WO2010086515A1 - Plaque implantable pour la refection de parois - Google Patents
Plaque implantable pour la refection de parois Download PDFInfo
- Publication number
- WO2010086515A1 WO2010086515A1 PCT/FR2009/001066 FR2009001066W WO2010086515A1 WO 2010086515 A1 WO2010086515 A1 WO 2010086515A1 FR 2009001066 W FR2009001066 W FR 2009001066W WO 2010086515 A1 WO2010086515 A1 WO 2010086515A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- protuberances
- textile support
- plate
- filaments
- plate according
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
-
- D—TEXTILES; PAPER
- D04—BRAIDING; LACE-MAKING; KNITTING; TRIMMINGS; NON-WOVEN FABRICS
- D04B—KNITTING
- D04B21/00—Warp knitting processes for the production of fabrics or articles not dependent on the use of particular machines; Fabrics or articles defined by such processes
- D04B21/10—Open-work fabrics
- D04B21/12—Open-work fabrics characterised by thread material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2250/00—Special features of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2250/0058—Additional features; Implant or prostheses properties not otherwise provided for
- A61F2250/0096—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers
- A61F2250/0098—Markers and sensors for detecting a position or changes of a position of an implant, e.g. RF sensors, ultrasound markers radio-opaque, e.g. radio-opaque markers
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2403/00—Details of fabric structure established in the fabric forming process
- D10B2403/02—Cross-sectional features
- D10B2403/021—Lofty fabric with equidistantly spaced front and back plies, e.g. spacer fabrics
- D10B2403/0213—Lofty fabric with equidistantly spaced front and back plies, e.g. spacer fabrics with apertures, e.g. with one or more mesh fabric plies
-
- D—TEXTILES; PAPER
- D10—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B—INDEXING SCHEME ASSOCIATED WITH SUBLASSES OF SECTION D, RELATING TO TEXTILES
- D10B2509/00—Medical; Hygiene
- D10B2509/08—Hernia repair mesh
Definitions
- the present invention relates to a prosthetic plate that is to say a plate that is implantable for the repair of walls, particularly in the treatment of hernias.
- the term "plate” is generally used to designate a flexible part made of a biocompatible and generally porous material, which part is used for making a prosthesis, in particular intended to reinforce a defective wall.
- the prosthesis itself can be made from a single plate as in the document FR.2.712.177, or from two plates as in the documents US.A.4.769.038 and EP.0.836.838 or even three plates as in EP.A.0.719.527.
- the plate itself may be formed of a single layer, especially a single-thickness fabric as in the document FR.2.712.177 or be composed of several layers as in EP.1.567.205.
- Document FR.2.776.179 discloses a composite surgical plate, which comprises a smooth inner layer and a rough outer layer, the roughness of said layer being intended to allow the attachment of organic tissues to compensate for the relative sliding effects of the plate and adjacent tissues.
- the outer layer is preferably a non-woven fibrous textile layer, in particular made of biocompatible polyamide or polypropylene yarns. It is stated in this document, that such an outer layer allows good colonization by the organic tissues in contact with the plate.
- the plaintiff is of the opinion that the simple structure of the outer layer, namely a non-woven fibrillar structure, is not likely to prevent displacement of the plate in the period following implantation and which precedes the tissue colonization.
- WO03 / 099160A1 discloses a medical implant which comprises an embossed film optionally associated with a base structure which can be textile. Admittedly, it is mentioned in this document that the bosses formed in this film can be designed to increase or reduce the friction of the implant in the body, which can be used either for fixing the implant or to increase its mobility. . But no indication is given as to the particular structure of the film which makes it possible to obtain such an increase or reduction of the friction.
- the implantable plate of the present invention comprises a textile support and has protuberances. It is characterized in that the protuberances are formed in the textile support itself, on at least one of its faces.
