WO2011076971A3 - Artículo de peek poroso como implante - Google Patents

Artículo de peek poroso como implante Download PDF

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Publication number
WO2011076971A3
WO2011076971A3 PCT/ES2010/070867 ES2010070867W WO2011076971A3 WO 2011076971 A3 WO2011076971 A3 WO 2011076971A3 ES 2010070867 W ES2010070867 W ES 2010070867W WO 2011076971 A3 WO2011076971 A3 WO 2011076971A3
Authority
WO
WIPO (PCT)
Prior art keywords
peek polymer
porous
temperature
implant
porous peek
Prior art date
Application number
PCT/ES2010/070867
Other languages
English (en)
French (fr)
Other versions
WO2011076971A2 (es
Inventor
Beatriz Olalde Graells
María Jesús Jurado Oñate
Original Assignee
Fundacion Inasmet
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundacion Inasmet filed Critical Fundacion Inasmet
Priority to CA2785571A priority Critical patent/CA2785571A1/en
Priority to US13/518,669 priority patent/US20120323339A1/en
Publication of WO2011076971A2 publication Critical patent/WO2011076971A2/es
Publication of WO2011076971A3 publication Critical patent/WO2011076971A3/es

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/26—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a solid phase from a macromolecular composition or article, e.g. leaching out
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
    • C08J9/28—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof by elimination of a liquid phase from a macromolecular composition or article, e.g. drying of coagulum
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/042—Elimination of an organic solid phase
    • C08J2201/0422—Elimination of an organic solid phase containing oxygen atoms, e.g. saccharose
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/044—Elimination of an inorganic solid phase
    • C08J2201/0444—Salts
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/044—Elimination of an inorganic solid phase
    • C08J2201/0444—Salts
    • C08J2201/0446—Elimination of NaCl only
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2201/00—Foams characterised by the foaming process
    • C08J2201/04—Foams characterised by the foaming process characterised by the elimination of a liquid or solid component, e.g. precipitation, leaching out, evaporation
    • C08J2201/052—Inducing phase separation by thermal treatment, e.g. cooling a solution
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2205/00—Foams characterised by their properties
    • C08J2205/04—Foams characterised by their properties characterised by the foam pores
    • C08J2205/05—Open cells, i.e. more than 50% of the pores are open
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2207/00—Foams characterised by their intended use
    • C08J2207/10—Medical applications, e.g. biocompatible scaffolds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2371/00—Characterised by the use of polyethers obtained by reactions forming an ether link in the main chain; Derivatives of such polymers
    • C08J2371/08—Polyethers derived from hydroxy compounds or from their metallic derivatives
    • C08J2371/10—Polyethers derived from hydroxy compounds or from their metallic derivatives from phenols
    • C08J2371/12—Polyphenylene oxides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/249921—Web or sheet containing structurally defined element or component
    • Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
    • Y10T428/249986—Void-containing component contains also a solid fiber or solid particle

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dermatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Manufacture Of Porous Articles, And Recovery And Treatment Of Waste Products (AREA)
  • Materials For Medical Uses (AREA)

Abstract

La presente invención se refiere a un artículo de polímero de tipo PEEK poroso que comprende una estructura de polímero de tipo PEEK porosa y que presenta al menos una distribución de poros trimodal. La invención describe un procedimiento para la producción de dicho artículo de polímero de tipo PEEK poroso que comprende: a) poner en contacto un polímero de tipo PEEK con una composición que comprende al menos un disolvente orgánico, b) calentar a una temperatura a la que se disuelve el polímero de tipo PEEK, c) añadir al menos un agente porógeno, d) enfriar la mezcla obtenida en c) a una temperatura al menos igual o menor que la temperatura a la que precipita el polímero de tipo PEEK, e) conformar dicha mezcla enfriada para dar un artículo conformado, f) retirar el disolvente orgánico y el agente porógeno, y g) recuperar el artículo de polímero de tipo PEEK.
PCT/ES2010/070867 2009-12-23 2010-12-23 Artículo de peek poroso como implante WO2011076971A2 (es)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CA2785571A CA2785571A1 (en) 2009-12-23 2010-12-23 Porous peek article as an implant
US13/518,669 US20120323339A1 (en) 2009-12-23 2010-12-23 Porous peek article as an implant

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP09382298.9 2009-12-23
EP09382298 2009-12-23
EP10382243.3A EP2338532B1 (en) 2009-12-23 2010-09-10 Porous PEEK article as an implant
EP10382243.3 2010-09-10

Publications (2)

Publication Number Publication Date
WO2011076971A2 WO2011076971A2 (es) 2011-06-30
WO2011076971A3 true WO2011076971A3 (es) 2011-10-06

Family

ID=42144854

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/ES2010/070867 WO2011076971A2 (es) 2009-12-23 2010-12-23 Artículo de peek poroso como implante

Country Status (5)

