WO2011012217A3 - Copräzipitate umfassend einen phosphodiesterase-5-inhibitor (pde-5-inhibitor) und einen pharmazeutisch verträglichen trägerstoff, ihre herstellung und verwendung - Google Patents
Copräzipitate umfassend einen phosphodiesterase-5-inhibitor (pde-5-inhibitor) und einen pharmazeutisch verträglichen trägerstoff, ihre herstellung und verwendung Download PDFInfo
- Publication number
- WO2011012217A3 WO2011012217A3 PCT/EP2010/004181 EP2010004181W WO2011012217A3 WO 2011012217 A3 WO2011012217 A3 WO 2011012217A3 EP 2010004181 W EP2010004181 W EP 2010004181W WO 2011012217 A3 WO2011012217 A3 WO 2011012217A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- inhibitor
- phosphodiesterase
- precipitate
- pde
- production
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Pain & Pain Management (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Die vorliegende Erfindung betrifft ein Copräzipitat, umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Copolymer-Trägerstoff bestehend aus 2 oder mehr verschiedenen Acrylsäurederivaten, Verfahren zur Herstellung desselben sowie ein Arzneimittel, umfassend das erfindungsgemäße Copräzipitat, Verfahren zur Herstellung dieses Arzneimittels und die Verwendung dieses Arzneimittels zur Behandlung einer Krankheit, bei der Inhibierung von Phosphodiesterase-5 von therapeutischem Nutzen ist.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP10730104A EP2459174A2 (de) | 2009-07-29 | 2010-07-08 | Copräzipitate umfassend einen phosphodiesterase-5-inhibitor (pde-5-inhibitor) und einen pharmazeutisch verträglichen trägerstoff, ihre herstellung und verwendung |
US13/387,276 US20120189694A1 (en) | 2009-07-29 | 2010-07-08 | Co-precipitate comprising a phosphodiesterase-5 inhibitor (pde-5-inhibitor) and a pharmaceutically compatible carrier, production and use thereof |
EA201270206A EA022037B1 (ru) | 2009-07-29 | 2010-07-08 | Копреципитат, включающий ингибитор фосфодиэстеразы-5 (pde-5-ингибитор) и фармацевтически совместимый носитель, его получение и применение |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102009035211.2 | 2009-07-29 | ||
DE102009035211A DE102009035211A1 (de) | 2009-07-29 | 2009-07-29 | Copräzipitate umfassend einen Phosphodiesterase-5-Inhibitor (PDE-5-Inhibitor) und einen pharmazeutisch verträglichen Trägerstoff, ihre Herstellung und Verwendung |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2011012217A2 WO2011012217A2 (de) | 2011-02-03 |
WO2011012217A3 true WO2011012217A3 (de) | 2012-04-26 |
Family
ID=42646808
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2010/004181 WO2011012217A2 (de) | 2009-07-29 | 2010-07-08 | Copräzipitate umfassend einen phosphodiesterase-5-inhibitor (pde-5-inhibitor) und einen pharmazeutisch verträglichen trägerstoff, ihre herstellung und verwendung |
Country Status (5)
Country | Link |
---|---|
US (1) | US20120189694A1 (de) |
EP (1) | EP2459174A2 (de) |
DE (1) | DE102009035211A1 (de) |
EA (1) | EA022037B1 (de) |
WO (1) | WO2011012217A2 (de) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE102007028869A1 (de) | 2007-06-22 | 2008-12-24 | Ratiopharm Gmbh | Verfahren zur Herstellung eines Arzneimittels enthaltend Tadalafil |
WO2014202797A1 (en) * | 2013-07-05 | 2014-12-24 | Synthon B.V. | Pharmaceutical composition comprising a solid dispersion of tadalafil |
EP3082428A4 (de) | 2013-12-09 | 2017-08-02 | Respira Therapeutics, Inc. | Pde5-inhibitorpulverformulierungen und zugehörige verfahren |
SI3466951T1 (sl) * | 2014-07-23 | 2022-05-31 | Krka, D.D., Novo Mesto | Proces za pripravo zaviralca CGMP-fosfodiesteraze in oralne farmacevtske formulacije, ki obsega koprecipitate tadalafila |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038131A1 (en) * | 1995-06-02 | 1996-12-05 | Glaxo Group Limited | Method of producing a solid dispersion of a poorly water soluble drug |
EP1875914A1 (de) * | 2006-07-07 | 2008-01-09 | Teva Pharmaceutical Industries Ltd. | Feste Zusammensetzungen, die Tadalafil und wenigstens eine Trägersubstanz enthalten |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0297866A3 (de) * | 1987-07-01 | 1989-12-13 | The Boots Company PLC | Arzneimittel |
GB9311920D0 (en) | 1993-06-09 | 1993-07-28 | Pfizer Ltd | Therapeutic agents |
GB9423910D0 (en) | 1994-11-26 | 1995-01-11 | Pfizer Ltd | Therapeutic agents |
US6548490B1 (en) | 1997-10-28 | 2003-04-15 | Vivus, Inc. | Transmucosal administration of phosphodiesterase inhibitors for the treatment of erectile dysfunction |
UA71629C2 (en) | 1999-08-03 | 2004-12-15 | Lilli Icos Llc | Composition containing free drug particulate form of ?-carboline (variants), method for its manufacture (variants), and method for treating sexual dysfunction |
SK287869B6 (sk) | 1999-08-03 | 2012-02-03 | Icos Corporation | Beta-carboline pharmaceutical compositions |
