WO2011090307A3 - 엔테로바이러스 ７０ 및 콕싸키바이러스 Ａ２４ 모두 동시에 항바이러스 활성을 갖는 ｓｉＲＮＡ 및 이를 함유하는 급성 출혈성 결막염 치료 및 예방용 약학조성물 - Google Patents

엔테로바이러스 ７０ 및 콕싸키바이러스 Ａ２４ 모두 동시에 항바이러스 활성을 갖는 ｓｉＲＮＡ 및 이를 함유하는 급성 출혈성 결막염 치료 및 예방용 약학조성물 Download PDF

Info

Publication number
WO2011090307A3
WO2011090307A3 PCT/KR2011/000372 KR2011000372W WO2011090307A3 WO 2011090307 A3 WO2011090307 A3 WO 2011090307A3 KR 2011000372 W KR2011000372 W KR 2011000372W WO 2011090307 A3 WO2011090307 A3 WO 2011090307A3
Authority
WO
WIPO (PCT)
Prior art keywords
coxsackievirus
enterovirus
sirna
antiviral activity
activity against
Prior art date
Application number
PCT/KR2011/000372
Other languages
English (en)
French (fr)
Other versions
WO2011090307A2 (ko
Inventor
이희란
전은정
고아라
김유겸
차흥원
안정현
원민아
Original Assignee
울산대학교 산학협력단
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 울산대학교 산학협력단 filed Critical 울산대학교 산학협력단
Publication of WO2011090307A2 publication Critical patent/WO2011090307A2/ko
Publication of WO2011090307A3 publication Critical patent/WO2011090307A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1131—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/11—Antisense

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biophysics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Plant Pathology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

본 발명은 엔테로바이러스 70 및 콕싸키바이러스 A24 모두 동시에 항바이러스 활성을 갖는 siRNA에 관한 것으로, 상기 siRNA는 급성 출혈성 결막염의 주요 원인인 엔테로바이러스 70 및 콕싸키바이러스 A24 모두에서 세포독성을 현저히 저해하고 바이러스 복제를 억제함으로써 매우 우수한 항바이러스 활성을 나타내므로 항바이러스 제제, 특히 급성 출혈성 결막염의 치료제로서 매우 유용하게 사용될 수 있다.
PCT/KR2011/000372 2010-01-19 2011-01-19 엔테로바이러스 ７０ 및 콕싸키바이러스 Ａ２４ 모두 동시에 항바이러스 활성을 갖는 ｓｉＲＮＡ 및 이를 함유하는 급성 출혈성 결막염 치료 및 예방용 약학조성물 WO2011090307A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR10-2010-0004560 2010-01-19
KR1020100004560A KR101300410B1 (ko) 2010-01-19 2010-01-19 엔테로바이러스 ７０ 및 콕싸키바이러스 Ａ２４ 모두 동시에 항바이러스 활성을 갖는 ｓｉＲＮＡ 및 이를 함유하는 급성 출혈성 결막염 치료 및 예방용 약학조성물

Publications (2)

Publication Number Publication Date
WO2011090307A2 WO2011090307A2 (ko) 2011-07-28
WO2011090307A3 true WO2011090307A3 (ko) 2011-12-29

Family

ID=44307383

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2011/000372 WO2011090307A2 (ko) 2010-01-19 2011-01-19 엔테로바이러스 ７０ 및 콕싸키바이러스 Ａ２４ 모두 동시에 항바이러스 활성을 갖는 ｓｉＲＮＡ 및 이를 함유하는 급성 출혈성 결막염 치료 및 예방용 약학조성물

Country Status (2)

Country Link
KR (1) KR101300410B1 (ko)
WO (1) WO2011090307A2 (ko)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014255381A1 (en) 2013-04-17 2015-10-08 Pfizer Inc. N-piperidin-3-ylbenzamide derivatives for treating cardiovascular diseases

