WO2012030973A2 - Procédés et systèmes permettant de produire des données image de rayonnement visible et de radiographie - Google Patents

Procédés et systèmes permettant de produire des données image de rayonnement visible et de radiographie Download PDF

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Publication number
WO2012030973A2
WO2012030973A2 PCT/US2011/049987 US2011049987W WO2012030973A2 WO 2012030973 A2 WO2012030973 A2 WO 2012030973A2 US 2011049987 W US2011049987 W US 2011049987W WO 2012030973 A2 WO2012030973 A2 WO 2012030973A2
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WIPO (PCT)
Prior art keywords
ray
imaging system
image
detector
camera
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Application number
PCT/US2011/049987
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English (en)
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WO2012030973A3 (fr
Inventor
Gary R. Sims
Michael B. Nelson
Michael D. Cable
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Spectral Instruments Imaging, LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Spectral Instruments Imaging, LLC filed Critical Spectral Instruments Imaging, LLC
Priority to EP11822569.7A priority Critical patent/EP2612134B1/fr
Publication of WO2012030973A2 publication Critical patent/WO2012030973A2/fr
Publication of WO2012030973A3 publication Critical patent/WO2012030973A3/fr

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/02—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material
    • G01N23/04—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material
    • G01N23/046—Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by transmitting the radiation through the material and forming images of the material using tomography, e.g. computed tomography [CT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0033—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room
    • A61B5/0035—Features or image-related aspects of imaging apparatus classified in A61B5/00, e.g. for MRI, optical tomography or impedance tomography apparatus; arrangements of imaging apparatus in a room adapted for acquisition of images from more than one imaging mode, e.g. combining MRI and optical tomography
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0059—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence
    • A61B5/0071—Measuring for diagnostic purposes; Identification of persons using light, e.g. diagnosis by transillumination, diascopy, fluorescence by measuring fluorescence emission
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/44—Constructional features of apparatus for radiation diagnosis
    • A61B6/4417—Constructional features of apparatus for radiation diagnosis related to combined acquisition of different diagnostic modalities
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/50—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications
    • A61B6/508—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment specially adapted for specific body parts; specially adapted for specific clinical applications for non-human patients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B6/00—Apparatus or devices for radiation diagnosis; Apparatus or devices for radiation diagnosis combined with radiation therapy equipment
    • A61B6/52—Devices using data or image processing specially adapted for radiation diagnosis
    • A61B6/5211—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data
    • A61B6/5229—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image
    • A61B6/5247—Devices using data or image processing specially adapted for radiation diagnosis involving processing of medical diagnostic data combining image data of a patient, e.g. combining a functional image with an anatomical image combining images from an ionising-radiation diagnostic technique and a non-ionising radiation diagnostic technique, e.g. X-ray and ultrasound
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/645—Specially adapted constructive features of fluorimeters
    • G01N21/6456—Spatial resolved fluorescence measurements; Imaging
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2223/00—Investigating materials by wave or particle radiation
    • G01N2223/40—Imaging
    • G01N2223/419—Imaging computed tomograph

Definitions

  • the present invention relates to x-ray imaging systems in general and more particularly to systems for producing both visible light and x-ray images in molecular imaging applications.
  • Imaging systems are well-known in the art and are used to capture various types or modes of images from any of a wide variety of objects or specimens.
  • Common image types or modes that may be captured by such a device include visible light images, wherein visible light reflected by the object or specimen is captured by a camera associated with the imaging system.
  • the visible light comprises light that is emitted by the object itself, as opposed to light that is reflected by the object.
  • the emitted light may be generated by a luminescence process, a fluorescence process, or by a combination thereof.
  • x-ray image may then be used to correlate or compare certain features and attributes of the object with the visual light image of the same object.
  • combination or composite images i.e., comprising a visible light image as well as an x-ray image
  • the object being imaged is an animal, although the ability to capture such composite images may be desirable in other applications as well.
  • An imaging system may include a main enclosure having at least one access door that defines a substantially light-tight imaging compartment when the access door is in a closed position.
  • An object platform provided within the main enclosure holds an object to be imaged.
  • a camera system positioned on a first side of the object platform is operable to capture a visible light image of the object.
  • a radiation detector positioned on the first side of the object platform is moveable from a first position to a second position across a field of view of the camera system. The radiation detector is operable to capture a radiographic image of the object by moving the radiation detector from the first position to the second position while detecting radiation from the object.
  • an imaging system includes a main enclosure having at least one access door that defines a substantially light-tight imaging compartment when the access door is in a closed position.
  • An object platform provided within the main enclosure holds an object to be imaged.
  • a camera system positioned on a first side of the object platform is operable to capture a visible light image of the object.
  • An x-ray source positioned on a second side of the object platform is operable to direct x-rays toward the second side of the object platform.
  • An x-ray detector positioned on the first side of the object platform is moveable across a field of view of the camera system from a first position to a second position.
  • the x-ray detector is operable to capture an x-ray image of the object by moving the x-ray detector from the first position to the second position while operating the x-ray source to direct x- rays toward the second side of the object platform, x-rays from the x-ray source passing through the object platform and the object positioned on the object platform before being incident on the x-ray detector.
  • Also disclosed is a method for producing visible light and x-ray images of an object that includes the steps of: Positioning an object to be imaged on an object platform; using a camera located on a first side of the object platform to capture a visible light image of the object; directing x-rays toward a second side of the object platform from an x-ray source located on the second side of the object platform; detecting x-rays passing through the object with an x-ray detector located on the first side of the object platform; and moving the x-ray detector across a field of view of the camera while continuing to direct x-rays toward the second side of the object platform in order to capture a two-dimensional x-ray image of the object.
  • Figure 1 is a perspective view of one embodiment of a composite imaging system according to the teachings of the present invention.
