WO2010043317A1

WO2010043317A1 - Dosing device

Info

Publication number: WO2010043317A1
Application number: PCT/EP2009/007121
Authority: WO
Inventors: Thomas Jakob; Frank Skaper
Original assignee: Sandoz Ag
Priority date: 2008-10-14
Filing date: 2009-10-05
Publication date: 2010-04-22
Also published as: DE102008051198A1

Abstract

The invention relates to a dosing device (49) for dosed enrichment of a free-flowing preparation together with a free-flowing carrier medium. A reservoir tank (6) communicating with the environment by means of at least one access opening (8) serves for receiving the preparation. A piston body (9) can be moved in the reservoir tank (6) in a sealed manner between a rest position, in which the piston body (9) is fully inserted in the reservoir tank, and a dosing position, in which the piston body (9) is drawn out of the reservoir tank (6) by a distance corresponding to a desired dosing amount of the preparation. The piston body (9) is hollow and exposes a fluid connection between a pass-through opening (11) between the reservoir tank (6) and an interior (12) of the piston body (9), and an intake opening (13) on a free end (14) of the piston body (9) extending out of the reservoir tank (6). A one-way valve (16) is disposed in the pass-through opening (11), opening a fluid path from the reservoir tank (6) into the interior (12) of the piston body and closing said path in the opposite direction. A stroke-limiting device (50) limits the piston body stroke between the starting position and at least two dosing positions differing in the distance between the outer position and each dosing position. A dosing device that is easy to use and particularly can be used multiple times is the result.

Description

metering

The invention relates to a metering device for the dosed administration of a flowable preparation together with a flowable carrier medium. Furthermore, the invention relates to a method for filling such a metering device, a substance for use in a method for oral administration of the substance to a person, wherein the substance is administered by means of such a metering device, and a use of such a metering device.

A metering device of the type mentioned, for example in the form of a measuring spoon, known by public prior use. Also known by public prior use is a variant of such a metering device in the form of a straw in which a carrier body is bound for a bound thereto, initially solid, but soluble in liquid preparation. Such dosing devices are either inconvenient to use or suitable for single use only. Also known by public prior use are two-piece dosing syringes with a syringe body and a syringe plunger.

From US 1,578,517 a device for mixing a preparation for a dosing syringe is known. DE 694 21 928 T2 describes a metering syringe with which predetermined amounts of a liquid pharmaceutical mixture can be dispensed. WO 97/36625 A1 describes an injection device. DE 101 08 440 A describes a syringe and a method for transporting liquids. It is an object of the present invention to develop a metering device of the type mentioned in such a way that it can be used multiple times in particular with simple handling.

This object is achieved by a metering device with the features specified in claim 1.

According to the invention, it has been recognized that by disposing the one-way valve in the passage opening of the piston body, a metering device can be provided which is metered in the manner of a syringe and through which the metered preparation can then be aspirated through the free end of the piston body. In this case, the preparation can be mixed in particular with the carrier medium. The metering device according to the invention allows an exact preparation dosage, wherein carrier medium can be added at the same time in a simple manner, which can take an unpleasant taste, for example, the preparation. For exact metering, the metering path on the piston body can be marked in particular with a scale. The Hubbegrenzungseinrichtung facilitates the dosage, so the specification of an amount of administered flowable preparation.

A Hubbegrenzungseinrichtung according to claim 2 allows the specification of different Dosiermengen with one and the same metering device. The dosing device can then be adapted to the preparation to be administered, to the prescribed therapy and also to the needs and requirements of the respective patient.

A stroke limiting device according to claim 3 allows safe metering and can be realized inexpensively. A metering device according to claim 4 can manage with a single counter-impact body.

A counter-stop body according to claim 5 can be easily converted between different stop positions and is still captive.

Passage openings according to claims 6 and 7 can specify reproducible stop positions.

A ring according to claim 8 can facilitate the construction of a captive secured to the reservoir counter stop body.

A ring design according to claim 9 allows disassembly of the metering device, so a separation of the piston body of the reservoir, without requiring that the ring must be completely removed. This makes it possible to clean the dosing device without having to readjust a preset dosing position after the cleaning process. Since the ring does not have to be removed, the dosing position can also be maintained during cleaning.

A ring section design according to claim 10 allows a backup of the counter-stopper body on the reservoir by a conditioning of the ring section on the reservoir under bias. Even with such a ring-section design of the counter-stop body can be designed so that it can be displaced between a stop position and a disassembly position, without requiring the counter-stop body to be completely removed from the reservoir. The ring cut can almost completely surround the reservoir so that it represents a slotted ring.

An embodiment of the storage container according to claim 1 1 allows a cost-effective implementation of a switchable between a stop position and a disassembly counter-stop body.

An embodiment of the counter-stop body according to claim 12 ensures a secure connection of the counter stop body on the storage container.

A latching tongue design according to claim 13 allows a changeover of the counter stop body between different metering positions.

In an embodiment according to claim 14 of the counter-stopper body itself provides for this biasing in the locking position biasing force.

A paired design of the latching tongues and / or the latching receptacles according to claims 15 and 16 ensures a secure connection of the counter stop body to the storage container in the respective metering position.

