WO2010058400A1 - Formes solides pour la reparation des tissus - Google Patents

Formes solides pour la reparation des tissus Download PDF

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Publication number
WO2010058400A1
WO2010058400A1 PCT/IL2009/001092 IL2009001092W WO2010058400A1 WO 2010058400 A1 WO2010058400 A1 WO 2010058400A1 IL 2009001092 W IL2009001092 W IL 2009001092W WO 2010058400 A1 WO2010058400 A1 WO 2010058400A1
Authority
WO
WIPO (PCT)
Prior art keywords
scaffold
coral
site
cartilage
repair
Prior art date
Application number
PCT/IL2009/001092
Other languages
English (en)
Inventor
Nir Altschuler
Razi Vago
Original Assignee
Cartiheal (2009) Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SI200931960T priority Critical patent/SI2367556T1/sl
Priority to US13/130,272 priority patent/US8808725B2/en
Application filed by Cartiheal (2009) Ltd. filed Critical Cartiheal (2009) Ltd.
Priority to DK09827265.1T priority patent/DK2367556T3/da
Priority to JP2011537009A priority patent/JP5536793B2/ja
Priority to CA2743461A priority patent/CA2743461C/fr
Priority to EP09827265.1A priority patent/EP2367556B1/fr
Priority to AU2009318835A priority patent/AU2009318835B2/en
Priority to ES09827265T priority patent/ES2712891T3/es
Priority to PL09827265T priority patent/PL2367556T3/pl
Publication of WO2010058400A1 publication Critical patent/WO2010058400A1/fr
Priority to IL212963A priority patent/IL212963A/en
Priority to US14/321,491 priority patent/US20150056262A1/en
Priority to US14/978,510 priority patent/US20160175098A1/en
Priority to AU2016200421A priority patent/AU2016200421B2/en
Priority to HRP20190697TT priority patent/HRP20190697T1/hr
Priority to US17/191,522 priority patent/US20220023050A1/en

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    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
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    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
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    • A61F2002/30878Special external or bone-contacting surface, e.g. coating for improving bone ingrowth applied in original prostheses, e.g. holes or grooves with non-sharp protrusions, for instance contacting the bone for anchoring, e.g. keels, pegs, pins, posts, shanks, stems, struts
    • A61F2002/30891Plurality of protrusions
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    • A61F2/4603Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof
    • A61F2002/4625Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use
    • A61F2002/4627Special tools or methods for implanting or extracting artificial joints, accessories, bone grafts or substitutes, or particular adaptations therefor for insertion or extraction of endoprosthetic joints or of accessories thereof with relative movement between parts of the instrument during use with linear motion along or rotating motion about the instrument axis or the implantation direction, e.g. telescopic, along a guiding rod, screwing inside the instrument
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2230/0067Three-dimensional shapes conical
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
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    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0063Three-dimensional shapes
    • A61F2230/0093Umbrella-shaped, e.g. mushroom-shaped
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    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00341Coral, e.g. aragonite, porite
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404Biocides, antimicrobial agents, antiseptic agents
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/606Coatings
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    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/60Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
    • A61L2300/64Animal cells
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    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/06Materials or treatment for tissue regeneration for cartilage reconstruction, e.g. meniscus

Abstract

L'invention concerne des structures supports à base de corail pour la réparation du cartilage, et des instruments permettant l’insertion et l’utilisation desdites structures supports dans un site de réparation du cartilage.
PCT/IL2009/001092 2008-11-20 2009-11-19 Formes solides pour la reparation des tissus WO2010058400A1 (fr)

Priority Applications (15)

Application Number Priority Date Filing Date Title
PL09827265T PL2367556T3 (pl) 2008-11-20 2009-11-19 Postacie stałe do naprawy tkanek
ES09827265T ES2712891T3 (es) 2008-11-20 2009-11-19 Formas sólidas para reparación de tejidos
DK09827265.1T DK2367556T3 (da) 2008-11-20 2009-11-19 Faste former til reparation af væv
US13/130,272 US8808725B2 (en) 2008-11-20 2009-11-19 Solid forms for tissue repair
CA2743461A CA2743461C (fr) 2008-11-20 2009-11-19 Structure de corail permettant la reparation cartilagineuse ou osteochondrale
EP09827265.1A EP2367556B1 (fr) 2008-11-20 2009-11-19 Formes solides pour la reparation des tissus
AU2009318835A AU2009318835B2 (en) 2008-11-20 2009-11-19 Solid forms for tissue repair
SI200931960T SI2367556T1 (sl) 2008-11-20 2009-11-19 Trdne oblike za obnovo tkiva
JP2011537009A JP5536793B2 (ja) 2008-11-20 2009-11-19 組織修復用固体鋳型
IL212963A IL212963A (en) 2008-11-20 2011-05-17 Solid forms for tissue reconstruction
US14/321,491 US20150056262A1 (en) 2008-11-20 2014-07-01 Solid forms for tissue repair
US14/978,510 US20160175098A1 (en) 2008-11-20 2015-12-22 Solid Forms for Tissue Repair
AU2016200421A AU2016200421B2 (en) 2008-11-20 2016-01-25 Solid forms for tissue repair
HRP20190697TT HRP20190697T1 (hr) 2008-11-20 2019-04-15 Čvrsta konstrukcija za obnovu tkiva
US17/191,522 US20220023050A1 (en) 2008-11-20 2021-03-03 Solid forms for tissue repair

