CN109122856A - A kind of liver-protecting sober-up Chinese medicine composition - Google Patents

A kind of liver-protecting sober-up Chinese medicine composition Download PDF

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Publication number
CN109122856A
CN109122856A CN201810721522.9A CN201810721522A CN109122856A CN 109122856 A CN109122856 A CN 109122856A CN 201810721522 A CN201810721522 A CN 201810721522A CN 109122856 A CN109122856 A CN 109122856A
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liver
grams
food
composition
moringa
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胡海峰
孙海燕
李彻
宋玲鋆
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Co Ltd Of Health Industry Research Institute Of Traditional Chinese Medicines Group
Epr Health Industry (shenzhen) Co Ltd
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Co Ltd Of Health Industry Research Institute Of Traditional Chinese Medicines Group
Epr Health Industry (shenzhen) Co Ltd
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Priority to CN201810721522.9A priority Critical patent/CN109122856A/en
Publication of CN109122856A publication Critical patent/CN109122856A/en
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/16—Agglomerating or granulating milk powder; Making instant milk powder; Products obtained thereby
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/154—Milk preparations; Milk powder or milk powder preparations containing additives containing thickening substances, eggs or cereal preparations; Milk gels
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
    • A23C9/156—Flavoured milk preparations ; Addition of fruits, vegetables, sugars, sugar alcohols or sweeteners
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
    • A23C9/00—Milk preparations; Milk powder or milk powder preparations
    • A23C9/18—Milk in dried and compressed or semi-solid form
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/42—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds characterised by the carbohydrates used, e.g. polysaccharides
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
    • A23G3/36—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds
    • A23G3/46—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing dairy products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23G3/00—Sweetmeats; Confectionery; Marzipan; Coated or filled products
    • A23G3/34—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof
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    • A23G3/48—Sweetmeats, confectionery or marzipan; Processes for the preparation thereof characterised by the composition containing organic or inorganic compounds containing plants or parts thereof, e.g. fruits, seeds, extracts
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
    • A23L2/385—Concentrates of non-alcoholic beverages
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A23P10/00—Shaping or working of foodstuffs characterised by the products
    • A23P10/20—Agglomerating; Granulating; Tabletting
    • A23P10/28—Tabletting; Making food bars by compression of a dry powdered mixture
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23P10/30—Encapsulation of particles, e.g. foodstuff additives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/287—Chrysanthemum, e.g. daisy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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Abstract

The invention discloses a kind of liver-protecting sober-up Chinese medicine composition, the composition ingredient includes: four kinds of integration of drinking and medicinal herbs Chinese medicines such as rde bean, fructus lycii, chrysanthemum, leaf of Moringa and a kind of new raw-food material L-arabinose.Liver-protecting sober-up composition of the invention has substantially reduced alcohol to hepar damnification, acceleration of alcohol metabolism, the functions such as Quick sobering.What the present invention used is integration of drinking and medicinal herbs Chinese medicine highly-safe, that toxic side effect is small or new raw-food material, can be developed as products such as ordinary food, health foods.

Description

A kind of liver-protecting sober-up Chinese medicine composition
Technical field
The present invention relates to a kind of food or field of health care products, more particularly, to the food or health care product of liver-protecting sober-up.
Background technique
Drinking is the living habit of Chinese, the necessary beverage of even more various dinner parties；Human body is to the catabolism of alcohol A kind of normal physiological phenomenon, catabolism is acetic acid under the action of alcohol dehydrogenase and acetaldehyde dehydrogenase in liver in vivo, Finally it is metabolized as carbon dioxide and water.If human body lacks two kinds of alcohol metabolism enzymes or the vigor of enzyme is not high, liver cannot and When alcohol is decomposed, especially metabolite acetaldehyde have bigger toxicity, cause body function disorder, cause alcoholism Phenomenon.