- the face of the textile support which comprises the protuberances comes into contact with the organic tissues and the protuberances which are constituted by the fibers or filaments of the textile support form as many areas of friction between the plate and said tissues, creating frictional forces preventing movement of said plate relative to said tissue.
- the protuberances have a conical configuration, such a configuration facilitating the penetration of the protuberances in the organic tissues. This configuration is however not exclusive, the protuberances may have in particular an undulating or cylindrical shape.
- the textile support comprises perforations, which are mainly intended to promote the drainage of body fluids and possibly to promote tissue colonization in the case where the structure itself of the textile support is not sufficiently open.
- these perforations are arranged at the level of the protuberances so that the contours of the perforation form ridges which increase the friction effect of the protuberance itself.
- the perforation is an orifice centered on this axis.
- the presence of the perforation in fact makes the protuberance has the shape of a truncated cone.
- the textile support consists at least in part of thermoplastic fibers or filaments and each protuberance is formed in a given zone of the textile support by deformation of the support structure and heat-sealing of at least some of said fibers. or filaments of said zone.
- the protuberance may be formed inside a peripheral portion, in particular an annular portion, of said zone in which said fibers or filaments are heat-welded.
- the thermo-welding of the fibers or filaments constituting the peripheral portion provides said portion with a certain rigidity, which makes it possible to form the protuberance by pushing outwardly of the plane of the textile support and thus by deforming the structure of the textile support formed fibers or filaments not heat-welded, which is inside said peripheral portion.
- the textile support comprises perforations, these are centered with respect to the peripheral portion of the determined zone.
- the protrusion is formed by deformation and heat sealing of all the fibers or filaments of the determined area of the textile support.
- the deformation is effected by stamping between two complementary tools, male and female, having the desired configuration for the protuberance and the heat-sealing is performed by applying, using the same tools, a treatment suitable for heat-sealing the fibers or deformed filaments during stamping.
- a treatment suitable for heat-sealing the fibers or deformed filaments during stamping there is, initially, deformation of the initial structure of the textile support, in particular the displacement of the fibers or filaments with respect to each other until the desired configuration for the protuberance is obtained, and there is, in a second time, heat-sealing fibers or filaments in their new arrangement.
- the at least superficial melting of the fibers or filaments which is developed during the heat-sealing operation brings a certain rigidity to all the fibers or filaments of the protuberance, which increases its frictional properties and therefore the antimigratory character of the plate.
- Thermo-welding thermoplastic fibers or filaments is carried out in particular by ultrasound.
- the textile support is a nonwoven which is thermo-bonded by points.
- the textile support is a fabric of the 3D or three-dimensional type, consisting of two layers connected by connecting threads.
- weaving it is obtained by superposition of a sheet of warp threads and several plies of weft threads or by superposition of several plies of warp threads and weft threads.
- the connection of these different plies is ensured either by some of the warp son of at least one of the warp son plies of the superposition or by an additional sheet of warp son, said binding chain.
- By knitting it is obtained on a loom double chain needle, in which the connection of the two respectively knitted layers on each needle bed is provided by an additional chain ply which works alternately on one and the other bedbugs.
- At least some protuberances comprise days capable of allowing the cellular colonization of the implant at the level of said protuberances and also a certain drainage of the body fluids. This makes it possible to avoid forming perforations in the textile support.
- the protuberances are formed by pushing back the fibers or filaments constituting the textile support, during this operation, a relative displacement of some of the fibers or of some of the filaments that can create days in at least some protuberances is obtained.
- the presence or absence of one or more days in a protuberance, the size and configuration of each day are rather * random parameters since they depend not only on the structure, more or less open, the textile support but also the the location, on the textile support, of the zone where the tools creating the protuberance act locally. If the structure of the textile support is relatively closed and the tools operate in an area where there is a high density of fibers or filaments, the protuberance may not contain a day. On the contrary, the protuberance will be perforated if the structure of the textile support is itself perforated and the tools act in an area already having at least a portion of day.
