WO2009086070A2 - Systèmes de mélange de composants de gomme en parallèle et procédés associés - Google Patents
Systèmes de mélange de composants de gomme en parallèle et procédés associés Download PDFInfo
- Publication number
- WO2009086070A2 WO2009086070A2 PCT/US2008/087625 US2008087625W WO2009086070A2 WO 2009086070 A2 WO2009086070 A2 WO 2009086070A2 US 2008087625 W US2008087625 W US 2008087625W WO 2009086070 A2 WO2009086070 A2 WO 2009086070A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mixer
- gum
- ingredients
- mixing
- finished
- Prior art date
Links
- 238000002156 mixing Methods 0.000 title claims abstract description 346
- 238000000034 method Methods 0.000 title claims abstract description 126
- 239000004615 ingredient Substances 0.000 claims abstract description 966
- 230000008569 process Effects 0.000 claims description 95
- 238000011144 upstream manufacturing Methods 0.000 claims description 53
- 238000004519 manufacturing process Methods 0.000 claims description 34
- 239000004594 Masterbatch (MB) Substances 0.000 claims description 30
- 235000015218 chewing gum Nutrition 0.000 claims description 10
- 229940112822 chewing gum Drugs 0.000 claims description 9
- 229920000591 gum Polymers 0.000 description 1066
- 239000002585 base Substances 0.000 description 373
- 239000000203 mixture Substances 0.000 description 137
- 229920001971 elastomer Polymers 0.000 description 124
- 239000000806 elastomer Substances 0.000 description 123
- 239000000796 flavoring agent Substances 0.000 description 122
- 235000019634 flavors Nutrition 0.000 description 108
- 235000003599 food sweetener Nutrition 0.000 description 91
- 239000003765 sweetening agent Substances 0.000 description 91
- -1 softeners Substances 0.000 description 73
- 239000000945 filler Substances 0.000 description 64
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 55
- 239000004014 plasticizer Substances 0.000 description 54
- 239000001993 wax Substances 0.000 description 39
- 239000003086 colorant Substances 0.000 description 32
- 239000000463 material Substances 0.000 description 32
- 238000003860 storage Methods 0.000 description 30
- 238000012545 processing Methods 0.000 description 27
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 26
- 239000002253 acid Substances 0.000 description 26
- 239000003795 chemical substances by application Substances 0.000 description 24
- 239000000047 product Substances 0.000 description 24
- 235000011187 glycerol Nutrition 0.000 description 23
- 229960005150 glycerol Drugs 0.000 description 23
- 239000003921 oil Substances 0.000 description 23
- 235000019198 oils Nutrition 0.000 description 23
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 21
- 235000013615 non-nutritive sweetener Nutrition 0.000 description 21
- 241000196324 Embryophyta Species 0.000 description 19
- 239000008123 high-intensity sweetener Substances 0.000 description 19
- 238000013329 compounding Methods 0.000 description 18
- 239000003925 fat Substances 0.000 description 18
- 235000019197 fats Nutrition 0.000 description 18
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 239000000284 extract Substances 0.000 description 17
- 239000012530 fluid Substances 0.000 description 17
- 239000007788 liquid Substances 0.000 description 17
- 238000001816 cooling Methods 0.000 description 16
- 230000006870 function Effects 0.000 description 16
- 235000010449 maltitol Nutrition 0.000 description 16
- 239000000600 sorbitol Substances 0.000 description 16
- 229960002920 sorbitol Drugs 0.000 description 16
- ZENOXNGFMSCLLL-UHFFFAOYSA-N vanillyl alcohol Chemical compound COC1=CC(CO)=CC=C1O ZENOXNGFMSCLLL-UHFFFAOYSA-N 0.000 description 16
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 15
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 15
- 235000013355 food flavoring agent Nutrition 0.000 description 15
- 239000000845 maltitol Substances 0.000 description 15
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 15
- 235000010356 sorbitol Nutrition 0.000 description 15
- 239000003814 drug Substances 0.000 description 14
- 229940035436 maltitol Drugs 0.000 description 14
- 210000000214 mouth Anatomy 0.000 description 14
- 235000002639 sodium chloride Nutrition 0.000 description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 13
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 13
- 150000007513 acids Chemical class 0.000 description 13
- 150000001875 compounds Chemical class 0.000 description 13
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 12
- 239000011449 brick Substances 0.000 description 12
- 235000010216 calcium carbonate Nutrition 0.000 description 12
- 229940041616 menthol Drugs 0.000 description 12
- 239000006188 syrup Substances 0.000 description 12
- 235000020357 syrup Nutrition 0.000 description 12
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 11
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 description 11
- 229910000019 calcium carbonate Inorganic materials 0.000 description 11
- 229940079593 drug Drugs 0.000 description 11
- 239000003995 emulsifying agent Substances 0.000 description 11
- 229920005862 polyol Polymers 0.000 description 11
- 150000003077 polyols Chemical class 0.000 description 11
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 description 11
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 10
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 description 10
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 10
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 10
- 239000003963 antioxidant agent Substances 0.000 description 10
- 235000006708 antioxidants Nutrition 0.000 description 10
- 239000004067 bulking agent Substances 0.000 description 10
- 239000001506 calcium phosphate Substances 0.000 description 10
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 10
- 238000002844 melting Methods 0.000 description 10
- 230000008018 melting Effects 0.000 description 10
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 10
- 235000018102 proteins Nutrition 0.000 description 10
- 102000004169 proteins and genes Human genes 0.000 description 10
- 108090000623 proteins and genes Proteins 0.000 description 10
- 235000019640 taste Nutrition 0.000 description 10
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 10
- 235000010447 xylitol Nutrition 0.000 description 10
- 239000000811 xylitol Substances 0.000 description 10
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 10
- 229960002675 xylitol Drugs 0.000 description 10
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 9
- 229940124584 antitussives Drugs 0.000 description 9
- 235000010445 lecithin Nutrition 0.000 description 9
- 239000000787 lecithin Substances 0.000 description 9
- 229940067606 lecithin Drugs 0.000 description 9
- 239000008188 pellet Substances 0.000 description 9
- 230000008447 perception Effects 0.000 description 9
- 229920000642 polymer Polymers 0.000 description 9
- 239000011347 resin Substances 0.000 description 9
- 229920005989 resin Polymers 0.000 description 9
- 150000003839 salts Chemical class 0.000 description 9
- 229940088594 vitamin Drugs 0.000 description 9
- 229930003231 vitamin Natural products 0.000 description 9
- 235000013343 vitamin Nutrition 0.000 description 9
- 239000011782 vitamin Substances 0.000 description 9
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 8
- 239000004386 Erythritol Substances 0.000 description 8
- UNXHWFMMPAWVPI-UHFFFAOYSA-N Erythritol Natural products OCC(O)C(O)CO UNXHWFMMPAWVPI-UHFFFAOYSA-N 0.000 description 8
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 8
- 235000009499 Vanilla fragrans Nutrition 0.000 description 8
- 244000263375 Vanilla tahitensis Species 0.000 description 8
- 235000012036 Vanilla tahitensis Nutrition 0.000 description 8
- 235000010358 acesulfame potassium Nutrition 0.000 description 8
- 239000000619 acesulfame-K Substances 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- WNLRTRBMVRJNCN-UHFFFAOYSA-N adipic acid Chemical compound OC(=O)CCCCC(O)=O WNLRTRBMVRJNCN-UHFFFAOYSA-N 0.000 description 8
- 239000003434 antitussive agent Substances 0.000 description 8
- 230000009286 beneficial effect Effects 0.000 description 8
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 description 8
- UNXHWFMMPAWVPI-ZXZARUISSA-N erythritol Chemical compound OC[C@H](O)[C@H](O)CO UNXHWFMMPAWVPI-ZXZARUISSA-N 0.000 description 8
- 235000019414 erythritol Nutrition 0.000 description 8
- 229940009714 erythritol Drugs 0.000 description 8
- 238000002360 preparation method Methods 0.000 description 8
- 229960004793 sucrose Drugs 0.000 description 8
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 7
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 7
- 235000019789 appetite Nutrition 0.000 description 7
- 230000036528 appetite Effects 0.000 description 7
- 239000008376 breath freshener Substances 0.000 description 7
- 235000015165 citric acid Nutrition 0.000 description 7
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 239000002826 coolant Substances 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 description 7
- 235000010755 mineral Nutrition 0.000 description 7
- 239000011707 mineral Substances 0.000 description 7
- 239000011734 sodium Substances 0.000 description 7
- 229910052708 sodium Inorganic materials 0.000 description 7
- 229940083542 sodium Drugs 0.000 description 7
- 235000015424 sodium Nutrition 0.000 description 7
- 239000005720 sucrose Substances 0.000 description 7
- 239000004094 surface-active agent Substances 0.000 description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 description 7
- 239000008158 vegetable oil Substances 0.000 description 7
- 239000002023 wood Substances 0.000 description 7
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 6
- XPCTZQVDEJYUGT-UHFFFAOYSA-N 3-hydroxy-2-methyl-4-pyrone Chemical compound CC=1OC=CC(=O)C=1O XPCTZQVDEJYUGT-UHFFFAOYSA-N 0.000 description 6
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 6
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 6
- 229930006000 Sucrose Natural products 0.000 description 6
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 6
- 240000008042 Zea mays Species 0.000 description 6
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 6
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 6
- 239000000730 antalgic agent Substances 0.000 description 6
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 6
- 229920005549 butyl rubber Polymers 0.000 description 6
- 230000015556 catabolic process Effects 0.000 description 6
- 229930002875 chlorophyll Natural products 0.000 description 6
- 235000019804 chlorophyll Nutrition 0.000 description 6
- 229940106705 chlorophyll Drugs 0.000 description 6
- ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 6
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 description 6
- 235000005822 corn Nutrition 0.000 description 6
- 238000006731 degradation reaction Methods 0.000 description 6
- 239000000975 dye Substances 0.000 description 6
- 235000013399 edible fruits Nutrition 0.000 description 6
- 239000003172 expectorant agent Substances 0.000 description 6
- WTEVQBCEXWBHNA-JXMROGBWSA-N geranial Chemical compound CC(C)=CCC\C(C)=C\C=O WTEVQBCEXWBHNA-JXMROGBWSA-N 0.000 description 6
- 238000010438 heat treatment Methods 0.000 description 6
- 235000010439 isomalt Nutrition 0.000 description 6
- 239000000905 isomalt Substances 0.000 description 6
- HPIGCVXMBGOWTF-UHFFFAOYSA-N isomaltol Natural products CC(=O)C=1OC=CC=1O HPIGCVXMBGOWTF-UHFFFAOYSA-N 0.000 description 6
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 6
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 6
- 239000011785 micronutrient Substances 0.000 description 6
- 235000013369 micronutrients Nutrition 0.000 description 6
- 230000035807 sensation Effects 0.000 description 6
- 235000019615 sensations Nutrition 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 239000002904 solvent Substances 0.000 description 6
- 235000019408 sucralose Nutrition 0.000 description 6
- 235000002906 tartaric acid Nutrition 0.000 description 6
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 6
- MWOOGOJBHIARFG-UHFFFAOYSA-N vanillin Chemical compound COC1=CC(C=O)=CC=C1O MWOOGOJBHIARFG-UHFFFAOYSA-N 0.000 description 6
- 238000010792 warming Methods 0.000 description 6
- NFLGAXVYCFJBMK-RKDXNWHRSA-N (+)-isomenthone Natural products CC(C)[C@H]1CC[C@@H](C)CC1=O NFLGAXVYCFJBMK-RKDXNWHRSA-N 0.000 description 5
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 5
- 241000167854 Bourreria succulenta Species 0.000 description 5
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 5
- 235000005979 Citrus limon Nutrition 0.000 description 5
- 244000131522 Citrus pyriformis Species 0.000 description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 5
- NFLGAXVYCFJBMK-UHFFFAOYSA-N Menthone Chemical compound CC(C)C1CCC(C)CC1=O NFLGAXVYCFJBMK-UHFFFAOYSA-N 0.000 description 5
- 229920002367 Polyisobutene Polymers 0.000 description 5
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 5
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 5
- 239000004376 Sucralose Substances 0.000 description 5
- 244000078534 Vaccinium myrtillus Species 0.000 description 5
- 150000001299 aldehydes Chemical class 0.000 description 5
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 5
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 5
- 229940035676 analgesics Drugs 0.000 description 5
- 229940069428 antacid Drugs 0.000 description 5
- 239000003159 antacid agent Substances 0.000 description 5
- 229940125715 antihistaminic agent Drugs 0.000 description 5
- 239000000739 antihistaminic agent Substances 0.000 description 5
- 235000010323 ascorbic acid Nutrition 0.000 description 5
- 239000011668 ascorbic acid Substances 0.000 description 5
- 229960005070 ascorbic acid Drugs 0.000 description 5
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 5
- 235000012677 beetroot red Nutrition 0.000 description 5
- 230000015572 biosynthetic process Effects 0.000 description 5
- 229910000389 calcium phosphate Inorganic materials 0.000 description 5
- 235000010980 cellulose Nutrition 0.000 description 5
- 229920002678 cellulose Polymers 0.000 description 5
- 235000019693 cherries Nutrition 0.000 description 5
- 235000017803 cinnamon Nutrition 0.000 description 5
- 235000020971 citrus fruits Nutrition 0.000 description 5
- 235000009508 confectionery Nutrition 0.000 description 5
- 235000015872 dietary supplement Nutrition 0.000 description 5
- 150000002148 esters Chemical class 0.000 description 5
- 239000001530 fumaric acid Substances 0.000 description 5
- 235000011087 fumaric acid Nutrition 0.000 description 5
- 235000003869 genetically modified organism Nutrition 0.000 description 5
- 229960001031 glucose Drugs 0.000 description 5
- 239000001087 glyceryl triacetate Substances 0.000 description 5
- 235000013773 glyceryl triacetate Nutrition 0.000 description 5
- 235000014655 lactic acid Nutrition 0.000 description 5
- 239000004310 lactic acid Substances 0.000 description 5
- 239000001630 malic acid Substances 0.000 description 5
- 235000011090 malic acid Nutrition 0.000 description 5
- 229930007503 menthone Natural products 0.000 description 5
- HLIAVLHNDJUHFG-HOTGVXAUSA-N neotame Chemical compound CC(C)(C)CCN[C@@H](CC(O)=O)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 HLIAVLHNDJUHFG-HOTGVXAUSA-N 0.000 description 5
- 239000008601 oleoresin Substances 0.000 description 5
- 238000004806 packaging method and process Methods 0.000 description 5
- 208000035824 paresthesia Diseases 0.000 description 5
- 239000011118 polyvinyl acetate Substances 0.000 description 5
- 229920002689 polyvinyl acetate Polymers 0.000 description 5
- 230000001953 sensory effect Effects 0.000 description 5
- 239000000021 stimulant Substances 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 5
- 239000011975 tartaric acid Substances 0.000 description 5
- 235000019587 texture Nutrition 0.000 description 5
- 239000004408 titanium dioxide Substances 0.000 description 5
- 235000010215 titanium dioxide Nutrition 0.000 description 5
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 5
- 229960002622 triacetin Drugs 0.000 description 5
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 4
- KWGRBVOPPLSCSI-WPRPVWTQSA-N (-)-ephedrine Chemical compound CN[C@@H](C)[C@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WPRPVWTQSA-N 0.000 description 4
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 4
- KJPRLNWUNMBNBZ-QPJJXVBHSA-N (E)-cinnamaldehyde Chemical compound O=C\C=C\C1=CC=CC=C1 KJPRLNWUNMBNBZ-QPJJXVBHSA-N 0.000 description 4
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 4
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 description 4
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 description 4
- 101800000112 Acidic peptide Proteins 0.000 description 4
- 108010011485 Aspartame Proteins 0.000 description 4
- 108010076119 Caseins Proteins 0.000 description 4
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 4
- VUNOFAIHSALQQH-UHFFFAOYSA-N Ethyl menthane carboxamide Chemical compound CCNC(=O)C1CC(C)CCC1C(C)C VUNOFAIHSALQQH-UHFFFAOYSA-N 0.000 description 4
- 102100028313 Fibrinogen beta chain Human genes 0.000 description 4
- 108010010803 Gelatin Proteins 0.000 description 4
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 4
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 4
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 4
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 description 4
- 229920000161 Locust bean gum Polymers 0.000 description 4
- ZPXSCAKFGYXMGA-UHFFFAOYSA-N Mazindol Chemical compound N12CCN=C2C2=CC=CC=C2C1(O)C1=CC=C(Cl)C=C1 ZPXSCAKFGYXMGA-UHFFFAOYSA-N 0.000 description 4
- 235000014749 Mentha crispa Nutrition 0.000 description 4
- 244000078639 Mentha spicata Species 0.000 description 4
- RWAXQWRDVUOOGG-UHFFFAOYSA-N N,2,3-Trimethyl-2-(1-methylethyl)butanamide Chemical compound CNC(=O)C(C)(C(C)C)C(C)C RWAXQWRDVUOOGG-UHFFFAOYSA-N 0.000 description 4
- 239000004384 Neotame Substances 0.000 description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 4
- 239000004698 Polyethylene Substances 0.000 description 4
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 4
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 4
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 4
- 235000011941 Tilia x europaea Nutrition 0.000 description 4
- 240000006909 Tilia x europaea Species 0.000 description 4
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 4
- 239000001361 adipic acid Substances 0.000 description 4
- 235000011037 adipic acid Nutrition 0.000 description 4
- 239000012675 alcoholic extract Substances 0.000 description 4
- 235000010210 aluminium Nutrition 0.000 description 4
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 4
- 230000000954 anitussive effect Effects 0.000 description 4
- 235000010357 aspartame Nutrition 0.000 description 4
- 239000000605 aspartame Substances 0.000 description 4
- 229960003438 aspartame Drugs 0.000 description 4
- 230000008901 benefit Effects 0.000 description 4
- BLFLLBZGZJTVJG-UHFFFAOYSA-N benzocaine Chemical compound CCOC(=O)C1=CC=C(N)C=C1 BLFLLBZGZJTVJG-UHFFFAOYSA-N 0.000 description 4
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 4
- 229960001948 caffeine Drugs 0.000 description 4
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 description 4
- 235000011010 calcium phosphates Nutrition 0.000 description 4
- YKPUWZUDDOIDPM-SOFGYWHQSA-N capsaicin Chemical compound COC1=CC(CNC(=O)CCCC\C=C\C(C)C)=CC=C1O YKPUWZUDDOIDPM-SOFGYWHQSA-N 0.000 description 4
- 239000005018 casein Substances 0.000 description 4
- BECPQYXYKAMYBN-UHFFFAOYSA-N casein, tech. Chemical compound NCCCCC(C(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(CC(C)C)N=C(O)C(CCC(O)=O)N=C(O)C(CC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(C(C)O)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=N)N=C(O)C(CCC(O)=O)N=C(O)C(CCC(O)=O)N=C(O)C(COP(O)(O)=O)N=C(O)C(CCC(O)=N)N=C(O)C(N)CC1=CC=CC=C1 BECPQYXYKAMYBN-UHFFFAOYSA-N 0.000 description 4
- 235000021240 caseins Nutrition 0.000 description 4
- 230000001055 chewing effect Effects 0.000 description 4
- KJPRLNWUNMBNBZ-UHFFFAOYSA-N cinnamic aldehyde Natural products O=CC=CC1=CC=CC=C1 KJPRLNWUNMBNBZ-UHFFFAOYSA-N 0.000 description 4
- 229940117916 cinnamic aldehyde Drugs 0.000 description 4
- 229910052802 copper Inorganic materials 0.000 description 4
- 239000010949 copper Substances 0.000 description 4
- 229940108928 copper Drugs 0.000 description 4
- 239000006071 cream Substances 0.000 description 4
- KSMVZQYAVGTKIV-UHFFFAOYSA-N decanal Chemical compound CCCCCCCCCC=O KSMVZQYAVGTKIV-UHFFFAOYSA-N 0.000 description 4
- 235000014113 dietary fatty acids Nutrition 0.000 description 4
- ICFXZZFWRWNZMA-UHFFFAOYSA-N diethylpropion hydrochloride Chemical compound [Cl-].CC[NH+](CC)C(C)C(=O)C1=CC=CC=C1 ICFXZZFWRWNZMA-UHFFFAOYSA-N 0.000 description 4
- 239000000686 essence Substances 0.000 description 4
- CBOQJANXLMLOSS-UHFFFAOYSA-N ethyl vanillin Chemical compound CCOC1=CC(C=O)=CC=C1O CBOQJANXLMLOSS-UHFFFAOYSA-N 0.000 description 4
- 229930195729 fatty acid Natural products 0.000 description 4
- 239000000194 fatty acid Substances 0.000 description 4
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 229940014259 gelatin Drugs 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 description 4
- 239000004571 lime Substances 0.000 description 4
- AGBQKNBQESQNJD-UHFFFAOYSA-N lipoic acid Chemical compound OC(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-N 0.000 description 4
- 235000010420 locust bean gum Nutrition 0.000 description 4
- 239000001656 lutein Substances 0.000 description 4
- 235000012680 lutein Nutrition 0.000 description 4
- KBPHJBAIARWVSC-RGZFRNHPSA-N lutein Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C KBPHJBAIARWVSC-RGZFRNHPSA-N 0.000 description 4
- 238000007726 management method Methods 0.000 description 4
- 239000000594 mannitol Substances 0.000 description 4
- 229960001855 mannitol Drugs 0.000 description 4
- 235000013336 milk Nutrition 0.000 description 4
- 239000008267 milk Substances 0.000 description 4
- 210000004080 milk Anatomy 0.000 description 4
- 235000019412 neotame Nutrition 0.000 description 4
- 108010070257 neotame Proteins 0.000 description 4
- CFJYNSNXFXLKNS-UHFFFAOYSA-N p-menthane Chemical compound CC(C)C1CCC(C)CC1 CFJYNSNXFXLKNS-UHFFFAOYSA-N 0.000 description 4
- 235000011007 phosphoric acid Nutrition 0.000 description 4
- 229920000573 polyethylene Polymers 0.000 description 4
- 239000011591 potassium Substances 0.000 description 4
- 229910052700 potassium Inorganic materials 0.000 description 4
- 229960003975 potassium Drugs 0.000 description 4
- 235000007686 potassium Nutrition 0.000 description 4
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 4
- 239000003755 preservative agent Substances 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- SQGYOTSLMSWVJD-UHFFFAOYSA-N silver(1+) nitrate Chemical compound [Ag+].[O-]N(=O)=O SQGYOTSLMSWVJD-UHFFFAOYSA-N 0.000 description 4
- PUZPDOWCWNUUKD-UHFFFAOYSA-M sodium fluoride Chemical compound [F-].[Na+] PUZPDOWCWNUUKD-UHFFFAOYSA-M 0.000 description 4
- BXOCHUWSGYYSFW-HVWOQQCMSA-N spilanthol Chemical compound C\C=C\C=C/CC\C=C\C(=O)NCC(C)C BXOCHUWSGYYSFW-HVWOQQCMSA-N 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- 235000000346 sugar Nutrition 0.000 description 4
- KBPHJBAIARWVSC-XQIHNALSSA-N trans-lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C KBPHJBAIARWVSC-XQIHNALSSA-N 0.000 description 4
- 235000012141 vanillin Nutrition 0.000 description 4
- FGQOOHJZONJGDT-UHFFFAOYSA-N vanillin Natural products COC1=CC(O)=CC(C=O)=C1 FGQOOHJZONJGDT-UHFFFAOYSA-N 0.000 description 4
- 239000000341 volatile oil Substances 0.000 description 4
- 229910052725 zinc Inorganic materials 0.000 description 4
- 239000011701 zinc Substances 0.000 description 4
- GRWFGVWFFZKLTI-UHFFFAOYSA-N α-pinene Chemical compound CC1=CCC2C(C)(C)C1C2 GRWFGVWFFZKLTI-UHFFFAOYSA-N 0.000 description 4
- RMLYXMMBIZLGAQ-UHFFFAOYSA-N (-)-monatin Natural products C1=CC=C2C(CC(O)(CC(N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-UHFFFAOYSA-N 0.000 description 3
- YGFGZTXGYTUXBA-UHFFFAOYSA-N (±)-2,6-dimethyl-5-heptenal Chemical compound O=CC(C)CCC=C(C)C YGFGZTXGYTUXBA-UHFFFAOYSA-N 0.000 description 3
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 description 3
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 3
- SPCKHVPPRJWQRZ-UHFFFAOYSA-N 2-benzhydryloxy-n,n-dimethylethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 SPCKHVPPRJWQRZ-UHFFFAOYSA-N 0.000 description 3
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 3
- 244000145321 Acmella oleracea Species 0.000 description 3
- 244000144725 Amygdalus communis Species 0.000 description 3
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- WTEVQBCEXWBHNA-UHFFFAOYSA-N Citral Natural products CC(C)=CCCC(C)=CC=O WTEVQBCEXWBHNA-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 3
- RGHNJXZEOKUKBD-SQOUGZDYSA-N D-gluconic acid Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(O)=O RGHNJXZEOKUKBD-SQOUGZDYSA-N 0.000 description 3
- RGHNJXZEOKUKBD-UHFFFAOYSA-N D-gluconic acid Natural products OCC(O)C(O)C(O)C(O)C(O)=O RGHNJXZEOKUKBD-UHFFFAOYSA-N 0.000 description 3
- 240000002943 Elettaria cardamomum Species 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- YIKYNHJUKRTCJL-UHFFFAOYSA-N Ethyl maltol Chemical compound CCC=1OC=CC(=O)C=1O YIKYNHJUKRTCJL-UHFFFAOYSA-N 0.000 description 3
- 240000004670 Glycyrrhiza echinata Species 0.000 description 3
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 3
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 3
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 3
- 229920000084 Gum arabic Polymers 0.000 description 3
- 229940122957 Histamine H2 receptor antagonist Drugs 0.000 description 3
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical compound CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 3
- MKXZASYAUGDDCJ-SZMVWBNQSA-N LSM-2525 Chemical compound C1CCC[C@H]2[C@@]3([H])N(C)CC[C@]21C1=CC(OC)=CC=C1C3 MKXZASYAUGDDCJ-SZMVWBNQSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- HYMLWHLQFGRFIY-UHFFFAOYSA-N Maltol Natural products CC1OC=CC(=O)C1=O HYMLWHLQFGRFIY-UHFFFAOYSA-N 0.000 description 3
- 229930195725 Mannitol Natural products 0.000 description 3
- 235000016278 Mentha canadensis Nutrition 0.000 description 3
- 244000245214 Mentha canadensis Species 0.000 description 3
- 244000246386 Mentha pulegium Species 0.000 description 3
- 235000016257 Mentha pulegium Nutrition 0.000 description 3
- 235000004357 Mentha x piperita Nutrition 0.000 description 3
- 235000009421 Myristica fragrans Nutrition 0.000 description 3
- 240000000111 Saccharum officinarum Species 0.000 description 3
- 235000007201 Saccharum officinarum Nutrition 0.000 description 3
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical class [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 3
- 235000021536 Sugar beet Nutrition 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- AXMVYSVVTMKQSL-UHFFFAOYSA-N UNPD142122 Natural products OC1=CC=C(C=CC=O)C=C1O AXMVYSVVTMKQSL-UHFFFAOYSA-N 0.000 description 3
- 235000017537 Vaccinium myrtillus Nutrition 0.000 description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 3
- 229930003427 Vitamin E Natural products 0.000 description 3
- 235000009754 Vitis X bourquina Nutrition 0.000 description 3
- 235000012333 Vitis X labruscana Nutrition 0.000 description 3
- 240000006365 Vitis vinifera Species 0.000 description 3
- 235000014787 Vitis vinifera Nutrition 0.000 description 3
- 244000195452 Wasabia japonica Species 0.000 description 3
- 235000000760 Wasabia japonica Nutrition 0.000 description 3
- 235000010489 acacia gum Nutrition 0.000 description 3
- 239000000205 acacia gum Substances 0.000 description 3
- 235000011054 acetic acid Nutrition 0.000 description 3
- 230000002378 acidificating effect Effects 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 235000010443 alginic acid Nutrition 0.000 description 3
- 229920000615 alginic acid Polymers 0.000 description 3
- 229910052783 alkali metal Inorganic materials 0.000 description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 3
- 229910052782 aluminium Inorganic materials 0.000 description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 3
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000001670 anatto Substances 0.000 description 3
- 229940035674 anesthetics Drugs 0.000 description 3
- 235000012665 annatto Nutrition 0.000 description 3
- 235000010208 anthocyanin Nutrition 0.000 description 3
- 239000004410 anthocyanin Substances 0.000 description 3
- 239000003242 anti bacterial agent Substances 0.000 description 3
- 230000001387 anti-histamine Effects 0.000 description 3
- 239000002260 anti-inflammatory agent Substances 0.000 description 3
- 239000002249 anxiolytic agent Substances 0.000 description 3
- 229960005261 aspartic acid Drugs 0.000 description 3
- 235000012733 azorubine Nutrition 0.000 description 3
- 239000001654 beetroot red Substances 0.000 description 3
- 235000012709 brilliant black BN Nutrition 0.000 description 3
- 235000014121 butter Nutrition 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 235000001465 calcium Nutrition 0.000 description 3
- 150000001720 carbohydrates Chemical class 0.000 description 3
- 235000005300 cardamomo Nutrition 0.000 description 3
- 235000012730 carminic acid Nutrition 0.000 description 3
- 239000001913 cellulose Substances 0.000 description 3
- 235000013351 cheese Nutrition 0.000 description 3
- 229960004126 codeine Drugs 0.000 description 3
- 230000003750 conditioning effect Effects 0.000 description 3
- PNZXMIKHJXIPEK-UHFFFAOYSA-N cyclohexanecarboxamide Chemical class NC(=O)C1CCCCC1 PNZXMIKHJXIPEK-UHFFFAOYSA-N 0.000 description 3
- KWGRBVOPPLSCSI-UHFFFAOYSA-N d-ephedrine Natural products CNC(C)C(O)C1=CC=CC=C1 KWGRBVOPPLSCSI-UHFFFAOYSA-N 0.000 description 3
- 229960001985 dextromethorphan Drugs 0.000 description 3
- 239000008121 dextrose Substances 0.000 description 3
- 150000002016 disaccharides Chemical class 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 235000019441 ethanol Nutrition 0.000 description 3
- 229940093503 ethyl maltol Drugs 0.000 description 3
- 230000003419 expectorant effect Effects 0.000 description 3
- 229940066493 expectorants Drugs 0.000 description 3
- 235000019253 formic acid Nutrition 0.000 description 3
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
- 239000003193 general anesthetic agent Substances 0.000 description 3
- 229950006191 gluconic acid Drugs 0.000 description 3
- 229960002449 glycine Drugs 0.000 description 3
- WDPIZEKLJKBSOZ-UHFFFAOYSA-M green s Chemical compound [Na+].C1=CC(N(C)C)=CC=C1C(C=1C2=CC=C(C=C2C=C(C=1O)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](C)C)C=C1 WDPIZEKLJKBSOZ-UHFFFAOYSA-M 0.000 description 3
- 235000019668 heartiness Nutrition 0.000 description 3
- 235000001050 hortel pimenta Nutrition 0.000 description 3
- 239000000416 hydrocolloid Substances 0.000 description 3
- 239000010514 hydrogenated cottonseed oil Substances 0.000 description 3
- 229960001680 ibuprofen Drugs 0.000 description 3
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 3
- 229940010454 licorice Drugs 0.000 description 3
- 235000010187 litholrubine BK Nutrition 0.000 description 3
- 239000004335 litholrubine BK Substances 0.000 description 3
- 239000000711 locust bean gum Substances 0.000 description 3
- 229960005375 lutein Drugs 0.000 description 3
- ORAKUVXRZWMARG-WZLJTJAWSA-N lutein Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=CC(O)CC2(C)C)C ORAKUVXRZWMARG-WZLJTJAWSA-N 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 235000001055 magnesium Nutrition 0.000 description 3
- 229940043353 maltol Drugs 0.000 description 3
- 235000010355 mannitol Nutrition 0.000 description 3
- 239000001525 mentha piperita l. herb oil Substances 0.000 description 3
- 229920000609 methyl cellulose Polymers 0.000 description 3
- 235000010981 methylcellulose Nutrition 0.000 description 3
- 239000001923 methylcellulose Substances 0.000 description 3
- 239000008368 mint flavor Substances 0.000 description 3
- 230000000510 mucolytic effect Effects 0.000 description 3
- 229940066491 mucolytics Drugs 0.000 description 3
- 235000006408 oxalic acid Nutrition 0.000 description 3
- 229930004008 p-menthane Natural products 0.000 description 3
- 235000012658 paprika extract Nutrition 0.000 description 3
- 239000012188 paraffin wax Substances 0.000 description 3
- 235000010987 pectin Nutrition 0.000 description 3
- 239000001814 pectin Substances 0.000 description 3
- 229920001277 pectin Polymers 0.000 description 3
- 235000019477 peppermint oil Nutrition 0.000 description 3
- 239000012169 petroleum derived wax Substances 0.000 description 3
- 235000019381 petroleum wax Nutrition 0.000 description 3
- NCAIGTHBQTXTLR-UHFFFAOYSA-N phentermine hydrochloride Chemical compound [Cl-].CC(C)([NH3+])CC1=CC=CC=C1 NCAIGTHBQTXTLR-UHFFFAOYSA-N 0.000 description 3
- 235000017807 phytochemicals Nutrition 0.000 description 3
- SATCULPHIDQDRE-UHFFFAOYSA-N piperonal Chemical compound O=CC1=CC=C2OCOC2=C1 SATCULPHIDQDRE-UHFFFAOYSA-N 0.000 description 3
- 229930000223 plant secondary metabolite Natural products 0.000 description 3
- 239000011698 potassium fluoride Substances 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- 230000002035 prolonged effect Effects 0.000 description 3
- 230000003134 recirculating effect Effects 0.000 description 3
- 239000011780 sodium chloride Substances 0.000 description 3
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 3
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- ANOBYBYXJXCGBS-UHFFFAOYSA-L stannous fluoride Chemical compound F[Sn]F ANOBYBYXJXCGBS-UHFFFAOYSA-L 0.000 description 3
- 229960002799 stannous fluoride Drugs 0.000 description 3
- 229920003048 styrene butadiene rubber Polymers 0.000 description 3
- 150000005846 sugar alcohols Chemical class 0.000 description 3
- 239000000454 talc Substances 0.000 description 3
- 229910052623 talc Inorganic materials 0.000 description 3
- 235000012222 talc Nutrition 0.000 description 3
- 239000003760 tallow Substances 0.000 description 3
- 235000013311 vegetables Nutrition 0.000 description 3
- 235000019155 vitamin A Nutrition 0.000 description 3
- 239000011719 vitamin A Substances 0.000 description 3
- 239000011709 vitamin E Substances 0.000 description 3
- 235000019165 vitamin E Nutrition 0.000 description 3
- 229940046009 vitamin E Drugs 0.000 description 3
- 229940045997 vitamin a Drugs 0.000 description 3
- FJHBOVDFOQMZRV-XQIHNALSSA-N xanthophyll Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C=C(C)C(O)CC2(C)C FJHBOVDFOQMZRV-XQIHNALSSA-N 0.000 description 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 2
- XMGQYMWWDOXHJM-JTQLQIEISA-N (+)-α-limonene Chemical compound CC(=C)[C@@H]1CCC(C)=CC1 XMGQYMWWDOXHJM-JTQLQIEISA-N 0.000 description 2
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 description 2
- XHXUANMFYXWVNG-ADEWGFFLSA-N (-)-Menthyl acetate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(C)=O XHXUANMFYXWVNG-ADEWGFFLSA-N 0.000 description 2
- VEPOHXYIFQMVHW-PVJVQHJQSA-N (2r,3r)-2,3-dihydroxybutanedioic acid;(2s,3s)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.O1CCN(C)[C@@H](C)[C@@H]1C1=CC=CC=C1 VEPOHXYIFQMVHW-PVJVQHJQSA-N 0.000 description 2
- RMLYXMMBIZLGAQ-HZMBPMFUSA-N (2s,4s)-4-amino-2-hydroxy-2-(1h-indol-3-ylmethyl)pentanedioic acid Chemical compound C1=CC=C2C(C[C@](O)(C[C@H](N)C(O)=O)C(O)=O)=CNC2=C1 RMLYXMMBIZLGAQ-HZMBPMFUSA-N 0.000 description 2
- DMASLKHVQRHNES-UPOGUZCLSA-N (3R)-beta,beta-caroten-3-ol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C DMASLKHVQRHNES-UPOGUZCLSA-N 0.000 description 2
- YDDUMTOHNYZQPO-UHFFFAOYSA-N 1,3-bis{[(2E)-3-(3,4-dihydroxyphenyl)prop-2-enoyl]oxy}-4,5-dihydroxycyclohexanecarboxylic acid Natural products OC1C(O)CC(C(O)=O)(OC(=O)C=CC=2C=C(O)C(O)=CC=2)CC1OC(=O)C=CC1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-UHFFFAOYSA-N 0.000 description 2
- IGOUMBTVEMUDSU-UHFFFAOYSA-N 1-(1-carboxyethyl)-6-(hydroxymethyl)pyridin-1-ium-3-olate Chemical compound OC(=O)C(C)[N+]1=CC([O-])=CC=C1CO IGOUMBTVEMUDSU-UHFFFAOYSA-N 0.000 description 2
- DURPTKYDGMDSBL-UHFFFAOYSA-N 1-butoxybutane Chemical compound CCCCOCCCC DURPTKYDGMDSBL-UHFFFAOYSA-N 0.000 description 2
- GRWFGVWFFZKLTI-IUCAKERBSA-N 1S,5S-(-)-alpha-Pinene Natural products CC1=CC[C@@H]2C(C)(C)[C@H]1C2 GRWFGVWFFZKLTI-IUCAKERBSA-N 0.000 description 2
- FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 2
- SZNYYWIUQFZLLT-UHFFFAOYSA-N 2-methyl-1-(2-methylpropoxy)propane Chemical compound CC(C)COCC(C)C SZNYYWIUQFZLLT-UHFFFAOYSA-N 0.000 description 2
- KPGXRSRHYNQIFN-UHFFFAOYSA-N 2-oxoglutaric acid Chemical compound OC(=O)CCC(=O)C(O)=O KPGXRSRHYNQIFN-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- INAXVXBDKKUCGI-UHFFFAOYSA-N 4-hydroxy-2,5-dimethylfuran-3-one Chemical compound CC1OC(C)=C(O)C1=O INAXVXBDKKUCGI-UHFFFAOYSA-N 0.000 description 2
- 239000005541 ACE inhibitor Substances 0.000 description 2
- 244000215068 Acacia senegal Species 0.000 description 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 description 2
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
- 235000011437 Amygdalus communis Nutrition 0.000 description 2
- 235000011330 Armoracia rusticana Nutrition 0.000 description 2
- 240000003291 Armoracia rusticana Species 0.000 description 2
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 2
- JEBFVOLFMLUKLF-IFPLVEIFSA-N Astaxanthin Natural products CC(=C/C=C/C(=C/C=C/C1=C(C)C(=O)C(O)CC1(C)C)/C)C=CC=C(/C)C=CC=C(/C)C=CC2=C(C)C(=O)C(O)CC2(C)C JEBFVOLFMLUKLF-IFPLVEIFSA-N 0.000 description 2
- 241000193749 Bacillus coagulans Species 0.000 description 2
- 244000063299 Bacillus subtilis Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 241000193417 Brevibacillus laterosporus Species 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- ZTQSAGDEMFDKMZ-UHFFFAOYSA-N Butyraldehyde Chemical compound CCCC=O ZTQSAGDEMFDKMZ-UHFFFAOYSA-N 0.000 description 2
- 235000002566 Capsicum Nutrition 0.000 description 2
- 240000004160 Capsicum annuum Species 0.000 description 2
- 235000008534 Capsicum annuum var annuum Nutrition 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
- BVKZGUZCCUSVTD-UHFFFAOYSA-L Carbonate Chemical compound [O-]C([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-L 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 2
- 244000037364 Cinnamomum aromaticum Species 0.000 description 2
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 description 2
- 235000007716 Citrus aurantium Nutrition 0.000 description 2
- 235000000228 Citrus myrtifolia Nutrition 0.000 description 2
- 240000003791 Citrus myrtifolia Species 0.000 description 2
- 235000016646 Citrus taiwanica Nutrition 0.000 description 2
- 240000000560 Citrus x paradisi Species 0.000 description 2
- 244000241257 Cucumis melo Species 0.000 description 2
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 2
- SITQVDJAXQSXSA-CEZRHVESSA-N Cynarin Natural products O[C@@H]1C[C@@](C[C@H](O)[C@H]1OC(=O)C=Cc2ccc(O)c(O)c2)(OC(=O)C=Cc3cccc(O)c3O)C(=O)O SITQVDJAXQSXSA-CEZRHVESSA-N 0.000 description 2
- YDDUMTOHNYZQPO-RVXRWRFUSA-N Cynarine Chemical compound O([C@@H]1C[C@@](C[C@H]([C@@H]1O)O)(OC(=O)\C=C\C=1C=C(O)C(O)=CC=1)C(O)=O)C(=O)\C=C\C1=CC=C(O)C(O)=C1 YDDUMTOHNYZQPO-RVXRWRFUSA-N 0.000 description 2
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 description 2
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 2
- LCGLNKUTAGEVQW-UHFFFAOYSA-N Dimethyl ether Chemical compound COC LCGLNKUTAGEVQW-UHFFFAOYSA-N 0.000 description 2
- 108010016626 Dipeptides Proteins 0.000 description 2
- 239000001329 FEMA 3811 Substances 0.000 description 2
- 239000004211 Flavoxanthin Substances 0.000 description 2
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 2
- 102000003688 G-Protein-Coupled Receptors Human genes 0.000 description 2
- 108090000045 G-Protein-Coupled Receptors Proteins 0.000 description 2
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 description 2
- 229920000926 Galactomannan Polymers 0.000 description 2
- IAJILQKETJEXLJ-UHFFFAOYSA-N Galacturonsaeure Natural products O=CC(O)C(O)C(O)C(O)C(O)=O IAJILQKETJEXLJ-UHFFFAOYSA-N 0.000 description 2
- 239000005792 Geraniol Substances 0.000 description 2
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 description 2
- 108010068370 Glutens Proteins 0.000 description 2
- HSRJKNPTNIJEKV-UHFFFAOYSA-N Guaifenesin Chemical compound COC1=CC=CC=C1OCC(O)CO HSRJKNPTNIJEKV-UHFFFAOYSA-N 0.000 description 2
- 229920002907 Guar gum Polymers 0.000 description 2
- AKDLSISGGARWFP-UHFFFAOYSA-N Homodihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCCCC(C)C)=CC=C1O AKDLSISGGARWFP-UHFFFAOYSA-N 0.000 description 2
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
- UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 2
- JEVVKJMRZMXFBT-XWDZUXABSA-N Lycophyll Natural products OC/C(=C/CC/C(=C\C=C\C(=C/C=C/C(=C\C=C\C=C(/C=C/C=C(\C=C\C=C(/CC/C=C(/CO)\C)\C)/C)\C)/C)\C)/C)/C JEVVKJMRZMXFBT-XWDZUXABSA-N 0.000 description 2
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 235000011430 Malus pumila Nutrition 0.000 description 2
- 235000015103 Malus silvestris Nutrition 0.000 description 2
- 108010070551 Meat Proteins Proteins 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 208000019695 Migraine disease Diseases 0.000 description 2
- 101710084933 Miraculin Proteins 0.000 description 2
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 2
- ILRKKHJEINIICQ-OOFFSTKBSA-N Monoammonium glycyrrhizinate Chemical compound N.O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O ILRKKHJEINIICQ-OOFFSTKBSA-N 0.000 description 2
- 244000270834 Myristica fragrans Species 0.000 description 2
- 240000009023 Myrrhis odorata Species 0.000 description 2
- 235000007265 Myrrhis odorata Nutrition 0.000 description 2
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 2
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 2
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- ZVKOASAVGLETCT-UOGKPENDSA-N Norbixin Chemical compound OC(=O)/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O ZVKOASAVGLETCT-UOGKPENDSA-N 0.000 description 2
- VQEONGKQWIFHMN-UHFFFAOYSA-N Nordihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCC(C)C)=CC=C1O VQEONGKQWIFHMN-UHFFFAOYSA-N 0.000 description 2
- 244000227633 Ocotea pretiosa Species 0.000 description 2
- 235000004263 Ocotea pretiosa Nutrition 0.000 description 2
- 235000011203 Origanum Nutrition 0.000 description 2
- 240000000783 Origanum majorana Species 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108091005804 Peptidases Proteins 0.000 description 2
- 102000035195 Peptidases Human genes 0.000 description 2
- 235000006990 Pimenta dioica Nutrition 0.000 description 2
- 240000008474 Pimenta dioica Species 0.000 description 2
- 235000012550 Pimpinella anisum Nutrition 0.000 description 2
- DLRVVLDZNNYCBX-UHFFFAOYSA-N Polydextrose Polymers OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(O)O1 DLRVVLDZNNYCBX-UHFFFAOYSA-N 0.000 description 2
- ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
- 244000018633 Prunus armeniaca Species 0.000 description 2
- 235000009827 Prunus armeniaca Nutrition 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 2
- 239000004216 Rhodoxanthin Substances 0.000 description 2
- 244000178231 Rosmarinus officinalis Species 0.000 description 2
- SMTZFNFIKUPEJC-UHFFFAOYSA-N Roxane Chemical compound CC(=O)OCC(=O)NCCCOC1=CC=CC(CN2CCCCC2)=C1 SMTZFNFIKUPEJC-UHFFFAOYSA-N 0.000 description 2
- 235000017848 Rubus fruticosus Nutrition 0.000 description 2
- 240000007651 Rubus glaucus Species 0.000 description 2
- 235000011034 Rubus glaucus Nutrition 0.000 description 2
- 235000009122 Rubus idaeus Nutrition 0.000 description 2
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- UIIMBOGNXHQVGW-DEQYMQKBSA-M Sodium bicarbonate-14C Chemical compound [Na+].O[14C]([O-])=O UIIMBOGNXHQVGW-DEQYMQKBSA-M 0.000 description 2
- 241000204115 Sporolactobacillus inulinus Species 0.000 description 2
- 241001464969 Sporolactobacillus laevolacticus Species 0.000 description 2
- 235000016639 Syzygium aromaticum Nutrition 0.000 description 2
- 244000223014 Syzygium aromaticum Species 0.000 description 2
- JZRWCGZRTZMZEH-UHFFFAOYSA-N Thiamine Natural products CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 2
- 235000007303 Thymus vulgaris Nutrition 0.000 description 2
- 240000002657 Thymus vulgaris Species 0.000 description 2
- 229920001615 Tragacanth Polymers 0.000 description 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 2
- 235000003095 Vaccinium corymbosum Nutrition 0.000 description 2
- 229930003316 Vitamin D Natural products 0.000 description 2
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 2
- 229930003448 Vitamin K Natural products 0.000 description 2
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 description 2
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 2
- CZNLTCTYLMYLHL-UHFFFAOYSA-N [6]-Paradol Chemical compound CCCCCCCC(=O)CCC1=CC=C(O)C(OC)=C1 CZNLTCTYLMYLHL-UHFFFAOYSA-N 0.000 description 2
- 229960004998 acesulfame potassium Drugs 0.000 description 2
- 229960001138 acetylsalicylic acid Drugs 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 229910000288 alkali metal carbonate Inorganic materials 0.000 description 2
- 150000008041 alkali metal carbonates Chemical class 0.000 description 2
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 2
- BXOCHUWSGYYSFW-UHFFFAOYSA-N all-trans spilanthol Natural products CC=CC=CCCC=CC(=O)NCC(C)C BXOCHUWSGYYSFW-UHFFFAOYSA-N 0.000 description 2
- VWXMLZQUDPCJPL-JCFHCUBBSA-N all-trans-Rhodoxanthin Natural products CC(=C/C=C/C(=C/C=C/1C(=CC(=O)CC1(C)C)C)/C)C=CC=CC(=CC=CC(=CC=C2/C(=CC(=O)CC2(C)C)C)C)C VWXMLZQUDPCJPL-JCFHCUBBSA-N 0.000 description 2
- ANVAOWXLWRTKGA-XHGAXZNDSA-N all-trans-alpha-carotene Chemical compound CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1C(C)=CCCC1(C)C ANVAOWXLWRTKGA-XHGAXZNDSA-N 0.000 description 2
- 235000020224 almond Nutrition 0.000 description 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 2
- MVNCAPSFBDBCGF-UHFFFAOYSA-N alpha-pinene Natural products CC1=CCC23C1CC2C3(C)C MVNCAPSFBDBCGF-UHFFFAOYSA-N 0.000 description 2
