WO2009135283A1 - Élément annexe d’emballage coque - Google Patents

Élément annexe d’emballage coque Download PDF

Info

Publication number
WO2009135283A1
WO2009135283A1 PCT/CA2008/000850 CA2008000850W WO2009135283A1 WO 2009135283 A1 WO2009135283 A1 WO 2009135283A1 CA 2008000850 W CA2008000850 W CA 2008000850W WO 2009135283 A1 WO2009135283 A1 WO 2009135283A1
Authority
WO
WIPO (PCT)
Prior art keywords
adjunct
layer
adhesive
openings
pattern
Prior art date
Application number
PCT/CA2008/000850
Other languages
English (en)
Inventor
Michael Petersen
Mykola Sherstyuk
Original Assignee
Intelligent Devices Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intelligent Devices Inc. filed Critical Intelligent Devices Inc.
Priority to PCT/CA2008/000850 priority Critical patent/WO2009135283A1/fr
Publication of WO2009135283A1 publication Critical patent/WO2009135283A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J1/00—Containers specially adapted for medical or pharmaceutical purposes
    • A61J1/03—Containers specially adapted for medical or pharmaceutical purposes for pills or tablets
    • A61J1/035—Blister-type containers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/04—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers
    • A61J7/0409—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers
    • A61J7/0427—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system
    • A61J7/0436—Arrangements for time indication or reminder for taking medicine, e.g. programmed dispensers with timers with direct interaction with a dispensing or delivery system resulting from removing a drug from, or opening, a container

