WO2011055980A3 - 산화아연-결합성 펩타이드를 포함하는 단백질과 산화아연 나노입자의 복합체 및 그의 용도 - Google Patents
산화아연-결합성 펩타이드를 포함하는 단백질과 산화아연 나노입자의 복합체 및 그의 용도 Download PDFInfo
- Publication number
- WO2011055980A3 WO2011055980A3 PCT/KR2010/007726 KR2010007726W WO2011055980A3 WO 2011055980 A3 WO2011055980 A3 WO 2011055980A3 KR 2010007726 W KR2010007726 W KR 2010007726W WO 2011055980 A3 WO2011055980 A3 WO 2011055980A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- zinc oxide
- composite
- protein
- drug delivery
- bonding
- Prior art date
Links
- 239000002131 composite material Substances 0.000 title abstract 5
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 title abstract 4
- XLOMVQKBTHCTTD-UHFFFAOYSA-N Zinc monoxide Chemical compound [Zn]=O XLOMVQKBTHCTTD-UHFFFAOYSA-N 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000011701 zinc Substances 0.000 title abstract 4
- 229910052725 zinc Inorganic materials 0.000 title abstract 4
- 102000004169 proteins and genes Human genes 0.000 title abstract 3
- 108090000623 proteins and genes Proteins 0.000 title abstract 3
- 239000002105 nanoparticle Substances 0.000 title abstract 2
- 239000011787 zinc oxide Substances 0.000 title abstract 2
- 238000012377 drug delivery Methods 0.000 abstract 4
- 239000002872 contrast media Substances 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 238000001727 in vivo Methods 0.000 abstract 2
- 206010020843 Hyperthermia Diseases 0.000 abstract 1
- 241001646398 Pseudomonas chlororaphis Species 0.000 abstract 1
- 239000011324 bead Substances 0.000 abstract 1
- 230000001413 cellular effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 230000036031 hyperthermia Effects 0.000 abstract 1
- 238000003384 imaging method Methods 0.000 abstract 1
- 238000011503 in vivo imaging Methods 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229940124597 therapeutic agent Drugs 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001103—Receptors for growth factors
- A61K39/001106—Her-2/neu/ErbB2, Her-3/ErbB3 or Her 4/ErbB4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001102—Receptors, cell surface antigens or cell surface determinants
- A61K39/001111—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001148—Regulators of development
- A61K39/00115—Apoptosis related proteins, e.g. survivin or livin
- A61K39/001151—Apoptosis related proteins, e.g. survivin or livin p53
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001152—Transcription factors, e.g. SOX or c-MYC
- A61K39/001153—Wilms tumor 1 [WT1]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001156—Tyrosinase and tyrosinase related proteinases [TRP-1 or TRP-2]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001158—Proteinases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001158—Proteinases
- A61K39/001161—Caspases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001162—Kinases, e.g. Raf or Src
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001154—Enzymes
- A61K39/001164—GTPases, e.g. Ras or Rho
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001169—Tumor associated carbohydrates
- A61K39/00117—Mucins, e.g. MUC-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00118—Cancer antigens from embryonic or fetal origin
- A61K39/001181—Alpha-feto protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001186—MAGE
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001184—Cancer testis antigens, e.g. SSX, BAGE, GAGE or SAGE
- A61K39/001188—NY-ESO
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001191—Melan-A/MART
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/00119—Melanoma antigens
