WO2012019299A9 - Composés inhibiteurs de l'hépatite c - Google Patents
Composés inhibiteurs de l'hépatite c Download PDFInfo
- Publication number
- WO2012019299A9 WO2012019299A9 PCT/CA2011/050484 CA2011050484W WO2012019299A9 WO 2012019299 A9 WO2012019299 A9 WO 2012019299A9 CA 2011050484 W CA2011050484 W CA 2011050484W WO 2012019299 A9 WO2012019299 A9 WO 2012019299A9
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- hepatitis
- inhibitor compounds
- formula
- compounds
- hcv
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/503—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses
- C12N9/506—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from viruses derived from RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
La présente invention concerne des composés de formule (I) (Formule (I)) dans laquelle R1, R2, R3, R4 et n sont tels que définis dans la description, qui sont utiles en tant qu'inhibiteurs de la protéase NS3 du VHC pour le traitement de l'infection par le virus de l'hépatite C.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37257510P | 2010-08-11 | 2010-08-11 | |
US61/372,575 | 2010-08-11 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2012019299A1 WO2012019299A1 (fr) | 2012-02-16 |
WO2012019299A9 true WO2012019299A9 (fr) | 2012-10-26 |
Family
ID=45567240
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/CA2011/050484 WO2012019299A1 (fr) | 2010-08-11 | 2011-08-10 | Composés inhibiteurs de l'hépatite c |
Country Status (1)
Country | Link |
---|---|
WO (1) | WO2012019299A1 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8957203B2 (en) | 2011-05-05 | 2015-02-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
UA119315C2 (uk) | 2012-07-03 | 2019-06-10 | Гіліад Фармассет Елелсі | Інгібітори вірусу гепатиту с |
MX360452B (es) | 2012-10-19 | 2018-11-01 | Bristol Myers Squibb Co | Inhibidores del virus de la hepatitis c. |
WO2014071007A1 (fr) * | 2012-11-02 | 2014-05-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
US9643999B2 (en) | 2012-11-02 | 2017-05-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9598433B2 (en) | 2012-11-02 | 2017-03-21 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2014070974A1 (fr) | 2012-11-05 | 2014-05-08 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
WO2014137869A1 (fr) | 2013-03-07 | 2014-09-12 | Bristol-Myers Squibb Company | Inhibiteurs du virus de l'hépatite c |
JP6511432B2 (ja) | 2013-03-15 | 2019-05-15 | ギリアード サイエンシーズ, インコーポレイテッド | C型肝炎ウイルスの大環状二環式阻害剤 |
CN109354600B (zh) * | 2018-11-29 | 2021-08-10 | 浙江海洋大学 | 一种牛磺酸修饰的新型阿拉斯加鳕鱼多功能肽的制备方法 |
IL294046A (en) | 2019-12-23 | 2022-08-01 | Synthorx Inc | Methods for the preparation of n6-((2-azidoethoxy)carbonyl)lysine |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7741281B2 (en) * | 2005-11-03 | 2010-06-22 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
WO2010088394A1 (fr) * | 2009-01-30 | 2010-08-05 | Glaxosmithkline Llc | Composés |
-
2011
- 2011-08-10 WO PCT/CA2011/050484 patent/WO2012019299A1/fr active Application Filing
Also Published As
Publication number | Publication date |
---|---|
WO2012019299A1 (fr) | 2012-02-16 |
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