WO2010034160A1 - 覆硒碱式氯化铜的制备方法及用途 - Google Patents
覆硒碱式氯化铜的制备方法及用途 Download PDFInfo
- Publication number
- WO2010034160A1 WO2010034160A1 PCT/CN2008/072563 CN2008072563W WO2010034160A1 WO 2010034160 A1 WO2010034160 A1 WO 2010034160A1 CN 2008072563 W CN2008072563 W CN 2008072563W WO 2010034160 A1 WO2010034160 A1 WO 2010034160A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- copper chloride
- selenium
- basic copper
- basic
- chloride
- Prior art date
Links
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 229910052711 selenium Inorganic materials 0.000 title claims abstract description 104
- 239000011669 selenium Substances 0.000 title claims abstract description 104
- ORTQZVOHEJQUHG-UHFFFAOYSA-L copper(II) chloride Chemical compound Cl[Cu]Cl ORTQZVOHEJQUHG-UHFFFAOYSA-L 0.000 title claims abstract description 83
- 238000002360 preparation method Methods 0.000 title claims abstract description 13
- 241001465754 Metazoa Species 0.000 claims abstract description 24
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract description 21
- 238000000034 method Methods 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 16
- 238000006243 chemical reaction Methods 0.000 claims abstract description 14
- JNRBLFVQPTZFAG-UHFFFAOYSA-L copper;selenite Chemical compound [Cu+2].[O-][Se]([O-])=O JNRBLFVQPTZFAG-UHFFFAOYSA-L 0.000 claims abstract description 13
- 239000013078 crystal Substances 0.000 claims abstract description 13
- 239000003381 stabilizer Substances 0.000 claims abstract description 8
- 238000003756 stirring Methods 0.000 claims abstract description 8
- LITQZINTSYBKIU-UHFFFAOYSA-F tetracopper;hexahydroxide;sulfate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Cu+2].[Cu+2].[Cu+2].[Cu+2].[O-]S([O-])(=O)=O LITQZINTSYBKIU-UHFFFAOYSA-F 0.000 claims abstract description 7
- 239000000654 additive Substances 0.000 claims abstract description 5
- 230000000996 additive effect Effects 0.000 claims abstract description 5
- 238000005406 washing Methods 0.000 claims abstract description 5
- JZCCFEFSEZPSOG-UHFFFAOYSA-L copper(II) sulfate pentahydrate Chemical compound O.O.O.O.O.[Cu+2].[O-]S([O-])(=O)=O JZCCFEFSEZPSOG-UHFFFAOYSA-L 0.000 claims abstract description 4
- 238000007599 discharging Methods 0.000 claims abstract description 4
- MCAHWIHFGHIESP-UHFFFAOYSA-N selenous acid Chemical compound O[Se](O)=O MCAHWIHFGHIESP-UHFFFAOYSA-N 0.000 claims abstract description 3
- 238000004519 manufacturing process Methods 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 7
- 239000011573 trace mineral Substances 0.000 claims description 7
- 235000013619 trace mineral Nutrition 0.000 claims description 7
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 6
- 150000001875 compounds Chemical class 0.000 claims description 5
- PTVDYARBVCBHSL-UHFFFAOYSA-N copper;hydrate Chemical compound O.[Cu] PTVDYARBVCBHSL-UHFFFAOYSA-N 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 claims description 3
- 235000011187 glycerol Nutrition 0.000 claims description 3
- 238000003828 vacuum filtration Methods 0.000 claims description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
- 239000003513 alkali Substances 0.000 claims description 2
- 229910000365 copper sulfate Inorganic materials 0.000 claims description 2
- 239000000600 sorbitol Substances 0.000 claims description 2
- KXIGCJSORWZFHJ-UHFFFAOYSA-K Cl(=O)[O-].[Bi+3].Cl(=O)[O-].Cl(=O)[O-] Chemical compound Cl(=O)[O-].[Bi+3].Cl(=O)[O-].Cl(=O)[O-] KXIGCJSORWZFHJ-UHFFFAOYSA-K 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract description 11
- 238000001035 drying Methods 0.000 abstract description 3
- 238000001914 filtration Methods 0.000 abstract 2
- 238000005086 pumping Methods 0.000 abstract 2
- 229940000207 selenious acid Drugs 0.000 abstract 1
- 229940091258 selenium supplement Drugs 0.000 description 97
- 239000010949 copper Substances 0.000 description 24
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 15
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 14