  • Figure 2 is a sectional view in perspective of the composite imaging system illustrated in Figure 1 more clearly showing certain components associated with the visible light and x-ray imaging systems;
  • Figure 3 is a sectional view in perspective of the composite imaging system of Figure 1 more clearly showing the x-ray detector and gantry assembly;
  • Figure 4a is a composite image of mammalian specimens comprising reflected and emitted light images
  • Figure 4b is a composite image of the mammalian specimens of Figure 4a, but comprising emitted light and radiographic images;
  • Figure 5 is an enlarged perspective view of the x-ray detector and gantry assembly
  • Figure 6 is a bottom view of the x-ray detector and gantry assembly illustrated in Figure 5 with the shield plate removed to more clearly show the gantry assembly;
  • Figure 7 is a side view of the x-ray detector and gantry assembly illustrated in Figure 5.
  • a composite imaging system 10 i.e., an imaging system that is operable to capture both visible light and radiographic images of an object
  • Figures 1-3 One embodiment of a composite imaging system 10 (i.e., an imaging system that is operable to capture both visible light and radiographic images of an object) is best seen in Figures 1-3 and is shown and described herein as it may be used in a molecular imaging application to capture various types of images of various kinds of objects or specimens 12.
  • the composite imaging system 10 may be used to capture and display various types of composite images 14, 16 of mammalian specimens, as shown Figures 4a and 4b.
  • the composite image 14 depicted in Figure 4a comprises superimposed reflected and emitted light images of the mammalian specimens 12
  • the composite image 16 depicted in Figure 4b comprises superimposed emitted light and radiographic (e.g., x-ray) images of the mammalian specimens 12.
  • the composite imaging system 10 may be used to capture other types of images from other kinds of specimens 12, as will be described in further detail herein.
  • the composite imaging system 10 may comprise a generally rectangularly-shaped housing 18 that defines an imaging compartment 20 therein.
  • the housing 18 of imaging system 10 may be provided with an access door 22 that can be moved vertically between a closed position (shown in Figure 1) and an opened position (not specifically illustrated in the drawing figures) to allow the user to access the imaging compartment or chamber 20 defined within housing 18.
  • the imaging compartment 20 may be provided with an imaging platform or stage 24 therein that is configured to hold one or more objects or specimens 12 to be studied and imaged.
  • Imaging system 10 may also be provided with a camera system 26 and lighting system 28. Lighting system 28 may be provided with a plurality of individual light sources 30 ( Figure 3) that can be selectively illuminated. As will be described in further detail below, camera system 26 and lighting system 28 may be used together to capture various types of visible light images of the specimen or specimens 12.
  • Composite imaging system 10 may also be provided with a radiographic or x-ray imaging system 32 that may be used to capture various types of radiographic images, including x-ray images, of the object or specimen 12.
  • x-ray imaging system 32 may comprise a radiation or x-ray detector assembly 34 as well as an x-ray source 36.
  • the x-ray detector assembly 24 and x-ray source 36 are provided on opposite sides of the imaging platform or stage 24, as best seen in Figure 2.
  • the x-ray detector assembly 34 is moveably mounted to a gantry assembly 38 that allows the x-ray detector assembly 34 to be moved along longitudinal direction (indicated by arrows 40) between a first position (shown in Figure 1) and a second position (not specifically illustrated in the drawing figures) on the opposite side of gantry assembly 38.
  • a first position shown in Figure 1
  • a second position not specifically illustrated in the drawing figures
  • movement of the x-ray detector assembly 34 in the longitudinal direction 40 allows two-dimensional radiographic images to be acquired of the object or specimen 12.
  • the composite imaging system 10 is designed or configured to be connected to separate computer system 42, e.g., via a suitable data link 44.
  • the computer system 42 may comprise a conventional "PC" type of computer system and may be provided with a display system 46, along with one or more input devices, such as a keyboard 48 and a suitable pointing device, such as a mouse 50.
  • the computer system 42 allows a user to operate the composite imaging system 10 and view on display system 46 images produced by the imaging system 10.
  • the composite imaging system 10 may be used to capture any of a wide range of visible light images and radiographic images of the object or specimen 12 positioned on the imaging platform or stage 24.
  • visible light refers to light that is commonly regarded as being in the visible light spectrum (i.e., having wavelengths ranging from about 400 nanometers (nm) to about 700 nm).
  • visible light may also refer to light in the near-infrared and near-ultraviolet ranges as well, i.e., light having wavelengths longer than 700 nm and shorter than 400 nm, respectively.
  • visible light image refers to light images produced by detecting light in the visible light range (i.e., in the near infrared, visible, and near-ultraviolet ranges), but rendered in colors that are visible to the human eye. That is, the term “visible light image” also includes so- called “false” color images, in which the various features depicted in the images may or may not be rendered in the same color as actually reflected or emitted by the object or specimen 12.
  • radiographic image refers to images resulting from the detection of certain types of short wavelength photon radiation.
  • photon radiation will include x-ray radiation (i.e., generally regarded as photon radiation having wavelengths of a few lO's of nm or less).
  • radiographic may refer to photon radiation having wavelengths that are greater (i.e., longer) than or less (i.e., shorter) than the wavelengths typically associated with x-ray radiation.
  • one type of visible light image that may be captured by the composite imaging system 10 may comprise a simple reflected light image of the specimen 12. Such a reflected light image may be formed by detecting or capturing ambient light reflected by the specimen 12. Another type of visible light image may comprise an emitted light image. An emitted light image may be formed or obtained by capturing light emitted by the specimen 12 itself, e.g., via luminescence and/or fluorescence processes. Such visible light images of the specimen 12 may be captured or recorded by the camera 26 and displayed on display system 46, if desired.
  • Radiographic images may be obtained by using the radiation or x-ray detector assembly 34 to detect radiation from the specimen 12.