- 239000004411 aluminium Substances 0.000 description 2
- 150000001408 amides Chemical class 0.000 description 2
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 description 2
- 235000021120 animal protein Nutrition 0.000 description 2
- 229930002877 anthocyanin Natural products 0.000 description 2
- 150000004636 anthocyanins Chemical class 0.000 description 2
- 230000001458 anti-acid effect Effects 0.000 description 2
- 230000001088 anti-asthma Effects 0.000 description 2
- 230000001430 anti-depressive effect Effects 0.000 description 2
- 230000001142 anti-diarrhea Effects 0.000 description 2
- 230000003474 anti-emetic effect Effects 0.000 description 2
- 229940121363 anti-inflammatory agent Drugs 0.000 description 2
- 230000001754 anti-pyretic effect Effects 0.000 description 2
- 230000002421 anti-septic effect Effects 0.000 description 2
- 239000000924 antiasthmatic agent Substances 0.000 description 2
- 229940125681 anticonvulsant agent Drugs 0.000 description 2
- 239000001961 anticonvulsive agent Substances 0.000 description 2
- 239000000935 antidepressant agent Substances 0.000 description 2
- 229940005513 antidepressants Drugs 0.000 description 2
- 239000003472 antidiabetic agent Substances 0.000 description 2
- 239000002111 antiemetic agent Substances 0.000 description 2
- 229940125683 antiemetic agent Drugs 0.000 description 2
- 239000002220 antihypertensive agent Substances 0.000 description 2
- 229940127088 antihypertensive drug Drugs 0.000 description 2
- 239000002579 antinauseant Substances 0.000 description 2
- 239000002246 antineoplastic agent Substances 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 239000000164 antipsychotic agent Substances 0.000 description 2
- 229940005529 antipsychotics Drugs 0.000 description 2
- 239000002221 antipyretic Substances 0.000 description 2
- 229940125716 antipyretic agent Drugs 0.000 description 2
- 229940043671 antithyroid preparations Drugs 0.000 description 2
- 239000003443 antiviral agent Substances 0.000 description 2
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 description 2
- 239000008122 artificial sweetener Substances 0.000 description 2
- 235000021311 artificial sweeteners Nutrition 0.000 description 2
- 125000003118 aryl group Chemical group 0.000 description 2
- 235000003704 aspartic acid Nutrition 0.000 description 2
- 235000013793 astaxanthin Nutrition 0.000 description 2
- 239000001168 astaxanthin Substances 0.000 description 2
- MQZIGYBFDRPAKN-ZWAPEEGVSA-N astaxanthin Chemical compound C([C@H](O)C(=O)C=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)[C@@H](O)CC1(C)C MQZIGYBFDRPAKN-ZWAPEEGVSA-N 0.000 description 2
- 229940022405 astaxanthin Drugs 0.000 description 2
- GXDALQBWZGODGZ-UHFFFAOYSA-N astemizole Chemical compound C1=CC(OC)=CC=C1CCN1CCC(NC=2N(C3=CC=CC=C3N=2)CC=2C=CC(F)=CC=2)CC1 GXDALQBWZGODGZ-UHFFFAOYSA-N 0.000 description 2
- 239000004176 azorubin Substances 0.000 description 2
- 229940054340 bacillus coagulans Drugs 0.000 description 2
- 235000013871 bee wax Nutrition 0.000 description 2
- 239000012166 beeswax Substances 0.000 description 2
- HUMNYLRZRPPJDN-UHFFFAOYSA-N benzaldehyde Chemical compound O=CC1=CC=CC=C1 HUMNYLRZRPPJDN-UHFFFAOYSA-N 0.000 description 2
- 229960005274 benzocaine Drugs 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 235000021028 berry Nutrition 0.000 description 2
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 description 2
- 235000013734 beta-carotene Nutrition 0.000 description 2
- 239000011648 beta-carotene Substances 0.000 description 2
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 2
- 235000002360 beta-cryptoxanthin Nutrition 0.000 description 2
- DMASLKHVQRHNES-ITUXNECMSA-N beta-cryptoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CCCC2(C)C DMASLKHVQRHNES-ITUXNECMSA-N 0.000 description 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
- 229960002747 betacarotene Drugs 0.000 description 2
- 229960002685 biotin Drugs 0.000 description 2
- 235000020958 biotin Nutrition 0.000 description 2
- 239000011616 biotin Substances 0.000 description 2
- 235000021029 blackberry Nutrition 0.000 description 2
- 235000021014 blueberries Nutrition 0.000 description 2
- 239000004126 brilliant black BN Substances 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 229940095259 butylated hydroxytoluene Drugs 0.000 description 2
- 229960005069 calcium Drugs 0.000 description 2
- 159000000007 calcium salts Chemical class 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- FDSDTBUPSURDBL-LOFNIBRQSA-N canthaxanthin Chemical compound CC=1C(=O)CCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C(=O)CCC1(C)C FDSDTBUPSURDBL-LOFNIBRQSA-N 0.000 description 2
- 235000017663 capsaicin Nutrition 0.000 description 2
- 229960002504 capsaicin Drugs 0.000 description 2
- 235000013877 carbamide Nutrition 0.000 description 2
- 239000004075 cariostatic agent Substances 0.000 description 2
- 229920001525 carrageenan Polymers 0.000 description 2
- ULDHMXUKGWMISQ-UHFFFAOYSA-N carvone Chemical compound CC(=C)C1CC=C(C)C(=O)C1 ULDHMXUKGWMISQ-UHFFFAOYSA-N 0.000 description 2
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 description 2
- 229960001927 cetylpyridinium chloride Drugs 0.000 description 2
- 229940099898 chlorophyllin Drugs 0.000 description 2
- 235000019805 chlorophyllin Nutrition 0.000 description 2
- 229960001231 choline Drugs 0.000 description 2
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 2
- 229910052804 chromium Inorganic materials 0.000 description 2
- 239000011651 chromium Substances 0.000 description 2
- 229940043350 citral Drugs 0.000 description 2
- WTEVQBCEXWBHNA-YFHOEESVSA-N citral B Natural products CC(C)=CCC\C(C)=C/C=O WTEVQBCEXWBHNA-YFHOEESVSA-N 0.000 description 2
- NEHNMFOYXAPHSD-UHFFFAOYSA-N citronellal Chemical compound O=CCC(C)CCC=C(C)C NEHNMFOYXAPHSD-UHFFFAOYSA-N 0.000 description 2
- QMVPMAAFGQKVCJ-UHFFFAOYSA-N citronellol Chemical compound OCCC(C)CCC=C(C)C QMVPMAAFGQKVCJ-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 239000008373 coffee flavor Substances 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000010924 continuous production Methods 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 108010010165 curculin Proteins 0.000 description 2
- 229950009125 cynarine Drugs 0.000 description 2
- YDDUMTOHNYZQPO-BKUKFAEQSA-N cynarine Natural products O[C@H]1C[C@@](C[C@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)(OC(=O)C=Cc3ccc(O)c(O)c3)C(=O)O YDDUMTOHNYZQPO-BKUKFAEQSA-N 0.000 description 2
- ZQSIJRDFPHDXIC-UHFFFAOYSA-N daidzein Chemical compound C1=CC(O)=CC=C1C1=COC2=CC(O)=CC=C2C1=O ZQSIJRDFPHDXIC-UHFFFAOYSA-N 0.000 description 2
- 230000006240 deamidation Effects 0.000 description 2
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 description 2
- 239000000850 decongestant Substances 0.000 description 2
- 229940124581 decongestants Drugs 0.000 description 2
- NEFBYIFKOOEVPA-UHFFFAOYSA-K dicalcium phosphate Chemical compound [Ca+2].[Ca+2].[O-]P([O-])([O-])=O NEFBYIFKOOEVPA-UHFFFAOYSA-K 0.000 description 2
- 229940038472 dicalcium phosphate Drugs 0.000 description 2
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 2
- OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
- 229960000520 diphenhydramine Drugs 0.000 description 2
- SSNZFFBDIMUILS-UHFFFAOYSA-N dodec-2-enal Chemical compound CCCCCCCCCC=CC=O SSNZFFBDIMUILS-UHFFFAOYSA-N 0.000 description 2
- 239000003974 emollient agent Substances 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 229960002179 ephedrine Drugs 0.000 description 2
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 description 2
- 229940030275 epigallocatechin gallate Drugs 0.000 description 2
- 235000012732 erythrosine Nutrition 0.000 description 2
- 239000004174 erythrosine Substances 0.000 description 2
- 229940073505 ethyl vanillin Drugs 0.000 description 2
- 239000010642 eucalyptus oil Substances 0.000 description 2
- 229940044949 eucalyptus oil Drugs 0.000 description 2
- RRAFCDWBNXTKKO-UHFFFAOYSA-N eugenol Chemical compound COC1=CC(CC=C)=CC=C1O RRAFCDWBNXTKKO-UHFFFAOYSA-N 0.000 description 2
- 150000004665 fatty acids Chemical class 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 238000007730 finishing process Methods 0.000 description 2
- 235000019243 flavoxanthin Nutrition 0.000 description 2
- 229940091249 fluoride supplement Drugs 0.000 description 2
- 239000011737 fluorine Substances 0.000 description 2
- 229910052731 fluorine Inorganic materials 0.000 description 2
- 229960000304 folic acid Drugs 0.000 description 2
- 235000019152 folic acid Nutrition 0.000 description 2
- 239000011724 folic acid Substances 0.000 description 2
- 235000007983 food acid Nutrition 0.000 description 2
- 229960002737 fructose Drugs 0.000 description 2
- 239000008369 fruit flavor Substances 0.000 description 2
- 229940113087 geraniol Drugs 0.000 description 2
- NLDDIKRKFXEWBK-AWEZNQCLSA-N gingerol Chemical compound CCCCC[C@H](O)CC(=O)CCC1=CC=C(O)C(OC)=C1 NLDDIKRKFXEWBK-AWEZNQCLSA-N 0.000 description 2
- 235000002780 gingerol Nutrition 0.000 description 2
- JZLXEKNVCWMYHI-UHFFFAOYSA-N gingerol Natural products CCCCC(O)CC(=O)CCC1=CC=C(O)C(OC)=C1 JZLXEKNVCWMYHI-UHFFFAOYSA-N 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 description 2
- 235000021312 gluten Nutrition 0.000 description 2
- 150000004676 glycans Chemical class 0.000 description 2
- 229940075507 glyceryl monostearate Drugs 0.000 description 2
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 2
- 229960004275 glycolic acid Drugs 0.000 description 2
- 235000013761 grape skin extract Nutrition 0.000 description 2
- 230000005484 gravity Effects 0.000 description 2
- 239000004120 green S Substances 0.000 description 2
- 235000012701 green S Nutrition 0.000 description 2
- 235000010417 guar gum Nutrition 0.000 description 2
- 239000000665 guar gum Substances 0.000 description 2
- 229960002154 guar gum Drugs 0.000 description 2
- 229930183009 gymnemic acid Natural products 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 239000003906 humectant Substances 0.000 description 2
- 239000008172 hydrogenated vegetable oil Substances 0.000 description 2
- 230000007062 hydrolysis Effects 0.000 description 2
- 238000006460 hydrolysis reaction Methods 0.000 description 2
- 150000005165 hydroxybenzoic acids Chemical class 0.000 description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 2
- 229910052742 iron Inorganic materials 0.000 description 2
- 235000010213 iron oxides and hydroxides Nutrition 0.000 description 2
- 239000004407 iron oxides and hydroxides Substances 0.000 description 2
- PHTQWCKDNZKARW-UHFFFAOYSA-N isoamylol Chemical compound CC(C)CCO PHTQWCKDNZKARW-UHFFFAOYSA-N 0.000 description 2
- ZYTMANIQRDEHIO-KXUCPTDWSA-N isopulegol Chemical compound C[C@@H]1CC[C@@H](C(C)=C)[C@H](O)C1 ZYTMANIQRDEHIO-KXUCPTDWSA-N 0.000 description 2
- IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
- BJHIKXHVCXFQLS-PQLUHFTBSA-N keto-D-tagatose Chemical compound OC[C@@H](O)[C@H](O)[C@H](O)C(=O)CO BJHIKXHVCXFQLS-PQLUHFTBSA-N 0.000 description 2
- 235000010448 lactitol Nutrition 0.000 description 2
- 239000000832 lactitol Substances 0.000 description 2
- VQHSOMBJVWLPSR-JVCRWLNRSA-N lactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@@H]1O[C@H](CO)[C@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-JVCRWLNRSA-N 0.000 description 2
- 229960003451 lactitol Drugs 0.000 description 2
- XMGQYMWWDOXHJM-UHFFFAOYSA-N limonene Chemical compound CC(=C)C1CCC(C)=CC1 XMGQYMWWDOXHJM-UHFFFAOYSA-N 0.000 description 2
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical compound CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 description 2
- 235000019136 lipoic acid Nutrition 0.000 description 2
- 235000012661 lycopene Nutrition 0.000 description 2
- 239000001751 lycopene Substances 0.000 description 2
- 229960004999 lycopene Drugs 0.000 description 2
- OAIJSZIZWZSQBC-GYZMGTAESA-N lycopene Chemical compound CC(C)=CCC\C(C)=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C(/C)CCC=C(C)C OAIJSZIZWZSQBC-GYZMGTAESA-N 0.000 description 2
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 2
- 239000001095 magnesium carbonate Substances 0.000 description 2
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 2
- 229960001708 magnesium carbonate Drugs 0.000 description 2
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 2
- 239000000347 magnesium hydroxide Substances 0.000 description 2
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 2
- 235000012254 magnesium hydroxide Nutrition 0.000 description 2
- KZMACGJDUUWFCH-UHFFFAOYSA-O malvidin Chemical compound COC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O)=C1 KZMACGJDUUWFCH-UHFFFAOYSA-O 0.000 description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
- 229960000299 mazindol Drugs 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 229940057917 medium chain triglycerides Drugs 0.000 description 2
- 150000004702 methyl esters Chemical class 0.000 description 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 2
- 229960001047 methyl salicylate Drugs 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 206010027599 migraine Diseases 0.000 description 2
- 229910052750 molybdenum Inorganic materials 0.000 description 2
- 239000011733 molybdenum Substances 0.000 description 2
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 230000003533 narcotic effect Effects 0.000 description 2
- 239000000133 nasal decongestant Substances 0.000 description 2
- 229920003052 natural elastomer Polymers 0.000 description 2
- 229920001194 natural rubber Polymers 0.000 description 2
- ZYTMANIQRDEHIO-UHFFFAOYSA-N neo-Isopulegol Natural products CC1CCC(C(C)=C)C(O)C1 ZYTMANIQRDEHIO-UHFFFAOYSA-N 0.000 description 2
- ITVGXXMINPYUHD-CUVHLRMHSA-N neohesperidin dihydrochalcone Chemical compound C1=C(O)C(OC)=CC=C1CCC(=O)C(C(=C1)O)=C(O)C=C1O[C@H]1[C@H](O[C@H]2[C@@H]([C@H](O)[C@@H](O)[C@H](C)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 ITVGXXMINPYUHD-CUVHLRMHSA-N 0.000 description 2
- 229940089953 neohesperidin dihydrochalcone Drugs 0.000 description 2
- 235000010434 neohesperidine DC Nutrition 0.000 description 2
- 229960003512 nicotinic acid Drugs 0.000 description 2
- 235000001968 nicotinic acid Nutrition 0.000 description 2
- 239000011664 nicotinic acid Substances 0.000 description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 description 2
- BDJRBEYXGGNYIS-UHFFFAOYSA-N nonanedioic acid Chemical compound OC(=O)CCCCCCCC(O)=O BDJRBEYXGGNYIS-UHFFFAOYSA-N 0.000 description 2
- 239000001702 nutmeg Substances 0.000 description 2
- 239000002417 nutraceutical Substances 0.000 description 2
- 235000021436 nutraceutical agent Nutrition 0.000 description 2
- 229940127240 opiate Drugs 0.000 description 2
- KHPXUQMNIQBQEV-UHFFFAOYSA-N oxaloacetic acid Chemical compound OC(=O)CC(=O)C(O)=O KHPXUQMNIQBQEV-UHFFFAOYSA-N 0.000 description 2
- WYWIFABBXFUGLM-UHFFFAOYSA-N oxymetazoline Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C)=C1CC1=NCCN1 WYWIFABBXFUGLM-UHFFFAOYSA-N 0.000 description 2
- 239000003346 palm kernel oil Substances 0.000 description 2
- 235000019865 palm kernel oil Nutrition 0.000 description 2
- 229940055726 pantothenic acid Drugs 0.000 description 2
- 235000019161 pantothenic acid Nutrition 0.000 description 2
- 239000011713 pantothenic acid Substances 0.000 description 2
- 239000001688 paprika extract Substances 0.000 description 2
- 229960005489 paracetamol Drugs 0.000 description 2
- 235000019809 paraffin wax Nutrition 0.000 description 2
- 230000036961 partial effect Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 238000005453 pelletization Methods 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- 235000019271 petrolatum Nutrition 0.000 description 2
- 229960003742 phenol Drugs 0.000 description 2
- DHHVAGZRUROJKS-UHFFFAOYSA-N phentermine Chemical compound CC(C)(N)CC1=CC=CC=C1 DHHVAGZRUROJKS-UHFFFAOYSA-N 0.000 description 2
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 2
- WLJVNTCWHIRURA-UHFFFAOYSA-N pimelic acid Chemical compound OC(=O)CCCCCC(O)=O WLJVNTCWHIRURA-UHFFFAOYSA-N 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 239000001103 potassium chloride Substances 0.000 description 2
- 235000011164 potassium chloride Nutrition 0.000 description 2
- 235000003270 potassium fluoride Nutrition 0.000 description 2
- FGIUAXJPYTZDNR-UHFFFAOYSA-N potassium nitrate Chemical compound [K+].[O-][N+]([O-])=O FGIUAXJPYTZDNR-UHFFFAOYSA-N 0.000 description 2
- 235000013772 propylene glycol Nutrition 0.000 description 2
- 229940093625 propylene glycol monostearate Drugs 0.000 description 2
- 235000012752 quinoline yellow Nutrition 0.000 description 2
- 239000004172 quinoline yellow Substances 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 235000019246 rhodoxanthin Nutrition 0.000 description 2
- 235000019192 riboflavin Nutrition 0.000 description 2
- 239000002151 riboflavin Substances 0.000 description 2
- 229960002477 riboflavin Drugs 0.000 description 2
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical class C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
- 235000002020 sage Nutrition 0.000 description 2
- SMQUZDBALVYZAC-UHFFFAOYSA-N salicylaldehyde Chemical compound OC1=CC=CC=C1C=O SMQUZDBALVYZAC-UHFFFAOYSA-N 0.000 description 2
- 239000001296 salvia officinalis l. Substances 0.000 description 2
- CXMXRPHRNRROMY-UHFFFAOYSA-N sebacic acid Chemical compound OC(=O)CCCCCCCCC(O)=O CXMXRPHRNRROMY-UHFFFAOYSA-N 0.000 description 2
- 229910052711 selenium Inorganic materials 0.000 description 2
- 239000011669 selenium Substances 0.000 description 2
- 238000007493 shaping process Methods 0.000 description 2
- 229910001961 silver nitrate Inorganic materials 0.000 description 2
- 229960001516 silver nitrate Drugs 0.000 description 2
- 239000011775 sodium fluoride Substances 0.000 description 2
- 235000013024 sodium fluoride Nutrition 0.000 description 2
- 229960000414 sodium fluoride Drugs 0.000 description 2
- 229960004711 sodium monofluorophosphate Drugs 0.000 description 2
- 235000019832 sodium triphosphate Nutrition 0.000 description 2
- 235000012424 soybean oil Nutrition 0.000 description 2
- TYFQFVWCELRYAO-UHFFFAOYSA-N suberic acid Chemical compound OC(=O)CCCCCCC(O)=O TYFQFVWCELRYAO-UHFFFAOYSA-N 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- 229920003051 synthetic elastomer Polymers 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- ULSUXBXHSYSGDT-UHFFFAOYSA-N tangeretin Chemical compound C1=CC(OC)=CC=C1C1=CC(=O)C2=C(OC)C(OC)=C(OC)C(OC)=C2O1 ULSUXBXHSYSGDT-UHFFFAOYSA-N 0.000 description 2
- 235000012756 tartrazine Nutrition 0.000 description 2
- 239000004149 tartrazine Substances 0.000 description 2
- 235000013616 tea Nutrition 0.000 description 2
- 229940034887 tenuate Drugs 0.000 description 2
- GMMAPXRGRVJYJY-UHFFFAOYSA-J tetrasodium 4-acetamido-5-hydroxy-6-[[7-sulfonato-4-[(4-sulfonatophenyl)diazenyl]naphthalen-1-yl]diazenyl]naphthalene-1,7-disulfonate Chemical compound [Na+].[Na+].[Na+].[Na+].OC1=C2C(NC(=O)C)=CC=C(S([O-])(=O)=O)C2=CC(S([O-])(=O)=O)=C1N=NC(C1=CC(=CC=C11)S([O-])(=O)=O)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 GMMAPXRGRVJYJY-UHFFFAOYSA-J 0.000 description 2
- 235000010436 thaumatin Nutrition 0.000 description 2
- 239000000892 thaumatin Substances 0.000 description 2
- 235000019157 thiamine Nutrition 0.000 description 2
- 229960003495 thiamine Drugs 0.000 description 2
- 239000011721 thiamine Substances 0.000 description 2
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 2
- 229960002663 thioctic acid Drugs 0.000 description 2
- 239000001585 thymus vulgaris Substances 0.000 description 2
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 2
- ZCIHMQAPACOQHT-ZGMPDRQDSA-N trans-isorenieratene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/c1c(C)ccc(C)c1C)C=CC=C(/C)C=Cc2c(C)ccc(C)c2C ZCIHMQAPACOQHT-ZGMPDRQDSA-N 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 229940074410 trehalose Drugs 0.000 description 2
- 229940078499 tricalcium phosphate Drugs 0.000 description 2
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 2
- 235000019731 tricalcium phosphate Nutrition 0.000 description 2
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 2
- 239000012588 trypsin Substances 0.000 description 2
- 229960001322 trypsin Drugs 0.000 description 2
- HGBOYTHUEUWSSQ-UHFFFAOYSA-N valeric aldehyde Natural products CCCCC=O HGBOYTHUEUWSSQ-UHFFFAOYSA-N 0.000 description 2
- WJUFSDZVCOTFON-UHFFFAOYSA-N veratraldehyde Chemical compound COC1=CC=C(C=O)C=C1OC WJUFSDZVCOTFON-UHFFFAOYSA-N 0.000 description 2
- 239000011710 vitamin D Substances 0.000 description 2
- 235000019166 vitamin D Nutrition 0.000 description 2
- 150000003710 vitamin D derivatives Chemical class 0.000 description 2
- 239000011712 vitamin K Substances 0.000 description 2
- 235000019168 vitamin K Nutrition 0.000 description 2
- 150000003721 vitamin K derivatives Chemical class 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- 229940046008 vitamin d Drugs 0.000 description 2
- 229940046010 vitamin k Drugs 0.000 description 2
- 229920001285 xanthan gum Polymers 0.000 description 2
- 235000010493 xanthan gum Nutrition 0.000 description 2
- 239000000230 xanthan gum Substances 0.000 description 2
- 229940082509 xanthan gum Drugs 0.000 description 2
- 239000010457 zeolite Substances 0.000 description 2
- VNDYJBBGRKZCSX-UHFFFAOYSA-L zinc bromide Chemical compound Br[Zn]Br VNDYJBBGRKZCSX-UHFFFAOYSA-L 0.000 description 2
- 239000011746 zinc citrate Substances 0.000 description 2
- 235000006076 zinc citrate Nutrition 0.000 description 2
- 229940068475 zinc citrate Drugs 0.000 description 2
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 2
- BHHYHSUAOQUXJK-UHFFFAOYSA-L zinc fluoride Chemical compound F[Zn]F BHHYHSUAOQUXJK-UHFFFAOYSA-L 0.000 description 2
- UAYWVJHJZHQCIE-UHFFFAOYSA-L zinc iodide Chemical compound I[Zn]I UAYWVJHJZHQCIE-UHFFFAOYSA-L 0.000 description 2
- ONDPHDOFVYQSGI-UHFFFAOYSA-N zinc nitrate Chemical compound [Zn+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O ONDPHDOFVYQSGI-UHFFFAOYSA-N 0.000 description 2
- OJYLAHXKWMRDGS-UHFFFAOYSA-N zingerone Chemical compound COC1=CC(CCC(C)=O)=CC=C1O OJYLAHXKWMRDGS-UHFFFAOYSA-N 0.000 description 2
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 2
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 description 1
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 description 1
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 description 1
- WTARULDDTDQWMU-RKDXNWHRSA-N (+)-β-pinene Chemical compound C1[C@H]2C(C)(C)[C@@H]1CCC2=C WTARULDDTDQWMU-RKDXNWHRSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- WTARULDDTDQWMU-IUCAKERBSA-N (-)-Nopinene Natural products C1[C@@H]2C(C)(C)[C@H]1CCC2=C WTARULDDTDQWMU-IUCAKERBSA-N 0.000 description 1
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 description 1
- REPVLJRCJUVQFA-UHFFFAOYSA-N (-)-isopinocampheol Natural products C1C(O)C(C)C2C(C)(C)C1C2 REPVLJRCJUVQFA-UHFFFAOYSA-N 0.000 description 1
- AKNNEGZIBPJZJG-MSOLQXFVSA-N (-)-noscapine Chemical compound CN1CCC2=CC=3OCOC=3C(OC)=C2[C@@H]1[C@@H]1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-MSOLQXFVSA-N 0.000 description 1
- TXUICONDJPYNPY-UHFFFAOYSA-N (1,10,13-trimethyl-3-oxo-4,5,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl) heptanoate Chemical compound C1CC2CC(=O)C=C(C)C2(C)C2C1C1CCC(OC(=O)CCCCCC)C1(C)CC2 TXUICONDJPYNPY-UHFFFAOYSA-N 0.000 description 1
- BXJYLJLZLMXRSH-UHFFFAOYSA-N (1-methyl-4-propan-2-ylcyclohexyl) 3-hydroxybutanoate Chemical compound CC(O)CC(=O)OC1(C)CCC(C(C)C)CC1 BXJYLJLZLMXRSH-UHFFFAOYSA-N 0.000 description 1
- 239000001871 (1R,2R,5S)-5-methyl-2-prop-1-en-2-ylcyclohexan-1-ol Substances 0.000 description 1
- WQFGPARDTSBVLU-UHFFFAOYSA-N (1R,2S,3S,4R)-p-Menthane-2,3-diol Chemical compound CC(C)C1CCC(C)C(O)C1O WQFGPARDTSBVLU-UHFFFAOYSA-N 0.000 description 1
- 239000001112 (2E)-1,1-diethoxy-3,7-dimethylocta-2,6-diene Substances 0.000 description 1
- MBDOYVRWFFCFHM-SNAWJCMRSA-N (2E)-hexenal Chemical compound CCC\C=C\C=O MBDOYVRWFFCFHM-SNAWJCMRSA-N 0.000 description 1
- UQXZSKHOYOHVIH-UGDNZRGBSA-N (2R,3R,4S,5S,6R)-2-[(2R,3S,4S,5S)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 UQXZSKHOYOHVIH-UGDNZRGBSA-N 0.000 description 1
- SDOFMBGMRVAJNF-KVTDHHQDSA-N (2r,3r,4r,5r)-6-aminohexane-1,2,3,4,5-pentol Chemical compound NC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO SDOFMBGMRVAJNF-KVTDHHQDSA-N 0.000 description 1
- BPQOIESVQZIMHQ-UGDNZRGBSA-N (2r,3r,4s,5s,6s)-2-[(2r,3s,4s,5s)-2,5-bis(chloromethyl)-3,4-dihydroxyoxolan-2-yl]oxy-6-(chloromethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@H](O)[C@@H](CCl)O[C@@]1(CCl)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BPQOIESVQZIMHQ-UGDNZRGBSA-N 0.000 description 1
- RDJGLLICXDHJDY-NSHDSACASA-N (2s)-2-(3-phenoxyphenyl)propanoic acid Chemical compound OC(=O)[C@@H](C)C1=CC=CC(OC=2C=CC=CC=2)=C1 RDJGLLICXDHJDY-NSHDSACASA-N 0.000 description 1
- FYGDTMLNYKFZSV-URKRLVJHSA-N (2s,3r,4s,5s,6r)-2-[(2r,4r,5r,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5r,6s)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1[C@@H](CO)O[C@@H](OC2[C@H](O[C@H](O)[C@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O FYGDTMLNYKFZSV-URKRLVJHSA-N 0.000 description 1
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 description 1
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 description 1
- ABTRFGSPYXCGMR-KXQOOQHDSA-N (3R)-beta,psi-caroten-3-ol Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C ABTRFGSPYXCGMR-KXQOOQHDSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-JLGXGRJMSA-N (3R,3'R)-beta,beta-carotene-3,3'-diol Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-JLGXGRJMSA-N 0.000 description 1
- VYIRVAXUEZSDNC-TXDLOWMYSA-N (3R,3'S,5'R)-3,3'-dihydroxy-beta-kappa-caroten-6'-one Chemical compound C([C@H](O)CC=1C)C(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC(=O)[C@]1(C)C[C@@H](O)CC1(C)C VYIRVAXUEZSDNC-TXDLOWMYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-LNVDRNJUSA-N (3r,5r)-1,3,4,5-tetrahydroxycyclohexane-1-carboxylic acid Chemical compound O[C@@H]1CC(O)(C(O)=O)C[C@@H](O)C1O AAWZDTNXLSGCEK-LNVDRNJUSA-N 0.000 description 1
- NUFKRGBSZPCGQB-FLBSXDLDSA-N (3s)-3-amino-4-oxo-4-[[(2r)-1-oxo-1-[(2,2,4,4-tetramethylthietan-3-yl)amino]propan-2-yl]amino]butanoic acid;pentahydrate Chemical compound O.O.O.O.O.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C.OC(=O)C[C@H](N)C(=O)N[C@H](C)C(=O)NC1C(C)(C)SC1(C)C NUFKRGBSZPCGQB-FLBSXDLDSA-N 0.000 description 1
- YQSHYGCCYVPRDI-UHFFFAOYSA-N (4-propan-2-ylphenyl)methanamine Chemical compound CC(C)C1=CC=C(CN)C=C1 YQSHYGCCYVPRDI-UHFFFAOYSA-N 0.000 description 1
- DKSZLDSPXIWGFO-BLOJGBSASA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;phosphoric acid;hydrate Chemical compound O.OP(O)(O)=O.OP(O)(O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC DKSZLDSPXIWGFO-BLOJGBSASA-N 0.000 description 1
- BCXHDORHMMZBBZ-DORFAMGDSA-N (4r,4ar,7s,7ar,12bs)-9-methoxy-3-methyl-2,4,4a,7,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-7-ol;sulfuric acid Chemical compound OS(O)(=O)=O.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC.C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC BCXHDORHMMZBBZ-DORFAMGDSA-N 0.000 description 1
- 239000001605 (5-methyl-2-propan-2-ylcyclohexyl) acetate Substances 0.000 description 1
- OQWKEEOHDMUXEO-UHFFFAOYSA-N (6)-shogaol Natural products CCCCCC=CC(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-UHFFFAOYSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- QMVPMAAFGQKVCJ-SNVBAGLBSA-N (R)-(+)-citronellol Natural products OCC[C@H](C)CCC=C(C)C QMVPMAAFGQKVCJ-SNVBAGLBSA-N 0.000 description 1
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 description 1
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 description 1
- IZFHEQBZOYJLPK-SSDOTTSWSA-N (R)-dihydrolipoic acid Chemical compound OC(=O)CCCC[C@@H](S)CCS IZFHEQBZOYJLPK-SSDOTTSWSA-N 0.000 description 1
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 description 1
- WXUAQHNMJWJLTG-VKHMYHEASA-N (S)-methylsuccinic acid Chemical compound OC(=O)[C@@H](C)CC(O)=O WXUAQHNMJWJLTG-VKHMYHEASA-N 0.000 description 1
- FTVWIRXFELQLPI-ZDUSSCGKSA-N (S)-naringenin Chemical compound C1=CC(O)=CC=C1[C@H]1OC2=CC(O)=CC(O)=C2C(=O)C1 FTVWIRXFELQLPI-ZDUSSCGKSA-N 0.000 description 1
- GJJVAFUKOBZPCB-ZGRPYONQSA-N (r)-3,4-dihydro-2-methyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol Chemical class OC1=CC=C2OC(CC/C=C(C)/CC/C=C(C)/CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-ZGRPYONQSA-N 0.000 description 1
- RBNPOMFGQQGHHO-UHFFFAOYSA-N -2,3-Dihydroxypropanoic acid Natural products OCC(O)C(O)=O RBNPOMFGQQGHHO-UHFFFAOYSA-N 0.000 description 1
- NTXGFKWLJFHGGJ-ACCUITESSA-N 1,1-Diethoxy-3,7-dimethyl-2,6-octadiene Chemical compound CCOC(OCC)\C=C(/C)CCC=C(C)C NTXGFKWLJFHGGJ-ACCUITESSA-N 0.000 description 1
- UENOQWSWMYJKIW-UHFFFAOYSA-N 1,2,2-trimethylcyclohexan-1-ol Chemical compound CC1(C)CCCCC1(C)O UENOQWSWMYJKIW-UHFFFAOYSA-N 0.000 description 1
- TUSDEZXZIZRFGC-UHFFFAOYSA-N 1-O-galloyl-3,6-(R)-HHDP-beta-D-glucose Natural products OC1C(O2)COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC1C(O)C2OC(=O)C1=CC(O)=C(O)C(O)=C1 TUSDEZXZIZRFGC-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- VEPOHXYIFQMVHW-XOZOLZJESA-N 2,3-dihydroxybutanedioic acid (2S,3S)-3,4-dimethyl-2-phenylmorpholine Chemical compound OC(C(O)C(O)=O)C(O)=O.C[C@H]1[C@@H](OCCN1C)c1ccccc1 VEPOHXYIFQMVHW-XOZOLZJESA-N 0.000 description 1
- CIVCELMLGDGMKZ-UHFFFAOYSA-N 2,4-dichloro-6-methylpyridine-3-carboxylic acid Chemical compound CC1=CC(Cl)=C(C(O)=O)C(Cl)=N1 CIVCELMLGDGMKZ-UHFFFAOYSA-N 0.000 description 1
- 229940029225 2,6-dimethyl-5-heptenal Drugs 0.000 description 1
- CBOBADCVMLMQRW-UHFFFAOYSA-N 2,6-dimethyloctanal Chemical compound CCC(C)CCCC(C)C=O CBOBADCVMLMQRW-UHFFFAOYSA-N 0.000 description 1
- LOVYCUYJRWLTSU-UHFFFAOYSA-N 2-(3,4-dichlorophenoxy)-n,n-diethylethanamine Chemical compound CCN(CC)CCOC1=CC=C(Cl)C(Cl)=C1 LOVYCUYJRWLTSU-UHFFFAOYSA-N 0.000 description 1
- UNNGUFMVYQJGTD-UHFFFAOYSA-N 2-Ethylbutanal Chemical compound CCC(CC)C=O UNNGUFMVYQJGTD-UHFFFAOYSA-N 0.000 description 1
- HMKKIXGYKWDQSV-SDNWHVSQSA-N 2-Pentyl-3-phenyl-2-propenal Chemical compound CCCCC\C(C=O)=C/C1=CC=CC=C1 HMKKIXGYKWDQSV-SDNWHVSQSA-N 0.000 description 1
- LFJJOPDNPVFCNZ-UHFFFAOYSA-N 2-[hexadecanoyl(methyl)amino]acetic acid Chemical class CCCCCCCCCCCCCCCC(=O)N(C)CC(O)=O LFJJOPDNPVFCNZ-UHFFFAOYSA-N 0.000 description 1
- NGOZDSMNMIRDFP-UHFFFAOYSA-N 2-[methyl(tetradecanoyl)amino]acetic acid Chemical class CCCCCCCCCCCCCC(=O)N(C)CC(O)=O NGOZDSMNMIRDFP-UHFFFAOYSA-N 0.000 description 1
- DEOUZFWSQWEPGE-UHFFFAOYSA-N 2-methylheptanamide Chemical compound CCCCCC(C)C(N)=O DEOUZFWSQWEPGE-UHFFFAOYSA-N 0.000 description 1
- WLJVXDMOQOGPHL-PPJXEINESA-N 2-phenylacetic acid Chemical compound O[14C](=O)CC1=CC=CC=C1 WLJVXDMOQOGPHL-PPJXEINESA-N 0.000 description 1
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
- UOXYCZBLTLAQBY-UHFFFAOYSA-N 2-sulfanylcyclodecan-1-one Chemical compound SC1CCCCCCCCC1=O UOXYCZBLTLAQBY-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- MIDXCONKKJTLDX-UHFFFAOYSA-N 3,5-dimethylcyclopentane-1,2-dione Chemical compound CC1CC(C)C(=O)C1=O MIDXCONKKJTLDX-UHFFFAOYSA-N 0.000 description 1
- AYERSDHOTKHEDA-UHFFFAOYSA-N 3-(1-methyl-4-propan-2-ylcyclohexyl)oxybutan-1-ol Chemical compound CC(C)C1CCC(C)(OC(C)CCO)CC1 AYERSDHOTKHEDA-UHFFFAOYSA-N 0.000 description 1
- DCNFPFNLHFFBFM-UHFFFAOYSA-N 3-(1-methyl-4-propan-2-ylcyclohexyl)oxypropan-1-ol Chemical compound CC(C)C1CCC(C)(OCCCO)CC1 DCNFPFNLHFFBFM-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-FWCWNIRPSA-N 3-O-Caffeoylquinic acid Natural products O[C@H]1[C@@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-FWCWNIRPSA-N 0.000 description 1
- AJBZENLMTKDAEK-UHFFFAOYSA-N 3a,5a,5b,8,8,11a-hexamethyl-1-prop-1-en-2-yl-1,2,3,4,5,6,7,7a,9,10,11,11b,12,13,13a,13b-hexadecahydrocyclopenta[a]chrysene-4,9-diol Chemical compound CC12CCC(O)C(C)(C)C1CCC(C1(C)CC3O)(C)C2CCC1C1C3(C)CCC1C(=C)C AJBZENLMTKDAEK-UHFFFAOYSA-N 0.000 description 1
- WFJIVOKAWHGMBH-UHFFFAOYSA-N 4-hexylbenzene-1,3-diol Chemical compound CCCCCCC1=CC=C(O)C=C1O WFJIVOKAWHGMBH-UHFFFAOYSA-N 0.000 description 1
- DCTLYFZHFGENCW-UUOKFMHZSA-N 5'-xanthylic acid Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC(=O)NC2=O)=C2N=C1 DCTLYFZHFGENCW-UUOKFMHZSA-N 0.000 description 1
- CTMTYSVTTGVYAW-FRRDWIJNSA-N 5-[(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl]oxy-5-oxopentanoic acid Chemical class CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCCC(O)=O CTMTYSVTTGVYAW-FRRDWIJNSA-N 0.000 description 1
- FINKDHKJINNQQW-UHFFFAOYSA-N 5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical class CC(C)C1CCC(C)CC1C(N)=O FINKDHKJINNQQW-UHFFFAOYSA-N 0.000 description 1
- 108010011619 6-Phytase Proteins 0.000 description 1
- DFMMVLFMMAQXHZ-DOKBYWHISA-N 8'-apo-beta,psi-caroten-8'-al Chemical compound O=CC(/C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C1=C(C)CCCC1(C)C DFMMVLFMMAQXHZ-DOKBYWHISA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 208000002874 Acne Vulgaris Diseases 0.000 description 1
- 241000906543 Actaea racemosa Species 0.000 description 1
- 241000251468 Actinopterygii Species 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 235000001674 Agaricus brunnescens Nutrition 0.000 description 1
- 239000004377 Alitame Substances 0.000 description 1
- 244000291564 Allium cepa Species 0.000 description 1
- 235000002732 Allium cepa var. cepa Nutrition 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 235000002961 Aloe barbadensis Nutrition 0.000 description 1
- 244000144927 Aloe barbadensis Species 0.000 description 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 1
- WLDHEUZGFKACJH-ZRUFZDNISA-K Amaranth Chemical compound [Na+].[Na+].[Na+].C12=CC=C(S([O-])(=O)=O)C=C2C=C(S([O-])(=O)=O)C(O)=C1\N=N\C1=CC=C(S([O-])(=O)=O)C2=CC=CC=C12 WLDHEUZGFKACJH-ZRUFZDNISA-K 0.000 description 1
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 1
- 244000247812 Amorphophallus rivieri Species 0.000 description 1
- 235000001206 Amorphophallus rivieri Nutrition 0.000 description 1
- 244000144730 Amygdalus persica Species 0.000 description 1
- 239000004382 Amylase Substances 0.000 description 1
- 108010065511 Amylases Proteins 0.000 description 1
- 102000013142 Amylases Human genes 0.000 description 1
- 244000099147 Ananas comosus Species 0.000 description 1
- 235000007119 Ananas comosus Nutrition 0.000 description 1
- 240000000662 Anethum graveolens Species 0.000 description 1
- 244000061520 Angelica archangelica Species 0.000 description 1
- 235000011514 Anogeissus latifolia Nutrition 0.000 description 1
- 244000106483 Anogeissus latifolia Species 0.000 description 1
- 240000007087 Apium graveolens Species 0.000 description 1
- 235000015849 Apium graveolens Dulce Group Nutrition 0.000 description 1
- 235000010591 Appio Nutrition 0.000 description 1
- 239000004475 Arginine Substances 0.000 description 1
- 235000003092 Artemisia dracunculus Nutrition 0.000 description 1
- 240000001851 Artemisia dracunculus Species 0.000 description 1
- 241000416162 Astragalus gummifer Species 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- HRQKOYFGHJYEFS-UHFFFAOYSA-N Beta psi-carotene Chemical compound CC(C)=CCCC(C)=CC=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C HRQKOYFGHJYEFS-UHFFFAOYSA-N 0.000 description 1
- 229920002498 Beta-glucan Polymers 0.000 description 1
- DHHFDKNIEVKVKS-FMOSSLLZSA-N Betanin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC(C(=C1)O)=CC(C[C@H]2C([O-])=O)=C1[N+]2=C\C=C\1C=C(C(O)=O)N[C@H](C(O)=O)C/1 DHHFDKNIEVKVKS-FMOSSLLZSA-N 0.000 description 1
- DHHFDKNIEVKVKS-MVUYWVKGSA-N Betanin Natural products O=C(O)[C@@H]1NC(C(=O)O)=C/C(=C\C=[N+]/2\[C@@H](C(=O)[O-])Cc3c\2cc(O)c(O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)c3)/C1 DHHFDKNIEVKVKS-MVUYWVKGSA-N 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
- 229910000014 Bismuth subcarbonate Inorganic materials 0.000 description 1
- RAFGELQLHMBRHD-VFYVRILKSA-N Bixin Natural products COC(=O)C=CC(=C/C=C/C(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)/C)C RAFGELQLHMBRHD-VFYVRILKSA-N 0.000 description 1
- 241001474374 Blennius Species 0.000 description 1
- 244000056139 Brassica cretica Species 0.000 description 1
- 235000003351 Brassica cretica Nutrition 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000003899 Brassica oleracea var acephala Nutrition 0.000 description 1
- 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 1
- 235000001169 Brassica oleracea var oleracea Nutrition 0.000 description 1
- 235000003343 Brassica rupestris Nutrition 0.000 description 1
- SGHZXLIDFTYFHQ-UHFFFAOYSA-L Brilliant Blue Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 SGHZXLIDFTYFHQ-UHFFFAOYSA-L 0.000 description 1
- 235000004936 Bromus mango Nutrition 0.000 description 1
- DCFGGGCMICWSJX-SNAWJCMRSA-N Butyl oleate sulfate Chemical compound CCCCOC(=O)CCCCCCC\C=C\CCCCCCCCOS(O)(=O)=O DCFGGGCMICWSJX-SNAWJCMRSA-N 0.000 description 1
- RTMBGDBBDQKNNZ-UHFFFAOYSA-L C.I. Acid Blue 3 Chemical compound [Ca+2].C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1.C1=CC(N(CC)CC)=CC=C1C(C=1C(=CC(=C(O)C=1)S([O-])(=O)=O)S([O-])(=O)=O)=C1C=CC(=[N+](CC)CC)C=C1 RTMBGDBBDQKNNZ-UHFFFAOYSA-L 0.000 description 1
- PZIRUHCJZBGLDY-UHFFFAOYSA-N Caffeoylquinic acid Natural products CC(CCC(=O)C(C)C1C(=O)CC2C3CC(O)C4CC(O)CCC4(C)C3CCC12C)C(=O)O PZIRUHCJZBGLDY-UHFFFAOYSA-N 0.000 description 1
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
- 239000004343 Calcium peroxide Substances 0.000 description 1
- 235000003880 Calendula Nutrition 0.000 description 1
- 240000001432 Calendula officinalis Species 0.000 description 1
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 description 1
- VYIRVAXUEZSDNC-LOFNIBRQSA-N Capsanthyn Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CC(O)CC2(C)C VYIRVAXUEZSDNC-LOFNIBRQSA-N 0.000 description 1
- 235000007862 Capsicum baccatum Nutrition 0.000 description 1
- 240000008574 Capsicum frutescens Species 0.000 description 1
- 244000284152 Carapichea ipecacuanha Species 0.000 description 1
- AKJDEXBCRLOVTH-UHFFFAOYSA-N Carbetapentane citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.C=1C=CC=CC=1C1(C(=O)OCCOCCN(CC)CC)CCCC1 AKJDEXBCRLOVTH-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- 235000009467 Carica papaya Nutrition 0.000 description 1
- 240000006432 Carica papaya Species 0.000 description 1
- YSVBPNGJESBVRM-ZPZFBZIMSA-L Carmoisine Chemical compound [Na+].[Na+].C1=CC=C2C(/N=N/C3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-ZPZFBZIMSA-L 0.000 description 1
- 108010078791 Carrier Proteins Proteins 0.000 description 1
- 235000005747 Carum carvi Nutrition 0.000 description 1
- 240000000467 Carum carvi Species 0.000 description 1
- 244000302413 Carum copticum Species 0.000 description 1
- 235000007034 Carum copticum Nutrition 0.000 description 1
- 239000005973 Carvone Substances 0.000 description 1
- 102000005575 Cellulases Human genes 0.000 description 1
- 108010084185 Cellulases Proteins 0.000 description 1
- 235000013912 Ceratonia siliqua Nutrition 0.000 description 1
- 240000008886 Ceratonia siliqua Species 0.000 description 1
- ZKLPARSLTMPFCP-UHFFFAOYSA-N Cetirizine Chemical compound C1CN(CCOCC(=O)O)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZKLPARSLTMPFCP-UHFFFAOYSA-N 0.000 description 1
- NPBVQXIMTZKSBA-UHFFFAOYSA-N Chavibetol Natural products COC1=CC=C(CC=C)C=C1O NPBVQXIMTZKSBA-UHFFFAOYSA-N 0.000 description 1
- 229920001412 Chicle Polymers 0.000 description 1
- 229920001661 Chitosan Polymers 0.000 description 1
- XYGSFNHCFFAJPO-UHFFFAOYSA-N Chlophedianol hydrochloride Chemical compound Cl.C=1C=CC=C(Cl)C=1C(O)(CCN(C)C)C1=CC=CC=C1 XYGSFNHCFFAJPO-UHFFFAOYSA-N 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 239000004155 Chlorine dioxide Substances 0.000 description 1
- ZCKAMNXUHHNZLN-UHFFFAOYSA-N Chlorphentermine Chemical compound CC(C)(N)CC1=CC=C(Cl)C=C1 ZCKAMNXUHHNZLN-UHFFFAOYSA-N 0.000 description 1
- IFYMEZNJCAQUME-APKWKYNESA-N Chrysanthemaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C1OC2(C)CC(O)CC(C)(C)C2=C1)C=CC=C(/C)C=CC3=C(C)CC(O)CC3(C)C IFYMEZNJCAQUME-APKWKYNESA-N 0.000 description 1
- 241000723346 Cinnamomum camphora Species 0.000 description 1
- 241000911175 Citharexylum caudatum Species 0.000 description 1
- XFTRTWQBIOMVPK-YFKPBYRVSA-N Citramalic acid Natural products OC(=O)[C@](O)(C)CC(O)=O XFTRTWQBIOMVPK-YFKPBYRVSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 235000019499 Citrus oil Nutrition 0.000 description 1
- 241001672694 Citrus reticulata Species 0.000 description 1
- 102000008186 Collagen Human genes 0.000 description 1
- 108010035532 Collagen Proteins 0.000 description 1
- 235000010919 Copernicia prunifera Nutrition 0.000 description 1
- 244000180278 Copernicia prunifera Species 0.000 description 1
- AAWZDTNXLSGCEK-UHFFFAOYSA-N Cordycepinsaeure Natural products OC1CC(O)(C(O)=O)CC(O)C1O AAWZDTNXLSGCEK-UHFFFAOYSA-N 0.000 description 1
- 235000002787 Coriandrum sativum Nutrition 0.000 description 1
- 244000018436 Coriandrum sativum Species 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 235000015655 Crocus sativus Nutrition 0.000 description 1
- 244000124209 Crocus sativus Species 0.000 description 1
- 239000004212 Cryptoxanthin Substances 0.000 description 1
- 235000007129 Cuminum cyminum Nutrition 0.000 description 1
- 244000304337 Cuminum cyminum Species 0.000 description 1
- 235000003392 Curcuma domestica Nutrition 0.000 description 1
- 244000008991 Curcuma longa Species 0.000 description 1
- 239000001879 Curdlan Substances 0.000 description 1
- 229920002558 Curdlan Polymers 0.000 description 1
- UDIPTWFVPPPURJ-UHFFFAOYSA-M Cyclamate Chemical class [Na+].[O-]S(=O)(=O)NC1CCCCC1 UDIPTWFVPPPURJ-UHFFFAOYSA-M 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- CKLJMWTZIZZHCS-UHFFFAOYSA-N D-OH-Asp Natural products OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- RBNPOMFGQQGHHO-UWTATZPHSA-N D-glyceric acid Chemical compound OC[C@@H](O)C(O)=O RBNPOMFGQQGHHO-UWTATZPHSA-N 0.000 description 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 description 1
- XHXUANMFYXWVNG-UHFFFAOYSA-N D-menthyl acetate Natural products CC(C)C1CCC(C)CC1OC(C)=O XHXUANMFYXWVNG-UHFFFAOYSA-N 0.000 description 1
- ZAQJHHRNXZUBTE-NQXXGFSBSA-N D-ribulose Chemical compound OC[C@@H](O)[C@@H](O)C(=O)CO ZAQJHHRNXZUBTE-NQXXGFSBSA-N 0.000 description 1
- ZAQJHHRNXZUBTE-UHFFFAOYSA-N D-threo-2-Pentulose Natural products OCC(O)C(O)C(=O)CO ZAQJHHRNXZUBTE-UHFFFAOYSA-N 0.000 description 1
- ODBLHEXUDAPZAU-ZAFYKAAXSA-N D-threo-isocitric acid Chemical compound OC(=O)[C@H](O)[C@@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-ZAFYKAAXSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- GCPYCNBGGPHOBD-UHFFFAOYSA-N Delphinidin Natural products OC1=Cc2c(O)cc(O)cc2OC1=C3C=C(O)C(=O)C(=C3)O GCPYCNBGGPHOBD-UHFFFAOYSA-N 0.000 description 1
- UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
- 208000006558 Dental Calculus Diseases 0.000 description 1
- 108010001682 Dextranase Proteins 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000012848 Dextrorphan Substances 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- TUSIZTVSUSBSQI-UHFFFAOYSA-N Dihydrocarveol acetate Chemical compound CC1CCC(C(C)=C)CC1OC(C)=O TUSIZTVSUSBSQI-UHFFFAOYSA-N 0.000 description 1
- ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 1
- QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical class [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 1
- AANLCWYVVNBGEE-IDIVVRGQSA-L Disodium inosinate Chemical compound [Na+].[Na+].O[C@@H]1[C@H](O)[C@@H](COP([O-])([O-])=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 AANLCWYVVNBGEE-IDIVVRGQSA-L 0.000 description 1
- 240000000896 Dyera costulata Species 0.000 description 1
- 244000133098 Echinacea angustifolia Species 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 201000009273 Endometriosis Diseases 0.000 description 1
- 108010059378 Endopeptidases Proteins 0.000 description 1
- 102000005593 Endopeptidases Human genes 0.000 description 1
- 241000218671 Ephedra Species 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 235000014755 Eruca sativa Nutrition 0.000 description 1
- 244000024675 Eruca sativa Species 0.000 description 1
- 239000001856 Ethyl cellulose Substances 0.000 description 1
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
- QUSNBJAOOMFDIB-UHFFFAOYSA-N Ethylamine Chemical compound CCN QUSNBJAOOMFDIB-UHFFFAOYSA-N 0.000 description 1
- 244000004281 Eucalyptus maculata Species 0.000 description 1
- 239000005770 Eugenol Substances 0.000 description 1
- JUTKIGGQRLHTJN-UHFFFAOYSA-N Eugenyl formate Chemical compound COC1=CC(CC=C)=CC=C1OC=O JUTKIGGQRLHTJN-UHFFFAOYSA-N 0.000 description 1
- 239000001263 FEMA 3042 Substances 0.000 description 1
- 239000001336 FEMA 3807 Substances 0.000 description 1
- 239000001116 FEMA 4028 Substances 0.000 description 1
- RZSYLLSAWYUBPE-UHFFFAOYSA-L Fast green FCF Chemical compound [Na+].[Na+].C=1C=C(C(=C2C=CC(C=C2)=[N+](CC)CC=2C=C(C=CC=2)S([O-])(=O)=O)C=2C(=CC(O)=CC=2)S([O-])(=O)=O)C=CC=1N(CC)CC1=CC=CC(S([O-])(=O)=O)=C1 RZSYLLSAWYUBPE-UHFFFAOYSA-L 0.000 description 1
- 206010016334 Feeling hot Diseases 0.000 description 1
- DKKCQDROTDCQOR-UHFFFAOYSA-L Ferrous lactate Chemical compound [Fe+2].CC(O)C([O-])=O.CC(O)C([O-])=O DKKCQDROTDCQOR-UHFFFAOYSA-L 0.000 description 1
- 235000007162 Ferula assa foetida Nutrition 0.000 description 1
- 244000228957 Ferula foetida Species 0.000 description 1
- 235000012850 Ferula foetida Nutrition 0.000 description 1
- 239000004606 Fillers/Extenders Substances 0.000 description 1
- CITFYDYEWQIEPX-UHFFFAOYSA-N Flavanol Natural products O1C2=CC(OCC=C(C)C)=CC(O)=C2C(=O)C(O)C1C1=CC=C(O)C=C1 CITFYDYEWQIEPX-UHFFFAOYSA-N 0.000 description 1
- JRHJXXLCNATYLS-NGZWBNMCSA-N Flavoxanthin Chemical compound C/C([C@H]1C=C2C(C)(C)C[C@H](O)C[C@@]2(C)O1)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\[C@H]1C(C)=C[C@H](O)CC1(C)C JRHJXXLCNATYLS-NGZWBNMCSA-N 0.000 description 1
- QHUMOJKEVAPSCY-JOJDNVQPSA-N Flavoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C1(C)OC2(C)CC(O)CC(C)(C)C2=C1)C=CC=C(/C)C=CC3C(=CC(O)CC3(C)C)C QHUMOJKEVAPSCY-JOJDNVQPSA-N 0.000 description 1
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
- 240000006927 Foeniculum vulgare Species 0.000 description 1
