WO2011090271A3 - 여지핵 추출물을 포함하는 지방간 또는 비만의 예방 또는 치료용 조성물 - Google Patents
여지핵 추출물을 포함하는 지방간 또는 비만의 예방 또는 치료용 조성물 Download PDFInfo
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- WO2011090271A3 WO2011090271A3 PCT/KR2010/009445 KR2010009445W WO2011090271A3 WO 2011090271 A3 WO2011090271 A3 WO 2011090271A3 KR 2010009445 W KR2010009445 W KR 2010009445W WO 2011090271 A3 WO2011090271 A3 WO 2011090271A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- preventing
- fatty liver
- present
- liver
- obesity
- Prior art date
Links
- 208000010706 fatty liver disease Diseases 0.000 title abstract 6
- 239000000203 mixture Substances 0.000 title abstract 5
- 208000004930 Fatty Liver Diseases 0.000 title abstract 3
- 206010019708 Hepatic steatosis Diseases 0.000 title abstract 3
- 241001629511 Litchi Species 0.000 title abstract 3
- 208000008589 Obesity Diseases 0.000 title abstract 3
- 239000000284 extract Substances 0.000 title abstract 3
- 235000020824 obesity Nutrition 0.000 title abstract 3
- 231100000240 steatosis hepatitis Toxicity 0.000 title abstract 3
- 102000000536 PPAR gamma Human genes 0.000 abstract 2
- 108091008767 PPARγ2 Proteins 0.000 abstract 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 abstract 2
- 230000000694 effects Effects 0.000 abstract 2
- 210000005228 liver tissue Anatomy 0.000 abstract 2
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 238000009825 accumulation Methods 0.000 abstract 1
- 210000000577 adipose tissue Anatomy 0.000 abstract 1
- 235000012000 cholesterol Nutrition 0.000 abstract 1
- 235000013305 food Nutrition 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 150000002632 lipids Chemical class 0.000 abstract 1
- 210000004185 liver Anatomy 0.000 abstract 1
- 230000003908 liver function Effects 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000000877 morphologic effect Effects 0.000 abstract 1
- 230000035790 physiological processes and functions Effects 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 230000035897 transcription Effects 0.000 abstract 1
- 238000013518 transcription Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/332—Promoters of weight control and weight loss
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2250/00—Food ingredients
- A23V2250/20—Natural extracts
- A23V2250/21—Plant extracts
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Obesity (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Child & Adolescent Psychology (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Epidemiology (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Medicines Containing Plant Substances (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
본 발명은 여지핵 추출물을 포함하는 지방간 또는 비만의 예방 또는 치료용 조성물에 관한 것이다. 본 발명의 조성물은 체지방량의 감소, 내장 지방량의 감소, 총 콜레스테롤 농도의 감소, 지방조직생성에 중요한 역할을 담당하는 핵전사요소인 C/EBPα와 PPARγ2, 그리고 이들의 타겟유전자인 aP2 유전자의 발현량 감소를 초래하여, 궁극적으로 비만의 예방 또는 치료 활성을 나타낸다. 본 발명의 조성물은 간의 형태적, 구조적, 생리학적 기능을 유지하도록 지방간 질환의 진행을 억제하고 치료할 수 있으며, 더불어 그 발생을 예방하는 효과도 있다. 특히, 본 발명의 조성물은 간 조직 내에 존재하는 지질함량을 감소시킴으로써 간 조직 내의 지방축적을 개선하고, 간 기능 지표 효소의 활성을 정상화하여 지방간 발생의 예방, 진행 억제 또는 질병 상태를 호전시킬 수 있는 효과도 있다. 또한, 본 발명은 비만 및 지방간 예방 및 치료 효능을 가지는 여지핵 추출물의 의약 및 식품으로서의 기초적인 자료를 제공한다.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201080061825.4A CN102740871B (zh) | 2010-01-19 | 2010-12-28 | 包含荔枝核提取物的脂肪肝或肥胖的预防或治疗用组合物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2010-0004913 | 2010-01-19 | ||
