WO2012020633A1 - Aiguille à demeure et ensemble d'aiguille à demeure - Google Patents

Aiguille à demeure et ensemble d'aiguille à demeure Download PDF

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Publication number
WO2012020633A1
WO2012020633A1 PCT/JP2011/066658 JP2011066658W WO2012020633A1 WO 2012020633 A1 WO2012020633 A1 WO 2012020633A1 JP 2011066658 W JP2011066658 W JP 2011066658W WO 2012020633 A1 WO2012020633 A1 WO 2012020633A1
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WO
WIPO (PCT)
Prior art keywords
groove
indwelling needle
valve body
flow path
polymer layer
Prior art date
Application number
PCT/JP2011/066658
Other languages
English (en)
Japanese (ja)
Inventor
秀憲 田邊
図師　泰伸
崇王 安齋
Original Assignee
テルモ株式会社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by テルモ株式会社 filed Critical テルモ株式会社
Publication of WO2012020633A1 publication Critical patent/WO2012020633A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/14—Infusion devices, e.g. infusing by gravity; Blood infusion; Accessories therefor
    • A61M5/158—Needles for infusions; Accessories therefor, e.g. for inserting infusion needles, or for holding them on the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
    • A61M2039/0633—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof the seal being a passive seal made of a resilient material with or without an opening
    • A61M2039/064—Slit-valve
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/22—Valves or arrangement of valves
    • A61M39/26—Valves closing automatically on disconnecting the line and opening on reconnection thereof
    • A61M2039/267—Valves closing automatically on disconnecting the line and opening on reconnection thereof having a sealing sleeve around a tubular or solid stem portion of the connector
    • A61M2039/268—Valves closing automatically on disconnecting the line and opening on reconnection thereof having a sealing sleeve around a tubular or solid stem portion of the connector wherein the stem portion is moved for opening and closing the valve, e.g. by translation, rotation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M39/00—Tubes, tube connectors, tube couplings, valves, access sites or the like, specially adapted for medical use
    • A61M39/02—Access sites
    • A61M39/06—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof
    • A61M39/0693—Haemostasis valves, i.e. gaskets sealing around a needle, catheter or the like, closing on removal thereof including means for seal penetration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/32—Needles; Details of needles pertaining to their connection with syringe or hub; Accessories for bringing the needle into, or holding the needle on, the body; Devices for protection of needles
    • A61M5/3286—Needle tip design, e.g. for improved penetration

Definitions

  • the present invention relates to an indwelling needle and an indwelling needle assembly including the same.
  • an indwelling needle assembly connected to the infusion line is punctured into the patient's blood vessel and placed in place.
  • Such an indwelling needle assembly includes a hollow outer needle, an outer needle hub fixed to the proximal end of the outer needle, an inner needle inserted into the outer needle and having a sharp needle tip, and an inner needle. It is comprised with the inner needle hub fixed to the base end (for example, refer patent document 1).
  • the outer needle hub houses a valve body (hemostatic valve) and an operation member (pusher) for opening and closing the valve body.
  • the valve element housed in the outer needle hub has a function of preventing leakage of blood flowing into the flow path in the outer needle hub via the outer needle that secures the blood vessel.
  • the valve body has a groove formed on the outer peripheral surface thereof, and is confined between the blood flowing into the flow path and the valve body through the groove. The air can escape. This prevents bubbles from remaining in the flow path and improves the safety of the indwelling needle assembly.
  • An object of the present invention is to allow air trapped between a liquid flowing in the flow path from one side of the valve body and the valve body to escape to the other side of the valve body, and the liquid is It is an object of the present invention to provide an indwelling needle and an indwelling needle assembly that can prevent entry into the other side.
  • the present invention comprises a hollow outer needle, A hub provided at a base end portion of the outer needle, having a flow channel communicating with the inside of the outer needle, and capable of connecting a tubular body to the flow channel; A valve body that is provided so as to close the flow path at an end portion or in the middle of the flow path, and has an openable / closable portion; A groove portion communicating the flow path on the one side of the valve body and the other side; A polymer layer formed on the inner surface of the groove,
  • the indwelling needle is characterized in that the polymer layer is configured to prevent passage of the liquid by being deformed or altered by contact with the liquid flowing into the groove.
  • the polymer layer absorbs the liquid flowing into the groove and swells to block the groove and prevent the liquid from passing therethrough.
  • the polymer layer is dissolved by contact with the liquid flowing into the groove and the volume is increased, thereby closing the groove and preventing the liquid from passing therethrough.
  • the polymer layer is dissolved by contact with the liquid flowing into the groove and the viscosity of the liquid is increased to prevent the liquid from passing therethrough.
  • the groove is preferably formed in the valve body.
  • the valve body has a plate-like plate-like portion in which the opening / closing portion is formed, and a cylindrical tube-like portion formed to protrude from an edge of the plate-like portion. Cylindrical, The groove is preferably formed on the outer peripheral surface of the valve body.
  • the groove portion is extended from the outer peripheral surface to the surface of the plate-like portion.
  • the flow path has a step portion
  • the valve body is disposed so that an edge of the plate-like portion contacts the stepped portion
  • the groove is preferably extended on the surface of the plate-like portion so as to be exposed from the stepped portion.
  • the groove is formed on the inner surface of the hub so as to face the flow path.
  • the groove portion extends along the extending direction of the flow path.
  • the groove has a bent or curved portion in the middle.
  • the groove has a portion whose cross-sectional area changes along the extending direction.
  • the depth of the groove is preferably 5 ⁇ m to 100 ⁇ m.
  • a plurality of the groove portions are formed along the circumferential direction of the flow path.
  • the polymer layer is preferably composed of a hydrophilic polymer.
  • the polymer layer is formed by dropping a liquid containing the hydrophilic polymer into the groove, and drying the dropped liquid after wetting and spreading on the inner surface of the groove. Preferably it is done.