- A61K39/001192—Glycoprotein 100 [Gp100]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001194—Prostate specific antigen [PSA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001193—Prostate associated antigens e.g. Prostate stem cell antigen [PSCA]; Prostate carcinoma tumor antigen [PCTA]; PAP or PSGR
- A61K39/001195—Prostate specific membrane antigen [PSMA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/0005—Vertebrate antigens
- A61K39/0011—Cancer antigens
- A61K39/001196—Fusion proteins originating from gene translocation in cancer cells
- A61K39/001197—Breakpoint cluster region-abelson tyrosine kinase [BCR-ABL]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/461—Cellular immunotherapy characterised by the cell type used
- A61K39/4615—Dendritic cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/462—Cellular immunotherapy characterized by the effect or the function of the cells
- A61K39/4622—Antigen presenting cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/46—Cellular immunotherapy
- A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
- A61K39/4643—Vertebrate antigens
- A61K39/4644—Cancer antigens
- A61K39/46448—Cancer antigens from embryonic or fetal origin
- A61K39/464482—Carcinoembryonic antigen [CEA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/14—Peptides being immobilised on, or in, an inorganic carrier
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterized by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
- A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K39/46 characterised by the dose, timing or administration schedule
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oncology (AREA)
- Cell Biology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Developmental Biology & Embryology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Reproductive Health (AREA)
- Pregnancy & Childbirth (AREA)
- Gynecology & Obstetrics (AREA)
- Gastroenterology & Hepatology (AREA)
- Inorganic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
본 발명은 산화아연-결합성 펩타이드를 포함하는 단백질과 산화아연 나노입자의 복합체, 의약의 제조를 위한 약물전달체로서의 그의 용도, 상기 복합체를 포함하는 백신 조성물 및 조영제를 제공한다. 산화아연-결합성 펩타이드를 포함하는 단백질은 산화아연 나노입자의 생체 내 활용성을 현저히 개선시키므로, 상기 복합체는 의약의 생체 내 또는 세포 내 전달을 위한 약물전달체로서 사용할 수 있을 뿐만 아니라 생체 또는 세포의 이미징을 위해 사용할 수 있으며, 생물제재를 효과적으로 분리할 수 있는 분리제, 온열치료를 비롯한 치료제, MRI 조영제, 바이오센서에 응용 가능한 비드(bead)의 제조를 위한 용도를 추가로 제공한다.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2012537814A JP5722334B2 (ja) | 2009-11-03 | 2010-11-03 | 酸化亜鉛−結合性ペプチドを含むタンパク質と酸化亜鉛ナノ粒子の複合体及びその用途 |
US13/505,705 US9718860B2 (en) | 2009-11-03 | 2010-11-03 | Complex of a protein comprising zinc oxide-binding peptides and zinc oxide nanoparticles, and use thereof |
EP10828515.6A EP2500350B1 (en) | 2009-11-03 | 2010-11-03 | Composite of a protein comprising zinc oxide-bonding peptides and zinc oxide nanoparticles, and use thereof |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2009-0105510 | 2009-11-03 | ||
KR20090105510 | 2009-11-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011055980A2 WO2011055980A2 (ko) | 2011-05-12 |
WO2011055980A3 true WO2011055980A3 (ko) | 2011-09-22 |
Family
ID=43970543
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/KR2010/007726 WO2011055980A2 (ko) | 2009-11-03 | 2010-11-03 | 산화아연-결합성 펩타이드를 포함하는 단백질과 산화아연 나노입자의 복합체 및 그의 용도 |
Country Status (5)
Country | Link |
---|---|
US (1) | US9718860B2 (ko) |
EP (1) | EP2500350B1 (ko) |
JP (1) | JP5722334B2 (ko) |
KR (1) | KR101276180B1 (ko) |
WO (1) | WO2011055980A2 (ko) |
Families Citing this family (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9597383B2 (en) | 2012-07-05 | 2017-03-21 | FullHope Biomedical Co., Ltd. | Formulation and method for preparing specific T cell, and method for preparing the formulation |