  • a common type of radiographic image may comprise an x-ray image of the specimen 12, which may be formed by detecting x-rays (e.g., from the x-ray source 36) passing through the specimen 12.
  • Another type of radiographic image may be formed by using the x-ray detector assembly 34 to detect radiation (i.e., of the appropriate wavelength) that may be emitted by radioisotopes or other radioactive substances comprising or otherwise provided in the specimen 12.
  • the various types of visible light images (including reflected and emitted light images) and radiographic images (including x-ray and radio-isotopic images) may be combined with one another to form one or more combined or composite images 14 and 16, as shown in Figures 4a and 4b.
  • the combined or composite images 14, 16 may also be referred to herein as "overlay" images, in which various combinations of the emitted light, radiographic, and/or reflected light images are superimposed on one another.
  • overlay images in which various combinations of the emitted light, radiographic, and/or reflected light images are superimposed on one another.
  • the composite image 14 depicted in Figure 4a comprises reflected and emitted light images that are superimposed on one another
  • composite image 16 depicted in Figure 4b comprises emitted light and x-ray radiographic images that are superimposed on one another.
  • the composite images provide a visual correlation of the various features and attributes captured by the various types of images. Generally speaking, such composite images are particularly useful when performing in-vivo images of living organisms, although they may be used when studying any type of object or specimen 12, either in- vivo or in-vitro.
  • the composite imaging system 10 may be used as follows to obtain various types of images (e.g., visible light images and/or radiographic images) of any of a wide variety of specimens 12.
  • the specimen 12 may comprise a mammalian organism, such as a mouse (depicted in Figures 4a and 4b), although in other embodiments, the specimen 12 may comprise a well plate 54 (depicted in Figure 2) for analyzing chemical samples disposed in the various wells of well plate 54.
  • the access door 22 ( Figure 1 ) of imaging system 10 may be moved to the closed position. When the access door 22 is closed, the imaging compartment 20 will be dark and substantially light-tight, thereby allowing the camera system 26 to capture a visible light image of the specimen 12.
  • the visible light image may comprise a reflected light image of the specimen 12 or an emitted light image produced by luminescent or fluorescent materials comprising the specimen 12. More particularly, if the specimen 12 is luminescent, then camera system 26 may directly capture an emitted light image of the specimen 12 by opening a shutter (not shown) on the camera system 26 for a time sufficient to capture the desired luminescent image. Alternatively, if a fluorescent image of the specimen 12 is to be captured, then the fluorescent material(s) in the specimen 12 may first need to be activated or excited before it will emit substantial amounts of light. The fluorescent material in the specimen 12 may be activated or excited by illuminating the specimen 12 with excitation light of the appropriate wavelength.
  • the excitation light may be provided by activating an individual light source or sources 30 ( Figure 3) of lighting system 28. After an appropriate period of time, the individual light source(s) 30 of lighting system 28 may be extinguished. An emitted light image of the now- fluorescing specimen 12 may be captured by camera system 26.
  • the imaging system 10 may also capture a reflected light image of the specimen 12.
  • the reflected light image may also be acquired by camera system 26.
  • Light sufficient for illuminating the specimen 12 may be provided by activating one or more of the light sources 30 of lighting system 28, which may be specifically provided for this purpose.
  • a radiographic image of the specimen 12 may also be obtained, again either before or after the capture of any desired visible light images.
  • an x-ray radiographic image may be obtained by operating the x-ray source 36 to produce or otherwise direct x-rays (not shown) toward the specimen 12 provided on platform 24. After passing through the stage 24 and specimen 12, the x- rays are detected by x-ray detector assembly 34. During the x-ray detection process, the detector assembly 34 is activated to detect x-rays passing through the specimen 12.
  • the activated detector assembly 34 is moved along the gantry assembly 38, i.e., in the longitudinal direction 40, from the first position on the left-hand side of gantry assembly 38 (i.e., as shown in Figure 2) to the second position (not shown, on the right-hand side of gantry assembly 38).
  • the movement of the detector assembly 34 along the longitudinal direction 40 during the detection process will allow a two-dimensional x-ray image of the specimen 12 to be produced (e.g., by stitching together various image portions acquired by detector assembly 34 as it is moved along the gantry assembly 38).
  • the x-ray source 36 can be deactivated or otherwise caused to stop directing x-rays toward the specimen 12.
  • the visible light images (e.g., comprising reflected and/or emitted light images) captured by camera system 26 may be displayed on display system 46 ( Figure 1 ) operatively associated with the imaging system 10.
  • a reflected light image of the specimen 12 may be combined with an emitted light image of the specimen 12 to produce a composite image 14 that comprises both the emitted and reflected light images of the specimen 12. See Figure 4a.
  • a radiographic image (e.g., comprising an x-ray image) captured by x-ray imaging system 32, may also be displayed on display system 46.
  • the radiographic image may be combined with one or more images of the other types, such as an emitted light image, to produce a composite image 16, as best seen in Figure 4b.
  • a significant advantage of the present invention is that both types of images (i.e., visible light images and radiographic images) may be captured nearly simultaneously, typically in rapid succession, thereby eliminating the need to move the specimen or otherwise disturb the imaging system or set-up between image capture modes.
  • the radiographic (e.g., x-ray) images may also be acquired, processed, and displayed in substantially the same manner (and with the same image processing systems) used for the visible light images.
  • the x-ray image detector 34 dispenses with the need to use film-based x-ray imaging systems that are typically used in these types of molecular imaging systems.
  • the ability to dispense with such film-based systems allows for the elimination of the cumbersome scintillator plates and film holders associated with conventional systems.
  • the x-ray image detector 34 generally produces a much higher resolution than do film-based systems.