  • the present invention comprises an indwelling needle of the present invention, An inner needle inserted through the outer needle, In the indwelling needle assembly, blood flows into the flow path through the outer needle when the living body surface is punctured with the inner needle.
  • FIG. 1 is a longitudinal sectional view showing a first embodiment of an indwelling needle assembly (indwelling needle) of the present invention.
  • FIG. 2 is a longitudinal cross-sectional view sequentially showing the use state of the indwelling needle assembly shown in FIG.
  • FIG. 3 is a longitudinal cross-sectional view sequentially illustrating usage states of the indwelling needle assembly shown in FIG.
  • FIG. 4 is a longitudinal cross-sectional view sequentially illustrating usage states of the indwelling needle assembly shown in FIG.
  • FIG. 5 is a longitudinal cross-sectional view sequentially illustrating usage states of the indwelling needle assembly shown in FIG. 6 is a longitudinal cross-sectional view sequentially illustrating the use state of the indwelling needle assembly shown in FIG.
  • FIG. 1 is a longitudinal sectional view showing a first embodiment of an indwelling needle assembly (indwelling needle) of the present invention.
  • FIG. 2 is a longitudinal cross-sectional view sequentially showing the use state of the indwell
  • FIG. 7 is a perspective view showing a valve body of the indwelling needle shown in FIG. 8 is a cross-sectional view of the valve body shown in FIG. 7 (a cross-sectional view taken along line AA in FIG. 7).
  • FIG. 9 is a longitudinal sectional view of the valve body shown in FIG. 7 (a sectional view taken along line BB in FIG. 7).
  • 10 is a plan view of the valve body shown in FIG.
  • FIG. 11 is a perspective view showing a valve body included in the indwelling needle assembly according to the second embodiment of the present invention.
  • FIG. 12 is a perspective view showing a valve body included in the indwelling needle assembly according to the third embodiment of the present invention.
  • FIG. 13 is a perspective view which shows the valve body which the indwelling needle assembly of this invention concerning 4th Embodiment has.
  • FIG. 14 is a longitudinal cross-sectional view which shows the valve body which the indwelling needle assembly of this invention concerning 5th Embodiment has.
  • FIG. 15 is a longitudinal sectional view showing an indwelling needle assembly of the present invention according to a sixth embodiment.
  • FIG. 1 is a longitudinal sectional view showing a first embodiment of the indwelling needle assembly of the present invention
  • FIGS. 2 to 6 are longitudinal sectional views sequentially showing usage states of the indwelling needle assembly shown in FIG. 1
  • FIG. 1 is a perspective view showing the valve body of the indwelling needle shown in FIG. 1
  • FIG. 8 is a cross-sectional view of the valve body shown in FIG. 7 (cross-sectional view taken along line AA in FIG. 7)
  • FIG. FIG. 10 is a plan view of the valve body shown in FIG. 7.
  • FIG. 10 is a longitudinal sectional view of the valve body shown in FIG.
  • the right side of FIGS. 1 to 6 is referred to as “base end” and the left side is referred to as “tip”. 1 to 7, illustration of the water-soluble polymer layer formed in the groove is omitted for convenience of explanation.
  • the indwelling needle assembly 1 shown in FIG. 1 includes an indwelling needle 11 and a puncture needle 12.
  • the indwelling needle assembly 1 includes an assembled state in which the indwelling needle 11 and the puncture needle 12 are assembled (the state shown in FIGS. 1 and 2), and an extracted state in which the puncture needle 12 is removed from the indwelling needle 11 (FIGS. 3 to 5). 6).
  • the indwelling needle assembly 1 can puncture the living body surface in the assembled state. Then, the indwelling needle 11 can be indwelled on the surface of the living body by setting it in the extracted state.
  • the connector 20 can be connected to the indwelling needle 11 placed on the surface of the living body (see FIGS. 4 to 6).
  • the connector 20 Before describing the indwelling needle assembly 1, the connector 20 will be described. As shown in FIGS. 4 to 6, the connector 20 is connected to the proximal end portion of the indwelling needle 11.
  • the connector 20 includes a tubular connector main body 201 and a lock portion 202 provided on the outer peripheral side of the connector main body 201.
  • the connector main body 201 has a tapered shape in which the outer diameter gradually decreases in the distal direction. Therefore, when connecting the connector 20, the connector main body 201 can be easily inserted in the base end part of the indwelling needle 11, Therefore The connection operation can be performed easily.
  • the lock part 202 has a cylindrical shape arranged concentrically with the connector main body 201.
  • a female screw 203 is formed on the inner peripheral portion of the lock portion 202.
  • the female screw 203 can be screwed with the male screw 32 of the outer needle hub 3 of the indwelling needle 11 described later.
  • the connection state between the connector 20 and the indwelling needle 11 is reliably maintained by screwing these screws.
  • the lock portion 202 is formed integrally with the connector main body 201, but is not limited thereto, and may be configured separately from the connector main body 201.
  • a tube (not shown) is connected to the proximal end of the connector 20.
  • a bag (not shown) filled with the infusion agent Q is connected to the proximal end of the tube.
  • the infusion needle 11 is supplied with the infusion agent from the bag in a connected state where the connector 20 is connected (see FIGS. 5 and 6).
  • the indwelling needle 11 blocks the hollow outer needle 2, the outer needle hub 3 fixed to the proximal end portion of the outer needle 2, and the flow path 31 of the outer needle hub 3. And a valve mechanism 6 to be opened.
  • the constituent material of the outer needle 2 is preferably a resin material, in particular, a soft resin material.
  • resin material include fluorine resins such as PTFE, ETFE, and PFA, olefin resins such as polyethylene and polypropylene, and these.
  • fluorine resins such as PTFE, ETFE, and PFA
  • olefin resins such as polyethylene and polypropylene, and these.
  • polyurethane polyester, polyamide, polyether nylon resin, a mixture of the olefin resin and ethylene-vinyl acetate copolymer, and the like.