In the mechanism of alcoholic hepatic injury, alcohol and its metabolite acetaldehyde are to the injury of liver, brain and its organ It is main；Alcoholism has been a worldwide problem, seriously affects the health of majority of populations.
Ancient Times in China has corresponding formula to various alcoholism symptoms there are many good recipe of relieving the effect of alcohol.It is contained according to ancient book, side Agent is varied, only to the statistics such as Holy Benevolent Prescriptions, " Prescriptions for Universal Relief " and treatise on Febrile Diseases, big and small more than 100 kinds of prescriptions.Previously The country developed it is a variety of sober up or disintoxicating product such as flower of kudzuvine is waken up the products such as soup for alleviating hangover, Jiu Xianle, Shigao Tang, all have certain shield Liver is sobered up effect.
L-arabinose, also known as pectinose, arabinose；It is a kind of aldopentose.L-arabinose is seldom in nature In the form of monosaccharide exist, usually with other monosaccharide ining conjunction with, be present in the form of heteroglycan colloid, hemicellulose, pectic acid, carefully In granulose and certain glucosides.It is improved people's living condition by food and medicine surveillance authority of the U.S. and Japan as a kind of sweetener low in calories It saves approval and is included in healthy food additive, representative physiological action is selectively to influence to disappear in small intestine disaccharide-hydrolysing enzymes The invertase for changing sucrose, to inhibit the absorption of sucrose.American Medical Association is included in the nutritional supplementation for being used as antiobesity agent Agent or non-prescribed medicine, in the specific health food inventory of Japanese health ministry, L-arabinose is put into for adjusting blood glucose Dedicated special food supplement.The Ministry of Public Health of China is classified as new resource food in May, 2008.L-arabinose pair Enteron aisle can play good acidizing effect, and intestinal acidity environmental benefits are in Bifidobacterium, the life of the intestine beneficial bacteria colonies such as lactic acid bacteria It is long, promote body to calcium uptake, enhance the ability of body discharge Toxic, inhibits harmful microorganism proliferation, to enhance human body Resistance.
Rde bean, alias: red bean, red rice bean, rice bean, albumen beans, Chi Shandou, Latin literary fame: Vigna umbellata (Thunb.) Ohwi et Ohashi is beans annual herb.Rde bean is mainly used for Chinese medicine, often mixed with red bean, has benefit Water detumescence section, Vigna, removing toxic substances apocenosis and other effects.Rde bean contain protein, fat, carbohydrate, crude fibre, calcium, phosphorus, The nutritional ingredients such as iron, vitamin B1, vitamin B2, saponin(e.Its nutritive effect: it is mild-natured, it is sweet in flavor, sour, energy is inducing diuresis and reducing edema (oedema, Tinea pedis, jaundice, dysentery, hematochezia, carbuncle swells), heat-clearing removing jaundice, removing toxic substances apocenosis.With good relax bowel and defecation, lowering blood pressure and blood fat, The effects of adjusting blood glucose, prevention calculus, body building and weight reducing.
Leaf of Moringa refers to the leaf for originating in the perennial tropical deciduous tree Moringa tree (also known as drumstick tree) of India, edible With, with supplementing the nutrients comprehensively, immunity is improved, toxin-expelling and face nourishing, logical intestines are convenient, lose weight and other effects.Leaf of Moringa powder is full of nutrition And it is comprehensive, vitamin E is 70 times and 40 times of spirulina and soybean powder respectively.Leaf of Moringa powder has hypoglycemic, lipid-loweringing, decompression, resists Tumour, anti-oxidant, defaecation, diuresis, expelling parasite, improvement sleep and other effects, long-term consumption can enhance immune function of human body, delay to decline Always, prevent disease.Ayurveda thinks that Moringa can prevent 300 kinds of diseases.Especially in recent years Moringa by prosperities such as America and Europes The concern of national many research institutions and consumer and heat are held in both hands.
