WO2011072500A1 - 一种手脚去死皮角质的有机酸组合物及含该组合物的膜片 - Google Patents

一种手脚去死皮角质的有机酸组合物及含该组合物的膜片 Download PDF

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Publication number
WO2011072500A1
WO2011072500A1 PCT/CN2010/070537 CN2010070537W WO2011072500A1 WO 2011072500 A1 WO2011072500 A1 WO 2011072500A1 CN 2010070537 W CN2010070537 W CN 2010070537W WO 2011072500 A1 WO2011072500 A1 WO 2011072500A1
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Prior art keywords
organic acid
acid composition
exfoliating
skin
composition
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PCT/CN2010/070537
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English (en)
French (fr)
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王金源
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品牌亚太有限公司
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Publication of WO2011072500A1 publication Critical patent/WO2011072500A1/zh

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/66—Enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9794—Liliopsida [monocotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/10—Washing or bathing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants

Definitions

  • the present invention relates to a composition for removing exfoliation of hands and feet and a film containing the same, and an organic acid composition having an effect of removing skin dead skin and keratin is applied to an adsorption layer of the film to make an organic acid composition.
  • the exfoliating and keratinous ingredients achieve a high degree of bacteriostatic rate for optimal exfoliation and exfoliation.
  • the skin of the sole of the foot is prone to thick skin due to long-term friction and pressure; the skin of the hand is also prone to thicker keratin due to work friction.
  • the industry is generally used to remove dead skin thick skin from hands and feet.
  • the products are mainly sputum and exfoliating foot film.
  • the dead skin cells of the skin are mainly composed of keratin, which is insoluble in water and insoluble in oil, but can be decomposed by strong bases, strong acids or protein-decomposing enzymes. Therefore, the industry's sputum or exfoliating foot film solution is mostly made of a solution containing a strong base such as sodium hydroxide, commonly known as caustic soda; or a solution containing a high concentration of hydroxyl acid, commonly known as fruit acid.
  • the present invention provides an organic acid composition exfoliating the hands and feet and a film containing the composition.
  • the present invention firstly provides an organic acid composition for removing dead skin cells by hand and foot, comprising: (1) an organic acid and a salt thereof, 3 to 30% by weight, based on the total weight of the organic acid composition.
  • the organic acid and its salts form a buffer with a pH of 1.5 to 4.5; (2) a proteolytic enzyme, 0.5 to 20%; and (3) a skin soothing agent, 0.2 to 10%.
  • the present invention also provides a preferred technical solution of the above-mentioned hand and foot exfoliating organic acid composition: the organic acid composition further comprises a thickener and/or a moisturizer;
  • the viscous agent is natural xanthan gum, hydroxyethyl cellulose or carboxymethyl cellulose;
  • the humectant is glycerol, propylene glycol, butanediol, hexitol or amino acid;
  • the viscous agent is 0.5 to 6% by weight of the total weight of the organic acid composition, and the humectant is 3 to 25% by weight.
  • the organic acid comprises at least one of acetic acid, glycolic acid, lactic acid, malic acid, tartaric acid, citric acid, acetic acid, bamboo vinegar, and salicylic acid, and a buffer having a pH of 2.5 to 3.5 is formed with the salt thereof.
  • Its salt is preferably a sodium salt thereof;
  • the proteolytic enzyme comprises at least one of papain, pineapple enzyme, and milk fermentation filtrate;
  • the skin soothing agent is a plant extract, at least from marigold, white flower chamomile flower, European silk flower, cornflower flower , an extract from the mother chrysanthemum, St. John's wort, willow bark, and ginkgo leaves.
  • the present invention still further provides a membrane comprising the above-mentioned hand and foot exfoliating organic acid composition, the membrane having an adsorption layer and a separation layer, and the adsorption layer adsorbing the organic acid composition.
  • the invention also provides a preferred technical solution of the above diaphragm:
  • An organic acid composition is disposed between the separation layer and the adsorption layer, and the two are adhered by the organic acid composition;
  • the adsorption layer is made of non-woven fabric, dust-free paper or ordinary cotton cloth to absorb and release the organic acid composition;
  • the separator is made of polyethylene, polypropylene or polyvinyl chloride.
  • the hand and foot exfoliating organic acid composition provided by the invention has the characteristics of effectively removing dead skin and keratin on the hands and feet and having mildness, low irritation and no toxic side effects.
