WO2011018700A1 - Natural extract from whole banana fruit (musa spp.) - Google Patents

Natural extract from whole banana fruit (musa spp.) Download PDF

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Publication number
WO2011018700A1
WO2011018700A1 PCT/IB2010/001994 IB2010001994W WO2011018700A1 WO 2011018700 A1 WO2011018700 A1 WO 2011018700A1 IB 2010001994 W IB2010001994 W IB 2010001994W WO 2011018700 A1 WO2011018700 A1 WO 2011018700A1
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Prior art keywords
extract
banana
powder
natural
mammals
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PCT/IB2010/001994
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French (fr)
Inventor
Munisekhar Medasani
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Munisekhar Medasani
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Application filed by Munisekhar Medasani filed Critical Munisekhar Medasani
Priority to CN2010800343656A priority Critical patent/CN102481329A/en
Priority to CA2769758A priority patent/CA2769758A1/en
Priority to EA201270274A priority patent/EA028836B1/en
Priority to AU2010283544A priority patent/AU2010283544B2/en
Priority to US13/389,998 priority patent/US8496977B2/en
Priority to EP10808028.4A priority patent/EP2464363A4/en
Priority to JP2012524301A priority patent/JP2013501772A/en
Publication of WO2011018700A1 publication Critical patent/WO2011018700A1/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/78—Saururaceae (Lizard's-tail family)
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/111—Aromatic compounds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/142—Amino acids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/168—Steroids
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23K20/00—Accessory food factors for animal feeding-stuffs
    • A23K20/10—Organic substances
    • A23K20/184—Hormones
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/03—Products from fruits or vegetables; Preparation or treatment thereof consisting of whole pieces or fragments without mashing the original pieces
    • A23L19/07—Fruit waste products, e.g. from citrus peel or seeds
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
    • A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105—Plant extracts, their artificial duplicates or their derivatives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/02—Nutrients, e.g. vitamins, minerals
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P3/00—Drugs for disorders of the metabolism
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    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
    • Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
    • Y02P60/87—Re-use of by-products of food processing for fodder production

Definitions

  • Banana is the common name for the fruit of herbaceous plant of the family Musaceae and genus Musa. They are native to the tropical region of Southeast Asia. Bananas are mostly cultivated for the fruit and also for fiber an 1 ornamental use.
  • bananas in the world. In the developing world banana are considered as staple food. It f r ⁇ vides instant energy, rich source of fiber, minerals and vitamins. It has about 200 volatile compo ⁇ ;nts which include phyto-nutrients, sterols and fatty acids.
  • Bananas along hh a glass of whole milk are considered as staple food and provide the entire nutrient requirement for he body. This is considered as most preferred diet for dieters. Being rich source of neurotransmitter and its precursors, it provides instant mood elevation. Potassium rich bananas are good for hypertep isive people. This is the only fruit considered very safe from infants to the old age people.
  • Drugs used for ai tidepress ⁇ nt and anti-anxiety treatment mainly falls into two classes i.e. Serotonin— norepinephrine reuptake inhibitors (SNRIs) and Selective serotonin reuptake inhibitors/serotonin- specific reuptaki inhibitor (SSRIs). These drugs work by inhibiting the reuptake of the ⁇ eurotransm itters serotonin and norepinephrine. This results in an increase in the extracellular concentrations of serotonin and norepinephrine and therefore an increase in neurotransmission.
  • Serotonin norepinephrine reuptake inhibitors
  • SSRIs Selective serotonin reuptake inhibitors/serotonin- specific reuptaki inhibitor
  • Banana lectins are bein j used mainly for research purpose. Banana essence is being isolated from peels of banana, which is mainly as food additive and fragrance. Insoluble banana fiber, banana starch and banana pectin is being isolated and being used different industrial purposes.
  • Present inventio i is for whole fruit extract of banana, which includes edible portion of fruit and peel, with physical tr latment, enzymatic process and resin treatment. This innovation is for separation of
  • Nitrogen containing molecules like, but not limited to, amino acids, proteins, glyco-proteins, neurotransmitters and its precursors, minerals. This extract is characterized by very minimal or not containing sirnpl sugars and fiber.
  • BBB blood-brain- barrier
  • This extract provides the similar result like antidepressants i.e. increasing levels of neurotransmitters naturally in the body whereby providing similar effect as SSRIs and SNRIs naturally.
  • This extract is water soluble; Hence body will utilize required neurotransmitters and eliminates the excess through excretion. Oral and cytotoxicity tests conducted has shown that the extract is safe even at higher duxes.
  • Process proposed in Hie claims differs mainly in 3 aspects i.e. having minimal or no simple sugars, having minimal )r no insoluble fiber, having higher percentage of neurotransmitters (w/w) when converted into po vder foam.
  • Tt is also known i aad understood that proposed treatment with charged ion exchange resins is being used in juices/sy ⁇ s/p ⁇ ree manufacturing for clarification of juices/syrups/puree and removing minerals, proteins etc. But don stituents which collected into resin never fiad been used for purpose discussed Or claimed in this in