US20030139384A1 (en) | 2000-08-30 | 2003-07-24 | Dudley Robert E. | Method for treating erectile dysfunction and increasing libido in men |
US20080226723A1 (en) * | 2002-07-05 | 2008-09-18 | Celonova Biosciences, Inc. | Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same |
US20090004281A1 (en) * | 2007-06-26 | 2009-01-01 | Biovail Laboratories International S.R.L. | Multiparticulate osmotic delivery system |
US9233078B2 (en) * | 2007-12-06 | 2016-01-12 | Bend Research, Inc. | Nanoparticles comprising a non-ionizable polymer and an Amine-functionalized methacrylate copolymer |
-
2009
- 2009-07-29 DE DE102009035211A patent/DE102009035211A1/de not_active Withdrawn
-
2010
- 2010-07-08 WO PCT/EP2010/004181 patent/WO2011012217A2/de active Application Filing
- 2010-07-08 EP EP10730104A patent/EP2459174A2/de not_active Ceased
- 2010-07-08 EA EA201270206A patent/EA022037B1/ru not_active IP Right Cessation
- 2010-07-08 US US13/387,276 patent/US20120189694A1/en not_active Abandoned
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996038131A1 (en) * | 1995-06-02 | 1996-12-05 | Glaxo Group Limited | Method of producing a solid dispersion of a poorly water soluble drug |
EP1875914A1 (de) * | 2006-07-07 | 2008-01-09 | Teva Pharmaceutical Industries Ltd. | Feste Zusammensetzungen, die Tadalafil und wenigstens eine Trägersubstanz enthalten |
Also Published As
Publication number | Publication date |
---|---|
WO2011012217A2 (de) | 2011-02-03 |
US20120189694A1 (en) | 2012-07-26 |
EA201270206A1 (ru) | 2012-07-30 |
DE102009035211A8 (de) | 2011-05-19 |
DE102009035211A1 (de) | 2011-02-17 |
EA022037B1 (ru) | 2015-10-30 |
EP2459174A2 (de) | 2012-06-06 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
WO2008075068A3 (en) | Acylaminopyrazoles as fgfr inhibitors | |
WO2008025857A3 (en) | New method for the treatment of inflammatory diseases | |
WO2009084024A3 (en) | A process for the preparation of r-sit agliptin and its pharmaceutically acceptable salts thereof | |
EP2027028A4 (de) | Lasche, werkzeug zur herstellung der lasche sowie verfahren zur herstellung der lasche | |
JO2858B1 (en) | Pharmaceutical dosage images | |
UA104613C2 (en) | Alkylamine-substituted dicyanopyridines and amino acid ester prodrugs thereof | |
GEP20135919B (en) | Benzoic acid (1-phenyl-2-pyridin-4-yl) ethyl esters as phosphodiesterase inhibitors | |
WO2008011131A3 (en) | Amide compounds | |
WO2009066326A3 (en) | Improved process for the preparation of prasugrel and its pharmaceutically acceptable salts | |
WO2012076466A3 (de) | Substituierte 1-benzylcycloalkylcarbonsäuren und ihre verwendung | |
ZA201001015B (en) | (Carboxylalkylene-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament | |
IL204556A0 (en) | (cyclopropyl-phenyl)-phenyl-oxalamides, method for the production thereof, and use of same as a medicament | |
WO2007115620A3 (de) | Neuartige cyclobutyl-verbindungen als kinase-inhibitoren | |
WO2007139992A3 (en) | ALDOSTERONE SYNTHASE AND/OR 11β-HYDROXYLASE INHIBITORS | |
AU2009306733C1 (en) | Sulfoximine-substituted anilinopyrimidine derivatives as CDK inhibitors, the production thereof, and use as medicine | |
IL216967A0 (en) | 17-hydroxy-17-pentafluorethyl-estra-4,9(10)-dien-11-aryl derivatives, method of production thereof and use thereof for the treatment of diseases | |
EP2479225A4 (de) | Neuartige verwendung eines lipolyseenzyms zur formung einer fingerabdruckresistenten beschichtung, substrat mit der in diesem verfahren geformten fingerabdruckresistenten beschichtung und produkte mit dem substrat | |
IN2012DN01273A (de) | ||
WO2008145842A3 (fr) | Dérivés de triazolopyridine-carboxamides, leur préparation et leur application en thérapeutique | |
UA100544C2 (ru) | Гидроксилированный пиримидилциклопентан как ингибитор протеинкиназы акт | |
WO2011012217A3 (de) | Copräzipitate umfassend einen phosphodiesterase-5-inhibitor (pde-5-inhibitor) und einen pharmazeutisch verträglichen trägerstoff, ihre herstellung und verwendung | |
UA100545C2 (ru) | Гидроксилированные пиримидил циклопентаны как ингибиторы протеинкиназы акт | |
MY173491A (en) | Therapeutic or prophylactic agent for biliary tract diseases | |
WO2010115125A3 (en) | Composition of 2,4,6-trifluoro-n-[6-(1-methyl-piperidin-4-carbonyl)-pyridin-2-yl]-benzamide | |
UA112764C2 (uk) | Оптимізований синтез чистих, неполіморфних кристалічних жовчних кислот із заданим розміром частинок |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 10730104 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2010730104 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 201270206 Country of ref document: EA |
|
WWE | Wipo information: entry into national phase |
Ref document number: 13387276 Country of ref document: US |