WO2011109880A1 - Revêtement d'origine naturelle pour source d'azote non protéique (anp), complément nutritionnel à libération progressive et contrôlée et utilisation de ceux-ci - Google Patents

Revêtement d'origine naturelle pour source d'azote non protéique (anp), complément nutritionnel à libération progressive et contrôlée et utilisation de ceux-ci Download PDF

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Publication number
WO2011109880A1
WO2011109880A1 PCT/BR2011/000053 BR2011000053W WO2011109880A1 WO 2011109880 A1 WO2011109880 A1 WO 2011109880A1 BR 2011000053 W BR2011000053 W BR 2011000053W WO 2011109880 A1 WO2011109880 A1 WO 2011109880A1
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WO
WIPO (PCT)
Prior art keywords
urea
nutritional supplement
coating
film
forming agent
Prior art date
Application number
PCT/BR2011/000053
Other languages
English (en)
Portuguese (pt)
Inventor
João Roberto FORNERETO
Original Assignee
Indústria Química Kimberlit Ltda
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Indústria Química Kimberlit Ltda filed Critical Indústria Química Kimberlit Ltda
Publication of WO2011109880A1 publication Critical patent/WO2011109880A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A23K20/147—Polymeric derivatives, e.g. peptides or proteins
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/20—Inorganic substances, e.g. oligoelements
    • A23K20/30—Oligoelements
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K40/00—Shaping or working-up of animal feeding-stuffs
    • A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
    • A23K40/35—Making capsules specially adapted for ruminants