- a three-dimensional fabric obtained by knitting, as mentioned above, which has a perforated character is chosen as textile support. more pronounced and master this openwork character more easily than that obtained by weaving.
- the plate of the present invention may have protrusions on one side or on both sides.
- the plate comprises, on both sides of the textile support, protuberances whose height is substantially equal to or greater than the thickness (e) of said support, preferably less than three times said thickness, in particular of the order of twice said thickness. If the thickness exceeds three times the thickness of the textile support, there is a risk of aggressiveness of the fibers or filaments which constitute said protuberances.
- protuberances are regularly distributed, staggered and alternating from one face to the other, at the rate of 0.5 to 2 protuberances / cm 2 .
- the annular zone had an internal diameter of the order of 2 at 5 mm and a width of the order of 0.5 mm.
- the textile support is impregnated, for example coHagene which promotes cell colonization or polyurethane, said impregnation being able to confer on the plate a certain shape memory.
- the purpose is to allow the plate to be wound on itself for its introduction into a trocar and to deploy spontaneously when released from the trocar.
- the textile support comprises on one of its faces an anti-adherent coating, in particular on the face having no antimigratory protuberances.
- non-stick coating is meant a coating which is able to avoid or at least to strongly limit the adhesions between the plate and the parts of the body against which it comes into contact, once implanted, especially the viscera. It may be a coating of collagen, polysaccharide or other resorbable biopolymer or not. The implantation of any prosthesis must be able to be followed by the surgeon, so as to verify the behavior of the prosthesis over time.
- the prosthesis consists of a single-thickness fabric resulting from a weaving or knitting of polyester stranded yarns so as to form an airy structure with square or rectangular meshes.
- polyester son are combined in a warp and / or weft with metal son.
- the presence of metal son in the prosthetic plate can be a disadvantage, especially because it increases the rigidity thereof and increases its manufacturing cost.
- the prosthetic plate of the present invention comprises a radiopaque marking on all or part of the surface of the textile support.
- this radiopaque marking results from the localized impregnation of the textile support with a silicone composition comprising a radiopaque filler, in particular a filler of barium sulfate or tantalum.
- the marking is in the form of lines to form a regular grid.
- the pitch of the grid is between 2 and 45 mm, preferably of the order of 15 mm.
- FIG. 1 is a diagrammatic representation in plan view of a prosthetic plate portion having two frustoconical protuberances
- FIG. 2 is a diagrammatic representation in section of the prosthetic plate of FIG. 1 along the plane H-II 1
- FIG. 3 is a diagrammatic representation in plan view of a prosthetic plate having protuberances in relief on its two faces;
- FIG. 4 is a schematic representation in plan view of the plate of FIG. 3 comprising a radiopaque marking; in the form of a grid passing between the protuberances, and
- Figure 5 is a microscope photograph illustrating a protuberance formed in a three-dimensional knit.
- the prosthetic plate 1 intended for the repair of walls, in particular in the hernia area, comprises a textile support 2 of which at least one of the faces 2a is surmounted by anti-migratory protuberances 3 formed at from the fibers or filaments making up the textile support itself. It is the fibers or filaments which, coming into direct contact with the organic tissues, confer on said protuberances an anti-migratory effect, preventing the migration of the plate 1 once it has been implanted by the surgeon without being fixed with in any way, whether by mechanical means such as staples or sutures or by any other means.
- the textile support 2 is, in the first example which will be described, a nonwoven, formed by the entanglement of fibers or thermoplastic filaments which are joined to each other by bonding, more precisely by spot thermobonding, obtained by passing a layer of fibers or filaments between two engraved heating cylinders. It is in particular a nonwoven fabric of 45 to 100 g / m 2 , made from polypropylene filaments. In this example the binding has a density of 36 points / cm 2 , each point being of the order of 0.1 mm 2 .
- each protuberance 3 has the shape of a truncated cone, the small open base of the truncated cone corresponding to a perforation 4, that is to say a through hole, formed in the textile support 2.
