WO2010067913A1 - Procédé d'élimination du groupe protecteur triphénylméthane - Google Patents

Procédé d'élimination du groupe protecteur triphénylméthane Download PDF

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Publication number
WO2010067913A1
WO2010067913A1 PCT/KR2008/007364 KR2008007364W WO2010067913A1 WO 2010067913 A1 WO2010067913 A1 WO 2010067913A1 KR 2008007364 W KR2008007364 W KR 2008007364W WO 2010067913 A1 WO2010067913 A1 WO 2010067913A1
Authority
WO
WIPO (PCT)
Prior art keywords
triphenylmethane
protection group
group
resin
compound
Prior art date
Application number
PCT/KR2008/007364
Other languages
English (en)
Inventor
Jae Won Kim
Young Gwan Cha
Hyung Chul Ryu
Sun Joo Kim
Original Assignee
Pharmacostech Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacostech Co., Ltd. filed Critical Pharmacostech Co., Ltd.
Priority to JP2011534364A priority Critical patent/JP5575783B2/ja
Priority to EP08878772A priority patent/EP2365966A4/fr
Priority to PCT/KR2008/007364 priority patent/WO2010067913A1/fr
Publication of WO2010067913A1 publication Critical patent/WO2010067913A1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La présente invention concerne un procédé d'élimination du groupe protecteur triphénylméthane. Le procédé de préparation de dérivés d'acide benzoïque biphénylique de la présente invention est économiquement avantageux et particulièrement excellent en termes d'amélioration du processus et est caractérisé en ce que: la sécurité du processus est garantie du fait de l'utilisation d'une résine échangeuse d'ions acide en présence de solvant organique à la place d'utiliser de l'acide hautement corrosif; la réaction prend beaucoup moins de temps que les réactions classiques qui font appel uniquement à du méthanol anhydre et la réaction secondaire est quasi inexistante; et la résine échangeuse d'ions de la présente invention est excellente pour le traitement de masse étant donné que la résine peut être récupérée et recyclée uniquement par filtration après utilisation.
PCT/KR2008/007364 2008-12-12 2008-12-12 Procédé d'élimination du groupe protecteur triphénylméthane WO2010067913A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2011534364A JP5575783B2 (ja) 2008-12-12 2008-12-12 トリフェニルメタン保護基の除去方法
EP08878772A EP2365966A4 (fr) 2008-12-12 2008-12-12 Procédé d'élimination du groupe protecteur triphénylméthane
PCT/KR2008/007364 WO2010067913A1 (fr) 2008-12-12 2008-12-12 Procédé d'élimination du groupe protecteur triphénylméthane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/KR2008/007364 WO2010067913A1 (fr) 2008-12-12 2008-12-12 Procédé d'élimination du groupe protecteur triphénylméthane

Publications (1)

Publication Number Publication Date
WO2010067913A1 true WO2010067913A1 (fr) 2010-06-17

Family

ID=42242892

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2008/007364 WO2010067913A1 (fr) 2008-12-12 2008-12-12 Procédé d'élimination du groupe protecteur triphénylméthane

Country Status (3)

Country Link
EP (1) EP2365966A4 (fr)
JP (1) JP5575783B2 (fr)
WO (1) WO2010067913A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013021312A1 (fr) 2011-08-05 2013-02-14 Lupin Limited Procédé de préparation d'olmésartan médoxomil
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006097121A1 (fr) * 2005-03-16 2006-09-21 Ulkar Kimya Sanayii Ve Ticaret A.S. Procede de preparation de composes biphenyltetrazole
SI22127A (sl) * 2005-10-07 2007-04-30 Krka, Tovarna Zdravil, D.D., Novo Mesto Postopek za pripravo kandesartan cileksetila
CN101024643A (zh) * 2006-02-20 2007-08-29 上海艾力斯医药科技有限公司 咪唑－5－羧酸类衍生物、制备方法及其应用

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BEHLING, J. ET AL.: "A short and practical synthesis of 1-deoxynojirimycin", SYNTHETIC COMMUNICATIONS, vol. 21, no. 12-13, 1991, pages 1383 - 1386, XP008146812 *
GREENE, T. W. ET AL.: "Protective Groups in Organic Synthesis, 3rd ed.", 1999, JOHN WILEY & SONS, INC., NEW YORK, ISBN: 0-471-16019-9, pages: 583 - 584, XP008146809 *
SETO, H. ET AL.: "A refined method for the removal of the methoxymethyl (MOM) protecting group from carbinols with an acidic ion-exchange resin", SYNTHETIC COMMUNICATIONS, vol. 22, no. 19, 1992, pages 2823 - 2828, XP008146813 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013021312A1 (fr) 2011-08-05 2013-02-14 Lupin Limited Procédé de préparation d'olmésartan médoxomil
US8981110B2 (en) 2011-08-05 2015-03-17 Lupin Limited Process for the preparation of olmesartan medoxomil
CN104262332A (zh) * 2014-09-16 2015-01-07 上海信谊百路达药业有限公司 一种奥美沙坦酯的制备方法

Also Published As

Publication number Publication date
JP5575783B2 (ja) 2014-08-20
JP2012506902A (ja) 2012-03-22
EP2365966A1 (fr) 2011-09-21
EP2365966A4 (fr) 2012-05-09

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