- 235000004204 Foeniculum vulgare Nutrition 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- 235000017048 Garcinia mangostana Nutrition 0.000 description 1
- 240000006053 Garcinia mangostana Species 0.000 description 1
- 240000001238 Gaultheria procumbens Species 0.000 description 1
- 235000007297 Gaultheria procumbens Nutrition 0.000 description 1
- 229920002148 Gellan gum Polymers 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 229920002581 Glucomannan Polymers 0.000 description 1
- 239000004366 Glucose oxidase Substances 0.000 description 1
- 108010015776 Glucose oxidase Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 108010024636 Glutathione Proteins 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- 239000004378 Glycyrrhizin Substances 0.000 description 1
- 235000001287 Guettarda speciosa Nutrition 0.000 description 1
- 239000001922 Gum ghatti Substances 0.000 description 1
- 229920000569 Gum karaya Polymers 0.000 description 1
- 239000000899 Gutta-Percha Substances 0.000 description 1
- 244000215562 Heliotropium arborescens Species 0.000 description 1
- 244000043261 Hevea brasiliensis Species 0.000 description 1
- 241001504226 Hoodia Species 0.000 description 1
- 241000735432 Hydrastis canadensis Species 0.000 description 1
- 229920001144 Hydroxy alpha sanshool Polymers 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- 208000037147 Hypercalcaemia Diseases 0.000 description 1
- 235000017309 Hypericum perforatum Nutrition 0.000 description 1
- 244000141009 Hypericum perforatum Species 0.000 description 1
- 208000013038 Hypocalcemia Diseases 0.000 description 1
- GRSZFWQUAKGDAV-KQYNXXCUSA-N IMP Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(O)=O)O[C@H]1N1C(NC=NC2=O)=C2N=C1 GRSZFWQUAKGDAV-KQYNXXCUSA-N 0.000 description 1
- 235000008227 Illicium verum Nutrition 0.000 description 1
- 240000007232 Illicium verum Species 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 239000009471 Ipecac Substances 0.000 description 1
- ODBLHEXUDAPZAU-FONMRSAGSA-N Isocitric acid Natural products OC(=O)[C@@H](O)[C@H](C(O)=O)CC(O)=O ODBLHEXUDAPZAU-FONMRSAGSA-N 0.000 description 1
- PWWVAXIEGOYWEE-UHFFFAOYSA-N Isophenergan Chemical compound C1=CC=C2N(CC(C)N(C)C)C3=CC=CC=C3SC2=C1 PWWVAXIEGOYWEE-UHFFFAOYSA-N 0.000 description 1
- GQODBWLKUWYOFX-UHFFFAOYSA-N Isorhamnetin Natural products C1=C(O)C(C)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 GQODBWLKUWYOFX-UHFFFAOYSA-N 0.000 description 1
- 235000010254 Jasminum officinale Nutrition 0.000 description 1
- 240000005385 Jasminum sambac Species 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- CKLJMWTZIZZHCS-UWTATZPHSA-N L-Aspartic acid Natural products OC(=O)[C@H](N)CC(O)=O CKLJMWTZIZZHCS-UWTATZPHSA-N 0.000 description 1
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 description 1
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 1
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 108010029541 Laccase Proteins 0.000 description 1
- 241000186660 Lactobacillus Species 0.000 description 1
- 240000001046 Lactobacillus acidophilus Species 0.000 description 1
- 235000013956 Lactobacillus acidophilus Nutrition 0.000 description 1
- 244000199866 Lactobacillus casei Species 0.000 description 1
- 235000013958 Lactobacillus casei Nutrition 0.000 description 1
- 241001134659 Lactobacillus curvatus Species 0.000 description 1
- 241000186840 Lactobacillus fermentum Species 0.000 description 1
- 240000006024 Lactobacillus plantarum Species 0.000 description 1
- 235000013965 Lactobacillus plantarum Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 240000000759 Lepidium meyenii Species 0.000 description 1
- 235000000421 Lepidium meyenii Nutrition 0.000 description 1
- 241000192130 Leuconostoc mesenteroides Species 0.000 description 1
- NNJVILVZKWQKPM-UHFFFAOYSA-N Lidocaine Chemical compound CCN(CC)CC(=O)NC1=C(C)C=CC=C1C NNJVILVZKWQKPM-UHFFFAOYSA-N 0.000 description 1
- 108090001060 Lipase Proteins 0.000 description 1
- 102000004882 Lipase Human genes 0.000 description 1
- 239000004367 Lipase Substances 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
- 239000004472 Lysine Substances 0.000 description 1
- SPAGIJMPHSUYSE-UHFFFAOYSA-N Magnesium peroxide Chemical compound [Mg+2].[O-][O-] SPAGIJMPHSUYSE-UHFFFAOYSA-N 0.000 description 1
- 241001673966 Magnolia officinalis Species 0.000 description 1
- 239000005913 Maltodextrin Substances 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- 241000220225 Malus Species 0.000 description 1
- 235000014826 Mangifera indica Nutrition 0.000 description 1
- 240000007228 Mangifera indica Species 0.000 description 1
- 240000002636 Manilkara bidentata Species 0.000 description 1
- 240000001794 Manilkara zapota Species 0.000 description 1
- 235000011339 Manilkara zapota Nutrition 0.000 description 1
- OCJYIGYOJCODJL-UHFFFAOYSA-N Meclizine Chemical compound CC1=CC=CC(CN2CCN(CC2)C(C=2C=CC=CC=2)C=2C=CC(Cl)=CC=2)=C1 OCJYIGYOJCODJL-UHFFFAOYSA-N 0.000 description 1
- MZSGWZGPESCJAN-MOBFUUNNSA-N Melitric acid A Natural products O([C@@H](C(=O)O)Cc1cc(O)c(O)cc1)C(=O)/C=C/c1cc(O)c(O/C(/C(=O)O)=C/c2cc(O)c(O)cc2)cc1 MZSGWZGPESCJAN-MOBFUUNNSA-N 0.000 description 1
- 235000014435 Mentha Nutrition 0.000 description 1
- 241001072983 Mentha Species 0.000 description 1
- LMXFTMYMHGYJEI-UHFFFAOYSA-N Menthoglycol Natural products CC1CCC(C(C)(C)O)C(O)C1 LMXFTMYMHGYJEI-UHFFFAOYSA-N 0.000 description 1
- ZBJCYZPANVLBRK-UHFFFAOYSA-N Menthone 1,2-glyceryl ketal Chemical compound CC(C)C1CCC(C)CC11OC(CO)CO1 ZBJCYZPANVLBRK-UHFFFAOYSA-N 0.000 description 1
- KNVPMEZIMFVWMD-UHFFFAOYSA-N Menthyl pyrrolidone carboxylate Chemical compound CC(C)C1CCC(C)CC1OC(=O)N1C(=O)CCC1 KNVPMEZIMFVWMD-UHFFFAOYSA-N 0.000 description 1
- 229920000168 Microcrystalline cellulose Polymers 0.000 description 1
- 235000005135 Micromeria juliana Nutrition 0.000 description 1
- 108010011756 Milk Proteins Proteins 0.000 description 1
- 102000014171 Milk Proteins Human genes 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 108050004114 Monellin Proteins 0.000 description 1
- 108010014251 Muramidase Proteins 0.000 description 1
- 102000016943 Muramidase Human genes 0.000 description 1
- 240000005561 Musa balbisiana Species 0.000 description 1
- 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
- 102000008934 Muscle Proteins Human genes 0.000 description 1
- 108010074084 Muscle Proteins Proteins 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- 108010062010 N-Acetylmuramoyl-L-alanine Amidase Proteins 0.000 description 1
- BLXXJMDCKKHMKV-UHFFFAOYSA-N Nabumetone Chemical compound C1=C(CCC(C)=O)C=CC2=CC(OC)=CC=C21 BLXXJMDCKKHMKV-UHFFFAOYSA-N 0.000 description 1
- CMWTZPSULFXXJA-UHFFFAOYSA-N Naproxen Natural products C1=C(C(C)C(O)=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-UHFFFAOYSA-N 0.000 description 1
- CWVRJTMFETXNAD-KLZCAUPSSA-N Neochlorogenin-saeure Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O CWVRJTMFETXNAD-KLZCAUPSSA-N 0.000 description 1
- JERYLJRGLVHIEW-UENHKZIGSA-N Norbixin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)C=CC=CC=CC(=O)O JERYLJRGLVHIEW-UENHKZIGSA-N 0.000 description 1
- RDPYCOMSZQUPGA-ILZVJNBOSA-N O.N[C@@H](CC(O)=O)C(=O)[C@@](N)(C)C(=O)NC1C(SC1(C)C)(C)C Chemical compound O.N[C@@H](CC(O)=O)C(=O)[C@@](N)(C)C(=O)NC1C(SC1(C)C)(C)C RDPYCOMSZQUPGA-ILZVJNBOSA-N 0.000 description 1
- SAIFVNITEPSVEV-JBLZRFIASA-N OC(=O)C[C@H](N)C(=O)C(C(O)CO)OC1=CC=CC=C1 Chemical compound OC(=O)C[C@H](N)C(=O)C(C(O)CO)OC1=CC=CC=C1 SAIFVNITEPSVEV-JBLZRFIASA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 description 1
- 240000000342 Palaquium gutta Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 240000004371 Panax ginseng Species 0.000 description 1
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 1
- 235000003140 Panax quinquefolius Nutrition 0.000 description 1
- 241001495453 Parthenium argentatum Species 0.000 description 1
- 235000000556 Paullinia cupana Nutrition 0.000 description 1
- 240000003444 Paullinia cupana Species 0.000 description 1
- LRBQNJMCXXYXIU-PPKXGCFTSA-N Penta-digallate-beta-D-glucose Natural products OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@@H]2[C@H]([C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-PPKXGCFTSA-N 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- MFOCDFTXLCYLKU-CMPLNLGQSA-N Phendimetrazine Chemical compound O1CCN(C)[C@@H](C)[C@@H]1C1=CC=CC=C1 MFOCDFTXLCYLKU-CMPLNLGQSA-N 0.000 description 1
- ISFHAYSTHMVOJR-UHFFFAOYSA-N Phenindamine Chemical compound C1N(C)CCC(C2=CC=CC=C22)=C1C2C1=CC=CC=C1 ISFHAYSTHMVOJR-UHFFFAOYSA-N 0.000 description 1
- OOUTWVMJGMVRQF-DOYZGLONSA-N Phoenicoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)C(=O)C(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)C(=O)CCC2(C)C OOUTWVMJGMVRQF-DOYZGLONSA-N 0.000 description 1
- 108010001441 Phosphopeptides Proteins 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000016787 Piper methysticum Nutrition 0.000 description 1
- 240000005546 Piper methysticum Species 0.000 description 1
- 244000203593 Piper nigrum Species 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 108010064851 Plant Proteins Proteins 0.000 description 1
- 235000011751 Pogostemon cablin Nutrition 0.000 description 1
- 240000002505 Pogostemon cablin Species 0.000 description 1
- 229920001100 Polydextrose Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920000388 Polyphosphate Polymers 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 235000016551 Potentilla erecta Nutrition 0.000 description 1
- 240000000103 Potentilla erecta Species 0.000 description 1
- 241000241413 Propolis Species 0.000 description 1
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 108010009736 Protein Hydrolysates Proteins 0.000 description 1
- 235000003893 Prunus dulcis var amara Nutrition 0.000 description 1
- 235000011158 Prunus mume Nutrition 0.000 description 1
- 244000018795 Prunus mume Species 0.000 description 1
- 235000006040 Prunus persica var persica Nutrition 0.000 description 1
- UVMRYBDEERADNV-UHFFFAOYSA-N Pseudoeugenol Natural products COC1=CC(C(C)=C)=CC=C1O UVMRYBDEERADNV-UHFFFAOYSA-N 0.000 description 1
- WTARULDDTDQWMU-UHFFFAOYSA-N Pseudopinene Natural products C1C2C(C)(C)C1CCC2=C WTARULDDTDQWMU-UHFFFAOYSA-N 0.000 description 1
- 244000294611 Punica granatum Species 0.000 description 1
- 235000014360 Punica granatum Nutrition 0.000 description 1
- 235000014443 Pyrus communis Nutrition 0.000 description 1
- 240000001987 Pyrus communis Species 0.000 description 1
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 1
- AAWZDTNXLSGCEK-ZHQZDSKASA-N Quinic acid Natural products O[C@H]1CC(O)(C(O)=O)C[C@H](O)C1O AAWZDTNXLSGCEK-ZHQZDSKASA-N 0.000 description 1
- QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 description 1
- VWXMLZQUDPCJPL-ZDHAIZATSA-N Rhodoxanthin Chemical compound CC\1=CC(=O)CC(C)(C)C/1=C\C=C(/C)\C=C\C=C(/C)\C=C\C=C\C(\C)=C\C=C\C(\C)=C\C=C1\C(C)=CC(=O)CC1(C)C VWXMLZQUDPCJPL-ZDHAIZATSA-N 0.000 description 1
- VWXMLZQUDPCJPL-XPZLFLLQSA-N Rhodoxanthin Natural products O=C1C=C(C)/C(=C\C=C(/C=C/C=C(\C=C\C=C\C(=C/C=C/C(=C\C=C\2/C(C)=CC(=O)CC/2(C)C)/C)\C)/C)\C)/C(C)(C)C1 VWXMLZQUDPCJPL-XPZLFLLQSA-N 0.000 description 1
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 1
- 241000220317 Rosa Species 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 241000288961 Saguinus imperator Species 0.000 description 1
- PSKIOIDCXFHNJA-UHFFFAOYSA-N Sanshool Natural products CC=CC=CC=CCCC=CC=CC(=O)NC(C)C PSKIOIDCXFHNJA-UHFFFAOYSA-N 0.000 description 1
- 235000007315 Satureja hortensis Nutrition 0.000 description 1
- 240000002114 Satureja hortensis Species 0.000 description 1
- FOIXSVOLVBLSDH-UHFFFAOYSA-N Silver ion Chemical compound [Ag+] FOIXSVOLVBLSDH-UHFFFAOYSA-N 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical class [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- BCKXLBQYZLBQEK-KVVVOXFISA-M Sodium oleate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC([O-])=O BCKXLBQYZLBQEK-KVVVOXFISA-M 0.000 description 1
- 239000004902 Softening Agent Substances 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000009184 Spondias indica Nutrition 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- 241000934878 Sterculia Species 0.000 description 1
- 244000057717 Streptococcus lactis Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 239000002174 Styrene-butadiene Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 1
- 239000000219 Sympatholytic Substances 0.000 description 1
- 241000736851 Tagetes Species 0.000 description 1
- 235000012308 Tagetes Nutrition 0.000 description 1
- 240000000785 Tagetes erecta Species 0.000 description 1
- 235000012311 Tagetes erecta Nutrition 0.000 description 1
- 235000003595 Tagetes minuta Nutrition 0.000 description 1
- 102000006463 Talin Human genes 0.000 description 1
- 108010083809 Talin Proteins 0.000 description 1
- IECRXMSGDFIOEY-UHFFFAOYSA-N Tangeretin Natural products COC=1C(OC)=C(OC)C(OC)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C=C1 IECRXMSGDFIOEY-UHFFFAOYSA-N 0.000 description 1
- GUGOEEXESWIERI-UHFFFAOYSA-N Terfenadine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 GUGOEEXESWIERI-UHFFFAOYSA-N 0.000 description 1
- 101710135233 Thaumatin I Proteins 0.000 description 1
- 101710135323 Thaumatin II Proteins 0.000 description 1
- 235000006468 Thea sinensis Nutrition 0.000 description 1
- 244000299461 Theobroma cacao Species 0.000 description 1
- 235000009470 Theobroma cacao Nutrition 0.000 description 1
- 229910021626 Tin(II) chloride Inorganic materials 0.000 description 1
- LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- UFLGIAIHIAPJJC-UHFFFAOYSA-N Tripelennamine Chemical compound C=1C=CC=NC=1N(CCN(C)C)CC1=CC=CC=C1 UFLGIAIHIAPJJC-UHFFFAOYSA-N 0.000 description 1
- 240000000359 Triticum dicoccon Species 0.000 description 1
- 235000012545 Vaccinium macrocarpon Nutrition 0.000 description 1
- 244000291414 Vaccinium oxycoccus Species 0.000 description 1
- 235000002118 Vaccinium oxycoccus Nutrition 0.000 description 1
- 239000004213 Violaxanthin Substances 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 108010046377 Whey Proteins Proteins 0.000 description 1
- 102000007544 Whey Proteins Human genes 0.000 description 1
- 229920002000 Xyloglucan Polymers 0.000 description 1
- JKQXZKUSFCKOGQ-LQFQNGICSA-N Z-zeaxanthin Natural products C([C@H](O)CC=1C)C(C)(C)C=1C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)C[C@@H](O)CC1(C)C JKQXZKUSFCKOGQ-LQFQNGICSA-N 0.000 description 1
- 241001078984 Zanthoxylum americanum Species 0.000 description 1
- QOPRSMDTRDMBNK-RNUUUQFGSA-N Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCC(O)C1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C QOPRSMDTRDMBNK-RNUUUQFGSA-N 0.000 description 1
- 229920002494 Zein Polymers 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 235000006886 Zingiber officinale Nutrition 0.000 description 1
- 244000273928 Zingiber officinale Species 0.000 description 1
- MKWSZTVOJKTLPX-HZSPNIEDSA-N [(1r,2s,5r)-2-isopropyl-5-methyl-cyclohexyl] 4-(dimethylamino)-4-oxo-butanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(=O)N(C)C MKWSZTVOJKTLPX-HZSPNIEDSA-N 0.000 description 1
- UJNOLBSYLSYIBM-WISYIIOYSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] (2r)-2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)[C@@H](C)O UJNOLBSYLSYIBM-WISYIIOYSA-N 0.000 description 1
- UJNOLBSYLSYIBM-SGUBAKSOSA-N [(1r,2s,5r)-5-methyl-2-propan-2-ylcyclohexyl] 2-hydroxypropanoate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C(C)O UJNOLBSYLSYIBM-SGUBAKSOSA-N 0.000 description 1
- JUIUXBHZFNHITF-IEOSBIPESA-N [(2r)-2,5,7,8-tetramethyl-2-[(4r,8r)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-yl] dihydrogen phosphate Chemical compound OP(=O)(O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C JUIUXBHZFNHITF-IEOSBIPESA-N 0.000 description 1
- OQWKEEOHDMUXEO-BQYQJAHWSA-N [6]-Shogaol Chemical compound CCCCC\C=C\C(=O)CCC1=CC=C(O)C(OC)=C1 OQWKEEOHDMUXEO-BQYQJAHWSA-N 0.000 description 1
- YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
- QFYJRROWSOMHGM-UHFFFAOYSA-L [Zn+2].[O-]S(=O)(=O)S([O-])(=O)=O Chemical compound [Zn+2].[O-]S(=O)(=O)S([O-])(=O)=O QFYJRROWSOMHGM-UHFFFAOYSA-L 0.000 description 1
- 239000003082 abrasive agent Substances 0.000 description 1
- DHKHKXVYLBGOIT-UHFFFAOYSA-N acetaldehyde Diethyl Acetal Natural products CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 1
- ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical compound [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 description 1
- 206010000496 acne Diseases 0.000 description 1
- 229960003792 acrivastine Drugs 0.000 description 1
- PWACSDKDOHSSQD-IUTFFREVSA-N acrivastine Chemical compound C1=CC(C)=CC=C1C(\C=1N=C(\C=C\C(O)=O)C=CC=1)=C/CN1CCCC1 PWACSDKDOHSSQD-IUTFFREVSA-N 0.000 description 1
- UDMBCSSLTHHNCD-KQYNXXCUSA-N adenosine 5'-monophosphate Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O UDMBCSSLTHHNCD-KQYNXXCUSA-N 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 235000010419 agar Nutrition 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 230000001476 alcoholic effect Effects 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- IAJILQKETJEXLJ-RSJOWCBRSA-N aldehydo-D-galacturonic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-RSJOWCBRSA-N 0.000 description 1
- IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical compound O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
- 150000001335 aliphatic alkanes Chemical class 0.000 description 1
- 235000019409 alitame Nutrition 0.000 description 1
- 108010009985 alitame Proteins 0.000 description 1
- 229930013930 alkaloid Natural products 0.000 description 1
- 150000008055 alkyl aryl sulfonates Chemical class 0.000 description 1
- 150000005215 alkyl ethers Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- 150000008051 alkyl sulfates Chemical class 0.000 description 1
- ZVKOASAVGLETCT-UOAMSCJGSA-N all-trans norbixin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C(=O)O)C=CC=C(/C)C=CC(=O)O ZVKOASAVGLETCT-UOAMSCJGSA-N 0.000 description 1
- JKQXZKUSFCKOGQ-LOFNIBRQSA-N all-trans-Zeaxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2=C(C)CC(O)CC2(C)C JKQXZKUSFCKOGQ-LOFNIBRQSA-N 0.000 description 1
- NBZANZVJRKXVBH-ITUXNECMSA-N all-trans-alpha-cryptoxanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC2C(=CCCC2(C)C)C NBZANZVJRKXVBH-ITUXNECMSA-N 0.000 description 1
- HZVVJJIYJKGMFL-UHFFFAOYSA-N almasilate Chemical compound O.[Mg+2].[Al+3].[Al+3].O[Si](O)=O.O[Si](O)=O HZVVJJIYJKGMFL-UHFFFAOYSA-N 0.000 description 1
- 235000011399 aloe vera Nutrition 0.000 description 1
- WQZGKKKJIJFFOK-PHYPRBDBSA-N alpha-D-galactose Chemical compound OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@H]1O WQZGKKKJIJFFOK-PHYPRBDBSA-N 0.000 description 1
- XCPQUQHBVVXMRQ-UHFFFAOYSA-N alpha-Fenchene Natural products C1CC2C(=C)CC1C2(C)C XCPQUQHBVVXMRQ-UHFFFAOYSA-N 0.000 description 1
- RAFGELQLHMBRHD-UHFFFAOYSA-N alpha-Fuc-(1-2)-beta-Gal-(1-3)-(beta-GlcNAc-(1-6))-GalNAc-ol Natural products COC(=O)C=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC(O)=O RAFGELQLHMBRHD-UHFFFAOYSA-N 0.000 description 1
- SBXYHCVXUCYYJT-UEOYEZOQSA-N alpha-Sanshool Chemical compound C\C=C\C=C\C=C/CC\C=C\C(=O)NCC(C)C SBXYHCVXUCYYJT-UEOYEZOQSA-N 0.000 description 1
- 239000011795 alpha-carotene Substances 0.000 description 1
- 235000003903 alpha-carotene Nutrition 0.000 description 1
- ANVAOWXLWRTKGA-HLLMEWEMSA-N alpha-carotene Natural products C(=C\C=C\C=C(/C=C/C=C(\C=C\C=1C(C)(C)CCCC=1C)/C)\C)(\C=C\C=C(/C=C/[C@H]1C(C)=CCCC1(C)C)\C)/C ANVAOWXLWRTKGA-HLLMEWEMSA-N 0.000 description 1
- AKNNEGZIBPJZJG-UHFFFAOYSA-N alpha-noscapine Natural products CN1CCC2=CC=3OCOC=3C(OC)=C2C1C1C2=CC=C(OC)C(OC)=C2C(=O)O1 AKNNEGZIBPJZJG-UHFFFAOYSA-N 0.000 description 1
- QQQCWVDPMPFUGF-ZDUSSCGKSA-N alpinetin Chemical compound C1([C@H]2OC=3C=C(O)C=C(C=3C(=O)C2)OC)=CC=CC=C1 QQQCWVDPMPFUGF-ZDUSSCGKSA-N 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000004645 aluminates Chemical class 0.000 description 1
- BWZOPYPOZJBVLQ-UHFFFAOYSA-K aluminium glycinate Chemical compound O[Al+]O.NCC([O-])=O BWZOPYPOZJBVLQ-UHFFFAOYSA-K 0.000 description 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 229940024545 aluminum hydroxide Drugs 0.000 description 1
- 229940009859 aluminum phosphate Drugs 0.000 description 1
- JIFPTBLGXRKRAO-UHFFFAOYSA-K aluminum;magnesium;hydroxide;sulfate Chemical compound [OH-].[Mg+2].[Al+3].[O-]S([O-])(=O)=O JIFPTBLGXRKRAO-UHFFFAOYSA-K 0.000 description 1
- SEIGJEJVIMIXIU-UHFFFAOYSA-J aluminum;sodium;carbonate;dihydroxide Chemical compound [Na+].O[Al+]O.[O-]C([O-])=O SEIGJEJVIMIXIU-UHFFFAOYSA-J 0.000 description 1
- 229960005174 ambroxol Drugs 0.000 description 1
- JBDGDEWWOUBZPM-XYPYZODXSA-N ambroxol Chemical compound NC1=C(Br)C=C(Br)C=C1CN[C@@H]1CC[C@@H](O)CC1 JBDGDEWWOUBZPM-XYPYZODXSA-N 0.000 description 1
- 235000019270 ammonium chloride Nutrition 0.000 description 1
- 229960001040 ammonium chloride Drugs 0.000 description 1
- 235000019418 amylase Nutrition 0.000 description 1
- 230000001195 anabolic effect Effects 0.000 description 1
- 230000000202 analgesic effect Effects 0.000 description 1
- 229940011037 anethole Drugs 0.000 description 1
- 239000003945 anionic surfactant Substances 0.000 description 1
- 239000010617 anise oil Substances 0.000 description 1
- 229940105969 annatto extract Drugs 0.000 description 1
- 239000005557 antagonist Substances 0.000 description 1
- 230000003288 anthiarrhythmic effect Effects 0.000 description 1
- 230000007131 anti Alzheimer effect Effects 0.000 description 1
- 239000004004 anti-anginal agent Substances 0.000 description 1
- 230000002272 anti-calculus Effects 0.000 description 1
- 230000002484 anti-cholesterolemic effect Effects 0.000 description 1
- 230000003561 anti-manic effect Effects 0.000 description 1
- 230000002460 anti-migrenic effect Effects 0.000 description 1
- 239000000883 anti-obesity agent Substances 0.000 description 1
- 230000000561 anti-psychotic effect Effects 0.000 description 1
- 230000002921 anti-spasmodic effect Effects 0.000 description 1
- 230000000320 anti-stroke effect Effects 0.000 description 1
- 229940088710 antibiotic agent Drugs 0.000 description 1
- 239000003146 anticoagulant agent Substances 0.000 description 1
- 229940127219 anticoagulant drug Drugs 0.000 description 1
- 229940125708 antidiabetic agent Drugs 0.000 description 1
- 229940125714 antidiarrheal agent Drugs 0.000 description 1
- 239000003793 antidiarrheal agent Substances 0.000 description 1
- 239000000729 antidote Substances 0.000 description 1
- 229940075522 antidotes Drugs 0.000 description 1
- 229960005475 antiinfective agent Drugs 0.000 description 1
- 239000000228 antimanic agent Substances 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 239000000939 antiparkinson agent Substances 0.000 description 1
- 239000003435 antirheumatic agent Substances 0.000 description 1
- 229940124575 antispasmodic agent Drugs 0.000 description 1
- 229940127217 antithrombotic drug Drugs 0.000 description 1
- 239000003699 antiulcer agent Substances 0.000 description 1
- 230000000949 anxiolytic effect Effects 0.000 description 1
- 229940005530 anxiolytics Drugs 0.000 description 1
- KZNIFHPLKGYRTM-UHFFFAOYSA-N apigenin Chemical compound C1=CC(O)=CC=C1C1=CC(=O)C2=C(O)C=C(O)C=C2O1 KZNIFHPLKGYRTM-UHFFFAOYSA-N 0.000 description 1
- XADJWCRESPGUTB-UHFFFAOYSA-N apigenin Natural products C1=CC(O)=CC=C1C1=CC(=O)C2=CC(O)=C(O)C=C2O1 XADJWCRESPGUTB-UHFFFAOYSA-N 0.000 description 1
- 235000008714 apigenin Nutrition 0.000 description 1
- 229940117893 apigenin Drugs 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 239000002948 appetite stimulant Substances 0.000 description 1
- 229940029995 appetite stimulants Drugs 0.000 description 1
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 1
- 239000007961 artificial flavoring substance Substances 0.000 description 1
- 229960004754 astemizole Drugs 0.000 description 1
- 239000000305 astragalus gummifer gum Substances 0.000 description 1
- 229960000383 azatadine Drugs 0.000 description 1
- SEBMTIQKRHYNIT-UHFFFAOYSA-N azatadine Chemical compound C1CN(C)CCC1=C1C2=NC=CC=C2CCC2=CC=CC=C21 SEBMTIQKRHYNIT-UHFFFAOYSA-N 0.000 description 1
- TVWOWDDBXAFQDG-DQRAZIAOSA-N azorubine Chemical compound C1=CC=C2C(\N=N/C3=C(C4=CC=CC=C4C(=C3)S(O)(=O)=O)O)=CC=C(S(O)(=O)=O)C2=C1 TVWOWDDBXAFQDG-DQRAZIAOSA-N 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 235000016302 balata Nutrition 0.000 description 1
- 239000010620 bay oil Substances 0.000 description 1
- 235000015278 beef Nutrition 0.000 description 1
- YNKMHABLMGIIFX-UHFFFAOYSA-N benzaldehyde;methane Chemical compound C.O=CC1=CC=CC=C1 YNKMHABLMGIIFX-UHFFFAOYSA-N 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- YXKTVDFXDRQTKV-HNNXBMFYSA-N benzphetamine Chemical compound C([C@H](C)N(C)CC=1C=CC=CC=1)C1=CC=CC=C1 YXKTVDFXDRQTKV-HNNXBMFYSA-N 0.000 description 1
- 229960002837 benzphetamine Drugs 0.000 description 1
- ANFSNXAXVLRZCG-RSAXXLAASA-N benzphetamine hydrochloride Chemical compound [Cl-].C([C@H](C)[NH+](C)CC=1C=CC=CC=1)C1=CC=CC=C1 ANFSNXAXVLRZCG-RSAXXLAASA-N 0.000 description 1
- FFBHFFJDDLITSX-UHFFFAOYSA-N benzyl N-[2-hydroxy-4-(3-oxomorpholin-4-yl)phenyl]carbamate Chemical compound OC1=C(NC(=O)OCC2=CC=CC=C2)C=CC(=C1)N1CCOCC1=O FFBHFFJDDLITSX-UHFFFAOYSA-N 0.000 description 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 description 1
- 235000013735 beta-apo-8'-carotenal Nutrition 0.000 description 1
- 239000001652 beta-apo-8'-carotenal Substances 0.000 description 1
- DFMMVLFMMAQXHZ-UHFFFAOYSA-N beta-apo-8-carotenal Chemical compound O=CC(C)=CC=CC(C)=CC=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C DFMMVLFMMAQXHZ-UHFFFAOYSA-N 0.000 description 1
- JGQFVRIQXUFPAH-UHFFFAOYSA-N beta-citronellol Natural products OCCC(C)CCCC(C)=C JGQFVRIQXUFPAH-UHFFFAOYSA-N 0.000 description 1
- 239000011774 beta-cryptoxanthin Substances 0.000 description 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 description 1
- 229930006722 beta-pinene Natural products 0.000 description 1
- 229960004853 betadex Drugs 0.000 description 1
- 235000002185 betanin Nutrition 0.000 description 1
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
- YZXZAUAIVAZWFN-UHFFFAOYSA-N bis(5-methyl-2-propan-2-ylcyclohexyl) butanedioate Chemical compound CC(C)C1CCC(C)CC1OC(=O)CCC(=O)OC1C(C(C)C)CCC(C)C1 YZXZAUAIVAZWFN-UHFFFAOYSA-N 0.000 description 1
- 229910052797 bismuth Inorganic materials 0.000 description 1
- 229940104825 bismuth aluminate Drugs 0.000 description 1
- JCXGWMGPZLAOME-UHFFFAOYSA-N bismuth atom Chemical compound [Bi] JCXGWMGPZLAOME-UHFFFAOYSA-N 0.000 description 1
- 229940036348 bismuth carbonate Drugs 0.000 description 1
- MGLUJXPJRXTKJM-UHFFFAOYSA-L bismuth subcarbonate Chemical compound O=[Bi]OC(=O)O[Bi]=O MGLUJXPJRXTKJM-UHFFFAOYSA-L 0.000 description 1
- 229940036358 bismuth subcarbonate Drugs 0.000 description 1
- JAONZGLTYYUPCT-UHFFFAOYSA-K bismuth subgallate Chemical compound OC(=O)C1=CC(O)=C2O[Bi](O)OC2=C1 JAONZGLTYYUPCT-UHFFFAOYSA-K 0.000 description 1
- 229960000199 bismuth subgallate Drugs 0.000 description 1
- 229960001482 bismuth subnitrate Drugs 0.000 description 1
- 235000019481 bixa orellana extract Nutrition 0.000 description 1
- RAFGELQLHMBRHD-SLEZCNMESA-N bixin Chemical compound COC(=O)\C=C\C(\C)=C/C=C/C(/C)=C/C=C/C=C(\C)/C=C/C=C(\C)/C=C/C(O)=O RAFGELQLHMBRHD-SLEZCNMESA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000004097 bone metabolism Effects 0.000 description 1
- 229940116229 borneol Drugs 0.000 description 1
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 description 1
- 229940115397 bornyl acetate Drugs 0.000 description 1
- 235000013532 brandy Nutrition 0.000 description 1
- 229960003870 bromhexine Drugs 0.000 description 1
- OJGDCBLYJGHCIH-UHFFFAOYSA-N bromhexine Chemical compound C1CCCCC1N(C)CC1=CC(Br)=CC(Br)=C1N OJGDCBLYJGHCIH-UHFFFAOYSA-N 0.000 description 1
- OZVBMTJYIDMWIL-AYFBDAFISA-N bromocriptine Chemical compound C1=CC(C=2[C@H](N(C)C[C@@H](C=2)C(=O)N[C@]2(C(=O)N3[C@H](C(N4CCC[C@H]4[C@]3(O)O2)=O)CC(C)C)C(C)C)C2)=C3C2=C(Br)NC3=C1 OZVBMTJYIDMWIL-AYFBDAFISA-N 0.000 description 1
- 229960002802 bromocriptine Drugs 0.000 description 1
- ZDIGNSYAACHWNL-UHFFFAOYSA-N brompheniramine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Br)C=C1 ZDIGNSYAACHWNL-UHFFFAOYSA-N 0.000 description 1
- 229960000725 brompheniramine Drugs 0.000 description 1
- 229940124630 bronchodilator Drugs 0.000 description 1
- 239000000168 bronchodilator agent Substances 0.000 description 1
- 239000006172 buffering agent Substances 0.000 description 1
- 235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
- YYRMJZQKEFZXMX-UHFFFAOYSA-L calcium bis(dihydrogenphosphate) Chemical compound [Ca+2].OP(O)([O-])=O.OP(O)([O-])=O YYRMJZQKEFZXMX-UHFFFAOYSA-L 0.000 description 1
- 239000001110 calcium chloride Substances 0.000 description 1
- 229910001628 calcium chloride Inorganic materials 0.000 description 1
- 235000011148 calcium chloride Nutrition 0.000 description 1
- LHJQIRIGXXHNLA-UHFFFAOYSA-N calcium peroxide Chemical compound [Ca+2].[O-][O-] LHJQIRIGXXHNLA-UHFFFAOYSA-N 0.000 description 1
- 235000019402 calcium peroxide Nutrition 0.000 description 1
- 229940095672 calcium sulfate Drugs 0.000 description 1
- 235000011132 calcium sulphate Nutrition 0.000 description 1
- MQRKKLAGBPVXCD-UHFFFAOYSA-L calcium;1,1-dioxo-1,2-benzothiazol-2-id-3-one;hydrate Chemical class O.[Ca+2].C1=CC=C2C([O-])=NS(=O)(=O)C2=C1.C1=CC=C2C([O-])=NS(=O)(=O)C2=C1 MQRKKLAGBPVXCD-UHFFFAOYSA-L 0.000 description 1
- 229960000846 camphor Drugs 0.000 description 1
- 229930008380 camphor Natural products 0.000 description 1
- 239000004204 candelilla wax Substances 0.000 description 1
- 235000013868 candelilla wax Nutrition 0.000 description 1
- 229940073532 candelilla wax Drugs 0.000 description 1
- 235000012682 canthaxanthin Nutrition 0.000 description 1
- 239000001659 canthaxanthin Substances 0.000 description 1
- 229940008033 canthaxanthin Drugs 0.000 description 1
- 235000018889 capsanthin Nutrition 0.000 description 1
- WRANYHFEXGNSND-LOFNIBRQSA-N capsanthin Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CC(O)CC1(C)C)C=CC=C(/C)C=CC(=O)C2(C)CCC(O)C2(C)C WRANYHFEXGNSND-LOFNIBRQSA-N 0.000 description 1
- 239000001511 capsicum annuum Substances 0.000 description 1
- 239000001325 capsicum annuum l. var. longum oleoresin Substances 0.000 description 1
- 239000001728 capsicum frutescens Substances 0.000 description 1
- 239000001722 capsicum frutescens oleoresin Substances 0.000 description 1
- 239000001390 capsicum minimum Substances 0.000 description 1
- 229940050948 capsicum oleoresin Drugs 0.000 description 1
- 235000013736 caramel Nutrition 0.000 description 1
- 239000004202 carbamide Substances 0.000 description 1
- 229940078916 carbamide peroxide Drugs 0.000 description 1
- 235000014633 carbohydrates Nutrition 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 239000006229 carbon black Substances 0.000 description 1
- 239000001569 carbon dioxide Substances 0.000 description 1
- 229910002092 carbon dioxide Inorganic materials 0.000 description 1
- 239000003575 carbonaceous material Substances 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical class OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 description 1
- 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
- 229940105329 carboxymethylcellulose Drugs 0.000 description 1
- 239000002327 cardiovascular agent Substances 0.000 description 1
- 229940125692 cardiovascular agent Drugs 0.000 description 1
- 239000004106 carminic acid Substances 0.000 description 1
- DGQLVPJVXFOQEV-JNVSTXMASA-N carminic acid Chemical compound OC1=C2C(=O)C=3C(C)=C(C(O)=O)C(O)=CC=3C(=O)C2=C(O)C(O)=C1[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O DGQLVPJVXFOQEV-JNVSTXMASA-N 0.000 description 1
- 229940031019 carmoisine Drugs 0.000 description 1
- 150000001746 carotenes Chemical class 0.000 description 1
- 235000005473 carotenes Nutrition 0.000 description 1
- 235000021466 carotenoid Nutrition 0.000 description 1
- 150000001747 carotenoids Chemical class 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000013709 carrot oil Nutrition 0.000 description 1
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 description 1
- 235000007746 carvacrol Nutrition 0.000 description 1
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 description 1
- 108010067454 caseinomacropeptide Proteins 0.000 description 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 description 1
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 description 1
- 235000005487 catechin Nutrition 0.000 description 1
- 229940119201 cedar leaf oil Drugs 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 229940041750 cesamet Drugs 0.000 description 1
- 229960001803 cetirizine Drugs 0.000 description 1
- 239000002738 chelating agent Chemical class 0.000 description 1
- JYNBEDVXQNFTOX-UHFFFAOYSA-N chembl2008134 Chemical compound OS(=O)(=O)C1=CC(C)=CC=C1N=NC1=C(O)C(C(O)=O)=CC2=CC=CC=C12 JYNBEDVXQNFTOX-UHFFFAOYSA-N 0.000 description 1
- 229940020114 chlophedianol hydrochloride Drugs 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 235000017168 chlorine Nutrition 0.000 description 1
- 235000019398 chlorine dioxide Nutrition 0.000 description 1
- 229940074393 chlorogenic acid Drugs 0.000 description 1
- CWVRJTMFETXNAD-JUHZACGLSA-N chlorogenic acid Chemical compound O[C@@H]1[C@H](O)C[C@@](O)(C(O)=O)C[C@H]1OC(=O)\C=C\C1=CC=C(O)C(O)=C1 CWVRJTMFETXNAD-JUHZACGLSA-N 0.000 description 1
- 235000001368 chlorogenic acid Nutrition 0.000 description 1
- FFQSDFBBSXGVKF-KHSQJDLVSA-N chlorogenic acid Natural products O[C@@H]1C[C@](O)(C[C@@H](CC(=O)C=Cc2ccc(O)c(O)c2)[C@@H]1O)C(=O)O FFQSDFBBSXGVKF-KHSQJDLVSA-N 0.000 description 1
- 235000012698 chlorophylls and chlorophyllins Nutrition 0.000 description 1
- 239000001752 chlorophylls and chlorophyllins Substances 0.000 description 1
- SOYKEARSMXGVTM-UHFFFAOYSA-N chlorphenamine Chemical compound C=1C=CC=NC=1C(CCN(C)C)C1=CC=C(Cl)C=C1 SOYKEARSMXGVTM-UHFFFAOYSA-N 0.000 description 1
- 229960003291 chlorphenamine Drugs 0.000 description 1
- 229950007046 chlorphentermine Drugs 0.000 description 1
- 239000008370 chocolate flavor Substances 0.000 description 1
- 239000000812 cholinergic antagonist Substances 0.000 description 1
- 239000000544 cholinesterase inhibitor Substances 0.000 description 1
- 229950001002 cianidanol Drugs 0.000 description 1
- 229960001380 cimetidine Drugs 0.000 description 1
- CCGSUNCLSOWKJO-UHFFFAOYSA-N cimetidine Chemical compound N#CNC(=N/C)\NCCSCC1=NC=N[C]1C CCGSUNCLSOWKJO-UHFFFAOYSA-N 0.000 description 1
- 235000005301 cimicifuga racemosa Nutrition 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- WJSDHUCWMSHDCR-VMPITWQZSA-N cinnamyl acetate Natural products CC(=O)OC\C=C\C1=CC=CC=C1 WJSDHUCWMSHDCR-VMPITWQZSA-N 0.000 description 1
- BMRSEYFENKXDIS-KLZCAUPSSA-N cis-3-O-p-coumaroylquinic acid Natural products O[C@H]1C[C@@](O)(C[C@@H](OC(=O)C=Cc2ccc(O)cc2)[C@@H]1O)C(=O)O BMRSEYFENKXDIS-KLZCAUPSSA-N 0.000 description 1
- XFTRTWQBIOMVPK-UHFFFAOYSA-N citramalic acid Chemical compound OC(=O)C(O)(C)CC(O)=O XFTRTWQBIOMVPK-UHFFFAOYSA-N 0.000 description 1
- 229930003633 citronellal Natural products 0.000 description 1
- 235000000983 citronellal Nutrition 0.000 description 1
- 235000000484 citronellol Nutrition 0.000 description 1
- 239000010500 citrus oil Substances 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 229960002881 clemastine Drugs 0.000 description 1
- YNNUSGIPVFPVBX-NHCUHLMSSA-N clemastine Chemical compound CN1CCC[C@@H]1CCO[C@@](C)(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 YNNUSGIPVFPVBX-NHCUHLMSSA-N 0.000 description 1
- 239000010634 clove oil Substances 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- FDJOLVPMNUYSCM-UVKKECPRSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2,7, Chemical compound [Co+3].N#[C-].C1([C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)[N-]\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O FDJOLVPMNUYSCM-UVKKECPRSA-L 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 229960004415 codeine phosphate Drugs 0.000 description 1
- 229960003871 codeine sulfate Drugs 0.000 description 1
- 239000005515 coenzyme Substances 0.000 description 1
- 229920001436 collagen Polymers 0.000 description 1
- 229920002770 condensed tannin Polymers 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 229940124558 contraceptive agent Drugs 0.000 description 1
- 239000003433 contraceptive agent Substances 0.000 description 1
- 239000004121 copper complexes of chlorophylls and chlorophyllins Substances 0.000 description 1
- 235000012700 copper complexes of chlorophylls and chlorophyllins Nutrition 0.000 description 1
- XTVVROIMIGLXTD-UHFFFAOYSA-N copper(II) nitrate Chemical compound [Cu+2].[O-][N+]([O-])=O.[O-][N+]([O-])=O XTVVROIMIGLXTD-UHFFFAOYSA-N 0.000 description 1
- HWDGVJUIHRPKFR-UHFFFAOYSA-I copper;trisodium;18-(2-carboxylatoethyl)-20-(carboxylatomethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18-dihydroporphyrin-21,23-diide-2-carboxylate Chemical compound [Na+].[Na+].[Na+].[Cu+2].N1=C(C(CC([O-])=O)=C2C(C(C)C(C=C3C(=C(C=C)C(=C4)[N-]3)C)=N2)CCC([O-])=O)C(=C([O-])[O-])C(C)=C1C=C1C(CC)=C(C)C4=N1 HWDGVJUIHRPKFR-UHFFFAOYSA-I 0.000 description 1
- 235000013712 corn endosperm oil Nutrition 0.000 description 1
- 239000003218 coronary vasodilator agent Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 235000004634 cranberry Nutrition 0.000 description 1
- 235000019244 cryptoxanthin Nutrition 0.000 description 1
- 235000003373 curcuma longa Nutrition 0.000 description 1
- 239000001081 curcuma longa l. root oleoresin Substances 0.000 description 1
- 235000019316 curdlan Nutrition 0.000 description 1
- 229940078035 curdlan Drugs 0.000 description 1
- YVWBQGFBSVLPIK-UHFFFAOYSA-N cyclohex-2-ene-1-carboxylic acid Chemical compound OC(=O)C1CCCC=C1 YVWBQGFBSVLPIK-UHFFFAOYSA-N 0.000 description 1
- 229960001140 cyproheptadine Drugs 0.000 description 1
- JJCFRYNCJDLXIK-UHFFFAOYSA-N cyproheptadine Chemical compound C1CN(C)CCC1=C1C2=CC=CC=C2C=CC2=CC=CC=C21 JJCFRYNCJDLXIK-UHFFFAOYSA-N 0.000 description 1
- 235000007240 daidzein Nutrition 0.000 description 1
- 230000000593 degrading effect Effects 0.000 description 1
- 235000007242 delphinidin Nutrition 0.000 description 1
- FFNDMZIBVDSQFI-UHFFFAOYSA-N delphinidin chloride Chemical compound [Cl-].[O+]=1C2=CC(O)=CC(O)=C2C=C(O)C=1C1=CC(O)=C(O)C(O)=C1 FFNDMZIBVDSQFI-UHFFFAOYSA-N 0.000 description 1
- 210000003298 dental enamel Anatomy 0.000 description 1
- 239000003975 dentin desensitizing agent Substances 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 229960001378 dequalinium chloride Drugs 0.000 description 1
- LTNZEXKYNRNOGT-UHFFFAOYSA-N dequalinium chloride Chemical compound [Cl-].[Cl-].C1=CC=C2[N+](CCCCCCCCCC[N+]3=C4C=CC=CC4=C(N)C=C3C)=C(C)C=C(N)C2=C1 LTNZEXKYNRNOGT-UHFFFAOYSA-N 0.000 description 1
- ZDIGNSYAACHWNL-HNNXBMFYSA-N dexbrompheniramine Chemical compound C1([C@H](CCN(C)C)C=2N=CC=CC=2)=CC=C(Br)C=C1 ZDIGNSYAACHWNL-HNNXBMFYSA-N 0.000 description 1
- 229960002691 dexbrompheniramine Drugs 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 229960003782 dextromethorphan hydrobromide Drugs 0.000 description 1
- JAQUASYNZVUNQP-PVAVHDDUSA-N dextrorphan Chemical compound C1C2=CC=C(O)C=C2[C@@]23CCN(C)[C@@H]1[C@H]2CCCC3 JAQUASYNZVUNQP-PVAVHDDUSA-N 0.000 description 1
- 229950006878 dextrorphan Drugs 0.000 description 1
- TXGQALXWGNPMKD-UHFFFAOYSA-L diazanium;zinc;disulfate;hexahydrate Chemical compound [NH4+].[NH4+].O.O.O.O.O.O.[Zn+2].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O TXGQALXWGNPMKD-UHFFFAOYSA-L 0.000 description 1
- GMZOPRQQINFLPQ-UHFFFAOYSA-H dibismuth;tricarbonate Chemical compound [Bi+3].[Bi+3].[O-]C([O-])=O.[O-]C([O-])=O.[O-]C([O-])=O GMZOPRQQINFLPQ-UHFFFAOYSA-H 0.000 description 1
- 229960001259 diclofenac Drugs 0.000 description 1
- DCOPUUMXTXDBNB-UHFFFAOYSA-N diclofenac Chemical compound OC(=O)CC1=CC=CC=C1NC1=C(Cl)C=CC=C1Cl DCOPUUMXTXDBNB-UHFFFAOYSA-N 0.000 description 1
- 229940120144 didrex Drugs 0.000 description 1
- 229960004890 diethylpropion Drugs 0.000 description 1
- XXEPPPIWZFICOJ-UHFFFAOYSA-N diethylpropion Chemical compound CCN(CC)C(C)C(=O)C1=CC=CC=C1 XXEPPPIWZFICOJ-UHFFFAOYSA-N 0.000 description 1
- 229960000616 diflunisal Drugs 0.000 description 1
- HUPFGZXOMWLGNK-UHFFFAOYSA-N diflunisal Chemical compound C1=C(O)C(C(=O)O)=CC(C=2C(=CC(F)=CC=2)F)=C1 HUPFGZXOMWLGNK-UHFFFAOYSA-N 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- XJQPQKLURWNAAH-UHFFFAOYSA-N dihydrocapsaicin Chemical compound COC1=CC(CNC(=O)CCCCCCC(C)C)=CC=C1O XJQPQKLURWNAAH-UHFFFAOYSA-N 0.000 description 1
- RBCYRZPENADQGZ-UHFFFAOYSA-N dihydrocapsaicin Natural products COC1=CC(COC(=O)CCCCCCC(C)C)=CC=C1O RBCYRZPENADQGZ-UHFFFAOYSA-N 0.000 description 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 description 1
- 229940015826 dihydroxyaluminum aminoacetate Drugs 0.000 description 1
- 229940015828 dihydroxyaluminum sodium carbonate Drugs 0.000 description 1
- GXGAKHNRMVGRPK-UHFFFAOYSA-N dimagnesium;dioxido-bis[[oxido(oxo)silyl]oxy]silane Chemical compound [Mg+2].[Mg+2].[O-][Si](=O)O[Si]([O-])([O-])O[Si]([O-])=O GXGAKHNRMVGRPK-UHFFFAOYSA-N 0.000 description 1
- MZDOIJOUFRQXHC-UHFFFAOYSA-N dimenhydrinate Chemical compound O=C1N(C)C(=O)N(C)C2=NC(Cl)=N[C]21.C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 MZDOIJOUFRQXHC-UHFFFAOYSA-N 0.000 description 1
- 229960004993 dimenhydrinate Drugs 0.000 description 1
- LRCFXGAMWKDGLA-UHFFFAOYSA-N dioxosilane;hydrate Chemical compound O.O=[Si]=O LRCFXGAMWKDGLA-UHFFFAOYSA-N 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- ZZVUWRFHKOJYTH-UHFFFAOYSA-N diphenhydramine Chemical compound C=1C=CC=CC=1C(OCCN(C)C)C1=CC=CC=C1 ZZVUWRFHKOJYTH-UHFFFAOYSA-N 0.000 description 1
- 229960001583 diphenhydramine citrate Drugs 0.000 description 1
- 229960000525 diphenhydramine hydrochloride Drugs 0.000 description 1
- 235000019820 disodium diphosphate Nutrition 0.000 description 1
- 235000013890 disodium inosinate Nutrition 0.000 description 1
- 239000004194 disodium inosinate Substances 0.000 description 1
- GYQBBRRVRKFJRG-UHFFFAOYSA-L disodium pyrophosphate Chemical compound [Na+].[Na+].OP([O-])(=O)OP(O)([O-])=O GYQBBRRVRKFJRG-UHFFFAOYSA-L 0.000 description 1
- YSVBPNGJESBVRM-UHFFFAOYSA-L disodium;4-[(1-oxido-4-sulfonaphthalen-2-yl)diazenyl]naphthalene-1-sulfonate Chemical compound [Na+].[Na+].C1=CC=C2C(N=NC3=C(C4=CC=CC=C4C(=C3)S([O-])(=O)=O)O)=CC=C(S([O-])(=O)=O)C2=C1 YSVBPNGJESBVRM-UHFFFAOYSA-L 0.000 description 1
- UMGSFZGNYYDQSL-UHFFFAOYSA-H disodium;tin(4+);hexafluoride Chemical compound [F-].[F-].[F-].[F-].[F-].[F-].[Na+].[Na+].[Sn+4] UMGSFZGNYYDQSL-UHFFFAOYSA-H 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 239000002934 diuretic Substances 0.000 description 1
- 229940030606 diuretics Drugs 0.000 description 1
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 description 1
- DLNKOYKMWOXYQA-UHFFFAOYSA-N dl-pseudophenylpropanolamine Natural products CC(N)C(O)C1=CC=CC=C1 DLNKOYKMWOXYQA-UHFFFAOYSA-N 0.000 description 1
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical class CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 1
- GVGUFUZHNYFZLC-UHFFFAOYSA-N dodecyl benzenesulfonate;sodium Chemical compound [Na].CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 GVGUFUZHNYFZLC-UHFFFAOYSA-N 0.000 description 1
- 229960001859 domiphen bromide Drugs 0.000 description 1
- 239000003136 dopamine receptor stimulating agent Substances 0.000 description 1
- 229960005178 doxylamine Drugs 0.000 description 1
- HCFDWZZGGLSKEP-UHFFFAOYSA-N doxylamine Chemical compound C=1C=CC=NC=1C(C)(OCCN(C)C)C1=CC=CC=C1 HCFDWZZGGLSKEP-UHFFFAOYSA-N 0.000 description 1
- 235000013760 dried algae meal Nutrition 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229960000385 dyclonine Drugs 0.000 description 1
- BZEWSEKUUPWQDQ-UHFFFAOYSA-N dyclonine Chemical compound C1=CC(OCCCC)=CC=C1C(=O)CCN1CCCCC1 BZEWSEKUUPWQDQ-UHFFFAOYSA-N 0.000 description 1
- KNZADIMHVBBPOA-UHFFFAOYSA-N dyclonine hydrochloride Chemical compound [Cl-].C1=CC(OCCCC)=CC=C1C(=O)CC[NH+]1CCCCC1 KNZADIMHVBBPOA-UHFFFAOYSA-N 0.000 description 1
- 229960003462 dyclonine hydrochloride Drugs 0.000 description 1
- 229960001971 ebastine Drugs 0.000 description 1
- MJJALKDDGIKVBE-UHFFFAOYSA-N ebastine Chemical compound C1=CC(C(C)(C)C)=CC=C1C(=O)CCCN1CCC(OC(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 MJJALKDDGIKVBE-UHFFFAOYSA-N 0.000 description 1
- ZQHFZHPUZXNPMF-UHFFFAOYSA-N ebrotidine Chemical compound S1C(N=C(N)N)=NC(CSCCN=CNS(=O)(=O)C=2C=CC(Br)=CC=2)=C1 ZQHFZHPUZXNPMF-UHFFFAOYSA-N 0.000 description 1
- 229950002377 ebrotidine Drugs 0.000 description 1
- 230000002196 ecbolic effect Effects 0.000 description 1
- 235000014134 echinacea Nutrition 0.000 description 1
- 235000020694 echinacea extract Nutrition 0.000 description 1
- 238000005265 energy consumption Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 description 1
- 235000012734 epicatechin Nutrition 0.000 description 1
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 description 1
- SBHXYTNGIZCORC-ZDUSSCGKSA-N eriodictyol Chemical compound C1([C@@H]2CC(=O)C3=C(O)C=C(C=C3O2)O)=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-ZDUSSCGKSA-N 0.000 description 1
- TUJPOVKMHCLXEL-UHFFFAOYSA-N eriodictyol Natural products C1C(=O)C2=CC(O)=CC(O)=C2OC1C1=CC=C(O)C(O)=C1 TUJPOVKMHCLXEL-UHFFFAOYSA-N 0.000 description 1
- 235000011797 eriodictyol Nutrition 0.000 description 1
- SBHXYTNGIZCORC-UHFFFAOYSA-N eriodyctiol Natural products O1C2=CC(O)=CC(O)=C2C(=O)CC1C1=CC=C(O)C(O)=C1 SBHXYTNGIZCORC-UHFFFAOYSA-N 0.000 description 1
- 230000000913 erythropoietic effect Effects 0.000 description 1
- IINNWAYUJNWZRM-UHFFFAOYSA-L erythrosin B Chemical compound [Na+].[Na+].[O-]C(=O)C1=CC=CC=C1C1=C2C=C(I)C(=O)C(I)=C2OC2=C(I)C([O-])=C(I)C=C21 IINNWAYUJNWZRM-UHFFFAOYSA-L 0.000 description 1
- 229940011411 erythrosine Drugs 0.000 description 1
- 150000002169 ethanolamines Chemical class 0.000 description 1
- MFGZXPGKKJMZIY-UHFFFAOYSA-N ethyl 5-amino-1-(4-sulfamoylphenyl)pyrazole-4-carboxylate Chemical compound NC1=C(C(=O)OCC)C=NN1C1=CC=C(S(N)(=O)=O)C=C1 MFGZXPGKKJMZIY-UHFFFAOYSA-N 0.000 description 1
- 235000019325 ethyl cellulose Nutrition 0.000 description 1
- 229920001249 ethyl cellulose Polymers 0.000 description 1
- 125000004494 ethyl ester group Chemical group 0.000 description 1