In a design of the stroke limiting device according to claim 17, the respective metering position can be predetermined, for example, by rotating the piston body.

A counter stop body according to claim 18 may optionally cooperate with one of the piston body stops or not. A design according to claim 19 ensures a safe transfer of the counter-stop body in the stop position. This latching connection can be made detachable for changing the dosage or for cleaning.

A solid state joint according to claim 20 leads to a captive counter stop body.

A passage opening according to claim 21 ensures a secure positioning of the counter stop body in the stop position.

A plurality of counter stop bodies according to claim 22 can be used to specify different metering positions.

An arrangement of the counter stop body according to claim 23 allows an inexpensive production of the metering device.

A Hubbegrenzungseinrichtung according to claim 24 may be executed with container-resistant sleeve and piston-fixed stop or grid elements or vice versa with piston-resistant sleeve and container-fixed stop or Rastele- elements. Here, the respective metering position can be accomplished by rotating the sleeve relative to the stop or latching elements in the circumferential direction about a longitudinal axis of the metering device.

Locking recesses according to claim 25 represent an alternative to a stop design.

A sleeve according to claim 26 leads to a compact design of the metering device. A locking of the sleeve according to claim 27 ensures a position assurance of this.

The same applies to a rotation lock according to claim 28, which may be designed in particular as a longitudinal groove in the reservoir.

The advantages of a filling method according to claim 29, a substance according to claim 30 and a use of the metering device according to claim 31 correspond to those which have already been explained above in connection with the metering device.

Embodiments of the invention will be explained in more detail with reference to the drawing. In this show:

1 to illustrate major components of a metering device without Hubbegrenzungseinrichtung invention for limiting a piston body stroke between a starting position and at least two metering positions, wherein not visible internal components are shown in dashed lines;

FIG. 2 is a perspective view of an embodiment of the metering device according to the invention with a stroke limiting device in a representation similar to FIG. 1 with respect to the representation of internal components; FIG.

3 is a section along the line III-I1I in Fig. 2, 4 shows a perspective view of a further embodiment of the metering device according to the invention with a further embodiment of a stroke limiting device;

FIG. 5 is an illustration similar to FIG. 4 of the metering device of FIG. 4 with a counter stop body of the stroke limiting device in a stop position folded over a solid-body joint; FIG.

FIG. 6 shows a longitudinal section through the metering device according to FIG. 4 in the position of the counter stop body according to FIG. 5; FIG.

7 shows, in a representation similar to FIG. 6, the metering device according to FIG. 4 in a position in which a stop on a piston body of the metering device interacts with the counter-stopper body in the position according to FIGS. 5 and 6;

FIG. 8 shows in perspective the piston body of the embodiment according to FIG. 4; FIG.

Figures 9 and 10 in perspective two views of another embodiment of a metering device according to the invention with a further embodiment of a Hubbegrenzungseinrichtung.

Fig. 1 1 is a longitudinal section through the metering device according to Fig. 9;

Fig. 12 in a similar to Fig. 1 1 representation of the metering device in a position in which a stop on the piston body cooperates with a convertible counter stop body;

13 is a perspective view of another embodiment of a metering device according to the invention with a further embodiment of a stroke limiting device, wherein a counter stop body of this is shown in a delivery position latched to a storage container of the metering device;

FIG. 14 shows a longitudinal section through the metering device in the position according to FIG. 13; FIG.

FIG. 15 shows, in a representation similar to FIG. 13, the metering device according to FIG. 13 with the counter-stopper body released; FIG.

FIG. 16 shows a longitudinal section through the metering device in the position according to FIG. 15; FIG.

FIG. 17 shows, in a representation similar to FIG. 13, the metering device according to FIG. 13 with the counter stop body in a metering position; FIG.

FIG. 18 shows a longitudinal section through the metering device in the position according to FIG. 17; FIG.

19 shows, in a representation similar to FIG. 18, the metering device in a position in which a stop on the piston body interacts with the counter stop body; FIG. 20 shows, in a representation similar to FIG. 19, the counterblow body in a disassembled position raised compared to the dosing position; FIG.

21 and 22 snapshots in perspective (Fig. 21) and

Longitudinal section (FIG. 22) showing the metering device according to FIG. 13 during disassembly;

FIGS. 23 and 24 are perspective views of a further embodiment of a metering device with a further embodiment of a stroke limiting device;

FIG. 25 shows in perspective a storage container of the metering device according to FIG. 23; FIG.

FIGS. 26 and 27 in perspective and enlarges a counter stop body of the metering device according to FIG. 23;

FIGS. 28 and 29 in perspective view a piston body of the metering device according to FIG. 23 with a one-way valve;

FIGS. 30 and 31 for explanation with reference to the metering device according to

FIG. 1 shows instantaneous positions of the dosing device during the aspiration of a flowable preparation to be dosed. FIG. and

Fig. 32 for explanation with reference to the metering device according to Fig. 1 is an instantaneous position of the metering device when dispensing a preparation together with a flowable carrier medium. In the following, a dosing device basic structure will be explained with reference to a dosing device not according to the invention, which also has the embodiments of the dosing devices according to the invention described hereinafter with reference to FIG.