  • the membrane containing the organic acid composition provided by the present invention can be uniformly applied or coated on a desired portion by adsorbing the organic acid composition of the exfoliating keratin of the hands and feet to an adsorption layer having an adsorption function. It is evenly applied or coated and uniformly and efficiently conducted to the desired portion.
  • the diaphragm contains a barrier layer that blocks the adsorption liquid from coming into contact with the air, achieving waterproof, breathable and enhanced dead skin and keratin absorption.
  • the film can be coated on the hand or foot or attached to a specific part, or can be cut into an appropriate size, size or shape, so that the film can be closely attached to the human body, and the skin can be more effectively removed from the specific part of the body.
  • Figure 1 is a perspective view of a diaphragm provided by the present invention.
  • FIG. 2 is an exploded perspective view of a diaphragm provided by the present invention.
  • FIG. 3 is a schematic view showing an application embodiment of a diaphragm provided by the present invention.
  • FIG. 4 is a schematic view of another application embodiment of a diaphragm provided by the present invention.
  • FIG. 5 is a schematic view showing still another application embodiment of the diaphragm provided by the present invention.
  • the organic acid composition provided by the invention is different from the general alkaline decocting liquid or the acidic foot film liquid.
  • the composite dead skin and keratin decomposition technology of the invention has the following main features: (1) appropriate amount The organic acid and its salts form a buffer solution; (2) a protein decomposing enzyme; (3) a skin soothing agent; a thickening and adhesion viscous agent; (5) a humectant; and (6) a solvent;
  • a buffer solution formed of an organic acid and a salt thereof (such as a buffer solution formed of an organic acid and a sodium salt or a potassium salt thereof):
  • the organic acid used in the present invention has a small molecular weight, and after dilution, is non-irritating to the skin,
  • the toxic effect, especially the aqueous solution of a small molecule organic acid containing a hydroxyl group, has less irritating and toxic effects on the skin.
  • Hydroxy-containing small molecule organic acids include glycolic acid (common name glycolic acid), hydroxypropionic acid (common name lactic acid), malic acid, citric acid and salicylic acid and other organic acids and their salts, which can form various acid and alkali The value of the buffer solution.
  • Partially neutralized organic acid buffer solution stabilizes the pH of the solution and is milder to the skin than the unbuffered free acid.
  • the human skin has a pH of 3.5 to 6.0, and the acidity and alkalinity of the organic acid must be lower than the pH of the skin to help break down the skin's dead skin and keratin. Therefore, the buffer of the organic acid and the salt thereof provided by the present invention must have a good exfoliation and keratin effect at a pH of 1.5 to 4.5, preferably 2.5 to 3.5, and the organic acid content is 3. From % to 30% is preferred.
  • proteolytic enzyme used in the present invention may be derived from a fruit enzyme such as papain, pineapple enzyme or a protein degrading enzyme in a milk fermentation broth, and a proteolytic enzyme may help break down dead skin and keratin protein.
  • the irritation of the organic acid to the skin can be alleviated, and the proteolytic enzyme contained in the present invention is from 0.5% to 20% by weight based on the total weight of the organic acid composition.
  • the viscous agent used in the present invention may be natural xanthan gum or cellulose gum; the cellulose gum may be hydroxyethyl cellulose or carboxymethyl cellulose, which is included in the present invention.
  • the amount of the thickener is from 0.5% to 6%.
  • the solvent used in the present invention includes a solvent such as water, ethanol or glycerin for dissolving an organic acid and a thickener in an amount of 10% to 60%.
  • the humectant used in the present invention may be a polyhydric alcohol humectant such as glycerin, propylene glycol, butanediol or hexitol, or an amino acid humectant or a humectant. It can maintain the moisture of organic acid and its salt buffer to prevent water loss, to maintain the concentration of buffer, the moisturizer The content is from 3% to 25%.
  • the present invention further comprises a skin soothing agent, which may be a plant extract, such as aloe extract, calendula extract, chamomile extract, cornflower extract, white chrysanthemum extract, A plant extract such as a European scented flower extract, a mother chrysanthemum extract, a St. John's wort extract, a willow extract or a ginkgo biloba extract, and the skin soothing agent is contained in an amount of 0.2% to 15%.
  • a skin soothing agent which may be a plant extract, such as aloe extract, calendula extract, chamomile extract, cornflower extract, white chrysanthemum extract, A plant extract such as a European scented flower extract, a mother chrysanthemum extract, a St. John's wort extract, a willow extract or a ginkgo biloba extract, and the skin soothing agent is contained in an amount of 0.2% to 15%.