| KR1020100004913A KR100969170B1 (ko) | 2010-01-19 | 2010-01-19 | 여지핵 추출물을 포함하는 지방간 또는 비만의 예방 또는 치료용 조성물 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2011090271A2 WO2011090271A2 (ko) | 2011-07-28 |
| WO2011090271A3 true WO2011090271A3 (ko) | 2011-11-24 |
Family
ID=42645361
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/KR2010/009445 WO2011090271A2 (ko) | 2010-01-19 | 2010-12-28 | 여지핵 추출물을 포함하는 지방간 또는 비만의 예방 또는 치료용 조성물 |
Country Status (3)
| Country | Link |
|---|---|
| KR (1) | KR100969170B1 (ko) |
| CN (1) | CN102740871B (ko) |
| WO (1) | WO2011090271A2 (ko) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101213825B1 (ko) | 2010-07-16 | 2012-12-18 | 서울대학교산학협력단 | 세린을 유효성분으로 함유하는 지방간 질환의 예방 및 치료용 조성물 |
| CN103168884B (zh) * | 2013-03-06 | 2014-07-02 | 华南理工大学 | 一种含荔枝核的减肥茶及其茶包的制备方法 |
| KR20140118531A (ko) * | 2013-03-29 | 2014-10-08 | 현대약품 주식회사 | 여지핵 및 한인진 추출물을 유효성분으로 포함하는 비만의 예방, 개선 또는 치료용 조성물 |
| CN103623110B (zh) * | 2013-12-13 | 2016-03-02 | 广州大正新材料科技有限公司 | 一种减肥粉及其制备方法 |
| CN104922271B (zh) * | 2015-05-27 | 2018-05-04 | 广西壮族自治区中国科学院广西植物研究所 | 荔枝皮多酚在制备降低肝脏胆固醇的药物或保健品中的应用 |
| KR20210017343A (ko) | 2019-08-08 | 2021-02-17 | 농업회사법인 오스바이오 주식회사 | 올리고당으로 발효된 미나리 추출물을 유효성분으로 포함하는 알코올성 지방간 예방 및 치료용 조성물 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001131046A (ja) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | 過酸化水素消去剤及びこれを含有する化粧料。 |
| KR20040021602A (ko) * | 2001-05-10 | 2004-03-10 | 코니스 프랑스, 에스.에이. | 올리고머성 프로안트로시아니딘의 용도 |
| JP2008500032A (ja) * | 2004-05-25 | 2008-01-10 | コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 経口および／または局所用組成物 |
-
2010
- 2010-01-19 KR KR1020100004913A patent/KR100969170B1/ko active IP Right Grant
- 2010-12-28 CN CN201080061825.4A patent/CN102740871B/zh not_active Expired - Fee Related
- 2010-12-28 WO PCT/KR2010/009445 patent/WO2011090271A2/ko active Application Filing
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001131046A (ja) * | 1999-11-04 | 2001-05-15 | Pola Chem Ind Inc | 過酸化水素消去剤及びこれを含有する化粧料。 |
| KR20040021602A (ko) * | 2001-05-10 | 2004-03-10 | 코니스 프랑스, 에스.에이. | 올리고머성 프로안트로시아니딘의 용도 |
| JP2008500032A (ja) * | 2004-05-25 | 2008-01-10 | コグニス・アイピー・マネージメント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 経口および／または局所用組成物 |
Non-Patent Citations (1)
| Title |
|---|
| DENG-JYE YANG ET AL.: "Protective effect of a litchi (Litchi chinensis Sonn.)-flower-water-extract on cardiovascular health in a high-fat/cholesterol-dietary hamsters", FOOD CHEMISTRY, vol. 119, no. ISS.4, 11 September 2009 (2009-09-11), pages 1457 - 1464 * |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011090271A2 (ko) | 2011-07-28 |
| CN102740871B (zh) | 2015-11-25 |
| CN102740871A (zh) | 2012-10-17 |
| KR100969170B1 (ko) | 2010-07-14 |
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