This, the basic structure performing dosing device is also shown in the final Fig. 30 to 32, with the help of which at the end of the following description, the operation of the erfmdungs- dosing devices will be explained.

The metering device 1 is used for metered administration of a flowable preparation 2, which is provided in a preparation storage container 3 shown in FIGS. 30 and 31. With the aid of the dosing device 1, the preparation 2 is administered together with a flowable carrier medium 4, which is provided in a carrier medium storage container 5 shown in FIG. 5.

The metering device 1 has a hollow cylindrical body 6 made of a transparent plastic material, which has a scale 7. The cylindrical body 6 serves as a storage container for the preparation 2. At its lower end in FIGS. 1 and 3 to 5, the cylinder body 6 has an access opening 8 in which a sieve with a small mesh width is arranged. Via the access opening 8, the interior of the cylinder body 6 communicates with the surroundings.

In the cylinder body 6, a piston body 9 is arranged. The piston body 9 is also made of plastic. At its the access opening 8 in the cylinder body 6 end facing the piston body 9 has a Um- Fangswulst 10, which seals the Kolbenköφer 9 against an inner wall of the Zy Hn derkörpers 6.

The piston body 9 is displaceable between a starting position shown in FIGS. 1 and 30 and a metering position shown in FIGS. 31 and 32. In the starting position of the Kolbenköφer 9 is completely inserted into the Zylinderköφer 6. In the dosing position, the piston body 9 is pulled out of the cylinder body 6 up to a distance W corresponding to the desired dosing quantity of the preparation 2 (see FIG. 31).

The piston body 9 has a substantially hollow cylindrical construction and releases a fluid connection between a passage opening 1 1, which is arranged between the cylinder body 6 and an interior 12 of the piston body 9, and an intake opening 13 which protrudes at one protruding from the cylinder body 6 End of Kolbenköφers 9 is arranged accessible. This free end is designed as a mouthpiece 14, which cuts off between the suction opening 13 and a handle

15 of the Kolbenköφers 9 is arranged.

In the through hole 1 1 of the Kolbenköφers 9 is a one-way valve

16 arranged. The one-way valve 16 releases a fluid path from the cylinder body 6 into the interior 12 of the piston body 9 and locks in the opposite direction, ie from the interior 12 of the piston body 9 toward the cylinder body 6, the fluid path.

2 and 3, a further embodiment according to the invention of a metering device 22 will be explained below. Components and functions consistent with those described above with reference to Fig. 1 and Fig. 30 to 32 have already been explained, bear the same reference numerals and will not be discussed again in detail.

The metering device 22 has a stroke limiting device 23 for limiting a stroke of the piston body 9 between the starting position shown in FIG. 2 and a plurality of metering positions which correspond to different metered quantities of the flowable preparation 2 to be metered. In the illustrated embodiment, a total of five metering positions can be set, which differ in a stroke distance of the piston body 9 in the reservoir 6 between the starting position and the respective metering position. In alternative embodiments of the stroke limiting device 23, two metering positions, three metering positions, four metering positions or more than five metering positions can also be used.

The Hubbegrenzungseinrichtung 23 has a stop sleeve 24 which is arranged in a circumferential space between the piston body 9 and the cylinder body 6, so the reservoir. Distributed in the circumferential direction about a longitudinal axis of the metering device 22, the stop sleeve 24 has five stop elements 25 to 29, which are numbered in the clockwise direction in FIG. Each of the stop elements 25 to 29 has a circumferential extent of 60 °. Between the stop element 25 and the stop element 29 remains in the stop sleeve 24 in the circumferential direction about the longitudinal axis of the metering device 22, a sleeve breakthrough 30 free.

The stop elements 25 to 29 differ in their longitudinal extent, starting from a cylindrical body 6 end face protruding circumferential collar 31 of the stop sleeve 24 to their respective free end. Towards the valve end of the piston body 9, which carries the Einwege- valve, the stop element 25 has the smallest longitudinal extent. In contrast, the stop elements 26 to 29 each have a stepped longitudinal extension, so that the stop element 29 has the greatest longitudinal extent on the valve end of the piston body 9. With facing away from the circumferential collar 31 end walls 32 of the stop elements 25 to 29, a stopper body 33 of the piston body 9 cooperates, which is formed as formed on the outer circumferential wall of the piston body 9 circumferential nip. When mounting the metering device 22, this circumferential knob 33 is passed through the sleeve breakthrough 30 of the stop sleeve 24.