- 229910052802 copper Inorganic materials 0.000 description 14
- 229960001471 sodium selenite Drugs 0.000 description 13
- 239000011781 sodium selenite Substances 0.000 description 13
- 235000015921 sodium selenite Nutrition 0.000 description 13
- 230000000694 effects Effects 0.000 description 9
- 239000012071 phase Substances 0.000 description 7
- 239000000843 powder Substances 0.000 description 7
- 230000008569 process Effects 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 239000006053 animal diet Substances 0.000 description 5
- 239000000460 chlorine Substances 0.000 description 5
- 229940082569 selenite Drugs 0.000 description 5
- MCAHWIHFGHIESP-UHFFFAOYSA-L selenite(2-) Chemical compound [O-][Se]([O-])=O MCAHWIHFGHIESP-UHFFFAOYSA-L 0.000 description 5
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 4
- 239000003929 acidic solution Substances 0.000 description 4
- 230000002411 adverse Effects 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 229910052500 inorganic mineral Inorganic materials 0.000 description 4
- 235000010755 mineral Nutrition 0.000 description 4
- 239000011707 mineral Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 241000282849 Ruminantia Species 0.000 description 3
- 241000282887 Suidae Species 0.000 description 3
- 239000005862 Whey Substances 0.000 description 3
- 102000007544 Whey Proteins Human genes 0.000 description 3
- 108010046377 Whey Proteins Proteins 0.000 description 3
- 238000010521 absorption reaction Methods 0.000 description 3
- 238000004458 analytical method Methods 0.000 description 3
- 239000003674 animal food additive Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 235000005911 diet Nutrition 0.000 description 3
- 230000037213 diet Effects 0.000 description 3
- 239000006185 dispersion Substances 0.000 description 3
- -1 lipid peroxides Chemical class 0.000 description 3
- 210000004185 liver Anatomy 0.000 description 3
- 230000002468 redox effect Effects 0.000 description 3
- IRPLSAGFWHCJIQ-UHFFFAOYSA-N selanylidenecopper Chemical compound [Se]=[Cu] IRPLSAGFWHCJIQ-UHFFFAOYSA-N 0.000 description 3
- 239000008399 tap water Substances 0.000 description 3
- 235000020679 tap water Nutrition 0.000 description 3
- YWYZEGXAUVWDED-UHFFFAOYSA-N triammonium citrate Chemical compound [NH4+].[NH4+].[NH4+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O YWYZEGXAUVWDED-UHFFFAOYSA-N 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
- 102000006587 Glutathione peroxidase Human genes 0.000 description 2
- 108700016172 Glutathione peroxidases Proteins 0.000 description 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 235000019730 animal feed additive Nutrition 0.000 description 2
- 239000007864 aqueous solution Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 229910052797 bismuth Inorganic materials 0.000 description 2
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 2
- 229910001919 chlorite Inorganic materials 0.000 description 2
- 229910052619 chlorite group Inorganic materials 0.000 description 2
- QBWCMBCROVPCKQ-UHFFFAOYSA-N chlorous acid Chemical compound OCl=O QBWCMBCROVPCKQ-UHFFFAOYSA-N 0.000 description 2
- 239000007979 citrate buffer Substances 0.000 description 2
- 239000002131 composite material Substances 0.000 description 2
- 210000003298 dental enamel Anatomy 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 239000011785 micronutrient Substances 0.000 description 2
- 235000013369 micronutrients Nutrition 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000572 poisoning Toxicity 0.000 description 2
- 230000000607 poisoning effect Effects 0.000 description 2
- 238000012545 processing Methods 0.000 description 2
- 210000004767 rumen Anatomy 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000000967 suction filtration Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000003440 toxic substance Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- PMYDPQQPEAYXKD-UHFFFAOYSA-N 3-hydroxy-n-naphthalen-2-ylnaphthalene-2-carboxamide Chemical compound C1=CC=CC2=CC(NC(=O)C3=CC4=CC=CC=C4C=C3O)=CC=C21 PMYDPQQPEAYXKD-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- QPLDLSVMHZLSFG-UHFFFAOYSA-N Copper oxide Chemical compound [Cu]=O QPLDLSVMHZLSFG-UHFFFAOYSA-N 0.000 description 1