- the angle ⁇ of inclination of the truncated cone, with respect to the general plane of the textile support 2, is of the order of 45 ° in the example illustrated in FIG. is not limiting. In the case where this angle ⁇ is 90 °, the protuberance then has a configuration which is not frustoconical but cylindrical.
- the protuberances 3 could possibly be formed during the manufacture of the textile support 2. However for simplification they are formed on the textile support already made by pushing outwardly along the arrow F of Figure 2 the constituent fibers or filaments of said support 2 in a localized area 5.
- this localized zone 5 has been circumscribed by a peripheral portion, in particular an annular portion 6 in which the constituent fibers or filaments of the textile support 2 have been heat-welded, in particular by ultrasound.
- the fibers or filaments which are heat-welded in said portion 6 do not tend to move when pushing along the arrow F fibers or non-heat-sealed filaments which are inside this peripheral portion 6
- the thermo-welding provides a certain consolidation of the textile support around each protrusion 3. This consolidation effect, allowing only the fibers or filaments of the localized zone 5 to move to form the protuberance 3, is obtained whatever the shape. of the peripheral zone, that this one has the form of a ring as in the illustrated example or any other form.
- the configuration of the protuberance 3 is, in this case, a function of the tool used to push or stamp the textile support 2 in the localized zone 5.
- this configuration may be frustoconical as in the illustrated example, cylindrical even conical if there is no perforation 4 or wave, forming a wave effect having not an axis of symmetry as for frustoconical, conical or cylindrical configurations but a plane of symmetry.
- the perforations 4, made in the textile support 2 have the primary function of facilitating on the one hand the drainage of body fluids coming into contact with the plate and on the other hand the tissue colonization of the plate, in particular when the latter has a microporous structure, as is the case of a thermo-bonded nonwoven. It is this colonization which makes it possible to obtain a definitive fixation of the plate 1 within a period which is generally fifteen days after implantation.
- the second function of these perforations is to increase, by the edges that they form when they are arranged at the level of the protuberances 3, as many complementary points of friction, contributing to the anti-migratory effect of the protuberances themselves.
- the prosthetic plate 1 of Figure 1 is for example obtained in two successive steps.
- the first step consists, starting from a large textile support, in two simultaneous operations of cutting and punching by stamping.
- the cutting operation makes it possible to give the plate 1 its external dimensions, for example a rectangle of 17 cm ⁇ 15 cm.
- the perforation operation makes it possible to make as many through-holes as there are perforations 4 desired in number and size, for example circular perforations of the order of 1 to 2 mm in diameter, with 0.5 to 2 perforations. / cm 2 .
- the second step consists of two simultaneous ultrasonic thermo-welding operations according to the annular portion 6 and embossing of the textile support inside this annular portion 6.
- an ultrasonic tool comprising a male part and a female part.
- the prosthetic plate is placed on the female part.
- the male part comprises as many unit sonotrodes as perforations, each unit sonotrode bearing on the prosthetic plate in the annular portion and having a central extension forming embossing tip.
- the placement of the prosthetic plate 2 on the female part is such that each perforation 4 is centered relative to to a ring annular sonotrode and its embossing tip.
- the unit sonotrodes carry out the localized fusion of the fibers or filaments of the prosthetic prosthesis in the annular portion 6 and the embossing tip deforms the structure of the textile support at interior of this annular portion 6, displacing the non-heat-sealed fibers or filaments to form the protuberances 3.
- each protuberance is, in the example illustrated in FIG. 2, substantially of the order of the thickness e of the prosthetic plate 2. In practice this height h is preferably of the order of twice this thickness e, not normally greater than three times this thickness e to avoid the risk of aggression with regard to organic tissues.
- the plate 1 is provided with anti-migratory protrusions on both sides.
