WO2009119980A3 - 미세소관 형성 저해제로서 유용한 벤조페논 티아졸 유도체 및 이의 제조 방법 - Google Patents

미세소관 형성 저해제로서 유용한 벤조페논 티아졸 유도체 및 이의 제조 방법 Download PDF

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Publication number
WO2009119980A3
WO2009119980A3 PCT/KR2009/001095 KR2009001095W WO2009119980A3 WO 2009119980 A3 WO2009119980 A3 WO 2009119980A3 KR 2009001095 W KR2009001095 W KR 2009001095W WO 2009119980 A3 WO2009119980 A3 WO 2009119980A3
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WO
WIPO (PCT)
Prior art keywords
same
thiazole derivatives
producing
microtubule
derivatives useful
Prior art date
Application number
PCT/KR2009/001095
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English (en)
French (fr)
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WO2009119980A2 (ko
Inventor
최남송
김영훈
이재광
강희룡
최호진
문승기
김수진
박규태
한병훈
김달현
최재훈
이성숙
안순길
이경주
배수열
Original Assignee
주식회사 종근당
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사 종근당 filed Critical 주식회사 종근당
Priority to AU2009229709A priority Critical patent/AU2009229709B2/en
Priority to US12/934,521 priority patent/US8362267B2/en
Priority to MX2010010561A priority patent/MX2010010561A/es
Priority to EP09725663.0A priority patent/EP2272845B1/en
Priority to JP2011501712A priority patent/JP5378499B2/ja
Priority to ES09725663.0T priority patent/ES2536794T3/es
Priority to CA2719243A priority patent/CA2719243C/en
Priority to PL09725663T priority patent/PL2272845T3/pl
Priority to CN200980110763.9A priority patent/CN101981029B/zh
Priority to BRPI0906248A priority patent/BRPI0906248B8/pt
Priority to DK09725663.0T priority patent/DK2272845T3/en
Publication of WO2009119980A2 publication Critical patent/WO2009119980A2/ko
Publication of WO2009119980A3 publication Critical patent/WO2009119980A3/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

본 발명은 화학식 1의 신규 벤조페논 티아졸 유도체, 이의 이성질체, 약제학적으로 허용 가능한 이의 염, 이의 수화물 또는 이의 용매화물, 이를 함유하는 약제학적 조성물, 이의 치료제로서의 용도 및 그 제조 방법에 관한 것이다. 본 발명의 벤조페논 티아졸 유도체는 미세소관 형성의 저해 활성을 가지며, 악성종양의 활성적인 증식세포를 살멸하여 일반적인 증식상태를 치료하는 데 사용될 수 있다. 화학식 1에서 R, R1 및 R2는 발명의 상세한 설명에서 정의된 바와 같다.
PCT/KR2009/001095 2008-03-26 2009-03-05 미세소관 형성 저해제로서 유용한 벤조페논 티아졸 유도체 및 이의 제조 방법 WO2009119980A2 (ko)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AU2009229709A AU2009229709B2 (en) 2008-03-26 2009-03-05 Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
US12/934,521 US8362267B2 (en) 2008-03-26 2009-03-05 Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
MX2010010561A MX2010010561A (es) 2008-03-26 2009-03-05 Derivados tiazol de benzofenona utiles para inhibir la formacion del microtúbulo, y método para producir los mismos.
EP09725663.0A EP2272845B1 (en) 2008-03-26 2009-03-05 Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
JP2011501712A JP5378499B2 (ja) 2008-03-26 2009-03-05 微小管形成阻害剤として有用なベンゾフェノンチアゾール誘導体及びその製造方法
ES09725663.0T ES2536794T3 (es) 2008-03-26 2009-03-05 Derivados de benzofenona tiazol útiles para inhibir la formación de microtúbulos y método de producción de los mismos
CA2719243A CA2719243C (en) 2008-03-26 2009-03-05 Benzophenone thiazole derivatives useful for inhibiting formation of microtubule and method for producing the same
PL09725663T PL2272845T3 (pl) 2008-03-26 2009-03-05 Benzofenonotiazolowe pochodne użyteczne do hamowania tworzenia mikrotubul i sposób ich wytwarzania
CN200980110763.9A CN101981029B (zh) 2008-03-26 2009-03-05 用于抑制微管形成的苯甲酮噻唑衍生物及其制备方法
BRPI0906248A BRPI0906248B8 (pt) 2008-03-26 2009-03-05 composto, composição farmacêutica para inibir a formação de microtúbulos e método para preparar um composto
DK09725663.0T DK2272845T3 (en) 2008-03-26 2009-03-05 Benzophenone Thiazole Derivatives for Inhibiting Microtubule Formation and Method for Preparation thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20080027820 2008-03-26
KR10-2008-0027820 2008-03-26

