WO2011147425A1 - Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique - Google Patents

Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique Download PDF

Info

Publication number
WO2011147425A1
WO2011147425A1 PCT/EE2011/000005 EE2011000005W WO2011147425A1 WO 2011147425 A1 WO2011147425 A1 WO 2011147425A1 EE 2011000005 W EE2011000005 W EE 2011000005W WO 2011147425 A1 WO2011147425 A1 WO 2011147425A1
Authority
WO
WIPO (PCT)
Prior art keywords
concentration
biological fluid
substances
dialysis
sample
Prior art date
Application number
PCT/EE2011/000005
Other languages
English (en)
Inventor
Ivo Fridolin
Fredrik Uhlin
Jana Jerotskaja
Kai Lauri
Merike Luman
Original Assignee
Tallinn University Of Technology
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EEP201000049A external-priority patent/EE05674B1/xx
Priority claimed from EEP201100002A external-priority patent/EE05637B1/xx
Application filed by Tallinn University Of Technology filed Critical Tallinn University Of Technology
Priority to EP20110741089 priority Critical patent/EP2577270A1/fr
Publication of WO2011147425A1 publication Critical patent/WO2011147425A1/fr

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84Systems specially adapted for particular applications
    • G01N21/85Investigating moving fluids or granular solids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03Cuvette constructions
    • G01N21/05Flow-through cuvettes

Abstract

L'invention concerne un procédé et un dispositif de surveillance de l'élimination de solutés de rétention urémique difficilement ou facilement diffusibles au cours de la dialyse et de mesure des concentrations desdites substances dans un liquide biologique et, plus spécifiquement, dans le dialysat sortant, afin d'estimer la dose de dialyse sur des patients en cours de dialyse. Des mesures sont réalisées de manière optique à l'aide du spectre du liquide biologique et un algorithme de calcul de concentrations contenant la fonction de transformation, comprenant un ensemble unique de composantes du spectre optique à certaines longueurs d'onde, afin de déterminer la concentration des substances dans des échantillons in vitro ou des liquides s'écoulant, en direct. Le procédé et le dispositif déterminent la concentration des substances in vitro ou en direct à l'aide d'une cuve de mesure adaptée pour des mesures spécifiées. Ceci permet la surveillance quantitative des concentrations des substances dans un liquide biologique et le calcul de la dose de dialyse pour des solutés de rétention urémique difficilement ou facilement diffusibles, adaptée pour surveiller automatiquement et rapidement la qualité de la dialyse administrée aux patients atteints d'une maladie rénale en stade terminal.
PCT/EE2011/000005 2010-05-27 2011-05-27 Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique WO2011147425A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
EP20110741089 EP2577270A1 (fr) 2010-05-27 2011-05-27 Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EEP201000049 2010-05-27
EEP201000049A EE05674B1 (et) 2010-05-27 2010-05-27 Seade ja meetod v„ikese molekulmassiga veeslahustuvate ainete uurea, kreatiniini ja kusihappe kontsentratsiooni kvantitatiivseks m„„ramiseks
EEP201100002 2011-01-14
EEP201100002A EE05637B1 (et) 2011-01-14 2011-01-14 Meetod ja seade raskesti difundeeruvate ureemiliste retentsiooni soluutide kontsentratsioonide m„„ramiseks bioloogilises vedelikus ja nende eemaldamise monitooringuks UV-neelduvusega neeruasendusravil

Publications (1)

Publication Number Publication Date
WO2011147425A1 true WO2011147425A1 (fr) 2011-12-01

Family

ID=44484872

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EE2011/000005 WO2011147425A1 (fr) 2010-05-27 2011-05-27 Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique

Country Status (2)

Country Link
EP (1) EP2577270A1 (fr)
WO (1) WO2011147425A1 (fr)