- the same tool can be used to form the annular zones and the protuberances on both sides in two successive steps, the first to form the protuberances and the annular zones. corresponding to said protuberances on one side and the second to form the protuberances and corresponding annular areas on the other side, after reversal of the textile support.
- FIG. 3 shows an exemplary embodiment of a prosthetic plate 11, the textile support 12 of which is provided on its upper face 12a with protuberances 13. Each protuberance 13 is delimited by a peripheral portion 16 and has a central perforation 14. This same prosthetic plate 11 has, on its other internal face 12b, protuberances
- the protuberances 13, 23 are regularly distributed in staggered and alternating of one face 12a to the other 12b.
- the protuberances 13, 23 form parallel alignments both longitudinal and transverse, these alignments being offset from one face to the other by a distance which is equal to half of the spacing between two adjacent protuberances.
- the protuberances 13, 23 have substantially the same height h.
- FIG. 4 shows a plate 31 which comprises on its two faces protuberances 13, 23 identical to those of the example of FIG. 3.
- This prosthetic plate 31 furthermore comprises a radiopaque marking 36 which is intended to allow radiological monitoring of the prosthetic plate 31 after implantation. This follow-up must make it possible to check the correct positioning of the plate during the period preceding the fixation by tissue colonization.
- plaque control over time is made possible by performing comparative radiographs and measuring the intervals of the radiopaque frame, allowing in particular to evaluate a possible movement of the plate during its aging.
- the radiological follow-up must also make it possible to locate the location of the plate for a new intervention on another pathology requiring the surgical passage by the area where said plate is located. Finally it must allow the study, by a simple and inexpensive examination, of a revolution in the time of the textile support in terms of retraction and aging, in particular the comparative study of the radio-opaque frame allows, in case of recurrence, to better understand the cause.
- the radiopaque marking is in the form of lines 33, 34 to form a regular grid.
- the pitch P of the grid is between 2 and 45 mm, preferably of the order of 15 mm for a rectangular plate 17 cm x 15 cm.
- the lines 33,34 pass between the protuberances 13, 23; this is not, however, limiting.
- the radiopaque marking itself can in particular be obtained by localized impregnation, according to the grid lines or according to any other pattern of the textile support (32), with a silicone composition comprising a radiopaque filler, which load may in particular be barium sulphate or tantalum.
- the grid 32 is formed of longitudinal lines 33 and transverse lines 34 delimiting squares 35, each square containing one or two protuberances 13, 23.
- the grid 32 occupies the entire surface of the plate 31.
- the textile support 41 of the plate 40 is a fabric of the 3D or three-dimensional type, consisting of two layers connected by connecting threads 42 obtained by knitting on a craft double chain needle bed.
- it was made from polyester multi-filaments for the two layers 43 and polyester monofilaments with respect to the connecting threads 42. It has a macroporous structure honeycomb with hexagonal mesh forming regular days or pores 44.
- the technique of formation of the protuberances is the same as that described above, except that there are no perforations formed in the textile support 41 prior to the formation of the protuberances and that heat-sealing occurs on all the fibers or filaments in the determined area where the protuberance will be formed.
- This is obtained by stamping and heat sealing using two complementary tools, male and female, having the desired configuration for the protrusion, with or without peripheral portion.
- the heat-sealing is performed by applying an ultrasonic treatment, using these two tools, which are in this case sonotrodes, on the fibers or filaments which are deformed and compressed between the two male and female tools.
- the protuberance 45 comprises, on its substantially frustoconical wall, days 46 which result at least in part from the deformation, in particular the elongation, of the days 44 existing in the structure of the 3D knit 41, deformation which intervenes during the drawing of said knit 41 by the male embossing tool.
- days 46 allow the tissue colonization of the plate 41 at the level of the protuberances 45 themselves, which are most immediately in contact with the organic tissues.
- the anchoring of the plate 40 due to tissue colonization is faster than if this colonization did not occur at the level of the protuberances 45 but only at the other days 44 of the three-dimensional knit 41.