  • the membrane 1 has adsorption.
  • the material of the adsorption layer 3 may be a non-woven fabric, a dust-free paper or a general cotton cloth to absorb or release the organic acid composition thereon.
  • the separator 4 has a waterproof and gas-tight function and is bonded to the adsorption layer 3 on the other side of the organic acid composition, and the material thereof may be a thin layer of a polymer such as polyethylene or polypropylene. The separator 4 can effectively isolate the air, avoid volatilization of the organic acid composition, and improve the utilization of the organic acid composition.
  • each time is about 45 to 60 minutes, then washed with warm water, and dried with a dry cloth, skin dead skin
  • the keratin will fall off by itself within 5 ⁇ 10 days; the organic acid composition 2 consisting of a new chemical formula achieves better exfoliation and exfoliation, and has the functions of soothing, moisturizing and moisturizing.
  • the membrane 1 provided by the invention can be cut-off in addition to the original coated hand-foot film. When used, it is not necessary to cover the whole foot in the membrane, and the membrane 1 of appropriate size can be cut and attached. Exfoliate and exfoliate parts. The location of keratin is different from person to person.
  • the invention can cut out the diaphragm 1 of different shapes for the parts requiring exfoliation and keratin, such as the diaphragm for the rear heel, the sole of the foot and the finger, which can effectively exfoliate and exfoliate the target part, Will damage unnecessary skin tissue.
  • Tables 2 and 3 show the test results of skin membrane and foot organic acid composition for 12 subjects, respectively. Tables 4 and 5 are divided into 20-30 years old, 30-40 years old, 40-50 years old. In the three groups, the skin patch test and the organic acid composition test results of the foot were performed. Table 2. Occlusive skin patch test