On its outer jacket wall, the piston body 9 has a total of six longitudinally ribs 34 which are sawtooth-shaped in cross-section and which are arranged distributed in the circumferential direction around the longitudinal axis of the metering device 22 in the same direction. Five of these longitudinal ribs 34 engage in this complementarily shaped longitudinal grooves 35 in the inner shell walls of the stop elements 25 to 29 of the stop sleeve 24 a. The sixth of the longitudinal ribs 34 is exposed in the region of the sleeve breakthrough 30. Due to the sawtooth cross-sectional representation of the longitudinal ribs 34 and the complementary thereto longitudinal grooves 35 is a Klick-Relatiwerstellung the piston body 9 in the stop sleeve 24 in the circumferential direction about the longitudinal axis of the metering device 22 is possible. Overall, six different peripheral relative positions of the piston body 9 can be given to the stop sleeve 24. A first of these six positions corresponds to the assembly position, in which the circumferential knob 33 lies at the circumferential height of the sleeve aperture 30. The other circumferential positions correspond to the five metering positions of the circumferential knob 33 assigned to the stop elements 25 to 29 for one of the five stop elements 25 to 29, respectively. The stop sleeve 24 is rotatably connected to the cylinder body 6. For this purpose, a securing lug 36 is integrally formed on the stop sleeve 24, which is inserted into a complementary longitudinal groove 37 formed in the cylinder body 6. The longitudinal groove 37 therefore serves as a rotation lock for securing a Relatiwerdrehung the stop sleeve 24 to the piston body 9 and thus to the stopper body 33rd

At the initial collar 31 of the stop sleeve 24 are also two Halteele- elements 37 a formed between which the stop sleeve 24 and thus the cylinder body 6 when pulling out of the piston body 9 from the cylinder body 6 can be held for dosing.

Instead of the stop elements 25 to 29 and the stopper body 33, latching elements arranged correspondingly in the circumferential direction of the stop sleeve 24 may be provided which cooperate with a latching element, for example a latching recess, integrally formed on the piston body 9 at a circumferential position.

In principle, the stroke limiting device 23 described above in connection with FIGS. 2 and 3 can also be formed with the stop elements 25 to 29 and the stop body 33 or the corresponding catch bodies in a kinematic reverse variant. In this case, the stop sleeve is designed piston-proof and the stopper body is fixed to the cylinder body.

A further embodiment according to the invention of a metering device 38 will be explained below with reference to FIGS. 4 to 8. Components and functions consistent with those described above with reference to Figs. 1 to 3 and Figs. 30 to 32 have already been explained, bear the same reference numerals and will not be discussed again in detail.

A Hubbegrenzungseinrichtung 39 has in the embodiment of FIGS. 4 to 8 a total of four stopper body, which are formed as equally distributed to the piston body 9 in the circumferential direction and axially offset from each other arranged circumferential knobs. Three of these four stop bodies, namely the stop bodies 40, 41 and 42 are visible in FIG. 8. The fourth stop body is hidden in the illustration of FIG. 8 by the piston body 9.

The piston body 9 is secured against rotation in the cylinder body 6 of the metering device 38 is mounted.

The four stop bodies (see Figures 40 to 42) cooperate with a container-fixed counter-stop body 43 for the metering position adjustment of the metering device 38. Overall, the metering device 38 has four of these counter stop body 43, which are arranged distributed in the circumferential direction in the region of a circumferential collar 44 of the cylinder body 6 and connected via a respective solid joint 45 integral with the cylinder body 6, ie with the reservoir. Each of these four counter stop body 43 is switchable between a neutral position shown in FIG. 4 and a stop position. Each of the counter stop bodies 43 is assigned to one of the four stop bodies (see stop bodies 40 to 42) in the circumferential direction. The counter-abutment bodies 43 have in the region of their outer circumference around the longitudinal axis of the metering device 38 a circumferential extension which corresponds to a typical finger width of a user.

Fig. 5 shows the metering device 38 with one of the four stopper body 40, namely the counter stop body 43 shown in FIG. 5 above in the stop position. In this, a stop section 46 of the counter stop body 43 passes through a passage opening 47 in the cylinder body 6 assigned to it. In the stop position, the counter stop body 43 is secured to the cylinder body 6 in a latching manner.

Depending on which of the four stopper 43 is transferred to the stop position, another of the four stopper body on the piston body 9 (see stop body 40 to 42) is effective. The sequence of FIGS. 6 and 7 illustrates this effectiveness of the counter-stop body 43 in cooperation with the stopper body 40.

To prevent rotation of the piston body 9 in the cylinder body 6 is a longitudinal rib 48, which is formed on the outside of the piston body 9 in the region of the valve end. In the assembled situation of the metering device 38, the longitudinal rib 48 is in a longitudinally complementary thereto formed in the inner wall of the cylinder body. 6

The Hubbegrenzungseinrichtung 39 is formed exclusively by integrally formed on the two bodies 6 and 9 components.

A further embodiment of a metering device 49 according to the invention will be explained below with reference to FIGS. 9 to 12. Components and functions consistent with those described above with reference to Figs. 1 to 8 and Figs. 30 to 32 have already been explained, bear the same reference numerals and will not be discussed again in detail.

The piston body 9 of the metering device 49 has as a piston-fixed stop a stroke limiting device 50 a stop collar 51 which is designed as integrally formed on the outside of the piston body 9 circumferential collar.