- 229960005293 etodolac Drugs 0.000 description 1
- XFBVBWWRPKNWHW-UHFFFAOYSA-N etodolac Chemical compound C1COC(CC)(CC(O)=O)C2=N[C]3C(CC)=CC=CC3=C21 XFBVBWWRPKNWHW-UHFFFAOYSA-N 0.000 description 1
- 229940007062 eucalyptus extract Drugs 0.000 description 1
- 229960002217 eugenol Drugs 0.000 description 1
- 108010079553 euphauserase Proteins 0.000 description 1
- 235000008524 evening primrose extract Nutrition 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 108010000165 exo-1,3-alpha-glucanase Proteins 0.000 description 1
- 210000000416 exudates and transudate Anatomy 0.000 description 1
- 229960001596 famotidine Drugs 0.000 description 1
- XUFQPHANEAPEMJ-UHFFFAOYSA-N famotidine Chemical compound NC(N)=NC1=NC(CSCCC(N)=NS(N)(=O)=O)=CS1 XUFQPHANEAPEMJ-UHFFFAOYSA-N 0.000 description 1
- 229960001419 fenoprofen Drugs 0.000 description 1
- 235000013924 ferrous gluconate Nutrition 0.000 description 1
- 239000004222 ferrous gluconate Substances 0.000 description 1
- 229960001645 ferrous gluconate Drugs 0.000 description 1
- 235000013925 ferrous lactate Nutrition 0.000 description 1
- 239000004225 ferrous lactate Substances 0.000 description 1
- 229940037907 ferrous lactate Drugs 0.000 description 1
- 239000002871 fertility agent Substances 0.000 description 1
- 229960003592 fexofenadine Drugs 0.000 description 1
- RWTNPBWLLIMQHL-UHFFFAOYSA-N fexofenadine Chemical compound C1=CC(C(C)(C(O)=O)C)=CC=C1C(O)CCCN1CCC(C(O)(C=2C=CC=CC=2)C=2C=CC=CC=2)CC1 RWTNPBWLLIMQHL-UHFFFAOYSA-N 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 229940013317 fish oils Drugs 0.000 description 1
- 150000002206 flavan-3-ols Chemical class 0.000 description 1
- 125000004387 flavanoid group Chemical group 0.000 description 1
- 235000011987 flavanols Nutrition 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 150000002215 flavonoids Chemical class 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
- 150000002216 flavonol derivatives Chemical class 0.000 description 1
- 235000011957 flavonols Nutrition 0.000 description 1
- 239000005454 flavour additive Substances 0.000 description 1
- NWKFECICNXDNOQ-UHFFFAOYSA-N flavylium Chemical compound C1=CC=CC=C1C1=CC=C(C=CC=C2)C2=[O+]1 NWKFECICNXDNOQ-UHFFFAOYSA-N 0.000 description 1
- 150000004673 fluoride salts Chemical class 0.000 description 1
- OMRRUNXAWXNVFW-UHFFFAOYSA-N fluoridochlorine Chemical compound ClF OMRRUNXAWXNVFW-UHFFFAOYSA-N 0.000 description 1
- 229960002390 flurbiprofen Drugs 0.000 description 1
- SYTBZMRGLBWNTM-UHFFFAOYSA-N flurbiprofen Chemical compound FC1=CC(C(C(O)=O)C)=CC=C1C1=CC=CC=C1 SYTBZMRGLBWNTM-UHFFFAOYSA-N 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000002864 food coloring agent Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- FBPFZTCFMRRESA-GUCUJZIJSA-N galactitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-GUCUJZIJSA-N 0.000 description 1
- 229930182830 galactose Natural products 0.000 description 1
- LRBQNJMCXXYXIU-QWKBTXIPSA-N gallotannic acid Chemical compound OC1=C(O)C(O)=CC(C(=O)OC=2C(=C(O)C=C(C=2)C(=O)OC[C@H]2[C@@H]([C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)[C@@H](OC(=O)C=3C=C(OC(=O)C=4C=C(O)C(O)=C(O)C=4)C(O)=C(O)C=3)O2)OC(=O)C=2C=C(OC(=O)C=3C=C(O)C(O)=C(O)C=3)C(O)=C(O)C=2)O)=C1 LRBQNJMCXXYXIU-QWKBTXIPSA-N 0.000 description 1
- LCWMKIHBLJLORW-UHFFFAOYSA-N gamma-carene Natural products C1CC(=C)CC2C(C)(C)C21 LCWMKIHBLJLORW-UHFFFAOYSA-N 0.000 description 1
- 239000011663 gamma-carotene Substances 0.000 description 1
- 235000000633 gamma-carotene Nutrition 0.000 description 1
- HRQKOYFGHJYEFS-RZWPOVEWSA-N gamma-carotene Natural products C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=1C(C)(C)CCCC=1C)\C)/C)\C)(\C=C\C=C(/CC/C=C(\C)/C)\C)/C HRQKOYFGHJYEFS-RZWPOVEWSA-N 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 239000004083 gastrointestinal agent Substances 0.000 description 1
- 229940125695 gastrointestinal agent Drugs 0.000 description 1
- 235000010492 gellan gum Nutrition 0.000 description 1
- 239000000216 gellan gum Substances 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 235000006539 genistein Nutrition 0.000 description 1
- 229940045109 genistein Drugs 0.000 description 1
- TZBJGXHYKVUXJN-UHFFFAOYSA-N genistein Natural products C1=CC(O)=CC=C1C1=COC2=CC(O)=CC(O)=C2C1=O TZBJGXHYKVUXJN-UHFFFAOYSA-N 0.000 description 1
- ZCOLJUOHXJRHDI-CMWLGVBASA-N genistein 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(C=3C=CC(O)=CC=3)=COC2=C1 ZCOLJUOHXJRHDI-CMWLGVBASA-N 0.000 description 1
- 235000008397 ginger Nutrition 0.000 description 1
- 235000008434 ginseng Nutrition 0.000 description 1
- 229940046240 glucomannan Drugs 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 235000019420 glucose oxidase Nutrition 0.000 description 1
- 229940116332 glucose oxidase Drugs 0.000 description 1
- 229940097043 glucuronic acid Drugs 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 150000002306 glutamic acid derivatives Chemical class 0.000 description 1
- 229960003180 glutathione Drugs 0.000 description 1
- 235000010985 glycerol esters of wood rosin Nutrition 0.000 description 1
- DXYUAIFZCFRPTH-UHFFFAOYSA-N glycitein Chemical compound C1=C(O)C(OC)=CC(C2=O)=C1OC=C2C1=CC=C(O)C=C1 DXYUAIFZCFRPTH-UHFFFAOYSA-N 0.000 description 1
- 235000008466 glycitein Nutrition 0.000 description 1
- NNUVCMKMNCKPKN-UHFFFAOYSA-N glycitein Natural products COc1c(O)ccc2OC=C(C(=O)c12)c3ccc(O)cc3 NNUVCMKMNCKPKN-UHFFFAOYSA-N 0.000 description 1
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 1
- 229960004949 glycyrrhizic acid Drugs 0.000 description 1
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 1
- 235000019410 glycyrrhizin Nutrition 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- PCHJSUWPFVWCPO-UHFFFAOYSA-N gold Chemical compound [Au] PCHJSUWPFVWCPO-UHFFFAOYSA-N 0.000 description 1
- 235000005679 goldenseal Nutrition 0.000 description 1
- 229940107702 grapefruit seed extract Drugs 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 229960002146 guaifenesin Drugs 0.000 description 1
- 235000019314 gum ghatti Nutrition 0.000 description 1
- 229920000588 gutta-percha Polymers 0.000 description 1
- 235000013763 haematococcus algae meal Nutrition 0.000 description 1
- IUJAMGNYPWYUPM-UHFFFAOYSA-N hentriacontane Chemical compound CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC IUJAMGNYPWYUPM-UHFFFAOYSA-N 0.000 description 1
- 235000008216 herbs Nutrition 0.000 description 1
- PDSAKIXGSONUIX-UHFFFAOYSA-N hexaaluminum;dibismuth;oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[O-2].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Bi+3].[Bi+3] PDSAKIXGSONUIX-UHFFFAOYSA-N 0.000 description 1
- 150000002402 hexoses Chemical class 0.000 description 1
- 229960003258 hexylresorcinol Drugs 0.000 description 1
- 239000000938 histamine H1 antagonist Substances 0.000 description 1
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 description 1
- 230000001632 homeopathic effect Effects 0.000 description 1
- MLJGZARGNROKAC-VQHVLOKHSA-N homocapsaicin Chemical compound CCC(C)\C=C\CCCCC(=O)NCC1=CC=C(O)C(OC)=C1 MLJGZARGNROKAC-VQHVLOKHSA-N 0.000 description 1
- JKIHLSTUOQHAFF-UHFFFAOYSA-N homocapsaicin Natural products COC1=CC(CNC(=O)CCCCCC=CC(C)C)=CC=C1O JKIHLSTUOQHAFF-UHFFFAOYSA-N 0.000 description 1
- JZNZUOZRIWOBGG-UHFFFAOYSA-N homocapsaicin-II Natural products COC1=CC(CNC(=O)CCCCC=CCC(C)C)=CC=C1O JZNZUOZRIWOBGG-UHFFFAOYSA-N 0.000 description 1
- GOBFKCLUUUDTQE-UHFFFAOYSA-N homodihydrocapsaicin-II Natural products CCC(C)CCCCCCC(=O)NCC1=CC=C(O)C(OC)=C1 GOBFKCLUUUDTQE-UHFFFAOYSA-N 0.000 description 1
- 235000012907 honey Nutrition 0.000 description 1
- 235000017277 hoodia Nutrition 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 230000036571 hydration Effects 0.000 description 1
- 238000006703 hydration reaction Methods 0.000 description 1
- BHEPBYXIRTUNPN-UHFFFAOYSA-N hydridophosphorus(.) (triplet) Chemical compound [PH] BHEPBYXIRTUNPN-UHFFFAOYSA-N 0.000 description 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 description 1
- 229960000240 hydrocodone Drugs 0.000 description 1
- 239000008173 hydrogenated soybean oil Substances 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- XSEOYPMPHHCUBN-FGYWBSQSSA-N hydroxylated lecithin Chemical class CCCCCCCCCCCCCCCCCC(=O)OC(COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCC[C@@H](O)[C@H](O)CCCCCCCC XSEOYPMPHHCUBN-FGYWBSQSSA-N 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
- 229960000930 hydroxyzine Drugs 0.000 description 1
- ZQDWXGKKHFNSQK-UHFFFAOYSA-N hydroxyzine Chemical compound C1CN(CCOCCO)CCN1C(C=1C=CC(Cl)=CC=1)C1=CC=CC=C1 ZQDWXGKKHFNSQK-UHFFFAOYSA-N 0.000 description 1
- 230000000148 hypercalcaemia Effects 0.000 description 1
- 208000030915 hypercalcemia disease Diseases 0.000 description 1
- 230000003345 hyperglycaemic effect Effects 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 230000000705 hypocalcaemia Effects 0.000 description 1
- 229940126904 hypoglycaemic agent Drugs 0.000 description 1
- 239000000367 immunologic factor Substances 0.000 description 1
- 239000002955 immunomodulating agent Substances 0.000 description 1
- 229940121354 immunomodulator Drugs 0.000 description 1
- 229940125721 immunosuppressive agent Drugs 0.000 description 1
- 201000001881 impotence Diseases 0.000 description 1
- 229940005632 indigotindisulfonic acid Drugs 0.000 description 1
- 239000004179 indigotine Substances 0.000 description 1
- 235000012738 indigotine Nutrition 0.000 description 1
- 229910001506 inorganic fluoride Inorganic materials 0.000 description 1
- 235000013902 inosinic acid Nutrition 0.000 description 1
- 238000012432 intermediate storage Methods 0.000 description 1
- 229960004903 invert sugar Drugs 0.000 description 1
- 239000003456 ion exchange resin Substances 0.000 description 1
- 229920003303 ion-exchange polymer Polymers 0.000 description 1
- 229940036543 ionamin Drugs 0.000 description 1
- 229940029408 ipecac Drugs 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- YOBAEOGBNPPUQV-UHFFFAOYSA-N iron;trihydrate Chemical compound O.O.O.[Fe].[Fe] YOBAEOGBNPPUQV-UHFFFAOYSA-N 0.000 description 1
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 1
- CJWQYWQDLBZGPD-UHFFFAOYSA-N isoflavone Natural products C1=C(OC)C(OC)=CC(OC)=C1C1=COC2=C(C=CC(C)(C)O3)C3=C(OC)C=C2C1=O CJWQYWQDLBZGPD-UHFFFAOYSA-N 0.000 description 1
- 150000002515 isoflavone derivatives Chemical class 0.000 description 1
- 235000008696 isoflavones Nutrition 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940039009 isoproterenol Drugs 0.000 description 1
- 229940095045 isopulegol Drugs 0.000 description 1
- IZQSVPBOUDKVDZ-UHFFFAOYSA-N isorhamnetin Chemical compound C1=C(O)C(OC)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 IZQSVPBOUDKVDZ-UHFFFAOYSA-N 0.000 description 1
- 235000008800 isorhamnetin Nutrition 0.000 description 1
- RCRODHONKLSMIF-UHFFFAOYSA-N isosuberenol Natural products O1C(=O)C=CC2=C1C=C(OC)C(CC(O)C(C)=C)=C2 RCRODHONKLSMIF-UHFFFAOYSA-N 0.000 description 1
- 239000000177 juniperus communis l. berry Substances 0.000 description 1
- 235000008777 kaempferol Nutrition 0.000 description 1
- 235000010494 karaya gum Nutrition 0.000 description 1
- 239000000231 karaya gum Substances 0.000 description 1
- 229940039371 karaya gum Drugs 0.000 description 1
- DKYWVDODHFEZIM-UHFFFAOYSA-N ketoprofen Chemical compound OC(=O)C(C)C1=CC=CC(C(=O)C=2C=CC=CC=2)=C1 DKYWVDODHFEZIM-UHFFFAOYSA-N 0.000 description 1
- 229960000991 ketoprofen Drugs 0.000 description 1
- 229960004752 ketorolac Drugs 0.000 description 1
- OZWKMVRBQXNZKK-UHFFFAOYSA-N ketorolac Chemical compound OC(=O)C1CCN2C1=CC=C2C(=O)C1=CC=CC=C1 OZWKMVRBQXNZKK-UHFFFAOYSA-N 0.000 description 1
- 238000004898 kneading Methods 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000252 konjac Substances 0.000 description 1
- 229940039696 lactobacillus Drugs 0.000 description 1
- 229940039695 lactobacillus acidophilus Drugs 0.000 description 1
- 229940017800 lactobacillus casei Drugs 0.000 description 1
- 229940012969 lactobacillus fermentum Drugs 0.000 description 1
- 229940072205 lactobacillus plantarum Drugs 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000008141 laxative Substances 0.000 description 1
- 229940125722 laxative agent Drugs 0.000 description 1
- 235000012902 lepidium meyenii Nutrition 0.000 description 1
- 229960004194 lidocaine Drugs 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 229940087305 limonene Drugs 0.000 description 1
- 235000001510 limonene Nutrition 0.000 description 1
- 229930007744 linalool Natural products 0.000 description 1
- 235000019421 lipase Nutrition 0.000 description 1
- 239000008374 liqueur flavor Substances 0.000 description 1
- 239000003589 local anesthetic agent Substances 0.000 description 1
- 229960005015 local anesthetics Drugs 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 229960003088 loratadine Drugs 0.000 description 1
- JCCNYMKQOSZNPW-UHFFFAOYSA-N loratadine Chemical compound C1CN(C(=O)OCC)CCC1=C1C2=NC=CC=C2CCC2=CC(Cl)=CC=C21 JCCNYMKQOSZNPW-UHFFFAOYSA-N 0.000 description 1
- IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
- LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
- 235000009498 luteolin Nutrition 0.000 description 1
- 235000010335 lysozyme Nutrition 0.000 description 1
- 239000004325 lysozyme Substances 0.000 description 1
- 229960000274 lysozyme Drugs 0.000 description 1
- 239000001115 mace Substances 0.000 description 1
- 235000021073 macronutrients Nutrition 0.000 description 1
- 229960004018 magaldrate Drugs 0.000 description 1
- 229910001629 magnesium chloride Inorganic materials 0.000 description 1
- 235000011147 magnesium chloride Nutrition 0.000 description 1
- 229940004916 magnesium glycinate Drugs 0.000 description 1
- 229960000816 magnesium hydroxide Drugs 0.000 description 1
- 239000000395 magnesium oxide Substances 0.000 description 1
- CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 1
- 229960000869 magnesium oxide Drugs 0.000 description 1
- 235000012245 magnesium oxide Nutrition 0.000 description 1
- 229960004995 magnesium peroxide Drugs 0.000 description 1
- 239000000391 magnesium silicate Substances 0.000 description 1
- 229940091250 magnesium supplement Drugs 0.000 description 1
- 235000019793 magnesium trisilicate Nutrition 0.000 description 1
- 229940099273 magnesium trisilicate Drugs 0.000 description 1
- 229910000386 magnesium trisilicate Inorganic materials 0.000 description 1
- AACACXATQSKRQG-UHFFFAOYSA-L magnesium;2-aminoacetate Chemical compound [Mg+2].NCC([O-])=O.NCC([O-])=O AACACXATQSKRQG-UHFFFAOYSA-L 0.000 description 1
- ZATZOOLBPDMARD-UHFFFAOYSA-N magnesium;hydrate Chemical compound O.[Mg] ZATZOOLBPDMARD-UHFFFAOYSA-N 0.000 description 1
- AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 1
- 229940035034 maltodextrin Drugs 0.000 description 1
- 235000009584 malvidin Nutrition 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229960001474 meclozine Drugs 0.000 description 1
- 239000001683 mentha spicata herb oil Substances 0.000 description 1
- SJOXEWUZWQYCGL-DVOMOZLQSA-N menthyl salicylate Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-DVOMOZLQSA-N 0.000 description 1
- 229960004665 menthyl salicylate Drugs 0.000 description 1
- 229960000582 mepyramine Drugs 0.000 description 1
- YECBIJXISLIIDS-UHFFFAOYSA-N mepyramine Chemical compound C1=CC(OC)=CC=C1CN(CCN(C)C)C1=CC=CC=N1 YECBIJXISLIIDS-UHFFFAOYSA-N 0.000 description 1
- TWXDDNPPQUTEOV-FVGYRXGTSA-N methamphetamine hydrochloride Chemical compound Cl.CN[C@@H](C)CC1=CC=CC=C1 TWXDDNPPQUTEOV-FVGYRXGTSA-N 0.000 description 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Substances OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 1
- BHQQXAOBIZQEGI-UHFFFAOYSA-N methyl 2-chlorobutanoate Chemical compound CCC(Cl)C(=O)OC BHQQXAOBIZQEGI-UHFFFAOYSA-N 0.000 description 1
- 229940016286 microcrystalline cellulose Drugs 0.000 description 1
- 235000019813 microcrystalline cellulose Nutrition 0.000 description 1
- 239000008108 microcrystalline cellulose Substances 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 229950008866 mifentidine Drugs 0.000 description 1
- 235000021239 milk protein Nutrition 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000014569 mints Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 239000003607 modifier Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 235000019691 monocalcium phosphate Nutrition 0.000 description 1
- 229910000150 monocalcium phosphate Inorganic materials 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 235000013919 monopotassium glutamate Nutrition 0.000 description 1
- 239000004239 monopotassium glutamate Substances 0.000 description 1
- 150000002772 monosaccharides Chemical class 0.000 description 1
- LPUQAYUQRXPFSQ-DFWYDOINSA-M monosodium L-glutamate Chemical compound [Na+].[O-]C(=O)[C@@H](N)CCC(O)=O LPUQAYUQRXPFSQ-DFWYDOINSA-M 0.000 description 1
- 235000013923 monosodium glutamate Nutrition 0.000 description 1
- 239000004223 monosodium glutamate Substances 0.000 description 1
- UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
- 201000003152 motion sickness Diseases 0.000 description 1
- 238000009740 moulding (composite fabrication) Methods 0.000 description 1
- 235000019575 mouthfulness Nutrition 0.000 description 1
- 229940035363 muscle relaxants Drugs 0.000 description 1
- 235000010460 mustard Nutrition 0.000 description 1
- 239000003158 myorelaxant agent Substances 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- GOZUADYOHPCXLE-UHFFFAOYSA-N n-[4-(1h-imidazol-5-yl)phenyl]-n'-propan-2-ylmethanimidamide Chemical compound C1=CC(NC=NC(C)C)=CC=C1C1=CN=CN1 GOZUADYOHPCXLE-UHFFFAOYSA-N 0.000 description 1
- ZVKDZYPEJXGLJG-UHFFFAOYSA-N n-tert-butyl-5-methyl-2-propan-2-ylcyclohexane-1-carboxamide Chemical compound CC(C)C1CCC(C)CC1C(=O)NC(C)(C)C ZVKDZYPEJXGLJG-UHFFFAOYSA-N 0.000 description 1
- 229960004270 nabumetone Drugs 0.000 description 1
- 229960002009 naproxen Drugs 0.000 description 1
- 229960003940 naproxen sodium Drugs 0.000 description 1
- CDBRNDSHEYLDJV-FVGYRXGTSA-M naproxen sodium Chemical compound [Na+].C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CDBRNDSHEYLDJV-FVGYRXGTSA-M 0.000 description 1
- CMWTZPSULFXXJA-VIFPVBQESA-M naproxen(1-) Chemical compound C1=C([C@H](C)C([O-])=O)C=CC2=CC(OC)=CC=C21 CMWTZPSULFXXJA-VIFPVBQESA-M 0.000 description 1
- PLPRGLOFPNJOTN-UHFFFAOYSA-N narcotine Natural products COc1ccc2C(OC(=O)c2c1OC)C3Cc4c(CN3C)cc5OCOc5c4OC PLPRGLOFPNJOTN-UHFFFAOYSA-N 0.000 description 1
- WGEYAGZBLYNDFV-UHFFFAOYSA-N naringenin Natural products C1(=O)C2=C(O)C=C(O)C=C2OC(C1)C1=CC=C(CC1)O WGEYAGZBLYNDFV-UHFFFAOYSA-N 0.000 description 1
- 235000007625 naringenin Nutrition 0.000 description 1
- 229940117954 naringenin Drugs 0.000 description 1
- 229920001206 natural gum Polymers 0.000 description 1
- 239000005445 natural material Substances 0.000 description 1
- 230000002232 neuromuscular Effects 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 description 1
- GYHFUZHODSMOHU-UHFFFAOYSA-N nonanal Chemical compound CCCCCCCCC=O GYHFUZHODSMOHU-UHFFFAOYSA-N 0.000 description 1
- 229960004708 noscapine Drugs 0.000 description 1
- 239000002773 nucleotide Substances 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- NUJGJRNETVAIRJ-UHFFFAOYSA-N octanal Chemical compound CCCCCCCC=O NUJGJRNETVAIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 235000020660 omega-3 fatty acid Nutrition 0.000 description 1
- 229940012843 omega-3 fatty acid Drugs 0.000 description 1
- 239000006014 omega-3 oil Substances 0.000 description 1
- 235000020333 oolong tea Nutrition 0.000 description 1
- 235000014366 other mixer Nutrition 0.000 description 1
- 229960002085 oxycodone Drugs 0.000 description 1
- 229960001528 oxymetazoline Drugs 0.000 description 1
- 239000002863 oxytocic agent Substances 0.000 description 1
- 229940094443 oxytocics prostaglandins Drugs 0.000 description 1
- ZRSNZINYAWTAHE-UHFFFAOYSA-N p-methoxybenzaldehyde Chemical compound COC1=CC=C(C=O)C=C1 ZRSNZINYAWTAHE-UHFFFAOYSA-N 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940098695 palmitic acid Drugs 0.000 description 1
- DYUUPIKEWLHQGQ-SDXBLLFJSA-N paprika oleoresin Chemical compound C(\[C@]12[C@@](O1)(C)C[C@@H](O)CC2(C)C)=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=C[C@H]1C(C)=C[C@H](O)CC1(C)C DYUUPIKEWLHQGQ-SDXBLLFJSA-N 0.000 description 1
- QNGNSVIICDLXHT-UHFFFAOYSA-N para-ethylbenzaldehyde Natural products CCC1=CC=C(C=O)C=C1 QNGNSVIICDLXHT-UHFFFAOYSA-N 0.000 description 1
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 1
- 230000002445 parasympatholytic effect Effects 0.000 description 1
- 239000000734 parasympathomimetic agent Substances 0.000 description 1
- 230000001499 parasympathomimetic effect Effects 0.000 description 1
- 229940005542 parasympathomimetics Drugs 0.000 description 1
- 235000012736 patent blue V Nutrition 0.000 description 1
- 239000004177 patent blue V Substances 0.000 description 1
- HKUHOPQRJKPJCJ-UHFFFAOYSA-N pelargonidin Natural products OC1=Cc2c(O)cc(O)cc2OC1c1ccc(O)cc1 HKUHOPQRJKPJCJ-UHFFFAOYSA-N 0.000 description 1
- 235000006251 pelargonidin Nutrition 0.000 description 1
- YPVZJXMTXCOTJN-UHFFFAOYSA-N pelargonidin chloride Chemical compound [Cl-].C1=CC(O)=CC=C1C(C(=C1)O)=[O+]C2=C1C(O)=CC(O)=C2 YPVZJXMTXCOTJN-UHFFFAOYSA-N 0.000 description 1
- QGWDKKHSDXWPET-UHFFFAOYSA-E pentabismuth;oxygen(2-);nonahydroxide;tetranitrate Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[O-2].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[Bi+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O QGWDKKHSDXWPET-UHFFFAOYSA-E 0.000 description 1
- WXZMFSXDPGVJKK-UHFFFAOYSA-N pentaerythritol Chemical class OCC(CO)(CO)CO WXZMFSXDPGVJKK-UHFFFAOYSA-N 0.000 description 1
- 229960003436 pentoxyverine Drugs 0.000 description 1
- 229930015721 peonidin Natural products 0.000 description 1
- 235000006404 peonidin Nutrition 0.000 description 1
- OGBSHLKSHNAPEW-UHFFFAOYSA-N peonidin chloride Chemical compound [Cl-].C1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O)=C1 OGBSHLKSHNAPEW-UHFFFAOYSA-N 0.000 description 1
- 239000007967 peppermint flavor Substances 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 230000000737 periodic effect Effects 0.000 description 1
- 239000000810 peripheral vasodilating agent Substances 0.000 description 1
- 229960002116 peripheral vasodilator Drugs 0.000 description 1
- 150000002978 peroxides Chemical class 0.000 description 1
- 239000003208 petroleum Substances 0.000 description 1
- 229930015717 petunidin Natural products 0.000 description 1
- 235000006384 petunidin Nutrition 0.000 description 1
- QULMBDNPZCFSPR-UHFFFAOYSA-N petunidin chloride Chemical compound [Cl-].OC1=C(O)C(OC)=CC(C=2C(=CC=3C(O)=CC(O)=CC=3[O+]=2)O)=C1 QULMBDNPZCFSPR-UHFFFAOYSA-N 0.000 description 1
- 235000013970 phaffia yeast Nutrition 0.000 description 1
- 229960000436 phendimetrazine Drugs 0.000 description 1
- 229960003534 phenindamine Drugs 0.000 description 1
- 229960003562 phentermine Drugs 0.000 description 1
- 229960001802 phenylephrine Drugs 0.000 description 1
- SONNWYBIRXJNDC-VIFPVBQESA-N phenylephrine Chemical compound CNC[C@H](O)C1=CC=CC(O)=C1 SONNWYBIRXJNDC-VIFPVBQESA-N 0.000 description 1
- XMGMFRIEKMMMSU-UHFFFAOYSA-N phenylmethylbenzene Chemical group C=1C=CC=CC=1[C]C1=CC=CC=C1 XMGMFRIEKMMMSU-UHFFFAOYSA-N 0.000 description 1
- DLNKOYKMWOXYQA-APPZFPTMSA-N phenylpropanolamine Chemical compound C[C@@H](N)[C@H](O)C1=CC=CC=C1 DLNKOYKMWOXYQA-APPZFPTMSA-N 0.000 description 1
- 229960000395 phenylpropanolamine Drugs 0.000 description 1
- 229960001526 phenyltoloxamine Drugs 0.000 description 1
- IZRPKIZLIFYYKR-UHFFFAOYSA-N phenyltoloxamine Chemical compound CN(C)CCOC1=CC=CC=C1CC1=CC=CC=C1 IZRPKIZLIFYYKR-UHFFFAOYSA-N 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 235000014786 phosphorus Nutrition 0.000 description 1
- 229940085127 phytase Drugs 0.000 description 1
- 239000003075 phytoestrogen Substances 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- PZTQVMXMKVTIRC-RZLHGTIFSA-L pigment rubine Chemical compound [Ca+2].[O-]S(=O)(=O)C1=CC(C)=CC=C1\N=N\C1=C(O)C(C([O-])=O)=CC2=CC=CC=C12 PZTQVMXMKVTIRC-RZLHGTIFSA-L 0.000 description 1
- 239000001894 piper nigrum l. oleoresin black Substances 0.000 description 1
- MXXWOMGUGJBKIW-YPCIICBESA-N piperine Chemical compound C=1C=C2OCOC2=CC=1/C=C/C=C/C(=O)N1CCCCC1 MXXWOMGUGJBKIW-YPCIICBESA-N 0.000 description 1
- WVWHRXVVAYXKDE-UHFFFAOYSA-N piperine Natural products O=C(C=CC=Cc1ccc2OCOc2c1)C3CCCCN3 WVWHRXVVAYXKDE-UHFFFAOYSA-N 0.000 description 1
- 235000019100 piperine Nutrition 0.000 description 1
- 229940075559 piperine Drugs 0.000 description 1
- 229940081310 piperonal Drugs 0.000 description 1
- 229960002702 piroxicam Drugs 0.000 description 1
- QYSPLQLAKJAUJT-UHFFFAOYSA-N piroxicam Chemical compound OC=1C2=CC=CC=C2S(=O)(=O)N(C)C=1C(=O)NC1=CC=CC=N1 QYSPLQLAKJAUJT-UHFFFAOYSA-N 0.000 description 1
- 229940124837 pisatidine Drugs 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 239000005014 poly(hydroxyalkanoate) Substances 0.000 description 1
- 229920003229 poly(methyl methacrylate) Polymers 0.000 description 1
- 235000013856 polydextrose Nutrition 0.000 description 1
- 239000001259 polydextrose Substances 0.000 description 1
- 229940035035 polydextrose Drugs 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000903 polyhydroxyalkanoate Polymers 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000001205 polyphosphate Substances 0.000 description 1
- 235000011176 polyphosphates Nutrition 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 229920002635 polyurethane Polymers 0.000 description 1
- 239000004814 polyurethane Substances 0.000 description 1
- 229920002744 polyvinyl acetate phthalate Polymers 0.000 description 1
- 229940100467 polyvinyl acetate phthalate Drugs 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000004175 ponceau 4R Substances 0.000 description 1
- 235000012731 ponceau 4R Nutrition 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 235000015497 potassium bicarbonate Nutrition 0.000 description 1
- 229910000028 potassium bicarbonate Inorganic materials 0.000 description 1
- 239000011736 potassium bicarbonate Substances 0.000 description 1
- 239000001508 potassium citrate Substances 0.000 description 1
- 229960002635 potassium citrate Drugs 0.000 description 1
- QEEAPRPFLLJWCF-UHFFFAOYSA-K potassium citrate (anhydrous) Chemical compound [K+].[K+].[K+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O QEEAPRPFLLJWCF-UHFFFAOYSA-K 0.000 description 1
- 235000011082 potassium citrates Nutrition 0.000 description 1
- TYJJADVDDVDEDZ-UHFFFAOYSA-M potassium hydrogencarbonate Chemical compound [K+].OC([O-])=O TYJJADVDDVDEDZ-UHFFFAOYSA-M 0.000 description 1
- 239000004323 potassium nitrate Substances 0.000 description 1
- 235000010333 potassium nitrate Nutrition 0.000 description 1
- 229940114930 potassium stearate Drugs 0.000 description 1
- HQEROMHPIOLGCB-DFWYDOINSA-M potassium;(2s)-2-aminopentanedioate;hydron Chemical compound [K+].[O-]C(=O)[C@@H](N)CCC(O)=O HQEROMHPIOLGCB-DFWYDOINSA-M 0.000 description 1
- ANBFRLKBEIFNQU-UHFFFAOYSA-M potassium;octadecanoate Chemical compound [K+].CCCCCCCCCCCCCCCCCC([O-])=O ANBFRLKBEIFNQU-UHFFFAOYSA-M 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 239000006041 probiotic Substances 0.000 description 1
- 235000018291 probiotics Nutrition 0.000 description 1
- 238000004886 process control Methods 0.000 description 1
- 229960003910 promethazine Drugs 0.000 description 1
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
- 239000000770 propane-1,2-diol alginate Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 229940069949 propolis Drugs 0.000 description 1
- 239000000473 propyl gallate Substances 0.000 description 1
- 235000010388 propyl gallate Nutrition 0.000 description 1
- 229940075579 propyl gallate Drugs 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 229940024999 proteolytic enzymes for treatment of wounds and ulcers Drugs 0.000 description 1
- 229960003908 pseudoephedrine Drugs 0.000 description 1
- KWGRBVOPPLSCSI-WCBMZHEXSA-N pseudoephedrine Chemical compound CN[C@@H](C)[C@@H](O)C1=CC=CC=C1 KWGRBVOPPLSCSI-WCBMZHEXSA-N 0.000 description 1
- 229940001470 psychoactive drug Drugs 0.000 description 1
- 239000004089 psychotropic agent Substances 0.000 description 1
- 230000000506 psychotropic effect Effects 0.000 description 1
- 238000005086 pumping Methods 0.000 description 1
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 235000005875 quercetin Nutrition 0.000 description 1
- 229960001285 quercetin Drugs 0.000 description 1
- 229940051201 quinoline yellow Drugs 0.000 description 1
- IZMJMCDDWKSTTK-UHFFFAOYSA-N quinoline yellow Chemical compound C1=CC=CC2=NC(C3C(C4=CC=CC=C4C3=O)=O)=CC=C21 IZMJMCDDWKSTTK-UHFFFAOYSA-N 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 229960001520 ranitidine hydrochloride Drugs 0.000 description 1
- GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 230000011514 reflex Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 235000021283 resveratrol Nutrition 0.000 description 1
- 229940016667 resveratrol Drugs 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 239000010668 rosemary oil Substances 0.000 description 1
- 229940058206 rosemary oil Drugs 0.000 description 1
- 229960003320 roxatidine Drugs 0.000 description 1
- 229960003287 roxatidine acetate Drugs 0.000 description 1
- 239000005060 rubber Substances 0.000 description 1
- 235000009514 rubixanthin Nutrition 0.000 description 1
- 239000000455 rubixanthin Substances 0.000 description 1
- ABTRFGSPYXCGMR-SDPRXREBSA-N rubixanthin Natural products O[C@H]1CC(C)(C)C(/C=C/C(=C\C=C\C(=C/C=C/C=C(\C=C\C=C(/C=C/C=C(\CC/C=C(\C)/C)/C)\C)/C)\C)/C)=C(C)C1 ABTRFGSPYXCGMR-SDPRXREBSA-N 0.000 description 1
- 235000019204 saccharin Nutrition 0.000 description 1
- 229940081974 saccharin Drugs 0.000 description 1
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 235000013974 saffron Nutrition 0.000 description 1
- 239000004248 saffron Substances 0.000 description 1
- CQRYARSYNCAZFO-UHFFFAOYSA-N salicyl alcohol Chemical compound OCC1=CC=CC=C1O CQRYARSYNCAZFO-UHFFFAOYSA-N 0.000 description 1
- SJOXEWUZWQYCGL-UHFFFAOYSA-N salicylic acid menthyl ester Natural products CC(C)C1CCC(C)CC1OC(=O)C1=CC=CC=C1O SJOXEWUZWQYCGL-UHFFFAOYSA-N 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 235000019608 salt taste sensations Nutrition 0.000 description 1
- 235000019600 saltiness Nutrition 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 238000010008 shearing Methods 0.000 description 1
- JXOHGGNKMLTUBP-HSUXUTPPSA-N shikimic acid Chemical compound O[C@@H]1CC(C(O)=O)=C[C@@H](O)[C@H]1O JXOHGGNKMLTUBP-HSUXUTPPSA-N 0.000 description 1
- JXOHGGNKMLTUBP-JKUQZMGJSA-N shikimic acid Natural products O[C@@H]1CC(C(O)=O)=C[C@H](O)[C@@H]1O JXOHGGNKMLTUBP-JKUQZMGJSA-N 0.000 description 1
- DEIYFTQMQPDXOT-UHFFFAOYSA-N sildenafil citrate Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O.CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 DEIYFTQMQPDXOT-UHFFFAOYSA-N 0.000 description 1
- 229960002639 sildenafil citrate Drugs 0.000 description 1
- 229960004029 silicic acid Drugs 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 229940107518 slippery elm bark Drugs 0.000 description 1
- 229940124535 smoking cessation aid Drugs 0.000 description 1
- HELHAJAZNSDZJO-OLXYHTOASA-L sodium L-tartrate Chemical compound [Na+].[Na+].[O-]C(=O)[C@H](O)[C@@H](O)C([O-])=O HELHAJAZNSDZJO-OLXYHTOASA-L 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- WBHQBSYUUJJSRZ-UHFFFAOYSA-M sodium bisulfate Chemical compound [Na+].OS([O-])(=O)=O WBHQBSYUUJJSRZ-UHFFFAOYSA-M 0.000 description 1
- 229910000342 sodium bisulfate Inorganic materials 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 235000013758 sodium copper chlorophyllin Nutrition 0.000 description 1
- 229940079841 sodium copper chlorophyllin Drugs 0.000 description 1
- FQENQNTWSFEDLI-UHFFFAOYSA-J sodium diphosphate Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P([O-])(=O)OP([O-])([O-])=O FQENQNTWSFEDLI-UHFFFAOYSA-J 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- 235000019982 sodium hexametaphosphate Nutrition 0.000 description 1
- GCLGEJMYGQKIIW-UHFFFAOYSA-H sodium hexametaphosphate Chemical compound [Na]OP1(=O)OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])OP(=O)(O[Na])O1 GCLGEJMYGQKIIW-UHFFFAOYSA-H 0.000 description 1
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 1
- PFUVRDFDKPNGAV-UHFFFAOYSA-N sodium peroxide Chemical compound [Na+].[Na+].[O-][O-] PFUVRDFDKPNGAV-UHFFFAOYSA-N 0.000 description 1
- IJRHDFLHUATAOS-DPMBMXLASA-M sodium ricinoleate Chemical compound [Na+].CCCCCC[C@@H](O)C\C=C/CCCCCCCC([O-])=O IJRHDFLHUATAOS-DPMBMXLASA-M 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 229940080350 sodium stearate Drugs 0.000 description 1
- 239000001433 sodium tartrate Substances 0.000 description 1
- 229960002167 sodium tartrate Drugs 0.000 description 1
- 235000011004 sodium tartrates Nutrition 0.000 description 1
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 1
- 239000002195 soluble material Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 235000003687 soy isoflavones Nutrition 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000019710 soybean protein Nutrition 0.000 description 1
- 235000019721 spearmint oil Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000001119 stannous chloride Substances 0.000 description 1
- 235000011150 stannous chloride Nutrition 0.000 description 1
- 230000003068 static effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 229960004274 stearic acid Drugs 0.000 description 1
- 235000019202 steviosides Nutrition 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- BAQAVOSOZGMPRM-UHFFFAOYSA-N sucralose Chemical compound OC1C(O)C(Cl)C(CO)OC1OC1(CCl)C(O)C(O)C(CCl)O1 BAQAVOSOZGMPRM-UHFFFAOYSA-N 0.000 description 1
- 229940124530 sulfonamide Drugs 0.000 description 1
- 150000003456 sulfonamides Chemical class 0.000 description 1
- 239000011593 sulfur Substances 0.000 description 1
- 229910052717 sulfur Inorganic materials 0.000 description 1
- 235000001508 sulfur Nutrition 0.000 description 1
- 230000000153 supplemental effect Effects 0.000 description 1
- 230000000948 sympatholitic effect Effects 0.000 description 1
- 235000013759 synthetic iron oxide Nutrition 0.000 description 1
- 239000007916 tablet composition Substances 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 229920002258 tannic acid Polymers 0.000 description 1
- 235000015523 tannic acid Nutrition 0.000 description 1
- 229940033123 tannic acid Drugs 0.000 description 1
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 1
- 229960000943 tartrazine Drugs 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- 229960000351 terfenadine Drugs 0.000 description 1
- 229930006978 terpinene Natural products 0.000 description 1
- 150000003507 terpinene derivatives Chemical class 0.000 description 1
- IMCGHZIGRANKHV-AJNGGQMLSA-N tert-butyl (3s,5s)-2-oxo-5-[(2s,4s)-5-oxo-4-propan-2-yloxolan-2-yl]-3-propan-2-ylpyrrolidine-1-carboxylate Chemical compound O1C(=O)[C@H](C(C)C)C[C@H]1[C@H]1N(C(=O)OC(C)(C)C)C(=O)[C@H](C(C)C)C1 IMCGHZIGRANKHV-AJNGGQMLSA-N 0.000 description 1
- 235000019818 tetrasodium diphosphate Nutrition 0.000 description 1
- 239000001577 tetrasodium phosphonato phosphate Substances 0.000 description 1
- 235000014620 theaflavin Nutrition 0.000 description 1
- 235000008118 thearubigins Nutrition 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- ODBLHEXUDAPZAU-UHFFFAOYSA-N threo-D-isocitric acid Natural products OC(=O)C(O)C(C(O)=O)CC(O)=O ODBLHEXUDAPZAU-UHFFFAOYSA-N 0.000 description 1
- 239000001789 thuja occidentalis l. leaf oil Substances 0.000 description 1
- 239000010678 thyme oil Substances 0.000 description 1
- 210000001685 thyroid gland Anatomy 0.000 description 1
- 229940043672 thyroid preparations Drugs 0.000 description 1
- YUOWTJMRMWQJDA-UHFFFAOYSA-J tin(iv) fluoride Chemical class [F-].[F-].[F-].[F-].[Sn+4] YUOWTJMRMWQJDA-UHFFFAOYSA-J 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 235000013755 toasted partially defatted cooked cottonseed flour Nutrition 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 125000002640 tocopherol group Chemical class 0.000 description 1
- 235000019149 tocopherols Nutrition 0.000 description 1
- 229930003802 tocotrienol Natural products 0.000 description 1
- 239000011731 tocotrienol Substances 0.000 description 1
- 235000019148 tocotrienols Nutrition 0.000 description 1
- 229940068778 tocotrienols Drugs 0.000 description 1
- 239000007852 tooth bleaching agent Substances 0.000 description 1
- 239000008377 tooth whitener Substances 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 239000003204 tranquilizing agent Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 210000003901 trigeminal nerve Anatomy 0.000 description 1
- 229960003223 tripelennamine Drugs 0.000 description 1
- AAAQKTZKLRYKHR-UHFFFAOYSA-N triphenylmethane Chemical compound C1=CC=CC=C1C(C=1C=CC=CC=1)C1=CC=CC=C1 AAAQKTZKLRYKHR-UHFFFAOYSA-N 0.000 description 1
- 229960001128 triprolidine Drugs 0.000 description 1
- CBEQULMOCCWAQT-WOJGMQOQSA-N triprolidine Chemical compound C1=CC(C)=CC=C1C(\C=1N=CC=CC=1)=C/CN1CCCC1 CBEQULMOCCWAQT-WOJGMQOQSA-N 0.000 description 1
- UJMBCXLDXJUMFB-UHFFFAOYSA-K trisodium;5-oxo-1-(4-sulfonatophenyl)-4-[(4-sulfonatophenyl)diazenyl]-4h-pyrazole-3-carboxylate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-UHFFFAOYSA-K 0.000 description 1
- 235000013976 turmeric Nutrition 0.000 description 1
- 235000013975 turmeric oleoresin Nutrition 0.000 description 1
- 235000013799 ultramarine blue Nutrition 0.000 description 1
- 235000019583 umami taste Nutrition 0.000 description 1
- AQLJVWUFPCUVLO-UHFFFAOYSA-N urea hydrogen peroxide Chemical compound OO.NC(N)=O AQLJVWUFPCUVLO-UHFFFAOYSA-N 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
- 239000002996 urinary tract agent Substances 0.000 description 1
- 239000008371 vanilla flavor Substances 0.000 description 1
- 229940117960 vanillin Drugs 0.000 description 1
- KOCVACNWDMSLBM-UHFFFAOYSA-N vanillyl alcohol ethyl ether Natural products CCOCC1=CC=C(O)C(OC)=C1 KOCVACNWDMSLBM-UHFFFAOYSA-N 0.000 description 1
- 239000005526 vasoconstrictor agent Substances 0.000 description 1
- 229940124549 vasodilator Drugs 0.000 description 1
- 239000003071 vasodilator agent Substances 0.000 description 1
- 239000004108 vegetable carbon Substances 0.000 description 1
- 235000012712 vegetable carbon Nutrition 0.000 description 1
- 235000015192 vegetable juice Nutrition 0.000 description 1
- 239000012178 vegetable wax Substances 0.000 description 1
- 235000019245 violaxanthin Nutrition 0.000 description 1
- 239000003190 viscoelastic substance Substances 0.000 description 1
- 239000011345 viscous material Substances 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019158 vitamin B6 Nutrition 0.000 description 1
- 239000011726 vitamin B6 Substances 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 229940045999 vitamin b 12 Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 229920003176 water-insoluble polymer Polymers 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 235000015041 whisky Nutrition 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
- 150000003735 xanthophylls Chemical class 0.000 description 1
- 235000008210 xanthophylls Nutrition 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
- 235000013618 yogurt Nutrition 0.000 description 1
- BLGXFZZNTVWLAY-SCYLSFHTSA-N yohimbine Chemical compound C1=CC=C2C(CCN3C[C@@H]4CC[C@H](O)[C@@H]([C@H]4C[C@H]33)C(=O)OC)=C3NC2=C1 BLGXFZZNTVWLAY-SCYLSFHTSA-N 0.000 description 1
- 235000010930 zeaxanthin Nutrition 0.000 description 1
- 239000001775 zeaxanthin Substances 0.000 description 1
- 229940043269 zeaxanthin Drugs 0.000 description 1
- 239000005019 zein Substances 0.000 description 1
- 229940093612 zein Drugs 0.000 description 1
- 239000004246 zinc acetate Substances 0.000 description 1
- 229940102001 zinc bromide Drugs 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- SRWMQSFFRFWREA-UHFFFAOYSA-M zinc formate Chemical compound [Zn+2].[O-]C=O SRWMQSFFRFWREA-UHFFFAOYSA-M 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 229940118827 zinc phenolsulfonate Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- BOVNWDGXGNVNQD-UHFFFAOYSA-L zinc;2-hydroxybenzenesulfonate Chemical compound [Zn+2].OC1=CC=CC=C1S([O-])(=O)=O.OC1=CC=CC=C1S([O-])(=O)=O BOVNWDGXGNVNQD-UHFFFAOYSA-L 0.000 description 1
- XLMCDAMBOROREP-UHFFFAOYSA-N zinc;3-phosphonooxypropane-1,2-diolate Chemical compound [Zn+2].OP(O)(=O)OCC([O-])C[O-] XLMCDAMBOROREP-UHFFFAOYSA-N 0.000 description 1
- AGFGXVAAIXIOFZ-UHFFFAOYSA-L zinc;butanedioate Chemical compound [Zn+2].[O-]C(=O)CCC([O-])=O AGFGXVAAIXIOFZ-UHFFFAOYSA-L 0.000 description 1
- NDKWCCLKSWNDBG-UHFFFAOYSA-N zinc;dioxido(dioxo)chromium Chemical compound [Zn+2].[O-][Cr]([O-])(=O)=O NDKWCCLKSWNDBG-UHFFFAOYSA-N 0.000 description 1
- 239000001432 zingiber officinale rosc. oleoresin Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23G—COCOA; COCOA PRODUCTS, e.g. CHOCOLATE; SUBSTITUTES FOR COCOA OR COCOA PRODUCTS; CONFECTIONERY; CHEWING GUM; ICE-CREAM; PREPARATION THEREOF
- A23G4/00—Chewing gum
- A23G4/02—Apparatus specially adapted for manufacture or treatment of chewing gum
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/375—Plasticisers, homogenisers or feeders comprising two or more stages
- B29C48/385—Plasticisers, homogenisers or feeders comprising two or more stages using two or more serially arranged screws in separate barrels
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/405—Intermeshing co-rotating screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/395—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders
- B29C48/40—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using screws surrounded by a cooperating barrel, e.g. single screw extruders using two or more parallel screws or at least two parallel non-intermeshing screws, e.g. twin screw extruders
- B29C48/41—Intermeshing counter-rotating screws
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/50—Details of extruders
- B29C48/505—Screws
- B29C48/57—Screws provided with kneading disc-like elements, e.g. with oval-shaped elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/50—Details of extruders
- B29C48/505—Screws
- B29C48/67—Screws having incorporated mixing devices not provided for in groups B29C48/52 - B29C48/66
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
- B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
- B29C48/00—Extrusion moulding, i.e. expressing the moulding material through a die or nozzle which imparts the desired form; Apparatus therefor
- B29C48/25—Component parts, details or accessories; Auxiliary operations
- B29C48/36—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die
- B29C48/362—Means for plasticising or homogenising the moulding material or forcing it through the nozzle or die using static mixing devices
Definitions
- This invention generally relates to methods and systems for mixing and forming gum structures, and more particularly methods and systems that use continuous mixing, batch mixing, or combinations thereof to add subsequent gum ingredients to gum base ingredients prior to forming a gum base.
- Traditional gum making has conventionally employed a two-step process including, a first step of mixing a gum base and then in a second subsequent step, mixing the gum base with subsequent gum ingredients.
- the gum base is made by mixing various gum base ingredients.
- the gum base is generally the water insoluble portion of the overall gum that is retained in the mouth throughout the chewing process.
- the insoluble gum base generally includes elastomers, elastomer plasticizers, resins, fats, oils, waxes, softeners, and filler components. Examples of several mixers arranged in a series for making gum bases are shown in U.S.
- Such mixers may be employed in the present invention.
- the Applicant hereby incorporates the teachings and disclosures of these patents by reference in their entireties to the extent not inconsistent with the present disclosure.
- the next traditional step in the gum making process is using the finished gum base as an ingredient in a separate downstream mixer.
- the finished gum base forms one ingredient, which is mixed with water soluble subsequent gum ingredients.
- water soluble subsequent gum ingredients generally include the water soluble bulk portion of the gum, which dissolves and dissipates in the mouth over a given time period during chewing.
- the gum base is differentiated from finished gum composition ingredients, usually, based upon being the water insoluble portion of the finished gum rather than the water soluble.
- subsequent gum ingredients which are added after the formation of a finished gum base, include for example, softeners, bulk sweeteners, high intensity sweeteners, flavoring agents, syrups, sensates, acids, potentiators, colorants and functional ingredients.
- multiple mixers are employed as opposed to a single mixer in order to produce a gum structure.
- the gum structure is a broad term that is meant to include at a minimum compounded elastomer material up to and including a finished chewing gum product.
- One aspect of the present invention is directed toward a nontraditional mixing system for making a gum structure, including a first mixer, a second mixer, and a third mixer wherein the second and the third mixers are arranged in parallel with each other and in series with the first mixer.
- Another aspect of the present invention is a mixing system for making a gum structure, including a first mixer, a second mixer, and a third mixer wherein the second and the third mixers are arranged in parallel with each other and in series with the first mixer.
- the mixing system also includes a plurality of ingredient feeders, wherein at least one of the ingredient feeders is arranged to input a subsequent gum ingredient to one of the mixers prior to generating a finished gum base.
- Yet another aspect of the present invention is a mixing system for making a gum structure, including a first mixer, a second mixer, and a third mixer wherein the second and the third mixers are arranged in parallel with each other and in series with the first mixer.