  • the outer needle 2 has internal visibility. That is, the outer needle 2 is preferably composed of a transparent (colorless and transparent), colored transparent or translucent resin. Thereby, when the outer needle 2 secures a blood vessel, a phenomenon (flashback) in which the blood R flows into the transparent outer needle hub 3 through the hollow portion 45 of the inner needle 4 can be visually confirmed.
  • the constituent material of the outer needle 2 may be mixed with an X-ray contrast agent such as barium sulfate, barium carbonate, bismuth carbonate, and tungstic acid to have a contrast function.
  • an X-ray contrast agent such as barium sulfate, barium carbonate, bismuth carbonate, and tungstic acid to have a contrast function.
  • the outer needle hub 3 is fixed in a liquid-tight manner by the method.
  • the outer needle hub 3 is formed of a tubular member, and its inner cavity functions as the flow path 31.
  • the flow path 31 communicates with the lumen 21 of the outer needle 2.
  • the valve mechanism 6 is housed and disposed in the flow path 31.
  • the lumen portion of the outer needle hub 3 is also used as a storage portion for storing the valve mechanism 6 in addition to the flow path 31.
  • a tapered portion 312 is formed at the distal end of the flow channel 31 in which the inner diameter of the wall 311 that defines the flow channel 31 gradually decreases in the distal direction.
  • the base end portion of the flow path 31 has a tapered shape in which the inner diameter of the wall portion 311 gradually increases in the base end direction.
  • the connector body 201 of the connector 20 can be inserted into the proximal end portion of the tapered flow path 31.
  • the wall portion 311 of the flow path 31 and the outer peripheral portion 204 of the connector main body 201 are brought into close contact with each other, thereby maintaining liquid tightness.
  • a male screw 32 that is screwed with the female screw 203 of the lock portion 202 of the connector 20 is formed on the outer periphery of the proximal end of the outer needle hub 3.
  • the proximal end portion of the outer needle hub 3 is a connection portion to which the connector 20 is connected.
  • a stepped portion 35 having a distal end with a diameter reduced with respect to the proximal end is formed in the middle of the flow path 31 .
  • a plurality of protrusions 36 are formed along the circumferential direction so as to protrude toward the center of the flow path 31 in the middle of the flow path 31 and on the base end side of the step portion 35. Yes.
  • a valve body 7 to be described later is positioned so as to be sandwiched between the step portion 35 and the plurality of protrusions 36.
  • the valve mechanism 6 is accommodated in the outer needle hub 3.
  • the valve mechanism 6 shuts and opens the flow path 31 and includes a valve body 7 and an operation member 8 that opens and closes the valve body 7.
  • the valve body 7 is installed in the middle of the flow path 31 so as to close the flow path 31.
  • the valve body 7 is provided so as to come into contact with the stepped portion 35 formed in the flow path 31 from the proximal end side, thereby preventing displacement toward the distal end side in the flow path 31.
  • the valve body 7 is prevented from being displaced toward the proximal end in the flow path 31 by a stepped portion 723 (described later) of the valve body 7 being hooked on the protrusion 36.
  • the valve body 7 has a bottomed cylindrical shape, and has an opening / closing part 71 constituting a bottom part and a fixing part 72 constituting a side wall.
  • the valve body 7 is fixed to the flow path 31 when the outer peripheral surface of the fixing portion 72 is in close contact with the wall portion 311 of the flow path 31.
  • valve body 7 is made of an elastic material. By configuring the valve body 7 with an elastic material, the opening / closing part 71 can be opened and closed smoothly.
  • the opening / closing part 71 has a disk shape, and is composed of a plate-like part 712 in which a through hole 711 is formed in the central part.
  • the plate-like portion 712 has a surface that is perpendicular to the longitudinal direction of the flow path 31.
  • the through-hole 711 is comprised by the slit penetrated in the thickness direction of the plate-shaped part 712, for example.
  • the shape of the slit is not particularly limited, and examples thereof include a single character shape, a cross shape, and a Y shape (t-shape). With such a configuration, the opening / closing part 71 is surely a part having a self-closing property.
  • the fixing portion 72 is formed integrally with the opening / closing portion 71.
  • the fixing portion 72 is a cylindrical portion that is formed to project from the edge of the opening / closing portion 71 (plate-like portion 712) toward the proximal direction.
  • the valve body 7 is fixed to the flow path 31 by fitting the outer peripheral portion of the fixing portion 72 to the wall portion 311 of the flow path 31.
  • the fixing portion 72 has a first part 721 located on the distal end side and a second part 722 located on the proximal side relative to the first part 721,
  • the outer diameter of the part 721 is formed larger than the outer diameter of the second part 722.
  • a step 723 is formed at the boundary between the first part 721 and the second part 722.
  • the elastic material constituting the valve body 7 is not particularly limited, and examples thereof include natural rubber, isoprene rubber, butyl rubber, butadiene rubber, styrene-butadiene rubber, urethane rubber, nitrile rubber, acrylic rubber, fluorine rubber, and silicone rubber.
  • Various elastic materials such as various rubber materials (especially those vulcanized), various thermoplastic elastomers such as urethane, polyester, polyamide, olefin, and styrene, or mixtures thereof.
  • isoprene rubber it is particularly preferable to use isoprene rubber.
  • a plurality of groove portions 9 are formed in such a valve body 7.
  • the plurality of grooves 9 are formed on the outer peripheral surface (side surface) 7 a of the valve body 7. As shown in FIG. 1, each groove 9 communicates the distal end side and the proximal end side with respect to the valve body 7 of the flow path 31.
  • a plurality of air trapped between the blood R flowing into the flow path 31 from the lumen 21 of the outer needle 2 and the valve body 7 is contained. It is possible to escape from the valve body 7 to the base end side through the groove portion 9. Therefore, it is possible to perform more reliable priming, that is, it is possible to prevent air from remaining in a region on the tip side of the valve body 7 in the flow path 31. Thereby, safe treatment can be performed.