  • the radiation or x-ray image detector also directly produces image data in the same type of image format (e.g., electronic) as the visible light images produced by the camera system 26. Consequently, subsequent image processing operations and composite image formation steps may be conveniently performed without the need to first develop the x-ray film, then scan the x-ray film to produce electronic image data.
  • a composite imaging system 10 may comprise a generally rectangularly-shaped housing or main enclosure 18 that is configured to house and support the various components and subsystems required to perform various types of molecular imaging processes, as will be described herein.
  • the main housing or enclosure 18 may be provided with various external finish panels 52 that cover or overlay the underlying housing or main enclosure structure 18.
  • the composite imaging system 10 is designed or configured to be connected to a separate computer system 42, e.g., via a suitable data link 44, to allow a user to operate the composite imaging system 10 and to view the images produced by the imaging system 10 on a display system 46 associated with computer system 42.
  • Computer system 42 may also be provided with keyboard assembly 48 and a pointing devices, such as a mouse 50, to allow the user to conveniently operate and control the computer system 42 and/or imaging system 10.
  • a pointing devices such as a mouse 50
  • other arrangements are possible, as would become apparent to persons having ordinary skill in the art after having become familiar with the teachings provided herein.
  • computer systems 42 suitable for use with such molecular imaging systems are well-known in the art and could be readily provided by persons having ordinary skill in the art after having become familiar with the teachings provided herein, the particular computer system 42 and associated components will not be described in further detail herein.
  • the computer system 42 may be provided with one or more software packages or computer programs that allow the computer 42 to interface with the imaging system 10.
  • the computer program(s) may be configured to allow the computer 42 to control various functions and operations of the imaging system 10.
  • the computer program(s) may be configured to perform various image processing functions to allow the various images (e.g., composite images 14, 16 shown in Figures 4a and 4b) to be displayed on display system 46 in the manner described herein.
  • the main enclosure 18 of composite image system 10 may be provided with an access door 22 that can be moved vertically between a closed position (shown in Figure 1) and an opened position (not specifically illustrated in the drawing figures) to allow a user to access an imaging compartment 20 defined by the main enclosure 18. See Figure 2.
  • the imaging compartment or chamber 20 is sized to receive one or more objects or specimens 12 to be imaged.
  • Objects or specimens 12 that may be used with imaging system 10 include samples that may be provided in a well plate 54 as well as living organisms, such as a mouse (depicted in Figures 4a and 4b). Other types of objects or specimens 12 may be imaged for other purposes as well, as would become apparent to persons having ordinary skill in the art after having become familiar with the teachings provided herein.
  • the imaging system 10 also may include an imaging system sub-assembly 56.
  • Sub-assembly 56 may comprise the object platform or stage 24 as well as a mounting or support structure 58.
  • the object platform 24 may be moveably mounted to the sub-assembly 56 so that the object platform 24 can be moved vertically toward and away from the support structure 58, i.e., generally in the directions indicated by arrows 60.
  • the support structure 58 may also be configured to receive camera system 26, lighting system 28, and various components of the radiographic or x-ray imaging system 32.
  • Support structure 58 may also be configured to receive various other components and systems (e.g., motor and camera control systems as well as a cooling system for the camera system 26) that may be required or desired to capture various kinds of images (e.g., visible and radiographic images) of the specimen 12.
  • various other components and systems e.g., motor and camera control systems as well as a cooling system for the camera system 26
  • images e.g., visible and radiographic images
  • camera system 26 may be mounted to support structure 58 so that the camera system 26 is located or positioned on a first side 62 of object platform 24 ( Figure 2).
  • the camera system 26 may include a lens assembly 64 ( Figure 3) that defines a field of view (illustrated by lines 66, Figure 2) that may be substantially coextensive with the imaging platform or stage 24, thereby allowing the camera system 26 to capture a visible light image of the object or specimen 12 provided on the object platform 24.
  • Camera system 26 of imaging system 10 will generally comprise a high-performance, high-sensitivity camera suitable for capturing the extremely low light intensities associated with luminescent or fluorescent objects or specimens 12.
  • the light sensitive element (not shown) of the camera system 26 it typically cooled to very low temperatures in order to improve the sensitivity, dynamic range, and signal-to-noise ratio of camera system 26.
  • Camera system 26 of image system 10 may comprise any of a wide range of high-sensitivity cameras that are now known in the art or that may be developed in the future that are or would be suitable for capturing the extremely low light intensities associated with luminescent and/or fluorescent objects or specimens 12. Consequently, the present invention should not be regarded as limited to any particular camera system 26. Camera systems suitable for use as camera system 26 may be obtained from Spectral Instruments, Inc., of Arlington, AZ.
  • lighting system 28 is also mounted to support structure
  • lighting system 28 may comprise a generally round or disk-shaped structure that is provided with a central opening 68 therein that is sized to receive the lens assembly 64 of camera system 26. The arrangement is such that the field of view 66 of camera system 26 will be substantially unobstructed by the lighting system 28.
  • Lighting system 28 may be provided with a plurality of individual light sources 30 suitable for illuminating the specimen 12 with light in various desired wavelength regions or bands. More specifically, the light sources 30 may be used to produce excitation light of a wavelength range suitable for exciting the particular fluorescent material in the object 12 to be imaged.
  • each of the various light sources 30 is configured or designed to produce light in a different wavelength range. Accordingly, a wide range of fluorescent materials may be excited or made to fluoresce by simply activating the particular light source or sources 30 comprising lighting system 28 that produce light in a wavelength range suitable for exciting the particular fluorescent material to be imaged.
  • several of the individual light sources 30 comprise broadband (e.g., white light) sources.
  • the broad-band or white light sources may be used to illuminate the object 12 to allow the camera system 26 to capture a reflected light image thereof.
  • various components of the x-ray imaging system 32 also may be mounted to the support structure 58 of imaging system 10. More specifically, and in the embodiment shown and described herein, the x-ray detector 34 and gantry assembly 38 are mounted to the support structure 58. Accordingly, the x-ray detector 34, like camera system 26, is also located or positioned on the first side 62 of object platform 24.
