WO2011062533A1 - Soupape de trachéotomie - Google Patents

Soupape de trachéotomie Download PDF

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Publication number
WO2011062533A1
WO2011062533A1 PCT/SE2010/000274 SE2010000274W WO2011062533A1 WO 2011062533 A1 WO2011062533 A1 WO 2011062533A1 SE 2010000274 W SE2010000274 W SE 2010000274W WO 2011062533 A1 WO2011062533 A1 WO 2011062533A1
Authority
WO
WIPO (PCT)
Prior art keywords
membrane
passageway
valve
seating surface
rim
Prior art date
Application number
PCT/SE2010/000274
Other languages
English (en)
Inventor
Daniel Ekeberg
Inge Blomquist
Original Assignee
Fogless International Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fogless International Ab filed Critical Fogless International Ab
Priority to DK10831862.7T priority Critical patent/DK2501424T3/en
Priority to ES10831862.7T priority patent/ES2669177T3/es
Priority to EP10831862.7A priority patent/EP2501424B1/fr
Priority to NO10831862A priority patent/NO2501424T3/no
Priority to CN201080061555.7A priority patent/CN102811756B/zh
Priority to CA2784501A priority patent/CA2784501C/fr
Publication of WO2011062533A1 publication Critical patent/WO2011062533A1/fr
Priority to HK13106445.3A priority patent/HK1179544A1/zh

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0465Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
    • A61M16/0468Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters with valves at the proximal end limiting exhalation, e.g. during speaking or coughing
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M16/00Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
    • A61M16/04Tracheal tubes
    • A61M16/0465Tracheostomy tubes; Devices for performing a tracheostomy; Accessories therefor, e.g. masks, filters
    • A61M16/047Masks, filters, surgical pads, devices for absorbing secretions, specially adapted therefor