As a counter-stop body 52 of the Hubbegrenzungseinrichtung 50 is a on the cylinder body 6, ie the reservoir, secured and to this separate component. The counter-abutment body 52 is subdivided into an outer actuating section 53, a latching section 54 integrally formed thereon and a resilient counter-abutment section 55, which is in turn molded thereto. The counter-abutment body 52 is made of an elastic material. The counter stop body 52 is biased via the elastic counter stop section 55 in the latching position shown in FIG. 9.

The bias of the counter-abutment portion 55 is a result of the geometry and elasticity of the elastic material from which the counter-abutment body 52 is made.

The latching section 54 has two detent tongues 56 which are opposite in the circumferential direction about the longitudinal axis of the metering device 49, of which the detent tongue 56 facing the observer is shown in FIGS. 9 to 12. The latching tongues 56 lie in complementary recesses 57. The latter are designed in the side walls of a longitudinal groove 58 in the cylinder body 6 of the metering device 49. In total there are four Pairs of locking receptacles 57 in the longitudinal direction of the cylinder body 6 equally spaced from each other. The locking tongues 56 are arranged in one of these pairs of locking receptacles 57.

By pressing on the actuating portion 53 in the direction of arrow 59 in FIG. 1 1, the counter-abutment portion 55 springs in the radial direction to the longitudinal direction of the metering device 49, until an unloaded initially spaced from the piston body 9 middle region of the counter-stop body 52 to lie on the outer wall of the piston body 9 comes. In this position, the locking tongues 56 are displaced so far in the radial direction relative to the locking receptacles 57 initially assigned to them, that they are released from these locking receptacles 57. The counter stop body 52 can then be displaced along the cylinder body 6 (see arrow direction 60 in FIG. In this way, it is possible to change between the reception of the latching tongues 56 from a pair of latching receivers 57 initially associated therewith to another pair of latching receivers 57. Accordingly, the counter stop body 52 cooperates in a different, the respective pair of locking receptacles 57 associated metering position of the piston body 9 relative to the cylinder body 6 with the stop collar 51.

As far as the piston body 9 in the execution of the metering device 49 is secured against rotation in the cylinder body 6, instead of the stop collar 51 in a counter stop body 52 corresponding circumferential position a circumferential knob corresponding to the stopper body in the embodiment of FIGS. 2 and 3, so accordingly the circumferential knob 33 may be provided. A further embodiment according to the invention of a metering device 61 will be explained below with reference to FIGS. 13 to 22. Components and functions which correspond to those which have already been explained above with reference to FIGS. 1 to 12 and FIGS. 30 to 32 have the same reference numerals and will not be discussed again in detail.

A counter stop body 62 of a stroke limiting device 63 is formed in the metering device 61 as a clip detachable from the cylinder body 6. The counter-abutment body 62 has a plug-in portion 64, which represents the actual counter-stop, and which is felt through one of a plurality of passage openings 65 in the cylinder body 6. The embodiment shown in FIGS. 13 to 22 has five such equidistantly arranged through openings 65. Boss-like latching steps 66 are formed on the plug-in section 64 and cooperate in a locking manner with the respective passage opening 65 through which the plug section 64 passes. Formed on the plug-in portion 64 is a ring portion 67 of the counter stop body 62, which encompasses approximately half the circumference of the cylinder body 6. The plug portion 64 is formed in the region of half the circumferential extent of the ring portion 67 to this.

The plug portion 64 of the counter stop body 62 is made of an elastic material. The plug portion 64 tapers towards its free end, thus has a tapered shape when inserted to the passage opening 65. Due to the latching step 66, a region of the plug-in section 64 whose extent is greater than the width of the passage openings 65, apart from the passage opening 65a, adjoins Return to that represents an undercut in the inserted position of the male portion 64 of the counter-stop body 62.

The counter-abutment region of the plug-in section 64 penetrating the respective through-opening 65 cooperates with the stop collar 51 of the piston body 9 in accordance with what was explained above in connection with the stroke-limiting device 50 of the metering device 49. Depending on the axial position of the passage opening 65, through which the plug-in portion 64 of the counter stop body 62 is inserted therethrough, results in a different metering position of the stroke limiting device 63rd

For example, FIG. 15 shows that a passage opening 65a arranged on the left in FIG. 15, that is to say on one suction side of the metering device 61, does not taper conically radially inwardly, as is the case with the other passage openings 65, but is designed with a constant passage width. The passage opening 65a therefore does not interact with the latching steps 66 of the plug-in section 64 or, at best, hardly together, so that the counter-stop body 62, as shown in FIG. 15, can be easily removed starting from the position completely inserted into the passage opening 65a. The state in which the counter-abutment body 62 is inserted into the through-hole 65a therefore represents a delivery state or a delivery position of the metering device 61.

17 to 19 show the metering device 61 in a metering position, in which the counter stop body 62 is inserted into the middle of the five passage openings 65. 19 shows the situation in which the counterpart stop area of the plug portion 64 of the counter-stop member 62 cooperates with the stop collar 51.

In the radial direction towards the longitudinal axis of the cylinder body 6, the four passage openings 65 not assigned to the delivery position have, after their conical taper, a widening circumferential step up to which the latching steps 66 can be moved radially outwards into a disassembled position. This disassembly position is shown in FIGS. 20 to 22.