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012152514A1 (fr) 2011-05-11 2012-11-15 Ldiamon As Procédé et dispositif de dosage pour déterminer le taux d'acide urique et de créatinine
RU2499557C1 (ru) * 2012-10-08 2013-11-27 Арсений Юрьевич Шитов Способ оценки волюморегулирующей функции почек в условиях повышенного давления газовой среды
DE102012112790A1 (de) * 2012-12-20 2014-06-26 B. Braun Avitum Ag Verfahren und Vorrichtung zur Bestimmung von Abfallprodukten wie Indoxyl Sulfate in der Dialyse
RU2525738C1 (ru) * 2013-04-09 2014-08-20 Арсений Юрьевич Шитов Способ оценки кальцийуретической функции почек человека в условиях повышенного давления газовой среды
DE102014106489A1 (de) * 2014-05-08 2015-11-12 B. Braun Avitum Ag Vorrichtung und Vorrichtungs-Steuerungsverfahren zur quantitativen Konzentrationsbestimmung ausgewählter aus einem Patientenkörper ausgefilterter Substanzen in einer Flüssigkeit
CN105823746A (zh) * 2016-05-23 2016-08-03 青岛海大生物集团有限公司 一种水溶肥料中壳聚糖含量的检测方法
RU2709469C1 (ru) * 2019-10-03 2019-12-18 Арсений Юрьевич Шитов Способ определения степени индивидуальной устойчивости водолазов к токсическому действию азота по показателям функций почек
RU2709477C1 (ru) * 2019-10-03 2019-12-18 Арсений Юрьевич Шитов Способ определения степени индивидуальной устойчивости водолазов к токсическому действию кислорода по показателям функций почек
WO2020182395A1 (fr) 2019-03-11 2020-09-17 Gambro Lundia Ab Estimation du taux de génération d'une substance chez des patients sous dialyse
CN112805044A (zh) * 2018-08-23 2021-05-14 尼普洛株式会社 细胞外液量计算装置和细胞外液量计算方法
US11255844B2 (en) 2018-03-06 2022-02-22 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
WO2022172059A1 (fr) * 2021-02-12 2022-08-18 AusMed Global Limited Système et procédé de détermination d'une concentration d'un analyte dans un fluide

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357960A (en) 1988-10-07 1994-10-25 Siemens Aktiengesellschaft Method and apparatus for the quantitative determination of optically active substances
WO1998019592A1 (fr) 1996-11-01 1998-05-14 Rio Grande Medical Technologies, Inc. Procede et dispositif de surveillance de dialyse
US5886347A (en) 1994-07-13 1999-03-23 Horiba, Ltd. Analytical method for multi-component aqueous solutions and apparatus for the same
WO1999062574A1 (fr) 1998-06-04 1999-12-09 Althin Medical Ab Procede permettant de determiner la quantite de dechets dans le liquide de dialyse au cours d'une dialyse
US6121050A (en) 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
RU2212029C1 (ru) 2001-12-03 2003-09-10 Общество с ограниченной ответственностью "Клиника экстракорпоральной гемокоррекции" Способ анализа жидкой биологической среды в процессе мониторинга
US20030231294A1 (en) * 2002-06-12 2003-12-18 Ramesh Wariar Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance
US20070023334A1 (en) 2003-09-23 2007-02-01 Gambro Lundia Ab Apparatus, a system and a method relating to hemodialysis, hemodiafiltration, hemofiltration or peritoneal dialysis
US7372039B2 (en) 2005-12-20 2008-05-13 Ecolab Inc. Near UV absorption spectrometer and method for using the same
EP1070954B1 (fr) 1999-07-20 2008-11-05 Secomam Procédé et dispositif pour l'analyse d'un échantillon liquide.
US20080304048A1 (en) 2005-11-29 2008-12-11 Ge Healthcare Bio-Sciences Ab Methods and Apparatus For Measuring the Concentration of a Substance in a Solution
EP2005982A1 (fr) 2007-06-20 2008-12-24 B. Braun Avitum AG Procédé pour déterminer le rapport de réduction ou la valeur Kt/V d'un traitement de remplacement de rein et appareil pour la mise en place du procédé
WO2009071102A1 (fr) 2007-12-04 2009-06-11 Tallinn University Of Technology Procédé et dispositif optique pour mesurer des concentrations de substances dans des fluides biologiques
US20110040494A1 (en) 2007-11-26 2011-02-17 Kevin Anthony Foster Method and apparatus for absorption spectra analysis