Definitions

  • the present invention relates to a tracheostomy valve allowing a patient to speak which is intended to be attached to the end of a tracheostomy tube in order to regulate air flow through said tube.
  • the valve is in a closed state when the patient with the tracheostomy valve exhales (and possibly speaks) and opens only when the patient inhales, allowing air to flow through the tracheostomy valve and through the tracheotomy tube to the patients lungs.
  • the tracheostomy valve is specifically designed to facilitate the speech of the patient.
  • a tracheostomy valve comprising a valve body having a first inner end, a second outer end, and a passageway extending between said ends through the valve body allowing air to flow from and trough said first end to said second end.
  • Outer in this context means facing away from the patient (i.e. from the tracheostomy tube) and inner means facing the patient.
  • the first inner end thus is adapted to be attachable to the tracheostomy tube.
  • a transverse flexible membrane is located within the passageway at a distance from said first end.
  • a rib is located in the passageway transversely to the direction of the air flow through said passageway in the vicinity of the outer end.
  • a post is located at the center of the rib on the outer side of the rib. This post is intended to cooperate with a central hole in the membrane to hold the membrane in place.
  • the rib has a slightly raised portion adjoining the post.
  • a cap can be secured to the outer end of the valve having an opening with a diameter largely corresponding to the inner diameter of the passageway, said opening defining a rim.
  • the cap is provided with a hub, radial spokes extending from said hub to said rim.
  • the hub is provided with a hole designed to mate with said post.
  • the rim is provided with a seating ring on the inner side (i.e.
  • the central part of the membrane will be clamped between said hub and said raised portion on the rib.
  • the seating ring is offset inwards relative to the inner surface of the hub.
  • the object of the present invention is to obtain a tracheotomy valve of the general kind described above which opens immediately upon inhalation and which closes immediately and positively at the end of inhalation.
  • the air flow through valve also should be optimized.
  • the valve should remain closed and sealed during exhalation and should not open until the next inhalation. One reason that this is important is to allow the patient to speak clearly. It is also desirable that the opening and the closing of the valve is fast and substantially noiseless.
  • the valve as such also should minimize noise.
  • Fig 1 is a three-dimensional longitudinal section of an embodiment of the tracheotomy valve according to the invention seen from the outer side,
  • Fig 2 is a three-dimensional longitudinal section of an embodiment of the tracheotomy valve according to the invention seen from the inner side, the sectional surface being perpendicular to the sectional surface in Fig 1
  • Fig 3 is a planar section A - A of the section of the valve in Fig 1 taken perpendicularly to the section in Fig 1,
  • Fig 4 is a section B - B of the valve in Fig 1, parallel to the section A - A, but slightly offset,
  • Fig 5 is an exploded three-dimensional view of another embodiment of the invention in which the membrane has an oval shape
  • the expressions “inner “ or “inwardly” indicate the part(s) or feature(s) being closest to, oriented towards or facing the patient.
  • the expressions “outer” or “outwardly” indicate the part(s) being farthest away from, oriented away from or facing away from the patient when the valve is attached to a tracheotomy tube.
  • FIGs 1 - 4 A first preferred embodiment of the invention is shown in Figs 1 - 4.
  • This embodiment comprises a tracheostomy valve with a valve body (1) having two ends, a first inner end (la), a second outer end (lb), and a passageway extending between said ends (la, lb) through the valve body allowing air to flow from and through said first end (la) to and through said second end (lb).
  • the passageway is circular in cross-section.
  • the outside of the inner end (la) is provided with a conical shape (3) to mate with a standard tracheotomy tube.
  • a beam (2a) is arranged diametrically in the outer end (lb) of the valve body (1).
  • a post (2) with a circular cross-section is arranged centrally and directed perpendicularly outwardly on the outer side of the beam (2a).
  • the valve also comprises a circular membrane (7) placed on the outer side of the beam (2a).
  • the membrane (7) has a circular hole (10) at the center having a diameter corresponding to the diameter of the post (2).
  • the post (2) extends through the hole (10) in the membrane (7).
  • the outer surface of the first beam (2a) is straight and planar.
  • the valve also comprises a cap (4) which is secured to the outer end (lb) of the valve body (1).
  • the cap has a circular opening with a diameter largely corresponding to the inner diameter of the passageway. This opening has a circular rim (14).
  • the cap is provided with a second beam (2b).
  • the inner surface of said second beam (2b) is also straight and planar.
  • the distance between the two beams (2a, 2b) corresponds to the thickness of the membrane (7).
  • the membrane (7) thus is held between the first beam (2a) and the second beam (2b) (See Fig 1).
  • the second beam (2b) is provided with a central hole (6) corresponding in size and shape to the post (2).
  • the post (2) is engaged in this hole (6), thus further securing the membrane to the beams (2a, 2b).
  • the rim is provided with a seating surface (5) along the inner periphery of the rim (14).
  • the seating surface (5) faces inwardly towards the membrane for supporting the periphery of the membrane (7).
  • the second beam (2b) is provided with a central hub (18) in which the hole (6) is formed. Ribs (spokes) (13 a - f) extend radially from the hub (18) to the rim (14).
  • the second beam (2b), the ribs (13 a - f) and the rim (14) thus form a grid (4a).
  • the seating surface (5) is arranged to coincide with the inner surface of the second beam (lb) at each end of the beam (2b), as for instance can be seen in Figs 2 and 3.
  • the seating surface (5) on each side of said second beam (2b) is progressively and increasingly offset inwardly to reach a maximum distance from a transverse plane through the inner surface of the second beam (2b) after a quarter of the circumference of the circular rim (14).
  • the seating surface (5) is then progressively and decreasingly offset outwardly to the second end of the beam (2b). If the longest distance between the second beam (2b) and the seating surface (5) is R, the maximal offset may for instance be 0.2R.
