WO2010143767A1

WO2010143767A1 - Composition for preventing and relieving hyperlipidemia comprising extracts of citrus tangerina peel, diospyrus kaki thunb., a chinese matrimony vine, and fagopyrum esculentum leaves and method of manufacturing same

Info

Publication number: WO2010143767A1
Application number: PCT/KR2009/003371
Authority: WO
Inventors: 복성해; 최명숙; 박영민
Original assignee: (주)바이오뉴트리젠
Priority date: 2009-06-11
Filing date: 2009-06-23
Publication date: 2010-12-16
Also published as: KR20100133133A

Abstract

The present invention relates to a method of manufacturing a composition for preventing and relieving hyperlipidemia comprising extracts of Citrus tangerina peel, Diospyrus kaki Thunb., Chinese matrimony vines, and Fagopyrum esculentum leaves, and more particularly to a method for manufacturing a composition for preventing and relieving hyperlipidemia, which can reduce the content of neutral fat as well as total blood cholesterol due to active ingredients contained in Citrus tangerina peel, Diospyrus kaki Thunb., Chinese matrimony vines, and Fagopyrum esculentum leaves. The composition for preventing and relieving hyperlipidemia of the present invention containing the extracts of Citrus tangerina peel, Diospyrus kaki Thunb., Chinese matrimony vines, and Fagopyrum esculentum leaves do not cause side effects due to the use of only natural materials and reduces the content of neutral fat as well as total blood cholesterol. Therefore, the composition can be used in treating hyperlipidemic patients.

Description

Hyperlipidemia prevention and improvement composition comprising tangerine peel, persimmon, wolfberry and buckwheat leaf extract and method for producing same

The present invention relates to a composition and a method for preventing and improving hyperlipidemia containing tangerine peel, persimmon, wolfberry and buckwheat leaf extract, and more particularly in the blood due to the active ingredients contained in the tangerine peel, persimmon, wolfberry and buckwheat leaf The present invention relates to a composition and a method for preventing and improving hyperlipidemia, which can reduce not only total cholesterol but also triglyceride content.

Hyperlipidemia is a condition in which fat, such as cholesterol, triglycerides and low density lipoprotein (LDL), is abnormally increased in the blood. Total cholesterol, triglycerides, or both are elevated.

Hyperlipidemia is not usually symptomatic in itself, but if there is a lot of fat in the blood, it can stick to the walls of blood vessels, causing arteriosclerosis, which can lead to coronary heart disease, cerebrovascular disease, and peripheral vascular obstruction.

As a treatment for hyperlipidemia, it is recommended to reduce the intake of foods containing a lot of cholesterol or saturated fatty acids and to reduce the intake of calories, exercise and drug therapy.

However, diet and exercise therapy are difficult to carry out strict management and implementation, and the effect is often limited. In addition, the antihyperlipidemic agent has an effect of lowering cholesterol and triglyceride content, but has side effects such as hepatotoxicity, gastrointestinal disorder and carcinogenicity.

Accordingly, the development of functional foods that are safe for the human body and can prevent or improve hyperlipidemia without side effects have been actively made.

It is pointed out that excessive consumption of fat not only causes obesity, but also increases the risk of developing hyperlipidemia, accompanying arteriosclerosis, fatty liver, and the like.

Increased risk of developing circulatory disease due to excessive intake of fat, particularly cholesterol, is generally known, and the need for managing serum cholesterol levels has been mentioned. However, a correlation between blood triglyceride levels and the number of deaths from coronary artery disease has since been recognized and reported to be stronger than cholesterol. In addition, reports continue to support this, demonstrating that triglyceride levels are a risk factor for atherosclerosis.

The present inventors have filed a patent application confirming that citrus peel extracts rich in hesperidin, hesperetin, naringin and naringenin reduce blood cholesterol. (Korean Patent Publication No. 2001-0015512)

The present inventors continued the research based on the patented filed technology, and completed the present invention by confirming that the extracts of persimmon, wolfberry and buckwheat leaf reduced not only blood cholesterol but also triglyceride content.

Accordingly, an object of the present invention is to provide a composition and a method for producing and preventing hyperlipidemia, including a plant extract, which can reduce not only total cholesterol in the blood but also triglyceride content without side effects.