  • eight groove portions 9 are formed, and these eight groove portions 9 are formed at equiangular intervals (that is, 45 ° intervals) along the circumferential direction of the valve body 7.
  • the blood R flowing into the flow path 31 and the valve body 7 can be interposed between the indwelling needle 11 in any posture.
  • the trapped air can be released to the proximal end side of the valve body 7 through any of the grooves 9.
  • the indwelling needle 11 (indwelling needle assembly 1) is normally primed (bleeded out) in a lateral state
  • the indwelling needle 11 (indwelling needle assembly) is arranged according to the arrangement of the groove portion 9 as in this embodiment. 1) Regardless of the posture of 1), at the time of priming, almost all of the air confined between the blood that flows back into the flow path 31 and the valve body 7 is more reliably supplied to the proximal end side of the valve body 7 through the groove 9. Can escape.
  • Each groove portion 9 extends linearly along the axial direction of the valve body 7 (longitudinal direction of the flow path 31). Thereby, the air can smoothly pass through the groove 9.
  • each groove part 9 is extended from the side surface 7a of the valve body 7 to the bottom face 7b (surface of the plate-shaped part 712) so that it may not contact with the through-hole 711. Further, as shown in FIG. 10, the tip end portion 91 of each groove portion 9 is exposed from the stepped portion 35 formed in the flow channel 31 when viewed in a cross section having the longitudinal direction of the flow channel 31 as a normal line. Is formed.
  • each groove portion 9 is open to the step portion 723 of the valve body 7. Accordingly, the distal end side and the proximal end side communicate with each other from the valve body 7 of the flow path 31 through each groove portion 9.
  • the plurality of protrusions 36 are formed in the flow path 31, and these protrusions 36 are engaged with the valve body 7. The shape and arrangement are set so as not to block the proximal opening.
  • each groove 9 is not particularly limited, but is preferably about 5 ⁇ m to 100 ⁇ m, and more preferably about 50 ⁇ m.
  • the groove 9 has a sufficient cross-sectional area to allow air trapped between the blood R and the valve body 7 to escape to the proximal end side of the valve body 7.
  • the groove part 9 can be more reliably plugged by swelling of the hydrophilic polymer layer 10 as will be described later.
  • a hydrophilic polymer layer (polymer layer) 10 is formed on the inner surface of each groove 9.
  • the hydrophilic polymer layer 10 has a function of blocking the passage of the liquid in the groove portion 9 by absorbing the liquid (blood) flowing into the groove portion 9 and swelling, etc., thereby closing the groove portion 9. Yes.
  • the hydrophilic polymer layer 10 is formed on the inner surface of the region 9a formed on the side surface 7a of the valve body 7 of each groove portion 9. As shown in FIG. In other words, in the present embodiment, the hydrophilic polymer layer 10 is not formed in a portion (tip portion 91) extended to the bottom surface 7 b of the valve body 7. Since the distal end portion 91 is a portion that comes into contact with the blood R at a relatively early stage, the hydrophilic polymer layer 10 is not formed in such a portion, so that it is trapped between the blood R and the valve body 7. It is possible to effectively prevent the groove portion 9 from being blocked by swelling or the like of the hydrophilic polymer layer 10 before letting air through the groove portion 9.
  • the hydrophilic polymer layer 10 is formed on the bottom surface and both side surfaces of each groove 9, but is not limited thereto, and may be formed only on the bottom surface of the groove 9, for example. However, it may be formed only on both side surfaces.
  • the hydrophilic polymer layer 10 is deformed or denatured by contact with a liquid (blood). Specifically, the hydrophilic polymer layer 10 is dissolved in the process of ⁇ 1> swelling by absorbing liquid, and ⁇ 2> the polymer material constituting the hydrophilic polymer layer 10 being dissolved. It has at least one of the property of increasing its volume by ⁇ 3> and the property of increasing (increasing) the viscosity of the liquid by dissolution.
  • the hydrophilic polymer layer 10 having the ⁇ 1> or ⁇ 2> property has the following functions. That is, as described above, each groove portion 9 is formed to release the air trapped between the blood R flowing into the flow path 31 and the valve body 7 to the proximal end side of the valve body 7.
  • the blood R may enter the proximal end side of the valve body 7 through the groove 9.
  • the blood R that has entered the proximal end side of the valve body 7 is retained between the valve body 7 and the operation member 8, and the retained blood may become a bacterial growth source or cause thrombus formation. There is.
  • the hydrophilic polymer layer 10 swells by absorbing blood flowing into the groove 9 and closes the groove 9 by increasing the volume due to dissolution, so that the blood R passes through the groove 9 and is valved. It has a function of preventing entry into the base end side of the body 7. That is, by having such a hydrophilic polymer layer 10, air trapped between the blood R and the valve body 7 can be released to the proximal end side of the valve body 7 through the groove portion 9. It is possible to prevent blood R from entering the proximal end side of the valve body 7 through the groove 9.
  • the hydrophilic polymer layer 10 having the property ⁇ 3> deteriorates the fluidity of the blood R by increasing the viscosity of the blood R flowing into the groove 9, and the blood R passes through the groove 9. And has a function of preventing the valve body 7 from entering the base end side.
  • Such a hydrophilic polymer layer 10 is composed of a hydrophilic polymer. Thereby, the structure of the hydrophilic polymer layer 10 becomes simple.
  • the hydrophilic polymer is preferably soluble in various aqueous solvents or non-aqueous organic solvents. Thereby, formation of the hydrophilic polymer layer 10 becomes easy. Specifically, first, a coating solution obtained by dissolving the hydrophilic polymer in the various organic solvents is dropped into the groove 9 (region 9a), and the dropped coating solution is applied to the groove 9 using a capillary phenomenon. Wet and spread inside. Then, after the coating liquid wets and spreads on the inner surface of the groove 9, the hydrophilic polymer layer 10 can be formed on the inner surface of the groove 9 by drying the coating liquid and volatilizing the solvent. According to such a manufacturing method, the thin film-like hydrophilic polymer layer 10 can be easily formed.