- One of the mixers is configured to form a finished gum base and to mix at least some subsequent gum ingredients to form a gum structure more than the finished gum base.
- One of the aspects of the present invention is a mixing system for making a gum structure, including a first mixer, a second mixer, and a third mixer wherein the second and the third mixers are arranged in parallel with each other and in series with the first mixer.
- the third mixer adapted to receive at least part of a first gum structure from the first mixer and at least part of a second gum structure from the second mixer, producing a third gum structure.
- Another aspect of the present invention is a mixing system for making a gum structure, including a first mixer arranged in series with a second mixer and a third mixer, wherein the second mixer and the third mixer are arranged in parallel with each other. Each of the second mixer and the third mixer outputs a different gum structure, wherein at least one of the second and third mixers outputs a gum structure less than a finished gum.
- One aspect of the present invention is directed toward a nontraditional method for making a chewing gum structure that comprises mixing a first set of ingredients in parallel with mixing a second set of ingredients, and mixing a third set of ingredients in series with mixing of the first and second sets of ingredients to form gum structures. At least one of the gum structures produced by the series mixing of the first and second sets of ingredients with the third set of ingredients is a gum structure less than a finished gum.
- Yet another aspect of the present invention is a method for making a gum structure that comprises mixing a first set of ingredients in parallel with mixing a second set of ingredients to form a first and second gum structure. And mixing a third set of ingredients in series with mixing of the first and second sets of ingredients to form a third gum structure, and mixing a fourth set of ingredients in series with mixing of the first and second sets of ingredients to form a fourth gum structure.
- FIG. 1 is a simplified schematic of a first embodiment of a gum structure mixing system including three continuous mixers in series;
- FIG. 2 is a simplified schematic of a second embodiment of a gum structure mixing system including a first continuous mixer, a second continuous mixer, and a batch mixer aligned generally in series;
- FIG. 3 is a simplified schematic of a third embodiment of a gum structure mixing system including a first continuous mixer, a batch mixer, and a second continuous mixer aligned generally in series;
- FIG. 4 is a simplified schematic of a fourth embodiment of a gum structure mixing system including a continuous mixer, a first batch mixer, and a second batch mixer aligned generally in series;
- FIG. 5 is a simplified schematic of a fifth embodiment of a gum structure mixing system including a first continuous mixer and a second continuous mixer aligned generally in series;
- FIG. 6 is a simplified schematic of a sixth embodiment of a gum structure mixing system including a continuous mixer and a batch mixer aligned generally in series;
- FIG. 7 is a simplified schematic of a seventh embodiment of a gum structure mixing system including a first batch mixer, a second batch mixer, and a third batch mixer aligned generally in series;
- FIG. 8 is a simplified schematic of an eight embodiment of a gum structure mixing system including a first batch mixer, a second batch mixer, and a continuous mixer aligned generally in series;
- FIG. 9 is a simplified schematic of a ninth embodiment of a gum structure mixing system including a first batch mixer, continuous mixer and a second batch mixer aligned generally in series;
- FIG. 10 is a simplified schematic of a tenth embodiment of a gum structure mixing system including a batch mixer, a first continuous mixer and a second continuous mixer aligned generally in series;
- FIG. 11 is a simplified schematic of a third embodiment of a gum structure mixing system including a batch mixer and a continuous mixer aligned generally in series;
- FIG. 12 is a simplified schematic of a third embodiment of a gum structure mixing system including a first batch mixer and a second batch mixer aligned generally in series;
- FIG. 13 is a simplified schematic illustration of a gum structure mixing system configured for kitting gum structures, where a portion of the system is located at a first location and a second portion of the system for finishing the gum structure is located at a second location, remote from the first;
- FIG. 14 is a simplified schematic of a first embodiment of a parallel gum structure mixing system including two mixers arranged in parallel with each other and in series with an upstream mixer;
- FIG. 15 is a simplified schematic of a second embodiment of a parallel gum structure mixing system including two mixers arranged in parallel with each other and in series with a downstream mixer;
- FIG. 16 is a simplified schematic of a third embodiment of a parallel gum structure mixing system including a first mixer and a second mixer arranged in parallel with each other and in series with a third mixer and a fourth mixer which are arranged in parallel with each other.
- FIG. 17 is a simplified schematic of a first variation of the first embodiment of FIG. 14 including recirculation of outputs;
- FIG. 18 is a simplified schematic of a second variation of the first embodiment of FIG. 14 wherein an output of a mixer is directed to another mixer arranged in parallel with the mixer;
- FIG. 19 is a simplified schematic of a third variation of the first embodiment of FIG. 14 further including two more mixers arranged in parallel with each other;
- FIG. 20 is a simplified schematic of a variation of the embodiment of FIG. 19 showing that ingredients may be added at different mixers using an ingredient feeder;
- FIG. 21 is a simplified schematic of another variation of the embodiment of FIG. 19 including recirculation of outputs within the mixing system;
- FIG. 22 is a simplified schematic of yet another variation of the embodiment of FIG. 19 including different recirculation of outputs within the mixing system;
- FIG. 23 is a simplified schematic of a first variation of the second embodiment of FIG. 15 including recirculation of outputs
- FIG. 24 is a simplified schematic of a second variation of the second embodiment of FIG. 15 wherein an output of a mixer is directed to another mixer arranged in parallel with the mixer;
- FIG. 25 is a simplified schematic of a third variation of the second embodiment of FIG. 15 including different recirculation of outputs;
- FIG. 26 is a simplified schematic of a fourth variation of the second embodiment of FIG. 15 including yet another recirculation of outputs;
- FIG. 27 is a simplified schematic of a first particular example of a parallel mixing system including three continuous mixers arranged in parallel with each other and in series with two other continuous mixers;
- FIG. 28 is a simplified schematic of a second particular example of a parallel mixing system including three batch mixers arranged in parallel with each other and in series with two continuous mixers;
- FIG. 29 is a simplified schematic of a third particular example of a parallel mixing system including two continuous mixers and a batch mixer arranged in parallel with each other and in series with another batch mixer;
- FIG. 30 is a simplified schematic of a fourth particular example of a parallel mixing system including three batch mixers arranged in parallel with each other and in series with a continuous mixer;
- FIG. 31 is a simplified schematic of a fifth particular example of a parallel mixing system including three continuous mixers arranged in parallel with each other and in series with a batch mixer which is arranged in series and upstream of another continuous mixer;
- FIG. 32 is a simplified schematic of a sixth particular example of a parallel mixing system including a batch mixer arranged in parallel with a continuous mixer, which are arranged in series and upstream of another batch mixer and a continuous mixer arranged in parallel with each other; and
- FIG. 33 is a simplified schematic of a seventh particular example of a parallel mixing system including a continuous mixer and a batch mixer arranged in parallel with each other and in series with another batch mixer which is arranged in series and upstream of another continuous mixer.
- “gum structure” includes, but is not limited to, compositions ranging from and inclusive of compounded elastomer to finished gum, which may include compounded elastomer in addition to some compounding aids, master batch gum base, compounded elastomer in addition to some subsequent gum ingredients, compounded elastomer in addition to some gum base ingredients and some subsequent gum ingredients, gum base, gum base in addition to some subsequent gum ingredients, master batch finished gum, and finished gum.
- a "finished gum”, as used herein, will refer to a gum structure that is generally ready for preparation to distribute the product to the consumer. As such, a finished gum may still require temperature conditioning, forming, shaping, packaging and coating. However, the gum composition itself is generally finished. Not all finished gums have the same ingredients or the same amounts of individual ingredients. By varying the ingredients and amounts of ingredients, textures, flavor and sensations, among other things, can be varied to provide differing characteristics to meet the needs of users.
- a finished gum generally includes a water soluble bulk portion, a water insoluble gum base portion, and one or more flavoring agents.
- the water soluble portion dissipates over a period of time during chewing.
- the gum base portion is retained in the mouth throughout the chewing process.
- a finished gum is typically ready for user consumption.
- a "finished gum base”, as used herein, will refer to a gum structure that includes a sufficient combination of gum base ingredients that need only be combined with subsequent gum ingredients to form a finished gum.
- a finished gum base is a chewable visco-elastic material that includes at least a viscous component, an elastic component, and a softener component.
- a typical gum base may include elastomer, at least some of the filler, resin and/or plasticizer, polyvinyl acetate, and a softener (such as an oil, fat or wax).
- a softener such as an oil, fat or wax
- Gum structures may include a vast number of ingredients in various categories.
- Systems and methods of the present invention may be used to mix any and all known ingredients including, but not limited to, ingredients in the following ingredient categories: elastomers, bulking agents, elastomer plasticizers (which includes resins), elastomer solvents, plasticizers, fats, waxes, fillers, antioxidants, sweeteners (e.g. bulk sweeteners and high intensity sweeteners), syrups/fluids, flavors, sensates, potentiators, acids, emulsif ⁇ ers, colors, and functional ingredients.
- elastomers elastomer plasticizers (which includes resins), elastomer solvents, plasticizers, fats, waxes, fillers, antioxidants, sweeteners (e.g. bulk sweeteners and high intensity sweeteners), syrups/fluids, flavors, sensates, potentiators, acids, emulsif ⁇ ers, colors, and functional ingredients.
- the insoluble gum base generally includes ingredients falling under the following categories: elastomers, elastomer plasticizers (resins or solevents), plasticizers, fats, oils, waxes, softeners and fillers. Further discussion of representative ingredients within each category will be provided later on.
- the gum base may constitute between 5- 95% by weight of a finished gum, more typically 10-50% by weight of the finished gum, and most commonly 20-30% by weight of the finished gum.
- the water soluble portion of finished gum may includes subsequent gum ingredients falling under the following categories: softeners, bulk sweeteners, high intensity sweeteners, flavoring agents, acids, additional fillers, functional ingredients and combinations thereof.
- Softeners are added to the gum in order to optimize the chewability and mouth feel of the gum.
- the softeners which are also known as plasticizers, plasticizing agents or emulsif ⁇ ers, generally constitute between about 0.5-15% by weight of the gum structure.
- Bulk sweeteners constitute between 5-95% by weight of the gum structure, more typically 20-80% by weight of the gum and most commonly 30-60% by weight of the gum.
- High intensity sweeteners may also be present and are commonly used with sugarless sweeteners. When used, high intensity sweeteners typically constitute between 0.001-5% by weight of the gum structure, preferably between 0.01-3% by weight of the chewing gum. Typically, high intensity sweeteners are at least 20 times sweeter than sucrose.
- Flavor should generally be present in the gum in an amount within the range of about 0.1-15% by weight of the chewing gum, preferably between about 0.2-5% by weight of the gum, most preferably between about 0.5-3% by weight of the gum. Natural and artificial flavoring agents may be used and combined in any sensorially acceptable fashion.
- acids typically constitute between about 0.001-5% by weight of the gum structure.
- Optional ingredients such as colors, functional ingredients and additional flavoring agents may also be included in gum structures.
- the elastomers (rubbers) employed in the gum structure will vary greatly depending upon various factors such as the type of gum structure desired, the consistency of gum structure desired and the other components used in the gum structure.
- the elastomer may be any water-insoluble polymer known in the art, and includes those polymers utilized for chewing gums and bubble gums.
- suitable polymers in gum structures, and particularly gum bases include both natural and synthetic elastomers.
- those polymers which are suitable in gum structures include, without limitation, natural substances (of vegetable origin) such as caspi, chicle, natural rubber, crown gum, nispero, rosidinha, jelutong, guayule, perillo, niger gutta, tunu, balata, guttapercha, lechi capsi, sorva, gutta kay, and the like, and combinations thereof.
- synthetic elastomers include, without limitation, styrene-butadiene copolymers (SBR), polyisobutylene, isobutylene-isoprene copolymers, polyethylene, polyvinyl acetate and the like, and combinations thereof. Elastomers constitute between about 10% to about 60% by weight and more commonly between about 35-40% by weight of the gum structure.
- Additional useful polymers include: crosslinked polyvinyl pyrrolidone, polymethylmethacrylate; copolymers of lactic acid, polyhydroxyalkanoates, plasticized ethylcellulose, polyvinyl acetatephthalate and combinations thereof.
- the gum structure may contain elastomer solvents, also referred to herein as elastomer plasticizers, to aid in softening the elastomeric materials.
- elastomer solvents may include those elastomer solvents known in the art, for example, terpinene resins such as polymers of alpha-pinene, beta-pinene or d-limonene, methyl, glycerol and pentaerythritol esters of rosins and modified rosins and gums such as hydrogenated, dimerized and polymerized rosins, and mixtures thereof.
- elastomer solvents suitable for use herein may include the pentaerythritol ester of partially hydrogenated wood and gum rosin, the pentaerythritol ester of wood and gum rosin, the glycerol ester of wood rosin, the glycerol ester of partially dimerized wood and gum rosin, the glycerol ester of polymerized wood and gum rosin, the glycerol ester of tall oil rosin, the glycerol ester of wood and gum rosin and the partially hydrogenated wood and gum rosin and the partially hydrogenated methyl ester of wood and rosin, and the like, and mixtures thereof.
- the elastomer solvent may be employed in the gum structure in amounts from about 2% to about 15%, and preferably from about 7% to about 11%, by weight of the gum structure.
- the gum structure may also include plasticizers or softeners, which also fall under the Wax category described below, to provide a variety of desirable textures and consistency properties. Because of the low molecular weight of these ingredients, the plasticizers and softeners are able to penetrate the fundamental structure of the gum structure making it plastic and less viscous.
- Useful plasticizers and softeners include triacetin, medium chain triglycerides of non-hydrogenated, partially hydrogenated cotton seed oil, soybean oil, palm oil, palm kernel oil, coconut oil, safflower oil, tallow oil, cocoa butter, terepene resins derived from alpha-pinene, lanolin, palmitic acid, oleic acid, stearic acid, sodium stearate, potassium stearate, glyceryl triacetate, glyceryl lecithin, glyceryl monostearate, propylene glycol monostearate, acetylated monoglyceride, glycerine, and the like, and mixtures thereof.
- Waxes for example, natural and synthetic waxes, hydrogenated vegetable oils, petroleum waxes such as polyurethane waxes, polyethylene waxes, paraffin waxes, sorbitan monostearate, tallow, propylene glycol, mixtures thereof, and the like, may also be incorporated into the gum structure.
- the plasticizers and softeners are generally employed in the gum structure in amounts up to about 20% by weight of the gum structure, and more specifically in amounts from about 9% to about 17%, by weight of the gum structure.
- Plasticizers may also include hydrogenated vegetable oils, soybean oil and cottonseed oil which may be employed alone or in combination. These plasticizers provide the gum structure with good texture and soft chew characteristics. These plasticizers and softeners are generally employed in amounts from about 5% to about 14%, and more specifically in amounts from about 5% to about 13.5%, by weight of the gum structure.
- Suitable oils and fats include partially hydrogenated vegetable or animal fats, such as coconut oil, palm kernel oil, beef tallow, and lard, among others. These ingredients when used are generally present in amounts up to about 7%, and preferably up to about 3.5%, by weight of the gum structure.
- the gum structure may include wax.
- Waxes that are used may include synthetic waxes such as waxes containing branched alkanes and copolymerized with monomers such as, but not limited to, polypropylene and polyethylene and Fischer- Tropsch type waxes, petroleum waxes such as paraffin, and microcrystalline wax, and natural waxes such as beeswax, candellia, carnauba, and polyethylene wax, rice bran and petroleum.
- the waxes employed will have a melting point below about 6O 0 C, and preferably between about 45 0 C and about 55 0 C.
- the low melting wax may be a paraffin wax.
- the wax may be present in the gum structure in an amount from about 6% to about 10%, and preferably from about 7% to about 9.5%, by weight of the gum structure.
- waxes having a higher melting point may be used in the gum structure in amounts up to about 5%, by weight of the gum structure.
- high melting waxes include beeswax, vegetable wax, candelilla wax, carnuba wax, most petroleum waxes, and the like, and mixtures thereof.
- gum structures formed using the systems and methods according to the teachings of the invention may also include effective amounts of bulking agents such as mineral adjuvants which may serve as fillers and textural agents.
- mineral adjuvants include calcium carbonate, magnesium carbonate, alumina, aluminum hydroxide, aluminum silicate, talc, clay, titanium oxide, ground limestone, monocalcium phosphate, tricalcium phosphate, dicalcium phosphate, calcium sulfate and the like, and mixtures thereof.
- These fillers or adjuvants may be used in the gum structure in various amounts.
- the amount of filler may be present in an amount from about zero to about 40%, and more specifically from about zero to about 30%, by weight of the gum structure. In some embodiments, the amount of filler will be from about zero to about 15%, more specifically from about 3% to about 11%.
- Antioxidants can include materials that scavenge free radicals.
- antioxidants can include but are not limited to ascorbic acid, citric acid (citric acid may be encapsulated), rosemary oil, vitamin A, vitamin E, vitamin E phosphate, butylated hydroxytoluene (BHT), butylated hydroxyanisole (BHA), propyl gallate, tocopherols, di-alpha-tocopheryl phosphate, tocotrienols, alpha lipoic acid, dihydrolipoic acid, xanthophylls, beta cryptoxanthin, lycopene, lutein, zeaxanthin, astaxanthin, beta- carotene, carotenes, mixed carotenoids, polyphenols, flavonoids, and combinations thereof.
- the gum structure may also include amounts of conventional additives selected from the group consisting of sweetening agents (bulk and high intensity sweeteners), softeners, emulsifiers, fillers, bulking agents (carriers, extenders, bulk sweeteners), flavoring agents (flavors, flavorings), coloring agents (colorants, colorings), functional ingredients, and the like, and mixtures thereof.
- sweetening agents bulk and high intensity sweeteners
- softeners emulsifiers
- fillers emulsifiers
- bulking agents carriers, extenders, bulk sweeteners
- flavoring agents flavors, flavorings
- coloring agents colorants, colorings
- functional ingredients and the like, and mixtures thereof.
- additives may serve more than one purpose.
- a sweetener such as maltitol or other sugar alcohol, may also function as a bulking agent and particularly a water soluble bulking agent.
- Suitable Bulk Sweeteners include monosaccharides, disaccharides and polysaccharides such as xylose, ribulose, glucose (dextrose), lactose, mannose, galactose, fructose (levulose), sucrose (sugar), maltose, invert sugar, partially hydrolyzed starch and corn syrup solids, sugar alcohols, randomly bonded glucose polymers such as those polymers distributed under the tradename LitesseTM which is the brand name for polydextrose and is manufactured by Danisco Sweeteners, Ltd.
- isomalt a racemic mixture of alpha-D- glucopyranosyl-l,6-mannitol and alpha-D-glucopyranosyl-l,6-sorbitol manufactured under the tradename PALATINITTM by Palatinit Sussungsstoff GmbH of Gotsch-Daimler- Strause 12 a, 68165 Mannheim, Germany
- maltodextrins hydrogenated starch hydrolysates; hydrogenated hexoses; hydrogenated disaccharides; minerals, such as calcium carbonate, talc, titanium dioxide, dicalcium phosphate; celluloses; and mixtures thereof.
- Suitable sugarless bulk sweeteners include sorbitol, xylitol, mannitol, galactitol, lactitol, maltitol, erythritol, isomalt and mixtures thereof.
- Suitable hydrogenated starch hydrolysates include those disclosed in U.S. Pat. No. 4,279,931 and various hydrogenated glucose syrups and/or powders which contain sorbitol, maltitol, hydrogenated disaccharides, hydrogenated higher polysaccharides, or mixtures thereof. Hydrogenated starch hydrolysates are primarily prepared by the controlled catalytic hydrogenation of corn syrups.
- the resulting hydrogenated starch hydrolysates are mixtures of monomeric, dimeric, and polymeric saccharides.
- the ratios of these different saccharides give different hydrogenated starch hydro lysates different properties.
- Mixtures of hydrogenated starch hydrolysates, such as LYCASIN®, a commercially available product manufactured by Roquette Freres of France, and HYSTAR®, a commercially available product manufactured by SPI Polyols, Inc. of New Castle, Delaware, are also useful.
- the gum structure may include a specific polyol composition including at least one polyol which is from about 30% to about 80% by weight of said gum structure, and specifically from 50% to about 60%. In some embodiments, such gum structures may have low hygroscopicity.
- the polyol composition may include any polyol known in the art including, but not limited to maltitol, sorbitol, erythritol, xylitol, mannitol, isomalt, lactitol and combinations thereof. LycasinTM which is a hydrogenated starch hydrolysate including sorbitol and maltitol, may also be used.
- the amount of the polyol composition or combination of polyols used in the gum structure will depend on many factors including the type of elastomers used in the gum structure and the particular polyols used. For example, wherein the total amount of the polyol composition is in the range of about 40% to about 65% based on the weight of the gum structure, the amount of isomalt may be from about 40% to about 60% in addition to an amount of sorbitol from about 0 up to about 10%, more specifically, an amount of isomalt may be from about 45% to about 55% in combination with sorbitol from about 5% to about 10% based on the weight of the gum structure.
- the polyol composition which may include one or more different polyols which may be derived from a genetically modified organism ("GMO") or GMO free source.
- GMO genetically modified organism
- the maltitol may be GMO free maltitol or provided by a hydrogenated starch hydrolysate.
- GMO-free refers to a composition that has been derived from process in which genetically modified organisms are not utilized.
- the sweetening agents which may be included in some gum structures formed using systems and methods according to the teachings of the present invention may be any of a variety of sweeteners known in the art and may be used in many distinct physical forms well-known in the art to provide an initial burst of sweetness and/or a prolonged sensation of sweetness. Without being limited thereto, such physical forms include free forms, such as spray dried, powdered, beaded forms, encapsulated forms, and mixtures thereof.
- the sweetener is a high intensity sweetener such as aspartame, neotame, sucralose, monatin, and acesulfame potassium (Ace-K).
- the high intensity sweetener can be in an encapsulated form, a free form, or both.
- an effective amount of sweetener may be utilized to provide the level of sweetness desired, and this amount may vary with the sweetener selected.
- the amount of sweetener may be present in amounts from about 0.001% to about 3%, by weight of the gum, depending upon the sweetener or combination of sweeteners used. The exact range of amounts for each type of sweetener may be selected by those skilled in the art.
- the sweeteners involved may be selected from a wide range of materials including water-soluble sweeteners, water-soluble artificial sweeteners, water-soluble sweeteners derived from naturally occurring water-soluble sweeteners, dipeptide based sweeteners, and protein based sweeteners, including mixtures thereof. Without being limited to particular sweeteners, representative categories and examples include:
- water-soluble sweetening agents such as dihydrochalcones, monellin, steviosides, Io han quo, Io han quo derivatives, glycyrrhizin, dihydroflavenol, and sugar alcohols such as sorbitol, mannitol, maltitol, xylitol, erythritol, and L-aminodicarboxylic acid aminoalkenoic acid ester amides, such as those disclosed in U.S. Pat. No. 4,619,834, which disclosure is incorporated herein by reference, and mixtures thereof;
- water-soluble sweetening agents such as dihydrochalcones, monellin, steviosides, Io han quo, Io han quo derivatives, glycyrrhizin, dihydroflavenol, and sugar alcohols such as sorbitol, mannitol, maltitol, xylito
- water-soluble artificial sweeteners such as soluble saccharin salts, i.e., sodium or calcium saccharin salts, cyclamate salts, the sodium, ammonium or calcium salt of 3,4-dihydro-6-methyl-l,2,3-oxathiazine-4-one-2,2-dioxide, the potassium salt of 3,4- dihydro-6-methyl-l,2,3-oxathiazine-4-one-2,2-dioxide (Acesulfame-K), the free acid form of saccharin, and mixtures thereof;
- soluble saccharin salts i.e., sodium or calcium saccharin salts, cyclamate salts
- the sodium, ammonium or calcium salt of 3,4-dihydro-6-methyl-l,2,3-oxathiazine-4-one-2,2-dioxide the potassium salt of 3,4- dihydro-6-methyl-l,2,3-oxathiazine-4-one-2,2-dioxide
- dipeptide based sweeteners such as L-aspartic acid derived sweeteners, such as L-aspartyl-L-phenylalanine methyl ester (Aspartame), N-[N-(3,3-dimethylbutyl)-L- ⁇ - aspartyl]-L-phenylalanine 1 -methyl ester (Neotame), and materials described in U.S. Pat. No.
- the intense sweetening agents may be used in many distinct physical forms well-known in the art to provide an initial burst of sweetness and/or a prolonged sensation of sweetness. Without being limited thereto, such physical forms include free forms, spray dried forms, powdered forms, beaded forms, encapsulated forms, and mixtures thereof.
- the sweetener is a high intensity sweetener such as aspartame, sucralose, and acesulfame potassium (e.g., Ace-K or acesulfame-K).
- acesulfame potassium e.g., Ace-K or acesulfame-K
- the active component e.g., sweetener
- the active component which is part of the delivery system, may be used in amounts necessary to impart the desired effect associated with use of the active component (e.g., sweetness).
- an effective amount of intense sweetener may be utilized to provide the level of sweetness desired, and this amount may vary with the sweetener selected.
- the intense sweetener may be present in amounts from about 0.001% to about 3%, by weight of the composition, depending upon the sweetener or combination of sweeteners used. The exact range of amounts for each type of sweetener may be selected by those skilled in the art.
- Anhydrous glycerin may also be employed as a softening agent, such as the commercially available United States Pharmacopeia (USP) grade.
- Glycerin is a syrupy liquid with a sweet warm taste and has a sweetness of about 60% of that of cane sugar. Because glycerin is hygroscopic, the anhydrous glycerin may be maintained under anhydrous conditions throughout the preparation of the gum structure.
- Other syrups may include corn syrup and maltitol syrup.
- flavorants may include those flavors known to the skilled artisan, such as natural and artificial flavors. These flavorings may be chosen from synthetic flavor oils and flavoring aromatics and/or oils, oleoresins and extracts derived from plants, leaves, flowers, fruits, and so forth, and combinations thereof.
- Nonlimiting representative flavor oils include spearmint oil, cinnamon oil, oil of wintergreen (methyl salicylate), peppermint oil, Japanese mint oil, clove oil, bay oil, anise oil, eucalyptus oil, thyme oil, cedar leaf oil, oil of nutmeg, allspice, oil of sage, mace, oil of bitter almonds, and cassia oil.
- sweetenings are artificial, natural and synthetic fruit flavors such as vanilla, and citrus oils including lemon, orange, lime, grapefruit, yazu, sudachi, and fruit essences including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, apricot, banana, melon, apricot, ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya and so forth.
- fruit flavors such as vanilla, and citrus oils including lemon, orange, lime, grapefruit, yazu, sudachi, and fruit essences including apple, pear, peach, grape, blueberry, strawberry, raspberry, cherry, plum, pineapple, apricot, banana, melon, apricot, ume, cherry, raspberry, blackberry, tropical fruit, mango, mangosteen, pomegranate, papaya and so forth.
- Other potential flavors whose release profiles can be managed include a milk flavor, a butter flavor, a cheese flavor, a cream flavor, and a yogurt flavor; a vanilla flavor; tea or coffee flavors, such as a green tea flavor, a oolong tea flavor, a tea flavor, a cocoa flavor, a chocolate flavor, and a coffee flavor; mint flavors, such as a peppermint flavor, a spearmint flavor, and a Japanese mint flavor; spicy flavors, such as an asafetida flavor, an ajowan flavor, an anise flavor, an angelica flavor, a fennel flavor, an allspice flavor, a cinnamon flavor, a camomile flavor, a mustard flavor, a cardamom flavor, a caraway flavor, a cumin flavor, a clove flavor, a pepper flavor, a coriander flavor, a sassafras flavor, a savory flavor, a Zanthoxyli Fructus flavor, a perilla flavor, a
- flavoring agents may be used in liquid or solid form and may be used individually or in admixture.
- Commonly used flavors include mints such as peppermint, menthol, spearmint, artificial vanilla, cinnamon derivatives, and various fruit flavors, whether employed individually or in admixture. Flavors may also provide breath freshening properties, particularly the mint flavors when used in combination with the cooling agents, described herein below.
- flavorants may chose from geraniol, linalool, nerol, nerolidal, citronellol, heliotropine, methyl cyclopentelone, ethyl vanillin, maltol, ethyl maltol, furaneol, alliaceous compounds, rose type compounds such as phenethanol, phenylacetic acid, nerol, linalyl esters, jasmine, sandlewood, patchouli, and/or cedarwood.
- other flavorings include aldehydes and esters such as cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihydrocarvyl acetate, eugenyl formate, p-methylamisol, and so forth may be used.
- aldehydes and esters such as cinnamyl acetate, cinnamaldehyde, citral diethylacetal, dihydrocarvyl acetate, eugenyl formate, p-methylamisol, and so forth may be used.
- any flavoring or food additive such as those described in Chemicals Used in Food Processing, publication 1274, pages 63-258, by the National Academy of Sciences, may be used. This publication is incorporated herein by reference. These may include natural as well as synthetic flavors.
- aldehyde flavorings include but are not limited to acetaldehyde (apple), benzaldehyde (cherry, almond), anisic aldehyde (licorice, anise), cinnamic aldehyde (cinnamon), citral, i.e., alpha-citral (lemon, lime), neral, i.e., beta-citral (lemon, lime), decanal (orange, lemon), ethyl vanillin (vanilla, cream), heliotrope, i.e., piperonal (vanilla, cream), vanillin (vanilla, cream), alpha-amyl cinnamaldehyde (spicy fruity flavors), butyraldehyde (butter, cheese), valeraldehyde (butter, cheese), citronellal (modifies, many types), decanal (citrus fruits), aldehyde C-8 (c
- flavoring agents are used at levels that provide a perceptible sensory experience i.e. at or above their threshold levels. In other embodiments, flavoring agents are used at levels below their threshold levels such that they do not provide an independent perceptible sensory experience. At subthreshold levels, the flavoring agents may provide an ancillary benefit such as flavor enhancement or potentiation.
- a flavoring agent may be employed in either liquid form and/or dried form. When employed in the latter form, suitable drying means such as spray drying the liquid may be used. Alternatively, the flavoring agent may be absorbed onto water soluble materials, such as cellulose, starch, sugar, maltodextrin, gum arabic and so forth or may be encapsulated. In still other embodiments, the flavoring agent may be adsorbed onto silicas, zeolites, and the like.
- the flavoring agents may be used in many distinct physical forms.
- such physical forms include free forms, such as spray dried, powdered, beaded forms, encapsulated forms, and mixtures thereof.
- encapsulation of flavors as well as other additional components can be found in the examples provided herein.
- encapsulation of a component will result in a delay in the release of the predominant amount of the component during consumption of a gum structure that includes the encapsulated component (e.g., as part of a delivery system added as an ingredient to the gum structure).
- the release profile of the ingredient e.g., the flavor, sweetener, etc.
- the ingredient can be managed by managing various characteristics of the ingredient, delivery system containing the ingredient, and/or the gum structure containing the delivery system and/or how the delivery system is made.
- characteristics might include one or more of the following: tensile strength of the delivery system, water solubility of the ingredient, water solubility of the encapsulating material, water solubility of the delivery system, ratio of ingredient to encapsulating material in the delivery system, average or maximum particle size of ingredient, average or maximum particle size of ground delivery system, the amount of the ingredient or the delivery system in the gum structure, ratio of different polymers used to encapsulate one or more ingredients, hydrophobicity of one or more polymers used to encapsulate one or more ingredients, hydrophobicity of the delivery system, the type or amount of coating on the delivery system, the type or amount of coating on an ingredient prior to the ingredient being encapsulated, etc.
- Sensate compounds can include cooling agents, warming agents, tingling agents, effervescent agents, and combinations thereof.
- cooling agents include xylitol, erythritol, dextrose, sorbitol, menthane, menthone, ketals, menthone ketals, menthone glycerol ketals, substituted p-menthanes, acyclic carboxamides, mono menthyl glutarate, substituted cyclohexanamides, substituted cyclohexane carboxamides, substituted ureas and sulfonamides, substituted menthanols, hydroxymethyl and hydroxymethyl derivatives of p-menthane, 2-mercapto-cyclo-decanone, hydroxycarboxylic acids with 2-6 carbon atoms, cyclohexanamides, menthyl
- warming components may be selected from a wide variety of compounds known to provide the sensory signal of warming to the user. These compounds offer the perceived sensation of warmth, particularly in the oral cavity, and often enhance the perception of flavors, sweeteners and other organoleptic components.
- useful warming compounds can include vanillyl alcohol n-butylether (TK-1000) supplied by Takasago Perfumary Company Limited, Tokyo, Japan, vanillyl alcohol n-propylether, vanillyl alcohol isopropylether, vanillyl alcohol isobutylether, vanillyl alcohol n-aminoether, vanillyl alcohol isoamyleather, vanillyl alcohol n-hexyleather, vanillyl alcohol methylether, vanillyl alcohol ethylether, gingerol, shogaol, paradol, zingerone, capsaicin, dihydrocapsaicin, nordihydrocapsaicin, homocapsaicin, homodihydrocapsaicin, ethanol, isopropyl alcohol, iso-amylalcohol, benzyl alcohol, glycerine, and combinations thereof.
- TK-1000 vanillyl alcohol n-buty
- a tingling sensation can be provided.
- One such tingling sensation is provided by adding jambu, oleoresin, or spilanthol to some examples.
- alkylamides extracted from materials such as jambu or sanshool can be included.
- a sensation is created due to effervescence. Such effervescence is created by combining an alkaline material with an acidic material.
- an alkaline material can include alkali metal carbonates, alkali metal bicarbonates, alkaline earth metal carbonates, alkaline earth metal bicarbonates and mixtures thereof.
- an acidic material can include acetic acid, adipic acid, ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid, glyconic acid, lactic acid, phosphoric acid, malic acid, oxalic acid, succinic acid, tartaric acid and combinations thereof.
- Examples of "tingling" type sensates can be found in U.S. Patent No. 6,780,443, the entire contents of which are incorporated herein by reference for all purposes.
- Sensate components may also be referred to as "trigeminal stimulants" such as those disclosed in U.S. Patent Application No. 205/0202118, which is incorporated herein by reference.
- Trigeminal stimulants are defined as an orally consumed product or agent that stimulates the trigeminal nerve.
- cooling agents which are trigeminal stimulants include menthol, WS-3, N-substituted p-menthane carboxamide, acyclic carboxamides including WS-23, methyl succinate, menthone glycerol ketals, bulk sweeteners such as xylitol, erythritol, dextrose, and sorbitol, and combinations thereof.
- Trigeminal stimulants can also include flavors, tingling agents, Jambu extract, vanillyl alkyl ethers, such as vanillyl n-butyl ether, spilanthol, Echinacea extract, Northern Prickly Ash extract, capsaicin, capsicum oleoresin, red pepper oleoresin, black pepper oleoresin, piperine, ginger oleoresin, gingerol, shoagol, cinnamon oleoresin, cassia oleoresin, cinnamic aldehyde, eugenol, cyclic acetal of vanillin and menthol glycerin ether, unsaturated amides, and combinations thereof.
- flavors, tingling agents such as vanillyl n-butyl ether, spilanthol, Echinacea extract, Northern Prickly Ash extract, capsaicin, capsicum oleoresin, red pepper oleoresin, black pepper oleoresin, pipe
- sensate components are used at levels that provide a perceptible sensory experience i.e. at or above their threshold levels. In other embodiments, sensate components are used at levels below their threshold levels such that they do not provide an independent perceptible sensory experience. At subthreshold levels, the sensates may provide an ancillary benefit such as flavor or sweetness enhancement or potentiation.
- Potentiators can include of materials that may intensify, supplement, modify or enhance the taste and/or aroma perception of an original material without introducing a characteristic taste and/or aroma perception of their own.
- potentiators designed to intensify, supplement, modify, or enhance the perception of flavor, sweetness, tartness, umami, kokumi, saltiness and combinations thereof can be included.
- potentiators also known as taste potentiators include, but are not limited to, neohesperidin dihydrochalcone, chlorogenic acid, alapyridaine, cynarin, miraculin, glupyridaine, pyridinium-betain compounds, glutamates, such as monosodium glutamate and monopotassium glutamate, neotame, thaumatin, tagatose, trehalose, salts, such as sodium chloride, monoammonium glycyrrhizinate, vanilla extract (in ethyl alcohol), sugar acids, potassium chloride, sodium acid sulfate, hydrolyzed vegetable proteins, hydrolyzed animal proteins, yeast extracts, adenosine monophosphate (AMP), glutathione, nucleotides, such as inosine monophosphate, disodium inosinate, xanthosine monophosphate,
- Sweetener potentiators which are a type of taste potentiator, enhance the taste of sweetness.
- exemplary sweetener potentiators include, but are not limited to, monoammonium glycyrrhizinate, licorice glycyrrhizinates, citrus aurantium, alapyridaine, alapyridaine (N-(I -carboxyethyl)-6-(hydroxymethyl)pyridinium-3-ol) inner salt, miraculin, curculin, strogin, mabinlin, gymnemic acid, cynarin, glupyridaine, pyridinium-betain compounds, sugar beet extract, neotame, thaumatin, neohesperidin dihydrochalcone, hydroxybenzoic acids, tagatose, trehalose, maltol, ethyl maltol, vanilla extract, vanilla
- Acidic peptides include peptides having a larger number of acidic amino acids, such as aspartic acid and glutamic acid, than basic amino acids, such as lysine, arginine and histidine.
- the acidic peptides are obtained by peptide synthesis or by subjecting proteins to hydrolysis using endopeptidase, and if necessary, to deamidation.
- Suitable proteins for use in the production of the acidic peptides or the peptides obtained by subjecting a protein to hydrolysis and deamidation include plant proteins, (e.g.
- wheat gluten e.g., corn protein (e.g., zein and gluten meal), soybean protein isolate), animal proteins (e.g., milk proteins such as milk casein and milk whey protein, muscle proteins such as meat protein and fish meat protein, egg white protein and collagen), and microbial proteins (e.g., microbial cell protein and polypeptides produced by microorganisms).
- animal proteins e.g., milk proteins such as milk casein and milk whey protein, muscle proteins such as meat protein and fish meat protein, egg white protein and collagen
- microbial proteins e.g., microbial cell protein and polypeptides produced by microorganisms.
- Acids can include, but are not limited to acetic acid, adipic acid, ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid, glyconic acid, lactic acid, phosphoric acid, malic acid, oxalic acid, succinic acid, tartaric acid, aspartic acid, benzoic acid, caffeotannic acid, iso-citric acid, citramalic acid, galacturonic acid, glucuronic acid, glyceric acid, glycolic acid, ketoglutaric acid, a-ketoglutaric acid, lactoisocitric acid, oxalacetic acid, pyruvic acid, quinic acid, shikimic acid, succinic acid, tannic acid, hydroxyacetic acid, suberic acid, sebacic acid, azelaic acid, pimelic acid, capric acid and combinations thereof.
- the gum structure may also include emulsifiers which aid in dispersing the immiscible components into a single stable system.
- the emulsifiers useful in this invention include glyceryl monostearate, lecithin, fatty acid monoglycerides, diglycerides, propylene glycol monostearate, methyl cellulose, alginates, carrageenan, xanthan gum, gelatin, carob, tragacanth, locust bean gum, pectin, alginates, galactomannans such as guar gum, carob bean gum, glucomannan, gelatin, starch, starch derivatives, dextrins and cellulose derivatives such as carboxy methyl cellulose, acidulants such as malic acid, adipic acid, citric acid, tartaric acid, fumaric acid, and the like, used alone and mixtures thereof.
- the emulsifier may be employed in amounts from about 2% to about 15%, and more specifically, from about 7%
- Coloring agents may be used in amounts effective to produce the desired color.
- the coloring agents may include pigments which may be incorporated in amounts up to about 6%, by weight of the gum.
- titanium dioxide may be incorporated in amounts up to about 2%, and preferably less than about 1%, by weight of the gum structure.
- the colorants may also include natural food colors and dyes suitable for food, drug and cosmetic applications. These colorants are known as F.D.& C. dyes and lakes.
- the materials acceptable for the foregoing uses are preferably water-soluble.
- Illustrative nonlimiting examples include the indigoid dye known as F.D.& C. Blue No.2, which is the disodium salt of 5,5-indigotindisulfonic acid.
- the dye known as F.D.& C. Green No.l comprises a triphenylmethane dye and is the monosodium salt of 4-[4-(N-ethyl-p- sulfoniumbenzylamino) diphenylmethylene]-[ 1 -(N-ethyl -N-p-sulfoniumbenzyl)-delta-2,5- cyclohexadieneimine].
- a full recitation of all F.D.& C. colorants and their corresponding chemical structures may be found in the Kirk-Othmer Encyclopedia of Chemical Technology, 3rd Edition, in volume 5 at pages 857-884, which text is incorporated herein by reference.
- colors can include exempt from certification colors (sometimes referred to as natural even though they can be synthetically manufactured) and certified colors (sometimes referred to as artificial), or combinations thereof.
- exempt from certification or natural colors can include, but are not limited to annatto extract, (E 160b), bixin, norbixin, astaxanthin, dehydrated beets (beet powder), beetroot red/betanin (E 162), ultramarine blue, canthaxanthin (El 6 Ig), cryptoxanthin (El 6 Ic), rubixanthin (El 6 Id), violanxanthin (E161e), rhodoxanthin (E161f), caramel (E150(a-d)), ⁇ -apo-8'-carotenal (E 16Oe), ⁇ -carotene (E 160a), alpha carotene, gamma carotene, ethyl ester of beta-apo-8 carotenal (E 16Of), flavoxanthin (E161a), lutein (E161b), cochineal extract (E120); carmine (E132), carmoisine/azorubine (
- certified colors can include, but are not limited to, FD&C blue #1, FD&C blue #2, FD&C green #3, FD&C red #3, FD&C red #40, FD&C yellow #5 and FD&C yellow #6, tartrazine (E 102), quinoline yellow (E 104), sunset yellow (El 10), ponceau (E 124), erythrosine (E 127), patent blue V (El 31), titanium dioxide (E 171), aluminium (E 173), silver (E 174), gold (E 175), pigment rubine/lithol rubine BK (E 180), calcium carbonate (E170), carbon black (E153), black PN/brilliant black BN (E151), green S/acid brilliant green BS (E 142), and combinations thereof.
- certified colors can include FD&C aluminum lakes. These include of the aluminum salts of FD&C dyes extended on an insoluble substrate of alumina hydrate. Additionally, in some embodiments,
- Additional additives including functional ingredients include physiological cooling agents, throat-soothing agents, spices, warming agents, tooth-whitening agents or other dental care ingredients, breath-freshening agents, vitamins, nutraceuticals, phytochemicals, polyphenols, antioxidants, active ingredients, minerals, caffeine, drugs and other actives may also be included in the gum composition. Such components may be used in amounts sufficient to achieve their intended effects and will be more fully discussed below.
- Breath fresheners can include essential oils as well as various aldehydes, alcohols, and similar materials.
- essential oils can include oils of spearmint, peppermint, wintergreen, sassafras, chlorophyll, citral, geraniol, cardamom, clove, sage, carvacrol, eucalyptus, cardamom, magnolia bark extract, marjoram, cinnamon, lemon, lime, grapefruit, and orange.
- aldehydes such as cinnamic aldehyde and salicylaldehyde can be used.
- chemicals such as menthol, carvone, iso-garrigol, and anethole can function as breath fresheners. Of these, the most commonly employed are oils of peppermint, spearmint and chlorophyll.
- breath fresheners can include but are not limited to zinc citrate, zinc acetate, zinc fluoride, zinc ammonium sulfate, zinc bromide, zinc iodide, zinc chloride, zinc nitrate, zinc flurosilicate, zinc gluconate, zinc tartarate, zinc succinate, zinc formate, zinc chromate, zinc phenol sulfonate, zinc dithionate, zinc sulfate, silver nitrate, zinc salicylate, zinc glycerophosphate, copper nitrate, chlorophyll, copper chlorophyll, chlorophyllin, hydrogenated cottonseed oil, chlorine dioxide, beta cyclodextrin, zeolite, silica-based materials, carbon-based materials, enzymes such as laccase, and combinations thereof.
- the release profiles of probiotics can be managed for a gum structure including, but not limited to lactic acid producing microorganisms such as Bacillus coagulans, Bacillus subtilis, Bacillus laterosporus, Bacillus laevolacticus, Sporolactobacillus inulinus, Lactobacillus acidophilus, Lactobacillus curvatus, Lactobacillus plantarum, Lactobacillus jenseni, Lactobacillus casei, Lactobacillus fermentum, Lactococcus lactis, Pedioccocus acidilacti, Pedioccocus pentosaceus, Pedioccocus urinae, Leuconostoc mesenteroides, Bacillus coagulans, Bacillus subtilis, Bacillus laterosporus, Bacillus laevolacticus, Sporolactobacillus inulinus and mixtures thereof.
- lactic acid producing microorganisms such as Bacillus coagulans
- Breath fresheners are also known by the following trade names: Retsyn,TM Actizol,TM and Nutrazin.TM Examples of malodor-controlling compositions are also included in U.S. Patent No. 5,300,305 to Stapler et al. and in U.S. Patent Application Publication Nos. 2003/0215417 and 2004/0081713 which are incorporated in their entirety herein by reference for all purposes.
- Dental care ingredients may include but are not limited to tooth whiteners, stain removers, oral cleaning, bleaching agents, desensitizing agents, dental remineralization agents, antibacterial agents, anticaries agents, plaque acid buffering agents, surfactants and anticalculus agents.
- Non-limiting examples of such ingredients can include, hydrolytic agents including proteolytic enzymes, abrasives such as hydrated silica, calcium carbonate, sodium bicarbonate and alumina, other active stain- removing components such as surface-active agents, including, but not limited to anionic surfactants such as sodium stearate, sodium palminate, sulfated butyl oleate, sodium oleate, salts of fumaric acid, glycerol, hydroxylated lecithin, sodium lauryl sulfate and chelators such as polyphosphates, which are typically employed as tartar control ingredients.
- hydrolytic agents including proteolytic enzymes, abrasives such as hydrated silica, calcium carbonate, sodium bicarbonate and alumina, other active stain- removing components such as surface-active agents, including, but not limited to anionic surfactants such as sodium stearate, sodium palminate, sulfated butyl oleate, sodium oleate, salts of
- dental care ingredients can also include tetrasodium pyrophosphate and sodium tri-polyphosphate, sodium bicarbonate, sodium acid pyrophosphate, sodium tripolyphosphate, xylitol, sodium hexametaphosphate.
- peroxides such as carbamide peroxide, calcium peroxide, magnesium peroxide, sodium peroxide, hydrogen peroxide, and peroxydiphospate are included.
- potassium nitrate and potassium citrate are included.
- Other examples can include casein glycomacropeptide, calcium casein peptone-calcium phosphate, casein phosphopeptides, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and amorphous calcium phosphate.
- Still other examples can include papaine, krillase, pepsin, trypsin, lysozyme, dextranase, mutanase, glycoamylase, amylase, glucose oxidase, and combinations thereof.
- Further examples can include surfactants such as sodium stearate, sodium ricinoleate, and sodium lauryl sulfate surfactants for use in some embodiments to achieve increased prophylactic action and to render the dental care ingredients more cosmetically acceptable.
- surfactants can preferably be detersive materials which impart to the composition detersive and foaming properties.
- Suitable examples of surfactants are water- soluble salts of higher fatty acid monoglyceride monosulfates, such as the sodium salt of the monosulfated monoglyceride of hydgrogenated coconut oil fatty acids, higher alkyl sulfates such as sodium lauryl sulfate, alkyl aryl sulfonates such as sodium dodecyl benzene sulfonate, higher alkyl sulfoacetates, sodium lauryl sulfoacetate, higher fatty acid esters of 1 ,2-dihydroxy propane sulfonate, and the substantially saturated higher aliphatic acyl amides of lower aliphatic amino carboxylic acid compounds, such as those having 12 to 16 carbons in the fatty acid, alkyl or acyl radicals, and the like.
- higher alkyl sulfates such as sodium lauryl sulfate, alkyl aryl sulfonates such as
- amides are N-lauroyl sarcosine, and the sodium, potassium, and ethanolamine salts of N- lauroyl, N-myristoyl, or N-palmitoyl sarcosine.
- dental care ingredients can include antibacterial agents such as, but not limited to, triclosan, chlorhexidine, zinc citrate, silver nitrate, copper, limonene, and cetyl pyridinium chloride.
- additional anticaries agents can include fluoride ions or fluorine-providing components such as inorganic fluoride salts.
- soluble alkali metal salts for example, sodium fluoride, potassium fluoride, sodium fluorosilicate, ammonium fluorosilicate, sodium monofluorophosphate, as well as tin fluorides, such as stannous fluoride and stannous chloride can be included.
- a fluorine-containing compound having a beneficial effect on the care and hygiene of the oral cavity may also be included as an ingredient.
- a fluorine-containing compound having a beneficial effect on the care and hygiene of the oral cavity e.g., diminution of enamel solubility in acid and protection of the teeth against decay
- examples thereof include sodium fluoride, stannous fluoride, potassium fluoride, potassium stannous fluoride (SnF. sub.2 -KF), sodium hexafluorostannate, stannous chlorofluoride, sodium fluorozirconate, and sodium monofluorophosphate.
- urea is included.
- Actives generally refer to those ingredients that are included in a delivery system and/or gum structure for the desired end benefit they provide to the user.
- actives can include medicaments, nutrients, nutraceuticals, herbals, nutritional supplements, pharmaceuticals, drugs, and the like and combinations thereof.
- Examples of useful drugs include ace-inhibitors, antianginal drugs, anti- arrhythmias, anti-asthmatics, anti-cholesterolemics, analgesics, anesthetics, anticonvulsants, anti-depressants, anti-diabetic agents, anti-diarrhea preparations, antidotes, anti-histamines, anti-hypertensive drugs, anti-inflammatory agents, anti-lipid agents, anti- manics, anti-nauseants, anti-stroke agents, anti-thyroid preparations, anti-tumor drugs, antiviral agents, acne drugs, alkaloids, amino acid preparations, anti-tussives, anti-uricemic drugs, anti-viral drugs, anabolic preparations, systemic and non-systemic anti-infective agents, anti-neoplasties, anti-parkinsonian agents, anti-rheumatic agents, appetite stimulants, biological response modifiers, blood modifiers, bone metabolism regulators, cardiovascular agents,
- Examples of active ingredients contemplated for use in some embodiments can include antacids, H2-antagonists, and analgesics.
- antacid dosages can be prepared using the ingredients calcium carbonate alone or in combination with magnesium hydroxide, and/or aluminum hydroxide.
- antacids can be used in combination with H2-antagonists.
- Analgesics include opiates and opiate derivatives, such as OxycontinTM, ibuprofen, aspirin, acetaminophen, and combinations thereof that may optionally include caffeine.
- Other drug active ingredients for use in embodiments can include anti-diarrheals such as ImmodiumTM AD, anti-histamines, anti-tussives, decongestants, vitamins, and breath fresheners.
- anti-diarrheals such as ImmodiumTM AD, anti-histamines, anti-tussives, decongestants, vitamins, and breath fresheners.
- anxiolytics such as XanaxTM
- antipsychotics such as ClozarilTM and HaldolTM
- non-steroidal anti-inflammatories (NSAID 's) such as ibuprofen, naproxen sodium, VoltarenTM and LodineTM, anti-histamines such as ClaritinTM, HismanalTM, RelafenTM, and TavistTM
- anti-emetics such as KytrilTM and CesametTM
- bronchodilators such as BentolinTM, ProventilTM
- anti-depressants such as Pro
- H2-antagonists which are contemplated for use in the present invention include cimetidine, ranitidine hydrochloride, famotidine, nizatidien, ebrotidine, mifentidine, roxatidine, pisatidine and aceroxatidine.
- Active antacid ingredients can include, but are not limited to, the following: aluminum hydroxide, dihydroxyaluminum aminoacetate, aminoacetic acid, aluminum phosphate, dihydroxyaluminum sodium carbonate, bicarbonate, bismuth aluminate, bismuth carbonate, bismuth subcarbonate, bismuth subgallate, bismuth subnitrate, bismuth subsilysilate, calcium carbonate, calcium phosphate, citrate ion (acid or salt), amino acetic acid, hydrate magnesium aluminate sulfate, magaldrate, magnesium aluminosilicate, magnesium carbonate, magnesium glycinate, magnesium hydroxide, magnesium oxide, magnesium trisilicate, milk solids, aluminum mono-ordibasic calcium phosphate, tricalcium phosphate, potassium bicarbonate, sodium tartrate, sodium bicarbonate, magnesium aluminosilicates, tartaric acids and salts.
- a variety of nutritional supplements may also be used as active ingredients including virtually any vitamin or mineral.
- Herbals are generally aromatic plants or plant parts and or extracts thereof that can be used medicinally or for flavoring. Suitable herbals can be used singly or in various mixtures. Commonly used herbs include Echinacea, Goldenseal, Calendula, Rosemary, Thyme, Kava Kava, Aloe, Blood Root, Grapefruit Seed Extract, Black Cohosh, Ginseng, Guarana, Cranberry, Gingko Biloba, St. John's Wort, Evening Primrose Oil, Yohimbe Bark, Green Tea, Ma Huang, Maca, Bilberry, Lutein, and combinations thereof.
- An effervescent system may include one or more edible acids and one or more edible alkaline materials.
- the edible acid(s) and the edible alkaline material(s) may react together to generate effervescence.
- the alkaline material(s) may be selected from, but is not limited to, alkali metal carbonates, alkali metal bicarbonates, alkaline earth metal carbonates, alkaline earth metal bicarbonates, and combinations thereof.
