WO2009015446A3 - Triazole derivatives as viral replication inhibitors - Google Patents

Triazole derivatives as viral replication inhibitors Download PDF

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Publication number
WO2009015446A3
WO2009015446A3 PCT/BE2008/000059 BE2008000059W WO2009015446A3 WO 2009015446 A3 WO2009015446 A3 WO 2009015446A3 BE 2008000059 W BE2008000059 W BE 2008000059W WO 2009015446 A3 WO2009015446 A3 WO 2009015446A3
Authority
WO
WIPO (PCT)
Prior art keywords
viral replication
triazole derivatives
replication inhibitors
relates
inhibitors
Prior art date
Application number
PCT/BE2008/000059
Other languages
French (fr)
Other versions
WO2009015446A2 (en
Inventor
Johan Neyts
Ling Peng
Fanqi Que
Ruizhi Zhu
Original Assignee
Univ Leuven Kath
Univ La Mediterranee L
Centre Nat Rech Scient
Univ Wuhan
Johan Neyts
Ling Peng
Fanqi Que
Ruizhi Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Leuven Kath, Univ La Mediterranee L, Centre Nat Rech Scient, Univ Wuhan, Johan Neyts, Ling Peng, Fanqi Que, Ruizhi Zhu filed Critical Univ Leuven Kath
Publication of WO2009015446A2 publication Critical patent/WO2009015446A2/en
Publication of WO2009015446A3 publication Critical patent/WO2009015446A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C07D249/10—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The present invention relates to novel compounds and to their use as a medicament, more in particular for the treatment or prevention of viral infections in mammals. The invention also relates to processes for the preparation of compounds according to the invention and to pharmaceutical compositions comprising them.
PCT/BE2008/000059 2007-07-27 2008-07-28 Triazole derivatives as viral replication inhibitors WO2009015446A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0714649.1 2007-07-27
GBGB0714649.1A GB0714649D0 (en) 2007-07-27 2007-07-27 Novel viral replication inhibitors

Publications (2)

Publication Number Publication Date
WO2009015446A2 WO2009015446A2 (en) 2009-02-05
WO2009015446A3 true WO2009015446A3 (en) 2009-03-19

Family

ID=38512958

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/BE2008/000059 WO2009015446A2 (en) 2007-07-27 2008-07-28 Triazole derivatives as viral replication inhibitors

Country Status (2)

Country Link
GB (1) GB0714649D0 (en)
WO (1) WO2009015446A2 (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2113508A1 (en) * 2008-04-30 2009-11-04 INSERM (Institut National de la Santé et de la Recherche Medicale) Novel triazole nucleoside derivatives, their preparation and their application in therapeutics
EP2785876A4 (en) * 2011-12-02 2015-07-08 Lab Corp America Holdings Methods for the phenotypic detection of hcv inhibitor resistant subpopulations
GB201322091D0 (en) 2013-12-13 2014-01-29 Cambridge Entpr Ltd Modified serpins for the treatment of bleeding disorders
CN110713464B (en) * 2019-10-31 2023-03-31 重庆大学 Aryl 1,2,4-triazole nucleoside compound and preparation method and application thereof
CN116531361A (en) * 2022-12-01 2023-08-04 武汉大学 Application of oxygen bridge bicyclo- [2.2.1] -heptene compound in preparation of anti-novel coronavirus drugs
CN116178287A (en) * 2023-02-21 2023-05-30 宁夏大学 3-phenylethynyl-1, 2, 4-triazole derivative and preparation method thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067002A2 (en) * 2006-09-11 2008-06-05 Southern Research Institute Azole nucleosides and use as inhibitors of rna and dna varial polymerases

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008067002A2 (en) * 2006-09-11 2008-06-05 Southern Research Institute Azole nucleosides and use as inhibitors of rna and dna varial polymerases

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
FIRTH A G ET AL: "Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: fluorescence properties of compact conjugated acetylenes containing a purine ring", TETRAHEDRON LETTERS, ELSEVIER, AMSTERDAM, vol. 47, no. 21, 22 June 2006 (2006-06-22), pages 3529 - 3533, XP002455121, ISSN: 0040-4039 *
GEORGES-COURBOT M C ET AL: "Poly(I)-poly(C12U) but not ribavirin prevents death in a hamster model of Nipah virus infection.", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY MAY 2006, vol. 50, no. 5, May 2006 (2006-05-01), pages 1768 - 1772, XP002509671, ISSN: 0066-4804 *
MANFREDINI S ET AL: "Pyrazole-Related Nucleosides. Synthesis and Anitviral/Antitumor Activity of Some Substituted Pyrazole and Pyrazolo[4,3-d]-1,2,3-triaz in-4-one Nucleosides", JOURNAL OF MEDICINAL CHEMISTRY, US AMERICAN CHEMICAL SOCIETY. WASHINGTON, vol. 35, 1 January 1992 (1992-01-01), pages 917 - 924, XP002018485, ISSN: 0022-2623 *
ROBLES J ET AL: "NUCLEIC ACID TRIPLE HELICES: STABILITY EFFECTS OF NUCLEOBASE MODIFICATIONS", CURRENT ORGANIC CHEMISTRY, HILVERSUM, NL, vol. 6, no. 14, 1 January 2002 (2002-01-01), pages 1333 - 1368, XP009068763, ISSN: 1385-2728 *
ZHU R ET AL: "Arylethynyltriazole acyclonucleosides inhibit hepatitis C virus replication", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, PERGAMON, ELSEVIER SCIENCE, GB, vol. 18, no. 11, 1 June 2008 (2008-06-01), pages 3321 - 3327, XP022711221, ISSN: 0960-894X, [retrieved on 20080415] *

Also Published As

Publication number Publication date
WO2009015446A2 (en) 2009-02-05
GB0714649D0 (en) 2007-09-05

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