  • the inner surfaces (i. e. of the grid 4a) of the second beam (2b) and the ribs (13 a - f) are curved and the seating surface (5) merges smoothly and continuously with the inner surfaces of said ribs (13 a - f) and the inner surface of the second beam (2b).
  • the inner surfaces of the radial ribs (13 a - f), the seating surface (5) and the inner surface of the second beam (2b) i.e. the inner surface of the grid
  • Another way of visualizing the surface defined by the inner sides the grid would be the curved shape or periphery of a completely flexible circular membrane placed on top of the outer cylindrical surface of a cylinder.
  • the apex or highest point would be located on and along the inner surface of the second beam (2b).
  • the inner shape of the grid (4a) need not necessarily be cylindrical.
  • a parabolic or hyperbolic shape with an apical generatrix similarly located along the second beam (2b) could also be used as well as any other similar curve.
  • each one of the beam (2b), the ribs (13 a - f) and the seating surface (5) thus will support the membrane (7) along its entire length.
  • membrane (7) has been left out in Fig 2 in order to better illustrate the curved shapes of the inner side of the second beam (2b), of the inner surface of the ribs (13 a - f) and of the seating surface (5).
  • Figs 3 and 4 illustrate the function of the valve.
  • Fig 3 the valve is shown in a closed state.
  • the section is taken through the post (2).
  • the membrane (7) located on the planar outer surface of the first beam is given a vaulted shape defined the grid as described above. Since the membrane (7) normally is planar, the membrane when mounted will be preloaded against the curved inside of the grid (4a) and consequently into a positively closed and sealing position against the seating ring (5) at all times except when the patient inhales.
  • the general curvature of the inner side of the grid also will shape and hold the membrane in such a way that the risk for any folds or wrinkles at the edge of the membrane is minimized, the membrane being flexed in only one direction (the direction of the generatrix) over its entire width.
  • Fig 4 the valve is shown in the open state, i. e. when the patient inhales.
  • the direction of the air flow is indicated by the arrows (15).
  • This view is parallel to, but slightly offset from the section in Fig 3 and consequently the first beam (2a) can be seen in cross-section.
  • the membrane (7) bends away from the seating surface (5) in two segments along the two sides of the outer surface of the first beam (2a). Since the distance between the two beams (2a, 2b) is equal to the thickness of the membrane (7), the entire diameter of the membrane will be held in contact with the outer surface of the first beam (2a) along the entire length of said beam. The edges of the first beam (2a) thus will positively guide the flexing movement of the respective membrane segment.
  • the membrane (7) also is held without constraints in the space between the first and second beam (2a, 2b).
  • the first feature will minimize the influence of any folds, wrinkles or other irregularities in the membrane (7) and the second will minimize the risk for such folds, wrinkles or irregularities caused by clamping or otherwise constraining the membrane (7). This consequently means that the membrane easily will open to the maximum extent possible.
  • the edges of the outer surface of the first beam (2a) preferably are rounded, which further will facilitate the flexing of the membrane (7) as well as improve the aerodynamic properties of the passageway. When the membrane flexes towards its closed position the membrane might progressively follow the curved grid from the central part to the seating ring, thus improving the noise characteristics.
  • the valve body and the cap may be provided with orienting means ensuring that the beams (2a, 2b) are located along each other when the valve is assembled.
  • the orienting means comprise splines (8) located in one or several locations along the periphery.
  • the passageway and the membrane (7') are generally elliptical in cross-section and the valve body (1 ') is adapted to conform to this shape.
  • the first beam (2 'a) is then arranged along the major axis of the ellipse. In this case it is important to prevent the membrane (7') from rotating and consequently the outer side of the first beam is provided with at least two posts (2', 2") cooperating with
  • the posts (2', 2") could for instance be located so as to divide the length of the first beam (2a') into three equal parts or alternatively be located in the foci of the ellipse.
  • the opening in the cap (4') also is elliptical with the second beam (2b') located at the major axis of the ellipse.
  • the second beam (2b') is provided with holes (6', 6") corresponding to the posts (2 ' , 2 ' ' ).
  • the ribs (13 'a - d) forming the grid can be arranged in different ways relative to the beam (2b ' ).
  • all ribs (13 'a - d) could be arranged perpendicularly to the beam (2b') or the ribs on the side of the posts facing the respective small ends of the ellipse could be arranged more or less radially centered on the respective post and the ribs located in the space between the posts could be arranged perpendicularly to the beam.
  • cap 4 ' does not include any other features than the grid 4a'except that the outside is adapted to fit into the passageway.
  • the inside of the grid (4a ' ) is shaped cylindrically, parabolically, hyperbolically or otherwise in same way as in the above first embodiment.
  • One advantage with an elliptical cross-section is that the height of the valve is minimized if the major axis of the valve is oriented transversely to the patient's throat, the valve thus being more comfortable to wear.
  • the membrane also could have a superelliptic shape.
  • the superelliptic shape could even verge towards a rectangular shape.
  • this embodiment corresponds to the first embodiment although being adapted to the elliptical/superelliptical shape where necessary.
  • the posts are located on the first beam and the holes in the second beam. It is however quite possible to locate the posts on the second beam and the holes in the first beam.
  • valve in common with tracheostomy valves in general also may be provided with connections for a ventilating machine and/or an oxygen supply and/or with filters and/or with a shower/heat shield.
  • the ribs may be provided with a cross-section shaped as a narrow, symmetrical airfoil in order to improve the aerodynamics of the valve.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pulmonology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Prostheses (AREA)
  • Respiratory Apparatuses And Protective Means (AREA)