This title of fructus lycii is first appeared in " Book of Songs " before Chinese two thousand years.Drug scholar's Li Shizhen (1518-1593 A.D.) cloud of the Ming Dynasty: " Chinese holly Qi, two tree names.The thorn of this object spine such as Chinese holly, the item of stem such as Qi, therefore and name it." fruit (Chinese medicine claims fructus lycii), main ingredient: Chinese holly Matrimony vine (betane) containing glycine betaine, atropine (atropine), hyoscyamine (gyoscyamine).Polysaccharides is a kind of water Soluble polysaccharide is most important active constituent in fructus lycii.It there is now a lot research shows that polysaccharides has promotion immune, anti-ageing Always, the effects of antitumor, removing free radical, antifatigue, anti-radiation, liver protection, reproductive function protection and improvement.Glycine betaine: chemistry Entitled 1- carboxy-N, N, N- betaine is similar to amino acid in chemical structure, belongs to quaternary amine alkaloids. Fructus lycii is mainly due to caused by contained glycine betaine to lipid-metabolism or lipotropic effect, it plays methyl supply in vivo The effect of body.Wolfberry pigment: wolfberry pigment is all kinds of present-color materials being present in fructus lycii berry, is the important physiology of fructus lycii seed Active constituent.Main includes-carrotene, lutein and other coloring matters.Carotenoid contained by fructus lycii then has non- Often important medical value.Verified fructus lycii seed pigment has raising immune function of human body, prevention and inhibits swollen for many researchs The effects of tumor and prevention of arterial atherosis.
Chrysanthemum (Classification system: Dendranthema morifolium (Ramat.) Tzvel.): it is in Plant Taxonomy Composite family, Chrysanthemum perennial herb plant.Feverfew property is pungent, sweet, bitter, slightly cold.Return lung, Liver Channel.Effect dispelling wind and heat from the body is put down Liver improving eyesight, it is clearing heat and detoxicating.For anemopyretic cold, fever and headache, red eyes and dim-sighted, kidney deficiency and liver, mesh is secretly dim-sighted, and dizziness infantile convulsion is controlled Liver-yang hyperactivity, headache and dizziness are apt to dispelling wind and heat, clearing liver-fire, and energy benefiting yin improving eyesight, therefore can be used and control in wind-heat of liver channel or irascibility Caused red eye, swell pain is attacked, the benefits of long memorial wind clears liver and improve vision is total to；It is clearing heat and detoxicating, outstanding kind solution serious case of furuncle, therefore can be used and control furuncle swelling toxin.
Chinese patent CN101797023A discloses application of the L-arabinose as Medicament for Alcoholism, finds it in research process The activity of alcohol dehydrogenase and acetaldehyde dehydrogenase, acceleration of alcohol metabolic process, when alleviation alcohol is put aside in human body can be enhanced Between long cause harm to the human body.
Chinese patent CN102058047A discloses a kind of guarantor of alleviation alcoholic liver being made of L-arabinose, Mixed Microbes Health food innovatively combines L-arabinose, Mixed Microbes, solves in Antialcoholic liver-protecting health care product in the prior art and solve bartender The effect of liver not prominent question.But Mixed Microbes are added in the technical solution, it is especially high to manufacturing technique requirent, and to product matter Amount requirement is also relatively high, and product needs low-temperature storage, shelf-life short, increases cost indirectly.
Chinese patent CN201510154071 discloses a kind of composition of protect liver restoring consciouness, mainly by L-arabinose and Chinese holly The effect of Qi chrysanthemum is combined, and reaches liver protection and eyesight, and restoring consciouness is detoxified, has certain characteristic and advantage.But its diuresis effect compared with Difference, alcohol and its metabolite drainage difficulty, it may appear that some side reactions.