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010034626A1 (de) * 2010-08-17 2012-02-23 B. Braun Avitum Ag Vorrichtung zur extrakorporalen Blutbehandlung

Patent Citations (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5357960A (en) 1988-10-07 1994-10-25 Siemens Aktiengesellschaft Method and apparatus for the quantitative determination of optically active substances
US5886347A (en) 1994-07-13 1999-03-23 Horiba, Ltd. Analytical method for multi-component aqueous solutions and apparatus for the same
WO1998019592A1 (fr) 1996-11-01 1998-05-14 Rio Grande Medical Technologies, Inc. Procede et dispositif de surveillance de dialyse
US6121050A (en) 1997-08-29 2000-09-19 Han; Chi-Neng Arthur Analyte detection systems
WO1999062574A1 (fr) 1998-06-04 1999-12-09 Althin Medical Ab Procede permettant de determiner la quantite de dechets dans le liquide de dialyse au cours d'une dialyse
US6666840B1 (en) 1998-06-04 2003-12-23 Althin Medical Ab Method for determining waste products in the dialysis liquid in dialysis treatment
EP1070954B1 (fr) 1999-07-20 2008-11-05 Secomam Procédé et dispositif pour l'analyse d'un échantillon liquide.
RU2212029C1 (ru) 2001-12-03 2003-09-10 Общество с ограниченной ответственностью "Клиника экстракорпоральной гемокоррекции" Способ анализа жидкой биологической среды в процессе мониторинга
US20030231294A1 (en) * 2002-06-12 2003-12-18 Ramesh Wariar Optical sensor and method for measuring concentration of a chemical constituent using its intrinsic optical absorbance
US20070023334A1 (en) 2003-09-23 2007-02-01 Gambro Lundia Ab Apparatus, a system and a method relating to hemodialysis, hemodiafiltration, hemofiltration or peritoneal dialysis
US20080304048A1 (en) 2005-11-29 2008-12-11 Ge Healthcare Bio-Sciences Ab Methods and Apparatus For Measuring the Concentration of a Substance in a Solution
US7372039B2 (en) 2005-12-20 2008-05-13 Ecolab Inc. Near UV absorption spectrometer and method for using the same
EP2005982A1 (fr) 2007-06-20 2008-12-24 B. Braun Avitum AG Procédé pour déterminer le rapport de réduction ou la valeur Kt/V d'un traitement de remplacement de rein et appareil pour la mise en place du procédé
US20110040494A1 (en) 2007-11-26 2011-02-17 Kevin Anthony Foster Method and apparatus for absorption spectra analysis
WO2009071102A1 (fr) 2007-12-04 2009-06-11 Tallinn University Of Technology Procédé et dispositif optique pour mesurer des concentrations de substances dans des fluides biologiques

Non-Patent Citations (25)