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050084693A (ko) * 2002-09-13 2005-08-26 레플리코르 인코포레이티드 비서열 상보적 항바이러스 올리고뉴클레오티드
KR20090020244A (ko) * 2007-08-23 2009-02-26 울산대학교 산학협력단 콕싸키바이러스 Ａ2４에 대한 항바이러스 활성을 가지는ｓｉＲＮＡ 및 이를 포함한 급성 출혈성 결막염 치료용조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20050084693A (ko) * 2002-09-13 2005-08-26 레플리코르 인코포레이티드 비서열 상보적 항바이러스 올리고뉴클레오티드
KR20090020244A (ko) * 2007-08-23 2009-02-26 울산대학교 산학협력단 콕싸키바이러스 Ａ2４에 대한 항바이러스 활성을 가지는ｓｉＲＮＡ 및 이를 포함한 급성 출혈성 결막염 치료용조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JUN, E.J. ET AL.: "Antiviral potency of a siRNA targeting a conserved region of coxsackievirus A24", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 376, 2008, pages 389 - 394, XP025495745, DOI: doi:10.1016/j.bbrc.2008.08.169 *
LEE, H.S. ET AL.: "Universal and mutation-resistant anti-enteroviral activity: Potency of small interfering RNA complementary to the conserved cis-acting replication element within the enterovirus coding region", J. GENERAL VIROLOGY, vol. 88, 2007, pages 2003 - 2012 *

Also Published As

Publication number Publication date
WO2011090307A2 (ko) 2011-07-28
KR20110085011A (ko) 2011-07-27
KR101300410B1 (ko) 2013-08-26

Similar Documents

Publication Publication Date Title
MY170941A (en) Pyrimidine derivatives for the treatment of viral infections
WO2013123215A3 (en) Antiviral drugs for treatment of arenavirus infection
WO2011106992A8 (en) Inhibitors of hepatitis c virus ns5b polymerase
HK1123733A1 (en) Viral hepatitis treatment
MX2013012053A (es) Inhibidores de replicacion viral, su proceso de preparacion y sus usos terapeuticos.
TN2012000549A1 (en) Substituted 5-fluoro-1h-pyrazolopyridines and use thereof
WO2011158039A8 (en) Ureido-pyrazole derivatives for use in the treatment of respiratory syncitial virus (rsv) infection
MX2011011854A (es) Dihidropirimidinonas para uso como inhibidores de la bace2.
MY173422A (en) Purine derivatives for the treatment of viral infections
MX2011013176A (es) Motivos de modificación química para inhibidores y miméticos del miarn.
MX2010008531A (es) Derivados de bifenilo conformacionalmente restringido para uso como inhibidores del virus de la hepatitis c.
MX350810B (es) Derivados de los nucleosidos sustituidos en 4 '-azido, 3 '-fluoro como inhibidores de la replicacion del rna del vhc.
MY171577A (en) 2',4'-difluoro-2'-methyl substituted nucleoside derivatives as inhibitors of hcv rna replication
MX2010006033A (es) 4-(4-ciano-2-tioaril)dihidropirimidinonas y su uso.
SG179034A1 (en) 2 -aminodihydro [1, 3] thiazines as bace 2 inhibitors for the treatment of diabetes
MX2013011691A (es) Inhibidores de la replicacion viral, su proceso de preparacion y sus usos terapeuticos.
WO2011160024A3 (en) Compounds useful as antiviral agents, compositions, and methods of use
MX2010002278A (es) Farmacos antivirales para el tratamiento de una infeccion por arenavirus.
TN2012000457A1 (en) Fe(iii) complex compounds for the treatment and prophylaxis of iron deficiency symptoms and iron deficiency anemias
TN2011000204A1 (en) Cycloundecadepsipeptide compounds and use of said compounds as a medicament
MX363270B (es) Composiciones y metodos para inhibir la polimerasa viral.
UA102238C2 (en) 4-(4-cyano-2-thioaryl)dihydro-pyrimidinones and use thereof
ATE507214T1 (de) Neuartige serotonin-wiederaufnahmehemmer als arzneimittel mit peripheriesystem-beschränkter aktivität
PH12015502589A1 (en) 4`-azido, 3`-deoxy-3`-fluoro substituted nucleoside derivatives
WO2009015446A3 (en) Triazole derivatives as viral replication inhibitors

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 11734856

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 11734856

Country of ref document: EP

Kind code of ref document: A2