Definitions

  • the present invention relates to formulations of a naturally occurring coating for a non-protein nitrogen source (NNP) for the production of a gradual release controlled nutritional supplement for ruminants.
  • NNP non-protein nitrogen source
  • the present invention relates to formulations of a gradual and controlled release nutritional supplement from a non-protein nitrogen source (NNP) for ruminants.
  • NNP non-protein nitrogen source
  • the present invention further relates to the use of said gradual and controlled release nutritional supplement for increasing muscle mass as well as increasing milk production in ruminants.
  • stomachs rumen, reticulum, womb and abomasum
  • symbiosis between the animal and the population of rumen bacteria and protozoa.
  • the rumen bacteria are adapted to grow at pH 6.0 - 7.0, in the absence of oxygen and at a temperature of 39 to 40 ° C. About 70 to 85% of the dry matter consumed is digested by the microbial population, producing volatile fatty acids (acetic, propionic and butyric), methane (CH 4 ), ammonia ( ⁇ 3 ⁇ 4) and microbial cells.
  • volatile fatty acids acetic, propionic and butyric
  • methane CH 4
  • ammonia ⁇ 3 ⁇ 4
  • proteolytic activity in the rumen is essentially a microbial function, since enzymes with proteolytic activity are not secreted in this compartment. gastric. Proteins are degraded by the action of microorganism enzymes (Bacteroids, Selenomonas and
  • Butirivibrio forming peptides and amino acids, which in turn can be attacked by diaminases and give rise to ammonia.
  • Non-protein nitrogen-containing compounds such as urea, thiurea, biuret, hydroxyalanine, amides and ammonium salts, are used by bacteria, which turn nitrogen into ammonia and later convert it into microbial proteins.
  • the microbial proteins synthesized in the rumen follow the alimentary transit and, in the abomasum and in the intestine, are metabolized by the enzymes of the gastrointestinal tract. This process results in amino acids that are absorbed by the intestinal villi and portal vein into the liver for later use in tissue formation.
  • Ammonia not used by the bacteria is absorbed by the ruminal epithelium and into the liver where it is converted to urea.
  • One part of the urea thus formed returns to the rumen during saliva rumination, another part returns to the rumen by diffusion through the epithelium and the remainder is eliminated by the kidneys.
  • Urea has a very high absorption coefficient and is transformed by ureolytic bacteria in ammonia (NH3), which is immediately absorbed by the epithelium of the rumen if not used by the bacteria "for the synthesis of proteins. Moreover, if the liver is unable to metabolize urea, there may be uremic poisoning due to its high concentration.
  • NH3 ammonia
  • NNP Non Protein Nitrogen
  • Nitrogen has been recognized as an essential element for animals for many years. Nitrogen use is not Protein protein in the nutrition of ruminants originated in 1879 in Germany, and in 1939 participated in the rearing of animals in the United States. Urea began to be manufactured industrially in 1870, when Bassarow promoted its synthesis from carbon dioxide and ammonia. However, it was in the period from 1914 to 1918, due to the reduction in food caused by the First World War, that Germany intensified the use of urea as a protein source in ruminant feed.
  • urea The main purpose of the use of urea was aimed at intensive production of meat-and low - cost milk (Santos, GT, et al, Proceedings of the 2nd International Symposium on Beef Cattle Milk: New concepts in nutrition UFLA, 2001; pl99-228.) .
  • NNP is not classified as protein because it is not a chain of amino acids joined by peptide bonds such as those found in plants and animals. Although there is a huge variety of NNP compounds (purines, pyrimidines, urea, biuret, uric acid, nitrogenous glycosides, ammonium salts and nitrates), urea is one of the most widely used due to its low cost, availability and use.
  • Urea has specific characteristics: it is deficient in all minerals, has no energy value of its own, has high hygroscopicity, besides being highly soluble in liquid medium. When ingested by ruminants it is rapidly solubilized and converted to ammonia by bacteria and, if given in high doses, may cause toxicity.
  • Protein degradation in the rumen is considered to be a process ranging from the conversion of dietary protein to ammonia, involving the process of digestion (protein to amino acids) and fermentation (amino acids to volatile fatty acids).
  • protein is one of the highest cost diet ingredients, and the economy of production is highly dependent on protein utilization efficiency.
  • urea is rapidly transformed into ammonia, having a lower energy cost than protein degradation.
  • Urea is normally obtained by reacting ammonia with carbon dioxide in a reactor under conditions of high temperature and pressure. Ammonia, in the presence of CO 2 from the air, forms ammonium carbamate, water and excess ammonia. At this stage the mixture passes through high and low pressure structures under vacuum, where a urea-water solution is obtained. NH 3 , CO and water (H 2 0) gases exiting the purification equipment are absorbed in the recovery section and returned to the reactor as a I recycle. Urea thus formed is not considered a protein but a non-protein nitrogenous compound.
  • NNP non-protein nitrogen
  • NNP supplementation is the excessive increase in ammonia concentration soon after urea ingestion due to the high rate of rumen hydrolysis (Owens, F. .., et al., J. Anim. Sci. 1980 ; 50: 527). Wallace, RJ, et al. observed that there is an increase in rumen bacterial growth when the ammonia concentration is increased from 9.7 to 21.4 mg / dl (Wallace, RJ, et al., Journal Appl. Bacteriology 1979; 47: 443).
  • Ammonia produced by the bacterial enzyme is used for protein synthesis and because the development of rumen microorganisms is directly related to carbohydrate digestion, this synchrony between ammonia production and the presence of Dietary carbohydrates were a major reason for the treatment of urea to be directed to the use of polymers (Henning, PH, et. al., J. Dairy Sci. 2003; 86: 2154-2162, Akay, V., et al., Annals of the Brazilian Altech Symposium 2004; 105-111).
  • US 6,620,453 describes a gradual and controlled release composition of urea for use in ruminant feeds, where the urea particles are encapsulated in a semipermeable membrane that is not degraded in the animal's rumen.
  • Said semipermeable membrane comprises in its composition a polymer-based resin (s) (eg polyurethane, polyolefins, silicones and etc.) that pass intact through the digestive system of the animal and are excreted in the environment.
  • s polymer-based resin
  • NNP non-protein nitrogen source
  • the present invention aims to provide coatings for application to a non-protein nitrogen source (NNP) which, when consumed by ruminants, have the characteristic of being fully degraded, causing no animal intoxication and leaving no residue. in meat and / or milk.
  • NNP non-protein nitrogen source
  • NNP non-protein nitrogen source
  • the present invention relates to the production of coatings of natural origin comprising at least one film-forming agent for use on a non-protein nitrogen (NNP) substrate for the production of a gradual and controlled release nutritional supplement. from a source of NNP for ruminants.
  • NNP non-protein nitrogen
  • coatings of natural origin comprise at least one film-forming agent and at least one mineral filler and / or additive.
  • said coatings of natural origin and said nutritional supplements may be sulfur additives, preferably in a nitrogen: sulfur ratio of 10: 1 to 15: 1. Even more preferably the nitrogen: sulfur ratio is 12: 1. Film Forming Agent.
  • the film-forming agent is primarily responsible for providing that the substrate to be covered is gradually released into the ruminant organism.
  • This agent should be hydrophobic, organic, nontoxic, edible, biodegradable and alcohol soluble, preferably ethanol.
  • the film-forming agent should be used at a concentration ranging from 0.1 to 10% of the total mass of the product.
  • Most common film-forming agents that may be used are: gum arabic, cellulose acetate butyrate, cellulose acetate, gelatin, casein, sorghum, wheat, barley, rice and / or corn derived prolamines, etc.
  • Preferably being used as a film-forming agent is corn-derived prolamine, also known as zein.
  • the mineral fillers and / or additives of the naturally occurring coating must be non-toxic and may be salts, vitamins and / or other micronutrients that are also required for animals and may be used in a concentration ranging from 0 to 10% relative to to the total mass of the product.
  • the most common mineral fillers and / or additives that may be used are: carbonate calcium, calcium sulfate, sulfur, magnesium oxide, magnesium salts, zinc oxide, zinc salts, cobalt oxide, copper oxide, vitamin A, methionine, lysine and / or cystine, among others.
  • sulfur, calcium carbonate, and vitamin A are used together or alone.
  • NNP Non Protein Nitrogen
  • NNP N-nitrate
  • purines pyrimidines, urea, biuret, thiurea, uric acid, nitrogenous glycosides, amides, hydroxyalanine, ammonium salts and / or nitrates, among others.
  • the source of NNP used in the present invention is urea
  • the source of NNP used in the present invention is livestock grade urea, in a concentration ranging from 80% to 99.9% relative to total mass of the product.
  • the coating should be applied to the substrate (NNP).
  • the method used may vary according to the different coating compositions provided for in the present invention.
  • the coating may be sprayed into spray on the urea inside a mixer and / or rotary dryer, and the rotation of the apparatus helps in both homogenization and drying of the product, to the equipment is added a hot air flow with a temperature not exceeding 50 ° C .
  • Another method would be to use a fluidized bed onto which the product will be sprayed, with an air temperature not exceeding 50 ° C.
  • a dredger with hot air may be used at its outlets, with a rotary dryer preferably being used.
  • the drying temperature should preferably be below 50 ° C. Higher temperatures can degrade both NPN source (urea), and the applied coating.
  • Vitamin A 0.1 - 10 3
  • Urea coated with naturally occurring polymers had a degradation time of up to 14 hours. This degradation time represents a slow and continuous solubilization, which favors the growth of the ruminal bacterial flora, due to the synchronization with the carbohydrate metabolism of the diet.

