WO2011120474A8 - Metodo para inhibir la replicacion del vih en celulas de mamiferos y en humanos - Google Patents

Metodo para inhibir la replicacion del vih en celulas de mamiferos y en humanos Download PDF

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Publication number
WO2011120474A8
WO2011120474A8 PCT/CU2011/000001 CU2011000001W WO2011120474A8 WO 2011120474 A8 WO2011120474 A8 WO 2011120474A8 CU 2011000001 W CU2011000001 W CU 2011000001W WO 2011120474 A8 WO2011120474 A8 WO 2011120474A8
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WIPO (PCT)
Prior art keywords
cytoskeleton
human cells
proteins
virus
mammal
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PCT/CU2011/000001
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English (en)
French (fr)
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WO2011120474A9 (es
WO2011120474A1 (es
Inventor
Celia Berta Fernandez Ortega
Anna Caridys RAMÍREZ SUÁREZ
Dionne Casillas Casanova
Taimi Emelia Paneque Guerrero
Raimundo UBIETA GÓMEZ
Marta DUBED ECHEVARRÍA
Leonor Margarita Navea Leyva
Lila Rosa Castellanos Serra
Carlos Antonio Duarte Cano
Viviana FALCÓN CAMA
Osvaldo Reyes Acosta
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Centro De Ingeniería Genética Y Biotecnología
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Filing date
Publication date
Priority to KR1020127028726A priority Critical patent/KR101869917B1/ko
Priority to MX2012011424A priority patent/MX2012011424A/es
Priority to ES11720370.3T priority patent/ES2604702T3/es
Priority to MYPI2012700711A priority patent/MY161923A/en
Priority to AU2011235369A priority patent/AU2011235369B2/en
Priority to RU2012146542/10A priority patent/RU2593948C2/ru
Priority to US13/637,845 priority patent/US9205128B2/en
Application filed by Centro De Ingeniería Genética Y Biotecnología filed Critical Centro De Ingeniería Genética Y Biotecnología
Priority to CA2794930A priority patent/CA2794930C/en
Priority to BR112012025092-2A priority patent/BR112012025092B1/pt
Priority to EP11720370.3A priority patent/EP2554550B1/en
Priority to JP2013501620A priority patent/JP5925759B2/ja
Priority to CN201180023063.3A priority patent/CN102884075B/zh
Publication of WO2011120474A1 publication Critical patent/WO2011120474A1/es
Publication of WO2011120474A9 publication Critical patent/WO2011120474A9/es
Priority to ZA2012/07761A priority patent/ZA201207761B/en
Publication of WO2011120474A8 publication Critical patent/WO2011120474A8/es
Priority to US14/943,096 priority patent/US20160106810A1/en
Priority to US14/943,089 priority patent/US20160129073A1/en
Priority to US14/943,106 priority patent/US10434137B2/en

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Abstract

La presente invención describe un método para inhibir la replicación del virus de la inmunodeficiencia humana (VIH) mediante la modulación negativa o alteración del citoesqueleto, específicamente de proteínas que forman parte de los filamentos intermedios del citoesqueleto, más específicamente de las proteínas vimentina y/o queratina-10. La intervención sobre la estructura de estas proteínas causa una inhibición de la replicación del virus en células humanas. La invención se relaciona además con el uso de agentes, que comprenden péptidos y/o ARN interferentes y/o compuestos lipídicos, y producen la modulación negativa o alteración del citoesqueleto celular, para prevenir o tratar la infección por el VIH. La invención proporciona medios y métodos para alterar la estructura del citoesqueleto/filamento de la célula, lo que interfiere con la infección por VIH de las células humanas y que puede incluso ser inhibida completamente. El citoesqueleto es alterado al reducir la cantidad de vimentina y/o queratina-10 (por ejemplo, por control transcripcional utilizando ARN interferentes) o mediante el uso de péptidos que alteran el citoesqueleto.
PCT/CU2011/000001 2010-04-01 2011-04-01 Metodo para inhibir la replicacion del vih en celulas de mamiferos y en humanos WO2011120474A1 (es)

Priority Applications (16)

Application Number Priority Date Filing Date Title
BR112012025092-2A BR112012025092B1 (pt) 2010-04-01 2011-04-01 Uso de um peptídeo capaz de romper os filamentos intermediários do citoesqueleto em uma célula de mamífero
ES11720370.3T ES2604702T3 (es) 2010-04-01 2011-04-01 Método para inhibir la replicación del VIH en células de mamíferos y humanos
MYPI2012700711A MY161923A (en) 2010-04-01 2011-04-01 Method to inhibit hiv replication in mammal and human cells
AU2011235369A AU2011235369B2 (en) 2010-04-01 2011-04-01 Method for inhibiting HIV replication in mammal and human cells
RU2012146542/10A RU2593948C2 (ru) 2010-04-01 2011-04-01 Способ ингибирования репликации вич в клетках млекопитающих и у людей
US13/637,845 US9205128B2 (en) 2010-04-01 2011-04-01 Method for inhibiting HIV replication in mammal and human cells
EP11720370.3A EP2554550B1 (en) 2010-04-01 2011-04-01 Method for inhibiting hiv replication in mammal and human cells
CA2794930A CA2794930C (en) 2010-04-01 2011-04-01 Method for inhibiting hiv replication in mammal and human cells
MX2012011424A MX2012011424A (es) 2010-04-01 2011-04-01 Metodo para inhibir la repilacion del virus de la inmunodeficiencia humana en celulas de mamiferos y en humanos.
KR1020127028726A KR101869917B1 (ko) 2010-04-01 2011-04-01 포유류와 인간 세포에서 ｈｉｖ 복제를 억제하는 방법
JP2013501620A JP5925759B2 (ja) 2010-04-01 2011-04-01 哺乳動物及びヒトの細胞においてｈｉｖ複製を阻害する方法
CN201180023063.3A CN102884075B (zh) 2010-04-01 2011-04-01 用于抑制在哺乳动物细胞中和在人中的hiv复制的方法
ZA2012/07761A ZA201207761B (en) 2010-04-01 2012-10-16 Method for inhibiting hiv replication in mammal and human cells
US14/943,096 US20160106810A1 (en) 2010-04-01 2015-11-17 Method for Inhibiting HIV Replication in Mammal and Human Cells
US14/943,089 US20160129073A1 (en) 2010-04-01 2015-11-17 Method for Inhibiting HIV Replication in Mammal and Human Cells
US14/943,106 US10434137B2 (en) 2010-04-01 2015-11-17 Method for inhibiting HIV replication in mammal and human cells

