WO2010043317A1 - Dispositif de dosage - Google Patents

Dispositif de dosage Download PDF

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Publication number
WO2010043317A1
WO2010043317A1 PCT/EP2009/007121 EP2009007121W WO2010043317A1 WO 2010043317 A1 WO2010043317 A1 WO 2010043317A1 EP 2009007121 W EP2009007121 W EP 2009007121W WO 2010043317 A1 WO2010043317 A1 WO 2010043317A1
Authority
WO
WIPO (PCT)
Prior art keywords
stop
counter
metering device
reservoir
metering
Prior art date
Application number
PCT/EP2009/007121
Other languages
German (de)
English (en)
Inventor
Thomas Jakob
Frank Skaper
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Publication of WO2010043317A1 publication Critical patent/WO2010043317A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C—APPARATUS FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05C17/00—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces
    • B05C17/005—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes
    • B05C17/015—Hand tools or apparatus using hand held tools, for applying liquids or other fluent materials to, for spreading applied liquids or other fluent materials on, or for partially removing applied liquids or other fluent materials from, surfaces for discharging material from a reservoir or container located in or on the hand tool through an outlet orifice by pressure without using surface contacting members like pads or brushes with pneumatically or hydraulically actuated piston or the like
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01F—MEASURING VOLUME, VOLUME FLOW, MASS FLOW OR LIQUID LEVEL; METERING BY VOLUME
    • G01F11/00—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it
    • G01F11/02—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement
    • G01F11/021—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type
    • G01F11/025—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons
    • G01F11/027—Apparatus requiring external operation adapted at each repeated and identical operation to measure and separate a predetermined volume of fluid or fluent solid material from a supply or container, without regard to weight, and to deliver it with measuring chambers which expand or contract during measurement of the piston type with manually operated pistons of the syringe type