Object of the present invention is to advanced optimize formula combination on the basis of L-arabinose, fructus lycii, chrysanthemum composition, increase Its inducing diuresis and reducing edema (oedema, tinea pedis, jaundice, dysentery, hematochezia, carbuncle swells), heat-clearing removing jaundice, removing toxic substances apocenosis, extra-nutrition, raising is added to exempt from It is convenient and other effects to lead to intestines for epidemic disease power.It is screened by a large amount of zooperies, discovery the composition has more preferably superior liver-protecting sober-up function Effect, and side reaction is less.
Summary of the invention
In order to overcome the shortcomings of L-arabinose, the fructus lycii, chrysanthemum composition of prior inventions, inventor passes through a large amount of animals Experiment screening, it was found that a kind of new composition has preferably synergistic effect, can not only improve alcohol metabolism enzyme degradation wine Essence can be reduced alcohol residence time in vivo, be substantially reduced alcohol and its generation with the excretion of acceleration of alcohol and its metabolite Thank to product to hepar damnification.The raw material that the present invention uses is new raw-food material or integration of drinking and medicinal herbs material, and safety is good, Ke Yichang Phase is edible.
The present invention provides a kind of composition of liver-protecting sober-up, includes following component: L-arabinose according to mass percent 10-45%, rde bean 10-30%, leaf of Moringa 10-20%, fructus lycii 5-25%, chrysanthemum 5-25%；
It preferably, include following component: L-arabinose 20-40%, rde bean 20-30% according to mass percent meter, Leaf of Moringa 10-20%, fructus lycii 10-20%, chrysanthemum 10-20%；
It is furthermore preferred that including following component: L-arabinose 30-44%, rde bean 20- according to mass percent meter 25%, leaf of Moringa 15-20%, fructus lycii 15-20%, chrysanthemum 15-20%.
Liver-protecting sober-up composition provided by the invention can also be added protection gastric mucosa and correct the milk powder of bitter taste.
Preferably, the mass percent of the milk powder in the composition are as follows: 0-20% is more selected as 15-20%.
Liver-protecting sober-up composition provided by the invention, also include common food auxiliary material and food additives, food auxiliary material and Mass percent 10-20% shared by additive, preferably 15-20%.
Liver-protecting sober-up composition provided by the invention, the tablet are prepared by the following method: L-arabinose 100-400 Gram, 0-300 grams of red bean powder, 0-300 grams of leaf of Moringa powder, 50-250 grams of medlar powder, 50-250 grams of chrysanthemum powder, milk powder 100- 200 grams, 100-200 grams of microcrystalline cellulose；Through mixing granulation, the tablet or pressed candy is made in tabletting machine.
The present invention also provides a kind of liver-protecting sober-up compositions to apply in the food or health care product for preparing liver-protecting sober-up.
Agents useful for same and raw material are commercially available available in the present invention.
Except other explanation, rde bean of the present invention includes rde bean medicinal material, the prepared slices of Chinese crude drugs, red bean powder or its extraction Object；The leaf of Moringa includes leaf of Moringa medicinal material, the prepared slices of Chinese crude drugs, leaf of Moringa powder or its extract；The fructus lycii include medicinal material, The prepared slices of Chinese crude drugs, wolfberry fruit powder and its extract；The chrysanthemum is that feverfew includes feverfew medicinal material, the prepared slices of Chinese crude drugs, feverfew pollen And its extract.
The positive effect of the present invention is that: not only rationality designs liver-protecting sober-up composition provided by the invention, also There are a large amount of zoopery garbled datas, it was demonstrated that its synergistic action effect is good；Not only medicinal material is raw-food material, and safety is good, matches Side is also fairly simple, is easy to quality control, it is important to can reach more relieving alcoholism and protecting liver effect.
Specific embodiment
The present invention is further illustrated below by embodiment, but not therefore only invention is limited in scope of embodiments, under Experimental method is not specified in the embodiment of face is routine experiment method, is operated according to product manual.