Abstract

La présente invention concerne une soupape de trachéotomie qui comprend un corps de soupape (1) doté d'une première extrémité interne (Ia), d'une seconde extrémité externe (Ib) et d'un passage qui s'étend entre lesdites extrémités (Ia, Ib) à travers le corps de soupape pour permettre à l'air de s'écouler depuis et à travers ladite première extrémité (Ia) jusqu'à et à travers ladite seconde extrémité (Ib). Ledit corps présente un premier montant (2a) situé dans le passage, de manière transversale à la direction du flux d'air à travers ledit passage à l'extrémité externe, et une membrane (7) souple transversale située dans le passage sur la surface externe dudit montant (2a). Ladite soupape comprend en outre une coiffe (4) qui peut être fixée à l'extrémité externe (Ib) de la soupape dotée d'une ouverture, dont la taille correspond largement à la taille interne du passage. L'ouverture est définie par un rebord circonférentiel (14). La coiffe est pourvue d'un second montant (2b) situé parallèlement le long du premier montant (2a) et la membrane (7) est maintenue entre ledit premier montant (2a) et ledit second montant (2b). Le premier montant (2a) et le second montant (2b) sont pourvus de moyens de fixation (2, 17) qui permettent de fixer en outre ladite membrane (7) entre ledit premier montant (2a) et ledit second montant (2b). Le rebord est pourvu d'une surface d'assise (5) tournée vers l'intérieur afin de soutenir la périphérie de ladite membrane (7). Le second montant est pourvu de nervures (13 a-f) qui s'étendent depuis ledit second montant (2b) jusqu'audit rebord (14). Le second montant (2b) forme une grille (4a) avec les nervures (13 a-f) et le rebord (14). La membrane (7) est préchargée dans une position fermée en direction de ladite surface d'assise (5). La surface externe dudit premier montant (2a) est droite et plane. La surface interne dudit second montant (2b) est droite et plane. L'espace entre lesdits premier (2a) et second (2b) montants correspond de préférence à l'épaisseur de ladite membrane (7). De préférence, la surface d'assise (5) sur chaque côté dudit second montant (2b) est progressivement et de plus en plus décalée vers l'intérieur à partir d'un plan le long du côté interne dudit second montant, depuis une distance zéro à une première extrémité dudit montant (2b), pour atteindre une distance maximale ; la surface d'assise (5) est alors progressivement et de moins en moins décalée vers l'extérieur jusqu'à une distance zéro sur ledit plan à la seconde extrémité dudit montant (2b) et ladite surface d'assise fusionne doucement et continuellement avec les surface internes desdites nervures (13a-f).
PCT/SE2010/000274 2009-11-17 2010-11-16 Soupape de trachéotomie WO2011062533A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
DK10831862.7T DK2501424T3 (en) 2009-11-17 2010-11-16 Tracheostomy valve
ES10831862.7T ES2669177T3 (es) 2009-11-17 2010-11-16 Válvula de traqueotomía
EP10831862.7A EP2501424B1 (fr) 2009-11-17 2010-11-16 Soupape de trachéotomie
NO10831862A NO2501424T3 (fr) 2009-11-17 2010-11-16
CN201080061555.7A CN102811756B (zh) 2009-11-17 2010-11-16 气管造口术阀
CA2784501A CA2784501C (fr) 2009-11-17 2010-11-16 Soupape de tracheotomie
HK13106445.3A HK1179544A1 (zh) 2009-11-17 2013-05-31 氣管造口術閥

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE0901460A SE0901460A1 (sv) 2009-11-17 2009-11-17 Andnings-talventil
SE0901460-6 2009-11-17

Publications (1)

Publication Number Publication Date
WO2011062533A1 true WO2011062533A1 (fr) 2011-05-26

Family

ID=44059831

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE2010/000274 WO2011062533A1 (fr) 2009-11-17 2010-11-16 Soupape de trachéotomie

Country Status (10)

Country Link
EP (1) EP2501424B1 (fr)
CN (1) CN102811756B (fr)
CA (1) CA2784501C (fr)
DK (1) DK2501424T3 (fr)
ES (1) ES2669177T3 (fr)
HK (1) HK1179544A1 (fr)
NO (1) NO2501424T3 (fr)
SE (1) SE0901460A1 (fr)
TR (1) TR201807241T4 (fr)
WO (1) WO2011062533A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014060242A1 (fr) * 2012-10-17 2014-04-24 Tracoe Medical Gmbh Valve de phonation destinée à une canule de trachéotomie
WO2014110105A1 (fr) * 2013-01-10 2014-07-17 Covidien Lp Canule à soupape d'articulation vocale à indication de saturation
EP2991736A4 (fr) * 2013-04-28 2016-12-21 Kudav Mahesh Soupape d'expiration de type papillon
GB2579364A (en) * 2018-11-29 2020-06-24 Kapitex Healthcare Ltd An improved speaking valve
CN112969489A (zh) * 2018-11-09 2021-06-15 无雾国际公司 包括挠性构件的气管造口阀