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  • Molecular Biology (AREA)
  • Physiology (AREA)

Abstract

Natural Extract from Whole Fruit of Banana (Musa Spp)., whether unripe or ripe, containing mainly natural Melatonin, Serotonin, Catecholamines and its precursors; amino acids tryptophan and tyrosine; mineral potassium, magnesium, phosphorous and antioxidants. Contains very minimal or no carbohydrates. Final extract is in liquid, semi solid or powder form. Extract is for mammals and animal use at doses 1 to 1,000mg in powder or equivalent to powder per day. Extract is used as nutritional supplement, medicine or adjuvant in liquid, gel, capsule, caplet or tablet form. Physical treatment, Enzymatic processes and resin extraction are mainly used for extraction. Food or pharmaceutical grade additives like preservatives or antioxidants are added for shelf life. Other extracts, vitamins, minerals and amino acids may be added for further enhancement of the effectiveness and usage. Extract is used for mammals and animals, in one or more of conditions, for mood elevation, reducing stress, anxiety and depression; increasing Basal Metabolism Rate (BMR), thermogenesis, obesity, hyperlipidemia, hypercholesterol, hypertension, diabetes, sleeping disorders, neurological disorder, muscular disorder, erectile dysfunction and to increase potassium content in the body.

Description

Natural Extract from Whole Banana Fruit (Musa Spp.)
Background:
Banana is the common name for the fruit of herbaceous plant of the family Musaceae and genus Musa. They are native to the tropical region of Southeast Asia. Bananas are mostly cultivated for the fruit and also for fiber an 1 ornamental use.
About 170 coudbies produce bananas in the world. In the developing world banana are considered as staple food. It f rυvides instant energy, rich source of fiber, minerals and vitamins. It has about 200 volatile compoπ ;nts which include phyto-nutrients, sterols and fatty acids.
Bananas along hh a glass of whole milk are considered as staple food and provide the entire nutrient requirement for he body. This is considered as most preferred diet for dieters. Being rich source of neurotransmitter and its precursors, it provides instant mood elevation. Potassium rich bananas are good for hypertep isive people. This is the only fruit considered very safe from infants to the old age people.
Traditionally it is considered good for any gastric irritations, ulcers, constipation. Its starch provides a protective layer m the stomach while its non-digestible fiber is good for cholesterol lowering and constipation. Native Africans use inner part υf banana peel for insect bites and skin problems. In Ayurveda they suggest eating of banana peel for diabetics as it is good source of potassium, but do not contain sugars w\ ich are more in the edible portion.
Ancient uses an recent studies have shown that bananas have good antioxidant properties and correcting electro yte imbalance.
Drugs used for ai tidepressαnt and anti-anxiety treatment mainly falls into two classes i.e. Serotonin— norepinephrine reuptake inhibitors (SNRIs) and Selective serotonin reuptake inhibitors/serotonin- specific reuptaki inhibitor (SSRIs). These drugs work by inhibiting the reuptake of the πeurotransm itters serotonin and norepinephrine. This results in an increase in the extracellular concentrations of serotonin and norepinephrine and therefore an increase in neurotransmission.
Description of the nvention:
For the convenier se of readers it is understood that wherever the word 'extract' mentioned in the context of inventic » i,. it refers to the extract claimed under Uiib invention. Wherever the word 'inventor' is mentioned in the context of this invention, it refers to the inventor named in this patent application.
All the traditional uses and latest inventions have used either edible portion of banana or peel for separation of flavo lotds, phenols and volatile compounds. Inventor himself applied for patents earlier for separation of natural potassium from bananas. Inventor's sear ;h on literature has revealed mainly powders, puree, syrups and juices of banana. Banana Powdeϊs contains carbohydrates more than 80%. Banana puree is mainly made out of edible portion of bana ta and used for infant food and deserts. Banana juice is mainly made of edible portion of banana and < ontains natural sugars. There are some research articles on preparation of banana wine by using enzyπ atlc process and converting sugars into alcohol by using yeast fermentation. Banana lectins are bein j used mainly for research purpose. Banana essence is being isolated from peels of banana, which is mainly as food additive and fragrance. Insoluble banana fiber, banana starch and banana pectin is being isolated and being used different industrial purposes.
Present inventio i is for whole fruit extract of banana, which includes edible portion of fruit and peel, with physical tr latment, enzymatic process and resin treatment. This innovation is for separation of
Nitrogen containing molecules like, but not limited to, amino acids, proteins, glyco-proteins, neurotransmitters and its precursors, minerals. This extract is characterized by very minimal or not containing sirnpl sugars and fiber.