  • X-ray source 36 is mounted on the second side 70 of the object platform 24, generally on the bottom or lower section of imaging system 10, as best seen in Figure 3. When activated, the x-ray source 36 directs x-rays (not shown) toward the second side 70 of the object platform 24.
  • X-ray source 36 may comprise any of a wide range of x-ray sources that are now known in the art or that may be developed in the future that are, or would be, suitable for the intended application. Consequently, the present invention should not be regarded as limited to any particular type of x-ray source. However, by way of example, in one embodiment, x-ray source 36 may comprise an x-ray source available from Newton Scientific, Inc., of Cambridge, MA (US), as model no. NS-291.
  • the x-ray detector 34 may comprise an x-ray sensor element 72 that extends along a transverse direction 74.
  • the x-ray detector 34 (and sensor element 72) is moveably mounted to the gantry assembly 38 that is mounted to support structure 58 of imaging system 10.
  • the gantry assembly 38 allows the x-ray detector 34 to be moved or translated in a longitudinal direction 40 that is generally perpendicular to the transverse direction 74.
  • the x-ray detector 34 is moveable between a first position, e.g., on the left side of the camera lens assembly 64 (which position is illustrated in Figures 2, 3, 5, and 6), and a second position, e.g., on the right side of the camera lens assembly 64.
  • the x-ray detector 34 (and sensor element 72) is moveable in the longitudinal direction 40, across the field of view 66 ( Figure 2) of camera system 26.
  • the x-ray detector 34 may comprise any of a wide range of x-ray detectors that are now known in the art or that may be developed in the future that are, or would be, suitable for the intended application. Consequently, the present invention should not be regarded as limited to any particular type of x-ray detector 34.
  • the x-ray detector 34 comprises an x-ray sensor available from Hamamatsu Photonics of Japan.
  • This particular x-ray detector comprises a relatively long, narrow or strip-like sensor element 72 that comprises 4096 picture elements or "pixels" in the long direction (i.e., along transverse direction 74) and 128 pixels in the short direction (i.e., along the longitudinal direction 40).
  • the detector 34 is operated in a time delay integration mode in which the light is shifted among the various pixels of the sensor element 72 at the same rate as the detector assembly 34 is moved in the longitudinal direction 40.
  • the x-ray detector 34 is mounted to gantry assembly 38 that, in one embodiment, may comprise a pair of guide members or guide rails 76, 78 that are mounted to sub-assembly 58 so that they are located in generally parallel, spaced-apart relation.
  • An actuator system 80 operatively associated with the x-ray detector assembly 34 is used to move or translate the x-ray detector 34 along the guide rails 76, 78, between the first and second positions.
  • the actuator system 80 may also comprise a position sensor 82 that is operatively associated with the x-ray detector assembly 34. The position sensor 82 senses a longitudinal position of the x-ray detector assembly 34 along the guide rails 76, 78.
  • the actuator system 80 comprises a lead screw 84 mounted for rotation on guide rail 78. See Figure 7.
  • a lead screw follower or nut 86 mounted to the x-ray detector 34 and engaged with lead screw 84 moves the x-ray detector 34 along the guide rails 76, 78 (i.e., in longitudinal direction 40) in response to rotation of the lead screw 84.
  • a drive motor 88 operatively connected to lead screw 84 rotates lead screw 84, thereby causing the x-ray detector 34 to move along the guide rails 76, 78 in the longitudinal direction 40 in the manner already described.
  • the position sensor 82 may comprise a rotary encoder (not shown) operatively connected to the lead screw 84 that produces an output signal relating to the rotation of the lead screw 84.
  • a linear encoder or sensor may be used to sense linear movement or translation of the x-ray detector 34 along the guide rails 76, 78.
  • the composite imaging system 10 of the present invention may also comprise an image data processing system 90, portions of which (e.g., hardware) may be provided within the imaging system 10 itself, and other portions of which (e.g., software) may be provided on computer system 42.
  • the image data processing system 90 may be operatively associated with the x-ray detector system 34 and may process or stitch together various image portions or segments produced by the x-ray detector system 34 (e.g., operated in the time delay integration mode) to form a two-dimensional x-ray image of the object or specimen 12.
  • the image data processing system 90 may also be operatively associated with the actuator system 80, the position sensing system 82, and the x-ray source 36.
  • the image data processing system 90 may operate those systems in conjunction with the x-ray detector system 34 in accordance with the methods described herein in order to capture an x-ray image of the object 12.
  • the image data processing system 90 may also be operatively associated with the camera system 26 and lighting system 28 and may be used to process visible light images captured from the camera system 26 as well.
  • the composite imaging system 10 may be operated as follows to capture both visible light images and x-ray images of an object or specimen 12 positioned on the object platform 24.
  • the image data processing system 90 may be programmed or operated to control the various elements and devices in the manner described to perform the various steps in the methods described herein.
  • other operational architectures are possible, as would become apparent to persons having ordinary skill in the art after having become familiar with the teachings provided herein. Consequently, the present invention should not be regarded as limited to the particular operational architecture described herein.
  • a visible light image of the object 12 may be captured after the user has closed the door
  • Lighting system 28 may be used to illuminate the object 12 in order to capture a reflected light image of the object 12.
  • a visible light image of light being emitted by the object 12 itself e.g., as a result of luminescence or fluorescence, may be obtained by allowing the camera system 26 to detect a sufficient number of photons from the object 12.
  • the x-ray detector system 34 will remain in either the first position or the second position so as not to obstruct the field of view 66 of camera system 26.
  • a radiographic image, such as an x-ray image, of the object 12 may be captured or obtained by activating the x-ray source 36 located on the second side 70 of the object platform 24.