* Cited by examiner, † Cited by third party
Title
ARTISS, J. D., R. E. KARCHER ET AL.: "Application and evaluation of a new cold- stable kinetic Jaffe reagent to the Hitachi 747 for the determination of serum creatinine", MICROCHEMICAL JOURNAL, vol. 65, no. 3, 2000, pages 277 - 282
CANO F ET AL: "Kt/V and nPNA in pediatric peritoneal dialysis: a clinical or a mathematical association?", PEDIATRIC NEPHROLOGY ; JOURNAL OF THE INTERNATIONAL PEDIATRIC NEPHROLOGY ASSOCIATION, SPRINGER, BERLIN, DE, vol. 21, no. 1, 1 January 2006 (2006-01-01), pages 114 - 118, XP019347992, ISSN: 1432-198X, DOI: 10.1007/S00467-005-2048-9 *
CASINO FG, PEDRINI LA, SANTORO A, MANDOLFO S, DAVID S, DE CRISTOFARO V, TEATINI U, LOMONTE C, LOPEZ T: "A simple approach for assessing equilibrated Kt/V beta 2-M on a routine basis", NEPHROL DIAL TRANSPLANT., vol. 25, no. 9, September 2010 (2010-09-01), pages 3038 - 44
CHEUNG AK, GREENE T, LEYPOLDT JK, YAN G, ALLON M, DELMEZ J, LEVEY AS, LEVIN NW, ROCCO MV, SCHULMAN G: "HEMO Study Group. Association between serum 2-microglobulin level and infectious mortality in hemodialysis patients", CLIN J AM SOC NEPHROL., vol. 3, no. 1, January 2008 (2008-01-01), pages 69 - 77
CHEUNG AK, ROCCO MV, YAN G, LEYPOLDT JK, LEVIN NW, GREENE T, AGODOA L, BAILEY J, BECK GJ, CLARK W: "Serum -2 microglobulin levels predict mortality in dialysis patients: results of the HEMO Study", J AM SOC NEPHROL, vol. 17, no. 2, February 2006 (2006-02-01), pages 546 - 55
DE SMET R, GLORIEUX G, HSU C, VANHOLDER R: "P-cresol and uric acid: two old uremic toxins revisited", KIDNEY INT, vol. 62, November 1997 (1997-11-01), pages 8 - 11
DHONDT, A. W., R. C. VANHOLDER ET AL.: "Studies on dialysate mixing in the Genius (R) single-pass batch system for hemodialysis therapy", KIDNEY INTERNATIONAL, vol. 63, no. 4, 2003, pages 1540 - 1547
DRUEKE TB, MASSY ZA: "Beta2-microglobulin", SEMIN DIAL., vol. 22, no. 4, July 2009 (2009-07-01), pages 378 - 80
ERA-EDTA: "EBPG - European Best Practice Guidelines: SECTION II. Haemodialysis adequacy 11.2 Haemodialysis dose quantification: middle molecules (MM", NEPHROLOGY DIALYSIS TRANSPLANTATION, vol. 17, no. 7, 2002, pages 21 - 23
FEIG DI, KANG DH, JOHNSON RJ: "Uric acid and cardiovascular risk", N ENGL J MED., vol. 359, no. 17, 23 October 2008 (2008-10-23), pages 1811 - 21
FRIDOLIN I ET AL: "ON-LINE MONITORING OF SOLUTES IN DIALYSATE USING WAVELENGTH-DEPENDENT ABSORPTION OF ULTRAVIOLET RADIATION", MEDICAL AND BIOLOGICAL ENGINEERING AND COMPUTING, SPRINGER, HEILDELBERG, DE, vol. 41, no. 3, 1 May 2003 (2003-05-01), pages 263 - 270, XP001047249, ISSN: 0140-0118, DOI: 10.1007/BF02348430 *
FRIDOLIN, I., M. MAGNUSSON ET AL.: "On-line monitoring of solutes in dialysate using absorption of ultraviolet radiation: technique description", THE INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS, vol. 25, no. 8, 2002, pages 748 - 761, XP008101248
HAYDEN MR, TYAGI SC: "Uric acid: A new look at an old risk marker for cardiovascular disease, metabolic syndrome, and type 2 diabetes mellitus: The urate redox shuttle (review", NUTR METAB (LOND, vol. 1, no. 1, 19 October 2004 (2004-10-19), pages 10, XP021010947, DOI: doi:10.1186/1743-7075-1-10
HOIEGGEN A, ALDERMAN MH, KJELDSEN SE ET AL.: "LIFE Study Group. The impact of serum uric acid on cardiovascular outcomes in the LIFE study", KIDNEY INT., vol. 65, no. 3, March 2004 (2004-03-01), pages 1041 - 9
LUMAN, M., J. JEROTSKAJA ET AL.: "Dialysis dose and nutrition assessment by optical on-line dialysis adequacy monitor", CLINICAL NEPHROLOGY, vol. 72, no. 4, 2009, pages 303 - 311, XP009151764
NAKAGAWA T, MAZZALI M, KANG D-H, SANCHEZ-LOZADA LG, HERRERA-ACOSTA J, JOHNSON RJ: "Uric acid- a uremic toxin?", BLOOD PURIF., vol. 24, 2006, pages 67 - 70
NAVANEETHAN SD, BEDDHU S: "Associations of serum uric acid with cardiovascular events and mortality in moderate chronic kidney disease", NEPHROL DIAL TRANSPLANT., vol. 24, no. 4, April 2009 (2009-04-01), pages 1260 - 66
PERLSTEIN T S, GUMIENIAK 0, HOPKINS P, MURPHEY L, BROWN N, WILLIAMS G: "Uric acid and the state of intrarenal renin-angiotensin system in humans", KIDNEY INT, vol. 66, 2004, pages 1465 - 1470
See also references of EP2577270A1 *
UHLIN, F., I. FRIDOLIN ET AL.: "Estimating total urea removal and protein catabolic rate by monitoring UV absorbance in spent dialysate", NEPHROL DIAL TRANSPLANT., 20 November 2005 (2005-11-20), pages 2458 - 2464, XP001167226, DOI: doi:10.1093/NDT/GFI026
UHLIN, F., I. FRIDOLIN ET AL.: "Estimation of delivered dialysis dose by on-line monitoring of the UV-absorbance in the spent dialysate", AMERICAN JOURNAL OF KIDNEY DISEASES, vol. 41, 5 May 2003 (2003-05-05), pages 1026 - 1036, XP028836390, DOI: doi:10.1016/S0272-6386(03)00200-2
UHLIN, F., L. G. LINDBERG ET AL.: "Total Removed Uric Acid During Dialysis Estimated by On-line Ultra Violet Absorbance in the Spent Dialysate", 3RD EUROPEAN MEDICAL & BIOLOGICAL ENGINEERING CONFERENCE, EMBEC'05, PRAGUE, CZECH REPUBLIC, IFMBE PROCEEDINGS, vol. 11, 2005, pages 6
VANHOLDER, R., R. DE SMET ET AL.: "Review on uremic toxins: classification, concentration, and interindividual variability", KIDNEY INTERNATIONAL, vol. 63, no. 5, 2003, pages 1934 - 1943, XP009088717, DOI: doi:10.1046/j.1523-1755.2003.00924.x
VIAZZI F, LEONCINI G, RATTO E, PONTREMOLI R: "Serum uric acid as a risk factor for cardiovascular and renal disease: an old controversy revived", J CLIN HYPERTENS, vol. 8, no. 7, 2006, pages 510 - 518
YAVUZ, A. ET AL.: "Uremic toxins: a new focus on an old subject", SEMIN DIAL, vol. 18, no. 3, May 2005 (2005-05-01), pages 203 - 11