Definitions

  • This invention relates to blister packages for pharmaceutical products in general and more particularly to an adjunct for use with a blister package, especially during clinical trials and when monitoring of pharmaceutical usage is important.
  • New packaging such as that available through Information Mediary Corporation makes the recording of information easier, in that the packaging provides for electrical traces printed or otherwise provided on a blister package such that a trace is broken whenever a pill or capsule is extracted from the package.
  • This event is recorded on an electronic chip included as part of the package, and the information recorded on the chip can be downloaded by the physician or other technician once all of the pills or capsules have been removed from the package.
  • the data recorded on the chip can be downloaded directly to an appropriate reader or can be transmitted wirelessly to a reader some distance away from the individual.
  • the present invention overcomes problems associated with the manufacturing of electronically monitored blister packages, particularly with respect to such packages used in clinical trials.
  • the physician conducting the trial, or having a patient on a strict medication regimen is provided with a number of package adjuncts which carry the necessary electronics and traces.
  • the conducting physician can then provide the patient or subject with an adjunct such that when the patient or subject obtains a blister package of the correct medication, whether from a pharmacy or other source, the patient or subject can then bring the blister package and the adjunct together and assemble them into a monitoring unit containing the blister package of medication and the electronic portion which provides the required usage information for later retrieval.
  • the adjunct of this invention includes a cardboard backing sheet or lidstock which typically will be printed with appropriate information and instructions for use.
  • the backing sheet will have two major portions and will be foldable so that one portion can overly the other portion.
  • One of the portions will have a plurality of openings extending therethrough arranged in a pattern which corresponds to the pattern of blisters on the blister package with which the adjunct is to be used.
  • Surrounding those openings will be a first layer of adhesive material covered by a sheet of release paper.
  • the other portion of the backing sheet will carry several layers. Specifically, there will be a second layer of adhesive material, a thin layer of plastic material, a third layer of adhesive material, an electronics layer carrying the required pattern of electrical traces and the electronic chip, and a fourth layer of adhesive material.
  • the adhesive material utilized with the present invention is preferably a gel-type adhesive that is relatively thick in comparison to most adhesives used with cardboard an other such materials.
  • the adhesive used herein has desirable properties in that it is not rigid but has a fair degree of flexibility associated therewith.
  • the layers in contact with the adhesive can shift slightly relative to each other which in turn means that the final package can be subjected to various stresses without degrading the effectiveness of the electrical traces and the electronic chip.
  • the final package can be folded, deformed, bent and otherwise stressed without the effects thereof being felt by those layers which are spaced inwardly from the cardboard backing.
  • the innermost or fourth layer of adhesive material provided on the other portion of the cardboard backing sheet will also have a release paper or sheet thereon.
  • the adhesive layers on the other portion of the backing sheet can be provided with openings, weakness zones or fracture zones to facilitate the passage of the pills or capsules therethrough from the blister package. As a pill or capsule passes through the layers of material on the other portion of the backing sheet is will break an electrical trace on the electronics layer, triggering a recording event on the electronics chip which can be later retrieved as required.
  • Figure 1 is a plan view of an adjunct in accordance with the present invention
  • Figure 2 is a cross-sectional view showing the various layers
  • Figure 3 shows the steps in assembling the final package.
  • Figures 1 and 2 show an adjunct 10 of this invention in both plan and cross-section respectively.
  • a sheet 12 of cardboard backing material has two major side portions 14, 16 with a fold line 18 separating the portions.
  • the first side portion 14 is provided with a plurality of openings 20 extending therethrough in a patter corresponding to the pattern of blisters 22 provided on a blister package 24.
  • the openings 20 are surrounded by a first layer 26 of adhesive material, the layer having a surface extent that generally corresponds to the surface extent of the blister package 24.
  • the adhesive layer 26 will be initially provided with a layer of a release paper 50 which protects the adhesive prior to usage thereof.
  • the second side portion 16 of the cardboard backing sheet is provided with a plurality of individual layers, one above the other and each being generally co-extensive with the entire surface area of the portion 16.
  • a second layer 28 of adhesive material Built up on the portion 16 of the backing sheet is a second layer 28 of adhesive material, a thin film 30 of plastic material, a third layer 32 of adhesive material, an electronics layer 34 carrying thereon the desired pattern of electrical traces and an electronics chip, and a fourth layer 36 of adhesive material.
  • the adhesive layers preferably are constituted by a gel-type of adhesive which is relatively thick in comparison to most adhesives used with cardboard materials.
  • a preferred adhesive material is available from Grafix Plastics of Cleveland, OH, USA. Such adhesive material is provided as a plastic film coated on both sides with the adhesive material and appropriate release papers.
  • the second adhesive layer 28, the plastic film 30 and the third adhesive layer 32 will, in fact, be constituted by the product obtained from Grafix Plastics as described above.
  • the adjunct 10 of this invention will use a cardboard backing sheet having a thickness in the order of 7m ⁇ l (0.175mm), adhesive layers each having a thickness in the order of 2m ⁇ l (0.05mm), a plastic film layer having a thickness in the order of 4m ⁇ l (0.1mm) and an electronics layer printed on paper having a thickness in the order of 2m ⁇ l (0.05mm).
  • the layers applied to the side portion 16, and the cardboard sheet itself will be preferably provided with either openings or zones of weakness 38 corresponding to the pattern of blisters associated with the blister package.
  • the various layers applied to portion 16 will not greatly hinder the passage of a pill or capsule therethrough.
  • Figure 3 generally shows the steps to be taken when an individual prepares a final package using the adjunct of the present invention.
  • all of the individual layers provided on the second portion of the cardboard sheet 12 are represented by the single layer 52.
  • the first step in creating a final package is for the individual to remove the release layer 50 from the adhesive material 26, exposing the adhesive for usage.
  • the blister package 24, obtained from a pharmacy, a physician, or a technician, is positioned above the adhesive layer 26 with the blisters 22 aligned with the openings 20.
  • the blister package 24 is then pressed against the adhesive layer 26 so that the blisters 22 project through the openings 20.
  • the release paper 54 covering the fourth layer of adhesive on the second portion 16 is removed and the two portions are folded towards each other around the fold line 18. That will bring the exposed adhesive of the fourth layer into contact with the back of the blister package 24 and with the adjacent surface of the first portion 14 surrounding the blister package.
  • the end result is a folded package with the blister package 24 sandwiched securely between the first and second portions of the cardboard backing sheet, with the blister 22 exposed through the openings in the first portion 14 and with the openings or zones of weakness 38 aligned with the blisters 22 as well.
  • the gel-type adhesive used for the various adhesive layers of the adjunct is relatively thick and is relatively flexible, without being rigid, there can be a small amount of relative movement between the components provided on the adjunct. This relative movement means that there is less chance of damage to, in particular, the electronics layer 34 should the final package be subjected to stress due to flexing, creasing, dropping or bending between the time of assembly and the time of data gathering.
  • adjunct packages of a standard size and configuration can be manufactured by a particular pharmaceutical company without concern as to how such packages will be provided, if desired, with electronic monitoring elements. Those elements can be manufactured elsewhere and assembled to the blister package as desired, by a physician, pharmacist or patient. This simplifies greatly the overall manufacturing and distribution process. Additionally, the adjunct of the present invention, while increasing the flexibility of clinical trials, helps to prevent damage to the final package occasioned by rough handling of the final package.