Definitions

  • the invention relates to a metering device for the dosed administration of a flowable preparation together with a flowable carrier medium. Furthermore, the invention relates to a method for filling such a metering device, a substance for use in a method for oral administration of the substance to a person, wherein the substance is administered by means of such a metering device, and a use of such a metering device.
  • dosing devices are either inconvenient to use or suitable for single use only.
  • two-piece dosing syringes with a syringe body and a syringe plunger are also known by public prior use.
  • DE 694 21 928 T2 describes a metering syringe with which predetermined amounts of a liquid pharmaceutical mixture can be dispensed.
  • WO 97/36625 A1 describes an injection device.
  • DE 101 08 440 A describes a syringe and a method for transporting liquids. It is an object of the present invention to develop a metering device of the type mentioned in such a way that it can be used multiple times in particular with simple handling.
  • a metering device which is metered in the manner of a syringe and through which the metered preparation can then be aspirated through the free end of the piston body.
  • the preparation can be mixed in particular with the carrier medium.
  • the metering device according to the invention allows an exact preparation dosage, wherein carrier medium can be added at the same time in a simple manner, which can take an unpleasant taste, for example, the preparation.
  • the metering path on the piston body can be marked in particular with a scale. The Hubbegrenzungs liked facilitates the dosage, so the specification of an amount of administered flowable preparation.
  • a Hubbegrenzungs leveraged according to claim 2 allows the specification of different Dosiermengen with one and the same metering device.
  • the dosing device can then be adapted to the preparation to be administered, to the prescribed therapy and also to the needs and requirements of the respective patient.
  • a stroke limiting device allows safe metering and can be realized inexpensively.
  • a metering device according to claim 4 can manage with a single counter-impact body.
  • a counter-stop body according to claim 5 can be easily converted between different stop positions and is still captive.
  • Passage openings according to claims 6 and 7 can specify reproducible stop positions.
  • a ring according to claim 8 can facilitate the construction of a captive secured to the reservoir counter stop body.
  • a ring design according to claim 9 allows disassembly of the metering device, so a separation of the piston body of the reservoir, without requiring that the ring must be completely removed. This makes it possible to clean the dosing device without having to readjust a preset dosing position after the cleaning process. Since the ring does not have to be removed, the dosing position can also be maintained during cleaning.
  • a ring section design according to claim 10 allows a backup of the counter-stopper body on the reservoir by a conditioning of the ring section on the reservoir under bias. Even with such a ring-section design of the counter-stop body can be designed so that it can be displaced between a stop position and a disassembly position, without requiring the counter-stop body to be completely removed from the reservoir. The ring cut can almost completely surround the reservoir so that it represents a slotted ring.
  • An embodiment of the storage container according to claim 1 1 allows a cost-effective implementation of a switchable between a stop position and a disassembly counter-stop body.
  • An embodiment of the counter-stop body according to claim 12 ensures a secure connection of the counter stop body on the storage container.
  • a latching tongue design according to claim 13 allows a changeover of the counter stop body between different metering positions.
  • a paired design of the latching tongues and / or the latching receptacles according to claims 15 and 16 ensures a secure connection of the counter stop body to the storage container in the respective metering position.
  • the respective metering position can be predetermined, for example, by rotating the piston body.
  • a counter stop body according to claim 18 may optionally cooperate with one of the piston body stops or not.
  • a design according to claim 19 ensures a safe transfer of the counter-stop body in the stop position. This latching connection can be made detachable for changing the dosage or for cleaning.
  • a solid state joint according to claim 20 leads to a captive counter stop body.
  • a passage opening according to claim 21 ensures a secure positioning of the counter stop body in the stop position.
  • a plurality of counter stop bodies according to claim 22 can be used to specify different metering positions.
  • An arrangement of the counter stop body according to claim 23 allows an inexpensive production of the metering device.
  • a Hubbegrenzungs worn according to claim 24 may be executed with container-resistant sleeve and piston-fixed stop or grid elements or vice versa with piston-resistant sleeve and container-fixed stop or Rastele- elements.