- 239000005751 Copper oxide Substances 0.000 description 1
- JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 1
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 210000001744 T-lymphocyte Anatomy 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- NGMTUCFCIUGWAG-UHFFFAOYSA-L [Cu+2].[O-]Cl=O.[O-]Cl=O Chemical compound [Cu+2].[O-]Cl=O.[O-]Cl=O NGMTUCFCIUGWAG-UHFFFAOYSA-L 0.000 description 1
- SWZCHAYJQXALJO-UHFFFAOYSA-N [Cu].C(Cl)(Cl)Cl Chemical compound [Cu].C(Cl)(Cl)Cl SWZCHAYJQXALJO-UHFFFAOYSA-N 0.000 description 1
- PAYGZWVOSMLEBM-UHFFFAOYSA-N [Se](Cl)Cl.[Se] Chemical compound [Se](Cl)Cl.[Se] PAYGZWVOSMLEBM-UHFFFAOYSA-N 0.000 description 1
- IRNJZJVYWUJAAS-UHFFFAOYSA-L [Se].[Cu](Cl)Cl Chemical compound [Se].[Cu](Cl)Cl IRNJZJVYWUJAAS-UHFFFAOYSA-L 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 238000005054 agglomeration Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 150000001447 alkali salts Chemical class 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229910052793 cadmium Inorganic materials 0.000 description 1
- BDOSMKKIYDKNTQ-UHFFFAOYSA-N cadmium atom Chemical compound [Cd] BDOSMKKIYDKNTQ-UHFFFAOYSA-N 0.000 description 1
- 230000036996 cardiovascular health Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 231100000481 chemical toxicant Toxicity 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 229910001431 copper ion Inorganic materials 0.000 description 1
- 229910000431 copper oxide Inorganic materials 0.000 description 1
- RGZGHMSJVAQDQO-UHFFFAOYSA-L copper;selenate Chemical compound [Cu+2].[O-][Se]([O-])(=O)=O RGZGHMSJVAQDQO-UHFFFAOYSA-L 0.000 description 1
- 230000007123 defense Effects 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000006911 enzymatic reaction Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 235000013312 flour Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 239000004519 grease Substances 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 230000003394 haemopoietic effect Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 239000001257 hydrogen Substances 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 230000036737 immune function Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 230000003780 keratinization Effects 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 238000002372 labelling Methods 0.000 description 1
- 239000007791 liquid phase Substances 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 229910052748 manganese Inorganic materials 0.000 description 1
- 239000011572 manganese Substances 0.000 description 1
- 230000035800 maturation Effects 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 1
- 229910052753 mercury Inorganic materials 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 229910052750 molybdenum Inorganic materials 0.000 description 1
- 239000011733 molybdenum Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 230000011164 ossification Effects 0.000 description 1
- 231100000255 pathogenic effect Toxicity 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 230000037361 pathway Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 230000019612 pigmentation Effects 0.000 description 1
- 238000003044 randomized block design Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000001850 reproductive effect Effects 0.000 description 1
- QYHFIVBSNOWOCQ-UHFFFAOYSA-N selenic acid Chemical compound O[Se](O)(=O)=O QYHFIVBSNOWOCQ-UHFFFAOYSA-N 0.000 description 1
- 150000003342 selenium Chemical class 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- KKCBUQHMOMHUOY-UHFFFAOYSA-N sodium oxide Chemical compound [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 description 1
- 229910001948 sodium oxide Inorganic materials 0.000 description 1
