WO2010025287A9 - Polypeptides cétoréductases pour la production de 3-aryl-3-hydroxypropanamine à partir de a 3-aryl-3-cétopropanamine - Google Patents

Polypeptides cétoréductases pour la production de 3-aryl-3-hydroxypropanamine à partir de a 3-aryl-3-cétopropanamine Download PDF

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Publication number
WO2010025287A9
WO2010025287A9 PCT/US2009/055239 US2009055239W WO2010025287A9 WO 2010025287 A9 WO2010025287 A9 WO 2010025287A9 US 2009055239 W US2009055239 W US 2009055239W WO 2010025287 A9 WO2010025287 A9 WO 2010025287A9
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WO
WIPO (PCT)
Prior art keywords
aryl
ketopropanamine
hydroxypropanamine
production
ketoreductase polypeptides
Prior art date
Application number
PCT/US2009/055239
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English (en)
Other versions
WO2010025287A2 (fr
Inventor
Christopher Savile
John M. Gruber
Emily Mundorff
Gjalt W. Huisman
Steven J. Collier
Original Assignee
Codexis, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Codexis, Inc. filed Critical Codexis, Inc.
Publication of WO2010025287A2 publication Critical patent/WO2010025287A2/fr
Publication of WO2010025287A9 publication Critical patent/WO2010025287A9/fr

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01164—Hexadecanol dehydrogenase (1.1.1.164)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01184—Carbonyl reductase (NADPH) (1.1.1.184)

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
PCT/US2009/055239 2008-08-27 2009-08-27 Polypeptides cétoréductases pour la production de 3-aryl-3-hydroxypropanamine à partir de a 3-aryl-3-cétopropanamine WO2010025287A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US9233108P 2008-08-27 2008-08-27
US61/092,331 2008-08-27

Publications (2)

Publication Number Publication Date
WO2010025287A2 WO2010025287A2 (fr) 2010-03-04
WO2010025287A9 true WO2010025287A9 (fr) 2010-05-27

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PCT/US2009/055239 WO2010025287A2 (fr) 2008-08-27 2009-08-27 Polypeptides cétoréductases pour la production de 3-aryl-3-hydroxypropanamine à partir de a 3-aryl-3-cétopropanamine

Country Status (2)

Country Link
US (8) US8288141B2 (fr)
WO (1) WO2010025287A2 (fr)

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EP2467473B1 (fr) 2009-08-19 2016-03-23 Codexis, Inc. Polypeptides de kétoréductase pour la préparation de phényléphrine
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JP6719463B2 (ja) 2014-11-25 2020-07-15 コデクシス， インコーポレイテッド ケトン化合物およびアミン化合物の還元的アミノ化のための操作されたイミンレダクターゼおよび方法
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Publication number Publication date
WO2010025287A2 (fr) 2010-03-04
US9228213B2 (en) 2016-01-05
US11512332B2 (en) 2022-11-29
US20200340025A1 (en) 2020-10-29
US20170226546A1 (en) 2017-08-10
US20230104779A1 (en) 2023-04-06
US8288141B2 (en) 2012-10-16
US9657320B2 (en) 2017-05-23
US10006069B2 (en) 2018-06-26
US8877475B2 (en) 2014-11-04
US20100173369A1 (en) 2010-07-08
US10752926B2 (en) 2020-08-25
US20180251802A1 (en) 2018-09-06
US20150031094A1 (en) 2015-01-29
US20160083759A1 (en) 2016-03-24
US20130005017A1 (en) 2013-01-03

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