  • the formation method of the hydrophilic polymer layer 10 is not limited to this, For example, you may form by vapor deposition.
  • the hydrophilic polymer is constructed with a crosslinked structure by being given external energy such as heat, light, radiation (electron beam, gamma ray, etc.).
  • external energy such as heat, light, radiation (electron beam, gamma ray, etc.).
  • the hydrophilic polymer constituting the hydrophilic polymer layer 10 is not particularly limited, and examples thereof include acrylamide-acrylates such as polyvinylpyrrolidone, methyl vinyl ether-maleic anhydride copolymer, dimethylacrylamide-glycidyl methacrylate copolymer, and the like.
  • Water-soluble synthetic polymers such as copolymers, sodium polyacrylate, polyacrylamide, polystyrene sulfonate, polyvinyl alcohol, polyethylene osidide, and polyethyleneimine, and water-soluble semi-polymers such as carboxymethyl starch, dialdehyde starch, carboxymethyl cellulose, and hydroxyethyl cellulose.
  • Examples include rigid polymers, water-soluble natural polymers such as tannin, lignin, alginic acid, gum arabic, guar gum, tragacanth gum, gelatin, casein, and collagen. Door can be.
  • hydrophilic polymer layers 10 formed using these materials those having a crosslinked structure by being given external energy such as heat, light, and radiation absorb ⁇ 1> liquid.
  • the material that does not substantially form the crosslinked structure is dissolved.
  • the property of increasing the volume by dissolution or the property of increasing (increasing) the viscosity of the liquid by ⁇ 3> dissolution can be exhibited.
  • the properties of the hydrophilic polymer layer 10 change depending on the presence or absence of crosslinking.
  • the thickness (average thickness) of the hydrophilic polymer layer 10 is not particularly limited as long as it does not block the groove 9 in a state where liquid is not absorbed and can close the groove 9 in a state where liquid is absorbed. Although not limited, for example, it is preferably about 0.1 ⁇ m to 1 ⁇ m.
  • the operation member 8 is a member for opening / closing the opening / closing part 71 of the valve body 7.
  • the operation member 8 is supported so as to be movable along the longitudinal direction of the flow path 31. Therefore, in the indwelling needle 11, the operation member 8 is moved in the distal direction from the first state (see FIGS. 1 to 3) in which the operation member 8 is located on the proximal end side with respect to the opening / closing part 71.
  • a second state see FIGS. 4 to 6 that penetrates the opening / closing part 71 and protrudes from the opening / closing part 71 can be taken.
  • the opening / closing part 71 is closed by self-occlusion. Thereby, the flow path 31 is interrupted
  • the opening / closing part 71 is forcibly opened by the penetration of the operation member 8. Thereby, the front end side and the base end side of the flow path 31 are opened via the valve mechanism 6.
  • the operation member 8 is configured by a tubular member. When the operation member 8 moves, the outer peripheral portion of the operation member 8 may slide on the wall portion 311 of the flow path 31. Thereby, the movement is performed stably.
  • the base end enlarged portion 84 whose inner diameter is increased is formed on the outer peripheral portion of the base end of the operation member 8.
  • the inner diameter of the base end enlarged diameter portion 84 is larger than the inner diameter of the connector main body 201 of the connector 20.
  • the outer peripheral portion of the distal end of the operation member 8 is formed with two enlarged-end portions (protrusions) 81a and 81b whose outer diameter is increased, that is, projecting along the circumferential direction.
  • the tip enlarged portion 81b of these tip enlarged portions 81a and 81b functions as an engaging portion that engages with the opening / closing portion 71 of the valve body 7 in the second state. .
  • the tip enlarged diameter portions 81a and 81b are each tapered. Thereby, when the operating member 8 penetrates the opening / closing part 71 of the valve body 7, the tip diameter-enlarged parts 81a and 81b can surely spread the opening / closing part 71 outward in this order, and thus the penetration Is easily done. And the part (front-end
  • this protruding portion is referred to as a “protruding portion 82”.
  • the indwelling needle assembly 1 in the assembled state is punctured and the outer needle 2 secures a blood vessel
  • the blood R flows from the distal end opening 22 of the outer needle 2 to the flow path 31.
  • This inflowing blood R remains in the flow path 31 even in a decomposed state (see FIG. 3).
  • the connector 20 is connected to the indwelling needle 11, the indwelling needle 11 will be in a 2nd state (refer FIG. 4), and administration of the infusion agent Q to a biological body will be attained (refer FIG. 5, FIG. 6).
  • the puncture needle 12 includes an inner needle 4 and an inner needle hub 5 fixed to the proximal end portion of the inner needle 4.
  • the inner needle 4 is inserted through the outer needle 2, and the distal end portion of the inner needle hub 5 is inserted and fitted into the proximal end portion of the outer needle hub 3.
  • the indwelling needle 11 is in the first state, and the inner needle 4 is inserted through the valve body 7 and the operation member 8 all together.
  • the inner needle 4 has a sharp needle tip 41 at the tip.
  • the length of the inner needle 4 is set to such a length that at least the needle tip 41 protrudes from the distal end opening 22 of the outer needle 2 when in the assembled state.
  • the surface of the living body can be punctured by the needle tip 41.
  • the inner needle 4 may be a solid needle, but is preferably a hollow needle.
  • the blood flows into the hollow portion 45 of the inner needle 4 when the inner needle 4 punctures a blood vessel, so that the flashback of the blood R can be confirmed.
  • the inner needle 4 is a solid needle, it is possible to ensure a sufficient strength while reducing the outer diameter. Further, by making the inner needle 4 a solid needle, when the puncture needle 12 is discarded after the operation is finished, there is no risk that blood remains in the inner needle 4 or the blood flows out, High safety.