  • the respective metering position can be accomplished by rotating the sleeve relative to the stop or latching elements in the circumferential direction about a longitudinal axis of the metering device.
  • Locking recesses according to claim 25 represent an alternative to a stop design.
  • a sleeve according to claim 26 leads to a compact design of the metering device.
  • a locking of the sleeve according to claim 27 ensures a position assurance of this.
  • FIG. 2 is a perspective view of an embodiment of the metering device according to the invention with a stroke limiting device in a representation similar to FIG. 1 with respect to the representation of internal components;
  • FIG. 2 is a perspective view of an embodiment of the metering device according to the invention with a stroke limiting device in a representation similar to FIG. 1 with respect to the representation of internal components;
  • FIG. 3 is a section along the line III-I1I in Fig. 2, 4 shows a perspective view of a further embodiment of the metering device according to the invention with a further embodiment of a stroke limiting device;
  • FIG. 5 is an illustration similar to FIG. 4 of the metering device of FIG. 4 with a counter stop body of the stroke limiting device in a stop position folded over a solid-body joint;
  • FIG. 6 shows a longitudinal section through the metering device according to FIG. 4 in the position of the counter stop body according to FIG. 5;
  • FIG. 7 shows, in a representation similar to FIG. 6, the metering device according to FIG. 4 in a position in which a stop on a piston body of the metering device interacts with the counter-stopper body in the position according to FIGS. 5 and 6;
  • FIG. 8 shows in perspective the piston body of the embodiment according to FIG. 4;
  • FIGS 9 and 10 in perspective two views of another embodiment of a metering device according to the invention with a further embodiment of a Hubbegrenzungs beautifully.
  • Fig. 1 1 is a longitudinal section through the metering device according to Fig. 9;
  • Fig. 12 in a similar to Fig. 1 1 representation of the metering device in a position in which a stop on the piston body cooperates with a convertible counter stop body;
  • FIG. 13 is a perspective view of another embodiment of a metering device according to the invention with a further embodiment of a stroke limiting device, wherein a counter stop body of this is shown in a delivery position latched to a storage container of the metering device;
  • FIG. 14 shows a longitudinal section through the metering device in the position according to FIG. 13;
  • FIG. 15 shows, in a representation similar to FIG. 13, the metering device according to FIG. 13 with the counter-stopper body released;
  • FIG. 16 shows a longitudinal section through the metering device in the position according to FIG. 15;
  • FIG. 17 shows, in a representation similar to FIG. 13, the metering device according to FIG. 13 with the counter stop body in a metering position;
  • FIG. 18 shows a longitudinal section through the metering device in the position according to FIG. 17;
  • FIG. 19 shows, in a representation similar to FIG. 18, the metering device in a position in which a stop on the piston body interacts with the counter stop body;
  • FIG. 20 shows, in a representation similar to FIG. 19, the counterblow body in a disassembled position raised compared to the dosing position;
  • FIG. 22 Longitudinal section (FIG. 22) showing the metering device according to FIG. 13 during disassembly;
  • FIGS. 23 and 24 are perspective views of a further embodiment of a metering device with a further embodiment of a stroke limiting device
  • FIG. 25 shows in perspective a storage container of the metering device according to FIG. 23;
  • FIGS. 26 and 27 in perspective and enlarges a counter stop body of the metering device according to FIG. 23;
  • FIGS. 28 and 29 in perspective view a piston body of the metering device according to FIG. 23 with a one-way valve;
  • FIGS. 30 and 31 for explanation with reference to the metering device according to
  • FIG. 1 shows instantaneous positions of the dosing device during the aspiration of a flowable preparation to be dosed.
  • Fig. 32 for explanation with reference to the metering device according to Fig. 1 is an instantaneous position of the metering device when dispensing a preparation together with a flowable carrier medium.
  • a dosing device basic structure will be explained with reference to a dosing device not according to the invention, which also has the embodiments of the dosing devices according to the invention described hereinafter with reference to FIG.
  • the metering device 1 is used for metered administration of a flowable preparation 2, which is provided in a preparation storage container 3 shown in FIGS. 30 and 31. With the aid of the dosing device 1, the preparation 2 is administered together with a flowable carrier medium 4, which is provided in a carrier medium storage container 5 shown in FIG. 5.
  • the metering device 1 has a hollow cylindrical body 6 made of a transparent plastic material, which has a scale 7.
  • the cylindrical body 6 serves as a storage container for the preparation 2.
