WO2011137220A1 - Antagonistes à petite molécule du neuropeptide s destinés au traitement d'une toxicomanie ou de troubles de l'humeur, de l'anxiété et du sommeil - Google Patents

Antagonistes à petite molécule du neuropeptide s destinés au traitement d'une toxicomanie ou de troubles de l'humeur, de l'anxiété et du sommeil Download PDF

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Publication number
WO2011137220A1
WO2011137220A1 PCT/US2011/034276 US2011034276W WO2011137220A1 WO 2011137220 A1 WO2011137220 A1 WO 2011137220A1 US 2011034276 W US2011034276 W US 2011034276W WO 2011137220 A1 WO2011137220 A1 WO 2011137220A1
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
aryl
group
compound
stereoisomer
Prior art date
Application number
PCT/US2011/034276
Other languages
English (en)
Inventor
Juan J. Marugan
Samarjit Patnaik
Markus A. Heilig
Noel T. Southall
Wei Zheng
Original Assignee
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The United States Of America, As Represented By The Secretary, Department Of Health And Human Services filed Critical The United States Of America, As Represented By The Secretary, Department Of Health And Human Services
Publication of WO2011137220A1 publication Critical patent/WO2011137220A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C07F9/5728—Five-membered rings condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C07F9/65068—Five-membered rings having the nitrogen atoms in positions 1 and 3 condensed with carbocyclic rings or carbocyclic ring systems

Abstract

La présente invention concerne des composés de formule générale I : dans laquelle R1, R2, R3, X et Y sont décrits dans ce document, ainsi que leurs sels pharmaceutiquement acceptables, solvates et stéréo-isomères. L'invention concerne également des compositions pharmaceutiques contenant ces composés ainsi que des méthodes d'utilisation et de traitement de troubles neuropsychiatriques y compris la douleur, des troubles du sommeil, de l'humeur, de l'anxiété, de l'alimentation et de toxicomanie.
PCT/US2011/034276 2010-04-28 2011-04-28 Antagonistes à petite molécule du neuropeptide s destinés au traitement d'une toxicomanie ou de troubles de l'humeur, de l'anxiété et du sommeil WO2011137220A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32890010P 2010-04-28 2010-04-28
US61/328,900 2010-04-28

Publications (1)

Publication Number Publication Date
WO2011137220A1 true WO2011137220A1 (fr) 2011-11-03

Family

ID=44070611

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2011/034276 WO2011137220A1 (fr) 2010-04-28 2011-04-28 Antagonistes à petite molécule du neuropeptide s destinés au traitement d'une toxicomanie ou de troubles de l'humeur, de l'anxiété et du sommeil

Country Status (1)

Country Link
WO (1) WO2011137220A1 (fr)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
WO2002044120A1 (fr) * 2000-11-29 2002-06-06 Karo Bio Ab Composes ayant une action sur le recepteur glucocorticoide iii
WO2004067529A1 (fr) * 2003-01-22 2004-08-12 Eli Lilly And Company Modulateurs a base de derives indoliques des recepteurs nucleaires des hormones steroides
WO2009156072A1 (fr) * 2008-06-25 2009-12-30 Bayer Schering Pharma Aktiengesellschaft 7-sulfanylméthyl-, 7-sulfinylméthyl- et 7-sulfonylméthyl-indoles substitués et leur utilisation

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4450150A (en) 1973-05-17 1984-05-22 Arthur D. Little, Inc. Biodegradable, implantable drug delivery depots, and method for preparing and using the same
WO2002044120A1 (fr) * 2000-11-29 2002-06-06 Karo Bio Ab Composes ayant une action sur le recepteur glucocorticoide iii
WO2004067529A1 (fr) * 2003-01-22 2004-08-12 Eli Lilly And Company Modulateurs a base de derives indoliques des recepteurs nucleaires des hormones steroides
WO2009156072A1 (fr) * 2008-06-25 2009-12-30 Bayer Schering Pharma Aktiengesellschaft 7-sulfanylméthyl-, 7-sulfinylméthyl- et 7-sulfonylméthyl-indoles substitués et leur utilisation

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
"ASHP Handbook on Injectable Drugs", 2009, pages: 622 - 630
"Design of Controlled Release Drug Delivery Systems", 2006, MCGRAW-HILL
"Pharmaceutics and Pharmacy Practice", 1982, J.B. LIPPINCOTT COMPANY, pages: 238 - 250
STMUSZKOVIEZ, JACOB: "The Reaction of 3-acylindoles with Grignard reagents", JOURNAL OF ORGANIC CHEMISTRY, vol. 27, 1962, pages 511 - 514, XP002646106 *

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