The ring portion 67 is under bias of the outer jacket wall of the cylinder body 6. The annular portion 67 engages over a little more than half the circumference of the cylinder body 6, so that in the connection with the bias of a backup of the counter-stop member 62 in the stop position, shown in Figs. 13 and 14 and in FIGS. 17 to 19 is, results.

In the disassembly position of the plug portion 64 is so far radially lifted from the piston body 9, that the stop collar 51 can be displaced past the plug portion 64. This is shown in the sequence of FIGS. 20 to 22. In the disassembly position of the counter stop body 62, therefore, the piston body 9 can be completely pulled out of the cylinder body 6 for cleaning the metering device 61.

The latching connection of the latching step 66 into the passage openings 65 not used in the delivery state ensures that once set the various metering positions can not be changed by the user. These default settings of the dosing position can be made for example by a doctor or a pharmacist. A further embodiment of a metering device 68 according to the invention will now be explained with reference to FIGS. 23 to 29. Components and functions which correspond to those which have already been explained above with reference to FIGS. 1 to 22 and FIGS. 30 to 32, and in particular to FIGS. 13 to 23, bear the same reference numerals and will not be described again in detail discussed.

From the basic structure forth, the structure of the metering device 68 corresponds to that of the metering device 61. A ring portion 69 of the counter stop body 62 is executed in the metering device 68 as the cylinder body 6 completely surrounding ring. The ring portion 69 has an inner shell wall which is divided into two peripheral portions 70, 71 which merge into each other via boundary edges 72. The boundary edges 72 run parallel to the longitudinal axis of the cylinder body 6. The inner circumference of each of the peripheral sections 70, 71 corresponds to the outer circumference of the cylinder body 6, so that the ring section 69 can be locked on the cylinder body 6 between two positions. In each of these two positions, one of the two circumferential sections 70, 71 bears against the cylinder body 6 on the outside, while the other of the peripheral sections 71, 70 is released from the outer wall of the cylinder body 6.

The plug-in section 64 is integrally formed on the circumferential section 70 shown in FIG. 27 above.

23 and 24 show the metering device 68 in the delivery state, in which the plug-in section 64 of the counter stop body 62 is guided through the passage opening 65a (see FIG. The passage opening 65a is in turn so large that the plug-in section 64 can be removed from the cylinder body 6 despite its latching steps 66. In the metering positions, ie when the counter stop body 62 of the metering device 68 with the plug portion 64 is passed through the remaining four passage openings 65 so that the peripheral portion 70 comes to rest on the outer wall of the cylinder body 6, in turn, the plug portion 64 acts as Counter stop with the stop collar 51 of the piston body 9 together. By an actuating pressure along the plug portion 64 in the direction of arrow 73 of FIG. 24, the counter stop body 62 can be switched to the disassembly position, in which the peripheral portion 71 abuts against the outer wall of the cylinder body 6 and in which the plug portion 64 is lifted from the piston body 9 far enough that the stop collar 51 can be guided past the plug-in section 64 for disassembly of the metering device 68.

When counter-stop body 62 of the metering device 68 of the plug portion 64 has two spaced by a gap 74 locking pins 75. Each of the two locking pins 75 has one of the locking steps 66th

In the region of an actuation corrugation in the region of the peripheral section 70 shown in FIGS. 26 and 27 above, ie where the plug section 64 is formed, the counter stop body 62 has two semicircular recesses 75a extending toward each other. These recesses 75a are used for the safe reading of a printed on the cylinder body 6 printing a scale on which, for example, the values "1.25 ml", "2.5 ml", "3.75 ml" and "5.0 ml" printed could be. The recesses 75a are formed so that they can be read in the clipped-in state of the counter-stop body 62 safely and without confusion. In the metering device 68, the passage openings 65 are formed in a peripheral portion 76, which is designed to be raised in relation to the other cylindrical jacket wall of the cylinder body 6. The circumferential section 76 is therefore arranged at a distance from the outer jacket wall of the piston body 9. This results in a gap between the outer casing wall of the piston body 9 and the peripheral portion 76, within which the plug portion 64 of the counter-impact body 62 can be arranged in the disassembly position.

The use of the above-described variants of the metering devices according to the invention is explained below using the example of the metering device 1 and FIGS. 1 and 30 to 32:

First, the dosing device 1 is in the starting position shown for example in FIG. 30 with the piston body 9 completely inserted. In this initial position, the dosing device 1 is immersed with the access opening 8 having the end in the preparation storage container 3, as shown in FIG. 30. In this submerged position, the piston body 9 is now pulled out of the cylinder body 6 in the manner of a syringe plunger. This extraction takes place in the metering devices 22, 38, 49, 61 and 68 according to the invention to the set via the respective Hubbegrenzungseinrichtung dosing. Here, in a storage space 21 below the peripheral bead 10 in the access opening 8 adjacent interior of the cylinder body 6 forms a negative pressure. In particular, air can not flow from the interior 12 of the piston body 9 into the reservoir 21, since this fluid path is blocked by the one-way valve 16. Due to the resulting negative pressure in the reservoir 21, the preparation 2 is sucked into the reservoir 21. The amount of the absorbed preparation 2 in the reservoir 21 can be over the Read off scaling 7. Such a scaling can also be provided in the metering devices 22, 38, 49, 61 and 68.