  • the cylinder body 6 At its lower end in FIGS. 1 and 3 to 5, the cylinder body 6 has an access opening 8 in which a sieve with a small mesh width is arranged. Via the access opening 8, the interior of the cylinder body 6 communicates with the surroundings.
  • a piston body 9 is arranged in the cylinder body 6, a piston body 9 is arranged.
  • the piston body 9 is also made of plastic.
  • At its the access opening 8 in the cylinder body 6 end facing the piston body 9 has a Um- Fangswulst 10, which seals the Kolbenkö ⁇ er 9 against an inner wall of the Zy Hn der stressess 6.
  • the piston body 9 is displaceable between a starting position shown in FIGS. 1 and 30 and a metering position shown in FIGS. 31 and 32. In the starting position of the Kolbenkö ⁇ er 9 is completely inserted into the Zylinderkö ⁇ er 6. In the dosing position, the piston body 9 is pulled out of the cylinder body 6 up to a distance W corresponding to the desired dosing quantity of the preparation 2 (see FIG. 31).
  • the piston body 9 has a substantially hollow cylindrical construction and releases a fluid connection between a passage opening 1 1, which is arranged between the cylinder body 6 and an interior 12 of the piston body 9, and an intake opening 13 which protrudes at one protruding from the cylinder body 6 End of Kolbenkö ⁇ ers 9 is arranged accessible. This free end is designed as a mouthpiece 14, which cuts off between the suction opening 13 and a handle
  • the one-way valve 16 releases a fluid path from the cylinder body 6 into the interior 12 of the piston body 9 and locks in the opposite direction, ie from the interior 12 of the piston body 9 toward the cylinder body 6, the fluid path.
  • the metering device 22 has a stroke limiting device 23 for limiting a stroke of the piston body 9 between the starting position shown in FIG. 2 and a plurality of metering positions which correspond to different metered quantities of the flowable preparation 2 to be metered.
  • a total of five metering positions can be set, which differ in a stroke distance of the piston body 9 in the reservoir 6 between the starting position and the respective metering position.
  • two metering positions, three metering positions, four metering positions or more than five metering positions can also be used.
  • the Hubbegrenzungs beautiful 23 has a stop sleeve 24 which is arranged in a circumferential space between the piston body 9 and the cylinder body 6, so the reservoir.
  • the stop sleeve 24 Distributed in the circumferential direction about a longitudinal axis of the metering device 22, the stop sleeve 24 has five stop elements 25 to 29, which are numbered in the clockwise direction in FIG. Each of the stop elements 25 to 29 has a circumferential extent of 60 °. Between the stop element 25 and the stop element 29 remains in the stop sleeve 24 in the circumferential direction about the longitudinal axis of the metering device 22, a sleeve breakthrough 30 free.
  • the stop elements 25 to 29 differ in their longitudinal extent, starting from a cylindrical body 6 end face protruding circumferential collar 31 of the stop sleeve 24 to their respective free end.
  • the stop element 25 Towards the valve end of the piston body 9, which carries the Einwege- valve, the stop element 25 has the smallest longitudinal extent.
  • the stop elements 26 to 29 each have a stepped longitudinal extension, so that the stop element 29 has the greatest longitudinal extent on the valve end of the piston body 9.
  • a stopper body 33 of the piston body 9 cooperates, which is formed as formed on the outer circumferential wall of the piston body 9 circumferential nip.
  • the piston body 9 On its outer jacket wall, the piston body 9 has a total of six longitudinally ribs 34 which are sawtooth-shaped in cross-section and which are arranged distributed in the circumferential direction around the longitudinal axis of the metering device 22 in the same direction. Five of these longitudinal ribs 34 engage in this complementarily shaped longitudinal grooves 35 in the inner shell walls of the stop elements 25 to 29 of the stop sleeve 24 a. The sixth of the longitudinal ribs 34 is exposed in the region of the sleeve breakthrough 30.
  • the piston body 9 in the stop sleeve 24 in the circumferential direction about the longitudinal axis of the metering device 22 is possible.
  • a first of these six positions corresponds to the assembly position, in which the circumferential knob 33 lies at the circumferential height of the sleeve aperture 30.
  • the other circumferential positions correspond to the five metering positions of the circumferential knob 33 assigned to the stop elements 25 to 29 for one of the five stop elements 25 to 29, respectively.
  • the stop sleeve 24 is rotatably connected to the cylinder body 6.
  • a securing lug 36 is integrally formed on the stop sleeve 24, which is inserted into a complementary longitudinal groove 37 formed in the cylinder body 6.
  • the longitudinal groove 37 therefore serves as a rotation lock for securing a Relatiwerpitung the stop sleeve 24 to the piston body 9 and thus to the stopper body 33rd
  • latching elements arranged correspondingly in the circumferential direction of the stop sleeve 24 may be provided which cooperate with a latching element, for example a latching recess, integrally formed on the piston body 9 at a circumferential position.
