WO2010044565A3 - 다공성 인산삼칼슘계 과립의 제조방법, 및 이에 의해 제조된 다공성 인산삼칼슘계 과립을 이용한 골이식재의 제조방법 - Google Patents

다공성 인산삼칼슘계 과립의 제조방법, 및 이에 의해 제조된 다공성 인산삼칼슘계 과립을 이용한 골이식재의 제조방법 Download PDF

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Publication number
WO2010044565A3
WO2010044565A3 PCT/KR2009/005737 KR2009005737W WO2010044565A3 WO 2010044565 A3 WO2010044565 A3 WO 2010044565A3 KR 2009005737 W KR2009005737 W KR 2009005737W WO 2010044565 A3 WO2010044565 A3 WO 2010044565A3
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WO
WIPO (PCT)
Prior art keywords
tricalcium phosphate
based granules
bone graft
porous
granules
Prior art date
Application number
PCT/KR2009/005737
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English (en)
French (fr)
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WO2010044565A2 (ko
Inventor
김수홍
Original Assignee
(주)코웰메디
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Publication of WO2010044565A2 publication Critical patent/WO2010044565A2/ko
Publication of WO2010044565A3 publication Critical patent/WO2010044565A3/ko

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58—Materials at least partially resorbable by the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
    • A61L2300/252—Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials For Medical Uses (AREA)
  • Medicinal Preparation (AREA)

Abstract

본 발명은 다공성 인산삼칼슘계 과립의 제조방법, 및 이에 의해 제조된 다공성 인산삼칼슘계 과립을 이용한 골이식재의 제조방법에 관한 것이다. 본 발명에 따른 다공성 인산삼칼슘계 과립의 제조방법은 기공 전구체, 분산매, 유기용매를 사용하지 않고, 칼날을 가진 믹서를 회전시키면서 인산삼칼슘계 슬러리에 인산삼칼슘계 분말을 첨가하는 단계를 반복하여 인산삼칼슘계 과립을 형성시키고, 인산삼칼슘계 과립의 크기를 조절하는 것을 특징으로 한다. 또한, 본 발명에 따른 골이식재의 제조방법은 상기 방법으로 제조된 다공성 인산삼칼슘계 과립을 골형성 단백질 용액에 침지하여 골형성 단백질을 다공성 인산삼칼슘계 과립의 기공에 결합시키고 이를 동결건조시키는 것을 특징으로 한다.
PCT/KR2009/005737 2008-10-13 2009-10-08 다공성 인산삼칼슘계 과립의 제조방법, 및 이에 의해 제조된 다공성 인산삼칼슘계 과립을 이용한 골이식재의 제조방법 WO2010044565A2 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020080100315A KR101109431B1 (ko) 2008-10-13 2008-10-13 다공성 인산삼칼슘계 과립의 제조 방법 및 이를 이용한 기능성 골이식재의 제조방법
KR10-2008-0100315 2008-10-13

Publications (2)

Publication Number Publication Date
WO2010044565A2 WO2010044565A2 (ko) 2010-04-22
WO2010044565A3 true WO2010044565A3 (ko) 2010-07-29

Family

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Application Number Title Priority Date Filing Date
PCT/KR2009/005737 WO2010044565A2 (ko) 2008-10-13 2009-10-08 다공성 인산삼칼슘계 과립의 제조방법, 및 이에 의해 제조된 다공성 인산삼칼슘계 과립을 이용한 골이식재의 제조방법

Country Status (2)

Country Link
KR (1) KR101109431B1 (ko)
WO (1) WO2010044565A2 (ko)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101345794B1 (ko) * 2012-02-17 2013-12-27 한국화학연구원 기공 생성제를 이용한 제3인산칼슘의 제조방법 및 이에 따라 제조되는 제3인산칼슘
KR101364704B1 (ko) * 2012-06-12 2014-02-20 순천향대학교 산학협력단 골 재생을 위한 다공성 하이드로젤 지지체의 제조방법
KR101429857B1 (ko) * 2013-06-19 2014-08-13 순천향대학교 산학협력단 골 지혈작용을 위한 복합이중층 섬유매트의 제조방법
KR101943432B1 (ko) * 2016-12-14 2019-04-18 순천향대학교 산학협력단 서방성 주사용 골 이식재의 제조방법
KR102177267B1 (ko) 2020-04-20 2020-11-11 주식회사 동양케미칼 이노시톨 추출과정에서 발생하는 생성물을 이용한 사료용 삼인산칼슘의 제조방법
CN114591060B (zh) * 2022-04-28 2022-12-23 西北大学 一种石膏—碱式磷酸钙三维互穿材料及其制备方法

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017330A1 (en) * 1996-10-24 1998-04-30 Sdgi Holdings, Inc. Ceramic fusion implants and compositions containing osteoinductive factors
WO2000045867A1 (en) * 1999-02-02 2000-08-10 Dr. H.C. Robert Mathys Stiftung Implant comprising calcium cement and hydrophobic liquid
US20030049328A1 (en) * 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
WO2007011172A1 (en) * 2005-07-20 2007-01-25 Oscotec Inc. Preparation method of porous beta tricalcium phosphate granules

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007068489A2 (en) * 2005-12-14 2007-06-21 Scil Technology Gmbh A moldable biomaterial for bone regeneration

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998017330A1 (en) * 1996-10-24 1998-04-30 Sdgi Holdings, Inc. Ceramic fusion implants and compositions containing osteoinductive factors
WO2000045867A1 (en) * 1999-02-02 2000-08-10 Dr. H.C. Robert Mathys Stiftung Implant comprising calcium cement and hydrophobic liquid
US20030049328A1 (en) * 2001-03-02 2003-03-13 Dalal Paresh S. Porous beta-tricalcium phosphate granules and methods for producing same
WO2007011172A1 (en) * 2005-07-20 2007-01-25 Oscotec Inc. Preparation method of porous beta tricalcium phosphate granules

Also Published As

Publication number Publication date
KR101109431B1 (ko) 2012-02-15
WO2010044565A2 (ko) 2010-04-22
KR20100041237A (ko) 2010-04-22

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