- 239000011655 sodium selenate Substances 0.000 description 1
- 229960001881 sodium selenate Drugs 0.000 description 1
- 235000018716 sodium selenate Nutrition 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 231100000167 toxic agent Toxicity 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B19/00—Selenium; Tellurium; Compounds thereof
- C01B19/007—Tellurides or selenides of metals
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/24—Compounds of alkaline earth metals, e.g. magnesium
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/30—Oligoelements
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
- C01B19/00—Selenium; Tellurium; Compounds thereof
- C01B19/02—Elemental selenium or tellurium
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G3/00—Compounds of copper
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G3/00—Compounds of copper
- C01G3/04—Halides
- C01G3/05—Chlorides
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
- C01G3/00—Compounds of copper
- C01G3/10—Sulfates
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/60—Particles characterised by their size
- C01P2004/61—Micrometer sized, i.e. from 1-100 micrometer
-
- C—CHEMISTRY; METALLURGY
- C01—INORGANIC CHEMISTRY
- C01P—INDEXING SCHEME RELATING TO STRUCTURAL AND PHYSICAL ASPECTS OF SOLID INORGANIC COMPOUNDS
- C01P2004/00—Particle morphology
- C01P2004/80—Particles consisting of a mixture of two or more inorganic phases
- C01P2004/82—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases
- C01P2004/84—Particles consisting of a mixture of two or more inorganic phases two phases having the same anion, e.g. both oxidic phases one phase coated with the other
Definitions
- the present invention relates to a process for the preparation of a compound, and more particularly to a process for the preparation and use of a selenium-containing copper chloride.
- the biological effects of selenium in animals are: (1) Selenium sequestases lipid peroxides by glutathione peroxidase enzymatic reaction, blocking the pathogenic effects of reactive oxygen species and free radicals, and Together with vitamin E, it constitutes two defense pathways for animal body antioxidants, which work synergistically; (2) Selenium can protect and maintain the integrity of the immune system and enhance the humoral and cellular immune functions of animals and humans; Promote and maintain animal reproductive performance, which is necessary for male animals to produce sperm; (4) Enhance T cell-mediated tumor-specific immunity, enhance anticancer effects, and regulate thyroid to maintain normal physiological functions; (5) Selenium can antagonize the toxic effects of certain heavy metal elements such as arsenic, mercury and cadmium on the body; (6) Promote growth, maintain cardiovascular health, and maintain the normal function of visual organs.
- the selenium feed additives allowed in China are sodium selenite and yeast selenium.
- Sodium selenite is inexpensive and contains a high amount of selenium.
- it is a highly toxic chemical. It is difficult to control the dosage and has a redox effect, which will adversely affect animals and the environment. Therefore, China stipulates that selenium must be in the form of premix in animal diets.
- the amount of selenium in the selenium premix is generally about 200 mg/kg.
- Organic selenium such as yeast selenium has high absorption rate and low toxicity, and will not cause adverse effects on animals and the environment. However, the price of organic selenium is high, the selenium content is low, and the selenium content of yeast selenium is only one thousandth. Selenium content meter, the price of yeast selenium is several hundred times that of sodium selenite, and the cost of organic selenium restricts its application in feed.
- Copper participates in the hematopoietic function of the body and plays an important role in the synthesis of heme and the maturation of red blood cells.