  • the stroke limiting device 23 described above in connection with FIGS. 2 and 3 can also be formed with the stop elements 25 to 29 and the stop body 33 or the corresponding catch bodies in a kinematic reverse variant.
  • the stop sleeve is designed piston-proof and the stopper body is fixed to the cylinder body.
  • FIGS. 4 to 8 A further embodiment according to the invention of a metering device 38 will be explained below with reference to FIGS. 4 to 8. Components and functions consistent with those described above with reference to Figs. 1 to 3 and Figs. 30 to 32 have already been explained, bear the same reference numerals and will not be discussed again in detail.
  • a Hubbegrenzungs worn 39 has in the embodiment of FIGS. 4 to 8 a total of four stopper body, which are formed as equally distributed to the piston body 9 in the circumferential direction and axially offset from each other arranged circumferential knobs. Three of these four stop bodies, namely the stop bodies 40, 41 and 42 are visible in FIG. 8. The fourth stop body is hidden in the illustration of FIG. 8 by the piston body 9.
  • the piston body 9 is secured against rotation in the cylinder body 6 of the metering device 38 is mounted.
  • the four stop bodies cooperate with a container-fixed counter-stop body 43 for the metering position adjustment of the metering device 38.
  • the metering device 38 has four of these counter stop body 43, which are arranged distributed in the circumferential direction in the region of a circumferential collar 44 of the cylinder body 6 and connected via a respective solid joint 45 integral with the cylinder body 6, ie with the reservoir.
  • Each of these four counter stop body 43 is switchable between a neutral position shown in FIG. 4 and a stop position.
  • Each of the counter stop bodies 43 is assigned to one of the four stop bodies (see stop bodies 40 to 42) in the circumferential direction.
  • the counter-abutment bodies 43 have in the region of their outer circumference around the longitudinal axis of the metering device 38 a circumferential extension which corresponds to a typical finger width of a user.
  • Fig. 5 shows the metering device 38 with one of the four stopper body 40, namely the counter stop body 43 shown in FIG. 5 above in the stop position.
  • a stop section 46 of the counter stop body 43 passes through a passage opening 47 in the cylinder body 6 assigned to it.
  • the counter stop body 43 is secured to the cylinder body 6 in a latching manner.
  • FIGS. 6 and 7 illustrates this effectiveness of the counter-stop body 43 in cooperation with the stopper body 40.
  • a longitudinal rib 48 which is formed on the outside of the piston body 9 in the region of the valve end.
  • the longitudinal rib 48 is in a longitudinally complementary thereto formed in the inner wall of the cylinder body. 6
  • the Hubbegrenzungs pain 39 is formed exclusively by integrally formed on the two bodies 6 and 9 components.
  • FIGS. 9 to 12 A further embodiment of a metering device 49 according to the invention will be explained below with reference to FIGS. 9 to 12. Components and functions consistent with those described above with reference to Figs. 1 to 8 and Figs. 30 to 32 have already been explained, bear the same reference numerals and will not be discussed again in detail.
  • the piston body 9 of the metering device 49 has as a piston-fixed stop a stroke limiting device 50 a stop collar 51 which is designed as integrally formed on the outside of the piston body 9 circumferential collar.
  • a counter-stop body 52 of the Hubbegrenzungs till 50 is a on the cylinder body 6, ie the reservoir, secured and to this separate component.
  • the counter-abutment body 52 is subdivided into an outer actuating section 53, a latching section 54 integrally formed thereon and a resilient counter-abutment section 55, which is in turn molded thereto.
  • the counter-abutment body 52 is made of an elastic material. The counter stop body 52 is biased via the elastic counter stop section 55 in the latching position shown in FIG. 9.
  • the bias of the counter-abutment portion 55 is a result of the geometry and elasticity of the elastic material from which the counter-abutment body 52 is made.
  • the latching section 54 has two detent tongues 56 which are opposite in the circumferential direction about the longitudinal axis of the metering device 49, of which the detent tongue 56 facing the observer is shown in FIGS. 9 to 12.
  • the latching tongues 56 lie in complementary recesses 57. The latter are designed in the side walls of a longitudinal groove 58 in the cylinder body 6 of the metering device 49. In total there are four Pairs of locking receptacles 57 in the longitudinal direction of the cylinder body 6 equally spaced from each other.
  • the locking tongues 56 are arranged in one of these pairs of locking receptacles 57.
  • the counter-abutment portion 55 springs in the radial direction to the longitudinal direction of the metering device 49, until an unloaded initially spaced from the piston body 9 middle region of the counter-stop body 52 to lie on the outer wall of the piston body 9 comes.