  • the radiographic (e.g., x-ray) image may be obtained either prior to or after the visible light image process described above.
  • the activated x-ray source 36 will direct x-rays (not shown) toward the second side 70 of the object platform 24. Thereafter, the x-rays will penetrate the object platform 24 as well as the object 12 provided thereon.
  • the x- ray detector 34 will detect x-rays passing through the object platform 24 and the object 12.
  • the x-ray detector 34 is operated in a time delay integration mode in which the light is shifted across the various pixels of sensor element 72 at the same rate as the detector 34 is moved in the longitudinal direction 40. Operation in such a time delay integration mode will allow the detector 34 to acquire or integrate more radiation from the specimen 12, thereby improving the quality of the resultant image data.
  • the detector 34 will continue to detect such x-rays as it is moved or translated (i.e., in longitudinal direction 40) from the first position to the second position, across the field of view 66 of camera system 26.
  • a two-dimensional x-ray image may be constructed by combining or stitching together the plurality of image portions or segments obtained by the x-ray detector 34 as it moves along the longitudinal direction 40.
  • the various image types (e.g., visible and radiographic) of a specimen or specimens 12 captured by the imaging system 10 may be displayed on the display system 46 ( Figure 1).
  • visible light images e.g., comprising reflected and/or emitted light images
  • a reflected light image of specimens 12 may be combined with an emitted light image of specimens 12 to produce a composite image 14 that comprises both the emitted and reflected light images. See Figure 4a.
  • a radiographic image e.g., comprising an x-ray image
  • the radiographic image may be combined with one or more images of the other types (e.g., an emitted light image) to produce a composite image 16, as best seen in Figure 4b.

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Abstract

Un système d'imagerie peut comprendre une enceinte principale qui présente au moins une porte d'accès délimitant un compartiment d'imagerie sensiblement étanche à la lumière lorsque la porte d'accès se trouve en position fermée. Une plateforme porte-objet située dans l'enceinte principale maintient un objet devant être imagé. Un système photographique placé sur un premier côté de la plateforme porte-objet sert à capturer une image de rayonnement visible de l'objet. Un détecteur de rayonnement disposé sur le premier côté de la plateforme porte-objet est mobile et peut passer d'une première position à une seconde position dans un champ de vision du système photographique. Le détecteur de rayonnement permet de capturer une radiographie de l'objet grâce au déplacement dudit détecteur de rayonnement de la première à la seconde position et grâce à la détection simultanée du rayonnement en provenance de l'objet.
PCT/US2011/049987 2010-09-01 2011-08-31 Procédés et systèmes permettant de produire des données image de rayonnement visible et de radiographie WO2012030973A2 (fr)

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Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2981813B1 (fr) 2013-04-04 2019-03-27 Illinois Tool Works Inc. Tomographie hélicoïdale par ordinateur
JP6105806B2 (ja) 2013-04-12 2017-03-29 イリノイ トゥール ワークス インコーポレイティド 高解像度コンピュータートモグラフィー
CN105452804B (zh) * 2013-05-10 2019-01-15 株式会社尼康 X线装置及构造物的制造方法
WO2015134277A1 (fr) 2014-03-05 2015-09-11 Faxitron Bioptics, Llc Système et procédé pour imagerie multiaxiale de spécimens
US10067065B1 (en) * 2014-06-23 2018-09-04 Amazon Technologies, Inc. Electronic device inspecting system and method
WO2017040977A1 (fr) 2015-09-04 2017-03-09 Faxitron Bioptics, Llc Dispositif d'imagerie d'échantillons multi-axe avec marqueurs d'orientation incorporés
US10168288B2 (en) * 2015-09-21 2019-01-01 General Electric Company System for radiography imaging and method of operating such system
US11058388B2 (en) 2016-05-20 2021-07-13 Perimeter Medical Imaging, Inc. Method and system for combining microscopic imaging with X-Ray imaging
WO2018085719A1 (fr) * 2016-11-04 2018-05-11 Hologic, Inc. Système de radiographie d'échantillon
US11207036B2 (en) * 2017-08-16 2021-12-28 KUB Technologies, Inc. System and method for cabinet x-ray systems with automatic specimen/sample alert
US11317881B2 (en) 2017-09-11 2022-05-03 Faxitron Bioptics, Llc Imaging system with adaptive object magnification
US10729399B2 (en) * 2018-03-01 2020-08-04 KUB Technologies, Inc. System and method for cabinet X-ray system with camera and X-ray images superimposition
ES2939882T3 (es) 2018-12-26 2023-04-27 Hologic Inc Obtención de imágenes de tejido en presencia de líquido durante procedimiento de biopsia
EP3911918A4 (fr) * 2019-01-17 2022-09-21 University Health Network Système multimodal pour la visualisation et l'analyse d'échantillons chirurgicaux
CN109490348A (zh) * 2019-01-21 2019-03-19 长沙开元仪器有限公司 Xrf探测器及用于xrf探测器的标样校准装置
JP1670449S (fr) * 2020-02-18 2020-10-19

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009151554A2 (fr) 2008-06-13 2009-12-17 Carestream Health, Inc. Support de torsion pour une rotation crâniocaudale d'animaux