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012152514A1 (fr) 2011-05-11 2012-11-15 Ldiamon As Procédé et dispositif de dosage pour déterminer le taux d'acide urique et de créatinine
RU2499557C1 (ru) * 2012-10-08 2013-11-27 Арсений Юрьевич Шитов Способ оценки волюморегулирующей функции почек в условиях повышенного давления газовой среды
DE102012112790A1 (de) * 2012-12-20 2014-06-26 B. Braun Avitum Ag Verfahren und Vorrichtung zur Bestimmung von Abfallprodukten wie Indoxyl Sulfate in der Dialyse
RU2525738C1 (ru) * 2013-04-09 2014-08-20 Арсений Юрьевич Шитов Способ оценки кальцийуретической функции почек человека в условиях повышенного давления газовой среды
US9423338B2 (en) 2014-05-08 2016-08-23 B. Braun Avitum Ag Apparatus and apparatus control method for the quantitative concentration determination of selected substances filtered out of a patient's body in a fluid
DE102014106489A1 (de) * 2014-05-08 2015-11-12 B. Braun Avitum Ag Vorrichtung und Vorrichtungs-Steuerungsverfahren zur quantitativen Konzentrationsbestimmung ausgewählter aus einem Patientenkörper ausgefilterter Substanzen in einer Flüssigkeit
CN105823746A (zh) * 2016-05-23 2016-08-03 青岛海大生物集团有限公司 一种水溶肥料中壳聚糖含量的检测方法
CN105823746B (zh) * 2016-05-23 2018-08-17 青岛海大生物集团有限公司 一种水溶肥料中壳聚糖含量的检测方法
US11255844B2 (en) 2018-03-06 2022-02-22 Fresenius Medical Care Holdings, Inc. Peritoneal dialysis systems and related methods
CN112805044A (zh) * 2018-08-23 2021-05-14 尼普洛株式会社 细胞外液量计算装置和细胞外液量计算方法
WO2020182395A1 (fr) 2019-03-11 2020-09-17 Gambro Lundia Ab Estimation du taux de génération d'une substance chez des patients sous dialyse
RU2709469C1 (ru) * 2019-10-03 2019-12-18 Арсений Юрьевич Шитов Способ определения степени индивидуальной устойчивости водолазов к токсическому действию азота по показателям функций почек
RU2709477C1 (ru) * 2019-10-03 2019-12-18 Арсений Юрьевич Шитов Способ определения степени индивидуальной устойчивости водолазов к токсическому действию кислорода по показателям функций почек
WO2022172059A1 (fr) * 2021-02-12 2022-08-18 AusMed Global Limited Système et procédé de détermination d'une concentration d'un analyte dans un fluide