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • Animal Husbandry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Birds (AREA)
  • Fodder In General (AREA)
  • Feed For Specific Animals (AREA)

Abstract

La présente invention concerne des formulations d'un revêtement d'origine naturelle pour une source d'azote non protéique (ANP), pour la production d'un complément nutritionnel à libération progressive et contrôlée pour ruminants. Plus particulièrement, la présente invention concerne des formulations d'un complément nutritionnel à libération progressive et contrôlée d'une source d'azote non protéique (ANP) pour ruminants. La présente invention se rapporte en outre à l'utilisation dudit complément nutritionnel à libération progressive et contrôlée pour augmenter la masse musculaire ainsi que la production de lait chez des ruminants.
PCT/BR2011/000053 2010-02-25 2011-02-25 Revêtement d'origine naturelle pour source d'azote non protéique (anp), complément nutritionnel à libération progressive et contrôlée et utilisation de ceux-ci WO2011109880A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
BRPI1002177-9A BRPI1002177A2 (pt) 2010-02-25 2010-02-25 revestimento de origem natural para fonte de nitrogênio não proteìca (nnp), suplemento nutricional de liberação gradual e controlada e uso dos mesmos
BRPI1002177-9 2010-03-08

Publications (1)

Publication Number Publication Date
WO2011109880A1 true WO2011109880A1 (fr) 2011-09-15

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PCT/BR2011/000053 WO2011109880A1 (fr) 2010-02-25 2011-02-25 Revêtement d'origine naturelle pour source d'azote non protéique (anp), complément nutritionnel à libération progressive et contrôlée et utilisation de ceux-ci

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BR (1) BRPI1002177A2 (fr)
WO (1) WO2011109880A1 (fr)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017181250A1 (fr) * 2016-04-19 2017-10-26 Sion Nanotec Ltda. Composition alimentaire à base d'azote non protéique enrobée et à libération contrôlée, et procédé de préparation associé

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202047A (en) * 1967-06-02 1970-08-12 Ici Ltd Non-protein nitrogenous compositions
WO2002076718A1 (fr) * 2001-03-23 2002-10-03 Fernando Basile De Castro Produit d'uree a liberation commandee et procede de preparation de ce produit
CN1533709A (zh) * 2003-04-02 2004-10-06 吉林省禾合农业高新技术开发有限公司 缓释非蛋白氮饲料及生产工艺
BR0306289A (pt) * 2003-12-29 2004-11-16 Maeda S A Agroindustrial Uréia pecuária de liberação lenta e processo para sua fabricação
BR0305047A (pt) * 2003-08-01 2005-05-17 Marcelo Almeida Conceicao Composto alimientar para animais e seu processo de fabricação

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1202047A (en) * 1967-06-02 1970-08-12 Ici Ltd Non-protein nitrogenous compositions
WO2002076718A1 (fr) * 2001-03-23 2002-10-03 Fernando Basile De Castro Produit d'uree a liberation commandee et procede de preparation de ce produit
CN1533709A (zh) * 2003-04-02 2004-10-06 吉林省禾合农业高新技术开发有限公司 缓释非蛋白氮饲料及生产工艺
BR0305047A (pt) * 2003-08-01 2005-05-17 Marcelo Almeida Conceicao Composto alimientar para animais e seu processo de fabricação
BR0306289A (pt) * 2003-12-29 2004-11-16 Maeda S A Agroindustrial Uréia pecuária de liberação lenta e processo para sua fabricação

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017181250A1 (fr) * 2016-04-19 2017-10-26 Sion Nanotec Ltda. Composition alimentaire à base d'azote non protéique enrobée et à libération contrôlée, et procédé de préparation associé

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