Innovation and novelty is specific extraction whole banana fruit which mainly containing neurotransmitter; minerals and Nitrogen containing molecules like amino acids, proteins, glyco- proteins and anti xidants. This pure and specific extract υf banana Is effective for human consumption at as little as 1 per dose, as this extract's bioavailability of above nutrients is higher compared to eating whole ban na and nontoxic at even 1 ,000mg per dose.
Besides providinj extract with good antioxidant properties, inventor has taken care of retaining natural Norepinephrine and Epinephrine in the extract which is known for increasing body thermogenesis and energy expenditu e by burning body fat. Norepinephrine and epinephrine are the constituents in the Green Tea which are believed to have fat burning capability. Dopamine also retained in the extract, Dopamine is kno vn for mood elevation and for erectile dysfunction. Combination of dopamine and norepinephrine arc know to increase the energy levels of the body, by increasing the respiration at mitochondria Ievi I and also causing mood elevation and motivation. Another surprising result the inventor has found is, this extract is causing thermogenesis whereby it improves cold adoption and subjects are able t< withstand for sudden cold exposure.
As far as the information available to the inventor at this time, it is not known to the art to extract whole banana fruit extra t which is rich in catecholamines, antioxidants, minerals and micronutricnts which are good for mode1 elevation, destressing properties, has considerable antioxidant properties, takes care of sleeping disorders and burns body fat by increasing thermogenesis. This exrmct can be provided for usage in simple pill form which provides goodness of peel and edible portion. Thus, this invention provides a natural emedy for all the above human sufferings by a single natural extract without need to load the body with sxcess sugars, carbohydrates and fibers.
Human body main iins levels of dopamine, serυlυπin, norepinephrine in the brain through blood-brain- barrier (BBB) function. For example, intake of dopamine is converted into L-Dopa, then transported into brain , then reconverted into dopamine. With this BBB function, human body avoids any excess
Il Inflow of neurotransmitters into brain. Instead of interfering with the body's natural function, like SSRI and SNRI5 it is advised in wholistic and traditional medicine that you provide what is required by the bv>dy and it kώows how to regular the system. This extract provides that natural relief without interfering with the body natural functions.
This extract provides the similar result like antidepressants i.e. increasing levels of neurotransmitters naturally in the body whereby providing similar effect as SSRIs and SNRIs naturally. This extract is water soluble; Hence body will utilize required neurotransmitters and eliminates the excess through excretion. Oral and cytotoxicity tests conducted has shown that the extract is safe even at higher duxes.
It is also that a standardized extract with particular level of minerals or neurotransmitters can be made this extract or natural neurotransmitters can be isolated and standardized from this process or ext It is understood and claimed that this kind of standardization falls under scope of this invention.
Jt is well known that about 30% of the banana produce get wasted in the proocssing and transporting anywhere in the vorid. Some of it goes as feed to animals, but most do not This invention provides a scope to banana [farmers to process damaged bananas into a value added product, which will have national and international importance.
Process proposed in Hie claims differs mainly in 3 aspects i.e. having minimal or no simple sugars, having minimal )r no insoluble fiber, having higher percentage of neurotransmitters (w/w) when converted into po vder foam. These three additional features together make the claimed extract as novel and innovative.
Inventor himself led an earlier patent for saturation of body stores with natural potassium extracted from bananas. Thils earlier patent has been abandoned now, as present invention supersedes the benefits of earlier inventio in many ways.
Tt is also known i aad understood that proposed treatment with charged ion exchange resins is being used in juices/syπφs/pψree manufacturing for clarification of juices/syrups/puree and removing minerals, proteins etc. But don stituents which collected into resin never fiad been used for purpose discussed Or claimed in this in |ention. It may be understood that because only edible portion of banana is used for making juices/syπj ips/puree. Constituents recovered from resins in juiucs/syrups/puree manufacturing industry also falls inder the scope of this invention even though those are recovered only from edible portion of the fruit or whole fruit.
Patent Reference!
1. US 5989559 Banana peel extract composition and method for extraction
2. US 4273792 Banana Processing
3. US 4874617 Banana Processing
Figure imgf000005_0001
Figure imgf000006_0001