- All the protuberances do not comprise not necessarily days and days present in the protuberances do not all have the same size and the same configuration since it depends on the structure of the textile support in the determined area in which intervenes in a random manner the action of the pushing tools for form the protuberance.
- the largest dimension of the days in each protrusion can be of the order of 1 to 1.5 mm.
- the textile support may include an impregnation the purpose of which is to give the plate a certain shape memory, allowing it to be wound on itself for its introduction into a trocar and to be deployed spontaneously when released from the trocar. .
- It may be an impregnation of collagen, which has the advantage of accelerating tissue colonization. It can also be a polyurethane impregnation.
- the textile support may also comprise on one of its faces an anti-adherent coating, in particular on the face that does not include antimigratory protuberances.
- anti-adherent coating is meant a coating which is able to avoid or at least to strongly limit the adhesions between the plate and the parts of the body against which it comes into contact, once implanted, especially the viscera. It may be a coating of collagen, polysaccharide or other resorbable biopolymer or not.
- the formation of the protuberances as described above can be performed either on the textile support alone before impregnation or before coating or respectively on the already impregnated textile support or on the textile support already coated with its coating.
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Transplantation (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Textile Engineering (AREA)
- Prostheses (AREA)
- Finishing Walls (AREA)
Abstract
Description
Claims
Priority Applications (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL09736440T PL2391299T3 (pl) | 2009-01-30 | 2009-09-04 | Płytka możliwa do wszczepiania dla rekonstrukcji ścianek |
JP2011546899A JP2012516174A (ja) | 2009-01-30 | 2009-09-04 | 壁状構造体を再構築するための移植可能プレート |
EP09736440.0A EP2391299B1 (fr) | 2009-01-30 | 2009-09-04 | Plaque implantable pour la réfection de parois |
ES09736440.0T ES2665927T3 (es) | 2009-01-30 | 2009-09-04 | Placa implantable para la reparación de paredes |
DK09736440.0T DK2391299T3 (en) | 2009-01-30 | 2009-09-04 | IMPLANTABLE PLATE FOR WALL RECONSTRUCTION |
US13/147,026 US9421078B2 (en) | 2009-01-30 | 2009-09-04 | Implantable plate for reconstruction of walls |
BRPI0924224A BRPI0924224B8 (pt) | 2009-01-30 | 2009-09-04 | placa implantável para reparo de parede |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR0950600 | 2009-01-30 | ||
FR0950600A FR2941616B1 (fr) | 2009-01-30 | 2009-01-30 | Plaque implantable pour la refection de parois |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2010086515A1 true WO2010086515A1 (fr) | 2010-08-05 |
Family
ID=40602192
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR2009/001066 WO2010086515A1 (fr) | 2009-01-30 | 2009-09-04 | Plaque implantable pour la refection de parois |
Country Status (11)
Country | Link |
---|---|
US (1) | US9421078B2 (fr) |
EP (1) | EP2391299B1 (fr) |
JP (1) | JP2012516174A (fr) |
BR (1) | BRPI0924224B8 (fr) |
DK (1) | DK2391299T3 (fr) |
ES (1) | ES2665927T3 (fr) |
FR (1) | FR2941616B1 (fr) |