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11650308P 2008-11-20 2008-11-20
US61/116,503 2008-11-20

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US13/130,272 A-371-Of-International US8808725B2 (en) 2008-11-20 2009-11-19 Solid forms for tissue repair
US14/321,491 Continuation US20150056262A1 (en) 2008-11-20 2014-07-01 Solid forms for tissue repair

Publications (1)

Publication Number Publication Date
WO2010058400A1 true WO2010058400A1 (fr) 2010-05-27

Family

ID=42197881

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IL2009/001092 WO2010058400A1 (fr) 2008-11-20 2009-11-19 Formes solides pour la reparation des tissus

Country Status (14)

Country Link
US (4) US8808725B2 (fr)
EP (1) EP2367556B1 (fr)
JP (1) JP5536793B2 (fr)
AU (2) AU2009318835B2 (fr)
CA (1) CA2743461C (fr)
DK (1) DK2367556T3 (fr)
ES (1) ES2712891T3 (fr)
HR (1) HRP20190697T1 (fr)
HU (1) HUE043110T2 (fr)
PL (1) PL2367556T3 (fr)
PT (1) PT2367556T (fr)
SI (1) SI2367556T1 (fr)
TR (1) TR201901133T4 (fr)
WO (1) WO2010058400A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013150537A1 (fr) 2012-04-05 2013-10-10 Cartiheal (2009) Ltd Implants solides multiphasiques pour une réparation de tissu
WO2013171736A1 (fr) 2012-05-17 2013-11-21 Cartiheal(2009) Ltd Biomatrices hydrogels et leurs procédés d'utilisation
WO2014072982A2 (fr) 2012-11-12 2014-05-15 Cartiheal (2009) Ltd. Outils et systèmes pour implantation de greffe et forme solide
WO2014125477A1 (fr) 2013-02-13 2014-08-21 Cartiheal (2009) Ltd Substrats solides pour limiter ou empêcher l'adhérence et la vascularisation de cellules et de tissus
CN106110394A (zh) * 2016-06-27 2016-11-16 梅庆波 一种纳米骨修复材料的制备方法
EP3461462A1 (fr) 2015-05-06 2019-04-03 Cartiheal (2009) Ltd Substrats solides optimisés
WO2019135216A1 (fr) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Outil d'implantation et protocole pour substrats solides optimisés favorisant la croissance cellulaire et tissulaire
WO2020053867A1 (fr) 2018-09-16 2020-03-19 Cartiheal (2009) Ltd. Systèmes de cage optimisés favorisant la réparation et la soudure osseuses

