WO2012013020A8 - 一种抗疲劳的组合物及其制剂和应用 - Google Patents

一种抗疲劳的组合物及其制剂和应用 Download PDF

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Publication number
WO2012013020A8
WO2012013020A8 PCT/CN2011/001233 CN2011001233W WO2012013020A8 WO 2012013020 A8 WO2012013020 A8 WO 2012013020A8 CN 2011001233 W CN2011001233 W CN 2011001233W WO 2012013020 A8 WO2012013020 A8 WO 2012013020A8
Authority
WO
WIPO (PCT)
Prior art keywords
protopanoxadiol
formulation
lycium barbarum
fatigue
barbarum polysaccharide
Prior art date
Application number
PCT/CN2011/001233
Other languages
English (en)
French (fr)
Other versions
WO2012013020A1 (zh
Inventor
许长江
贾韦国
俞春莺
张文静
韩祺园
葛强
汪沁琳
杨子荣
Original Assignee
上海中药创新研究中心
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 上海中药创新研究中心 filed Critical 上海中药创新研究中心
Priority to JP2013520948A priority Critical patent/JP5797268B2/ja
Priority to RU2013106172/15A priority patent/RU2559784C2/ru
Priority to KR1020137004752A priority patent/KR101735151B1/ko
Priority to EP11811722.5A priority patent/EP2599490B1/en
Priority to US13/812,485 priority patent/US20130123212A1/en
Publication of WO2012013020A1 publication Critical patent/WO2012013020A1/zh
Publication of WO2012013020A8 publication Critical patent/WO2012013020A8/zh
Priority to HK13110258.1A priority patent/HK1182934A1/zh
Priority to US14/535,257 priority patent/US9603866B2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00—Function of food ingredients
    • A23V2200/30—Foods, ingredients or supplements having a functional effect on health
    • A23V2200/31—Foods, ingredients or supplements having a functional effect on health having an effect on comfort perception and well-being

Abstract

本发明提供一种抗疲劳的组合物，该组合物由20(S)-原人参二醇和枸杞多糖组成。实验证明，该组合物表现出显著的抗疲劳作用。与单用枸杞多糖或20(S)-原人参二醇的效果相比，20(S)-原人参二醇和枸杞多糖的联合具有明显的协同增效作用。
PCT/CN2011/001233 2010-07-27 2011-07-27 一种抗疲劳的组合物及其制剂和应用 WO2012013020A1 (zh)

Priority Applications (7)

Application Number Priority Date Filing Date Title
JP2013520948A JP5797268B2 (ja) 2010-07-27 2011-07-27 抗疲労組成物、その製剤及び応用
RU2013106172/15A RU2559784C2 (ru) 2010-07-27 2011-07-27 Композиция для снятия усталости, состав и их применение
KR1020137004752A KR101735151B1 (ko) 2010-07-27 2011-07-27 항피로 조성물, 그의 제형 및 용도
EP11811722.5A EP2599490B1 (en) 2010-07-27 2011-07-27 Anti-fatigue composition, formulation and use thereof
US13/812,485 US20130123212A1 (en) 2010-07-27 2011-07-27 Anti-fatigue composition, formulation and use thereof
HK13110258.1A HK1182934A1 (zh) 2010-07-27 2013-09-03 種抗疲勞的組合物及其製劑和應用
US14/535,257 US9603866B2 (en) 2010-07-27 2014-11-06 Anti-fatigue composition, formulation and use thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201010237955.0 2010-07-27
CN2010102379550A CN101890040B (zh) 2010-07-27 2010-07-27 一种具有抗疲劳作用的组合物及其应用

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/812,485 A-371-Of-International US20130123212A1 (en) 2010-07-27 2011-07-27 Anti-fatigue composition, formulation and use thereof
US14/535,257 Division US9603866B2 (en) 2010-07-27 2014-11-06 Anti-fatigue composition, formulation and use thereof

Publications (2)

Publication Number Publication Date
WO2012013020A1 WO2012013020A1 (zh) 2012-02-02
WO2012013020A8 true WO2012013020A8 (zh) 2013-02-21

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CN2011/001233 WO2012013020A1 (zh) 2010-07-27 2011-07-27 一种抗疲劳的组合物及其制剂和应用

Country Status (8)

Country Link
US (2) US20130123212A1 (zh)
EP (1) EP2599490B1 (zh)
JP (1) JP5797268B2 (zh)
KR (1) KR101735151B1 (zh)
CN (1) CN101890040B (zh)
HK (1) HK1182934A1 (zh)
RU (1) RU2559784C2 (zh)
WO (1) WO2012013020A1 (zh)

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CN101890040B (zh) 2010-07-27 2011-12-21 上海中药创新研究中心 一种具有抗疲劳作用的组合物及其应用
CN102697047B (zh) * 2012-06-11 2013-11-06 宁夏红中宁枸杞制品有限公司 一种枸杞口服液的制备方法
CN109105702A (zh) * 2018-08-30 2019-01-01 泓博元生命科技（深圳）有限公司 一种含有nadh的组合物、应用及能量补充剂的制备方法
CN109170907A (zh) * 2018-08-30 2019-01-11 泓博元生命科技（深圳）有限公司 一种含有nmn的组合物、应用及运动饮料的制备方法
CN109997946A (zh) * 2019-02-20 2019-07-12 山东佰诺生物科技有限公司 一种复合压片糖果及其制备方法
KR101988959B1 (ko) 2019-05-13 2019-06-14 주식회사 한미양행 굼벵이 효소처리물을 함유하는 스트레스 완화용 또는 항피로용 조성물
CN111529539A (zh) * 2020-04-29 2020-08-14 海南亚洲制药股份有限公司 一种原人参二醇在制备药物中的用途
CN112451655B (zh) * 2020-12-10 2022-12-27 中国科学院兰州化学物理研究所 一种抗疲劳组合物及其应用
CN112656870B (zh) * 2021-01-20 2022-07-05 森隆药业有限公司 一种抗疲劳中药组合物及其制备方法和用途
CN113041225B (zh) * 2021-03-26 2022-08-30 那生桑 含糖分类蒙药粉配方颗粒及其制备方法
KR20220151393A (ko) 2021-05-06 2022-11-15 도영복 인삼을 함유하는 스트레스 완화용 건강기능성 차 조성물
CN113633657B (zh) * 2021-05-08 2024-03-01 中国人民解放军海军军医大学 一种提高机体抗疲劳、耐缺氧、耐热和耐寒能力的药物组合物及其应用

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Also Published As

Publication number Publication date
JP2013532666A (ja) 2013-08-19
EP2599490A1 (en) 2013-06-05
CN101890040B (zh) 2011-12-21
US9603866B2 (en) 2017-03-28
KR20130131303A (ko) 2013-12-03
US20150065452A1 (en) 2015-03-05
EP2599490B1 (en) 2016-05-04
KR101735151B1 (ko) 2017-05-24
US20130123212A1 (en) 2013-05-16
WO2012013020A1 (zh) 2012-02-02
RU2013106172A (ru) 2014-09-10
RU2559784C2 (ru) 2015-08-10
HK1182934A1 (zh) 2013-12-13
CN101890040A (zh) 2010-11-24
EP2599490A4 (en) 2014-01-08
JP5797268B2 (ja) 2015-10-21

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