TWI503414B (zh) * | 2012-07-05 | 2015-10-11 | Fullhope Biomedical Co Ltd | 一種製備專一性t細胞之配方、方法及其配方製備方法 |
KR101413158B1 (ko) * | 2012-08-17 | 2014-07-01 | 전북대학교산학협력단 | 양자점의 표면 개질 방법과 이를 이용한 생체 광학영상화 |
CN105188772B (zh) * | 2013-04-05 | 2019-08-02 | 尹特荣生物科技株式会社 | 基于金属氧化物纳米颗粒的t1-t2双模式磁共振成像造影剂 |
WO2015111407A1 (en) | 2014-01-22 | 2015-07-30 | Kabushiki Kaisha Toyota Chuo Kenkyusho | Rare earth material-binding peptide and use thereof |
KR102001289B1 (ko) * | 2016-10-13 | 2019-07-17 | 고려대학교 산학협력단 | 산화아연 결합 펩티드 서열, 이를 포함하는 복합체, 및 상기 복합체를 포함하는 약학 조성물 |
US10398732B2 (en) | 2016-10-13 | 2019-09-03 | Marshall University Research Corporation | Compositions and methods for treating striated muscle injury, treating striated muscle atrophy and/or for promoting striated muscle growth |
LT3773689T (lt) * | 2018-04-11 | 2023-01-25 | Enterome S.A. | Antigeniniai peptidai, skirti vėžio prevencijai ir gydymui |
CN111686127B (zh) * | 2020-06-04 | 2022-02-15 | 华南理工大学 | 锌铁纳米材料在降解突变p53蛋白中的应用 |
CN113425853B (zh) * | 2021-05-08 | 2023-05-05 | 华南师范大学 | 一种谷胱甘肽修饰的靶向脑的氧化锌量子点的基因运输载体及其制备方法 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2330699A1 (en) * | 1998-04-30 | 1999-11-11 | Gyre Ltd. | Multifunctional adhesin proteins and their display in microbial cells |
US6998137B2 (en) * | 2000-04-07 | 2006-02-14 | Macromed, Inc. | Proteins deposited onto sparingly soluble biocompatible particles for controlled protein release into a biological environment from a polymer matrix |
AU2003220209A1 (en) * | 2002-03-13 | 2003-09-29 | New Century Pharmaceuticals, Inc. | Method of isolating binding peptides from a combinatorial phage display library and peptides produced thereby |
US20100233219A1 (en) * | 2006-03-30 | 2010-09-16 | Fujifilm Corporation | Inorganic nanoparticle compromising an active substance immobilized on the surface and a polymer |
JP2007269632A (ja) * | 2006-03-30 | 2007-10-18 | Fujifilm Corp | 薬物を固定化した無機ナノ粒子 |
JP5029997B2 (ja) * | 2007-02-15 | 2012-09-19 | 国立大学法人東北大学 | 酸化亜鉛結合性抗体及びその用途 |
US9714269B2 (en) * | 2008-07-04 | 2017-07-25 | Universite De Liege Interface Enterprises Universite | Inorganic-binding peptides and quality control methods using them |
US20110200534A1 (en) | 2008-08-21 | 2011-08-18 | Industry-Academic Cooperation Foundation, Yonsei U | T1-T2 Dual Modal MRI Contrast Agents |
-
2010
- 2010-11-03 US US13/505,705 patent/US9718860B2/en active Active
- 2010-11-03 KR KR1020100108877A patent/KR101276180B1/ko active IP Right Grant
- 2010-11-03 EP EP10828515.6A patent/EP2500350B1/en active Active
- 2010-11-03 JP JP2012537814A patent/JP5722334B2/ja active Active
- 2010-11-03 WO PCT/KR2010/007726 patent/WO2011055980A2/ko active Application Filing
Non-Patent Citations (4)
Title |
---|
KJAERGAARD ET AL.: "Sequestration of Zinc Oxide by Fimbrial Designer Chelators", APPLIED ENVIRONMENTAL MICROBIOLOGY, vol. 66, no. 1, 31 January 2000 (2000-01-31), pages 10 - 14, XP008156537 * |
THAI ET AL.: "Identification and Characterization of Cu20- and ZnO-Binding Polypeptides by Escherichia coli Cell Surface Display:Toward an Understanding of Metal Oxide Binding", BIOTECHNOLOGY AND BIOENGINEERING, vol. 87, no. 2, 16 June 2004 (2004-06-16), pages 129 - 137, XP002387068 * |
TOMCZAK ET AL.: "Morphological control and assembly of zinc oxide using a biotemplate", ACTA BIOMATERIALIA, vol. 5, 6 December 2008 (2008-12-06), pages 876 - 882, XP008156572 * |
UMETSU ET AL.: "Bioassisted Room-Temperature Immobilization and Mineralization of Zinc Oxide-The Structural Ordering of ZnO Nanoparticles into a Flower Type Morphology", ADVANCED MATERIALS, vol. 17, 22 September 2005 (2005-09-22), pages 2571 - 2575, XP008156544 * |