US20100022866A1 (en) 2005-09-08 2010-01-28 Gilbert Feke Torsional support apparatus and method for craniocaudal rotation of animals

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800079A (en) 1972-12-18 1974-03-26 Ibm Compensation for a scanning system
US3871767A (en) 1973-06-20 1975-03-18 Science Applic Inc Apparatus for determining luminescence
US3949162A (en) 1974-02-25 1976-04-06 Actron Industries, Inc. Detector array fixed-pattern noise compensation
US4196994A (en) 1977-12-19 1980-04-08 Polaroid Corporation Desensitized photoelectric detector unit
US4199678A (en) * 1979-01-31 1980-04-22 U.S. Philips Corporation Asymmetric texture sensitive X-ray powder diffractometer
US4585934A (en) 1979-03-05 1986-04-29 Hughes Aircraft Company Self-calibration technique for charge-coupled device imagers
US4343021A (en) 1979-08-21 1982-08-03 Ball Corporation Image sensor sensitivity variation compensator
US4298887A (en) 1980-06-09 1981-11-03 Rockwell International Corporation Non-uniformity correction in a multielement detector array
JPS5940867A (ja) 1982-06-15 1984-03-06 エレクトロニツク・ニユ−マチツク・アパラタス・アンド・コントロ−ルズ・リミテツド 蘇生装置
JPS59502060A (ja) 1982-11-20 1984-12-13 ウイザ−ド，ト−マス・パタ−ソン 試験記録装置
JPS59111738A (ja) 1982-12-16 1984-06-28 株式会社東芝 Ｘ線断層撮影装置
US4772453A (en) 1985-03-01 1988-09-20 Lisenbee Wayne F Luminiscence measurement arrangement
US4687325A (en) 1985-03-28 1987-08-18 General Electric Company Three-dimensional range camera
US4797000A (en) 1986-01-02 1989-01-10 Artel Comparative colorimeter
DE3623601C2 (de) 1986-07-12 1997-01-16 Berthold Lab Prof Dr Meßgerät für Bio- und Chemilumineszenz
US4885544A (en) 1987-12-28 1989-12-05 Kabushiki Kaisha Toshiba Determination circuit for data coincidence
JP2934455B2 (ja) * 1988-08-26 1999-08-16 株式会社日立製作所 Ｘ線透過画像によるはんだ付部の検査方法及びその装置
US4948975A (en) 1988-09-08 1990-08-14 The United States Of America As Represented By The Secretary Of The Air Force Quantitative luminescence imaging system
US5039868A (en) 1988-11-24 1991-08-13 Omron Corporation Method of and apparatus for inspecting printed circuit boards and the like
US5008548A (en) 1989-08-01 1991-04-16 Nahum Gat Personal UV radiometer
US5272518A (en) 1990-12-17 1993-12-21 Hewlett-Packard Company Colorimeter and calibration system
US5101229A (en) 1990-12-31 1992-03-31 Eastman Kodak Company Light lock
US5401465A (en) 1992-05-05 1995-03-28 Chiron Corporation Luminometer with reduced sample crosstalk
GB9213737D0 (en) 1992-06-29 1992-08-12 Nycomed Pharma As Light measurement
US5436718A (en) 1993-07-30 1995-07-25 Biolumin Corporation Mutli-functional photometer with movable linkage for routing optical fibers
US5414258A (en) 1993-11-22 1995-05-09 Angstrom Technologies, Inc. Apparatus and method for calibration of fluorescence detectors
US7255851B2 (en) 1994-07-01 2007-08-14 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US6649143B1 (en) 1994-07-01 2003-11-18 The Board Of Trustees Of The Leland Stanford Junior University Non-invasive localization of a light-emitting conjugate in a mammal
US5515161A (en) 1994-07-06 1996-05-07 Becton Dickinson And Company Calibration device for fluorescence photometers
US6038038A (en) 1994-08-24 2000-03-14 Xerox Corporation Method for determining offset and gain correction for a light sensitive sensor
DE69530323T2 (de) 1994-09-02 2004-02-12 BD Biosciences, Systems and Reagents, Inc., San Jose Verfahren und vorrichtung zur eichung eines optischen abtasters
US5672881A (en) 1994-09-14 1997-09-30 Glyko, Inc. Charge-coupled device imaging apparatus
US5840572A (en) 1994-10-11 1998-11-24 United States Of America As Represented By The Secretary Of The Navy Bioluminescent bioassay system
JP2675532B2 (ja) 1994-12-20 1997-11-12 株式会社バイオセンサー研究所 化学発光測定装置
US5680492A (en) 1995-08-01 1997-10-21 Cogent Light Technologies, Inc. Singular fiber to bundle illumination with optical coupler
JP3819032B2 (ja) 1995-08-24 2006-09-06 ザ・テキサス・エイ・アンド・エム・ユニバーシティ・システム 組織およびその他のランダム媒体における蛍光寿命に基づく撮像および分光分析
US5587583A (en) 1995-09-06 1996-12-24 Hughes Electronics Thermal imaging device
CA2171574C (fr) 1996-03-12 2000-10-03 Brian W. Tansley Appareil de mesure photometrique
EP1985995A3 (fr) 1996-08-16 2009-09-16 GE Healthcare Niagara Inc. Système d'imagerie numérique pour analyses en plaques à puits, gels et buvards
FR2754457B1 (fr) 1996-10-11 1999-04-16 Boussignac Georges Appareil d'assistance respiratoire
GB9626932D0 (en) 1996-12-24 1997-02-12 Lumitech Limited Assay methods and kits therefor
US5898802A (en) 1997-03-27 1999-04-27 Cogent Light Technologies, Inc. Coupling method and apparatus for coupling polymer fibers to a light source for improving power handling capabilities of the polymer fibers
US5986271A (en) 1997-07-03 1999-11-16 Lazarev; Victor Fluorescence imaging system
US6097025A (en) 1997-10-31 2000-08-01 Ljl Biosystems, Inc. Light detection device having an optical-path switching mechanism
AU8846498A (en) 1997-08-07 1999-03-01 Imaging Research, Inc. A digital imaging system for assays in well plates, gels and blots
CA2272255C (fr) 1998-05-22 2005-05-10 David R. Snelling Mesures absolues de l'intensite lumineuse dans une incandescence excitee par laser
