WO2009147178A2 - Nouvelle utilisation médicale de pyridin-2-ylméthylsulfinyl-1h-benzimidazoles substitués - Google Patents

Nouvelle utilisation médicale de pyridin-2-ylméthylsulfinyl-1h-benzimidazoles substitués Download PDF

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Publication number
WO2009147178A2
WO2009147178A2 PCT/EP2009/056824 EP2009056824W WO2009147178A2 WO 2009147178 A2 WO2009147178 A2 WO 2009147178A2 EP 2009056824 W EP2009056824 W EP 2009056824W WO 2009147178 A2 WO2009147178 A2 WO 2009147178A2
Authority
WO
WIPO (PCT)
Prior art keywords
benzimidazole
ylmethylsulphinyl
methylsulphinyl
pyridinyl
substituted pyridin
Prior art date
Application number
PCT/EP2009/056824
Other languages
English (en)
Other versions
WO2009147178A3 (fr
Inventor
Hartmut Heinze
Original Assignee
Nycomed Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Gmbh filed Critical Nycomed Gmbh
Publication of WO2009147178A2 publication Critical patent/WO2009147178A2/fr
Publication of WO2009147178A3 publication Critical patent/WO2009147178A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention porte sur une nouvelle utilisation de pyridyl-2-méthylsulfinylbenzimidazoles substitués pour le traitement et/ou la prophylaxie d'un œdème cérébral.
PCT/EP2009/056824 2008-06-04 2009-06-03 Nouvelle utilisation médicale de pyridin-2-ylméthylsulfinyl-1h-benzimidazoles substitués WO2009147178A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08157528 2008-06-04
EP08157528.4 2008-06-04

Publications (2)

Publication Number Publication Date
WO2009147178A2 true WO2009147178A2 (fr) 2009-12-10
WO2009147178A3 WO2009147178A3 (fr) 2010-03-18

Family

ID=39870104

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2009/056824 WO2009147178A2 (fr) 2008-06-04 2009-06-03 Nouvelle utilisation médicale de pyridin-2-ylméthylsulfinyl-1h-benzimidazoles substitués

Country Status (1)

Country Link
WO (1) WO2009147178A2 (fr)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074811A2 (fr) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Composes de 1,3-thiazole substitues, production et utilisation desdits composes
WO2007064274A1 (fr) * 2005-11-30 2007-06-07 Astrazeneca Ab Forme de dosage pharmaceutique pour la voie orale comprenant comme ingrédients actifs un inhibiteur de la pompe à protons ainsi que de l'acide acétylsalicylique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001074811A2 (fr) * 2000-03-30 2001-10-11 Takeda Chemical Industries, Ltd. Composes de 1,3-thiazole substitues, production et utilisation desdits composes
WO2007064274A1 (fr) * 2005-11-30 2007-06-07 Astrazeneca Ab Forme de dosage pharmaceutique pour la voie orale comprenant comme ingrédients actifs un inhibiteur de la pompe à protons ainsi que de l'acide acétylsalicylique

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JAVAHERI S ET AL: "Different effects of omeprazole and Sch 28080 on canine cerebrospinal fluid production" BRAIN RESEARCH 19970418 NL, vol. 754, no. 1-2, 18 April 1997 (1997-04-18), pages 321-324, XP007906112 ISSN: 0006-8993 *
JOCHEM V ET AL: "Fulminant hepatic failure related to omeprazole." THE AMERICAN JOURNAL OF GASTROENTEROLOGY APR 1992, vol. 87, no. 4, April 1992 (1992-04), pages 523-525, XP007906130 ISSN: 0002-9270 *
LINDVALL-AXELSSON M ET AL: "Inhibition of cerebrospinal fluid formation by omeprazole" EXPERIMENTAL NEUROLOGY, ACADEMIC PRESS, NEW YORK, NY, US, vol. 115, no. 3, 1 March 1992 (1992-03-01) , pages 394-399, XP022980519 ISSN: 0014-4886 [retrieved on 1992-03-01] *
RABINSTEIN ALEJANDRO A: "Treatment of cerebral edema" NEUROLOGIST, WLLIAMS AND WILKINS, BALTIMORE, MD, US, vol. 12, no. 2, 1 May 2006 (2006-05-01), pages 59-73, XP009107834 ISSN: 1074-7931 cited in the application *
RASLAN, BHARDWAJ: "Medical management of cerebral edema" NEUROSURG FOCUS, vol. 22, 2007, pages 1-12, XP007906107 *

Also Published As

Publication number Publication date
WO2009147178A3 (fr) 2010-03-18

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