- the edible acid(s) may be selected from, but is not limited to, citric acid, phosphoric acid, tartaric acid, malic acid, ascorbic acid, and combinations thereof.
- an effervescing system may include one or more other ingredients such as, for example, carbon dioxide, oral care ingredients, flavorants, etc.
- Appetite suppressors can be ingredients such as fiber and protein that function to depress the desire to consume food.
- Appetite suppressors can also include benzphetamine, diethylpropion, mazindol, phendimetrazine, phentermine, hoodia (P57), Olibra,TM ephedra, caffeine and combinations thereof.
- Appetite suppressors are also known by the following trade names: Adipex,TM Adipost,TM BontrilTM PDM, BontrilTM Slow Release, Didrex,TM Fastin,TM Ionamin,TM Mazanor,TM Melf ⁇ at,TM Obenix,TM Phendiet,TM Phendiet-105,TM Phentercot,TM Phentride,TM Plegine,TM Prelu-2,TM Pro-Fast,TM PT 105,TM Sanorex,TM Tenuate,TM Sanorex,TM Tenuate,TM Tenuate Dospan,TM Tepanil Ten-Tab,TM Teramine,TM and Zantryl.TM These and other suitable appetite suppressors are further described in the following U.S.
- Micronutrients can include materials that have an impact on the nutritional well being of an organism even though the quantity required by the organism to have the desired effect is small relative to macronutrients such as protein, carbohydrate, and fat.
- Micronutrients can include, but are not limited to vitamins, minerals, enzymes, phytochemicals, antioxidants, and combinations thereof.
- vitamins can include fat soluble vitamins such as vitamin A, vitamin D, vitamin E, and vitamin K and combinations thereof.
- vitamins can include water soluble vitamins such as vitamin C (ascorbic acid), the B vitamins (thiamine or Bl, riboflavoin or B2, niacin or B3, pyridoxine or B6, folic acid or B9, cyanocobalimin or B 12, pantothenic acid, biotin), and combinations thereof.
- minerals can include but are not limited to sodium, magnesium, chromium, iodine, iron, manganese, calcium, copper, fluoride, potassium, phosphorous, molybdenum, selenium, zinc, and combinations thereof.
- micronutrients can include but are not limited to L- carnitine, choline, coenzyme QlO, alpha-lipoic acid, omega-3-fatty acids, pepsin, phytase, trypsin, lipases, proteases, cellulases, and combinations thereof.
- phytochemicals can include but are not limited to cartotenoids, chlorophyll, chlorophyllin, fiber, flavanoids, anthocyanins, cyaniding, delphinidin, malvidin, pelargonidin, peonidin, petunidin, flavanols, catechin, epicatechin, epigallocatechin, epigallocatechingallate (EGCG), theaflavins, thearubigins, proanthocyanins, flavonols, quercetin, kaempferol, myricetin, isorhamnetin, flavononeshesperetin, naringenin, eriodictyol, tangeretin, flavones, apigenin, luteolin, lignans, phytoestrogens, resveratrol, isoflavones, daidzein, genistein, glycitein, soy isoflavones, and
- Mouth moisteners can include, but are not limited to, saliva stimulators such as acids and salts and combinations thereof.
- acids can include acetic acid, adipic acid, ascorbic acid, butyric acid, citric acid, formic acid, fumaric acid, glyconic acid, lactic acid, phosphoric acid, malic acid, oxalic acid, succinic acid, tartaric acid and combinations thereof.
- salts can include sodium chloride, calcium chloride, potassium chloride, magnesium chloride, sea salt, sodium citrate, and combinations thereof.
- Mouth moisteners can also include hydrocolloid materials that hydrate and may adhere to oral surface to provide a sensation of mouth moistening.
- Hydrocolloid materials can include naturally occurring materials such as plant exudates, seed confectionerys, and seaweed extracts or they can be chemically modified materials such as cellulose, starch, or natural confectionery derivatives.
- hydrocolloid materials can include pectin, gum arabic, acacia gum, alginates, agar, carageenans, guar gum, xanthan gum, locust bean gum, gelatin, gellan gum, galactomannans, tragacanth gum, karaya gum, curdlan, konjac, chitosan, xyloglucan, beta glucan, furcellaran, gum ghatti, tamarin, bacterial gums, and combinations thereof.
- modified natural gums such as propylene glycol alginate, carboxymethyl locust bean gum, low methoxyl pectin, and their combinations can be included.
- modified celluloses can be included such as microcrystalline cellulose, carboxymethlcellulose (CMC), methylcellulose (MC), hydroxypropylmethylcellulose (HPCM), and hydroxypropylcellulose (MPC), and combinations thereof.
- humectants which can provide a perception of mouth hydration can be included.
- humectants can include, but are not limited to glycerol, sorbitol, polyethylene glycol, erythritol, and xylitol.
- fats can provide a perception of mouth moistening.
- Such fats can include medium chain triglycerides, vegetable oils, fish oils, mineral oils, and combinations thereof.
- Throat soothing ingredients can include analgesics, anesthetics, demulcents, antiseptic, and combinations thereof.
- analgesics/anesthetics can include menthol, phenol, hexylresorcinol, benzocaine, dyclonine hydrochloride, benzyl alcohol, salicyl alcohol, and combinations thereof.
- demulcents can include but are not limited to slippery elm bark, pectin, gelatin, and combinations thereof.
- antiseptic ingredients can include cetylpyridinium chloride, domiphen bromide, dequalinium chloride, and combinations thereof.
- antitussive ingredients such as chlophedianol hydrochloride, codeine, codeine phosphate, codeine sulfate, dextromethorphan, dextromethorphan hydrobromide, diphenhydramine citrate, and diphenhydramine hydrochloride, and combinations thereof can be included.
- throat soothing agents such as honey, propolis, aloe vera, glycerine, menthol and combinations thereof can be included.
- cough suppressants can be included.
- cough suppressants can fall into two groups: those that alter the consistency or production of phlegm such as mucolytics and expectorants; and those that suppress the coughing reflex such as codeine (narcotic cough suppressants), antihistamines, dextromethorphan and isoproterenol (non-narcotic cough suppressants).
- codeine narcotic cough suppressants
- antihistamines e.g., antihistamines
- dextromethorphan e.g., dextromethorphan
- isoproterenol non-narcotic cough suppressants
- antitussives can include, but are not limited to, the group consisting of codeine, dextromethorphan, dextrorphan, diphenhydramine, hydrocodone, noscapine, oxycodone, pentoxyverine and combinations thereof.
- antihistamines can include, but are not limited to, acrivastine, azatadine, brompheniramine, chlorpheniramine, clemastine, cyproheptadine, dexbrompheniramine, dimenhydrinate, diphenhydramine, doxylamine, hydroxyzine, meclizine, phenindamine, phenyltoloxamine, promethazine, pyrilamine, tripelennamine, triprolidine and combinations thereof.
- non-sedating antihistamines can include, but are not limited to, astemizole, cetirizine, ebastine, fexofenadine, loratidine, terfenadine, and combinations thereof.
- expectorants can include, but are not limited to, ammonium chloride, guaifenesin, ipecac fluid extract, potassium iodide and combinations thereof.
- mucolytics can include, but are not limited to, acetylcycsteine, ambroxol, bromhexine and combinations thereof.
- analgesic, antipyretic and anti-inflammatory agents can include, but are not limited to, acetaminophen, aspirin, diclofenac, diflunisal, etodolac, fenoprofen, flurbiprofen, ibuprofen, ketoprofen, ketorolac, nabumetone, naproxen, piroxicam, caffeine and mixtures thereof.
- local anesthetics can include, but are not limited to, lidocaine, benzocaine, phenol, dyclonine, benzonotate and mixtures thereof.
- nasal decongestants and ingredients that provide the perception of nasal clearing can be included.
- nasal decongestants can include but are not limited to phenylpropanolamine, pseudoephedrine, ephedrine, phenylephrine, oxymetazoline, and combinations thereof.
- ingredients that provide a perception of nasal clearing can include but are not limited to menthol, camphor, borneol, ephedrine, eucalyptus oil, peppermint oil, methyl salicylate, bornyl acetate, lavender oil, wasabi extracts, horseradish extracts, and combinations thereof.
- a perception of nasal clearing can be provided by odoriferous essential oils, extracts from woods, confectioneries, flowers and other botanicals, resins, animal secretions, and synthetic aromatic materials.
- optional or functional ingredients can include breath fresheners, dental care components, actives, herbals, effervescing systems, appetite suppressors, vitamins, micronutrients, mouth moistening components, throat care components, energy boosting agents, concentration boosting agents, and combinations thereof.
- the modified release component includes at least one ingredient selected from the group comprising flavors, sweeteners, sensates, breath fresheners, dental care components, actives, herbals, effervescing systems, appetite suppressors, potentiators, food acids, micronutrients, mouth moistening components, throat care components, and combinations thereof. These ingredients can be in encapsulated form, in free form, or both.
- ingredients may be added at various locations within the mixing process, be added at various times within the mixing process, be added at multiple locations within the mixing process, have various residence times within the mixing system, be exposed to various residence temperatures, be added at various weight percentages of the finished gum structure, be blended with other ingredients prior to being added to the mixing systems, and be added for various reasons.
- Some embodiments of gum structures and methods may include multiple ingredients from a single ingredient category, e.g. one gum structure may have several different elastomer ingredients.
- some methods and systems may add ingredients in varying orders.
- the filler may be added prior to an elastomer, while in another method the elastomer may be added prior to the filler.
- Some of the steps of forming gum structures may be performed at various physical locations or at various times. For example, it may be highly efficient to mass produce a first generic gum structure, also referred to as a "master batch", that may be less than a finished gum or finished gum base, at a central location or in mass quantity during a single production run (i.e. all at one time). Then, at a later time, the master batch is combined with the rest of the ingredients required to form a finished gum.
- the addition of the rest of the ingredients may occur at the same location or the master batch may be shipped to a remote processing plant where the finished gum is formed.
- Remote processing may occur, for example, when the final ingredients, which may form a substantial amount of the finished gum by weight percent, can be acquired and processed locally more easily, practically and inexpensively than shipping a completed finished gum or importing the finished composition due to various reasons.
- Large quantity production may occur, for example, when it is desired to form several finished gum compositions that are substantially similar gum structures except for a few ingredients, such as, for example, finished gums having slightly differing flavors or colors.
- Two typical forms of master batch include “gum base master batch” and “finished gum master batch.”
- a "gum base master batch”, as used herein is a gum composition that is not yet a finished gum base composition, but it includes some or most of the gum base ingredients for forming a finished gum base.
- a gum base master batch may be a set of gum base ingredients sufficient to form a finished gum based except for the desired amount of filler or emulsif ⁇ er.
- this set of gum base ingredients may include the elastomers, the plasticizers, and the fats, oils, and waxes required to form the desired finished gum base composition but is devoid of some or all of the necessary filler.
- this set of gum base ingredients may include the elastomers, the plasticizers, and the fillers required to form the desired finished gum base composition but is devoid of some or all of the necessary fats, oils, and waxes.
- a "finished gum master batch”, as used herein, is a gum composition that is not yet a finished gum composition, but it includes most of the gum base and subsequent gum ingredients necessary to from a finished gum.
- a finished gum master batch may be a set of gum base ingredients sufficient to form the desired gum base in combination with a set of subsequent gum ingredients that provides the desired sweeteners and potentiators but is devoid of the desired colorants and flavors.
- the production of a finished gum master batch can be desired in the same situation as discussed above, but for potential reasons such as that desired flavors, and corresponding colors, are very regional specific or much cheaper to obtain in a given region.
- Kitting can occur with gum base master batch as well.
- a gum base master batch may be formed that includes the elastomers, the plasticizers, and the fats, oils, and waxes required to form the desired finished gum base composition but is devoid of some or all of the necessary filler.
- This gum base master batch is then distributed to other locations where the requisite necessary filler is subsequently added to complete a finished gum base. This can be highly beneficial when the filler can be acquired at a cheaper rate at the remote location or it is cheaper to acquire the filler at the remote location rather than pay for the increased shipping costs, as filler can provide a large portion of the weight and volume of a finished gum base.
- kitting This production of a portion of a finished gum structure, i.e. a master batch, at one location and then finishing the finished gum at a local processing facility is one form of a process that can be referred to as kitting.
- kitting Another form of kitting is when a large mass production of a master batch is formed and then only a few differing ingredients are added to the master batch to form finished gum compositions, such as explained previously with regard to the finished gum master batch. Kitting occurs, where a large batch of a gum structure, e.g. a master batch, is mixed and then that master batch is then used as an ingredient in producing other gum structures, typically finished gums.
- Some forms of kitting include the formation of several master batches and then blending these master batches with or without additional ingredients at various ratios to form desired gum bases or finished gums. As such master batch itself can be considered an ingredient.
- Processing the ingredients to form gum structures can be performed by mixing the ingredients of the gum structures using many existing mixers known in the art.
- mixers including, but not limited to, static mixers, kettle mixers, sigma blade mixers, planetary mixers, Hobart mixers, Z-blade gum mixers, kneaders, single screw extruders, twin screw extruders, co-rotating twin-screw extruders, counter-rotating twin- screw extruders, reciprocating extruders, blade-and-pin mixers, etc.
- Other known mixers in the art that may suitably be used in practicing the systems and methods of the present invention are disclosed in previously cited patents that are incorporated in their entirety by reference.
- a mixer can be temperature controlled to maintain the residence temperature at a minimum, maximum or other desired level such as by being steam, cold fluid, or hot fluid jacketed, or otherwise heated or cooled.
- the term "residence temperature" as used herein will refer to the temperature of a composition while it is in a mixer or processing system at a given location or time. As such, a residence temperature may vary as the mixing process progresses either at different times/stages or at different locations of the mixer.
- Mixers may provide different types of mixing depending on the ingredients being mixed or the condition of the ingredients being mixed.
- Two primary types of mixing include distributive and dispersive mixing.
- Dispersive mixing is typically high shear mixing that breaks up individual ingredients and aggregations of ingredients within a composition into smaller pieces.
- Distributive mixing is typically lower shear mixing than distributive mixing and is used to distribute the individual ingredients throughout the composition to provide a more uniform composition. Dispersive and distributive mixing are more thoroughly described and discussed in U.S. Patent No. 5,562,936, the teachings and disclosure of which are hereby incorporated in their entireties by reference thereto.
- a continuous mixer which may also be referred to herein as a “continuous processor” is processing equipment in which the various ingredients used to prepare an effluent are fed substantially continuously into the device while those ingredients are being mixed and removed or ejected from the mixing system.
- ingredients are substantially continuously introduced through various upstream and downstream feed ports, all the while, the screws, blades, pins, paddles or other mixing elements continue to convey the mixture through the system, all the while mixing the same.
- the wholly or partly combined downstream portion of the mass is ejected from the extruder by the force of the mass substantially continually or continually being conveyed.
- the ejection of the mass from the extruder may be facilitated by inclusion of an external or supplemental pump.
- a continuous mixer may provide dispersive mixing, distributive mixing or a combination of both dispersive mixing and distributive mixing.
- a continuous mixer in the form of an extruder can have all dispersive mixing elements, all distributive mixing elements, or a combination of dispersive mixing elements and distributive mixing elements. Due to the characteristics and requirements of mixing gum compositions, the dispersive mixing elements are typically upstream of the distributive mixing elements, however, continuous mixers according to the present invention are not limited to that arrangement.
- a batch mixer which may also be referred to herein as a "batch processor" is processing equipment used to prepare a composition that once the composition is prepared the composition is ejected from the equipment all at once or at least discrete non-continuous portions of the composition will be ejected at intermittent intervals, but the composition is not continuously ejected during mixing.
- individual ingredients or portions of the individual ingredients used to prepare the composition are fed into the device substantially all at one time or in a predetermined temporal sequence in discrete amounts.
- Individual ingredients added to a batch mixer may be added at different times throughout the mixing cycle such that some ingredients have a residence time substantially equal to the entire length of the mixing cycle while other ingredients have a residence time for only a fraction of the entire length of the mixing cycle. Further, individual ingredients that are used for different purposes through out the mixing cycle may have different discrete portions of the ingredient added at different times throughout the mixing process. For example, one ingredient may be used to facilitate compounding elastomer as well as may be used as a bulking agent. Such an ingredient may have a first portion added at the beginning of the mixing cycle such that it has a residence time equal to the entire mixing time while a second portion of the same ingredient may be added later in the mixing cycle such that the second portion has a residence time less than the entire mixing time.
- a batch mixer will typically provide either dispersive mixing or distributive mixing, but usually not both dispersive and distributive mixing.
- a batch mixer used in practicing the present invention could be configured to provide both dispersive and distributive mixing.
- a kettle mixer that includes internal blades could be configured to shift between dispersive and distributive mixing by modifying the pitch or orientation of the blades.
- the kettle mixer could include multiple sets of blades, such that one set is configured for dispersive mixing while another set is configured for distributive mixing. It is contemplated the mixer would most likely only use on set of the blades at a time to provide one type of mixing at a time.
- FIG. 1 a first representative embodiment of a system 100 for use in mixing and processing gum structures is illustrated. This first system 100 will be explained in significant detail, while other embodiments illustrated in FIGS. 2-12, which are similar in many respects to system 100, will be discussed and described in more limited detail highlighting differences and similarities relative to system 100.
- System 100 includes three continuous mixers 102, 104, 106 arranged in series, which may comprise any of the aforementioned types of continuous mixers.
- the three continuous mixers 102, 104, 106 may provide varying levels or types of mixing ranging from high shear dispersive mixing to intermediate or low shear highly distributive mixing, and may even include mixing that is substantially free of shear.
- the first continuous mixer 102 is high shear or includes a high shear section. High shear may alternatively be employed in the second mixer, continuous mixer 104.
- High sear refers generally to the amount of shear force needed to masticate and compound elastomers.
- the continuous mixers 102, 104, 106 include a plurality of feed ports 121-126, 141-146, 161-166, respectively, at which various ingredients may be added to the mixers 102, 104, 106.
- Continuous mixers 102, 104, 106 are illustrated as each having six feed ports. However, continuous mixers used in practicing embodiments and methods of the present invention are not limited to or require any specific number of feed ports.
- the continuous mixers 102, 104, 106 may incorporate any known mixing elements such as high shear elements, low shear elements, kneading elements, neutral elements, high speed elements, low speed elements, etc.
- Ingredients may be stored, preferably in a readily available condition, prior to being added to a mixer in ingredient supplies, illustrated schematically in FIG. 1 and identified by reference numerals 131-138, 150-156, 171-173.
- ingredient supplies may include storage devices such as gravity flow bins or hoppers, liquid holding tanks or canisters, ingredient impermeable sacks, carts, trays, or other known applicable ingredient storage devices.
- the ingredients may be delivered from the ingredient supplies 131-138, 150- 156, 171-173 by appropriate ingredient handling systems (individual handling systems are shown schematically as a connecting arrow) such as augers, conveyor belts, side feeders, gravity flow, vacuum conveying systems, liquid pumping, etc.
- Ingredient handling systems may also incorporate optional blending devices, illustrated schematically and identified by reference numeral 139, such as blenders or low shear mixers.
- the blending device 139 mixes, also known as pre-blends, ingredients as the ingredients are being delivered from ingredient supplies.
- ingredient supplies 137, 138 supply ingredients to continuous mixers 102, but prior to being added to the continuous mixer 102.
- the ingredients from ingredient supplies 137, 138 may be mixed using mixer 139.
- a blending device is an optional device to provide some pre-blending and mixing of ingredients, the blending device is illustrated using dashed lines.
- the material handling systems will typically include metering devices such as load cells for monitoring the weight loss of a specific ingredient from a given ingredient supply.
- metering devices such as load cells for monitoring the weight loss of a specific ingredient from a given ingredient supply.
- flow metering devices that measure volume per unit of time may also be used.
- continuous mixers 102, 104, 106 are aligned generally in series. As such, continuous mixer 102 is upstream from continuous mixer 104 and the effluent of continuous mixer 102 is considered an ingredient added to continuous mixer 104, such as at feed port 141. Similarly, continuous mixer 104 is upstream of continuous mixer 106 and the effluent of continuous mixer 104 is considered an ingredient added to continuous mixer 106, such as at feed port 161.
- series will refer to both (a) the systems described above where the effluent of an upstream mixer is added as the first ingredient in a downstream mixer and (b) the system where the effluent of an upstream mixer is added to a downstream mixer in a downstream feed port.
- the effluent of continuous mixer 102 may be added to feed port 144 of continuous mixer 104 (illustrated by a dashed line arrow), rather than the first feed port 141 (illustrated as a solid line arrow), whilst other ingredients are being added to continuous mixer 104 upstream of feed port 144 such as to feed ports 141, 142 or 143.
- an individual mixer such as any one of continuous mixer 102, 104, 106, may comprise multiple mixers arranged in parallel (but nevertheless in series with the upstream or downstream mixers).
- the effluent of continuous mixer 106 will be a gum structure that will typically, but not always, be at least a gum base, something between a gum base and a finished gum, e.g. a gum base plus additional subsequent gum ingredients, or a finished gum, however other gum structure effluents are contemplated.
- the effluent is a finished gum, the effluent will be sent on to other gum finishing processes (not shown) including, but not limited to, forming, cooling/conditioning, coating, packaging, shipping, etc.
- the gum structure effluent of the first continuous mixer 102 is not a gum base, but may be something more or may be something less.
- continuous mixer 102 may be used for generally compounding elastomer ingredients such that the effluent of continuous mixer 102 is substantially a compounded elastomer, which may or may not include additional compounding aids.
- Compounding aids include, by way of example only, fillers, elastomer plasticizers, fats, waxes, resins or combinations thereof.
- Continuous mixer 102 compounds the elastomer to open up the elastomer matrix such that other ingredients, e.g. the water soluble flavoring or functional ingredients, of a finished gum can be carried by and then released over time as the finished gum is chewed.
- Each of the elastomer, filler and elastomer plasticizer can include a single ingredient from each category or can include a combination or combinations of several ingredients from each category of ingredients.
- the elastomer, filler and elastomer plasticizer may be fed into the continuous mixer 102 at separate feed ports 121-126 and in varying upstream and downstream arrangements.
- an elastomer ingredient may be fed from ingredient supply 130 to feed port 121 upstream from a filler that is fed from ingredient supply 131 to feed port 122.
- the filler may be fed from ingredient supply 130 to upstream feed port 130 while the elastomer is fed from ingredient supply 131 to downstream feed port 122 such that the filler is added upstream from the elastomer.
- This varied arrangement can be applied, where appropriate, to all ingredients added to any of the continuous mixers 102, 104, 106.
- multiple ingredients such as a filler and an elastomer plasticizer are fed into continuous mixer 102 substantially at the same location or feed port such as a filler may be fed from ingredient supply 132 to feed port 123 while an elastomer plasticizer may be fed from ingredient supply 134 also to feed port 123.
- Feed port 123 may be provided by one opening that allows multiple ingredients to be fed into the mixer or may include several openings that allow individual or multiple ingredients to be fed into the mixer at substantially equal locations.
- combinations of the elastomer, filler and/or plasticizer ingredients may be fed into the continuous mixer 102 as a pre-blended mix.
- one of the elastomer, filler and/or plasticizer may be fed from ingredient supply 137 while another one of the elastomer, filler and/or plasticizer may be fed from supply 138.
- the ingredients may be blended such as by an optional blender 139 or merely added together by the ingredient handling system such as an auger, side feeder, fluid flow pipe, a vacuum transporter, conveyor, etc. represented schematically by the connecting arrows.
- the addition of ingredients in the continuous mixer can occur at different feed ports so as to partially or wholly mix the ingredients added at a certain point prior to the addition of further ingredients. Also, by varying the location at which various ingredients are added, residence time, residence temperature and types of mixing of a relevant ingredients may be varied, which can be used to vary the characteristics of the gum structure produced by continuous mixer 102. By way of example only, modifying these feed and residence characteristics of individual ingredients can be used to vary the viscosity, texture and consistency of the material to alter the flowability of the composition through the continuous mixer.
- an individual ingredient supply for example feed supply 133 is not limited to storing ingredients for use in a single feed port.
- feed supply 133 can supply ingredient to both feed port 123 as well as feed port 124.
- a single feed supply may be used for feeding ingredients to multiple mixers.
- a single ingredient supply may include a plurality of individual temporary storage devices that may serve as a surge device and/or accumulator.
- a single feed supply could be provided by a plurality of bulk bins connected to a ingredient handling system. In this situation, when one of the storage devices runs empty, the other storage device can be used while filling the empty storage device.
- continuous mixer 102 will be configured for high-shear dispersive mixing. In most implementations, the high-shear dispersive mixing generates high temperatures within the mixer exposing the ingredients within the high-shear portions of the mixer 102 to high residence temperatures.
- the ingredients typically fed to continuous mixer 102 will be ingredients that are generally tolerant of high residence temperatures.
- the compounding of the elastomer may occur between a range of 125°F and an excess of 400 0 F. More typically, compounding residence temperatures will range between about of 225 0 F and 375°F.
- Cooling can be employed along mixer 102 if desired to facilitate attaining temperatures conducive to other ingredients to afford input of ingredients including water soluble ingredients. Portions of the mixer 102 can be independently cooled as compared to other portions.
- these ingredients will be exposed to further processing and mixing, e.g. via continuous mixers 104 and 106, these ingredients will also typically be tolerant of longer residence times within the mixing system.
- the ingredients added to continuous mixers, and particularly continuous mixer 102 may have typical residence times (i.e. average residence times) within continuous mixer 102 of between about 15 seconds and 5 minutes and more typically between about 30 seconds and 2 minutes. However, longer residence times within a continuous mixer are contemplated and may be up to or in excess of 15 minutes depending upon the mixer or gum structure.
- ingredients such as elastomer
- elastomer may be first pulverized or ground into chunks prior to being fed into any one of the feed ports 121-126 of continuous mixer 102.
- the elastomer ingredients can be fed to the continuous mixer 102 at ambient temperature in a flake, powder or chunk form and the shearing action of the continuous mixer 102 will stretch and heat the elastomer.
- the elastomer may be fed into the continuous mixer as a liquid, and in some embodiments a pre-heated liquid at a temperature of between about 160 0 F and 275°F.
- both liquid, powder and solid elastomers may be added to continuous processor 102.
- the entire weight percent of an ingredient is added at continuous mixer 102.
- only a portion of the total weight percent of an ingredient in the finished gum structure is added in continuous mixer 102, while another portion is added to either or both of continuous mixers 104 and 106.
- between about 10 to 90% by weight of the total filler added to a finished gum structure may be added at continuous mixer 102, more typically between about 25 to 75% by weight of the total filler added to a finished gum structure or even more typically about 35% to about 50% by weight of the total filler added to a finished gum structure while the remaining portion of the filler is added at other downstream mixers, e.g. continuous mixers 104, 106.
- Adding different weight percentages of a given ingredient at different portions of the ultimate mixing process can be particularly beneficial when kitting, as a lower weight and volume product can be produced and shipped. As such, the final portion of the total amount of the ingredient can be added later at other locations, such as filler. This can be advantageous when shipping product between facilities by lowering shipping costs and/or allowing for more practical, efficient or cheaper materials to be used at the local facility.
- the elastomer plasticizer is added downstream of the elastomer, such that the elastomer plasticizer is added to a feed port 122-126 that is downstream from another one of the feed ports 121-125 of continuous mixer 102.
- the elastomer plasticizer could be added to the same feed port such as feed port 123 as an elastomer, but be fed into the feed port downstream from the elastomer.
- the elastomer plasticizer could be fed into feed port 122 while the elastomer is fed into feed port 124.
- the elastomer plasticizer could be fed from supply 134 while the elastomer is fed from supply 132.
- both ingredients are fed to feed port 123.
- the elastomer plasticizer is added downstream of a first portion of elastomer, but upstream from another portion of the elastomer or a completely different elastomer.
- a first portion of the elastomer could be fed into feed port 121 from supply 130
- an elastomer plasticizer could be fed to feed port 122 from supply 131
- yet another portion or another elastomer could be fed from supply 136 into feed port 125.
- the elastomer plasticizer is added upstream of the elastomer to the same or another feed port.
- the elastomer plasticizer are exposed to a maximum residence temperature of approximately 210 0 F within continuous mixer 102 and more preferably a maximum residence temperature of about 200 0 F.
- ingredients that may be added to continuous mixer 102 include emulsif ⁇ ers, preservatives or stabilizing ingredients such as antioxidants.
- the effluent of continuous mixer 102 may be directly fed and added to continuous mixer 104.
- the effluent of continuous mixer 102 is as an ingredient added to continuous mixer 104.
- the product of continuous mixer 102 may be the first ingredient added to continuous mixer 104 at feed port 141 (illustrated by a solid connecting arrow). Alternatively, it may be added downstream relative to other ingredients that are added to upstream feed ports.
- the effluent of continuous mixer 102 could be added at feed port 144 (illustrated by the dashed connecting arrow), while other ingredients are added upstream at feed ports 140-143 of continuous mixer 104.
- the effluent of continuous mixer 102 could be diverted to an optional storage system 110, which may be in the form of a holding/surge tank, a recirculating circuit, a chiller/cooler, a forming processor such as to form a storable gum structure, such as in the form of pellets, bricks, agglomerated pellets (pellets in a brittle like form that have not completely separated from one another), or semi-viscous material so that the effluent can be stored until needed or shipped.
- a similar storage system could also be interposed additionally or alternatively between second mixer 104 and third mixer 106.
- antioxidants or other preservative ingredients are added to the gum structure formed in continuous processor 102. Addition of antioxidants or other preservatives may be particularly useful if the effluent is a master batch or used in kitting such that the effluent is stored for extended periods of time or shipped to other locations for further processing.
- Continuous mixer 104 is typically used for mixing the effluent of continuous mixer 102, e.g. generally compounded elastomer, with other ingredients to form a gum structure that will typically be a gum base, a gum base plus additional subsequent gum ingredients, or something short of a gum base that also includes subsequent gum ingredients, such as by adding, for example, additional plasticizers, fats, waxes and additional fillers. At this point, some flavors or sweeteners or other ingredients that effect the taste or intensity of the taste of the finished gum may be introduced.
- continuous mixer 104 is typically configured for lower shear mixing that is more distributive than continuous mixer 102.
- the residence temperatures of the composition as it progresses through continuous mixer 104 are typically lower than continuous mixer 102.
- Maximum residence temperatures (i.e. typical average residence temperatures) of continuous mixer 104 may reach 325°F, but are more typically below 250 0 F and even more preferably the residence temperatures vary between about 150 0 F and 225°F.
- more temperature sensitive ingredients may be fed to continuous mixer 104 with a lower risk of temperature induced degradation or ingredient loss resulting from flash-off.
- an otherwise temperature sensitive ingredient may be subjected to high temperatures beyond normal temperatures, if the length of exposure is very short.
- the lower temperature facilitates the addition of ingredients such as fats, waxes, fillers, sweeteners, plasticizers or syrups/fluids.
- ingredients such as fats, waxes, fillers, sweeteners, plasticizers or syrups/fluids.
- other ingredients that are not as temperature sensitive and that were previously added to the composition in continuous mixer 102 such as additional elastomers, elastomer plasticizers or fillers may also be added to continuous mixer 104.
- the ingredients added to continuous mixer 104 will have similar residence times as those ingredients added to continuous mixer 102.
- the short residence time within a continuous mixer can permit temperature sensitive ingredients that would otherwise not be added to a composition to be added to these mixers, because an ingredient may only be exposed to the high temperature for a very brief period of time, the high temperature has little to no degrading effects on the ingredient.
- ingredients such as colors, flavors, sensates and potentiators may also be added to the composition using continuous mixer 104.
- continuous mixer 104 typically colors and flavors will not be added or will be provided in only limited amounts to prevent adding limitations on the uses of the master batch in forming various different finished gum structures.
- the order of the addition of these additional ingredients can be varied to alter the flavor and texture of the product of continuous mixer 104. Further, as the residence temperatures within a continuous mixer fluctuate up and downstream, the temperature sensitive ingredients may be added at various locations so that the ingredients are not exposed to the high residence temperatures. In the event that the ingredients must be exposed to the high residence temperatures, the ingredients may be added at a location such that the ingredients are only exposed to the high residence temperature for a short period of time.
- continuous mixer 104 may include a cooler/chiller for cooling the composition prior to or while the temperature sensitive ingredient is being mixed and added. Further, a cooler/chiller may also be used to maintain the composition at a lower temperature after the ingredient has been added and mixed.
- the ingredients fed to continuous mixer 104 are generally fed using similar ingredient supplies and ingredient handling systems identified previously.
- the ingredient orientation may also be altered to provide a desired effluent.
- the effluent of continuous mixer 104 may be fed to continuous mixer 106 in a similar fashion as the effluent of continuous mixer 102 was fed to continuous mixer 104.
- the effluent may be fed directly into continuous mixer 106 such as the first ingredient at feed port 161 or as a downstream ingredient at feed port 164.
- the product could be diverted to a chiller/cooler, a holding tank, a recirculating circuit, or a finishing processor as discussed previously.
- Continuous mixer 106 can be used to finish the gum structure.
- the effluent of continuous mixer 106 may be at least a gum base, a gum base plus subsequent gum ingredients, or a finished gum.
- the ingredients mixed in continuous mixer may be fed from ingredient supplies 170-176 to feed ports 161-166 as discussed previously.
- An ingredient fed to continuous mixer 106 may be added to the composition in continuous mixer 106, rather than the earlier continuous mixers 102, 104 for such reasons the individual ingredient may be any one or any combination of highly sensitive to high temperatures, an expensive ingredient, required to be provided and distributed throughout the composition precisely or provided in very limited quantity.
- the ingredients added to continuous mixer 106 may includes, by way of example only, colors, flavors, sweeteners, sensates and functional ingredients.
- Continuous mixer 106 typically includes mixing elements that provide any and all of the following characteristics, low shear, low temperature and highly distributive mixing.
- the low temperature mixing of continuous mixer 106 is very suitable for the addition of highly temperature sensitive ingredients such as the flavors and sweeteners including both bulk sweeteners and high intensity sweeteners.
- the temperature of the composition as it flows through continuous mixer 106 is typically limited to below 150 0 F and more preferably below 130 0 F.
- Other ingredients such as, syrups/fluids, sensates, potentiators, acids, emulsifiers, color, functional ingredients would also typically be added in continuous mixer 106.
- the highly distributive mixing of continuous mixer 106 facilitates distribution of ingredients that provide a very limited weight percentage of the finished gum structure such that a substantially homogenous composition is formed. This can be very advantageous, particularly with active ingredients, where the ingredient needs to be distributed at an accurate concentration relative to the rest of the gum structure, such as where an individual stick of gum can and/or must have a very precise amount of ingredient. For example, such as gum that is used for medical reasons.
- the product of continuous mixer 106 will typically be a finished gum structure that is ready for finishing processes, such as forming, shaping, conditioning, coating, packaging, etc.
- the liquid ingredients added to individual continuous mixers 102, 104, 106 are added upstream of the dry ingredients.
- the dry ingredients may be added to the continuous mixers 102, 104, 106 upstream from the liquid ingredients.
- the dry and liquid ingredients may be interspersed relative to one another such that dry ingredients are added between upstream and downstream liquid ingredients and/or liquid ingredients are added between upstream and downstream dry ingredients.
- a system that uses a plurality of mixers to form gum structures.
- individual mixers can be highly configured for performing desired functions and are not limited to a single volume or movement speed input.
- a first mixer can be used for compounding the elastomer ingredients.
- the mixer can be configured for high shear and highly dispersive mixing.
- a second mixer can be more easily configured for low-shear and low temperature, highly distributive mixing for adding more temperature sensitive ingredients.
- the individual drive speeds and throughput of an individual mixer can be tailored to the mixing that it requires. This can reduce energy consumption and power required to drive the mixers.
- a continuous mixer that starts with raw materials and produces finished gum cannot be used when kitting gum structures to form finished gum. Further, when using multiple mixers for all gum production, consistency between different finished gum may be maintained because all gum may formed using similar systems, both, locally and remotely.
- FIG. 13 illustrates one example of a kitting system generally utilizing the system of FIG. 1.
- the first two continuous mixers 102, 104 are located at a first plant 112 while the third continuous mixer 106 is located at a second remote plant 114.
- the effluent of continuous mixer 104 may be formed and then packaged or otherwise prepared to be shipped by packaging system 116 which may include devices for pelletizing or forming bricks of the effluent of continuous mixer 104.
- the effluent is then shipped using shipping system 118 to the second plant 114 where it is used as an ingredient by continuous mixer 106.
- the effluent of continuous mixer 104 will typically be relatively standard in flavor profile and color.
- compositions at plant 114 may be added to mixer 106.
- additional fillers or bulking agents may be added to the gum structure. This is advantageous, as indicated previously, in reducing the volume and weight of product that is shipped to the remote second plant 114. Particularly, where the fillers, bulking agents, or other ingredients can be acquired cheaply at the location of the continuous mixer 106.
- FIG. 13 illustrates continuous mixers 102 and 104 at the first plant 112 and continuous mixer 106 at the second plant 114
- other configurations are clearly contemplated.
- continuous mixer 102 may be provided at the first plant 112 and the second two continuous mixers 104 and 106 may be provided at the second plant 114.
- continuous mixer 102 may be provided at a first plant
- continuous mixer 104 may be provided at a second plant
- continuous mixer 106 may be provided at a third plant.
- kitting system may be applied to the other embodiments disclosed in FIGS. 2-12.
- FIG. 2 illustrates an alternative system 200 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes two continuous mixers 202 and 204 and a batch mixer 206.
- continuous mixer 202 is upstream of continuous mixer 204, which is upstream of batch mixer 206.
- upstream continuous mixers 202, 204 function and operate much like continuous mixers 102, 104 discussed previously.
- Mixers 202, 204, 206 will typically receive similar ingredients as identified with respect to mixers 102, 104, 106, discussed previously.
- batch mixer 206 is used for producing the finished gum structure.
- continuous mixer 204 supplies its effluent to batch mixer 206 as an ingredient for only a portion of the mixing process.
- continuous mixers 202, 204 are either stopped or, preferably, the effluent of continuous mixer 204 is diverted to another location such as to an accumulator or a surge tank to temporarily hold the effluent of continuous mixer 204 while batch mixer 206 cycles through a batch.
- the mixer, accumulator or surge tank maintains the effluent of continuous mixer 204 at an elevated temperature, and preferably substantially as a fluid elevated above ambient such that the effluent can be pumped to batch mixer 206.
- the effluent of continuous mixer 204 can be diverted to a storage device 208 that uses a forming device such as a pelletizer or a brick molding system that forms storable effluent in pellets or bricks, respectively.
- a forming device such as a pelletizer or a brick molding system that forms storable effluent in pellets or bricks, respectively.
- the temperature of the effluent may significantly drop.
- the storage device 208 may be in the form of a system that further includes a heating or melting system for melting, or at least pre-heating, the pellets or bricks before they are added to batch mixer 206.
- a heating device may include bulk melting tanks, a continuous processor such as an extruder, or other well known devices for heating and melting the effluent.
- Pelletizing or molding bricks of the effluent of continuous mixer 204 is very advantageous when kitting, such as when the effluent must be shipped to another location.
- the effluent of continuous mixer 204 is added to batch mixer 206 for substantially the entire length of the mixing process. In other embodiments, the effluent of continuous mixer 204 is added to batch mixer 206 for only a short period of the mixing process. The effluent of continuous mixer 204 may be added to batch mixer 206 prior to any other ingredients, after other ingredients have been added or simultaneously as other ingredients are being added.
- the effluent of continuous mixer 204 may pass through a chiller/cooler prior to being added to batch mixer 206, such as when the effluent is fed directly to batch mixer 206. This is particularly beneficial when the effluent of continuous mixer 204 is significantly high that other ingredients added to batch mixer 204 would experience degradation.
- Ingredient supplies such as ingredient supplies 271, 272 for supplying ingredients to batch mixer 206 and corresponding ingredient handling systems are substantially similar to those identified previously and may be used to store and automatically supply ingredients to batch mixer 206. However, unlike continuous mixers, ingredients may be more easily manually added to batch mixer 206. Rather than the point of location being important, usually the timing and sequence of ingredient addition is more important in batch mixing.
- dry ingredients may be added to the batch mixer 206 prior to addition of any liquid or moist ingredients. This can be beneficial when one of the dry ingredients, such as a filler, being added to batch mixer 206 can be used to clean residue from a previous batch from the internal components of the batch mixer to prepare the batch mixer 206 for mixing a new batch of ingredients.
- Batch cycle times from the start and finish of mixing with batch mixer 206 may range between 2 minutes and 40 minutes and more preferably between about 10 minutes and 30 minutes. However, in some embodiments, individual ingredients have residence times less than the batch cycle time while other ingredients have residence times equal to the batch cycle time.
- the time of the mixing cycle at which ingredients are added to batch mixer 206 correlates in many respects as to the location at which an ingredient is added to a continuous mixer. For example, a new ingredient being added later in the mixing cycle of batch mixer 206 may be added at a later time to ensure that the previously added ingredients are adequately mixed prior to adding the new ingredient. Similarly, a new ingredient to be added to a composition using a continuous mixer may be added downstream from a plurality of ingredients so that the upstream ingredients are adequately processed and/or mixed prior to presenting the new ingredient.
- the batch mixer 206 may be heated or cooled to maintain the residence temperature of the ingredients during mixing.
- the heating or cooling may be varied depending on the particular period of the mixing cycle and the ingredients that are being mixed.
- FIG. 3 illustrates a further embodiment of a system 300 for processing and mixing ingredients to produce gum structures.
- This embodiment utilizes three mixers including a continuous mixer 302, a batch mixer 304 and a continuous mixer 306, with the continuous mixers 302, 306 upstream and downstream, respectively, of batch mixer 304.
- Continuous mixers 302 and 306 function substantially similar to continuous mixers 102 and 106 discussed previously.
- continuous mixer 302 supplies batch mixer 304 with sufficient effluent for the gum structure formed during one mixing cycle in batch mixer 304, continuous mixer 302 is shut down while it awaits batch mixer 304 to be emptied after each mixing cycle.
- the mixing system 300 includes a temporary storage device 308 to hold the effluent of continuous mixer 302 while 304 cycles through a batch.
- temporary storage device 308 may include a recirculating system, a surge tank or accumulator such that the effluent of continuous mixer 302 remains fluid and may include heaters to maintain the effluent at a temperature elevated above ambient.
- the temporary storage device 308 may pelletize or mold bricks of the effluent of continuous mixer 302 such that the effluent can be stored until needed by batch mixer 304.
- storage device 308 may further include a heating or melting device for raising the temperature of the effluent prior to adding it to the batch mixer 304.
- mixer 304 may be heated to melt the effluent prior to addition of other ingredients.
- batch mixer 304 may provide sufficient shear to generate enough heat to melt the bricks or pellets.
- batch mixer 304 Because batch mixer 304 generates periodic batches of gum structure effluent that are complete at the end of the mixing cycle, the entire batch is generally simultaneously expelled from batch mixer 304. By expelling all of the effluent of batch mixer 304, typically, more effluent is available for use by the downstream continuous mixer 306 than can be simultaneously fed into the continuous mixer 306. Particularly, because continuous mixer 306 is configured to be continuously fed ingredients, rather than fed a bulk quantity of ingredient that is greater than can be added directly to the continuous mixer 306.
- the effluent of batch mixer 304 typically must be pumped or otherwise transported to another storage device 312, which may take the form of a surge tank, storage bin, storage tank or forming device to form bricks or pellets to hold the excess effluent until it can be processed through continuous mixer 306.
- another storage device 312 may take the form of a surge tank, storage bin, storage tank or forming device to form bricks or pellets to hold the excess effluent until it can be processed through continuous mixer 306.
- a storage device of some type will typically be required between the batch mixer and the continuous mixer either to store the effluent of an upstream continuous mixer while the batch mixer is full and performing a mixing cycle or to hold the effluent of the batch mixer as it is progressively fed through a downstream continuous mixer.
- a batch mixer to batch mixer system such as between batch mixer 404 to batch mixer 406 in FIG. 4 does not typically require intermediate storage devices interposed between the batch mixers 404, 406. More particularly, effluent of batch mixer 404 may be expelled from batch mixer 404 and directly fed, manually or automatically, to batch mixer 406. However, in the circumstance where an upstream batch mixer, e.g. batch mixer 404, has a shorter batch cycle than a downstream batch mixer, e.g. batch mixer 406, a temporary storage device (not shown) may be utilized in between the two batch mixers 404, 406. [0276] Generally, system 400 operates and utilizes its continuous mixer 402 and batch mixers 404, 406 in a substantially similar manner as previously discussed continuous mixers and batch mixers.
- FIGS. 5-12 illustrate additional embodiments of systems for processing subsequent gum ingredients to produce finished gum. These systems may include two mixers such as the systems 500, 600, 1100 and 1200 illustrated in FIGS. 5, 6, 11 and 12, respectively, or three mixers such as systems 700-1000 illustrated in FIGS. 7-10, respectively.
- the functions of portions of two of the three mixers of the three mixer systems 100-400 and 700-1000 are performed by at least one of the mixers of the two mixer systems 500, 600, 1100 and 1200.
- system 500 may be configured such that continuous mixer 502 functions substantially similar to mixer 102 discussed previously and continuous mixer 504 combines the mixing elements of continuous mixers 104 and 106 of system 100 to perform the similar functions.
- continuous mixer 502 includes primarily high shear, high temperature mixing and the effluent of mixer 502.
- the ingredients added to continuous mixer 502 at feed ports 521-526 from ingredient supplies 530-533 may be elastomers, and potentially some compounding aids such as fillers and elastomer plasticizers.
- the effluent from continuous mixer 502 may be substantially only a compounded elastomer, with or without some compounding aids.
- Continuous mixer 504 will be configured for lower shear and lower temperature mixing. As such, continuous mixer 504 will be fed the rest of the ingredients to form the desired gum structure from ingredient supplies 550-555 at various feed ports 541-546.
- ingredients such as flavors, sweeteners, colors, emulsif ⁇ ers, fats, waxes will typically be added to the composition in continuous mixer 504. Additional portions of fillers and ingredients used to compound the elastomer may also added to the composition in continuous mixer 504.
- the gum structure effluent of continuous mixer 502 may be substantially more than a compounded elastomer.
- continuous mixer 502 will be fed elastomers, fillers, preservatives, resins, emulsif ⁇ ers, elastomer plasticizers, plasticizers, fats, waxes, and/or some initial colors or flavors.
- continuous mixer 502 will typically include both high shear and low shear mixing elements.
- the mixing elements of continuous mixer 502 proximate feed ports 521-523 may be similar to the mixing elements of continuous mixer 102, while downstream mixing elements proximate feed ports 524-526 may be intermediate or low shear similar to the mixing elements of continuous mixer 104.
- a portion of continuous mixer 502 will preferably be, at least partially, cold fluid jacketed or include an intermediate cooling section so as to attempt to reduce the temperature of the composition as it passes through continuous mixer 502.
- the cold fluid jacket or cooling sections are positioned prior to the location where the more temperature sensitive ingredients, e.g. sweeteners or flavors, are added.
- the portion of continuous mixer proximate feed ports 524-526 may be cold fluid jacketed or a cooling section may be provided between feed ports 523 and 524.
- the portion of continuous mixer 502 proximate feed ports 521-523 may be warm fluid or steam jacketed to maintain the proper temperature for compounding the elastomer.
- FIG. 6 illustrates a system 600 that includes a continuous mixer 602 upstream of a batch mixer 604.
- This system 600 is similar to system 500 because it includes two mixers.
- continuous mixer 602 functions much like continuous mixer 502 and may be used for the limited purpose of compounding the elastomer or in other embodiments continuous mixer 502 may be used for producing much more than a compounded elastomer.
- the rest of the ingredients required to finish the desired gum structure are then added to the composition at batch mixer 604.
- system 600 has continuous mixer 602 upstream and feeding batch mixer 604, some embodiments may include a storage device 608, which may be implemented or include such devices as discussed previously.
- FIG. 7 illustrates a further embodiment of a system 700 for mixing and processing ingredients to form gum structures.
- This embodiment includes three batch mixers 702, 704, 706 aligned in series.
- the effluent of batch mixer 702 is added to batch mixer 704 as an ingredient and the effluent of batch mixer 704 is added to batch mixer 706 as an ingredient.
- batch mixers 702, 704, 706 have similar shear characteristics as continuous mixers 102, 104, 106, respectively.
- the order in which ingredients are mixed using batch mixers 702, 704, 706 is dependent upon the time at which an individual ingredient is added to the batch mixers 702, 704, 706 during the mixing cycle.
- a portion of dry filler may be added to the batch mixers 702, 704, 706 to assist in cleaning or preparing the internal components of the batch mixers 702, 704, 706 for a new batch prior to adding other ingredients, particularly liquid ingredients.
- FIGS. 8-12 illustrate additional representative systems for mixing and processing ingredients to form gum structures. The understanding and operation of these additional systems can be understood from the description of the previous embodiments of systems 100-700.
- FIG. 8 illustrates an alternative system 800 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes two batch mixers 802 and 804 and a continuous mixer 806 in series, respectively.
- batch mixer 802 is upstream of batch mixer 804, which is upstream of continuous mixer 806.
- System will typically include a temporary storage device 808 to hold the excess effluent from batch mixer 804 while the effluent is waiting to be processed through continuous mixer 806.
- the individual mixers will function in a similar manner as discussed previously. Further, the system may incorporate similar features such as cooling devices and ingredient supply and handling systems as discussed previously.
- FIG. 9 illustrates an alternative system 900 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes a first batch mixer 902, a continuous mixer 904 and a second batch mixer 906 arranged in series, respectively.
- batch mixer 902 is upstream of continuous mixer 904, which is upstream of batch mixer 906.
- the system 900 will include a first temporary storage device 908 for storing the batch of effluent from batch mixer 902 while it is being fed into continuous mixer 904.
- system 900 will incorporate a temporary storage device 912 between the continuous mixer 904 and the batch mixer to store the effluent from continuous mixer 904 while batch mixer 906 processes a batch.
- the individual mixers will function in a similar manner as discussed previously. Further, the system may incorporate similar features such as cooling devices and ingredient supply and handling systems as discussed previously.
- FIG. 10 illustrates an alternative system 1000 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes a batch mixer and two continuous mixers 1004, 1006 arranged in series, respectively.
- batch mixer 1002 is upstream of continuous mixer 1004, which is upstream of continuous mixer 1006.
- the system 1000 will typically incorporate a temporary storage device 1008, as described previously.
- the individual mixers will function in a similar manner as discussed previously. Further, the system may incorporate similar features such as cooling devices and ingredient supply and handling systems as discussed previously.
- FIG. 11 illustrates an alternative system 1100 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes a batch mixer 1102 and a continuous mixer 1104 arranged in series, respectively.
- batch mixer 1102 is upstream of batch mixer 1104.
- the individual mixers will function in a similar manner as discussed previously.
- the system 1100 will typically incorporate a temporary storage device 1108, as described previously.
- the individual mixers will function in a similar manner as discussed previously. Further, the system may incorporate similar features such as cooling devices and ingredient supply and handling systems as discussed previously.
- FIG. 12 illustrates an alternative system 1200 for processing and mixing various combinations of ingredients to form gum structures.
- This system includes two batch mixers 1202 and 1204 arranged in series, respectively.
- batch mixer 802 is upstream of batch mixer 804.
- the individual mixers will function in a similar manner as discussed previously. Further, the system may incorporate similar features such as cooling, temporary storage devices and ingredient supply and handling system as discussed previously.
- Table 1 begins by illustrating a general break down of representative weight percentages of various ingredients, by broad category, that are typically, but not always, employed in finished gum structures.
- Table 2 illustrates a few examples of representative finished gum bases that can be used in finished gum compositions. More particularly, Table 2 illustrates representative gum base ingredients illustrated by weight percents of a contemplated finished gum base. These, and other, gum bases can be formed using the mixing systems 100-1200 discussed previously.
- Table 3 illustrates a few examples of representative finished gums. More particularly, Table 3 illustrates representative finished gum structures that incorporate at least one of the finished gum base structures of Table 2. These finished gum structures additionally incorporate subsequent gum ingredients to form finished gum structures. The ingredients are listed by way of weight percent of the finished gum composition. These, and other, finished gum structures can be formed using the mixing systems 100-1200 discussed previously.
- Table 4 expands on Tables 1, 2 and 3 by illustrating contemplated processes and individual steps for generally mixing and adding the ingredients identified in Tables 1 , 2 and 3 using mixing systems and methods according to the present invention. In doing so, Table 4 provides an overarching map of potential types of effluents, i.e. intermediate and final gum structures, from the various mixers in the mixing systems 100-1200 discussed previously.
- Mixer 1 generally corresponds to the first mixer in the series of mixers of the previously discussed mixing systems 100-1200 (i.e. the mixer in a given system having a reference numeral ending in "02").
- mixer 2 corresponds to the second mixer in the series of mixers of the previously discussed mixing systems 100-1200 (i.e. the mixer in a given system having the reference numeral ending in "04").
- Downstream mixing is contemplated to be performed by the third mixer (i.e. the mixer in a given system having a reference numeral ending in "06") in the previously discussed mixing systems that include three mixers.
- FG is a finished/complete gum product including a finished gum base (FGB) and a finished set of subsequent gum ingredients (FSGI), but that has not yet been rolled, scored, formed, conditioned, coated or exposed to other post mixing processes.
- FGB finished gum base
- FSGI finished set of subsequent gum ingredients
- FGB is set of gum base ingredients (GBI X ) forming a finished gum base.