  • the inner needle 4 has a structure having both a hollow portion and a solid portion, for example, by filling a part of the lumen of the hollow needle, the distal end side is hollow and the proximal end side is solid.
  • the cost of the inner needle 4 can be aimed at by comprising the whole with one member.
  • a groove 44 is formed in the outer peripheral portion of the inner needle 4 so as to be recessed along the longitudinal direction of the inner needle 4.
  • the groove 44 functions as an introduction path for introducing the blood R into the lumen 21 of the outer needle 2 when the blood vessel is punctured.
  • the blood R introduced from the groove 44 flows into the gap between the inner needle 4 and the outer needle 2. Thereby, the flashback of blood R can be confirmed reliably from an early stage. Then, the blood R passes through the lumen 21 of the outer needle 2 and flows into the flow path 31 of the outer needle hub 3 (see FIG. 2).
  • Examples of the constituent material of the inner needle 4 include metal materials such as stainless steel, aluminum or an aluminum alloy, titanium or a titanium alloy.
  • the inner needle hub 5 is fixed (fixed) to the proximal end portion of the inner needle 4.
  • the inner needle hub 5 has a tubular shape, and an air filter (not shown) is installed at the base end opening.
  • the inner needle hub 5 and the outer needle hub 3 described above are each preferably made of a transparent (colorless and transparent), colored transparent or translucent resin to ensure internal visibility. Thereby, when the outer needle 2 secures a blood vessel, the flashback of the blood R flowing in through the groove 44 of the inner needle 4 described above can be visually confirmed.
  • the constituent materials of the outer needle hub 3, the inner needle hub 5, and the operation member 8 are not particularly limited, and for example, polyolefins such as polyethylene, polypropylene, ethylene-vinyl acetate copolymer, polyurethane, polyamide, polyester, polycarbonate, respectively. And various resin materials such as polybutadiene and polyvinyl chloride.
  • the indwelling needle assembly 1 is brought into the assembled state shown in FIG.
  • an infusion bag filled with the infusion agent Q is connected to the connector 20 in advance, so that the infusion agent Q can be supplied.
  • the indwelling needle assembly 1 in an assembled state is grasped, and the patient's blood vessel is punctured.
  • the blood R flows into the proximal direction of the lumen 21 of the outer needle 2 through the groove 44 of the inner needle 4 due to blood pressure. This can be confirmed in the outer needle hub 3 (see FIG. 2).
  • the indwelling needle assembly 1 is further advanced toward the distal end by a minute distance.
  • the blood R that has flowed in reaches the place where the valve element 7 of the flow path 31 is located.
  • the air trapped between the blood R and the valve body 7 escapes to the proximal end side of the valve body 7 through the groove 9, and then the blood R flows into the groove 9,
  • the hydrophilic polymer layer 10 formed on the inner surface absorbs blood R and swells, and the groove 9 is closed. Thereby, it is possible to prevent air from remaining on the distal end side of the valve body 7 of the flow path 31 and to prevent blood R from entering the proximal end side of the valve body 7. Can do.
  • the outer needle hub 3 of the indwelling needle 11 is fixed to the skin with an adhesive tape or the like. Then, the connector 20 is connected to the outer needle hub 3 (see FIG. 4). With this connection, in the indwelling needle 11 in the first state, the operation member 8 is pressed by the connector main body 201 of the connector 20 and moves in the distal direction, and penetrates the valve body 7. Thereby, the indwelling needle 11 will be in a 2nd state.
  • FIG. 11 is a perspective view showing a valve body included in the indwelling needle assembly according to the second embodiment of the present invention.
  • This embodiment is the same as the first embodiment except that the shape of the groove formed in the valve body is different.
  • each groove 9 ⁇ / b> A has a bent portion 93 ⁇ / b> A in the middle of the extending direction.
  • the bent portion 93A the total length of each groove portion 9A can be extended as compared with the case of a straight line as in the first embodiment, for example, while suppressing the total length of the valve body 7.
  • the blood flowing into each groove 9 ⁇ / b> A can be more reliably absorbed by the hydrophilic polymer layer 10. That is, it is possible to more reliably prevent blood from entering the proximal end side of the valve body 7 through the groove 9A without absorbing the blood by the hydrophilic polymer layer 10 in time.
  • FIG. 12 is a perspective view showing a valve body included in the indwelling needle assembly according to the third embodiment of the present invention.
  • This embodiment is the same as the first embodiment except that the shape of the groove formed in the valve body is different.
  • each groove 9B has a curved shape so as to meander.
  • each groove part 9B by making each groove part 9B into a curved shape, it is possible to extend the entire length of each groove part 9B from, for example, the linear form as in the first embodiment, while suppressing the overall length of the valve body 7. .
  • the blood flowing into each groove part 9B can be more reliably absorbed by the hydrophilic polymer layer 10. That is, it is possible to more reliably prevent blood from entering the proximal end side of the valve body 7 through the groove portion 9B without absorbing blood by the hydrophilic polymer layer 10 in time.
  • FIG. 13 is a perspective view which shows the valve body which the indwelling needle assembly of this invention concerning 4th Embodiment has.
  • This embodiment is the same as the first embodiment except that the shape of the groove formed in the valve body is different.
  • each groove 9C changes along the extending direction.
  • each groove 9 ⁇ / b> C has a constant depth and a width that gradually decreases from the distal end side to the proximal end side of the flow path 31.
  • the groove 9 ⁇ / b> C can be more reliably closed by the swelling of the hydrophilic polymer layer 10.
  • the blood that has flowed through the flow path 31 is gradually absorbed by the hydrophilic polymer layer 10 when it flows into the groove 9C. Therefore, the amount of blood flowing in the groove 9C decreases from the distal end side to the proximal end side of the groove portion 9C. Therefore, by gradually decreasing the width (cross-sectional area) of the groove 9C from the distal end side toward the proximal end side, it is possible to balance the width of the groove portion 9C and the amount of blood flowing therethrough.