Also Published As

Publication number Publication date
EP2577270A1 (fr) 2013-04-10

Similar Documents

Publication Publication Date Title
EP2577270A1 (fr) Procédé et dispositif de mesure et de surveillance des concentrations de substances dans un liquide biologique
US20230243752A1 (en) System and method for monitoring the health of dialysis patients
JP4515786B2 (ja) 全血中の分析対象物の計測に対するヘマトクリットの影響を減らす方法ならびに当該方法で有用な試験キット及び試験用品
AU2012241983B2 (en) Method and apparatus for monitoring a treatment of a patient, preferably for monitoring hemodialysis, hemodiafiltration, and/or peritoneal dialysis
US9423338B2 (en) Apparatus and apparatus control method for the quantitative concentration determination of selected substances filtered out of a patient's body in a fluid
US8125623B2 (en) Correlation technique for analysis of clinical condition
EP2861127A1 (fr) Procédé et dispositif de surveillance d'un traitement extracorporel du sang d'un patient
Jerotskaja et al. Optical online monitoring of uric acid removal during dialysis
Roth et al. Infrared spectroscopy in hemodialysis: reagent-free monitoring of patient detoxification by infrared spectroscopy
US9103789B2 (en) Method and device for determining content of the middle and protein bound uremic toxins in a biological fluid
WO2009071102A1 (fr) Procédé et dispositif optique pour mesurer des concentrations de substances dans des fluides biologiques
Senftleber et al. Reversed-phase liquid-chromatographic analysis of hemodialysate from uremic patients.
Fridolin et al. On-line monitoring of solutes in dialysate using wavelength-dependent absorption of ultraviolet radiation
Lin et al. Optoelectronic online monitoring system for hemodialysis and its data analysis
Lauri et al. HPLC study of uremic fluids related to optical dialysis adequacy monitoring
US20240102930A1 (en) Multiparametric Optical Method and Device for determining Uremic Solutes, including Uremix Toxins, in Biological Fluids
Uhlin et al. Optical monitoring of dialysis dose
Tomson et al. Development of a method for optical monitoring of creatinine in the spent dialysate
Kondepati et al. Infrared transmission spectrometry for the determination of urea in microliter sample volumes of blood plasma dialysates
Lauri et al. Optical dialysis adequacy monitoring: small uremic toxins and contribution to UV-absorbance studied by HPLC
Holmar et al. Beta2-microglobulin measurements in the spent dialysate using fluorescence spectra
LAURI Elimination of Uremic Toxins during Dialysis assessed with the Optical and Analytical Methods
Jerotskaja et al. Improved optical method for measuring concentration of uric acid removed during dialysis
Lagali et al. Hemodialysis monitoring in whole blood using transmission and diffuse reflection spectroscopy:<? xpp qa?> a pilot study
Lauri et al. Optical dialysis adequacy sensor: contribution of chromophores to the ultra violet absorbance in the spent dialysate

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11741089

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

WWE Wipo information: entry into national phase

Ref document number: 2011741089

Country of ref document: EP