- FGBs may vary such that not all FGBs are the same.
- Table 2, provided above, illustrates compositional examples of several contemplated FGBs. As illustrated by the FGBs of Examples 1 and 3 of Table 2, it is clear that an FGB can have different ingredients within an ingredient category, e.g. Example 1 uses Butyl Rubber while Example 3 does not use any Butyl Rubber but instead uses Styrene -butadiene Rubber. Further, Examples 1 and 3 illustrate that a specific ingredient can be used in different rations. For example, the FGB of Example 1 uses between 5-15 by weight percent PVA, while Example 3 uses between 15-25 by weight percent PVA.
- FSGI is a set of subsequent gum ingredients (SGIx), not including gum base or coating ingredients, in a finished gum product, also referred to herein as a "finished set of subsequent gum ingredients".
- SGIx subsequent gum ingredients
- FSGIs may vary such that not all FSGIs are the same. Generally, these ingredients form the water soluble portion of a gum structure.
- the set of subsequent gum ingredients identified in Examples 6-10 of Table 3 illustrate several contemplated representative FSGIs.
- the FSGI of Example 6 identified above includes a desired combination of bulk sweeteners, high intensity sweeteners, encapsulated sweeteners, fluids, emulsif ⁇ ers, flavor, acids and colors.
- Example 7 is an FSGI that is different than Example 6 and fails to include any encapsulated sweeteners.
- GBIx is a set of gum base ingredients that does not include subsequent gum ingredients. GBIxs may vary such that not all GBIxs are the same. When used in Table 4, a GBIx is less than a finished gum base. However, a GBIx in one gum structure may be a FGB of another gum structure. For example, a first GBIx for a first gum structure or process may merely be elastomer, while a second GBIx for a second gum structure or process may include elastomer, plasticizer, fats, waxes, oils, filler and softeners. In this second example, the set of ingredients is not sufficient to form a FGB for the desired gum structure, but may be sufficient to form an FGB for a different gum structure.
- a “set” may include one or more ingredients. As such, a “set”, as used herein and above, need not include multiple ingredients.
- GBIxy is a GBIx effluent or portion of an effluent from an upstream mixer plus at least one additional gum base ingredient GBIy.
- a GBIxy is less than a finished gum base.
- GBIxys may vary such that not all GBIxys are the same.
- a GBIxy in one gum structure may be a GBIx of another gum structure.
- a GBIxy may be the combination of the same ingredient added in two different mixers.
- a GBIxy may be generated by adding a first portion of filler (GBIx) in a first mixer and then adding a second portion of the same exact type of filler (GBIy) in a second mixer to form a GBIxy in the second mixer that is formed entirely of a single ingredient
- a GBIxy of a first gum structure or process may be the combination of an elastomer (GBIx) added in an upstream mixer and a plasticizer (GBIy) added in a downstream mixer.
- GBIxyz is a GBIxy effluent or portion of an effluent from an upstream mixer plus at least one additional gum base ingredient GBIz.
- a GBIxyz is less than a finished gum base.
- GBIxyzs may vary such that not all GBIxyzs are the same.
- SGIx is a set of subsequent gum ingredients that not including gum base or coating ingredients. SGIxs may vary such that not all SGIxs are the same. When used in Table 4, a SGIx is less than a finished set of gum ingredients. Further, a SGIx in one gum structure may be a FSGI of another gum structure. For example, a first SGIx for a first gum structure or process may merely be bulk sweeteners, while a second SGIx for a second gum structure or process may include bulk sweeteners, encapsulated sweeteners, high intensity sweeteners as well as flavors.
- SGIxy is a SGIx effluent or portion of an effluent from an upstream mixer plus at least one additional gum ingredient SGIy (but is not yet a FSGI).
- SGIxys may vary such that not all SGIxys are the same. When used in Table 4, a SGIxy is less than a finished set of gum ingredients. Further, a SGIxy may be the combination of the same ingredient added in two different mixers.
- a SGIxy may be generated by adding a first portion of the bulk sweetener (SGIx) in an upstream mixer and then adding a second portion of the same exact bulk sweetener (SGIy) n a second mixer to form a SGIxy in the second mixer formed entirely of a single ingredient.
- a SGIxy of a first gum structure or process may be the combination of a bulk sweetener (SGIx) in an upstream mixer and the addition of an encapsulated sweetener (SGIy) in a downstream mixer.
- SGIxyz is a SGIxy effluent or portion of an effluent from an upstream mixer plus at least one additional gum ingredient SGIz (but is not yet a FSGI). SGIxyzs may vary such that not all SGIxyzs are the same. When used in Table 4, a SGIxyz is less than a finished set of gum ingredients.
- a portion of each of the sets of gum base ingredients could include some if not all of the same category of ingredients as the previously added set of gum base ingredients. For example, if elastomer is added in GBIx more of the same elastomer and/or an additional elastomer could be added in GBIy or GBIz. Additionally, in a given process a GBIx, GBIy and/or GBIz could be finished gum bases such that the process mixes individual finished gum bases together to form a new desired gum base such as in kitting as discussed previously.
- all of the ingredients of a SGIxy or SGIxyz could include the ingredients of a SGIx of another mixing process.
- a portion of each of the sets of subsequent gum ingredients could include some if not all of the same category of ingredients as the previously added set of subsequent gum ingredients. For example, if a bulk sweetener is added in SGIx more of the same bulk sweetener and/or an additional bulk sweetener could be added in SGIy or SGIz.
- Processes 1-7 represent mixing processes where the effluent of mixer 1 is a set of gum base ingredients (GB I x s) that does not yet form a gum base.
- GB I x of mixer 1 could be an elastomer in combination with one or more compounding aids such as a filler and/or an elastomer plasticizer.
- the effluent of mixer 1 is added to mixer 2 as an ingredient and added to another set of gum base ingredients, namely GBIy, to form a set of gum base ingredients GBIxy, which is not yet a finished gum base.
- GBIy could be an additional elastomer, more filler, or other GBI identified in Table 3.
- GBIz Another set of gum base ingredients GBIz, only, could be added to effluent GBIxy to form a gum structure that is either a finished gum base (FGB) or a set of gum base ingredients that does not yet form a FGB (GBIxyz).
- a first set of subsequent gum ingredients, SGIx could be added to the effluent of mixer 2 to form a gum structure that is a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIxy+SGIx) or a finished set of subsequent gum ingredients (GBIxy+FSGI).
- another set of gum base ingredients GBIz and a set of subsequent gum ingredients could be added to effluent GBIxy to form a gum structure that is either a finished gum base plus some subsequent gum ingredients that do not form a finished set of subsequent gum ingredients (FGB+SGIx); a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients (GBIxyz+SGIx); a set of gum base ingredients that is less than a finished gum base but includes a finished set of subsequent gum ingredients (GBIxyz+FSGI); or forms a finished gum product (FG) that includes both a finished gum base and a finished set of subsequent gum ingredients.
- GBIz and a set of subsequent gum ingredients SGIx
- Process 2 is similar to Example 1 in that only gum base ingredients are added to effluent GBIx of mixer 1. However, in this embodiment, the additional gum base ingredients add to effluent GBIx in mixer 2 are sufficient to form a finished gum base (FGB). As the effluent FGB of mixer 2 includes all of the gum base ingredients necessary for the contemplated gum structure, no more gum base ingredients will typically be added in downstream mixing. Thus, potential options for downstream mixing are limited to adding a set of subsequent gum ingredients SGIx. The set of subsequent gum ingredients SGIx may be a finished set of subsequent gum ingredients FSGI such that the effluent of continuous mixer is a finished gum composition (FG).
- FG finished gum composition
- the set of subsequent gum ingredients SGIx may be less than a finished set of subsequent gum ingredients such that the effluent of the down stream mixing is a finished gum base in combination with some subsequent gum ingredients that is not yet a finished gum composition (FGB+SGIx).
- FGB+SGIx a finished gum composition
- This second option would be subjected to further processing by a secondary system. This could occur such as when kitting occurs and the final ingredient set that may be added may be some bulking agents such as bulk sweeteners at a local plant.
- Process 3 adds a set of subsequent gum ingredients SGIx that is not yet a finished set of subsequent gum ingredients (FSGI) to the effluent GBIx of mixer 1 to form effluent GBIx+SGIx of mixer 2. Numerous downstream mixing options occur for effluent GBIx+SGIx of mixer 2.
- An additional set of gum base ingredients GBIy may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base, but is closer to a FGB, or a finished set of subsequent gum ingredients (GBIxy+SGIx) or a finished gum base plus a set a subsequent gum ingredients that does not yet form a finished set of subsequent gum ingredients (FGB+SGIx).
- an additional set of subsequent gum ingredients SGIy may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base or a finished set of subsequent gum ingredients, but is closer to a FSGI, (GBIx+SGIxy) or a finished set of subsequent gum ingredients plus a set a gum base ingredients that does not yet form a finished gum base (GBIx+FSGI).
- GBIy and another set of subsequent gum ingredients SGIy could be added to effluent GBIx+SGIx to form either a gum structure that is of a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI, but is closer to a FGB and FSGI, (GBIxy+SGIxy); a gum structure that includes a finished gum base plus a set of subsequent gum ingredients that is less than a FSGI (FGB+SGIxy); a gum structure that is less than a gum base plus a finished set of subsequent gum ingredients (GBIxy+FSGI); or a finished gum composition (FG).
- GBIy and another set of subsequent gum ingredients SGIy could be added to effluent GBIx+SGIx to form either a gum structure that is of a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI, but is closer to a FGB and FSGI, (GBIxy+SGIxy); a
- Process 4 adds an additional set of gum base ingredients GBIy and a set of subsequent gum ingredients SGIx to effluent GBIx of mixer 1.
- the gum structure effluent GBIxy+SGIx of mixer 2 is less than a FGB or a FSGI.
- Numerous downstream mixing options occur for effluent GBIxy+SGIx of mixer 2.
- An additional set of gum base ingredients GBIz may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIxyz+SGIx); or a finished gum base plus a set a subsequent gum ingredients that does not yet form a finished set of subsequent gum ingredients (FGB+SGIx).
- an additional set of subsequent gum ingredients SGIy may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base or a finished set of subsequent gum ingredients (GBIxy+SGIxy); or a finished set of subsequent gum ingredients plus a set a gum base ingredients that does not yet form a finished gum base (GBIxy+FSGI).
- another set of gum base ingredients GBIz and another set of subsequent gum ingredients SGIy could be added to effluent GBIxy+SGIx to form either a gum structure that is of a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI (GBIxyz+SGIxy); a gum structure that includes a finished gum base plus a set of subsequent gum ingredients that is less than a FSGI (FGB+SGIxy); a gum structure that is less than a gum base plus a finished set of subsequent gum ingredients (GBIxyz+FSGI); or a finished gum composition (FG).
- GBIz and another set of subsequent gum ingredients SGIy could be added to effluent GBIxy+SGIx to form either a gum structure that is of a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI (GBIxyz+SGIxy); a gum structure that includes a finished gum base plus a set of subsequent gum ingredients
- Process 5 adds a set of subsequent gum ingredients SGIx to mixer 2 that is a finished set of subsequent gum ingredients to effluent GBIx of mixer 1.
- the subsequent gum ingredients added to effluent GBIx in mixer 2 are sufficient to form a finished set of subsequent gum ingredients.
- effluent GBIx+FSGI of mixer 2 includes all of the subsequent gum ingredients necessary for a contemplated gum structure, no more subsequent gum ingredients will typically be added in downstream mixing.
- potential options for downstream mixing are limited to adding a set of gum base ingredients GBIy.
- the set of gum base ingredients GBIy may finish the set of gum base ingredients such that the effluent of continuous mixer is a finished gum composition (FG).
- the set of gum base ingredients GBIy may be less than a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients in combination with some gum base ingredients that are not yet a finished gum base (GBIxy+FSGI).
- Process 6 adds an additional set of gum base ingredients GBIy and a set of subsequent gum ingredients SGIx to mixer 2 that is a finished set of subsequent gum ingredients to effluent GBIx of mixer 1.
- the set of gum base ingredients GBIy add to effluent GBIx in mixer 2 is not sufficient to form a finished gum base.
- effluent GBIxy+FSGI of mixer 2 includes all of the subsequent gum ingredients necessary for a contemplated gum structure, no more subsequent gum ingredients will typically be added in downstream mixing.
- potential options for downstream mixing are limited to adding a set of gum base ingredients GBIz.
- the set of gum base ingredients GBIz may finish the set of gum base ingredients such that the effluent of continuous mixer is a finished gum composition (FG).
- the set of gum base ingredients GBIz in combination with the previously added gum base ingredients GBIxy may be less than a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients in combination with some gum base ingredients that are not yet a finished gum base (GBIxyz+FSGI).
- Process 7 adds an additional set of gum base ingredients GBIy and a set of subsequent gum ingredients SGIx to effluent GBIx of continuous mixer 502.
- the additional set of gum base ingredients GBIy is sufficient to form finished gum base and the set of subsequent gum ingredients SGIx is sufficient to form a finished set of subsequent gum ingredients.
- the effluent of continuous mixer 504 is a finished gum composition (FG). No further gum base or subsequent gum ingredients are typically added to the effluent of continuous mixer 504 and thus only two mixers are required for this embodiment.
- Process 8-14 represent mixing processes where the effluent of mixer 1, such as mixer 102, 502 of mixing system 100, 500, is a set of subsequent gum ingredients (SGIxs) that does not yet form a finished set of subsequent gum ingredients (FSGI).
- SGIxs subsequent gum ingredients
- the effluent of mixer 1 is added to mixer 2 as an ingredient and added to another set of subsequent gum ingredients, namely SGIy, to form a set of subsequent gum ingredients SGIxy, which is not yet a finished set of subsequent gum ingredients.
- SGIxy a set of subsequent gum ingredients
- Another set of subsequent gum ingredients SGIz could be added to effluent SGIxy to form a gum structure that is either a finished set of subsequent gum ingredients (FSGI) or a set of subsequent gum ingredients that does not yet form a finished set of subsequent gum ingredients (SGIxyz).
- a set of gum base ingredients GBIx could be added to the effluent of mixer 2 to form a gum structure that is a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a FGB or FSGI (GBIx+SGIxy) or a finished gum base plus a set of subsequent gum ingredients that does not yet form a FSGI (FGB+SGIxy).
- another set of subsequent gum ingredients SGIz and a set of gum base ingredients GBIx could be added to effluent SGIxy to form a gum structure that is either a finished gum base plus some subsequent gum ingredients that do not form a finished set of subsequent gum ingredients (FGB+SGIxyz); a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients (GBIx+SGIxyz); a set of gum base ingredients that is less than a finished gum base but includes a finished set of subsequent gum ingredients (GBIxyz+FSGI); or a finished gum product (FG) that includes both a finished gum base and a finished set of subsequent gum ingredients.
- FGB+SGIxyz a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients
- FG finished gum product
- the effluent of continuous mixer 104 is an SGIxy and therefore is complete subsequent gum ingredients.
- this SGIxy may be added to continuous mixer 106 at feed port 164 and the gum base ingredients GBIx may be added at an upstream feed port such as feed port 162.
- the gum base ingredients can be compounded and then exposed to a cooling device or process prior to being mixed with the SGIxy.
- Process 9 is similar to Example 8 in that only subsequent gum ingredients are added to effluent SGIx of mixer 1. However, in this embodiment, the additional set of subsequent gum ingredients add to effluent SGIx in mixer 2 is sufficient to form a finished set of subsequent gum ingredients (FSGI). As the effluent FSGI of mixer 2 includes all of the subsequent gum ingredients necessary for the contemplated gum structure, no more subsequent gum ingredients will typically be added in downstream mixing. Thus, potential options for downstream mixing are limited to adding a set of gum base ingredients GBIx.
- the set of gum base ingredients GBIx may be a finished gum base FGB such that the effluent of continuous mixer is a finished gum composition (FG).
- the set of gum base ingredients GBIx may be less than a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients in combination with at least one gum base ingredient that is not yet a FGB (GBIx+FSGI).
- GBIx+FSGI a finished gum base ingredient that is not yet a FGB
- This second option would be subjected to further processing by a secondary system. This could occur such as when kitting occurs and the final ingredient set that may be added may be some bulking agents such as additional filler or if additional plasticizers are needed.
- Process 10 adds a set of gum base ingredients GBIx that is not yet a finished gum base (FGB) to the effluent SGIx of mixer 1 to form effluent GBIx+SGIx of mixer 2.
- the downstream mixing options for this example are identical as the downstream mixing options for Process 3.
- Process 11 adds an additional set of subsequent gum ingredients SGIy and a set of gum base ingredients GBIx to effluent SGIx of mixer 1.
- the gum structure effluent GBIx+SGIxy of mixer 2 is less than a FGB or a FSGI.
- Numerous downstream mixing options occur for effluent GBIx+SGIxy of mixer 2.
- An additional set of gum base ingredients GBIy may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIxy+SGIxy); or a finished gum base plus a set a subsequent gum ingredients that does not yet form a finished set of subsequent gum ingredients (FGB+SGIxy).
- an additional set of subsequent gum ingredients SGIz may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base or a finished set of subsequent gum ingredients (GBIx+SGIxyz); or a finished set of subsequent gum ingredients plus a set a gum base ingredients that does not yet form a finished gum base (GBIxy+FSGI).
- another set of gum base ingredients GBIy and another set of subsequent gum ingredients SGIz could be added to effluent GBIx+SGIxy to form either a gum structure that is a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI (GBIxy+SGIxyz); a gum structure that includes a finished gum base plus a set of subsequent gum ingredients that is less than a FSGI (FGB+SGIxyz); a gum structure that is less than a gum base plus a finished set of subsequent gum ingredients (GBIxy+FSGI); or a finished gum composition (FG).
- Process 12 adds a set of gum base ingredients GBIx to mixer 2 that is a finished gum base to effluent SGIx of mixer 1.
- effluent FGB+SGIx of mixer 2 includes a finished gum base, no more gum base ingredients will typically be added in downstream mixing.
- potential options for downstream mixing are limited to adding a set of subsequent gum ingredients SGIy.
- the set of subsequent gum ingredients SGIy may finish the set of subsequent gum ingredients such that the effluent of continuous mixer is a finished gum composition (FG).
- the set of subsequent gum ingredients SGIy in combination with the previously added subsequent gum ingredients may not form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum base in combination with less than a finished set of subsequent gum ingredients (FGB+SGIxy).
- Process 13 adds an additional set of subsequent gum ingredients SGIy and a set of gum base ingredients GBIx to mixer 2 that is a finished gum base to effluent SGIx of mixer 1.
- effluent FGB+SGIxy of mixer 2 includes a finished gum base, no more gum base ingredients will typically be added in downstream mixing.
- potential options for downstream mixing are limited to adding a set of subsequent gum ingredients SGIz.
- the set of subsequent gum ingredients SGIz in combination with subsequent gum ingredients SGIxy may finish the set of subsequent gum ingredients such that the effluent of continuous mixer is a finished gum composition (FG).
- the set of subsequent gum ingredients SGIz in combination with the previously added subsequent gum ingredients SGIxy may not form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum base in combination with less than a finished set of subsequent gum ingredients (FGB+SGIxyz).
- Process 14 adds a set of gum base ingredients GBIx and an additional set of subsequent gum ingredients SGIy to effluent SGIx of continuous mixer 502.
- the set of gum base ingredients GBIx is sufficient to form a finished gum base and the additional set of subsequent gum ingredients SGIy is sufficient to form a finished set of subsequent gum ingredients.
- the effluent of continuous mixer 504 is a finished gum composition (FG). No further gum base or subsequent gum ingredients are typically added to the effluent of continuous mixer 504 and thus only two mixers are required for this embodiment.
- Process 15-22 represent mixing processes where the effluent of mixer 1, such as mixer 102, 502 of mixing system 100, 500, respectively, is a set of gum base ingredients (GBIx) that is less than a finished gum base in combination with set of subsequent gum ingredients (SGIx) that does not yet form a finished set of subsequent gum ingredients (GBIx+SGIx).
- GPIx gum base ingredients
- SGIx subsequent gum ingredients
- Process 15-22 represent mixing processes where the effluent of mixer 1, such as mixer 102, 502 of mixing system 100, 500, respectively, is a set of gum base ingredients (GBIx) that is less than a finished gum base in combination with set of subsequent gum ingredients (SGIx) that does not yet form a finished set of subsequent gum ingredients (GBIx+SGIx).
- GGIx gum base ingredients
- SGIx+SGIx set of subsequent gum ingredients
- effluent GBIx+SGIx of mixer 1 is added to mixer 2 as an ingredient and added to another set of gum base ingredients, namely GBIy, to form a set of gum base ingredients GBIxy+SGIx, which is not yet a finished gum base or a finished set of subsequent gum ingredients.
- GBIy another set of gum base ingredients
- Another set of gum base ingredients GBIz could be added to form a gum structure that is either a finished gum base plus a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (FGB+SGIx) or a set of gum base ingredients that does not yet form a FGB in combination with a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (GBIxyz+SGIx).
- Another set of subsequent gum ingredients SGIy could be added to the effluent of mixer 2 to form a gum structure that is a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIxy+SGIxy) or a finished set of subsequent gum ingredients (GBIxy+FSGI).
- Another set of gum base ingredients GBIz and a set of subsequent gum ingredients could be added to effluent GBIxy+SGIx to form a gum structure that is either a finished gum base plus some subsequent gum ingredients that do not form a finished set of subsequent gum ingredients (FGB+SGIxy); a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients (GBIxyz+SGIxy); a set of gum base ingredients that is less than a finished gum base but includes a finished set of subsequent gum ingredients (GBIxyz+FSGI); or forms a finished gum product (FG) that includes both a finished gum base and a finished set of subsequent gum ingredients.
- GBIz and a set of subsequent gum ingredients SGIy
- Process 16 adds an additional set of gum base ingredients GBIy to effluent GBIx+SGIx of mixer 1.
- the additional set of gum base ingredients added to effluent GBIx+SGIx in mixer 2 is sufficient to form a finished gum base.
- the effluent of mixer 2 includes all of the gum base ingredients necessary for the contemplated gum structure, no more gum base ingredients will typically be added in downstream mixing.
- potential options for downstream mixing are limited to adding an additional set of subsequent gum ingredients SGIy.
- the set of subsequent gum ingredients SGIy may be sufficient to form a finished set of subsequent gum ingredients FSGI such that the effluent of downstream mixing is a finished gum composition (FG).
- the set of subsequent gum ingredients SGIy in combination with the previously added set of subsequent gum ingredients may be insufficient to form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum base in combination with some subsequent gum ingredients that is not yet a finished gum composition (FGB+SGIxy).
- effluent GBIx+SGIx of mixer 1 is added to mixer 2 as an ingredient and added to another set of subsequent gum ingredients, namely SGIy, to form a set of gum base ingredients GBIx+SGIxy, which is not yet a finished gum base or a finished set of subsequent gum ingredients.
- SGIy another set of subsequent gum ingredients
- Another set of gum base ingredients GBIy could be added to form a gum structure that is either a finished gum base plus a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (FGB+SGIxy) or a set of gum base ingredients that does not yet form a FGB in combination with a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (GBIxy+SGIxy).
- Another set of subsequent gum ingredients SGIz could be added to the effluent of mixer 2 to form a gum structure that is a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIx+SGIxyz) or a finished set of subsequent gum ingredients (GBIx+FSGI).
- GBIy and a set of subsequent gum ingredients could be added to effluent GBIx+SGIxy to form a gum structure that is either a finished gum base plus some subsequent gum ingredients that do not form a finished set of subsequent gum ingredients (FGB+SGIxyz); a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients (GBIxy+SGIxyz); a set of gum base ingredients that is less than a finished gum base but includes a finished set of subsequent gum ingredients (GBIxy+FSGI); or forms a finished gum product (FG) that includes both a finished gum base and a finished set of subsequent gum ingredients.
- FGB+SGIxyz a set of gum base ingredients and subsequent gum ingredients that is both less than a finished gum base and a finished set of subsequent gum ingredients
- GIxy+FSGI a finished set of subsequent gum ingredients
- Process 18 adds an additional set of subsequent gum ingredients SGIy to effluent GBIx+SGIx of mixer 1.
- the additional set of subsequent gum ingredients SGIy added to effluent GBIx+SGIx in mixer 2 is sufficient to form a finished set of subsequent gum ingredients.
- the effluent of mixer 2 includes all of the subsequent gum ingredients necessary for the contemplated gum structure, no more subsequent gum ingredients will typically be added in downstream mixing.
- potential options for downstream mixing in are limited to adding an additional set of gum base ingredients GBIy.
- the set of gum base ingredients GBIy may be sufficient to form a finished gum base such that the effluent of downstream mixing is a finished gum composition (FG).
- the set of gum base ingredients GBIy in combination with the previously added set of subsequent gum ingredients may be insufficient to form a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients in combination with some gum base ingredients that do not yet form a finished gum base (GBIxy+FSGI).
- Process 19 adds an additional set of gum base ingredients GBIy and an additional set of subsequent gum ingredients SGIy to effluent GBIx+SGIx of mixer 1 during mixing in mixer 2.
- the gum structure effluent GBIxy+SGIxy of mixer 2 is less than a FGB or a FSGI. Numerous downstream mixing options occur for effluent GBIxy+SGIxy of mixer 2.
- An additional set of gum base ingredients GBIz may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base (GBIxyz+SGIxy); or a finished gum base plus a set a subsequent gum ingredients that does not yet form a finished set of subsequent gum ingredients (FGB+SGIxy).
- an additional set of subsequent gum ingredients SGIz may be added to form a combination of gum base ingredients plus subsequent gum ingredients that does not yet form a finished gum base or a finished set of subsequent gum ingredients (GBIxy+SGIxyz); or a finished set of subsequent gum ingredients plus a set a gum base ingredients that does not yet form a finished gum base (GBIxy+FSGI).
- another set of gum base ingredients GBIz and another set of subsequent gum ingredients SGIz could be added to effluent GBIxy+SGIxy to form either a gum structure that is of a set of gum base ingredients and subsequent gum ingredients that is less than either a FGB or FSGI (GBIxyz+SGIxyz); a gum structure that includes a finished gum base plus a set of subsequent gum ingredients that is less than a FSGI (FGB+SGIxyz); a gum structure that is less than a gum base plus a finished set of subsequent gum ingredients (GBIxyz+FSGI); or a finished gum composition (FG).
- Process 20 adds an additional set of gum base ingredients GBIy and an additional set of subsequent gum ingredients SGIy to effluent GBIx+SGIx of mixer 1 during mixing in mixer 2.
- the additional set of gum base ingredients GBIy is sufficient to form a finished gum base.
- the effluent of mixer 2 is a finished gum base in combination with a set of subsequent gum ingredients that does not form a finished set of subsequent gum ingredients (FGB+SGIxy).
- the downstream mixing options for this example are the same as for Example 13.
- Process 21 adds an additional set of gum base ingredients GBIy and an additional set of subsequent gum ingredients SGIy to effluent GBIx+SGIx of mixer 1 during mixing in mixer 2.
- the additional set of subsequent gum ingredients SGIy is sufficient to form a finished set of subsequent gum ingredients.
- the effluent of mixer 2 is a set gum base ingredients that does not form a finished gum base in combination with a finished set of subsequent gum ingredients (GBIxy+FSGI).
- the downstream mixing options for this example are the same as for Process 6.
- Process 22 adds an additional set of gum base ingredients GBIy and an additional set of subsequent gum ingredients SGIy to effluent GBIx+SGIx of continuous mixer 502 during mixing in continuous mixer 504. It will be seen that only two mixers are needed for this example.
- the additional set of gum base ingredients GBIy and additional set of subsequent gum ingredients SGIy are sufficient to form, respectively, a finished gum base and a finished set of subsequent gum ingredients.
- the effluent of continuous mixer 504 is a finished gum composition (FG). No further gum base or subsequent gum ingredients are typically added to the effluent of continuous mixer 504 and thus only two mixers are required for this embodiment.
- the effluent of mixer 1 is a finished gum base.
- the effluent FGB of mixer 1 includes all of the gum base ingredients necessary for the contemplated gum structure, no more gum base ingredients will typically be added in subsequent downstream mixing.
- a first set of subsequent gum ingredients SGIx is added to effluent FGB of mixer 102 such that the effluent of mixer 104 is a finished gum base in combination with a set of subsequent gum ingredients that is not a finished set of subsequent gum ingredients (FGB+SGIx).
- the downstream mixing options are limited, again, to adding an additional set of subsequent gum ingredients SGIy.
- This additional set of subsequent gum ingredients may be sufficient to form a finished set of subsequent gum ingredients such that the effluent of mixer 2 is a finished gum composition (FG).
- the additional set of subsequent gum ingredients may not be sufficient to form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum base in combination with a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (FGB+SGIxy).
- the effluent of continuous mixer 502 is a finished gum base.
- the effluent FGB of continuous mixer 502 includes all of the gum base ingredients necessary for the contemplated finished gum base, no more gum base ingredients will typically be added in subsequent downstream mixing.
- a set of subsequent gum ingredients is added to the effluent of continuous mixer 502 that is a finished set of subsequent gum ingredients such that the effluent of continuous mixer 504 is a finished gum composition (FG).
- the effluent of mixer 1 is a finished gum base plus a set of subsequent gum ingredients SGIx that is less than a finished set of subsequent gum ingredients.
- the effluent of mixer 1 includes all of the gum base ingredients necessary for the contemplated gum structure, no more gum base ingredients will typically be added in subsequent downstream mixing.
- a second set of subsequent gum ingredients SGIy is added to effluent of mixer 102 such that the effluent of mixer 104 is a finished gum base in combination with a set of subsequent gum ingredients that is not a finished set of subsequent gum ingredients (FGB+SGIxy).
- the downstream mixing options are limited, again, to adding an additional set of subsequent gum ingredients SGIz.
- This additional set of subsequent gum ingredients may be sufficient to form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum composition (FG).
- the additional set of subsequent gum ingredients may not be sufficient to form a finished set of subsequent gum ingredients such that the effluent of downstream mixing is a finished gum base in combination with a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients (FGB+SGIxyz).
- the effluent of continuous mixer 502 is a finished gum base plus a set of subsequent gum ingredients SGIx that is less than a finished set of subsequent gum ingredients (FGB+SGIx).
- FGB+SGIx the effluent of continuous mixer 502 includes all of the gum base ingredients necessary for the contemplated finished gum base, no more gum base ingredients will typically be added in subsequent downstream mixing.
- a set of subsequent gum ingredients is added to the effluent of continuous mixer 502 that forms a finished set of subsequent gum ingredients with the previously added set of subsequent gum ingredients such that the effluent of continuous mixer 504 is a finished gum composition (FG) that does not require any additional downstream mixing.
- the effluent of mixer 1 is a finished set of subsequent gum ingredients.
- the effluent FSGI of mixer 1 includes all of the subsequent gum ingredients necessary for the contemplated gum structure, no more subsequent gum ingredients will typically be added in subsequent downstream mixing.
- a first set of gum base ingredients GBIx is added to effluent FSGI of mixer 102 such that the effluent of mixer 104 is a finished set of subsequent gum ingredients in combination with a set of gum base ingredients that does not form a finished gum base (GBIx+FSGI).
- the downstream mixing options are limited, again, to adding an additional set of gum base ingredients GBIy.
- This additional set of gum base ingredients GBIy may be sufficient to form a finished gum base such that the effluent of mixer 2 is a finished gum composition (FG).
- the additional set of gum base ingredients GBIy may not be sufficient to form a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients base in combination with a set of gum base ingredients that is less than a finished gum base (GBIxy+FSGI).
- the effluent of continuous mixer 502 is a finished set of subsequent gum ingredients.
- the effluent FSGI of continuous mixer 502 includes all of the subsequent gum ingredients necessary for the contemplated finished gum composition, no more subsequent gum ingredients will typically be added in subsequent downstream mixing.
- a set of gum base ingredients GBIx is added to the effluent of continuous mixer 502 that is a finished gum base such that the effluent of continuous mixer 504 is a finished gum composition (FG).
- the effluent of mixer 1 is a finished set of subsequent gum ingredients plus a set of gum base ingredients GBIx that is less than a finished gum base (GBIx+FSGI).
- GBIx+FSGI finished gum base
- the effluent of mixer 1 includes all of the subsequent gum ingredients necessary for the contemplated gum structure, no more subsequent gum ingredients will typically be added in subsequent downstream mixing.
- a second set of gum base ingredients GBIy is added to the effluent of mixer 102 such that the effluent of mixer 104 is a finished set of subsequent gum ingredients but still does not include a finished gum base (GBIxy+FSGI).
- the downstream mixing options are limited, again, to adding an additional set of gum base ingredients GBIz.
- This additional set of gum base ingredients may be sufficient to form a finished gum base such that the effluent of downstream mixing is a finished gum composition (FG).
- the additional set of gum base ingredients GBIz may not be sufficient to form a finished gum base such that the effluent of downstream mixing is a finished set of subsequent gum ingredients in combination with a set of gum base ingredients that is less than a finished set of subsequent gum ingredients (GBIxyz+FSGI).
- the effluent of continuous mixer 502 is a finished set of subsequent gum ingredients plus a set of gum base ingredients GBIx that is less than a finished gum base (GBIx+FSGI).
- GBIx+FSGI of continuous mixer 502 includes all of the subsequent gum ingredients necessary for the contemplated finished gum structure, no more subsequent gum ingredients will typically be added in subsequent downstream mixing.
- an additional set of gum base ingredients GBIy is added to the effluent of continuous mixer 502 that forms a finished gum base in combination with the previously added set of gum base ingredients such that the effluent of continuous mixer 504 is a finished gum composition (FG) that does not require any additional downstream mixing.
- a first contemplated example that will be described will focus on the formation of the finished gum structure of Example 7 of Table 3 using mixing system 300 of FIG. 3 and Process 16 of Table 4.
- mixer 1 takes the form of a continuous mixer 302 in the form of an extruder having a high shear section with high shear extruder elements suitable for dispersive mixing followed by a low shear section with lower shear elements suitable for distributive mixing.
- the high shear elements may be generally provided between feed ports 321 and 323 while the lower shear mixing elements may be provided between feed ports 324 and 326. While not illustrated, in this example, the high shear section and low shear section can be separated by a chiller portion, such as between feed port 323 and feed port 324.
- mixer 1 continuous mixer 302
- a first set of gum base ingredients GBIx are added.
- the finished gum base (FGB) of the desired finished gum (FG) is approximately 25% by weight of the FG.
- This set of gum base ingredients GBIx includes the following gum base ingredients.
- a high molecular weight elastomer in the form of butyl rubber is added at a rate of 5% by weight of the desired FGB along with a low molecular weight elastomer in the form of polyisobutylene at a rate of 10% by weight of the desired FGB to mixer 302 at feed port 321.
- a filler in the form of calcium carbonate is added at a rate of 10% by weight of the desired FGB at feed port 321.
- elastomer plasticizers in the form of rosin esters at the rate of 10% by weight of the desired FGB are added at feed port 323.
- GBIx is not yet a finished gum base (FGB) for the contemplated finished gum composition of Example 7.
- the mixture is to undergo a temperature drop in mixer 1 via a chiller proximate feed ports 323 and 324 to cool the mixture to a temperature of between about 160oF to 210 oF.
- a set of subsequent gum ingredients SGIx is added.
- the set of subsequent gum ingredients includes bulk sweeteners in the form of maltitol at a rate of 10% by weight of the C; xylitol at a rate of 10% by weight of the of the desired FG, and sorbitol at a rate of 30% by weight of the FG.
- the combination of gum base ingredients (GBIx) and subsequent gum ingredients (SGIx) is then expelled from continuous mixer 302.
- Effluent GBIx+SGIx of continuous mixer 302 is then added to one or more mixer 2s in the form of a lower shear batch mixer(s) 304 in the form of a kettle mixer.
- Effluent GBIx+SGIx is preferably added to batch mixer in a substantially liquid form with the kettle preheated to approximately 180-190 0 F.
- the additional gum base ingredients of GBIy include the following ingredients.
- An additional elastomer in the form of polyvinyl acetate at the rate of 25% by weight of the desired FGB is added.
- plasticizers/emulsif ⁇ ers in the form of lecithin, triacetin, and glycerol monosterate are added at a rate of 8% by weight of the desired FGB.
- waxes at a rate of 12% by weight and oils in the form of vegetable oils at the rate of 20% by weight of the desired FGB are added to mixer 2.
- Mixing of the ingredients in mixer 2 occurs for approximately 30 minutes. The final temperature should range from 160 0 F to 210 0 F.
- the gum structure effluent of batch mixer 304 (i.e. mixer 2) is a finished gum base (FGB) in combination with some subsequent gum ingredients (SGIx) but is not yet a finished gum composition as the effluent does not include all of the subsequent gum ingredients necessary for the contemplated finished gum composition of Example 7 of Table 3.
- the effluent of batch mixer 304 is a FGB+SGIx.
- an additional set of subsequent gum ingredients SGIy sufficient to form a finished set of gum ingredients are added in a third mixer to the effluent of batch mixer 304 to form a finished gum composition.
- the third mixer which performs downstream mixing in Table 4, is in the form of continuous mixer 306.
- Continuous mixer 306 is a low shear extruder.
- the set of subsequent gum ingredients SGIy includes the following ingredients. Sweeteners in the form of erythritol added at a rate of 10% by weight of the desired FG, hydrogenated starch hydro lysates at a rate of 5% by weightof the desired FG are added. Fluids in the form of glycerin are added at a rate of 3% by weight of the desired FG.
- the desired flavor is added at a rate of 1% by weight of the desired FG.
- Additional emulsifier such as in the form of lecithin is added at a rate of 1% by weight of the FG.
- high intensity flavors in the form of sucralose is added at a rate of 2% by weight of the FG.
- An amount of acid that complements the flavor is addedat a rate of 2.8% by weight of the FG.
- the desired color is added at a rate of 0.2% by weight of the FG.
- the subsequent gum ingredients of SGIy are added at low temperatures such as approximately 90 0 F to prevent degradation to the ingredients.
- mixer 1 takes the form of continuous mixer 502 in the form of an extruder having a high shear section with high shear extruder elements suitable for dispersive mixing followed by a low shear section with lower shear elements suitable for distributive mixing.
- the high shear elements may be generally provided between feed ports 521 and 523.
- the lower shear mixing elements may be provided between feed ports 524 and 526. While not illustrated, in this example, the high shear section and low shear section can be separated by a chiller portion, such as between feed port 523 and feed port 524.
- mixer 1 continuous mixer 502
- a set of gum base ingredients GBIx are added that are sufficient to form a finished gum base (FGB).
- the FGB of the desired FG for this example forms approximately 30% by weight of the FG.
- gum base ingredients of gum base Example 5 are added to mixer 1.
- These gum base ingredients include a high molecular weight elastomer in the form of butyl rubber added at a rate of 5% by weight of the desired FGB along with a low molecular weight elastomer in the form of polyisobutylene at a rate of 15% by weight of the desired FGB added to mixer 502 at feed port 521.
- a filler in the form of talc is added at a rate of 15% by weight of the desired FGB also added at feed port 521.
- Elastomer plasticizers in the form of rosin esters at the rate of 10% by weight of the desired FGB are added at feed port 523.
- gum base ingredients of GBIx are used to form a compounded elastomer gum structure and are thus subjected to the high shear mixing at a temperature of approximately 325°F.
- an additional elastomer in the form of polyvinyl acetate at the rate of 25% by weight of the desired FGB.
- plasticizers/emulsifiers in the form of lecithin, triacetin, and glycerol monosterate are added at a rate of 5% by weight of the desired FGB.
- Waxes at a rate of 5% by weight of the desired FGB and oils in the form of vegetable oils at the rate of 20% by weight of the desired FGB are added to mixer 1.
- mixer 1 employs a chiller to cool the mixture, with the temperature reduced, a set of subsequent gum ingredients SGIx is added to mixer 1.
- Subsequent gum ingredients which include bulk sweeteners in the form of maltitol at a rate of 30% by weight of the desired FG; xylitol at a rate of 10% by weight of the desired FG, and sorbitol at a rate of 30% by weight of the desired FG can be added to mixer 1 downstream of the chiller.
- the temperature of the mixture with the bulk sweeteners added is preferably held between 160 0 F and 200 0 F.
- the combination of the finished gum base (FGB) and subsequent gum ingredients (SGIx) is then expelled from continuous mixer 502 as a FGB+ SGIx.
- Effluent FGB+ SGIx of continuous mixer 502 is then added to mixer 2 in the form of a continuous mixer(s) 504 in the form of a low shear extruder, where more subsequent gum ingredients SGIy are added to complete the gum structure.
- SGIy is added to complete the gum structure.
- the set of subsequent gum ingredients SGIy includes the following ingredients.
- Sweeteners in the form of erythritol added at a rate of 5% by weight of the desired FG, hydrogenated starch hydro lysates at a rate of 3% by weight of the desired FG and isomalt added at a rate of 5% by weight of the desired FG are added.
- Fluids in the form of glycerin are added at a rate of 1% by weight of the desired FG.
- the desired flavor is added at a rate of 2% by weight of the desired FG.
- Additional emulsifier such as in the form of lecithin is added at a rate of 2% by weight of the desired FG.
- high intensity sweetners in the form of Ace-K is added at a rate of 1% by weight of the desired FG in addition to encapsulated sweetner in the form of apsartame encapsulated in PVA at a rate of 0.8% by weight of the desired FG.
- the desired color is added at a rate of 0.2% by weight of the desired FG.
- the subsequent gum ingredients of SGIy are mixed at low temperatures such as approximately 90 0 F to prevent degradation to the ingredients.
- the effluent of continuous mixer 504 includes both a finished gum base (FGB) and a finished set of subsequent gum ingredients (FSGI), which forms a finished gum structure (FG).
- a third contemplated example relates to kitting and, particularly, kitting where a significant portion of bulk ingredients are added at a remote location.
- mixing systems 100 of FIG. 1 and FIG. 13 Further, this example will use the gum structure of Example 6 of Table 3 and will employ a mixing process following Process 4 of Table 4 where the downstream mixing results in a finished gum composition (FG).
- FG finished gum composition
- the FGB of this FG forms approximately 30% by weight of the FG.
- mixer 1 will take the form of continuous mixer 102 that is a high shear high temperature extruder used to compound the elastomeric portion of the gum base ingredients GBIx of the finished gum composition.
- the set of gum base ingredients GBIx added to mixer 1 will include the following ingredients.
- a high molecular weight elastomer in the form of butyl rubber is added at a rate of 10% by weight of the desired FGB along with a low molecular weight elastomer in the form of polyisobutylene at a rate of 10% by weight of the desired FGB at feed port 121.
- a portion of the ultimate weight percent of the filler in the form of calcium carbonate is added at a rate of 10% by weight of the desired FGB at feed port 321 to assist in compounding the elastomer.
- the portion of filler added to mixer 1 is only a portion of the total weight percent of filler added to the gum structure as the rest of the filler will be added at the remote location 114.
- elastomer plasticizers in the form of rosin esters are added at a rate of 5% by weight of the desired FGB at feed port 123.
- These gum base ingredients of GBIx are used to form a compounded elastomer gum structure and are thus subjected to the high shear mixing at a temperature of approximately 325°F.
- the GBIx gum structure effluent of mixer 1 is not yet a finished gum base (it could be a master batch) for the contemplated finished gum composition of Example 6.
- the effluent GBIx is added to mixer 2 in the form of continuous mixer 104.
- Continuous mixer 104 is in the form of a low shear extruder.
- the partial gum base effluent GBIx is mixed with an additional set of gum base ingredients GBIy and a first set of subsequent gum ingredients SGIx.
- the set of gum base ingredients GBIy includes the following gum base ingredients.
- An additional elastomer in the form of polyvinyl acetate at the rate of 5% by weight of the desired FGB is added.
- plasticizers/emulsifiers in the form of lecithin, triacetin, and glycerol monosterate are added at a rate of 5% by weight of the desired FGB.
- waxes at a rate of 5% by weight of the desired FGB are added to the gum structure with mixer 2.
- a set of subsequent gum ingredients SGIx required for the finished gum composition of Example 6 of Table 3.
- the set of subsequent gum ingredients SGIx added to mixer 2 includes the lower weight percent gum ingredients except for formula specific ingredients such as flavors, acids and colors.
- the higher weight percent subsequent gum ingredients, such as bulk sweeteners, and the formula specific ingredients will be added at the remote location 114.
- fluids in the form of glycerin are added at a rate of 1% by weight of the desired FG.
- Additional emulsifier such as in the form of lecithin is added at a rate of 8% by weight of the desired FG.
- ingredients added to mixer 2 are added at a temperature between about 150-210 0 F.
- the effluent of mixer 2 includes gum base ingredients GBIxy that are less than a finished gum base and a set of subsequent gum ingredients that is less than a finished set of subsequent gum ingredients SGIx forming an effluent illustrated as GBIxy+ SGIx. Because this is an example of kitting, the effluent of mixer 2 will be passed to packaging system 116 for forming a storable gum structure in the forms of bricks or pellets. The storable gum structure effluent is then shipped using shipping system 118 to the second plant 114 where it is used as an ingredient by continuous mixer 106, which performs the downstream mixing of Table 4.
- the effluent GBIxy+SGIx of continuous mixer 104 is mixed with the rest of the ingredients to form a finished gum structure.
- the effluent GBIxy+SGIx is first melted by preheating to a temperature of approximately 65°C. Once the effluent GBIxy+SGIx is melted, it is added to continuous mixer 106, such as at feed port 161.
- an additional set of gum base ingredients GBIz and an additional set of subsequent gum ingredients SGIy is added to effluent GBIxy+SGIx with continuous mixer 106.
- This final set of gum base ingredients includes the rest of the calcium carbonate filler which is added to the mixture at a rate of 30% by weight of the desired FGB.
- the gum base ingredient of oil is also added in the form of vegetable oils at a rate of 20% by weight of the desired FGB.
- SGIy added to the mixture of continuous mixer 106 is the desired flavors added at a rate of 2.8% by weight of the desired FG, the desired acids at a rate of 1% by weight of the desired FG, and the colors added at a rate of 0.2% by weight of the desired FG.
- high intensity sweeteners in the form of sucralose, ace-K and aspartame are added at rates of 1% by weight of the desired FG, 1% by weight of the desired FG and 3% by weight of the desired FG, respectively.
- These additional subsequent gum ingredients finish the gum structure. It is desirable to add these ingredients at the remote location 114 as these ingredients can be very location specific and merely varying the flavors and colors can result in various different finished gums. Further, adding much of any of these ingredients can significantly effect the appearance and taste of a finished gum product.
- Table 5 provides a map of potential gum base ingredients that could be included in sets of gum base ingredients such as GBIxs, GBIys, and GBIzs used in the Process 1-30 of Table 4.
- Anti-oxidant is an optional ingredient that could be added to any one of these GBI options or could be a GBI ingredient itself.
- a set of gum base ingredients that could be an effluent or added to a mixer as an ingredient itself is variable and may include one or a plurality of gum base ingredients.
- a set of gum base ingredients GBI X , GB I y , and/or GBI Z used in the Processes 1-30 of Table 4, such as according to option 7 of Table 5, could comprise or consist of for example elastomer in the form of butyl rubber in combination with polyisobutylene; a filler in the form of calcium carbonate; waxes and oils in the form of vegetable oil.
- a set of gum base ingredients GBI X , GBI y , and/or GBI Z of the Processes 1-30 of Table 4, such as according to option 26 of Table 5, could comprise or consist of for example a plasticizer in the form of lecithin; a wax in the form of caranuba wax; and oils in the form of vegetable oil.
- the set of gum base ingredients does not include any elastomer ingredients, but is still a set of gum base ingredients.
- a single set of gum base ingredients includes more than one ingredient, not all of the ingredients need to be added at a single feed port or at the same time in a mixing cycle.
- a single ingredient added to an individual mixer could be added to a mixer at various locations or at varying times.
- an individual ingredient such as a filler can form a part of a first set of gum base ingredients GBIx added to a gum structure using a first mixer as well as part of a second set of gum base ingredients GBIy added to a gum structure using a second or third mixer.
- Table 6 provides a map of potential gum base ingredients that could be included in sets of gum base ingredients such as SGI x s, SGI y s, and SGI z s used in the Process 1-30 of Table 4.
- Sweeteners could be bulk sweeteners, high intensity sweeteners or the combination of bulk and high intensity sweeteners and could be in any suitable form [0394] From Table 6, it is clear that it is contemplated that a set of subsequent gum ingredients that could be an effluent or added to a mixer as an ingredient itself is variable and may include one or a plurality of subsequent gum ingredients.
- a set of subsequent gum ingredients SGI X , SGI y , and/or SGI Z used in the Processes 1-30 of Table 4, such as according to option 1 of Table 6, could comprise or consist of for example solely of sweeteners in the form of sorbitol, maltitol and maltitol.
- a set of subsequent gum ingredients SGI X , SGI y , and/or SGI Z used in the Processes 1-30 of Table 4, also according to option 1 of Table 6, could comprise or consist of for example bulk sweeteners in the form of sucrose and corn syrup.
- a set of subsequent gum ingredients SGI X , SGI y , and/or SGI Z used in the Processes 1-30 of Table 4, such as according to option 13 of Table 6, could comprise or consist of for example colors and flavors. This option could be beneficial when a master batch has previously been formed and the only remaining processing required it to give the gum structure its final appearance and ultimate flavor.
- a single set of subsequent gum ingredients includes more than one ingredient, not all of the ingredients need to be added at a single feed port or at the same time in a mixing cycle.
- a single subsequent gum ingredient added to an individual mixer could be added to a mixer at various locations or at varying times.
- an individual ingredient such as a sweetener can form a part of a first set of subsequent gum ingredients SGI X added to a gum structure using a first mixer as well as part of a second set of subsequent gum ingredients SGI y added to a gum structure using a second or third mixer.
- an individual ingredient such as a sweetener can include a combination of a plurality of individual specific ingredients such as for example sorbitol, erithritol, xylitol and maltitol all in combination.
- Table 7 provides a further conceptual map of ingredients that may be included in some potential combinations of sets of gum base ingredients (GBI x s, GBI y s, and/or GBI z s) in combination with potential sets of subsequent gum ingredients (SGI x s, SGI y s, and/or SGI z s) used in various ones of the Process 1-30 of Table 4.
- a GBI could be any GBI included in Table 5.
- Sweeteners could be bulk sweeteners, high intensity sweeteners or the combination of bulk and high intensity sweeteners.
- a set of subsequent gum ingredients GBIx, GBIy, and/or GBIz in combination with a set of subsequent gum ingredients SGIx, SGIy, and/or SGIz used in various ones of Processes 1-30 of Table 4, such as according to option 17 of Table 5 in combination with option 1 of Table 7, could comprise or consist of for example solely of filler in the form of calcium carbonate and bulk sweeteners in the form of sorbitol, maltitol and maltitol. This may be the case, such as in kitting where the last ingredients added to the gum structure are the large weight percent bulk ingredients.
- a set of subsequent gum ingredients GBIx, GBIy, and/or GBIz a set of subsequent gum ingredients SGIx, SGIy, and/or SGIz used in the Processes 1- 30 of Table 4, according to option 3 of Table 5 with option 1 of Table 7, could comprise or consist of for example consist of for example elastomer in the form of butyl rubber in combination with polyisobutylene; a filler in the form of calcium carbonate; and a plasticizer in the form of rosin esters as well bulk sweeteners in the form of sucrose and corn syrup.
- the gum base ingredients GBIx, GBIy, and/or GBIz would be added to provide a compounded elastomer portion of the gum structure, while the bulk sweetener would be added as a portion of the subsequent gum ingredients.
- Mixers used in the parallel mixing systems may be the same as those mixers described for the series mixing systems, and thus, may include both continuous mixers, batch mixers, and combinations thereof, as will be described in more detail below with particular examples of the parallel mixing systems.
- parallel mixing systems will refer to either: (a) mixing systems where an effluent of an upstream mixer is fed to two or more downstream mixers (simultaneously or sequentially) or (b) mixing systems where effluents of two or more upstream mixers are fed to a common downstream mixer (simultaneously or sequentially).
- mixers and series of mixers are considered to be “in parallel” with one another, when each of the mixers or series of mixers receives effluent from a common upstream mixer as an ingredient or a part of an ingredient, or each of the mixers or series of mixers feeds at least part of its effluent to a common downstream mixer.
- a parallel mixing system can be viewed as a plurality of series mixing systems in which one mixer in the parallel mixing system forms a part of two or more of the series mixing systems.
- contemplated mixers in series may include intermediate devices including temporary storage such as a surge tank or a forming device such as a pelletizer or brick molding system, an ingredient feeder, or another mixer such that an effluent of an upstream mixer is not directly fed into a downstream mixer arranged in series.
- the description of the parallel mixing systems will begin with a high-level overview of contemplated parallel mixing systems according to embodiments of the present invention as represented schematically by mixing systems 1400, 1500, 1600, 1700, 1800, 1900, 2000, 2100, 2200, 2300, 2400, 2500, and 2600 of FIGS. 14-26. As FIGS. 14-26 are schematic representations, they are intended for illustrative purposes and are not intended to limit the scope of the invention.
- the first contemplated parallel mixing system 1400 illustrated schematically in FIG. 14, includes mixer 1402 arranged in series and upstream of mixer 1404 and mixer 1406, which are arranged in parallel with each other. Parallel mixing system 1400 can be viewed as a combination of the series mixing systems, as described previously.
- each of the series can be viewed as individual series mixing systems such as any one of systems 500, 600, 1100 and 1200, described previously, and therefore can have all of the benefits and features of those systems.