As soon as sufficient preparation 2 is present in the storage space 21, the preparation dosage is completed by the metering device 1. Now the metering device 1 can be immersed in the metering position in the carrier medium storage container 5 in the metering position shown in FIG. 31 (compare FIG. Subsequently, the operator takes the mouthpiece 14 in the mouth and sucks on it as on a straw. As a result of the resulting negative pressure in the interior 12 of the piston body 9, on the one hand the preparation 2 from the storage space 21 is sucked into the interior 12 of the piston body 9. Since the storage space 21 is in fluid communication with the carrier medium 4 via the access opening 8, the carrier medium 4 is sucked through the access opening 8 into the storage space 21 and also into the interior 12 of the piston body 9 through the access opening 8. In this passage of the preparation 2 and the support medium 4 through the passage opening 1 1 into the interior 12 of the piston body 9, the one-way valve 16 acts in the passage or release direction. The preparation 2 and the carrier medium 4 then mix inside the piston body 9. The operator then sucks in a mixture of the preparation 2 and the carrier medium 4 through the outlet opening 13.

Depending on the metered quantity of the preparation 2, this mixture may be a preparation 2 diluted to a greater or lesser extent with the carrier medium 4. In particular, an unpleasant taste of the preparation 2 can be covered by a corresponding taste of the support medium 4 in this way. At the same time an exact dosage of the preparation 2 is ensured by the metering device 1. After administration of the preparation 2, the dosing device 1 can be easily rinsed with tap water, for example. The rinsed and dried dosing device 1 can then be stored and reused for a new administration of the preparation 2, as explained above.

The various components of the devices according to the invention explained above are made of plastic. Preferred materials for these components are polypropylene (PP), polyethylene (PE), acrylonitrile-butadiene-styrene copolymers (ABS), cycloolene copolymers (COC), styrene polymers and copolymers (PS) and polyoxymethylenes (POM). , The cylinder body 6 is preferably made of a transparent or translucent PP, alternatively made of a transparent or translucent ABS, PE or COC. The piston body 9 is preferably made of a naturally colored or colored PE, alternatively of a PP or an ABS. The one-way valve 16 is preferably made of a natural-colored or colored silicone (SIK), alternatively made of a thermoplastic elastomer (TEP). The counter stop body 43, 52, 62 is preferably made of a natural or colored PP, alternatively of a PE, ABS, of a styrene polymer or a styrene copolymer. In a clip embodiment of the counter-stop body 43, 52, 62, this can be made of natural-colored or colored POM, alternatively of ABS, styrene copolymers or P.

Claims

claims

A metering device (22, 38, 49, 61, 68) for the metered administration of a flowable preparation (2) together with a flowable carrier medium (4), with a storage container (6) for the preparation (2), which has at least one Access opening (8) communicates with the environment, with a piston body (9) which is sealed in the reservoir (6) is displaced between

- A starting position in which the piston body (9) is fully inserted into the reservoir (6), and

- A metering position in which the piston body (9) to a desired dosage of the preparation (2) corresponding Wegstrecke (W) is pulled out of the reservoir (6), wherein the piston body (9) is hollow and a fluid connection free gives in between

- A passage opening (1 1) between the reservoir (6) and an interior (12) of the piston body (9), and

- An accessible suction port (13) of the piston body

(9), wherein in the passage opening (1 1) a one-way valve (16) is arranged, which releases a fluid path from the reservoir (6) in the piston body interior (12) and locks in the opposite direction, with a Hubbegrenzungseinrichtung (23; ; 50; 62) for limiting the piston-body stroke between the starting position and at least two metering positions extending in the path (W) distinguish between the starting position and the respective dosing position.

2. Metering device according to claim 1, characterized in that the stroke limiting device (23; 39; 50; 63) limits the piston body stroke between the starting position and more than two metering positions, in particular more than three metering positions and in particular four metering positions.

3. Dosing device according to claim 1 or 2, characterized in that the Hubbegrenzungseinrichtung (23; 39; 50; 63) at least one piston-fixed stop (33; 40 to 42; 51), in particular a stop collar (51), which zur Dosierposition- Setting with a container-fixed counter-stop (25 to 29; 43; 52; 62) cooperates.

4. Dosing device according to claim 3, characterized in that the counter-stop (43; 52; 62) is designed as a switchable between several stop positions counter stop body.

5. Metering device according to claim 4, characterized in that the counter-stop body (52, 62) on the reservoir (6) secured and represents this separate component.

6. Dosing device according to claim 5, characterized by a passage opening (58; 65) in the storage container (6), through which the counter stop body (52; 62) is guided.

7. Metering device according to claim 6, characterized by a plurality of passage openings (65) in the connecting body (6), each associated with a stop position of the counter-stop body (62).

8. Metering device according to one of claims 5 to 7, characterized in that the counter stop body (62) on a reservoir (6) surrounding the ring (69) is integrally formed.