  • the region having a smaller amount of blood absorbed by the hydrophilic polymer layer 10 can be filled with the groove 9C with less swelling of the hydrophilic polymer layer 10. Swelling of the molecular layer 10 can block the groove 9C as a whole, and can block blood more reliably.
  • FIG. 14 is a longitudinal cross-sectional view which shows the valve body which the indwelling needle assembly of this invention concerning 5th Embodiment has.
  • This embodiment is the same as the first embodiment except that the shape of the groove formed in the valve body is different.
  • each groove 9 ⁇ / b> D changes along the extending direction.
  • each groove 9 ⁇ / b> D has a constant width, and the depth gradually decreases from the distal end side to the proximal end side of the flow path 31.
  • the groove 9D can be more reliably closed by the swelling of the hydrophilic polymer layer 10.
  • the amount of blood flowing in the groove 9D decreases from the distal end side to the proximal end side of the groove portion 9D. Therefore, by gradually decreasing the depth (cross-sectional area) of the groove 9D from the distal end side toward the proximal end side, it is possible to balance the depth of the groove portion 9D and the amount of blood flowing therethrough.
  • the region having a smaller amount of blood absorbed by the hydrophilic polymer layer 10 can fill the groove 9D with less swelling of the hydrophilic polymer layer 10. Swelling of the molecular layer 10 can block the groove 9D as a whole, and can block blood more reliably.
  • FIG. 15 is a longitudinal sectional view showing an indwelling needle assembly of the present invention according to a sixth embodiment.
  • This embodiment is the same as the first embodiment except that the groove portion formed in the valve body in the above-described embodiment is formed in the outer needle hub.
  • a plurality (eight) grooves 9E are formed on the inner peripheral surface of the outer needle hub 3 so as to open to the flow path 31.
  • the plurality of grooves 9E are formed at equal intervals along the circumferential direction of the outer needle hub 3 as in the above-described embodiment.
  • Each of the plurality of grooves 9E extends along the axial direction of the outer needle hub 3 (longitudinal direction of the flow path 31), and has a distal end side and a proximal end side with respect to the valve body 7 of the flow path 31. Is communicated.
  • each groove 9 ⁇ / b> E has a distal end extending to the distal end side with respect to the valve body 7 of the flow path 31, and a proximal end portion extending to the proximal end side with respect to the valve body 7 of the flow path 31. ing.
  • Each groove 9E has the same function as the grooves 9-9D of the first to fifth embodiments described above. That is, by forming the groove 9E, the air trapped between the blood R flowing into the flow path 31 from the lumen 21 of the outer needle 2 and the valve body 7 is allowed to flow from the valve body 7 through the groove 9E. Can also escape to the proximal side. Therefore, it is possible to perform more reliable priming, that is, it is possible to prevent air from remaining in a region on the tip side of the valve body 7 in the flow path 31. Thereby, safe treatment can be performed.
  • the plurality of groove portions 9E are formed at equal intervals along the circumferential direction of the outer needle hub 3, regardless of the posture of the outer needle hub 3, More reliable priming can be performed.
  • each groove 9E is not particularly limited, but is preferably about 5 ⁇ m to 100 ⁇ m, and more preferably about 50 ⁇ m. As a result, it is possible to configure the groove 9E having a sufficient cross-sectional area for allowing air trapped between the blood R and the valve body 7 to escape to the proximal end side of the valve body 7. Further, the groove 9E can be more reliably closed by the swelling of the hydrophilic polymer layer 10.
  • a hydrophilic polymer layer 10 is formed on the inner surface of each groove 9E.
  • the hydrophilic polymer layer 10 is formed on the bottom surface and both side surfaces of each groove 9E, but is not limited to this, for example, may be formed only on the bottom surface of the groove 9E, It may be formed only on both side surfaces.
  • the indwelling needle assembly of this embodiment has been described above.
  • each groove 9E has a linear shape extending in the axial direction of the outer needle hub 3.
  • the shape of each groove 9E is not limited to this, and for example, the first described above As in the groove portion 9A of the second embodiment, it may have at least one bent portion in the extending direction, or like the groove portion 9B of the third embodiment described above, it is curved to meander. It may be.
  • each groove 9E may have a constant depth and a width gradually decreasing from the distal end side to the proximal end side of the flow path 31 as in the groove portion 9C of the fourth embodiment described above.
  • the width may be constant and the depth may gradually decrease from the distal end side to the proximal end side of the flow path 31.
  • indwelling needle and indwelling needle assembly of this invention were demonstrated about embodiment of illustration, this invention is not limited to this, Each part which comprises an indwelling needle and an indwelling needle assembly is the same. It can be replaced with any structure that can perform its function. Moreover, arbitrary components may be added.
  • the indwelling needle and the indwelling needle assembly of the present invention may be a combination of any two or more configurations (features) of the above embodiments.
  • the indwelling needle assembly (indwelling needle) of the present invention is used by being inserted into a blood vessel, for example, inserted into an abdominal cavity, thoracic cavity, lymphatic vessel, spinal canal, etc. It can also be applied to.
  • the number of grooves is not limited to 8, and may be 1 to 7 or 9 or more.
  • valve body when the valve body is arranged in a posture in which the plate-like portions are orthogonal to each other in the vertical direction, the same effect as in the case of forming a plurality of groove portions can be exhibited even if the number of groove portions is one.
  • the groove portion may be formed in both the valve body and the outer needle hub.
  • the opening / closing part of the valve body is not limited to the illustrated configuration, and may be configured by a duckbill valve, for example.
  • valve body may not be disposed in the middle of the channel, and may be disposed, for example, at the end of the channel.
  • the air trapped between the blood (liquid) flowing into the valve body from the outer needle and the valve body can be released to the other side of the valve body through the groove portion.