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Description

一种手脚去死皮角质的有机酸组合物及含该组合物的膜片 技术领域
本发明涉及一种手脚去死皮角质的组合物及含有该组合物的膜片， 在膜 片的吸附层敷上具有去除皮肤死皮、 角质效果的有机酸组合物， 使有机酸组 合物中的去死皮及角质成份达到高度的抑菌率， 达到最佳去死皮及去角质的 效果。
背景技术
脚底皮肤因为长期走路的磨擦和压力， 容易形成死皮厚茧； 手部皮肤也 容易因为工作磨擦而容易形成较厚角质。 业界一般用于手脚皮肤去除死皮厚 茧的产品以去茧液及去角质足膜为主。 皮肤的死皮角质主要是由角蛋白质所 构成， 角蛋白质不溶于水， 也不溶于油， 但是可被强碱、 强酸或蛋白质分解 酶所分解。 因此， 业界的去茧液或去角质足膜液， 多以强碱如氢氧化钠， 俗 称苛性钠的溶液制成； 或以含高浓度的氢氧基酸， 俗称果酸的溶液制成。
无论用强碱或高浓度的氢氧基酸， 对皮肤都会有某种程度的刺激和敏感 作用， 有人使用强碱去茧液或高浓度果酸的足膜造成皮肤敏感、 红肿、 受伤。 因此， 一种有效的去死皮、 角质又低刺激的安全产品为有死皮厚茧的困扰者 所需要， 也是此领域的技术人员所欲解决的问题。
用于手脚皮肤去除死皮厚茧、 角质的产品， 除了在组成份上有强碱或果 酸性之外，使用方式也不同，有些去茧液是直接涂抹在有死皮或厚茧部位 3~5 分钟后， 再用去角质磨砂棒将软化的死皮角质搓磨去除； 有些去角质足膜则 是制成套袋状， 其内装有强碱的去茧液或高浓度果酸溶液的去角质液， 包覆 50~120分钟后， 再以清水清洗皮肤， 5~7天后， 死皮、 角质会逐渐剥落。 由 于人们走路习惯不同， 与地接触时所摩擦的部位也不同， 故脚底所生成的死 皮角质的部位与厚度也不尽相同。 因此， 全脚包覆式的套袋式足膜无法针对 特定较厚的死皮厚茧加以去除； 而涂抹式的去茧液产品， 虽可针对特定部位 涂抹处理， 但是其涂抹的去茧液容易因为暴露在空气中而挥发流失， 降低其 有效成份。 另外， 一般的去茧液可分解软化死皮角质， 却无法让死皮角质自 然脱落， 必须利用去角质磨砂棒等器械来搓除软化分解的死皮角质， 不但麻 烦， 倘若用力不当， 还会使皮肤受伤。
发明内容
鉴于现有技术的上述不足， 本发明提供了一种手脚去死皮角质的有机酸 组合物及含有该组合物的膜片。
本发明首先提供了一种手脚去死皮角质的有机酸组合物， 包含有， 以有 机酸组合物总重的重量百分比计， （1)有机酸及其盐类， 3~30% , 且所述有机 酸与其盐类形成 pH = 1.5~4.5 的缓冲液； （2)蛋白质分解酶， 0.5~20%； 及 (3) 皮肤舒缓剂， 0.2~10%。
本发明还提供了上述手脚去死皮角质的有机酸组合物的优选技术方案： 所述有机酸组合物还包含有粘稠剂和 /或保湿剂；
所述粘稠剂为天然黄原胶、 羟乙基纤维素或羧甲基纤维素；
所述保湿剂为丙三醇、 丙二醇、 丁二醇、 己六醇或胺基酸类；
以有机酸组合物总重的重量百分比计， 所述粘稠剂 0.5~6% , 保湿剂 3~25%。
所述有机酸至少包含有乙酸、 羟乙酸、 乳酸、 苹果酸、 酒石酸、 柠檬酸、 醋酸、 竹醋液、 水杨酸中的一种， 且与其盐类形成 pH = 2.5~3.5 的缓冲液， 其盐类优选为其钠盐；
所述蛋白质分解酶至少包含有木瓜酶、 菠萝酶、 牛奶发酵滤液中的一种； 所述皮肤舒缓剂为植物提取物， 至少从金盏花、 白花春黄菊花、 欧洲椴 花、 矢车菊花、 母菊花、 贯叶连翘、 柳皮、 银杏叶中的一种提取。
本发明还进一步提供了包含有上述手脚去死皮角质的有机酸组合物的膜 片， 该膜片具有吸附层和隔离层， 吸附层吸附有有机酸组合物。 本发明还提供了上述膜片的优选技术方案：
隔离层与吸附层之间为有机酸组合物， 二者通过有机酸组合物相贴合； 所述吸附层的材质为不织布、 无尘纸或一般棉布， 以吸收、 释放有机酸 组合物；
所述隔离层的材质为聚乙烯、 聚丙烯或聚氯乙烯。