US6205244B1 (en) 1998-06-23 2001-03-20 Intel Corporation Method for imager device color calibration utilizing light-emitting diodes or other spectral light sources
WO2000036106A2 (fr) 1998-12-17 2000-06-22 Xenogen Corporation Evaluation non-invasive d'une reponse physiologique chez un mammifere
US6432047B1 (en) 1999-02-25 2002-08-13 Micro Medical Devices, Inc. Endoscopic surgical procedures and endoscopic apparatus comprising segmented fiber optic cables
US6642499B1 (en) 1999-07-19 2003-11-04 The University Of Rochester System for photometric calibration of optoelectronic imaging devices especially streak cameras
US7581191B2 (en) 1999-11-15 2009-08-25 Xenogen Corporation Graphical user interface for 3-D in-vivo imaging
US6614452B1 (en) 1999-11-15 2003-09-02 Xenogen Corporation Graphical user interface for in-vivo imaging
US6867348B1 (en) 1999-12-16 2005-03-15 Xenogen Corporation Methods and compositions for screening for angiogenesis modulating compounds
US6735274B1 (en) * 2000-02-15 2004-05-11 Koninklijke Philips Electronics N.V. Clinical screening CT systems
RU2182328C2 (ru) 2000-02-17 2002-05-10 Институт молекулярной биологии им. В.А. Энгельгардта РАН Флуоресцентный микроскоп
US6775567B2 (en) 2000-02-25 2004-08-10 Xenogen Corporation Imaging apparatus
US6377353B1 (en) 2000-03-07 2002-04-23 Pheno Imaging, Inc. Three-dimensional measuring system for animals using structured light
EP1248272B1 (fr) * 2001-03-24 2003-02-12 YXLON International X-Ray GmbH Procédé d'inspection d'objets, notamment pour le dépistage de défauts ou d'irrégularités par rayons-x, et dispositif pour la mise en oeuvre du procédé
US7449567B2 (en) 2001-04-12 2008-11-11 Xenogen Corporation Isolation and identification of mouse and human transcription control elements associated with cytochrome expression
US7403812B2 (en) 2001-05-17 2008-07-22 Xenogen Corporation Method and apparatus for determining target depth, brightness and size within a body region
US6919919B2 (en) 2002-02-06 2005-07-19 Xenogen Corporation Light calibration device for use in low level light imaging systems
US7116354B2 (en) 2001-06-20 2006-10-03 Xenogen Corporation Absolute intensity determination for a light source in low level light imaging systems
US7298415B2 (en) 2001-07-13 2007-11-20 Xenogen Corporation Structured light imaging apparatus
US7113217B2 (en) 2001-07-13 2006-09-26 Xenogen Corporation Multi-view imaging apparatus
US6754008B1 (en) 2001-09-17 2004-06-22 Xenogen Corporation Imaging lens arrangement designed for low light conditions
DE10151670A1 (de) * 2001-10-19 2003-05-08 Siemens Ag Bildgebungsverfahren und Bildgebungsvorrichtung, insbesondere für die Kleintierbildgebung
US7503323B2 (en) 2002-02-20 2009-03-17 Xenogen Corporation Multiple output anesthesia system
US7474398B2 (en) 2002-02-22 2009-01-06 Xenogen Corporation Illumination system for an imaging apparatus with low profile output device
US7474399B2 (en) 2002-02-22 2009-01-06 Xenogen Corporation Dual illumination system for an imaging apparatus and method
US6922246B2 (en) 2002-02-22 2005-07-26 Xenogen Corporation Bottom fluorescence illumination assembly for an imaging apparatus
US6894289B2 (en) 2002-02-22 2005-05-17 Xenogen Corporation Fluorescence illumination assembly for an imaging apparatus
SE524380C2 (sv) * 2002-03-12 2004-08-03 Xcounter Ab Exponeringsstyrning i scannerbaserad detektering av joniserande strålning
US7616985B2 (en) 2002-07-16 2009-11-10 Xenogen Corporation Method and apparatus for 3-D imaging of internal light sources
US7599731B2 (en) 2002-07-16 2009-10-06 Xenogen Corporation Fluorescent light tomography
US7198404B2 (en) * 2003-04-03 2007-04-03 Siemens Medical Solutions Usa, Inc. Real-time acquisition of co-registered X-ray and optical images
US7190991B2 (en) 2003-07-01 2007-03-13 Xenogen Corporation Multi-mode internal imaging
US7555334B2 (en) 2003-10-20 2009-06-30 Xenogen Corporation Small animal light intensity monitor
US7352840B1 (en) 2004-06-21 2008-04-01 Radiation Monitoring Devices, Inc. Micro CT scanners incorporating internal gain charge-coupled devices
US7734325B2 (en) * 2004-09-21 2010-06-08 Carestream Health, Inc. Apparatus and method for multi-modal imaging
ATE500778T1 (de) * 2005-12-22 2011-03-15 Visen Medical Inc Kombiniertes röntgen- und optisches tomographie- bildgebungssystem
EP1916543A1 (fr) * 2006-10-24 2008-04-30 DKFZ Deutsches Krebsforschungszentrum, Stiftung des Öffentlichen Rechts Système d'imagerie à triple modalité
EP2375988A1 (fr) * 2008-12-11 2011-10-19 Koninklijke Philips Electronics N.V. Système et procédé de génération d'images de l'intérieur et de l'extérieur d'un patient

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100022866A1 (en) 2005-09-08 2010-01-28 Gilbert Feke Torsional support apparatus and method for craniocaudal rotation of animals
WO2009151554A2 (fr) 2008-06-13 2009-12-17 Carestream Health, Inc. Support de torsion pour une rotation crâniocaudale d'animaux

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See also references of EP2612134A4

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WO2012030973A3 (fr) 2014-03-27
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US9347894B2 (en) 2016-05-24
US20120051514A1 (en) 2012-03-01
EP2612134A2 (fr) 2013-07-10

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