The embodiment of liver-protecting sober-up Chinese medicine composition:
The prescription of 1 embodiment 1-7 of table
Embodiment 1
Weigh 100 grams of L-arabinose, 300 grams of rde bean, 100 grams of leaf of Moringa, 100 grams of fructus lycii, 100 grams of chrysanthemum, milk powder 200 grams and 100 grams of microcrystalline cellulose, 40 meshes are crossed respectively, and above-mentioned material addition plasmid pot is uniformly mixed.With capsule filler No. 0 capsule of encapsulating, that is, be made capsule.
Embodiment 2
Weigh 200 grams of L-arabinose, 300 grams of rde bean, 100 grams of leaf of Moringa, 150 grams of fructus lycii, 50 grams of chrysanthemum, milk powder 100 grams and 100 grams of microcrystalline cellulose, 40 meshes are crossed respectively, and above-mentioned material addition plasmid pot is uniformly mixed.Aluminium foil bag dispenses Obtain solid beverage.
Embodiment 3
Weigh 300 grams of L-arabinose, 200 grams of rde bean, 100 grams of leaf of Moringa, 100 grams of fructus lycii, 100 grams of chrysanthemum, milk powder 100 grams and 100 grams of microcrystalline cellulose, 40 meshes are crossed respectively, and above-mentioned material addition plasmid pot is uniformly mixed.Aluminium foil bag dispenses Obtain solid beverage.
Embodiment 4
Weigh 200 grams of L-arabinose, 100 grams of rde bean, 200 grams of leaf of Moringa, 50 grams of fructus lycii, 200 grams of chrysanthemum, milk powder 100 grams and 150 grams of microcrystalline cellulose, 40 meshes are crossed respectively, and above-mentioned material addition plasmid pot is uniformly mixed.Through tabletting machine Up to tablet.
Embodiment 5
Weigh 400 grams of L-arabinose, 100 grams of rde bean, 100 grams of leaf of Moringa, 250 grams of fructus lycii, 50 grams of chrysanthemum, milk powder 0 Gram and 100 grams of microcrystalline cellulose, respectively cross 40 meshes, by above-mentioned material addition plasmid pot be uniformly mixed.Through tablet press machine large size mould Has tabletting up to pressed candy.
Embodiment 6
Weigh 400 grams of L-arabinose, 100 grams of rde bean, 100 grams of leaf of Moringa, 250 grams of fructus lycii, 50 grams of chrysanthemum, milk powder 0 Gram and 100 grams of microcrystalline cellulose, respectively cross 40 meshes, by above-mentioned material addition plasmid pot be uniformly mixed.Through tablet press machine large size mould Has tabletting up to pressed candy.
Embodiment 7
Weigh 400 grams of L-arabinose, 0 gram of rde bean, 0 gram of leaf of Moringa, 150 grams of fructus lycii, 150 grams of chrysanthemum, 100 grams of milk powder With 200 grams of microcrystalline cellulose, respectively cross 40 meshes, by above-mentioned material addition plasmid pot be uniformly mixed.Through tablet press machine large size mould Tabletting is up to pressed candy.
Embodiment 8: liver-protecting sober-up effect test
Below by way of mouse test, liver-protecting sober-up effect is carried out to the sample of embodiment 1-7 and is evaluated,
Drug and reagent
L-arabinose, dehydrated alcohol (analyze pure, Sinopharm Chemical Reagent Co., Ltd.), commercially.
Test composition is prepared respectively according to embodiment 1-7
Experimental animal:
ICR mouse, animal rank: cleaning grade is provided by Shanghai western Poole-Bi Kai experimental animal Co., Ltd
Dose design and give drug solns prepare:
Control group: 0.95 gram of L-arabinose is weighed, distilled water is added to be configured to 7.5ml aqueous solution
Administration group 1: 0.95 gram of example 1 group mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 2: 2 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 3: 3 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 4: 4 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 5: 5 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 6: 6 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Administration group 7: 7 groups of embodiment, 0.95 gram of mixture is weighed, distilled water is added to be configured to 7.5ml solution
Male ICR mouse 90 of 19-20 grams of weight are taken, random point 9 groups, every group 10, respectively model group, control Group, administration 1-7 group.After mouse is deprived of food but not water 12 hours, model group stomach-filling distilled water, other groups give corresponding medical fluid, stomach-filling 0.2ml/10 grams of volume.After 30 minutes, 50% ethanol solution of each group intragastric administration on mice (0.16ml/10 grams).Mouse is recorded to after drinking To there is righting reflex loss (i.e. drunk time)；Righting reflex restores (sobering up the time), compares each group mice drunk and sobers up Situation.
