WO2011022679A3 - Composés cannabinoïdes benzofurane et méthodes d'utilisation associées - Google Patents

Composés cannabinoïdes benzofurane et méthodes d'utilisation associées Download PDF

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Publication number
WO2011022679A3
WO2011022679A3 PCT/US2010/046208 US2010046208W WO2011022679A3 WO 2011022679 A3 WO2011022679 A3 WO 2011022679A3 US 2010046208 W US2010046208 W US 2010046208W WO 2011022679 A3 WO2011022679 A3 WO 2011022679A3
Authority
WO
WIPO (PCT)
Prior art keywords
benzofuran
related methods
cannabinoid compounds
compounds
receptors
Prior art date
Application number
PCT/US2010/046208
Other languages
English (en)
Other versions
WO2011022679A2 (fr
Inventor
Bob M. Ii Moore
Steven Gurley
Suni Mustafa
Original Assignee
University Of Tennessee Research Foundation, The
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University Of Tennessee Research Foundation, The filed Critical University Of Tennessee Research Foundation, The
Publication of WO2011022679A2 publication Critical patent/WO2011022679A2/fr
Publication of WO2011022679A3 publication Critical patent/WO2011022679A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4406—Non condensed pyridines; Hydrogenated derivatives thereof only substituted in position 3, e.g. zimeldine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La présente invention a pour objet des composés analogues de cannabinoïdes furanopyridine de la formule I. Les composés sont utiles pour modifier l'activité des récepteurs CB1 et CB2 et traiter des affections médiées par ces récepteurs.
PCT/US2010/046208 2009-08-20 2010-08-20 Composés cannabinoïdes benzofurane et méthodes d’utilisation associées WO2011022679A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US23550409P 2009-08-20 2009-08-20
US61/235,504 2009-08-20

Publications (2)

Publication Number Publication Date
WO2011022679A2 WO2011022679A2 (fr) 2011-02-24
WO2011022679A3 true WO2011022679A3 (fr) 2011-06-16

Family

ID=43605843

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2010/046208 WO2011022679A2 (fr) 2009-08-20 2010-08-20 Composés cannabinoïdes benzofurane et méthodes d’utilisation associées

Country Status (2)

Country Link
US (1) US8476309B2 (fr)
WO (1) WO2011022679A2 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103242273B (zh) 2012-02-09 2015-06-03 中国科学院上海药物研究所 2-芳基苯并呋喃-7-甲酰胺类化合物、其制备方法及用途
US10897925B2 (en) 2018-07-27 2021-01-26 Joseph Pandolfino Articles and formulations for smoking products and vaporizers
US20200035118A1 (en) 2018-07-27 2020-01-30 Joseph Pandolfino Methods and products to facilitate smokers switching to a tobacco heating product or e-cigarettes

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01199957A (ja) * 1988-02-04 1989-08-11 Mitsui Petrochem Ind Ltd ベンゾフラン誘導体、クロメン誘導体および医薬
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
WO2006129318A2 (fr) * 2005-05-31 2006-12-07 Pharmos Corporation Derives de benzofuranne presentant des activites therapeutiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2909754A1 (de) * 1979-03-13 1980-09-18 Thomae Gmbh Dr K Neue benzofuran- und benzothiophenderivate, deren herstellung und deren verwendung als arzneimittel
CA1281325C (fr) * 1984-06-20 1991-03-12 Patrice C. Belanger Derives de benzofurane
DK1188747T3 (da) * 1999-05-24 2006-01-23 Mitsubishi Pharma Corp Phenoxypropylaminforbindelser

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5087638A (en) * 1984-06-20 1992-02-11 Merck Frosst Canada, Inc. Benzofuran derivatives
JPH01199957A (ja) * 1988-02-04 1989-08-11 Mitsui Petrochem Ind Ltd ベンゾフラン誘導体、クロメン誘導体および医薬
WO2006129318A2 (fr) * 2005-05-31 2006-12-07 Pharmos Corporation Derives de benzofuranne presentant des activites therapeutiques

Also Published As

Publication number Publication date
WO2011022679A2 (fr) 2011-02-24
US8476309B2 (en) 2013-07-02
US20110046175A1 (en) 2011-02-24

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