  • the locking tongues 56 are displaced so far in the radial direction relative to the locking receptacles 57 initially assigned to them, that they are released from these locking receptacles 57.
  • the counter stop body 52 can then be displaced along the cylinder body 6 (see arrow direction 60 in FIG.
  • the counter stop body 52 cooperates in a different, the respective pair of locking receptacles 57 associated metering position of the piston body 9 relative to the cylinder body 6 with the stop collar 51.
  • a counter stop body 62 of a stroke limiting device 63 is formed in the metering device 61 as a clip detachable from the cylinder body 6.
  • the counter-abutment body 62 has a plug-in portion 64, which represents the actual counter-stop, and which is felt through one of a plurality of passage openings 65 in the cylinder body 6.
  • the embodiment shown in FIGS. 13 to 22 has five such equidistantly arranged through openings 65.
  • Boss-like latching steps 66 are formed on the plug-in section 64 and cooperate in a locking manner with the respective passage opening 65 through which the plug section 64 passes.
  • a ring portion 67 of the counter stop body 62 which encompasses approximately half the circumference of the cylinder body 6.
  • the plug portion 64 is formed in the region of half the circumferential extent of the ring portion 67 to this.
  • the plug portion 64 of the counter stop body 62 is made of an elastic material.
  • the plug portion 64 tapers towards its free end, thus has a tapered shape when inserted to the passage opening 65. Due to the latching step 66, a region of the plug-in section 64 whose extent is greater than the width of the passage openings 65, apart from the passage opening 65a, adjoins Return to that represents an undercut in the inserted position of the male portion 64 of the counter-stop body 62.
  • the counter-abutment region of the plug-in section 64 penetrating the respective through-opening 65 cooperates with the stop collar 51 of the piston body 9 in accordance with what was explained above in connection with the stroke-limiting device 50 of the metering device 49.
  • the passage opening 65 through which the plug-in portion 64 of the counter stop body 62 is inserted therethrough, results in a different metering position of the stroke limiting device 63rd
  • FIG. 15 shows that a passage opening 65a arranged on the left in FIG. 15, that is to say on one suction side of the metering device 61, does not taper conically radially inwardly, as is the case with the other passage openings 65, but is designed with a constant passage width.
  • the passage opening 65a therefore does not interact with the latching steps 66 of the plug-in section 64 or, at best, hardly together, so that the counter-stop body 62, as shown in FIG. 15, can be easily removed starting from the position completely inserted into the passage opening 65a.
  • the state in which the counter-abutment body 62 is inserted into the through-hole 65a therefore represents a delivery state or a delivery position of the metering device 61.
  • 17 to 19 show the metering device 61 in a metering position, in which the counter stop body 62 is inserted into the middle of the five passage openings 65. 19 shows the situation in which the counterpart stop area of the plug portion 64 of the counter-stop member 62 cooperates with the stop collar 51.
  • the four passage openings 65 not assigned to the delivery position have, after their conical taper, a widening circumferential step up to which the latching steps 66 can be moved radially outwards into a disassembled position. This disassembly position is shown in FIGS. 20 to 22.
  • the ring portion 67 is under bias of the outer jacket wall of the cylinder body 6.
  • the annular portion 67 engages over a little more than half the circumference of the cylinder body 6, so that in the connection with the bias of a backup of the counter-stop member 62 in the stop position, shown in Figs. 13 and 14 and in FIGS. 17 to 19 is, results.
  • FIGS. 23 to 29 A further embodiment of a metering device 68 according to the invention will now be explained with reference to FIGS. 23 to 29. Components and functions which correspond to those which have already been explained above with reference to FIGS. 1 to 22 and FIGS. 30 to 32, and in particular to FIGS. 13 to 23, bear the same reference numerals and will not be described again in detail discussed.
  • the structure of the metering device 68 corresponds to that of the metering device 61.
  • a ring portion 69 of the counter stop body 62 is executed in the metering device 68 as the cylinder body 6 completely surrounding ring.
  • the ring portion 69 has an inner shell wall which is divided into two peripheral portions 70, 71 which merge into each other via boundary edges 72.
  • the boundary edges 72 run parallel to the longitudinal axis of the cylinder body 6.
  • the inner circumference of each of the peripheral sections 70, 71 corresponds to the outer circumference of the cylinder body 6, so that the ring section 69 can be locked on the cylinder body 6 between two positions. In each of these two positions, one of the two circumferential sections 70, 71 bears against the cylinder body 6 on the outside, while the other of the peripheral sections 71, 70 is released from the outer wall of the cylinder body 6.