The different prescription mice drunks of table 2 and situation of sobering up
Group Number of animals (only) Drunk time (min) Sober up the time (min)
Model group 10 14.85±12.56 280.00±30.75
Control group 10 19.35±14.51 235.12±35.35
It is administered 1 group 10 28.25±14.16 201.10±25.15
It is administered 2 groups 10 31.35±13.52 197.05±12.34
It is administered 3 groups 10 32.85±17.32 185.12±18.24
It is administered 4 groups 10 35.85±14.22 180.00±24.14
It is administered 5 groups 10 39.26±13.56 177.15±22.25
It is administered 6 groups 10 42.45±16.26 170.12±19.35
It is administered 7 groups 10 27.45±11.36 210.00±25.71
Can be seen that administration 1-7 group according to the above experimental data has protection to a certain degree to make hepatic injury caused by ethyl alcohol With shortening is sobered up the time, has anti-alcohol function；It is good that 1-6 group compares L-arabinose control group effect, also compares L- Arab Sugar, fructus lycii chrysanthemum group effect are good.Therefore, new Chinese medicine composition has the function of more preferably liver-protecting sober-up.

Claims (9)

1. a kind of liver-protecting sober-up composition, which is characterized in that include following ingredient: L-arabinose 10- according to mass percent 45%, rde bean 10-30%, leaf of Moringa 10-30%, fructus lycii 5-25%, chrysanthemum 5-25%.
2. liver-protecting sober-up composition as described in claim 1 includes following ingredient: L-arabinose 20- according to mass percent 40%, rde bean 20-30%, leaf of Moringa 10-20%, fructus lycii 10-20%, chrysanthemum 10-20%.
3. liver-protecting sober-up composition as described in claim 1 includes following ingredient: L-arabinose according to mass percent 30-40%, rde bean 20-25%, leaf of Moringa 15-20%, fructus lycii 15-20%, chrysanthemum 15-20%.
4. liver-protecting sober-up composition a method according to any one of claims 1-3, it is characterised in that also contain milk powder, according to quality percentage Than including 0-20%, preferably 15-20%.
5. the liver-protecting sober-up composition as described in claim 1-4 is any, it is characterised in that also added containing food auxiliary material or food Agent.
6. the liver-protecting sober-up composition as described in claim 1-5 is any, it is characterised in that contained food auxiliary material or food additives Shared mass percent 10-20%, preferably 15-20%.
7. a kind of use composition as claimed in any one of claims 1 to 6 to eat for the food of liver-protecting sober-up made of raw material or health care Product.
8. food as claimed in claim 7 or health food, the food or health food can be solid beverage, tablet, Capsule or pressed candy.
9. food as claimed in claim 8 or health food, the tablet or pressed candy are prepared by the following method: L- I 100-400 grams of uncle's sugar, 100-300 grams of red bean powder, 100-300 grams of leaf of Moringa powder, 50-250 grams of medlar powder, chrysanthemum powder 50- 250 grams, 0-200 grams of milk powder, 100-200 grams of microcrystalline cellulose；Through mixing granulation, the tablet or pressure is made in tabletting machine Piece candy.
CN201810721522.9A 2018-07-05 2018-07-05 A kind of liver-protecting sober-up Chinese medicine composition Pending CN109122856A (en)

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