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11554471B2 (en) * 2014-08-28 2023-01-17 Power Tech Staple and Nail, Inc. Elastomeric exhaust reed valve for combustion driven fastener hand tool
DE102014018678B4 (de) * 2014-12-18 2021-11-11 Andreas Fahl Medizintechnik-Vertrieb Gmbh Tracheostomaschutz
CN109965972B (zh) * 2017-12-27 2021-06-29 先健科技(深圳)有限公司 造口器械
SE545828C2 (en) 2020-03-02 2024-02-13 Fogless Int Ab An additive hood for humidifying air entering into a tracheostomy valve

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5806515A (en) * 1997-03-28 1998-09-15 Passy-Muir, Inc. Supplemental oxygen adapter for tracheostomy speaking valves
WO2002074377A1 (fr) * 2001-03-19 2002-09-26 Ab Fogless International Valve de respiration et de phonation
WO2008132222A2 (fr) * 2007-04-30 2008-11-06 Atos Medical Ab Protecteur respiratoire
WO2009018384A1 (fr) * 2007-07-30 2009-02-05 Passy-Muir, Inc. Valvules de trachéostomie et procédés apparentés

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US7025784B1 (en) * 1981-10-29 2006-04-11 Hansa Medical Products, Inc. Method and apparatus for a tracheal valve
JPS62502103A (ja) * 1985-03-08 1987-08-20 ミュ−ア,デヴィッド・エイ 気管切開装置
NL8803202A (nl) * 1988-12-29 1990-07-16 Mijnhardt Bv Ademventiel.
GB9515986D0 (en) * 1995-08-04 1995-10-04 Racal Health & Safety Ltd Uni-directional fluid valve
US6334441B1 (en) * 1998-11-23 2002-01-01 Mallinckrodt Medical, Inc. Phonation valve for breathing tube
CA2509750A1 (fr) * 2002-12-16 2004-07-22 Children's Hospital Medical Center Unite de valve de tracheotomie
GB2404866B (en) * 2003-08-15 2008-02-27 Shahar Hayek Respiratory apparatus
US8297318B2 (en) * 2005-05-21 2012-10-30 Mark Johnson Check valve

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5806515A (en) * 1997-03-28 1998-09-15 Passy-Muir, Inc. Supplemental oxygen adapter for tracheostomy speaking valves
WO2002074377A1 (fr) * 2001-03-19 2002-09-26 Ab Fogless International Valve de respiration et de phonation
WO2008132222A2 (fr) * 2007-04-30 2008-11-06 Atos Medical Ab Protecteur respiratoire
WO2009018384A1 (fr) * 2007-07-30 2009-02-05 Passy-Muir, Inc. Valvules de trachéostomie et procédés apparentés

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014060242A1 (fr) * 2012-10-17 2014-04-24 Tracoe Medical Gmbh Valve de phonation destinée à une canule de trachéotomie
US10034992B2 (en) 2012-10-17 2018-07-31 Tracoe Medical Gmbh Speaking valve
WO2014110105A1 (fr) * 2013-01-10 2014-07-17 Covidien Lp Canule à soupape d'articulation vocale à indication de saturation
EP2991736A4 (fr) * 2013-04-28 2016-12-21 Kudav Mahesh Soupape d'expiration de type papillon
AU2014264187B2 (en) * 2013-04-28 2018-05-10 Mahesh Kudav Butterfly type exhalation valve
CN112969489A (zh) * 2018-11-09 2021-06-15 无雾国际公司 包括挠性构件的气管造口阀
US20210393909A1 (en) * 2018-11-09 2021-12-23 Fogless International Ab Tracheostomy valve comprising a flexible membrane
TWI827713B (zh) * 2018-11-09 2024-01-01 瑞典商佛格列斯國際有限公司 氣管切開術閥
GB2579364A (en) * 2018-11-29 2020-06-24 Kapitex Healthcare Ltd An improved speaking valve
GB2579364B (en) * 2018-11-29 2021-08-18 Kapitex Healthcare Ltd An improved speaking valve

Also Published As

Publication number Publication date
ES2669177T3 (es) 2018-05-24
EP2501424A4 (fr) 2014-10-29
NO2501424T3 (fr) 2018-08-18
TR201807241T4 (tr) 2018-06-21
CA2784501C (fr) 2018-09-18
HK1179544A1 (zh) 2013-10-04
CA2784501A1 (fr) 2011-05-26
CN102811756A (zh) 2012-12-05
EP2501424A1 (fr) 2012-09-26
SE0901460A1 (sv) 2011-05-18
CN102811756B (zh) 2016-04-13
DK2501424T3 (en) 2018-06-06
EP2501424B1 (fr) 2018-03-21

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