The above object of the present invention,

Preparing a mixture by mixing 90 to 110 parts by weight of persimmon, 90 to 110 parts by weight of goji berries and 30 to 40 parts by weight of buckwheat leaf, based on 100 parts by weight of tangerine;

Adding 5 times to 15 times water based on the total amount of the mixture to the mixture to extract the extract twice by 100 times at 100 ° C. for 2 to 10 hours;

Filtration and concentration of the extract under reduced pressure; And

Preparing an extract by freeze drying or spray drying the extract concentrated under reduced pressure;

It is achieved by a method for producing a composition for preventing and improving hyperlipidemia comprising a.

In addition, the above object of the present invention,

It is achieved by a composition for preventing and improving hyperlipidemia prepared by the above method.

Hyperlipidemia prevention and improvement composition comprising tangerine, persimmon, goji berry and buckwheat leaf extract according to the present invention has no side effects by using only natural ingredients, it has the effect of reducing the total cholesterol content as well as blood total cholesterol. Therefore, it can be usefully used in treating hyperlipidemia patients.

Hereinafter, the present invention will be described in detail.

In the present specification, the term "hyperlipidemia" refers to a state in which fat metabolism such as triglyceride (TG) and total cholesterol (Total Cholesterol: TC) is not properly performed, and thus the amount of fat in the blood is increased.

Hyperlipidemia prevention and improvement extract according to the present invention,

90 to 110 parts by weight per 100 parts by weight of tangerine, 90 to 110 parts by weight of goji berry and 30 to 40 parts by weight of buckwheat leaf were added at a temperature of 100 ° C. by adding 5 to 15 times water based on the total amount of the mixture. The extract can be repeatedly extracted twice by hot water extraction for 2 hours to 10 hours, filtered and concentrated under reduced pressure. Yield is 18 to 22%.

Extracts of the invention can be prepared in powder form by additional procedures such as freeze drying or spray drying.

The tangerine, persimmon, wolfberry and buckwheat leaf are preferably washed and then dried and used for preparing the extract.

As for the tangerine of this invention, it is preferable to use the peel of the pollution-free tangerine grown without using pesticide.

The tangerine is known to have a variety of pharmacological activity, for example, lipid metabolism-improving effect, anticancer and antiviral action associated with cardiovascular disease. Hesperidin from hesperidin or hesperidin, which is included in the tangerine, has been shown to be effective in capillary potentiation, decreased permeability, lowered blood pressure, lowered blood cholesterol, anti-platelet aggregation, anti-inflammatory and antiviral effects. Known.

In addition, naringin (naringin) contained in the tangerine or naringenin obtained by removing glycosides from naringin is known to lower cholesterol, anti-cancer ulcers (protection from alcohol).

The persimmon of this invention may use either a persimmon fruit or a persimmon leaf.

According to the herbaceous tree and synonym of the persimmons, it has been recorded that it helps digestion, strengthens the organs, and has pharmacological effects such as hemostasis, relieving asthma, hangover, intestinal action, tonic action, etc. It is also reported to be effective in preventing adult diseases. These effects on persimmons are evaluated by the effects of catechin, kaempherol, quercetin and tannin contained in persimmon. The persimmon is preferably mixed 90 to 110 parts by weight with respect to 100 parts by weight of tangerine, and when mixed with more than 110 parts by weight, there is a problem that the synergistic increase pattern of hyperlipidemia improving efficacy achieved by each active ingredient is weakened, 90 weight There is a problem that the effective ingredient of the persimmon is insignificant if it is mixed less than a part.

The wolfberry of the present invention may use any of wolfberry fruit or wolfberry leaves.

The wolfberry (Lycium chinense) is known to have a hypoglycemic action, lowering cholesterol concentration and hepatocyte protection. These effects on the wolfberry are evaluated by the effects of betaine (betaine) contained in the wolfberry.

The wolfberry is preferably mixed 90 to 110 parts by weight with respect to 100 parts by weight of tangerine, there is a problem that the synergistic increase pattern of hyperlipidemia improving efficacy achieved by each active ingredient is weakened when mixed with more than 110 parts by weight, 90 If the mixture is less than the weight part, there is a problem that the active ingredient of the wolfberry is insignificant.

Buckwheat leaf of the present invention is known to have a cholesterol lowering action, blood sugar lowering action. These effects on the buckwheat leaf are evaluated by the rutin contained in the buckwheat leaf.