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Packages (AREA)

Abstract

La présente invention concerne un élément annexe destiné à être utilisé avec un emballage coque comportant une pluralité d’alvéoles disposés en un motif établi, chaque alvéole contenant un objet pharmaceutique. L’élément annexe comporte une feuille de support présentant des première et seconde parties latérales assemblées selon une ligne de pliage, une pluralité d’ouvertures s’étendant à travers la première partie latérale dans un motif correspondant à un motif d’alvéoles de l’emballage coque, une première couche de matériau adhésif entourant les ouvertures, une seconde couche de matériau adhésif recouvrant la seconde partie latérale de la feuille de support, un film mince de matière plastique recouvrant la seconde couche de matériau adhésif, une troisième couche de matériau adhésif recouvrant le film de matière plastique, une feuille électronique de la troisième couche de matériau adhésif et portant des impressions conductrices d’électricité et une puce électronique, les impressions conductrices s’étendant dans un motif correspondant au motif des ouvertures dans la première partie latérale de la feuille de support, et une quatrième couche de matériau adhésif recouvrant la feuille électronique. Chacune des première et quatrième couches de matériau adhésif est recouverte préalablement à l’utilisation de l’élément annexe par une feuille de matériau de déblocage.
PCT/CA2008/000850 2008-05-06 2008-05-06 Élément annexe d’emballage coque WO2009135283A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
PCT/CA2008/000850 WO2009135283A1 (fr) 2008-05-06 2008-05-06 Élément annexe d’emballage coque

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/CA2008/000850 WO2009135283A1 (fr) 2008-05-06 2008-05-06 Élément annexe d’emballage coque

Publications (1)

Publication Number Publication Date
WO2009135283A1 true WO2009135283A1 (fr) 2009-11-12

Family

ID=41264353

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2008/000850 WO2009135283A1 (fr) 2008-05-06 2008-05-06 Élément annexe d’emballage coque

Country Status (1)

Country Link
WO (1) WO2009135283A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112011103562T5 (de) 2010-10-27 2013-08-08 Intelligent Devices, Inc. Einwegeinnahmeüberwachungspackung mit abnehmbarer wiederverwendbarer elektronischer Schaltplatte
US10278287B2 (en) 2012-04-25 2019-04-30 Intelligent Devices Sezc Inc. Smart package and monitoring system with indicator and method of making same
DE102019128518A1 (de) * 2019-10-22 2021-04-22 Schreiner Group Gmbh & Co. Kg Elektronische Etikettieranordnung, Verfahren zum Herstellen einer elektronischen Etikettieranordnung und Medikamentenverpackung
EP4000586A1 (fr) 2020-11-24 2022-05-25 go.ecoblister GmbH Récipient pour médicaments, ensemble permettant de former un récipient pour médicaments et procédé de fourniture d'un récipient pour médicaments

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000075039A2 (fr) * 1999-06-02 2000-12-14 Alcan Technology & Management Ltd. Emballage pour comprimes ne presentant pas de danger pour les enfants
CA2525042A1 (fr) * 2003-06-10 2004-12-23 Meadwestvaco Corporation Systeme perfectionne comportant des circuits electroniques
EP1006982B1 (fr) * 1997-02-19 2006-07-19 Cypak AB Detecteur de distribution de medicament
CA2493410A1 (fr) * 2005-01-20 2006-07-20 Intelligent Devices Inc. Processus d'assemblage, de production et d'assurance qualite relatifs a des etiquettes de surveillance de conformite electronique (ecm)
CA2635476A1 (fr) * 2005-12-12 2007-06-21 International Paper Company Interrupteur de maintien integre au conditionnement d'un article