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2721876T3 (es) 2009-06-15 2019-08-06 Cartiheal 2009 Ltd Formas sólidas para reparación tisular
US9498334B2 (en) * 2012-03-27 2016-11-22 DePuy Synthes Products, Inc. Glenoid defect-filling component
AU2013299505B2 (en) * 2012-08-10 2016-12-22 Spinalcyte, Llc Generation of cartilage ex vivo from fibroblasts
US10492921B2 (en) 2015-04-29 2019-12-03 Institute for Musculoskeletal Science and Education, Ltd. Implant with arched bone contacting elements
WO2016176496A1 (fr) 2015-04-29 2016-11-03 Institute for Musculoskeletal Science and Education, Ltd. Implants spiralés, systèmes et procédés d'utilisation de ces derniers
US10449051B2 (en) 2015-04-29 2019-10-22 Institute for Musculoskeletal Science and Education, Ltd. Implant with curved bone contacting elements
US10709570B2 (en) 2015-04-29 2020-07-14 Institute for Musculoskeletal Science and Education, Ltd. Implant with a diagonal insertion axis
JP7143079B2 (ja) * 2015-05-06 2022-09-28 カルティヒール(2009)リミティド 最適化された固体基材、それとともに使用するためのツールならびに細胞及び組織の成長を促進するためのその使用
WO2017077539A1 (fr) 2015-11-03 2017-05-11 Ariel-University Research And Development Company Ltd. Compositions destinées à la régénération et à la réparation de tissu nerveux
US10478312B2 (en) 2016-10-25 2019-11-19 Institute for Musculoskeletal Science and Education, Ltd. Implant with protected fusion zones
US10512549B2 (en) 2017-03-13 2019-12-24 Institute for Musculoskeletal Science and Education, Ltd. Implant with structural members arranged around a ring
US10357377B2 (en) 2017-03-13 2019-07-23 Institute for Musculoskeletal Science and Education, Ltd. Implant with bone contacting elements having helical and undulating planar geometries
US10213317B2 (en) 2017-03-13 2019-02-26 Institute for Musculoskeletal Science and Education Implant with supported helical members
US10667924B2 (en) 2017-03-13 2020-06-02 Institute for Musculoskeletal Science and Education, Ltd. Corpectomy implant
US10744001B2 (en) 2017-11-21 2020-08-18 Institute for Musculoskeletal Science and Education, Ltd. Implant with improved bone contact
US10940015B2 (en) 2017-11-21 2021-03-09 Institute for Musculoskeletal Science and Education, Ltd. Implant with improved flow characteristics
US10695192B2 (en) 2018-01-31 2020-06-30 Institute for Musculoskeletal Science and Education, Ltd. Implant with internal support members
EP4070824A1 (fr) * 2021-04-09 2022-10-12 Regen i Göteborg AB Échafaudages marins pour la génération de tissus humains

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002200A1 (fr) * 1997-07-07 1999-01-21 Australian Institute Of Marine Science Produits ou structures formes pour applications medicales
US20030236573A1 (en) * 2002-06-13 2003-12-25 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being
US20080249632A1 (en) * 2007-02-26 2008-10-09 Biomet Sports Medicine, Inc. Stable cartilage defect repair plug

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2679250B1 (fr) * 1991-07-19 1995-07-13 Inoteb Utilisation de carbonate de calcium poreux comme materiau support de culture in vitro de cellules eucaryotes.
FR2706768B1 (fr) * 1993-05-13 1995-12-01 Inoteb
GB9704749D0 (en) * 1997-03-07 1997-04-23 Univ London Tissue Implant
JP3686335B2 (ja) * 1998-07-13 2005-08-24 ユニヴァースティ オブ サザーン カリフォルニア 骨および軟骨成長と修復を促進する方法
US6626945B2 (en) * 2000-03-14 2003-09-30 Chondrosite, Llc Cartilage repair plug
US6632246B1 (en) * 2000-03-14 2003-10-14 Chondrosite, Llc Cartilage repair plug
US6995013B2 (en) 2002-07-08 2006-02-07 Biomed Solutions, Llc Cell-scaffold composition containing five layers
US20020183858A1 (en) * 2001-06-05 2002-12-05 Contiliano Joseph H. Attachment of absorbable tissue scaffolds to scaffold fixation devices
US7819888B2 (en) * 2001-10-23 2010-10-26 Innovasive Devices, Inc. Method and apparatus for harvesting and implanting bone plugs
DE60230907D1 (de) * 2001-10-25 2009-03-05 Univ Connecticut Fibroinzusammensetzungen und verfahren zu deren herstellung
US7901457B2 (en) * 2003-05-16 2011-03-08 Musculoskeletal Transplant Foundation Cartilage allograft plug
US7666230B2 (en) * 2003-12-08 2010-02-23 Depuy Products, Inc. Implant device for cartilage regeneration in load bearing articulation regions
US20070185585A1 (en) * 2004-03-09 2007-08-09 Brat Bracy Implant Scaffold Combined With Autologous Tissue, Allogenic Tissue, Cultured Tissue, or combinations Thereof
US20080274185A1 (en) * 2004-06-30 2008-11-06 Jeremy Mao Shape and Dimension Maintenance of Soft Tissue Grafts by Stem Cells
US7427293B2 (en) * 2006-03-28 2008-09-23 Sdgi Holdings, Inc. Osteochondral plug graft, kit and method
US8449622B2 (en) 2006-09-11 2013-05-28 Warsaw Orthopedic, Inc. Multi-phase osteochondral implantable device
US20080281431A1 (en) * 2007-05-10 2008-11-13 Biomet Manufacturing Corp. Resorbable bone graft materials
US9744043B2 (en) * 2007-07-16 2017-08-29 Lifenet Health Crafting of cartilage