  • Blood can be prevented from entering the other side of the valve body. Therefore, bubbles (air) can be prevented from remaining in the flow path on one side of the valve body, and more reliable priming can be performed.
  • it is possible to prevent blood from leaking through the groove. Therefore, it has industrial applicability.

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  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Pulmonology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

La présente invention concerne une aiguille à demeure (11) qui comprend : une aiguille externe creuse (2); un cylindre (3) qui est disposé à l'extrémité de base de l'aiguille externe (2), a un trajet d'écoulement (31) communiquant avec l'intérieur de l'aiguille externe (2), et permet qu'un corps tubulaire soit raccordé au trajet d'écoulement (31) ; un élément de valve (7) qui est disposé à une extrémité ou au milieu du trajet d'écoulement (31) de manière à fermer le trajet d'écoulement (31) et qui a une section d'ouverture-fermeture (71) qui peut être ouverte et fermée ; une rainure (9) pour raccorder la partie du trajet d'écoulement (31) qui est sur un côté de l'élément de valve (7) et la partie du trajet d'écoulement (31) qui est de l'autre côté de l'élément de valve (7) ; et une couche de polymère (10) formée sur la surface interne de la rainure (9). La couche de polymère (10) se déforme ou se transforme par contact avec un liquide qui s'écoule dans la rainure (9), de manière à empêcher le passage du liquide.
PCT/JP2011/066658 2010-08-10 2011-07-22 Aiguille à demeure et ensemble d'aiguille à demeure WO2012020633A1 (fr)

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WO2015133279A1 (fr) * 2014-03-05 2015-09-11 テルモ株式会社 Ensemble de cathéter
US20180093077A1 (en) * 2014-04-18 2018-04-05 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
US10500376B2 (en) 2013-06-07 2019-12-10 Becton, Dickinson And Company IV catheter having external needle shield and internal blood control septum
JP2020146533A (ja) * 2015-10-28 2020-09-17 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 独立流体経路を備える一体型カテーテル
US11571551B2 (en) 2015-10-28 2023-02-07 Becton, Dickinson And Company Ergonomic IV systems and methods
US11786703B2 (en) 2015-10-28 2023-10-17 Becton, Dickinson And Company Closed IV access device with paddle grip needle hub and flash chamber
US11793986B2 (en) 2016-10-05 2023-10-24 Becton, Dickinson And Company Septum housing
EP4275721A1 (fr) * 2022-05-11 2023-11-15 Inductio AG Seringue médicale
US11964117B2 (en) 2015-10-28 2024-04-23 Becton, Dickinson And Company Soft push tabs for catheter adapter
US12023455B2 (en) 2023-02-13 2024-07-02 Becton Dickinson And Company Needle capture safety interlock for catheter

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JP2000279527A (ja) * 1999-03-31 2000-10-10 Terumo Corp 留置針組立体および弁体
JP2001046507A (ja) * 1999-08-04 2001-02-20 Medikit Kk 留置針
JP2002263197A (ja) * 2001-03-12 2002-09-17 Medikit Kk 留置用カテーテル
JP2010522628A (ja) * 2007-03-29 2010-07-08 ベクトン・ディキンソン・アンド・カンパニー 血管アクセスデバイスにおける血液露出防止

Cited By (20)

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US10500376B2 (en) 2013-06-07 2019-12-10 Becton, Dickinson And Company IV catheter having external needle shield and internal blood control septum
US11534581B2 (en) 2013-06-07 2022-12-27 Becton, Dickinson And Company Ported IV catheter having external needle shield and internal blood control septum
JPWO2015133279A1 (ja) * 2014-03-05 2017-04-06 テルモ株式会社 カテーテル組立体
WO2015133279A1 (fr) * 2014-03-05 2015-09-11 テルモ株式会社 Ensemble de cathéter
US11607530B2 (en) 2014-04-18 2023-03-21 Becton, Dickinson And Company Needle capture safety interlock for catheter
US20180093077A1 (en) * 2014-04-18 2018-04-05 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
US10729890B2 (en) 2014-04-18 2020-08-04 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
US10960186B2 (en) * 2014-04-18 2021-03-30 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
JP2022002783A (ja) * 2014-04-18 2022-01-11 ベクトン・ディキンソン・アンド・カンパニーBecton, Dickinson And Company 複数回使用血液制御安全カテーテルアセンブリ
US11931532B2 (en) 2014-04-18 2024-03-19 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
US11565088B2 (en) 2014-04-18 2023-01-31 Becton, Dickinson And Company Multi-use blood control safety catheter assembly
JP2020146533A (ja) * 2015-10-28 2020-09-17 ベクトン・ディキンソン・アンド・カンパニーＢｅｃｔｏｎ， Ｄｉｃｋｉｎｓｏｎ Ａｎｄ Ｃｏｍｐａｎｙ 独立流体経路を備える一体型カテーテル
US11571551B2 (en) 2015-10-28 2023-02-07 Becton, Dickinson And Company Ergonomic IV systems and methods
US11786703B2 (en) 2015-10-28 2023-10-17 Becton, Dickinson And Company Closed IV access device with paddle grip needle hub and flash chamber
JP2022084905A (ja) * 2015-10-28 2022-06-07 ベクトン・ディキンソン・アンド・カンパニー 独立流体経路を備える一体型カテーテル
US11964117B2 (en) 2015-10-28 2024-04-23 Becton, Dickinson And Company Soft push tabs for catheter adapter
US11793986B2 (en) 2016-10-05 2023-10-24 Becton, Dickinson And Company Septum housing
EP4275721A1 (fr) * 2022-05-11 2023-11-15 Inductio AG Seringue médicale
WO2023217973A1 (fr) * 2022-05-11 2023-11-16 Inductio Ag Seringue médicale
US12023455B2 (en) 2023-02-13 2024-07-02 Becton Dickinson And Company Needle capture safety interlock for catheter

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