9. Metering device according to claim 8, characterized in that an inner width of the ring (69) is greater than that of the ring (69) surrounded outer diameter of the reservoir (6), that the ring (69) in to a longitudinal extent of the reservoir (6 ) radial direction between a stop position and a disassembly position can be displaced, in which the container-fixed counter stop comes from the piston-fixed stop.

10. Metering device according to one of claims 5 to 7, characterized in that the counter stop body (52) has a more than half the circumference of the reservoir (6) surrounding ring portion (67) has up.

1 1. Metering device according to one of claims 6 to 10, characterized in that the at least one passage opening (65) in a peripheral portion (76) of the reservoir (6) is formed, the wall of an outer shell of the piston body (9) arranged spaced is, so that between the outer circumferential wall of the piston body (9) and the spaced peripheral portion (76) is a gap into which the counter stop body (62) or a stopper portion (64) of these can be arranged in a disassembly position.

12. Dosing device according to one of claims 6 to 1 1, characterized in that the counter-stop body (62) is made of an elastic material and has a tapering on insertion to the passage opening (65) shape, wherein a portion of the counter-impact body (62) whose extension is greater than that of the passage opening (65), a recess (66) connects, which represents an undercut in the inserted position of the counter stop body (62) in the passage opening (65) of the reservoir (6).

13. Dosing device according to one of claims 4 to 12, characterized in that the counter stop body (52) has at least one latching tongue (56) which cooperates with a latching receptacle (57) in the reservoir (6) and is displaceable between a latching position and a release position wherein the counter stop body (52) is biased in the detent position.

14. Dosing device according to claim 13, characterized in that the counter stop body (52) made of an elastic material and is formed so that the bias voltage is a result of the geometry and the elasticity of the material of the counter stop body (52).

15. Metering device according to claim 13 or 14, characterized in that the counter stop body (52) has a pair of opposing latching tongues (56) which cooperate at the same axial height with a corresponding pair of opposing latching receptacles (57) in the reservoir (6).

16. Metering device according to one of claims 13 to 15, characterized by a plurality of latching receptacles (57) or Rastaufnahme- pairs, wherein each one of the latching receptacles (57) or one of the locking receptacle pairs with the latching tongue (56) or the latching tongue pair to cooperate with one of the metering positions.

17. Metering device according to one of claims 1 to 16, characterized in that the Hubbegrenzungseinrichtung (39) has a plurality of piston-fixed stops (40 to 42) distributed in the circumferential direction around the piston body (9) and axially offset from each other and to Dosing position adjustment with a container-fixed counter-stop (43) cooperate.

18. Dosing device according to one of claims 1, 3 to 17, character- ized in that the counter-stop is formed as between a stop position and a neutral position reversible counter stop body (43).

19. Metering device according to claim 18, characterized in that the counter stop body (43) is latched in the stop position on the storage container (6).

20. Metering device according to claim 18 or 19, characterized in that the counter stop body (43) via a solid-body joint (45) with the reservoir (6) is connected.

21. Metering device according to one of claims 18 to 20, characterized by a passage opening (47) in the reservoir (6), through which the counter stop body (43) passes during the displacement of the neutral position in the stop position.

22. Metering device according to one of claims 17 to 21, characterized by a plurality of counter-stop bodies (43), each associated with one of the stops (40 to 42).

23. Metering device according to claim 22, characterized in that the counter stop body (43) on a common circumferential collar (44) of the reservoir (6) are arranged.

24. Dosing device according to one of claims 1 to 23, character- ized in that the stroke limiting device (23) has a sleeve (24) with a number of metering positions corresponding number of stop or locking elements (25 to 29), in the circumferential direction the sleeve (24) are arranged distributed, wherein for adjusting the metering positions of the stop or locking elements (25 to 29) cooperates with a relative to this displaceable counter-stop or latching element (33).

25. Metering device according to claim 24, characterized in that the latching elements are formed as in the sleeve (24) shaped latching recesses into which the counter-latching element (33) can engage for latching interaction.

26. Metering device according to claim 24 or 25, characterized in that the sleeve (24) between the reservoir (6) and the piston body (9) is arranged.

27. Metering device according to one of claims 24 to 26, characterized in that the sleeve (24) with the reservoir (6) is positively connected and in particular locked with this.

28. Metering device according to one of claims 24 to 27, characterized by a rotation lock (34, 35) for securing a Relatiwerdre- hung the sleeve (24) to the counter-stop or latching element (33).

29. A method for filling the metering device (22; 38; 49; 61; 68) according to one of claims 1 to 28, comprising the following steps: - setting the stroke limiting device (23; 39; 50; 62) for limiting the piston body stroke between the Starting position and a predetermined dosing position,

Immersing the access opening (8) of the storage container (6) in a preparation storage container (3) with the piston body (9) in the starting position,

Moving the piston body (9) in the metering position.

30. A substance for use in a method for oral administration of this substance to a person, wherein the substance is administered by means of a metering device according to any one of claims 1 to 28.

31. Use of a dosing device according to any one of claims 1 to 28 for the preparation of a delivery container for the treatment of diseases which are treatable by means of an oral administration of a preparation.