  • the plug-in section 64 is integrally formed on the circumferential section 70 shown in FIG. 27 above.
  • FIG. 23 and 24 show the metering device 68 in the delivery state, in which the plug-in section 64 of the counter stop body 62 is guided through the passage opening 65a (see FIG.
  • the passage opening 65a is in turn so large that the plug-in section 64 can be removed from the cylinder body 6 despite its latching steps 66.
  • the plug portion 64 acts as Counter stop with the stop collar 51 of the piston body 9 together.
  • the counter stop body 62 can be switched to the disassembly position, in which the peripheral portion 71 abuts against the outer wall of the cylinder body 6 and in which the plug portion 64 is lifted from the piston body 9 far enough that the stop collar 51 can be guided past the plug-in section 64 for disassembly of the metering device 68.
  • the counter stop body 62 has two semicircular recesses 75a extending toward each other. These recesses 75a are used for the safe reading of a printed on the cylinder body 6 printing a scale on which, for example, the values "1.25 ml", “2.5 ml", “3.75 ml” and "5.0 ml” printed could be.
  • the recesses 75a are formed so that they can be read in the clipped-in state of the counter-stop body 62 safely and without confusion.
  • the passage openings 65 are formed in a peripheral portion 76, which is designed to be raised in relation to the other cylindrical jacket wall of the cylinder body 6.
  • the circumferential section 76 is therefore arranged at a distance from the outer jacket wall of the piston body 9. This results in a gap between the outer casing wall of the piston body 9 and the peripheral portion 76, within which the plug portion 64 of the counter-impact body 62 can be arranged in the disassembly position.
  • the dosing device 1 is in the starting position shown for example in FIG. 30 with the piston body 9 completely inserted.
  • the dosing device 1 is immersed with the access opening 8 having the end in the preparation storage container 3, as shown in FIG. 30.
  • the piston body 9 is now pulled out of the cylinder body 6 in the manner of a syringe plunger.
  • This extraction takes place in the metering devices 22, 38, 49, 61 and 68 according to the invention to the set via the respective Hubbegrenzungs learned dosing.
  • a storage space 21 below the peripheral bead 10 in the access opening 8 adjacent interior of the cylinder body 6 forms a negative pressure.
  • the preparation dosage is completed by the metering device 1.
  • the metering device 1 can be immersed in the metering position in the carrier medium storage container 5 in the metering position shown in FIG. 31 (compare FIG. Subsequently, the operator takes the mouthpiece 14 in the mouth and sucks on it as on a straw.
  • the preparation 2 from the storage space 21 is sucked into the interior 12 of the piston body 9. Since the storage space 21 is in fluid communication with the carrier medium 4 via the access opening 8, the carrier medium 4 is sucked through the access opening 8 into the storage space 21 and also into the interior 12 of the piston body 9 through the access opening 8.
  • the one-way valve 16 acts in the passage or release direction.
  • the preparation 2 and the carrier medium 4 then mix inside the piston body 9.
  • the operator then sucks in a mixture of the preparation 2 and the carrier medium 4 through the outlet opening 13.
  • this mixture may be a preparation 2 diluted to a greater or lesser extent with the carrier medium 4.
  • an unpleasant taste of the preparation 2 can be covered by a corresponding taste of the support medium 4 in this way.
  • an exact dosage of the preparation 2 is ensured by the metering device 1.
  • the dosing device 1 can be easily rinsed with tap water, for example. The rinsed and dried dosing device 1 can then be stored and reused for a new administration of the preparation 2, as explained above.
  • the various components of the devices according to the invention explained above are made of plastic.
  • Preferred materials for these components are polypropylene (PP), polyethylene (PE), acrylonitrile-butadiene-styrene copolymers (ABS), cycloolene copolymers (COC), styrene polymers and copolymers (PS) and polyoxymethylenes (POM).
  • PP polypropylene
  • PE polyethylene
  • ABS acrylonitrile-butadiene-styrene copolymers
  • COC cycloolene copolymers
  • PS styrene polymers and copolymers
  • POM polyoxymethylenes
  • the cylinder body 6 is preferably made of a transparent or translucent PP, alternatively made of a transparent or translucent ABS, PE or COC.
  • the piston body 9 is preferably made of a naturally colored or colored PE, alternatively of a PP or an ABS.
  • the one-way valve 16 is preferably made of a natural-colored or colored silicone (SIK), alternatively made of a thermoplastic elastomer (TEP).
  • SIK natural-colored or colored silicone
  • TEP thermoplastic elastomer
  • the counter stop body 43, 52, 62 is preferably made of a natural or colored PP, alternatively of a PE, ABS, of a styrene polymer or a styrene copolymer. In a clip embodiment of the counter-stop body 43, 52, 62, this can be made of natural-colored or colored POM, alternatively of ABS, styrene copolymers or P.