HU (1) | HUE036641T2 (fr) |
PL (1) | PL2391299T3 (fr) |
PT (1) | PT2391299T (fr) |
WO (1) | WO2010086515A1 (fr) |
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WO2012158590A1 (fr) * | 2011-05-13 | 2012-11-22 | Atex Technologies, Inc. | Tamis chirurgical avec pore stabilisé en dimensions |
WO2013111877A1 (fr) * | 2012-01-27 | 2013-08-01 | テルモ株式会社 | Textile solide, son procédé de fabrication et implant utilisant du textile solide |
DE102012005978A1 (de) | 2012-03-23 | 2013-09-26 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
WO2014184190A1 (fr) * | 2013-05-14 | 2014-11-20 | Johnson & Johnson Medical Gmbh | Implant chirurgical pourvu d'une couche comportant des ouvertures |
US10188493B2 (en) | 2011-05-13 | 2019-01-29 | Atex Technologies, Inc. | Surgical mesh with dimensionally stabilized pore |
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KR101420988B1 (ko) | 2005-10-13 | 2014-07-17 | 신세스 게엠바하 | 약물-함침 용기 |
US20130331928A1 (en) * | 2008-11-13 | 2013-12-12 | Chen Yang | Dialysis Graft with Thromboses Prevention Arrangement |
FR2962646B1 (fr) | 2010-07-16 | 2012-06-22 | Sofradim Production | Prothese avec element radio-opaque |
FR2972626B1 (fr) | 2011-03-16 | 2014-04-11 | Sofradim Production | Prothese comprenant un tricot tridimensionnel et ajoure |
FR2977790B1 (fr) | 2011-07-13 | 2013-07-19 | Sofradim Production | Prothese pour hernie ombilicale |
FR2977789B1 (fr) | 2011-07-13 | 2013-07-19 | Sofradim Production | Prothese pour hernie ombilicale |
US20130057655A1 (en) | 2011-09-02 | 2013-03-07 | Wen-Yueh Su | Image processing system and automatic focusing method |
US9005308B2 (en) | 2011-10-25 | 2015-04-14 | Covidien Lp | Implantable film/mesh composite for passage of tissue therebetween |
TWI590843B (zh) | 2011-12-28 | 2017-07-11 | 信迪思有限公司 | 膜及其製造方法 |
FR2985170B1 (fr) | 2011-12-29 | 2014-01-24 | Sofradim Production | Prothese pour hernie inguinale |
US10206769B2 (en) | 2012-03-30 | 2019-02-19 | Covidien Lp | Implantable devices including a film providing folding characteristics |
FR2992662B1 (fr) | 2012-06-28 | 2014-08-08 | Sofradim Production | Tricot avec picots |
FR2992547B1 (fr) | 2012-06-29 | 2015-04-24 | Sofradim Production | Prothese pour hernie |
FR2994185B1 (fr) | 2012-08-02 | 2015-07-31 | Sofradim Production | Procede de preparation d’une couche poreuse a base de chitosane |
FR2995788B1 (fr) | 2012-09-25 | 2014-09-26 | Sofradim Production | Patch hemostatique et procede de preparation |
FR2995779B1 (fr) | 2012-09-25 | 2015-09-25 | Sofradim Production | Prothese comprenant un treillis et un moyen de consolidation |
BR112015032045B1 (pt) | 2013-06-21 | 2020-06-09 | Depuy Synthes Products Inc | corpo flexível, método para formar um filme multicamadas para uso em combinação com um dispositivo médico implantável, sistema de armazenamento de filme e sistema para tratamento ortopédico |
EP3059255B1 (fr) | 2015-02-17 | 2020-05-13 | Sofradim Production | Méthode pour préparer une matrice de chitosane comprenant un élément de renfort fibreux |
EP3085337B1 (fr) | 2015-04-24 | 2022-09-14 | Sofradim Production | Prothèse pour supporter une structure mammaire |
ES2676072T3 (es) | 2015-06-19 | 2018-07-16 | Sofradim Production | Prótesis sintética que comprende un tejido de punto y una película no porosa y método para formarla |