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CU2010000056A CU23896B1 (es) 2010-04-01 2010-04-01 Método para inhibir la replicación del vih en células de mamíferos
CU2010-0056 2010-04-01

Related Child Applications (4)

Application Number Title Priority Date Filing Date
US13/637,845 A-371-Of-International US9205128B2 (en) 2010-04-01 2011-04-01 Method for inhibiting HIV replication in mammal and human cells
US14/943,106 Continuation US10434137B2 (en) 2010-04-01 2015-11-17 Method for inhibiting HIV replication in mammal and human cells
US14/943,089 Continuation US20160129073A1 (en) 2010-04-01 2015-11-17 Method for Inhibiting HIV Replication in Mammal and Human Cells
US14/943,096 Continuation US20160106810A1 (en) 2010-04-01 2015-11-17 Method for Inhibiting HIV Replication in Mammal and Human Cells

Publications (3)

Publication Number Publication Date
WO2011120474A1 WO2011120474A1 (es) 2011-10-06
WO2011120474A9 WO2011120474A9 (es) 2012-03-22
WO2011120474A8 true WO2011120474A8 (es) 2012-11-15

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PCT/CU2011/000001 WO2011120474A1 (es) 2010-04-01 2011-04-01 Metodo para inhibir la replicacion del vih en celulas de mamiferos y en humanos

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US (4) US9205128B2 (es)
EP (1) EP2554550B1 (es)
JP (2) JP5925759B2 (es)
KR (1) KR101869917B1 (es)
CN (1) CN102884075B (es)
AR (1) AR080818A1 (es)
AU (1) AU2011235369B2 (es)
BR (1) BR112012025092B1 (es)
CA (1) CA2794930C (es)
CU (1) CU23896B1 (es)
ES (1) ES2604702T3 (es)
MX (1) MX2012011424A (es)
MY (1) MY161923A (es)
RU (1) RU2593948C2 (es)
WO (1) WO2011120474A1 (es)
ZA (1) ZA201207761B (es)

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KR102131041B1 (ko) 2013-12-03 2020-07-08 (주)아모레퍼시픽 태양광 차단 기능성 물질 스크리닝 방법 및 태양광 차단 효능 평가 방법
US9885021B2 (en) 2014-06-12 2018-02-06 Children's National Medical Center Generation of broadly-specific, virus-immune cells targeting multiple HIV antigens for preventive and therapeutic use
WO2016199964A1 (ko) * 2015-06-10 2016-12-15 주식회사 이뮨메드 분리된 비멘틴 유래 펩타이드에 특이적으로 결합하는 항체 또는 상기 펩타이드의 결합 단편
WO2016200220A1 (ko) * 2015-06-10 2016-12-15 주식회사 이뮨메드 분리된 비멘틴 유래 펩타이드에 특이적으로 결합하는 항체 또는 상기 펩타이드의 결합 단편
CU20200110A7 (es) * 2020-12-23 2022-08-09 Ct Ingenieria Genetica Biotecnologia Péptidos para el tratamiento de infecciones respiratorias de origen viral

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CN102884075A (zh) 2013-01-16
CU23896B1 (es) 2013-05-31
KR101869917B1 (ko) 2018-06-21
US20160108404A1 (en) 2016-04-21
EP2554550A1 (en) 2013-02-06
MX2012011424A (es) 2012-11-06
CA2794930A1 (en) 2011-10-06
CA2794930C (en) 2019-05-21
BR112012025092A2 (pt) 2017-01-10
KR20130027016A (ko) 2013-03-14
US20160129073A1 (en) 2016-05-12
RU2593948C2 (ru) 2016-08-10
WO2011120474A9 (es) 2012-03-22
BR112012025092B1 (pt) 2022-03-22
WO2011120474A1 (es) 2011-10-06
JP2013523662A (ja) 2013-06-17
AU2011235369B2 (en) 2015-12-24
US9205128B2 (en) 2015-12-08
JP6230635B2 (ja) 2017-11-15
US20130130971A1 (en) 2013-05-23
US20160106810A1 (en) 2016-04-21
CU20100056A7 (es) 2012-06-21
CN102884075B (zh) 2018-09-11
MY161923A (en) 2017-05-15
ES2604702T3 (es) 2017-03-08
JP5925759B2 (ja) 2016-05-25
US10434137B2 (en) 2019-10-08
ZA201207761B (en) 2013-06-26
JP2016121172A (ja) 2016-07-07
EP2554550B1 (en) 2016-09-07
RU2012146542A (ru) 2014-05-10
AR080818A1 (es) 2012-05-09

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