Also Published As
Publication number | Publication date |
---|---|
US20120219504A1 (en) | 2012-08-30 |
US9718860B2 (en) | 2017-08-01 |
JP2013509452A (ja) | 2013-03-14 |
EP2500350B1 (en) | 2018-08-15 |
JP5722334B2 (ja) | 2015-05-20 |
KR20110049724A (ko) | 2011-05-12 |
EP2500350A2 (en) | 2012-09-19 |
WO2011055980A2 (ko) | 2011-05-12 |
KR101276180B1 (ko) | 2013-06-18 |
EP2500350A4 (en) | 2013-06-26 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2011055980A3 (ko) | 산화아연-결합성 펩타이드를 포함하는 단백질과 산화아연 나노입자의 복합체 및 그의 용도 | |
WO2009130198A3 (en) | Hyperglycosylated human coagulation factor ix | |
EP3192526A3 (en) | Exosomes for delivery of biotherapeutics | |
EP1988928A4 (en) | MAGNETIC NANOCOMPOSITE FOR CONTRAST, INTELLIGENT CONTRAST, DRUG DELIVERY FOR SIMULTANEOUS DIAGNOSIS AND TREATMENT AND DISPOSAL FOR TARGET SUBSTANCE | |
WO2008131057A3 (en) | Sustained release formulations of opioid and nonopioid analgesics | |
JP2015530404A5 (ko) | ||
WO2008131056A3 (en) | Sustained release monoeximic formulations of opioid and nonopioid analgesics | |
IL212184A (en) | Conditional expression vector of protein (s) acting as immunomodulator (s), engineered training cells, their pharmaceutical composition and their use in drug preparation | |
WO2010083337A3 (en) | Composite nanostructures and methods for making and using them | |
IL232308A (en) | Compounds as modulators of atp-linked casting, pharmaceuticals containing them and their use in the preparation of drugs for the treatment of diseases and processes for their preparation | |
IL223783B (en) | Compound 1-converted indole for use in the treatment of a disease or condition, a pharmaceutical preparation containing the compound and use of the compound to prepare a medicine | |
JP2016500648A5 (ko) | ||
WO2010036918A3 (en) | Intracellular dna receptor | |
IL218052A (en) | Use of an erythropoietin receptor plant and protein for combination therapy to increase red blood cell levels or to treat or prevent anemia | |
WO2007002662A3 (en) | Anti-inflammatory, radioprotective, and longevity enhancing capabilities of cerium oxide nanoparticles | |
WO2011146518A3 (en) | Pegylated c-peptide | |
WO2011106309A3 (en) | Materials and methods for mri contrast agents and drug delivery | |
EP2365796A4 (en) | FUSOGENIC PROPERTIES OF SAPOSIN C AND RELATED PROTEINS AND PEPTIDES FOR APPLICATION TO TRANSMEMBRANE DRUG DELIVERY SYSTEMS | |
WO2012121528A3 (en) | Magnetic nanocomposite specific for thyroid cancer and use thereof | |
IL232325A0 (en) | 18-methyl-7,6-methylene-3-oxo-17-paragan-4-en-21, 17b-carbolactones, pharmaceutical preparations containing these compounds and their use for the treatment of endometrial disease | |
AP2957A (en) | New antibodies specific of the Beta-amyloid peptides and their uses as diagnostic agents or drugs | |
GB2496794A (en) | Combination pharmaceutical composition and methods of treating and methods of treating functional diseases or conditions of gastrointestinal tract | |
HK1258028A1 (zh) | 人類抗體及其在神經疾病治療中的診斷和治療用途 | |
WO2011143201A3 (en) | Ratiometric combinatorial drug delivery | |
WO2012083302A3 (en) | Compositions and methods for the treatment or prevention of human adenovirus-36 infection |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10828515 Country of ref document: EP Kind code of ref document: A1 |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13505705 Country of ref document: US Ref document number: 2012537814 Country of ref document: JP |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010828515 Country of ref document: EP |