Claims

WHATIS CΛ.kiMEBi
1. Natural ϊxtract from whole Frυit of Banana (Musa Spp.), (including edible portion and peel), whether unripe or ripe, containing mainly natural Melatonin, Serotonin, Catecholamines and its precursc 5; amino acids tryptophan and tyrosine; minerals potassium, magnesium, phosphorous and antic xidants. Contains very minimal or no carbohydrates.
2. As claimed in claim 1, wherein natural extract contains neurotransmitters, but not limited to,
Seratonii , Melatonin, Dopamine, Norepinephrine, epinephrine or its oxidized forms.
3. As claim sd in claim I1 wherein mineral content In the extract is between 20 and 80% of weight
4. As claim Mi in claim 1, wherein carbohydrates in the extract are between 0.05% and 30% of weight
5. As claimed in claim 1, wherein pH of the extract is between 4 to 7
6. As claim* d in claim 1, wherein simple sugars in the extract are less than 10% of weight
7. As claim* i in cjaim 1, wherein starch, fiber and pectin together in the extract is less than 20% of weight
8. As claime 1 in claim 1. wherein extract is soluble in water
9. As claime 1 in claims 2 to 8, wherein extract is in powder form with less than 15% moisture content
10. As claime d in claim 1, wherein whole banana is selected from kigdom: Plantae, family:
Musaceae, Genus: Musa.
11. As claimet in claim 1, wherein extract is in powder, gel, paste, Simi-solid, liquid forms
12. As claime i in claim 1, wherein extract is for usage in mammals and animals as food supplemen , medicine, food additive, adjuvant; or adjuvant to food supplements or foods or drinks or d ink mixes or medir.iαes
13. As claimet in claim 1, wherein extract is administered to mammals and animals by orally, subcutaπeously, nasally, transdermaUy, dermally, sublingually or others or being in the form of nanoparticl is or nano gels or adsorbed on an excipient chewing proteins, and
conditions, Rate to
of
,
with
Figure imgf000008_0001
18. As clair ied in claim 17, wherein minerals, neurotransmitters, proteins, aminoacids and nitrogen contain! ig compounds like lectins and others can also be recovered by using other methods like, but not limited to, HPLC, gel columns, decanters, centrifuges, pressure filters
19. Tt is cl« tried that Minerals, neurotransmitters, proteins, aminoacids and nitrogen containing cotnpou ds like lectins and others are recovered by using resins like, but not limited to, cation resins in juice manufacturing industry, whether only edible or whole fruit is used for producing juices/sy iips/puree, are for mammal and animal use as medicines, food supplement, adjuvant or additive
20. As claim ϊd in above claims 1-19, wherein extract is for mammals and animal use at doses 1 to 1 ,000mg in powder or equivalent to powder per day
PCT/IB2010/001994 2009-08-12 2010-08-11 Natural extract from whole banana fruit (musa spp.) WO2011018700A1 (en)

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AU2010283544A AU2010283544B2 (en) 2009-08-12 2010-08-11 Natural Extract from Whole Banana Fruit (Musa Spp.)
US13/389,998 US8496977B2 (en) 2009-08-12 2010-08-11 Natural extract from whole banana fruit (Musa Spp)
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CN102633707A (en) * 2012-04-11 2012-08-15 杨公明 Method for preparing natural 5-hydroxy tryptamine hydrochloride by utilizing banana peel
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JP2015117230A (en) * 2013-11-14 2015-06-25 大谷　勝 Method for producing banana-derived composition, and biologically active substance containing banana-derived composition
US10835567B2 (en) 2017-02-10 2020-11-17 Tci Co., Ltd. Method for regulating expressions of TPH1 gene, DDC gene, and/or AANAT gene by using banana peel extract
US10905674B2 (en) 2017-11-22 2021-02-02 Tci Co., Ltd. Method of increasing melatonin synthesis to treat insomnia, ameliorate sleep disturbance and regulate sleep
CN111394496A (en) * 2020-03-26 2020-07-10 中国农业科学院油料作物研究所 Method for improving low nitrogen stress tolerance and nitrogen absorption accumulation of rape

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