本发明提供的手脚去死皮角质有机酸组合物具有能有效地去除手脚上的 死皮、 角质且具有温和、 刺激性低、 无毒副作用的特点。 本发明提供的含有 该有机酸组合物的膜片， 能均匀的贴覆或包覆于需要的部位， 方法是将前述 手脚去死皮角质的有机酸组合物吸附于具有吸附作用的吸附层， 使其均匀地 贴覆或包覆， 并均匀有效地传导至需要的部位。 膜片包含的隔离层可以阻隔 吸附液与空气接触， 达到了防水、 防透气及提高死皮、 角质吸收有效成份的 作用。 该膜片可以包覆于手足或贴覆于特定部位， 也可自行剪裁成适当尺寸、 大小或形状， 以使膜片能够紧贴于人体， 达到更有效地去除人体特定部位皮 肤的死皮、 角质的目的。
附图说明
图 1为本发明提供的膜片的立体外观图。
图 2为本发明提供的膜片的立体分解图。
图 3为本发明提供的膜片的应用实施方式示意图。
图 4为本发明提供的膜片的另一应用实施方式示意图。
图 5为本发明提供的膜片的再一应用实施方式示意图。
图中， 1为膜片； 2为有机酸组合物； 3为吸附层； 4为隔离层。
具体实施方式
以下实施例仅用于说明本发明， 而不限制本发明的保护范围。
本发明提供的有机酸组合物， 有别于一般巿售碱性去茧液或是酸性足膜 液， 本发明釆用复合式死皮、 角质分解技术， 其主要特征为： 含有 (1)适量的 有机酸及其盐类形成缓冲溶液； （2)蛋白质分解酶； （3)皮肤舒缓剂； （4)具有增 稠及粘着作用的粘稠剂； （5)保湿剂； 和 (6)溶剂；
一、 对本发明提供的有机酸组合物的说明
下述含量均为重量百分比， 以有机酸组合物总重为基准。
(1) . 有机酸及其盐类形成的缓冲溶液（如有机酸与其钠盐或钾盐形成的 缓冲溶液）： 本发明所用的有机酸分子量较小， 经稀释后， 对皮肤无刺激、 无 毒害作用， 尤其是含有羟基的小分子有机酸的水溶液对皮肤的刺激、 毒害作 用更小。 含羟基的小分子有机酸包括羟基乙酸（俗名甘醇酸）、 羟基丙酸（俗 名乳酸）、 苹果酸、 柠檬酸及水杨酸等有机酸与其盐类的水溶液， 可形成各种 不同酸碱值的缓冲溶液 (buffer solution)。 部份中和的有机酸缓冲溶液， 可稳定 溶液的酸碱值， 对皮肤的刺激性也比未经缓冲的游离酸温和。 但是， 人类皮 肤的酸碱值为 3.5至 6.0, 有机酸的酸碱值必须低于皮肤的酸碱值， 才具有帮 助分解皮肤死皮、 角质的作用。 因此， 本发明提供的有机酸及其盐类的缓冲 液必须在 pH值 1.5至 4.5才具有较好的去死皮、 角质的作用， 较好的情况是 2.5至 3.5 , 有机酸的含量为 3%至 30%较佳。
(2) . 蛋白质分解酶： 本发明所用的蛋白质分解酶可来自水果的酶， 如木 瓜酶、 菠萝酶或牛奶发酵液中的蛋白质分解酶， 蛋白质分解酶可帮助分解死 皮、 角质蛋白， 也可以缓和有机酸对皮肤的刺激性， 本发明所含的蛋白质分 解酶为 0.5%至 20% (重量百分比， 以有机酸组合物总重为基准 )。
(3) . 粘稠剂： 本发明所用的粘稠剂可为天然的黄原胶或纤维素胶类； 纤 维素胶类可为羟乙基纤维素或羧甲基纤维素， 本发明所含的粘稠剂的量为 0.5%至 6%。
(4) . 溶剂： 本发明所用的溶剂包括水、 乙醇、 甘油等溶剂， 用于溶解有 机酸及粘稠剂， 其含量为 10%至 60%。
(5) . 保湿剂： 本发明所用的保湿剂可为丙三醇 (甘油)、 丙二醇、 丁二醇、 己六醇等多元醇类保湿剂， 也可为胺基酸类保湿剂， 保湿剂可以维持有机酸 及其盐类缓冲液的水份， 防止水份散失， 以维持缓冲液的浓度， 该保湿剂的 含量为 3%至 25%。
(6). 皮肤舒缓剂： 本发明进一步含有皮肤舒缓剂， 可为植物提取液， 如 芦荟提取液、 金盏提取液、 洋甘菊花提取液、 矢车菊花提取液、 白花春黄菊 花提取液、 欧洲椴花提取液、 母菊花提取液、 贯叶连翘提取液、 柳皮提取液 或银杏叶提取液等植物萃取液， 该皮肤舒缓剂的含量为 0.2%至 15%。
二、 本发明提供的膜片
请参阅图 1、 图 2、 图 3、 图 4、 图 5 , 图中， 手脚去死皮、 角质的有机 酸组合物 2及含有该有机酸组合物的膜片 1 , 该膜片 1具有吸附层 3以及隔 离层 4。 其中， 吸附层 3的材质可为不织布、 无尘纸或一般棉布， 以吸收或 释放其上的有机酸组合物。 隔离层 4具有防水、 不透气的功能， 与吸附层 3 相贴合， 位于有机酸组合物的另一侧， 其材质可为聚乙烯、 聚丙烯等高分子 聚合物的薄层。 该隔离层 4能有效地隔离空气， 避免有机酸组合物挥发， 提 高该有机酸组合物的利用率。