EP3195830B1 (fr) | 2016-01-25 | 2020-11-18 | Sofradim Production | Prothèse de réparation de hernie |
EP3312325B1 (fr) | 2016-10-21 | 2021-09-22 | Sofradim Production | Méthode pour la fabrication un treillis avec suture crantée attachée et treillis ainsi obtenu |
EP3398554A1 (fr) | 2017-05-02 | 2018-11-07 | Sofradim Production | Prothèse pour réparation de hernie inguinale |
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- 2009-09-04 JP JP2011546899A patent/JP2012516174A/ja active Pending
- 2009-09-04 PL PL09736440T patent/PL2391299T3/pl unknown
- 2009-09-04 HU HUE09736440A patent/HUE036641T2/hu unknown
- 2009-09-04 EP EP09736440.0A patent/EP2391299B1/fr active Active
- 2009-09-04 US US13/147,026 patent/US9421078B2/en active Active
- 2009-09-04 BR BRPI0924224A patent/BRPI0924224B8/pt active IP Right Grant
- 2009-09-04 DK DK09736440.0T patent/DK2391299T3/en active
- 2009-09-04 PT PT97364400T patent/PT2391299T/pt unknown
- 2009-09-04 WO PCT/FR2009/001066 patent/WO2010086515A1/fr active Application Filing
- 2009-09-04 ES ES09736440.0T patent/ES2665927T3/es active Active
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EP1384450A1 (fr) * | 2002-07-21 | 2004-01-28 | Aesculap Ag | Implant plat à usage chirurgical |
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WO2012158590A1 (fr) * | 2011-05-13 | 2012-11-22 | Atex Technologies, Inc. | Tamis chirurgical avec pore stabilisé en dimensions |
JP2014522264A (ja) * | 2011-05-13 | 2014-09-04 | エイテックス テクノロジーズ インコーポレイテッド | 寸法安定化小孔を有する外科用メッシュ |
US10188493B2 (en) | 2011-05-13 | 2019-01-29 | Atex Technologies, Inc. | Surgical mesh with dimensionally stabilized pore |
WO2013111877A1 (fr) * | 2012-01-27 | 2013-08-01 | テルモ株式会社 | Textile solide, son procédé de fabrication et implant utilisant du textile solide |
DE102012005978A1 (de) | 2012-03-23 | 2013-09-26 | Johnson & Johnson Medical Gmbh | Chirurgisches Implantat |
WO2013139482A1 (fr) | 2012-03-23 | 2013-09-26 | Johnson & Johnson Medical Gmbh | Implant chirurgical |
US9949815B2 (en) | 2012-03-23 | 2018-04-24 | Johnson & Johnson Gmbh | Surgical implant |
WO2014184190A1 (fr) * | 2013-05-14 | 2014-11-20 | Johnson & Johnson Medical Gmbh | Implant chirurgical pourvu d'une couche comportant des ouvertures |
RU2670683C2 (ru) * | 2013-05-14 | 2018-10-24 | Джонсон Энд Джонсон Медикал Гмбх | Хирургический имплантат для лечения дефекта ткани или мышечной стенки, способ производства приподнятых участков в имплантате и способ производства имплантата |
RU2670683C9 (ru) * | 2013-05-14 | 2018-12-13 | Джонсон Энд Джонсон Медикал Гмбх | Хирургический имплантат для лечения дефекта ткани или мышечной стенки, способ производства приподнятых участков в имплантате и способ производства имплантата |
Also Published As
Publication number | Publication date |
---|---|
JP2012516174A (ja) | 2012-07-19 |
ES2665927T3 (es) | 2018-04-30 |
US9421078B2 (en) | 2016-08-23 |
BRPI0924224B1 (pt) | 2019-10-15 |
FR2941616A1 (fr) | 2010-08-06 |
FR2941616B1 (fr) | 2012-06-08 |
PL2391299T3 (pl) | 2018-08-31 |
DK2391299T3 (en) | 2018-04-23 |
EP2391299A1 (fr) | 2011-12-07 |
HUE036641T2 (hu) | 2018-07-30 |
EP2391299B1 (fr) | 2018-01-17 |
BRPI0924224A2 (pt) | 2016-01-26 |
US20120016388A1 (en) | 2012-01-19 |
BRPI0924224B8 (pt) | 2021-06-22 |
PT2391299T (pt) | 2018-04-23 |
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