AU2003253036A1 - Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol - Google Patents

Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol

Info

Publication number
AU2003253036A1
AU2003253036A1 AU2003253036A AU2003253036A AU2003253036A1 AU 2003253036 A1 AU2003253036 A1 AU 2003253036A1 AU 2003253036 A AU2003253036 A AU 2003253036A AU 2003253036 A AU2003253036 A AU 2003253036A AU 2003253036 A1 AU2003253036 A1 AU 2003253036A1
Authority
AU
Australia
Prior art keywords
methylamino
thienyl
propanol
preparation
optically active
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2003253036A
Inventor
Dominique Michel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Lonza AG
Original Assignee
Lonza AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lonza AG filed Critical Lonza AG
Publication of AU2003253036A1 publication Critical patent/AU2003253036A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
    • C07D493/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
    • C07D333/20—Radicals substituted by singly bound hetero atoms other than halogen by nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AU2003253036A 2002-07-09 2003-07-08 Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol Abandoned AU2003253036A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP02015161 2002-07-09
EP02015161.9 2002-07-09
PCT/EP2003/007312 WO2004005307A1 (en) 2002-07-09 2003-07-08 Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol

Publications (1)

Publication Number Publication Date
AU2003253036A1 true AU2003253036A1 (en) 2004-01-23

Family

ID=30011061

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2003253036A Abandoned AU2003253036A1 (en) 2002-07-09 2003-07-08 Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol

Country Status (2)

Country Link
AU (1) AU2003253036A1 (en)
WO (1) WO2004005307A1 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1566383A1 (en) * 2004-02-19 2005-08-24 Lonza AG Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
AU2005215906C1 (en) * 2004-02-19 2012-03-01 Lonza Ag Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
DE102005000867A1 (en) * 2005-01-05 2006-07-13 Basf Ag Process for the purification of (1S) -3-methylamino-1- (2-thienyl) -1-propanol
CN101124196B (en) * 2005-02-21 2011-05-11 隆萨股份公司 Process for the preparation of enantiomerically pure 1-substituted-3-aminoalcohols
US20100280093A1 (en) 2006-07-03 2010-11-04 Ranbaxy Laboratories Limited Process for the preparation enantiomerically pure salts of n-methyl-3-(1-naphthaleneoxy)-3-(2-thienyl)propanamine
CN101657438A (en) 2006-12-22 2010-02-24 斯索恩有限公司 The method for preparing duloxetine and related compound
HU227730B1 (en) 2006-12-22 2012-01-30 Richter Gedeon Nyrt Process for the preparation of duloxetine and for their the intermediates
WO2010025287A2 (en) 2008-08-27 2010-03-04 Codexis, Inc. Ketoreductase polypeptides for the production of 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
HUE026181T2 (en) 2008-08-27 2016-05-30 Codexis Inc Ketoreductase polypeptides for the production of a 3-aryl-3-hydroxypropanamine from a 3-aryl-3-ketopropanamine
WO2011033366A2 (en) 2009-09-16 2011-03-24 Jubilant Life Sciences Limited Process for the preparation of duloxetine hydrochloride and its precursors
CN108341797B (en) * 2017-01-25 2021-04-27 重庆常捷医药有限公司 Synthesis method of duloxetine intermediate
CN111793056A (en) * 2020-07-27 2020-10-20 广州康瑞泰药业有限公司 Preparation method of duloxetine intermediate

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3682925A (en) * 1969-01-30 1972-08-08 Hoffmann La Roche ({31 )-di-o-isopropylidene-2-keto-l-gulonates
US4956388A (en) * 1986-12-22 1990-09-11 Eli Lilly And Company 3-aryloxy-3-substituted propanamines
US5362886A (en) * 1993-10-12 1994-11-08 Eli Lilly And Company Asymmetric synthesis

Also Published As

Publication number Publication date
WO2004005307A1 (en) 2004-01-15

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Legal Events

Date Code Title Description
MK6 Application lapsed section 142(2)(f)/reg. 8.3(3) - pct applic. not entering national phase