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999002200A1 (fr) * 1997-07-07 1999-01-21 Australian Institute Of Marine Science Produits ou structures formes pour applications medicales
US20030236573A1 (en) * 2002-06-13 2003-12-25 Evans Douglas G. Devices and methods for treating defects in the tissue of a living being
US20080249632A1 (en) * 2007-02-26 2008-10-09 Biomet Sports Medicine, Inc. Stable cartilage defect repair plug

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013150537A1 (fr) 2012-04-05 2013-10-10 Cartiheal (2009) Ltd Implants solides multiphasiques pour une réparation de tissu
WO2013171736A1 (fr) 2012-05-17 2013-11-21 Cartiheal(2009) Ltd Biomatrices hydrogels et leurs procédés d'utilisation
US10342897B2 (en) 2012-05-17 2019-07-09 Cartiheal (2009) Ltd Biomatrix hydrogels and methods of use thereof
WO2014072982A2 (fr) 2012-11-12 2014-05-15 Cartiheal (2009) Ltd. Outils et systèmes pour implantation de greffe et forme solide
CN105228661A (zh) * 2013-02-13 2016-01-06 卡尔蒂希尔(2009)公司 用于减轻或预防细胞和组织粘附和血管形成的固体基质
KR20150135260A (ko) 2013-02-13 2015-12-02 카티힐 (2009) 엘티디. 세포 및 조직 성장을 촉진하기 위한 고체 기질
US10806823B2 (en) 2013-02-13 2020-10-20 Cartiheal (2009) Ltd. Solid substrates for promoting cell and tissue growth
CN105228662A (zh) * 2013-02-13 2016-01-06 卡尔蒂希尔(2009)公司 用于促进细胞和组织生长的固体基质
WO2014125478A1 (fr) 2013-02-13 2014-08-21 Cartiheal (2009) Ltd Substrats solides pour favoriser la croissance de cellules et de tissus
US9770531B2 (en) 2013-02-13 2017-09-26 Cartiheal (2009) Ltd Solid substrates for mitigating or preventing cell and tissue adhesion and vascularization
WO2014125477A1 (fr) 2013-02-13 2014-08-21 Cartiheal (2009) Ltd Substrats solides pour limiter ou empêcher l'adhérence et la vascularisation de cellules et de tissus
US11878090B2 (en) 2013-02-13 2024-01-23 Cartiheal (2009) Ltd. Solid substrates for promoting cell and tissue growth
US11116873B2 (en) 2013-02-13 2021-09-14 Cartiheal (2009) Ltd. Solid substrates for promoting cell and tissue growth
CN111514377A (zh) * 2013-02-13 2020-08-11 卡尔蒂希尔(2009)公司 用于促进细胞和组织生长的固体基质
EP3461462A1 (fr) 2015-05-06 2019-04-03 Cartiheal (2009) Ltd Substrats solides optimisés
CN106110394A (zh) * 2016-06-27 2016-11-16 梅庆波 一种纳米骨修复材料的制备方法
WO2019135216A1 (fr) 2018-01-02 2019-07-11 Cartiheal (2009) Ltd. Outil d'implantation et protocole pour substrats solides optimisés favorisant la croissance cellulaire et tissulaire
WO2020053867A1 (fr) 2018-09-16 2020-03-19 Cartiheal (2009) Ltd. Systèmes de cage optimisés favorisant la réparation et la soudure osseuses

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PT2367556T (pt) 2019-03-25
EP2367556A1 (fr) 2011-09-28
SI2367556T1 (sl) 2019-09-30
ES2712891T3 (es) 2019-05-16
US20150056262A1 (en) 2015-02-26
AU2016200421A1 (en) 2016-02-11
AU2016200421B2 (en) 2017-10-26
TR201901133T4 (tr) 2019-02-21
HRP20190697T1 (hr) 2019-10-04
CA2743461A1 (fr) 2010-05-27
JP2012509128A (ja) 2012-04-19
AU2009318835B2 (en) 2015-11-19
DK2367556T3 (da) 2019-05-06
JP5536793B2 (ja) 2014-07-02
US20110256228A1 (en) 2011-10-20
EP2367556A4 (fr) 2013-07-17
EP2367556B1 (fr) 2019-01-23
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AU2009318835A1 (en) 2010-05-27
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US8808725B2 (en) 2014-08-19
US20220023050A1 (en) 2022-01-27

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