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1006982B1 (fr) * 1997-02-19 2006-07-19 Cypak AB Detecteur de distribution de medicament
WO2000075039A2 (fr) * 1999-06-02 2000-12-14 Alcan Technology & Management Ltd. Emballage pour comprimes ne presentant pas de danger pour les enfants
CA2525042A1 (fr) * 2003-06-10 2004-12-23 Meadwestvaco Corporation Systeme perfectionne comportant des circuits electroniques
CA2493410A1 (fr) * 2005-01-20 2006-07-20 Intelligent Devices Inc. Processus d'assemblage, de production et d'assurance qualite relatifs a des etiquettes de surveillance de conformite electronique (ecm)
CA2635476A1 (fr) * 2005-12-12 2007-06-21 International Paper Company Interrupteur de maintien integre au conditionnement d'un article

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
GRAFIX® PLASTICS: "Cellulose Acetate Cast Acetate Film", PRODUCT DATA SHEET, January 2004 (2004-01-01), Retrieved from the Internet <URL:http://www.grafixplastics.com/downloads/acetate.pdf> [retrieved on 200901] *
GRAFIX® PLASTICS: "Dura-LarTM Oriented Polyester Film", PRODUCT DATA SHEET, October 2001 (2001-10-01), Retrieved from the Internet <URL:http://www.grafixplastics.com/downloads/dura-lar.pdf> [retrieved on 200901] *

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE112011103562T5 (de) 2010-10-27 2013-08-08 Intelligent Devices, Inc. Einwegeinnahmeüberwachungspackung mit abnehmbarer wiederverwendbarer elektronischer Schaltplatte
DE112011103562B4 (de) * 2010-10-27 2017-05-04 Intelligent Devices Sezc Inc. Einwegeinnahmeüberwachungspackung mit abnehmbarer wiederverwendbarer elektronischer Schaltplatte
US10278287B2 (en) 2012-04-25 2019-04-30 Intelligent Devices Sezc Inc. Smart package and monitoring system with indicator and method of making same
DE102019128518A1 (de) * 2019-10-22 2021-04-22 Schreiner Group Gmbh & Co. Kg Elektronische Etikettieranordnung, Verfahren zum Herstellen einer elektronischen Etikettieranordnung und Medikamentenverpackung
EP4000586A1 (fr) 2020-11-24 2022-05-25 go.ecoblister GmbH Récipient pour médicaments, ensemble permettant de former un récipient pour médicaments et procédé de fourniture d'un récipient pour médicaments

Similar Documents

Publication Publication Date Title
JP6278412B2 (ja) インジケータをもつスマートパッケージ及びモニタリングシステム、並びにそれらを製作する方法
JP5241911B2 (ja) カード型包装体
JP5081835B2 (ja) 医薬品及びその類似物のためのパックとパック方法及びパック製造装置
ES2578616T3 (es) Método para la fijación de una tarjeta de información a un artículo envasado en un blíster, una tarjeta de información y un sistema que usa la tarjeta de información
US8973773B2 (en) Seals
EP3564138A1 (fr) Appareil d&#39;emballage de médicaments
KR20050123109A (ko) 어린이의 접근 저지 및 성인의 취급 편의성 카드형블리스터 포장재
KR20120135482A (ko) 경구 의약을 위한 투여방법 및 패키징
KR20130009661A (ko) 용량 단위를 위한 투여 방법 및 패키징
WO2009135283A1 (fr) Élément annexe d’emballage coque
JP4030947B2 (ja) ブリスタ包装機
CA2567546C (fr) Accessoire d&#39;emballage-coque
US20060254949A1 (en) Credit card-shaped drug delivery system
JP4961499B1 (ja) 特定日に服用する１回分の薬剤を収納するための包装体
JP3125906U (ja) 容器用表示ラベル
CN110683092A (zh) 一种药板及其封装方法
US20190321263A1 (en) Medication administration guide
TW552224B (en) Package product for use with vacuum package for a medication capsule and method for making same

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 08748252

Country of ref document: EP

Kind code of ref document: A1

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 08748252

Country of ref document: EP

Kind code of ref document: A1