The buckwheat leaf is preferably mixed 30 to 40 parts by weight with respect to 100 parts by weight of tangerine, there is a problem that the synergistic increase pattern of hyperlipidemia improving efficacy achieved by each active ingredient is weakened when mixed with more than 40 parts by weight, If the mixture is less than 30 parts by weight, the active ingredient of the buckwheat leaf has a slight problem.

Compositions containing the extract of tangerine, persimmon, goji berry and buckwheat leaf according to the present invention as an active ingredient can be administered orally or orally by dividing the amount of 3 to 10 g 1 to 3 times a day for adults. It is to be understood that the dosage for a particular patient should be determined in light of several relevant factors such as the weight, age, sex, health condition, diet, time of administration, method of administration, severity of the disease, etc. In no way is the present invention limited to a scope.

In addition, the composition comprising the extract of tangerine, persimmon, goji berry and buckwheat leaf according to the present invention as an active ingredient can be used for the purpose of preventing and improving hyperlipidemia, and may be used as a pharmaceutical, functional food, health food or food additives. . The composition may be prepared as a warning agent, granules, powders, syrups, solutions, liquid extracts, emulsions, suspensions, tablets, injections, spirits, capsules or pills.

Hereinafter, the present invention will be described in more detail with reference to Examples. However, these Examples are only illustrative of the present invention, and the scope of the present invention is not limited to these.

Example 1

1 kg of tangerine, 1 kg of persimmon, 1 kg of wolfberry, and 350 g of buckwheat leaf were washed, dried, 30 kg of water was added thereto, extracted twice at 100 ° C. for 5 hours, and then filtered to remove debris. The collected extract was concentrated under reduced pressure for 5 hours in a concentration tank at a temperature of 25 ° C. and a pressure of 740 mm Hg, and the concentrate was lyophilized for 48 hours in a freeze dryer maintained at a temperature of −40 ° C. to prepare a desired extract sample.

Experimental Example 1

The hyperlipidemic effect of the extract prepared in Example 1 was confirmed in hyperlipidemic patients.

Patients with hyperlipidemia were selected to take 4.5 g of the extract of Example 1 twice daily, on an empty stomach, and measured total cholesterol and triglycerides before and after taking, and the results are shown in Table 1 below.

Table 1

number	gender	age	Medication days (dose start-dose date)	Total cholesterol (TC) change (mg / dl) / decrease rate	Triglyceride (TG) change / mg rate
One	male	28	6th (2008.12.01.-12.06.)	294 → 228/22%	346 → 269/22%
2	male	39	26th (2008.11.14.-12.09.)	229 → 168/27%	217 → 190/12%
3	male	44	15th (2008.12.02.-12.16.)	251 → 211/16%	348 → 153/56%
4	male	56	6th (2008.12.15.-12.20.)	131 → 124/5%	404 → 114/72%
5	male	58	20th (2008.12.01.-12.20.)	198 → 122/38%	347 → 149/57%
6	male	68	23rd (2008.12.01.-12.23.)	195 → 162/17%	179 → 162/9%
7	female	53	7th (2008.12.12.-12.18.)	178 → 142/20%	528 → 168/68%
8	female	57	8th (2008.12.17.-12.24.)	274 → 273/0%	250 → 158/37%
Average value / average rate of decline				219 → 179/18%	327 → 170/48%

As can be seen in Table 1, as a result of taking the extract of the present invention twice daily, 6 days to 26 days to eight adult male and female hyperlipidemia patients, total cholesterol was lowered in seven except one Triglycerides had a lowering effect in all eight patients. In particular, it can be seen that the extract of the present invention has a great effect in lowering the content of triglycerides.

In particular, the present invention is not clinically tested in experimental animals, clinical trials in patients with hyperlipidemia, it is meaningful that the total cholesterol in the blood as well as the content of triglycerides can be reduced.

Claims

Preparing a mixture by mixing 90 to 110 parts by weight of persimmon, 90 to 110 parts by weight of goji berries and 30 to 40 parts by weight of buckwheat leaf, based on 100 parts by weight of tangerine;

Adding 5 times to 15 times water based on the total amount of the mixture to the mixture to extract the extract twice by 100 times at 100 ° C. for 2 to 10 hours;

Filtration and concentration of the extract under reduced pressure; And

Preparing an extract by freeze drying or spray drying the extract concentrated under reduced pressure;

Method for producing a composition for preventing and improving hyperlipidemia comprising a.
The method of claim 1,

Hyperlipidemia prevention and improvement composition prepared by the above method.