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  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Containers And Packaging Bodies Having A Special Means To Remove Contents (AREA)

Abstract

L'invention concerne un dispositif de dosage (49) servant au dosage d'une préparation fluide administrée avec un support fluide. Un réservoir (6), qui communique avec l'environnement par l'intermédiaire d'au moins une ouverture d'entrée (8), sert à recevoir la préparation. Un corps de piston (9) est mobile de manière étanche dans le réservoir (6), entre une position de repos, dans laquelle le corps de piston (9) est entièrement rentré dans le réservoir, et une position de dosage, dans laquelle le corps de piston (9) est sorti du réservoir (6) sur une longueur correspondant à une dose souhaitée de la préparation. Le corps de piston (9) creux libère un composé liquide entre une ouverture de passage (11), située entre le réservoir (6) et l'intérieur (12) du piston (9), et une ouverture d'aspiration (13) disposée à une extrémité (14) libre du corps de piston (9) en saillie hors du réservoir (6). Dans l'ouverture de passage (11) est disposée une valve unidirectionnelle (16) qui libère une voie fluide, du réservoir (6) vers l'intérieur du corps de piston (12), et qui l'obture en sens inverse. Un dispositif de limitation de course (50) sert à limiter la course du corps de piston entre une position de départ et au moins deux positions de dosage qui diffèrent sur la longueur entre la position extérieure et la position de dosage correspondante. Ainsi, le dispositif de dosage de l'invention, très maniable, peut être utilisé plusieurs fois.
PCT/EP2009/007121 2008-10-14 2009-10-05 Dispositif de dosage WO2010043317A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE200810051198 DE102008051198A1 (de) 2008-10-14 2008-10-14 Dosiervorrichtung
DE102008051198.6 2008-10-14

Publications (1)

Publication Number Publication Date
WO2010043317A1 true WO2010043317A1 (fr) 2010-04-22

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PCT/EP2009/007121 WO2010043317A1 (fr) 2008-10-14 2009-10-05 Dispositif de dosage

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WO (1) WO2010043317A1 (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010044141A1 (de) 2010-11-18 2012-05-24 Raumedic Ag Dosiervorrichtung
CN104117215A (zh) * 2014-06-30 2014-10-29 长兴百叶龙演出有限公司 一种道具收纳杆
US20150119810A1 (en) * 2013-10-31 2015-04-30 Raumedic Ag Dosage System
US20190022315A1 (en) * 2015-11-19 2019-01-24 Simcro Limited Applicator
US10639660B2 (en) 2016-05-12 2020-05-05 Joma Kunststofftechnik Gmbh Dispensing device

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DE10108440A1 (de) * 2001-02-22 2002-10-10 Forschungszentrum Juelich Gmbh Spritze zum Transport von Flüssigkeiten sowie Verfahren zum Transport von Flüssigkeiten
US20070262164A1 (en) * 2006-05-01 2007-11-15 Daniel Gelfand Drinking Straw
FR2903887A1 (fr) * 2006-07-21 2008-01-25 Part In Pharm Seringue perfectionnee pour administration orale.

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US1578517A (en) * 1924-12-23 1926-03-30 George N Hein Valve piston and barrel construction for hypodermic syringes
GB9316692D0 (en) * 1993-08-11 1993-09-29 Smithkline Beecham Plc Novel device
US6277101B1 (en) * 1996-04-02 2001-08-21 Disetronic Licensing Ag Injection device

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
DE10108440A1 (de) * 2001-02-22 2002-10-10 Forschungszentrum Juelich Gmbh Spritze zum Transport von Flüssigkeiten sowie Verfahren zum Transport von Flüssigkeiten
US20070262164A1 (en) * 2006-05-01 2007-11-15 Daniel Gelfand Drinking Straw
FR2903887A1 (fr) * 2006-07-21 2008-01-25 Part In Pharm Seringue perfectionnee pour administration orale.

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102010044141A1 (de) 2010-11-18 2012-05-24 Raumedic Ag Dosiervorrichtung
WO2012065921A1 (fr) 2010-11-18 2012-05-24 Raumedic Ag Dispositif de dosage
US20130253464A1 (en) * 2010-11-18 2013-09-26 Raumedic Ag Metering device
US9237987B2 (en) 2010-11-18 2016-01-19 Raumedic Ag Metering device
US20150119810A1 (en) * 2013-10-31 2015-04-30 Raumedic Ag Dosage System
CN104117215A (zh) * 2014-06-30 2014-10-29 长兴百叶龙演出有限公司 一种道具收纳杆
US20190022315A1 (en) * 2015-11-19 2019-01-24 Simcro Limited Applicator
US10639660B2 (en) 2016-05-12 2020-05-05 Joma Kunststofftechnik Gmbh Dispensing device

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