- the oblique chlorite and the chlorite are homogeneous isomers, which are a kind of micro-moisture with good fluidity and low water solubility. They have good miscibility, which is beneficial to the compounding and processing of feed, and does not destroy the vitamins in the feed. Grease, with high bioavailability.
- selenium and copper are trace minerals that need to be added to animal feed, and both play a synergistic role in the antioxidant capacity of the organism's body.
- selenium-copper composite element feed additives especially regarding Selenium-copper composite element feed additive with good fluidity, suitable particle size, low water solubility, good physicochemical properties such as moisture agglomeration and low cost of sodium selenite. No literature has been reported yet.
- the present invention aims to solve the above problems, and provides a non-moisture-absorbing agglomerate, which has good fluidity, stable chemical properties, easy feed mix, low price, low added cost, weak acid solubility, and easy absorption and utilization.
- a method for preparing selenium basic copper chloride is a method for preparing selenium basic copper chloride.
- the present invention provides a method for preparing a selenium-containing basic copper chloride, which comprises the following steps:
- Crystalline basic copper chloride is an orthorhombic chloroformite (atacamite), a trigonal system of para-aluminum (par atacamite), and a monoclinic system of borallackite.
- atacamite orthorhombic chloroformite
- par atacamite trigonal system of para-aluminum
- monoclinic system of borallackite One or several mixed crystal forms.
- Crystalline basic copper chloride is a round particle of 30 to 200 microns.
- Stabilizers are organic polyhydroxy compounds.
- Stabilizers are glycerol, ethylene glycol, sorbitol.
- the concentration of the sodium hydroxide solution is 5 to 25%.
- FIG. 2 The structure of the selenium-containing basic copper chloride prepared by the above method is as shown in FIG. 2, wherein the basic copper chloride 1 is located at the center, and the basic copper selenite 2 is coated on the outside. The outer layer of copper selenite is coated with basic copper sulfate 3.
- the present invention also provides the use of the selenium-containing basic copper chloride prepared by the above method, and the selenium-containing basic copper chloride prepared by the preparation method of the present invention can be used as an animal feed trace element additive.
- the ratio of the selenium-copper-based element of the selenium-based copper chloride in accordance with the present invention is in the range of 0. 1 ⁇ 10: 100
- the copper content of the selenium-containing copper chloride is 50 ⁇ 59%, and the selenium content is 0.5 ⁇ 5%. Therefore, the selenium-containing copper chloride is a basic copper chloride.
- basic copper selenite is a dilution of the active ingredient of selenium, which contributes to the dispersion of selenium in animal diets.
- the contribution of the present invention is that it effectively overcomes the problems that sodium selenite is highly toxic, easy to absorb moisture, difficult to use, chemically active, has redox effect, and has adverse effects on animals and the environment.
- the selenium-containing basic copper chloride prepared by the method of the invention has good fluidity, is insoluble in water, and is suitable for feed ingredients. Since selenium is present as a water-insoluble basic salt of selenite and is encapsulated in the middle of the complex by basic copper sulfate, it is low in toxicity, does not chemically react with other components in the feed, and has no redox properties. Chemically stable.
- the selenium-containing copper chloride of the present invention is used as an additive for trace elements in animal feed, and has good biocompatibility and does not adversely affect the environment. Therefore, it can be commonly used in animal feed.
- FIG. 1 is a schematic view showing the process route of the preparation method of the present invention.
- FIG. 2 is a schematic view showing the structure of a selenium-containing basic copper chloride prepared by the method of the present invention.
- reaction temperature is reacted for 1 hour to a P H value of 9, and then discharged to a vacuum suction filter for suction filtration, followed by washing with tap water and suction filtration to dryness to obtain a hydroxyl group-modified crystalline phase basic copper chloride. Then add the hydroxyl modified crystal phase basic copper chloride to the 2 M3 enamel reaction tank, inject 1500 liters of tap water, stir and react temperature 30 ⁇ 60
- Selenium-based copper chloride is a water-insoluble blue-green powder with a good fluidity of 30 to 200 ⁇ m.