使用此手脚去死皮及去角质的有机酸组合物及含有该有机酸组合物的膜 片 1时， 每次约 45~60分钟， 然后用温水洗净， 并用干布擦干， 皮肤死皮、 角质将在 5~10天内自行脱落； 由新的化学配方组成的有机酸组合物 2, 达到 了较佳的去死皮及去角质的效果， 同时具有舒缓、 滋润及保湿的作用。 本发 明提供的膜片 1除了为原来包覆式手足膜之外， 也可为剪裁式， 使用时， 不 必将全脚掌包覆于膜片内， 可剪裁适当大小的膜片 1 , 贴在欲去死皮及去角 质的部位即可。 因角质生成的部位因人而异， 如运动员因短跑加速、 减速常 常会摩擦到脚后跟及脚掌； 女性穿高跟鞋时， 会摩擦到前脚掌， 故其角质产 生的部位及厚度皆不尽相同。 本发明可针对需要去死皮、 角质的部位， 剪裁 出不同形状的膜片 1 , 如用于后脚跟、 脚底板、 指头的膜片， 可有效地针对 目标部位进行去死皮、 角质， 不会伤害到不必要的皮肤组织。
三、 本发明提供的有机酸组合物及含有该组合物膜片的安全性：
2009年 8月 10日， 在嘉南药理科技大学， 选了 12名受测者， 进行人体 皮肤的刺激性实验， 实验结果证明： 本发明提供的手脚去死皮、 角质的有机 酸组合物及含有该组合物的膜片于皮肤、 足部皆无红斑、 红疹、 搔痒、 红肿、 疼痛等刺激性反应。
本测试试验所用的有机酸组合物釆用三种配比方式分别进行试验。
表 1. 有机酸组合物的三种配比方式
Figure imgf000008_0001
表 2及表 3分别为 12名受测者进行皮肤膜片、足部敷有机酸组合物测试 结果， 表 4及表 5分别为分成 20~30岁、 30~40岁、 40~50岁的三组， 进行皮 肤膜片测试、 足部敷有机酸组合物测试结果。 表 2. 闭锁性皮肤膜片测试
Figure imgf000009_0001
表 3: 开放性足部敷样品
Figure imgf000009_0002
Figure imgf000009_0003
以上为本发明的一较佳实施例， 用于说明本发明的具体实施方式， 而非 限制本发明的保护范围。

Claims

权利要求书
1. 一种手脚去死皮角质的有机酸组合物， 包含有， 以有机酸组合物总重 的重量百分比计， （1)有机酸及其盐类， 3~30%； (2)蛋白质分解酶， 0.5~20%； 及 (3)皮肤舒缓剂， 0.2~10%； 其特征在于： 所述有机酸与其盐类形成 pH = 1.5-4.5的缓冲液。
2. 如权利要求 1所述手脚去死皮角质的有机酸组合物， 其特征在于： 所 述有机酸组合物还包含有粘稠剂和 /或保湿剂。
3. 如权利要求 2所述的手脚去死皮角质的有机酸组合物， 其特征在于： 所述粘稠剂为天然黄原胶、 羟乙基纤维素或羧甲基纤维素， 所述保湿剂为丙 三醇、 丙二醇、 丁二醇、 己六醇或胺基酸类； 以有机酸组合物总重的重量百 分比计， 粘稠剂 0.5~6% , 保湿剂 3~25%。
4. 如权利要求 1所述的手脚去死皮角质的有机酸组合物， 其特征在于： 所述有机酸至少包含有乙酸、 羟基乙酸、 乳酸、 苹果酸、 酒石酸、 柠檬酸、 醋酸、 竹醋液或水杨酸中的一种， 且与其盐类形成 pH = 2.5~3.5的缓冲液。
5. 如权利要求 1所述的手脚去死皮角质的有机酸组合物， 其特征在于： 所述蛋白质分解酶至少包含有木瓜酶、 菠萝酶或牛奶发酵液中的蛋白质分解 酶中的一种。
6. 如权利要求 1所述的手脚去死皮角质的有机酸组合物， 其特征在于： 所述皮肤舒缓剂为植物提取物， 至少从芦荟、 洋甘菊花、 金盏、 白花春黄菊 花、 欧洲椴花、 矢车菊花、 母菊花、 贯叶连翘、 柳皮或银杏叶中的一种提取。
7. 包含权利要求 1 ~6 任一项所述的手脚去死皮角质的有机酸组合物的 膜片， 其特征在于： 所述膜片具有吸附层和隔离层， 吸附层吸附有机酸组合
8. 如权利要求 7所述的膜片，其特征在于：所述吸附层的材质为不织布、 无尘纸或棉布， 以吸收或释放所述有机酸组合物。
9. 如权利要求 7所述的膜片， 其特征在于： 隔离层与吸附层之间为有机 酸组合物， 隔离层与吸附层通过有机酸组合物相贴合。
10.如权利要求 7所述的膜片，其特征在于：所述隔离层的材质为聚乙烯、 聚丙烯或聚氯乙烯。
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