Publications (2)

Publication Number Publication Date
WO2009119980A2 WO2009119980A2 (ko) 2009-10-01
WO2009119980A3 true WO2009119980A3 (ko) 2009-12-17

Family

ID=41114435

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2009/001095 WO2009119980A2 (ko) 2008-03-26 2009-03-05 미세소관 형성 저해제로서 유용한 벤조페논 티아졸 유도체 및 이의 제조 방법

Country Status (15)

Country Link
US (1) US8362267B2 (ko)
EP (1) EP2272845B1 (ko)
JP (1) JP5378499B2 (ko)
KR (1) KR101069735B1 (ko)
CN (1) CN101981029B (ko)
AU (1) AU2009229709B2 (ko)
BR (1) BRPI0906248B8 (ko)
CA (1) CA2719243C (ko)
DK (1) DK2272845T3 (ko)
ES (1) ES2536794T3 (ko)
HU (1) HUE025268T2 (ko)
MX (1) MX2010010561A (ko)
PL (1) PL2272845T3 (ko)
PT (1) PT2272845E (ko)
WO (1) WO2009119980A2 (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019517506A (ja) * 2016-07-29 2019-06-24 チョン クン ダン ファーマシューティカル コーポレーション 血管破壊剤を含む肝臓癌治療用の組成物
US9980953B2 (en) 2016-09-26 2018-05-29 Chong Kun Dang Pharmaceutical Corp. Combined composition for preventing or treating cancer comprising a benzophenone thiazole derivatives as a VDA and topoisomerase inhibitor
CN107163011B (zh) * 2017-05-27 2019-10-01 上海应用技术大学 3-(3,4,5-三甲氧基苯甲酰)-苯并呋喃类微管蛋白抑制剂及其制备方法和用途
CA3066360C (en) * 2017-07-26 2022-05-17 Chong Kun Dang Pharmaceutical Corp. Combination for preventing or treating cancer comprising a vascular disrupting agent and immune checkpoint inhibitor
KR102216772B1 (ko) 2018-05-18 2021-02-17 주식회사 종근당 혈관차단제 및 탁산 화합물을 포함하는 암 예방 또는 치료용 조성물

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078144A2 (en) * 2003-03-05 2004-09-16 Celgene Corporation Diphenylethylene compounds and uses thereof
WO2005009940A1 (en) * 2003-07-24 2005-02-03 Leo Pharma A/S Novel aminobenzophenone compounds
WO2006063585A1 (en) * 2004-12-13 2006-06-22 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
WO2008038955A1 (en) * 2006-09-27 2008-04-03 Chong Kun Dang Pharmaceutical Corp. Benzophenone derivatives useful for inhibiting formation of microtubule

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004078144A2 (en) * 2003-03-05 2004-09-16 Celgene Corporation Diphenylethylene compounds and uses thereof
WO2005009940A1 (en) * 2003-07-24 2005-02-03 Leo Pharma A/S Novel aminobenzophenone compounds
WO2006063585A1 (en) * 2004-12-13 2006-06-22 Leo Pharma A/S Triazole substituted aminobenzophenone compounds
WO2008038955A1 (en) * 2006-09-27 2008-04-03 Chong Kun Dang Pharmaceutical Corp. Benzophenone derivatives useful for inhibiting formation of microtubule

Also Published As

Publication number Publication date
CN101981029B (zh) 2014-04-02
JP2011515461A (ja) 2011-05-19
CA2719243A1 (en) 2009-10-01
US8362267B2 (en) 2013-01-29
CN101981029A (zh) 2011-02-23
PT2272845E (pt) 2015-06-01
KR20090102639A (ko) 2009-09-30
BRPI0906248B8 (pt) 2021-05-25
AU2009229709A1 (en) 2009-10-01
US20110021582A1 (en) 2011-01-27
AU2009229709B2 (en) 2011-12-08
BRPI0906248A2 (pt) 2016-10-25
WO2009119980A2 (ko) 2009-10-01
CA2719243C (en) 2013-06-25
BRPI0906248B1 (pt) 2020-01-21
EP2272845A4 (en) 2014-01-01
EP2272845B1 (en) 2015-03-04
ES2536794T3 (es) 2015-05-28
DK2272845T3 (en) 2015-05-04
EP2272845A2 (en) 2011-01-12
PL2272845T3 (pl) 2015-08-31
KR101069735B1 (ko) 2011-10-04
JP5378499B2 (ja) 2013-12-25
HUE025268T2 (en) 2016-02-29
MX2010010561A (es) 2010-10-25

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