- the coefficient of variation of the selenium content of the compound feed produced by the formula 1 and the formula 2 premix is determined to be 20% and 5.8%, respectively, to use the selenium-containing basic chlorine.
- the copper-blended feed greatly improves the dispersibility of selenium in the feed compared with the feed using sodium selenite.
- a total of 60 ternary hybrid weaned piglets (half male and female) weighing 30 days of weaning and weighing 7.5 kg were selected for the study of selenite-based copper chloride relative to (sodium selenite and
- the trials were designed with a completely randomized block design. 60 weaned piglets were randomly divided into 5 treatment groups according to body weight, sex, and litter size. Treatment group 1 did not add selenium and added basic copper chloride 150.
- Treatment group 4 ⁇ 5 is added with selenium-based copper chloride 0.3, 0.5 mg/kg two selenium levels and 150 mg/kg
- the trial period is 35 days, including a 7-day pre-test period and a 28-day formal trial period.
- the growth performance of finishing pigs in the horizontal range was not significant, and the daily gain and the weight-to-weight ratio were significantly increased compared with the control group, indicating that the selenium-selenium chloride was safe and effective and could promote the growth performance;
- the activity and SOD activity of GSH-Px in whole blood were significantly higher than that in the control group.
- the MDA content in the serum of the selenium-containing copper chloride group was significantly lower than that in the control group, which was lower than that in the sodium selenite group. It indicates that the selenium-containing copper chloride bis-sodium selenate has better antioxidant activity to the body;
- the selenium content in the liver and kidney of the four selenium supplementation groups was significantly higher than that of the control group, of which 0.3
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CN105236469A (zh) * | 2015-09-17 | 2016-01-13 | 长沙兴嘉生物工程股份有限公司 | 亚硒酸铜/锌的制备方法及其应用 |
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CN1528171A (zh) * | 2003-10-16 | 2004-09-15 | 黄逸强 | 碱式氯化铜饲料添加剂及其制备方法 |
CN101372354A (zh) * | 2008-09-03 | 2009-02-25 | 深圳市危险废物处理站有限公司 | 覆硒碱式氯化铜的制备方法及用途 |
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US4659555A (en) * | 1984-05-12 | 1987-04-21 | Th. Goldschmidt Ag 03 | Process for the preparation of basic copper carbonate |
CN1528171A (zh) * | 2003-10-16 | 2004-09-15 | 黄逸强 | 碱式氯化铜饲料添加剂及其制备方法 |
CN101372354A (zh) * | 2008-09-03 | 2009-02-25 | 深圳市危险废物处理站有限公司 | 覆硒碱式氯化铜的制备方法及用途 |
Cited By (8)
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CN105329933A (zh) * | 2015-11-20 | 2016-02-17 | 厦门成斯涞科技有限公司 | 一种碱式氯化铜晶体的制备方法及其用途 |
CN105347384A (zh) * | 2015-11-20 | 2016-02-24 | 厦门成斯涞科技有限公司 | 一种碱式氯化铜同分异构体的制备方法及其用途 |
CN111642633A (zh) * | 2020-07-07 | 2020-09-11 | 武汉轻工大学 | 碱式氯化铜微球及其制备方法、以及饲料添加剂 |
CN111642633B (zh) * | 2020-07-07 | 2023-01-06 | 武汉轻工大学 | 碱式氯化铜微球及其制备方法、以及饲料添加剂 |
CN112916025A (zh) * | 2021-01-22 | 2021-06-08 | 西南石油大学 | 一种羟基氯铜催化剂、制备方法及应用 |
CN113603130A (zh) * | 2021-08-17 | 2021-11-05 | 湖南德邦生物科技有限公司 | 一种碱式氯化铜合成中的晶体改性的制备方法 |
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