1985, MAACK PUBLISHING CO.
ATKINSON ET AL., AM J CLIN NUTR., vol. 79, no. 2, February 2004 (2004-02-01), pages 326 - 33
BHATHENA, S. J.M. T. VELASQUEZ, AM J CLIN NUTR., vol. 76, no. 6, December 2002 (2002-12-01), pages 1191 - 201
CLIFTON-BLIGH ET AL., MENOPAUSE, vol. 8, no. 4, August 2011 (2011-08-01), pages 259 - 65
COTTER A.K. D. CASHMAN, NUTR REV., vol. 61, no. 10, October 2003 (2003-10-01), pages 346 - 51
GOODMAN-GRUEN, D.D. KRITZ-SILVERSTEIN, MENOPAUSE, vol. 10, no. 5, September 2003 (2003-09-01), pages 427 - 32
MAGEE P. J.I. R. ROLAND, BR J NUTR., vol. 91, no. 4, April 2004 (2004-04-01), pages 513 - 31
MESSINA, M. J., NUTR RE., vol. 61, no. 4, April 2003 (2003-04-01), pages 117 - 31
MOHAMMAD ET AL., MOL CANCER THER., vol. 2, no. 12, December 2003 (2003-12-01), pages 1361 - 8
MORABITO ET AL., J BONE MINER RES., vol. 17, no. 10, October 2002 (2002-10-01), pages 1904 - 12
NICOSIA ET AL., HEMATOL ONCOL CLIN NORTH AM., vol. 17, no. 4, August 2003 (2003-08-01), pages 927 - 43
PARK, O. J.Y. J. SURH, TOXICOL LETT., vol. 150, no. 1, 15 April 2004 (2004-04-15), pages 43 - 56
ROOMANS, G. M., AM J RESPIR MED., vol. 2, no. 5, 2003, pages 413 - 31
SAKAR, F. H.Y. LI, CANCER INVEST, vol. 21, no. 5, 2003, pages 744 - 57
See also references of EP2640188A4
SETCHELL K. D.E. LYDEKING-OLSEN, AM J CLIN NUTR., vol. 78, no. 3, September 2003 (2003-09-01), pages 593S - 609S
SUN ET AL., NUTR CANCER., vol. 39, no. 1, 2001, pages 85 - 95
TAKIMOTO ET AL., CANCER EPIDEMIOL BIOMARKERS PREV., vol. 12, no. 11, November 2003 (2003-11-01), pages 1213 - 21
URBAN ET AL., J UROL., vol. 165, no. 1, January 2001 (2001-01-01), pages 294 - 300
WEI ET AL.: "2003 Nov", J NUTR., vol. 133, no. 11, pages 3811 S - 3819S
YOUNG, S. G.S. PARTHASARATHY, WEST J MED., vol. 160, no. 2, February 1994 (1994-02-01), pages 153 - 54

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US20210000788A1 (en) 2021-01-07
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