Country Link
US (1) US20120323339A1 (es)
EP (1) EP2338532B1 (es)
CA (1) CA2785571A1 (es)
ES (1) ES2664944T3 (es)
WO (1) WO2011076971A2 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080206297A1 (en) 2007-02-28 2008-08-28 Roeder Ryan K Porous composite biomaterials and related methods
US11179243B2 (en) 2007-02-28 2021-11-23 Happe Spine Llc Implantable devices
RU2552939C2 (ru) 2009-11-25 2015-06-10 Дифьюжн Текнолоджиз, Инк. Пост-загрузка покрытых цеолитом пластиков антимикробными ионами металлов
CN102834122B (zh) 2009-12-11 2015-03-11 扩散技术公司 制备聚醚醚酮抗微生物植入物的方法
WO2011140416A2 (en) 2010-05-07 2011-11-10 Difusion Technologies, Inc. Medical implants with increased hydrophilicity
GB201117633D0 (en) * 2011-10-12 2011-11-23 Invibio Ltd Polymeric materials
CA2882591C (en) 2012-08-21 2021-01-12 Avery Dennison Corporation Systems and methods for making porous films, fibers, spheres, and other articles
CN102973983B (zh) * 2012-12-02 2015-01-07 复旦大学 一种水溶性致孔剂、多孔支架及其制备方法
EP2749300A1 (en) * 2012-12-26 2014-07-02 Universidad Del Pais Vasco-Euskal Herriko Unibertsitatea Modified polyaryletherketone polymer (PAEK) and process to obtain it
JP2016511415A (ja) * 2013-03-15 2016-04-14 アイデックス ヘルス アンド サイエンス エルエルシー 改良された生体適合性フィルタ
US9295565B2 (en) 2013-10-18 2016-03-29 Spine Wave, Inc. Method of expanding an intradiscal space and providing an osteoconductive path during expansion
US9504550B2 (en) 2014-06-26 2016-11-29 Vertera, Inc. Porous devices and processes for producing same
US9517593B2 (en) 2014-06-26 2016-12-13 Vertera, Inc. Apparatus and process for producing porous devices
WO2015200896A1 (en) * 2014-06-26 2015-12-30 Vertera, Inc. Porous devices and processes for producing same
US9085665B1 (en) 2014-12-31 2015-07-21 Vertera, Inc. Method for producing porous material
US9498922B2 (en) 2014-06-26 2016-11-22 Vertera, Inc. Apparatus and process for producing porous devices
USD815281S1 (en) 2015-06-23 2018-04-10 Vertera, Inc. Cervical interbody fusion device
EP3187196A1 (en) * 2015-12-29 2017-07-05 Fundacíon Tecnalia Research & Innovation Uhmwpe-type polymer article, process for its production and implantand/or scaffold made thereof
US10251752B2 (en) 2015-12-31 2019-04-09 DePuy Synthes Products, Inc. Modular femoral prosthesis system for hip arthroplasty
CN106178104B (zh) * 2016-08-29 2019-12-10 上海交通大学 一种医用可载药多孔聚醚醚酮及其制造方法和应用
JP7208893B2 (ja) * 2016-10-06 2023-01-19 ソルベイ スペシャルティ ポリマーズ ユーエスエー， エルエルシー ポリマーと添加剤を含む多孔質物品、それらの調製法およびそれらの使用
CN107961398B (zh) * 2017-11-29 2020-05-26 南宁越洋科技有限公司 可增强骨结合的骨组织工程支架材料人工牙根的制备方法
WO2020097720A1 (en) * 2018-11-12 2020-05-22 Groupe Ppd Inc. Porous material and process
CN109432494B (zh) * 2018-11-20 2021-04-23 中国科学院长春应用化学研究所 一种表面具有特殊拓扑形貌的peek微球及其制备方法和应用
WO2020186103A1 (en) 2019-03-12 2020-09-17 Happe Spine Llc Implantable medical device with thermoplastic composite body and method for forming thermoplastic composite body
CN110724300B (zh) * 2019-09-24 2021-09-21 西南交通大学 一种在聚醚醚酮支架表面构建多孔结构的方法
US11576787B2 (en) 2019-09-30 2023-02-14 DePuy Synthes Products, Inc. Patient specific femoral prosthesis
US11351034B2 (en) 2019-09-30 2022-06-07 DePuy Synthes Products, Inc. Patient specific femoral prosthesis
CN112941656B (zh) * 2021-02-03 2022-11-15 中山大学 热诱导相分离法制备聚芳醚酮纳米纤维及其衍生物
CN113754918B (zh) * 2021-09-29 2022-11-08 复旦大学 一种表面改性的聚醚醚酮材料及其制备方法与应用

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US3772059A (en) * 1970-04-13 1973-11-13 Kanegafuchi Spinning Co Ltd Method for producing microporous sheet material
GB1486867A (en) * 1976-04-23 1977-09-28 Chloride Group Ltd Porous sheet materials
WO2007051307A2 (en) * 2005-11-04 2007-05-10 Ppd Meditech Porous material and method for fabricating same

Also Published As

Publication number Publication date
US20120323339A1 (en) 2012-12-20
EP2338532B1 (en) 2018-01-10
CA2785571A1 (en) 2011-06-30
WO2011076971A2 (es) 2011-06-30
EP2338532A2 (en) 2011-06-29
EP2338532A3 (en) 2013-03-20
ES2664944T3 (es) 2018-04-24

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