- Mixer 1402 is independently in series with mixer 1404, effectively forming a first series, and mixer 1402 is also independently in series with mixer 1406, effectively forming a second series. While the schematic representation of mixing system 1400 illustrates only two downstream mixers 1404, 1406 arranged in parallel with each other, the invention is not so limited and a contemplated mixing system could include any number of downstream mixers arranged in parallel with mixers 1404 and 1406.
- an effluent of mixer 1402 may be fed to mixers 1404 and 1406 sequentially or simultaneously as an ingredient depending on the implementation.
- FIG. 14 shows mixer 1402 as directly feeding mixer 1404 and mixer 1406, intermediate devices such as surge tanks, forming devices, ingredient feeders or additional mixers may be incorporated between mixer 1402 and downstream mixers 1404, 1406 to hold and/or further process the effluent from mixer 1402 prior to being fed to mixers 1404, 1406.
- mixer 1402 may be a continuous mixer or a batch mixer.
- mixer 1404 and mixer 1406 may either be a continuous mixer or a batch mixer.
- mixer 1404 and mixer 1406, which are arranged in parallel with each other, may be a same type of mixer or different types of mixers. That is, in one implementation, both mixer 1404 and 1406 may be continuous mixers or batch mixers, or, in another implementation, mixer 1404 may be a continuous mixer while mixer 1406 is a batch mixer, or vice versa.
- mixer 1404 may be configured differently than mixer 1406.
- mixer 1404 and mixer 1406 may both be a continuous mixer, such as an extruder.
- extruder 1404 may be configured with high shear elements for dispersive mixing while extruder 1406 may be configured with low shear elements for distributive mixing.
- both mixers 1404 and 1406 may be the same type of mixers which are configured the same, but operated differently.
- both mixers 1404 and 1406 may be continuous mixers with high shear elements.
- mixers 1404, 1406 may be operated with different operating parameters, i.e. mixer 1404 running at a higher temperature and/or a higher screw speed than 1406.
- mixer 1404 and mixer 1406 may output the same effluent or different effluents.
- FIG. 14 illustrates each of mixers 1402 and 1404 with two ingredient feeders 1408, 1410 and 1412, 1414, respectively, and mixer 1406 without any ingredient feeders
- each of mixers 1402, 1404, 1406 may be provided with any number of ingredient feeders according to input ingredients.
- the ingredient feeders in parallel systems are similar to the ingredient feeders disclosed for series systems, i.e. gravity flow bins or hoppers, liquid holding tanks or canisters, ingredient impermeable sacs, carts, trays or other known applicable ingredient storage devices.
- the ingredient feeders may incorporate appropriate ingredient handling systems such as augers, conveyor belts, side feeders, gravity flow, vacuum conveying systems, liquid pumping, etc.
- the ingredient feeders may also incorporate optional blending devices, such as blenders or low shear mixers, to pre-blend ingredients from the ingredient feeders prior to feeding the ingredients to mixer.
- the ingredient feeders typically include metering devices such as load cells for monitoring the weight loss of a specific ingredient from a given ingredient supply. Alternatively, flow metering devices that measure volume per unit of time may also be used.
- a single ingredient feeder may feed an ingredient to multiple mixers.
- mixers 1402, 1404, 1406 may require a common ingredient.
- ingredient feeder 1408 containing that common ingredient can be configured to feed the ingredient to all three mixers sequentially.
- ingredient feeder 1408 may be configured to feed all three mixers 1402, 1404, 1406 simultaneously, such as a gravity flow system that is piped to all three mixers.
- an ingredient feeder may incorporate a conveyor system running between two batch mixers such that the conveyor belt is feeding its ingredient to a first batch mixer while a second batch mixer is running, and then the conveyor reverses its direction and feeds the second batch mixer while the first batch mixer is running.
- an effluent of mixer 1402 may be any number of gum structures, such as, by way of example, a premix, which is also referred to as a pre -blended mix, a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with subsequent gum ingredients, an elastomer with some other gum base ingredients and some subsequent gum ingredients, a gum base, or a gum base with subsequent gum ingredients.
- the effluent from mixer 1402 may be fed to mixer 1404 and mixer 1406 simultaneously or sequentially.
- one or more surge tanks may be incorporated to hold the effluent of mixer 1402 before it is further processed in mixers 1404, 1406.
- Each of the mixers 1404, 1406 receives the effluent from mixer 1402 as an ingredient and may process the effluent by itself or process the effluent with one or more gum base ingredients and/or one or more subsequent gum ingredients.
- Effluents of mixer 1404 and mixer 1406 may vary and may be a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with subsequent gum ingredients, an elastomer with some other gum base ingredients and some subsequent gum ingredients, a gum base, a gum base with subsequent gum ingredients, or a finished gum.
- a capacity and design of mixer 1402 is selected according to factors such as ingredients, effluent characteristics and throughput volume.
- mixer 1402 is typically a batch blender or a continuous mixer with a low shear elements for a low shear mixing.
- a desired effluent from mixer 1402 is a compounded elastomer which requires a high shear dispersive mixing of ingredients
- mixer 1402 is configured appropriately, such as a batch mixer with high shear mixing blades or an extruder with high shear dispersive mixing elements.
- mixer 1402 may be configured for varying shear mixings of ingredients to produce a desired effluent.
- effluents such as an elastomer with other gum base ingredients, an elastomer with subsequent gum ingredients, an elastomer with some other gum base ingredients and some subsequent gum ingredients, a gum base, or a gum base with subsequent gum ingredients may require a high shear mixing for masticating and compounding of an elastomer with compounding aids, and lower shear mixing for further mixing of other ingredients.
- the mixer parameters such as type of blades, angle of blades and/or speed of mixing, may be varied to achieve the differing shear mixing requirements.
- an extruder such as an extruder having various shear mixing elements may process ingredients of such effluents more effectively.
- an extruder can be configured to include several different elements constituting different shear sections of the extruder, i.e. an extruder including a section of high shear elements, a section of medium shear elements, and a section of low shear elements arranged in that order with the high shear section in the upstream.
- ingredients that require high shear mixing such as an elastomer and compounding aids, are added first to the high shear section, then ingredients that require a medium shear mixing are added to the medium shear section, and ingredients that require low shear mixing are then finally added to the downstream low shear section. Therefore, dispersive mixing, which typically requires high shear and distributive mixing which typically requires lower shear can be accomodated. These varying levels of shear also apply to temperature sensitivity of the various ingredients.
- mixer 1404 and mixer 1406 may be the same or different types of mixers, or configured the same or differently, or operated the same or differently according to ingredients to be processed in mixers 1404, 1406.
- mixer 1402 may be a batch mixer blending a premix consisting of elastomers and compounding aids.
- mixers 1404 and 1406 may produce the same effluent or different effluents. That is, mixers 1404 and 1406 may both be batch mixers, configured the same with the same blades, and operated the same using the same mixer parameters, i.e. the same temperature, same batch time, etc., to produce the same effluent, such as a compounded elastomer.
- mixers 1404 and 1406 may both be batch mixers which are configured the same but operated differently to produce different effluents.
- mixer 1404 and mixer 1406 may both be batch mixers configured with same blades.
- mixer 1404 may run its entire batch with one blade angle and one speed for high shear compounding of the premix to produce a compounded elastomer
- mixer 1406 may run its batch changing operating parameters during the batch run such that first part of batch run would compound the premix by high shear mixing and later part of the batch run would operate at lower shear for further mixing of additional ingredients with the compounded elastomer to produce an effluent which is more than a compounded elastomer such as a gum base or a finished gum.
- mixers 1404 and 1406 may both be batch mixers which are configured differently to produce different effluents.
- mixer 1404 may be configured with a single high shear blade and one ingredient feeder such that the ingredient feeder feeds the premix from mixer 1402 and processes the premix using the single high shear blade to output a compounded elastomer.
- mixer 1406 may be configured with two blades, one for high shear mixing and the other for low shear mixing, and multiple ingredient feeders. In mixer 1404, the premix may first be input and compounded with the high shear blade.
- other ingredient feeders may feed additional gum base ingredients or subsequent gum ingredients which are then processed with the compounded elastomer with the low shear blade to produce an effluent which is more than a compounded elastomer, i.e. any gum structure between a compounded elastomer with additional gum base ingredients to a finished gum.
- mixer 1402 may be a batch or a continuous mixer configured with high shear blades or elements to output a compounded elastomer in combination with a set of gum base ingredients but is less than a desired finished gum base, which is also referred to as a gum base master batch.
- mixer 1404 may be a continuous mixer such as an extruder
- mixer 1406 may be a batch mixer wherein the gum base master batch from mixer 1402 may be transported to a surge tank which holds and continuously feeds the gum base master batch to mixer 1404, while the gum base master batch for mixer 1406 may be transported to mixer 1406 just in time for a batch set up.
- mixer 1404 can process the gum base master batch with any combination of additional ingredients to produce an effluent such as a gum base with subsequent gum ingredients to a finished gum.
- mixer 1406, which is a batch mixer may be configured to process the gum base ingredients with additional ingredients to produce an effluent being more than a gum base master batch.
- mixers 1404 and 1406 may output the same effluent or output different effluents.
- one or more downstream mixers may be arranged in series with mixers 1404, 1406 for further gum making process to produce a desired finished gum.
- one or more mixers in system 1400 may be located in different parts of a plant or different plants in different locations.
- the above discussed implementations of system 1400 are just a few examples of numerous different possible implementations of system 1400, and the invention is not limited to these examples.
- the second contemplated parallel mixing system 1500 illustrated schematically in FIG. 15, includes a pair of mixers 1502, 1504, arranged in parallel with each other and upstream from a single downstream mixer 1506.
- Parallel mixing system 1500 can be viewed as a combination of the series mixing systems described previously. Again, each of the series can be viewed as individual series mixing systems such as any one of systems 500, 600, 1100 and 1200 described previously, and therefore can have all of the benefits and features of those systems.
- Mixer 1506 is independently in series with mixer 1502, effectively forming a first series, and mixer 1506 is independently in series with mixer 1504, effectively forming a second series.
- mixing system 1500 illustrates only a pair of upstream mixers 1502, 1504 arranged in parallel
- the invention is not so limited and a contemplated mixing system according to this arrangement can include any number of upstream mixers arranged in parallel with mixers 1502 and 1504.
- System 1500 is a reverse arrangement of system 1400, wherein mixers arranged in parallel, namely mixers 1502, 1504, are upstream to the single downstream mixer 1502 while mixers arranged in parallel in system 1400, namely mixers 1404, 1406, are downstream from single upstream mixer 1402.
- mixers of system 1500 may be either a batch mixer or a continuous mixer depending on ingredients to be processed and a desired throughput from each mixer.
- FIG. 15 illustrates mixer 1502 with ingredient feeders 1508, 1510, mixer 1506 with ingredient feeders 1512, 1514, and mixer 1504 without any ingredient feeders.
- each mixer may be provided with any number of ingredient feeders depending on ingredients to be processed in each mixer.
- the details of ingredient feeders and their features in system 1500 are the same as the ingredient feeders described in system 1400.
- Effluents of upstream mixers 1502 and 1504, which are arranged in parallel with each other, may be, by way of example, a premix, a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with gum ingredients, an elastomer with some other gum base ingredients and some gum ingredients, a gum base, or a gum base with other gum ingredients.
- Mixer 1502 and mixer 1504 may produce the same or different effluents.
- Mixers 1502 and 1504 may output effluents simultaneously or sequentially.
- Downstream mixer 1506 can receive the effluents from mixer 1502 and mixer 1504 sequentially or simultaneously as ingredients to produce an effluent such as a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with gum ingredients, an elastomer with some other gum base ingredients and some gum ingredients, a gum base, a gum base with other gum ingredients, or a gum.
- an effluent such as a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with gum ingredients, an elastomer with some other gum base ingredients and some gum ingredients, a gum base, a gum base with other gum ingredients, or a gum.
- the effluents of mixers 1502, 1504 are both used as an ingredient of a single effluent of mixer 1506.
- the effluents of mixers 1502, 1504 may be combined in mixer 1506 to form a single effluent.
- the two separate effluents can be used to form sequentially separate effluents.
- a capacity and design of each mixer is selected according to factors such as ingredients, effluent formulations and throughput volume.
- mixers arranged in parallel with each other in system 1500 namely mixer 1502 and mixer 1504, may be the same or different types of mixers, the same type of mixers configured differently, or the same type of mixers configured the same but operated differently.
- mixer 1502 and mixer 1504 may both be batch mixers which are configured the same and operated with the same process parameters to produce the same effluent such as, for example, a gum base.
- Mixer 1502 and mixer 1504 may supply the gum base to mixer 1506, sequentially or simultaneously.
- a batch schedule of mixers 1502, 1504 is preferably set up such that mixers 1502, 1504 feed mixer 1506 sequentially to provide a more continuous supply of the gum base to mixer 1506.
- mixer 1502 and mixer 1504 may both be continuous mixers, such as extruders which are configured the same with the same screw arrangements for both dispersive and distributive mixings.
- extruders 1502 and 1504 may be operated with different process parameters such as different barrel temperatures and/or screw rotating speeds to process two different sets of gum base ingredients to produce two different gum bases which are received by mixer 1506 simultaneously as ingredients to produce yet a different third gum base or other gum structures which are more than a gum base, such as a finished gum master batch.
- mixer 1506 is selected such that its capacity is much larger than, or at least as large as, the capacity of mixers 1502 and 1504 combined, to maximize utilization of mixers 1502, 1504, and 1506.
- mixer 1502 and mixer 1504 may feed mixer 1506 sequentially such that the gum base from mixer 1502 is first received by mixer 1506 to process the gum base with a first set of subsequent gum ingredients to produce a finished gum requiring such a gum base.
- the gum base feed from mixer 1502 would stop and the different gum base from mixer 1504 feeds mixer 1506 wherein the gum base is processed with a second set of subsequent gum ingredients to produce a different finished gum.
- the capacity of mixer 1506 is preferably larger than the capacity of mixers 1502 or 1504 because, typically, a finished gum includes less than 50% by weight of a gum base.
- mixer 1502 may be a continuous mixer and mixer 1504 is a batch mixer.
- mixer 1502 may be configured with elements for various shear mixings to produce a gum base with subsequent gum ingredients.
- batch mixer 1504 may also be configured such that it produces the same gum structure or different gum structure than the effluent of mixer 1502. Again, mixer 1502 and mixer 1504 may run simultaneously or sequentially.
- the above discussed implementations of system 1500 are just a few examples of numerous different possible implementations of system 1500, and the invention is not limited to these examples.
- the third contemplated parallel mixing system 1600 builds upon and combines parallel mixing system 1400 and parallel mixing system 1500.
- Parallel mixing system 1600 includes a pair of mixers 1602, 1604 arranged in parallel with each other and upstream from another pair of mixers 1606, 1608 arranged in parallel with each other.
- Mixer 1602 is arranged in series, individually, with both downstream mixers 1606, 1608.
- mixer 1604 is arranged in series, individually, with both downstream mixers 1606, 1608.
- upstream mixers 1602 and 1604 which are arranged in parallel, are configured to feed downstream mixers 1606 and 1608, which are arranged in parallel, wherein each of upstream mixers are configured to feed both downstream mixers.
- each mixer in this system may be either a batch mixer or a continuous mixer. Further, more than two mixers may be included in each parallel arrangement.
- FIG. 16 illustrates mixer 1602 with ingredient feeders 1610, 1612, mixer 1606 with ingredient feeders 1614, 1616, and mixers 1604 and 1606 without any ingredient feeders.
- a mixer can be provided with any number of ingredient feeders. The description of ingredient feeders remains the same as the other series and parallel mixing systems.
- Effluents of upstream mixers 1602 and 1604 may be a premix, a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with gum ingredients, an elastomer with some other gum base ingredients and some gum ingredients, a gum base, or a gum base with other gum ingredients.
- Mixers 1602 and 1604 may produce the same effluent or different effluents.
- Effluents of downstream mixers 1606, 1608 may be a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with gum ingredients, an elastomer with some other gum base ingredients and some gum ingredients, a gum base, a gum base with other gum ingredients, or a gum. Again, mixer 1606 and mixer 1608 may produce the same effluent or different effluents.
- mixers arranged in parallel i.e. mixers 1602, 1604 and mixers 1606, 1608, may be the same or different types of mixers, the same type of mixers configured differently, or the same type of mixers which are configured the same but operated differently to produce the same or different effluents.
- the mixers arranged in parallel may produce effluents simultaneously or sequentially.
- downstream mixers may utilize upstream effluents simultaneously or sequentially.
- mixer 1602 and mixer 1604 may be outputting effluents simultaneously, wherein mixer 1602 feeds mixer 1606 while mixer 1604 feeds mixer 1608 for a period of time, and switch off such that mixer 1602 feeds mixer 1608 while mixer 1604 feeds mixer 1606 for a subsequent period of time.
- mixer 1602 and mixer 1604 may simultaneously feed mixer 1606 for a period of time then simultaneously feed mixer 1608 for a subsequent period of time.
- mixer 1602 and mixer 1604 may produce effluents sequentially, wherein mixer 1602 feeds both mixer 1606 and mixer 1608, simultaneously or sequentially, then the feed from mixer 1602 stops and mixer 1604 feeds both mixer 1606 and mixer 1608, simultaneously or sequentially.
- effluent of mixer 1606 may be fed to mixer 1608, and effluent of mixer 1608 may be fed to mixer 1606.
- ingredients are added to a mixer such that more viscous ingredients are added first.
- viscous ingredients such as elastomers are added to upstream feed ports.
- viscous ingredients are added to a mixer during a batch set up, rather than being added later during a batch run.
- viscous ingredients are added in the most upstream mixers and are not typically, but not always, added to downstream mixers. Therefore, implementations of mixing systems 1400, 1500, 1600 may also be limited such that downstream mixers are not typically processing more viscous ingredients than upstream mixers.
- mixing systems 1400, 1500 and 1600 are illustrated schematically in FIGS. 17-26 wherein an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged, at least in part, in parallel with that mixer or an effluent from a mixer may be direct to a downstream mixer of a mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- Mixing systems 1700 and 1800 are configured similar to system 1400, wherein one upstream mixer is arranged in series with two downstream mixers arranged in parallel with each other.
- System 1700 illustrated schematically in FIG. 17, includes mixer 1702 arranged in series and upstream of mixer 1704 and mixer 1706, which are arranged in parallel with each other.
- an effluent of mixer 1702 may be directed to mixers 1704 and 1706 sequentially or simultaneously.
- System 1700 is configured such that an effluent of mixer 1704 may be further processed by recirculting the effluent back through mixer 1704.
- an effluent for mixer 1706 may be further processed by recirculating the effluent back to mixer 1702, such that the effluent is reprocessed by mixer 1702 and then either reprocessed by mixer 1706 or processed by mixer 1704.
- mixer 1702 may be a continuous mixer or a batch mixer.
- mixer 1704 and mixer 1706 may either be a continuous mixer or a batch mixer.
- mixer 1704 and mixer 1706 which are arranged in parallel with each other, may be a same type of mixer or different types of mixers. That is, in one implementation, both mixer 1704 and 1706 may be continuous mixers or batch mixers. In another implementation, mixer 1704 may be a continuous mixer while mixer 1706 is a batch mixer, or vice versa.
- mixer 1704 may be configured differently than mixer 1706.
- mixer 1704 and mixer 1706 may both be a continuous mixer, such as an extruder.
- extruder 1704 may be configured with high shear elements for dispersive mixing while extruder 1706 may be configured with low shear elements for distributive mixing.
- both mixers 1704 and 1706 may be the same type of mixers which are configured the same, but operated differently.
- both mixers 1704 and 1706 may be continuous mixers with high shear elements.
- mixers 1704, 1706 may be operated with different operating parameters, i.e. mixer 1704 running at a higher temperature and/or a higher screw speed than 1706.
- an effluent of mixer 1704 may require a longer mixing time.
- the effluent of mixer 1704 may be recirculated as an ingredient of mixer 1704.
- an effluent of mixer 1706 may also require further processing.
- the effluent of mixer 1706 may be recirculated through system 1700 by feeding the effluent of mixer 1706 back to mixer 1702 as an ingredient and reprocessing through mixers 1702, 1704 and 1706.
- each mixer may or may not add additional ingredients to the effluent.
- System 1800 illustrated schematically in FIG. 18, includes mixer 1802 arranged in series and upstream of mixer 1804 and mixer 1806, which are arranged in parallel with each other.
- an effluent of mixer 1802 may be fed to mixers 1804 and 1806 sequentially or simultaneously, wherein a portion of an effluent of mixer 1804 or its entirety may optionally be directed to mixer 1806 for further processing.
- Mixers 1804 and 1806 can be viewed as being simultaneously configured, as being in series, and as being in parallel with one another.
- Mixing systems 1900, 2000, 2100, and 2200 are configured similar to system 1400 but include additional downstream mixers.
- Mixing system 1900 illustrated schematically in FIG. 19, includes mixer 1902 arranged in series and upstream of mixer 1904 and mixer 1906, which are arranged in parallel with each other. Further, mixing system 1900 includes mixer 1908 in series and downstream of mixer 1904 and mixer 1910 in series and downstream of mixer 1906.
- an effluent of mixer 1902 may be fed to mixers 1904 and 1906 sequentially or simultaneously with effluents of mixers 1904 and 1906 feeding their downstream mixers 1908 and 1910. Further, in system 1900, an effluent of mixer 1904 may be directed to mixer 1910 which is a downstream mixer of mixer 1906 which is arranged in parallel with mixer 1904.
- a portion of the effluent of mixer 1904 may be directed to mixer 1908 with the remaining effluent of 1904 feeding mixer 1910.
- the effluent of mixer 1904 may feed mixer 1908 and mixer 1910 alternatively. That is, the entire effluent of mixer 1904 may first feed mixer 1908 for a set period of time, then the entire effluent of mixer 1904 may feed mixer 1910 for a subsequent period of time. Further, the amounts of effluent that are fed to mixers 1908 and 1910 may be the same or different. Further, the effluent that is fed to mixer 1908 may be different than an effluent fed to mixer 1910, particularly when the mixers 1908 and 1910 are fed at subsequent periods.
- Mixing system 2000 illustrated schematically in FIG. 20, is configured similarly to mixing system 1900.
- Mixing system 2000 is presented to illustrate that mixing systems with similar configurations may produce different outputs with ingredient feeders adding different ingredients to different mixers in the mixing system.
- all ingredients processed through system 1900 are added to mixer 1902 such that no additional ingredient is added to downstream mixers, thus producing outputs from mixer 1908 and mixer 1910 that have the same ingredient composition.
- the downstream mixers are configured the same, the output of these mixers will be the same. However, if they are configured differently, different outputs may be produced.
- additional ingredients may be added to downstream mixers as shown in mixing system 2000.
- a set of gum base ingredients may be added and processed in mixer 2002 to produce a finished gum base.
- the finished gum base from mixer 2002 can feed mixers 2004 and 2006 simultaneously or sequentially as an additional ingredient.
- mixer 2004, a set of subsequent gum ingredients may be added and mixed with the gum base from mixer 2002 to output a gum base with a set of subsequent gum ingredients, which is less than a finished gum.
- a portion of the effluent of mixer 2004 may be further processed in mixer 2008 without additional ingredients to output an effluent less than a finished gum which is ready for further downstream process.
- the remaining portion of the mixer 2004 effluent may be directed to mixer 2010 and mixed with an additional set of subsequent gum ingredients to output a finished gum.
- mixer 2006 can also receive the effluent from mixer 2002, wherein a set of subsequent gum ingredients, which is different than the set of subsequent gum ingredients added to mixer 2004, is added to produce a gum base with a set of subsequent gum ingredients, which is different than the effluent of mixer 2004 and less than a finished gum.
- the effluent of 2006 and effluent of 2004 may be fed to mixer 2010 simultaneously or sequentially.
- mixer 2010 may receive the effluent of mixer 2004 and the effluent of mixer 2006 simultaneously and process the effluents with an additional set of subsequent gum ingredients to produce a first finished gum formulation.
- mixer 2010 may first receive the effluent of mixer 2004 for a set period of time and mixes the effluent with an additional set of subsequent gum ingredients to output a second finished gum formulation. Then, mixer 2010 can receive the effluent from mixer 2006 for a subsequent period of time and mixes the effluent with an additional set of subsequent gum ingredients to produce a third finished gum formulation. Numerous other outputs can be contemplated using such mixing system with ingredient feeders adding different ingredients to different mixers in the system.
- Mixing systems 2100 and 2200 are configured similarly to mixing systems 1900 and 2000, but include recirculation of some effluents.
- mixer 2102 may feed its effluent to mixer 2104 and mixer 2106 simultaneously or sequentially.
- Mixer 2104 may process the effluent of mixer 2102 together with additional ingredients.
- Mixer 2108 which is arranged in series and downstream of mixer 2104 can receive an effluent of mixer 2104 and further process the effluent for an additional mixing time.
- An effluent of mixer 2108 may then be recirculated by feeding the effluent back to mixer 2104 as an ingredient.
- Mixer 2104 may or may not add additional ingredients with the effluent of mixer 2108. The new effluent of mixer 2104 is again fed to mixer 2108 for further processing.
- mixer 2106 may process the effluent of mixer 2102 together with additional ingredients.
- An effluent of mixer 2106 is fed to mixer 2110 for further mixing.
- An effluent of mixer 2110 can be processed for an additional mixing time by recirculating the effluent back into mixer 2110 as an ingredient, as shown in FIG. 21.
- Such recirculation of the effluent can increase mixing time of the ingredients or may produce various gum formulations by adding different ingredients to mixers at different times.
- mixer 2202 of mixing system 2200 can feed its effluent to mixer 2204 and 2206 simultaneously or sequentially.
- Mixer 2204 may process the effluent of mixer 2202 with additional ingredients.
- Mixer 2208 which is arranged in series and downstream of mixer 2204, can mix an effluent of mixer 2204 for an additional period of time.
- An effluent of mixer 2208 is then recirculated through mixer 2204 as an ingredient, wherein the effluent is processed together with additional ingredients.
- a new effluent of mixer 2204 may be mixed further in mixer 2208.
- mixer 2206 can receive the effluent of mixer 2202 and process the effluent with additional ingredients.
- An effluent of mixer 2206 is further processed with additional ingredients in mixer 2210 which is arranged in series and downstream of mixer 2206.
- An effluent of mixer 2210 may be further processed by recirculation, wherein the effluent is fed back to mixer 2206 as an ingredient with other additional ingredients.
- An effluent of mixer 2206 may be further processed in mixer 2210 with additional ingredients to produce a new effluent, which is different than the effluent of mixer 2210, prior to the recirculation.
- an effluent of mixer 2204 can be processed for an additional mixing time by recirculating the effluent back into mixer 2204 as an ingredient.
- effluents of mixers 2206, 2208 and 2210 may be recirculated for additional mixing time.
- Mixing systems 2300, 2400, 2500 and 2600 are configured similarly to system 1500, wherein two upstream mixers are arranged in parallel with each other and in series with one downstream mixer.
- System 2300 illustrated schematically in FIG. 23, includes mixer 2302 arranged in parallel with mixer 2304, which are arranged in series and upstream of mixer 2306.
- an effluent of mixer 2302 and an effluent of mixer 2304 may feed mixer 2306 sequentially or simultaneously, wherein an effluent of mixer 2306 may be further processed by recirculating the effluent back to mixer 2302.
- a new effluent of mixer 2302 may be further processed in mixer 2306 with additional ingredients and/or the effluent of mixer 2304 to output a new effluent, which is different than the effluent of mixer 2306 prior to the recirculation.
- mixer 2402 and mixer 2404 of mixing system 2400 can feed mixer 2406 simultaneously or sequentially.
- mixer 2404 also feeds mixer 2402, which is arranged in parallel with mixer 2404.
- mixer 2404 may feed a portion of its effluent to mixer 2406 simultaneously with remaining portions of the effluent feeding mixer 2402.
- mixer 2404 may feed mixer 2406 and mixer 2402 sequentially.
- Mixing system 2500 illustrated schematically in FIG. 25, also includes two mixers 2502 and 2504 arranged in parallel with each other, wherein mixers 2502 and 2504 may feed mixer 2506 simultaneously or sequentially, which is arranged in series and downstream of mixers 2502 and 2504.
- mixer 2502 may process a set of ingredients to produce a compounded elastomer.
- the compounded elastomer is further processed by recirculating the compounded elastomer back through mixer 2502 as an ingredient, wherein a set of gum base ingredients are mixed with the compounded elastomer during the recirculation path through mixer 2502 to produce a first finished gum base formulation.
- mixer 2504 may process a set of gum base ingredients to output a second finished gum base formulation which is different than the first finished gum base formulation.
- mixer 2502 and mixer 2504 may feed mixer 2506 simultaneously or sequentially. Where effluents of mixer 2502 and 2504 are fed sequentially, mixer 2506 may first receive the first finished gum base from mixer 2502 and process the first finished gum base with a set of subsequent gum ingredients to output a first finished gum formulation. Then, mixer 2506 may receive the second finished gum base from mixer 2504 and process the second finished gum base with a set of subsequent gum ingredients to output a second finished gum formulation.
- mixer 2506 may receive the first finished gum base and the second finished gum base from mixers 2502 and 2504 simultaneously and mix them with a set of subsequent gum ingredients to output a third finished gum formulation which is different than the first finished gum and the second finished gum formulations. Numerous other effluents may be produced using such mixing system with the recirculation features.
- mixing system 2600 which is illustrated schematically in FIG. 26, two upstream mixers 2602 and 2604, which are arranged in parallel with each other, may each process a same set of ingredients or different sets of ingredients.
- two upstream mixers 2602 and 2604 may feed the downstream mixer 2606 simultaneously or sequentially.
- mixer 2606 may process an effluent of mixer 2602 with additional ingredients or may process an effluent of mixer 2604 with additional ingredients, or may process the effluent of mixer 2602 together with the effluent of mixer 2604 and additional ingredients.
- An effluent of mixer 2606 may then be further processed by recirculating the effluent back through mixer 2606 as an ingredient, wherein additional ingredients may or may not be added during the recirculation path.
- mixing systems 1400, 1500, 1600 and their variation systems 1700-2600 can have numerous structural and operational arrangements that provide numerous benefits and features in addition to those features identified previously for the series systems described above.
- a parallel system may be combined in parallel with another parallel system.
- a first parallel system may be combined in series with a second parallel system.
- a parallel system may be combined upstream or downstream with a series system.
- these mixing systems 1400, 1500, 1600 may be part of larger mixing systems that include more or less upstream or downstream mixers and more or less parallel mixers.
- a first benefit and advantage of implementing some embodiments of parallel mixing systems having multiple downstream mixers arranged in parallel with each other, such as mixing systems 1400, 1600, is that such embodiments enable the mixing system to be simultaneously configured to produce and output multiple different gum structures. While being simultaneously configured to produce multiple gum structures, the multiple gum structures may be formed simultaneously or sequentially.
- the effluent of mixer 1402 may be a common gum base used in two separate finished gums.
- the common gum base effluent of mixer 1402 can be fed to parallel downstream mixers 1404, 1406.
- Mixer 1404 can then process the common gum base with a selected set of subsequent gum ingredients for a first finished gum, while mixer 1406 processes the gum base with a different set of subsequent gum ingredients for a second finished gum, for example, a different flavored gum or different colored gum.
- such an implementation also may improve productivity by maximizing utilization of each mixer in the mixing system. That is, because a gum base typically makes up less than 50% by weight of a finished gum, providing multiple mixers arranged in parallel and downstream of an upstream mixer producing a common gum base may enable the upstream mixer to run at its full capacity by providing multiple downstream mixers which can receive and process the gum base from the upstream mixer.
- a mixing system such as mixing system 1400 may be a gum base mixing system for producing finished gum bases or be a part of a larger mixing system that forms finished gum.
- mixing system 1400 could be used to simultaneously form two different gum bases having different formulations.
- Mixer 1402 may be used to compound an elastomer component to form a gum structure that is less than a finished gum base, but that is common to both gum bases. This common elastomer component is then fed to both mixers 1404 and 1406, sequentially or simultaneously, where different sets of gum base ingredients or different ratios of gum base ingredients are added to the common compounded elastomer component to produce two different finished gum bases.
- mixers 1404, 1406 can produce two different gum structure types.
- mixer 1404 may produce a gum base master batch which is less than a gum base, while mixer 1406 produces a gum base with at least one subsequent gum ingredient.
- Mixer 1404 and mixer 1406 could output effluents simultaneously or sequentially.
- Another benefit and advantage of implementing some embodiments of parallel gum mixing systems 1400, 1500 and 1600 is that mixing systems 1400, 1500, 1600 have built in redundancy.
- the redundancy of the parallel mixers can reduce or eliminate downtime of the entire mixing system, such as for batch set-up, mixer reconfiguration, repair or cleaning.
- the mixers that are arranged in parallel are preferably similar such that the parallel mixer that takes over for the non-operating mixer can easily be used to replace the output of the non-operating mixer.
- the parallel mixers need not be similar.
- Mixers arranged in parallel with each other may be the same or different types of mixers, or the same type of mixers configured differently with different number and/or types of ingredient feeders, different shear blades or elements, etc.
- mixers in parallel may be the same type of mixers which are configured the same, but operated differently with different sets of process parameters such as different mixer temperatures, different mixer speeds, etc.
- upstream parallel mixers 1602, 1604 of gum mixing system 1600 produce a same gum structure which feeds both downstream mixers 1606, 1608, which are running separate gum formulations, and mixer 1602 needs to be repaired, production of neither gum formulations need be completely stopped due to the failure of mixer 1602.
- Upstream mixer 1604 can be used to feed both mixers 1606 and 1608 until mixer 1602 is repaired and back online. While output of mixers 1606, 1608 may be limited because less initial upstream production may be available, the redundancy provides a significant benefit because both gum formulations can be generated, albeit at a potentially reduced rate. Without the redundancy, i.e. if mixers 1602 and 1606 were a separate independent series mixing system from mixers 1604 and 1608, one of the gum formulations may not be able to be formed until mixer 1602 was repaired.
- mixer 1604 can run at a higher throughput rate while mixer 1602 is down to compensate for the output from mixer 1602. Because downstream mixers in gum mixing systems are typically required to process a larger volume of ingredients than upstream mixers, the upstream mixers, such as mixers 1602, 1604, may not be running at their full capacity, limited by capacities of downstream mixers 1606, 1608. For example, where mixers 1602, 1604, 1606, 1608 are similar in capacity, upstream mixers 1602, 1604 may not be running at their full capacity in producing a gum base, while downstream mixers 1606, 1608 are running at their full capacity to produce finished gums utilizing the gum base from mixers 1606, 1608 as an ingredient.
- a gum base typically makes up less than 50% by weight of a finished gum, requiring the downstream mixers to process more than twice the amount of ingredients compared to the upstream mixers.
- a downtime of one of the upstream mixers may be fully compensated by running the other upstream mixer at its full capacity, allowing the downstream mixers to maintain their full capacity operations.
- parallel gum mixing systems 1400, 1500, 1600 can improve overall flexibility of a mixing system and increase utilization of the mixing system.
- the upstream mixer 1402 can be configured to sequentially produce two different gum structures for sequential feeding of mixers 1404 and 1406.
- mixer 1404 can process a first set of gum base ingredients to produce a first gum structure to feed batch mixer 1404 wherein the first gum structure is combined with additional ingredients to produce a first finished gum base. Then, while batch mixer 1404 is running its batch, mixer 1402 can process a second set of gum base ingredients to produce a second gum structure to feed batch mixer 1406 wherein the second gum structure is combined with additional ingredients to produce a second finished gum base.
- the second set of gum base ingredients may include different individual ingredients or the same individual ingredients in different ratios than the first set of gum base ingredients, and the second set of gum base ingredients is comparable with the first set of gum base ingredients such that cleaning of mixer 1402 between processing of the first and second sets of gum base ingredients is not required or minimized.
- the sequential production of two gum structures by the upstream mixer 1402 improves the utilization of the mixing system since it allows running mixer 1402 at a larger capacity to supply two downstream mixers 1404, 1406, instead of supplying one downstream mixer 1404, while allowing two downstream mixers 1404, 1406 to run without a downtime waiting for an upstream supply. It also improves flexibility by enabling production of two different finished gum formulations using a single mixing system.
- a further benefit and feature of implementing parallel gum mixing systems 1400, 1500, 1600 is that contamination can be reduced by dedicating different ones of the parallel mixers to specific differing sets of ingredients, i.e. sets that have at least one ingredient that is not in common.
- first set of gum structures that use a talc-based filler and a second set of gum structures that uses a calcium carbonate-based filler.
- the parallel mixing systems such as mixing system 1400
- the first set of gum structures using the talc-based filler can be dedicated to being run through mixer 1404 with all of the talc being added in mixer 1404
- the second set of gum structures using calcium carbonate can be dedicated to being run through mixer 1406 with all of the calcium carbonate being added in mixer 1406.
- the talc and calcium carbonate will never be run in the same mixer of mixing system 1400, thereby eliminating any risk of contamination.
- a further benefit and feature of implementing parallel gum mixing systems 1400, 1500, 1600 is that the parallel mixing systems 1400, 1500, 1600 can be used to optimize the mixing process based on numerous characteristics, such as the preferred mixing process for a given gum structure or maximization of the throughput of processed material.
- a first type of mixer i.e. a batch mixer
- the second type of mixer i.e. the continuous mixer
- the mixing systems 1400, 1500, 1600 improve the mixing process by allowing selection of a mixer in the parallel system according to characteristics of each gum structure to optimize processing of each gum structure.
- implementing parallel gum mixing systems can be used to maximize final gum process line output by optimizing process throughput.
- the downstream mixer is preferably coordinated to the throughput capacity of the upstream mixer to optimize utilization and/or efficiency of the line. That is, when the upstream mixer has a larger process capacity than can be handled by the downstream mixer, the lower capacity downstream mixer can create a backlog of the upstream mixer effluent or require the upstream mixer to be run at less than full capacity.
- the excess of the upstream mixer effluent has to be held in a surge tank, and in the event that the surge tank capacity runs out, the upstream mixer will have to be stopped until the downstream mixer can catch up, or the upstream mixer must be run at less than full capacity.
- a parallel mixing system such as parallel gum mixing system 1400, can alleviate this process inefficiency by adding additional downstream mixers 1406 to utilize the excess capacity provided by the upstream mixer 1402, such that the upstream mixer 1402 can run at full capacity.
- An additional benefit of implementing parallel gum mixing systems 1400, 1500, 1600 is that kitting of gum structures can be performed in varying manners.
- a masterbatch (either gum base masterbatch or finished gum masterbatch) may be formed at a first location in large quantity using a large capacity mixer 1402.
- This masterbatch can then be shipped to numerous other remote locations for finalizing the gum product, thereby incorporating the benefits of kitting described previously.
- This may be particularly beneficial in the event that a new highly efficient large production upstream mixer 1402 is implemented, but the numerous downstream lines at varying remote locations with more limited throughput capacity can still be employed.
- numerous of the downstream mixers 1404 and 1406 are required.
- a further potentially beneficial implementation of parallel mixing systems occurs when various desired gum structures are formed by, at least, the mixture of two or more similar gum structures.
- two gum bases may be blended together to form a third desired gum base.
- mixing systems such as mixing system 1500 can be used where mixer 1502 and mixer 1504 produce the first and second gum bases, respectively, and the two gum bases are then blended together in downstream mixer 1506.
- parallel mixing systems 1400, 1500, 1600 will be described with reference to mixing systems 2700-3300, illustrated in FIGS. 27-33. While the following examples will show the use of particular arrangements of parallel mixing systems incorporating varying combinations and arrangements of continuous or batch mixers, these representative contemplated examples are not intended to be limiting.
- Other parallel mixing systems in accord with the present invention may include more or less mixers arranged in a parallel arrangement or may have more or less mixers aligned upstream or downstream from the parallel arrangements.
- FIG. 27 a first particular parallel mixing system 2700 is shown. This first system 2700 will be explained in detail, while other embodiments illustrated in FIGS. 28-33 will be discussed and described in more limited detail highlighting differences and similarities relative to system 2700.
- Mixing system 2700 is a more particular example of the general mixing system 1400 illustrated schematically in FIG. 14, generically discussed previously.
- System 2700 includes three continuous mixers 2704, 2706, 2708 arranged in parallel with each other.
- System 2700 further includes a continuous mixer 2702 arranged in series and upstream of the three parallel mixers 2704, 2706, 2708, and a single continuous mixer 2710 in series with and downstream of each of the three parallel mixers 2704, 2706, 2708.
- effluent of continuous mixer 2702 is used as an ingredient for the gum structures that are formed by parallel mixers 2704, 2706, 2708.
- Each of the effluents of mixers 2704, 2706, 2708 can be fed as an ingredient to mixer 2710.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 2704 may be recirculated as an ingredient to mixer 2702 or fed to mixer 2706 and 2708 which are arranged in parallel with mixer 2704.
- mixers 2702, 2704, 2706, 2708, 2710 are equipped with ingredient feeders 2712, 2714, 2716, 2718.
- the number, arrangement and type of ingredient feeders are selected according to characteristics of ingredients to be processed in each mixer for continuous delivery of the ingredients to the continuous mixer at desired feed rates.
- FIG. 27 depicts mixer 2702 with seven feed ports 2720, 2722, 2724, 2726, 2728, 2730, 2732; mixer 2704 with five feed ports 2734, 2736, 2738, 2740, 2742; mixer 2706 with five feed ports 2744, 2746, 2748, 2750, 2752; mixer 2708 with five feed ports 2754, 2756, 2758, 2760, 2762; and mixer 2710 with five feed ports 2764, 2766, 2768, 2770, 2772.
- each mixer can be configured with any number of feed ports.
- mixing system 2700 is used to form a desired finished gum base FGB4, which can then be processed using a different mixing system to form a finished gum.
- Mixer 2702 forms a gum structure that is less than a gum base.
- Mixers 2704, 2706, 2708 each produce a gum structure in the form of differing finished gum bases FGBl, FGB2, FGB3.
- Mixer 2710 combines the different finished gum bases FGBl, FGB2, FGB3 of mixers 2704, 2706, 2708 to produce a desired finished gum base FGB4 which is different than the finished gum bases FGBl, FGB2, FGB3 produced by mixers 2704, 2706, 2708, respectively.
- mixer 2702 is configured as a high shear, high temperature extruder to compound the elastomeric portion of a set of gum base ingredients GBIx.
- the set of gum base ingredients GBIx added to mixer 2702 may consist of various molecular weight elastomers including butyl rubber, polyvinyl acetate, polyisobutylene, and elastomer plasticizer in the form of rosin ester and waxes as listed in Table 2.
- each ingredient of the set of gum base ingredients GBIx is added to mixer 2702 using an ingredient feeder such as one depicted with reference number 2712.
- FIG. 27 only shows one ingredient feeder 2712 for mixer 2702, it is contemplated that any number of ingredient feeders, such as five ingredient feeders in this case, for each ingredient of GBIx, may be used for continuous delivery of ingredients to mixer 2702.
- the ingredients of GBIx may be added all at one location or at different locations of mixer 2702. However, typically, higher molecular weight elastomer requiring longer residence time will be added first.
- high molecular weight elastomer such as butyl rubber
- the other elastomers such as polyvinyl acetate and polyisobutylene
- rosin ester and waxes may be added to feed port 2724 or other subsequent feed ports 2726, 2728, 2730, 2732.
- ingredient feeders 2712 continuously feed GBIx to mixer 2702.
- feed rate of each ingredient of GBIx to mixer 2702 may be 80 kg/hr butyl rubber, 46.7 kg/hr polyvinyl acetate, 93.3 kg/hr polyisobutylene, 48 kg/hr rosin ester and 92 kg/hr waxes.
- mixer 2702 outputs 360 kg/hr of a compounded elastomer consisting of the set of gum base ingredients GBIx.
- Three more sets of gum base ingredients GBIyI, GBIy2, GBIy3 are also fed to mixers 2704, 2706, 2708, respectively.
- a set of gum base ingredients GBIyI is added with a portion of the effluent of mixer 2702 consisting of GBIx to produce a finished gum base FGB 1 consisting of GBIxy 1.
- the set of gum base ingredients GBIyI includes additional gum base ingredients of GBIx and other gum base ingredients to form a gum base formulation within the ranges specified for Representative Gum Base 2 of Table 2.
- mixer 2704 may be configured with lesser shear elements than mixer 2702, but still equipped with elements sufficient for dispersive mixing of additional low molecular weight elastomers with the effluent of mixer 2702 and other gum base ingredients.
- a feed rate of each ingredient of the set of gum base ingredients GBIyI in this example is 48.3 kg/hr polyvinyl acetate, 6.7 kg/hr polyisobutylene, 12 kg/hr rosin esters, 8 kg/hr waxes, 75 kg/hr vegetable oils, 30 kg/hr emulsifier in the form of triacetin, and 30 kg/hr calcium carbonate filler.
- mixer 2704 forms 305 kg/hr of finished gum base FGBl consisting of GBIxy 1.
- the sets of ingredients processed in mixers 2702, 2704, 2706, 2708, 2710 of this implementation are for illustrative purpose only.
- Ingredients to be processed in each mixer of a gum mixing system such as system 2700 are selected according to many factors such as viscosity and other characteristics of ingredient including a form in which the ingredient is inputted into a mixer, i.e. liquid, solid blocks, powder, etc.
- viscosity and other characteristics of ingredient including a form in which the ingredient is inputted into a mixer, i.e. liquid, solid blocks, powder, etc.
- any high viscosity ingredients fed to downstream mixers such as mixer 2704 may be fed in a liquid form.
- mixers 2706 and 2708 are each fed continuously with 37.5% of the effluent of mixer 2702 and an additional set of gum base ingredients GBIy2 or GBIy3 consisting of vegetable oil, emulsifier in the form of lecithin or glycerol monostearate, and calcium carbonate, thereby forming a finished gum base FGB2 consisting of GBIxy2 and a different finished gum base FGB3 consisting of GBIxy3.
- Finished gum bases FGB2 and FGB3 are both different formulations of Representative Gum Base 1 in Table 2. Because GBIy2 and GBIy3 do not include additional elastomers, mixers 2706 and 2708 may be operated at a higher speed than the other parallel mixer 2704. Therefore, mixers 2706 and 2708 have a higher throughput rate than mixer 2704 as will be explained below.
- Feed rates of ingredients to mixer 2706 include a portion of the effluent from mixer 2702 consisting of 30 kg/hr butyl rubber, 17.5 kg/hr polyvinyl acetate, 35 kg/hr polyisobutylene, 18 kg/hr rosin ester and 34.5 kg/hr waxes and GBIy2 consisting of 57.5 kg/hr vegetable oil, 25 kg/hr emulsifier in the form of lecithin, and 130 kg/hr calcium carbonate as a filler.
- feed rates of ingredients to mixer 2708 include a portion of the effluent from mixer 2702 consisting of 30 kg/hr butyl rubber, 17.5 kg/hr polyvinyl acetate, 35 kg/hr polyisobutylene, 18 kg/hr rosin esters and 34.5 kg/hr waxes and GBIy3 consisting of 57.5 kg/hr vegetable oil, 25 kg/hr emulsifier in the form of glycerol monostearate, and 130 kg/hr calcium carbonate filler. Therefore, mixer 2706 processes 347.5 kg/hr of GBIxy2 to form FGB2, and mixer 2708 processes 347.5 kg/hr of GBIxy3 to form FGB3.
- feed rates of the effluents consisting of GBIxy2 and GBIxy3 are both 347.5 kg/hr corresponding to the throughput rates of mixers 2706 and 2708.
- mixer 2710 forms 1000 kg/hr of the finished gum base FGB4 consisting of GBIxy Iy2y3.
- the ingredients and their quantities constituting the effluents of mixers 2702, 2704, 2706, 2708 are summarized in Table 8. More particularly, the quantity of each ingredient in Table 8 is represented in terms of weight percentage of each ingredient based on the corresponding set of input ingredients.
- a set of gum base ingredients GBIx which forms less than a gum base in mixer 2702, is comprised of 22% butyl rubber, 13% polyvinyl acetate, 26% polyisobutylene, 13% rosin esters and 26% waxes by weight.
- finished gum bases FGBl, FGB2, FGB3, FGB4 are gum base formulations of Representative Gum Bases listed in Table 2; FGBl is a Representative Gum Base 2 formulation, and FGB2, FGB3, FGB4 are Representative Gum Base 1 formulations.
- system 2700 is designed such that all of the effluent of mixer 2702 consisting of GBIx is processed simultaneously in three parallel downstream mixers 2704, 2706, 2708.
- mixer 2702 may be configured to have a larger production capacity, producing excess effluent consisting of GBIx.
- Such excess effluent may be processed in additional downstream mixers to produce different gum bases than FGB2, FGB3, FGB4, for example, gum base formulations listed as Representative Gum Bases 4 and 5 which include talc as a filler instead of calcium carbonate.
- the effluent of mixer 2702 consisting of the set of ingredients GBIx do not include any calcium carbonate which may be incomparable with gum base formulations including talc as a filler.
- mixers 2704, 2706, 2708 can also be configured to produce excess effluents FGBl, FGB2, FGB3 such that each effluent may be used to form a different finished gum including a different gum base having a set of gum base ingredients GBIxyl, GBIxy2, or GBIxy3. Therefore, parallel systems, such as system 2700, enable production of numerous different gum formulations using a single gum mixing system to better respond to fluctuating market demands.
- system 2700 may be assembled as a process line with mixers 2702, 2704, 2706, 2708, 2710 in a single section of a manufacturing plant, it is also contemplated that all or some of the mixers may be located remotely from one another, either in different sections of the same manufacturing plant or in different manufacturing plants in different cities or even different countries.
- mixers 2702, 2704, 2706, 2708 may be located in Plant 1 and mixer 2710 may be located in Plant 2.
- transportation of the effluents from mixers 2704, 2706, 2708 in Plant 1 to mixer 2710 in Plant 2 has to be coordinated as described in the discussions relating to kitting of series mixing systems above.
- the mixers of Plant 1 may manufacture large quantities of FGBl, FGB2 and FGB3, which can be processed with sets of subsequent gum ingredients to produce finished gums.
- FGBl, FGB2 and FGB3 may be combined as desired by a downstream user, such as at local Plant 2, to form a separate gum base FGB4.
- mixers of parallel systems can process numerous different combinations of ingredients to produce various effluents.
- mixer 2702 is not limited to producing a gum structure less than a gum base such as GBIx in the example discussed above, but may produce a premix, a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with subsequent gum ingredients, an elastomer with some other gum base ingredients and some subsequent gum ingredients, a gum base, or a gum base with subsequent gum ingredients.
- mixers 2704, 2706, 2708 can also produce any gum structures less than a gum base including a compounded elastomer, an elastomer with other gum base ingredients, an elastomer with subsequent gum ingredients, an elastomer with some other gum base ingredients and some subsequent gum ingredients, a gum base, or a gum base with subsequent gum ingredients.
- Mixer 2710 can also process different combinations of ingredients to output different effluents including a finished gum.
- mixers 2704, 2706, 2708 as running simultaneously and feeding their effluents simultaneously to mixer 2710 as ingredients for the gum structure FGB4
- other implementations may have mixers 2704, 2706, 2708 sequentially feeding mixer 2710.
- the gum structure effluent of mixer 2710 need not be formed by utilizing effluents of all of mixers 2704, 2706, 2708.
- mixer 2710 may sequentially produce different finished gum formulations by sequentially receiving different gum bases from mixers 2704, 2706, 2708, and processing each gum base with a set of subsequent gum ingredients.
- two of three mixers 2704, 2706, 2708 may run simultaneously while the other mixer runs sequentially with the two simultaneously running mixers.
- mixer 2704 and mixer 2706 may run simultaneously producing two different gum structures, which may feed mixer 2710 simultaneously or sequentially.
- Mixer 2708 may not run while mixers 2704, 2706 are in operation, and may only run while mixers 2704, 2706 are down for configuration changes, cleaning or other reasons.
- mixer 2702 may feed mixers 2704, 2706, 2708, sequentially. That is, mixer 2702 may feed a surge tank (not shown), for a set period of time, which holds the effluent of mixer 2702 and continuously feeds mixer 2704. For the next set period of time, mixer 2702 feeds a second surge tank (not shown) which holds the effluent of mixer 2702 and continuously feeds mixer 2706. Finally, mixer 2702 feeds a third surge tank (not shown) which holds the effluent of mixer 2702 and continuously feeds mixer 2708. Alternatively, mixer 2702 may feed two mixers simultaneously and one mixer sequentially to the feeding of the other two mixers.
- mixers 2704, 2706, 2708 are all identical and form a same gum structure.
- mixer 2702 may be producing a gum base master batch which is fed to mixers 2704, 2706, 2708, sequentially or simultaneously.
- Mixers 2704, 2706, 2708 receive the gum base master batch from mixer 2702 and may process it with the same set of gum base ingredients to produce the same gum base.
- mixers 2704, 2706, 2708 may produce different gum bases as described above, or may produce different gum structures.
- mixer 2704 may output a gum base
- mixer 2706 may output, a compounded elastomer with at least one subsequent gum ingredient
- mixer 2708 may produce a gum base with at least one subsequent gum base.
- FIG. 28 A second particular parallel mixing system 2800 is illustrated in FIG. 28.
- System 2800 is similar to system 2700 in that both systems include three mixers arranged in parallel with each other and series with an upstream mixer and a downstream mixer.
- the parallel mixers 2804, 2806, 2808 of system 2800 are batch mixers rather than continuous mixers 2704, 2706, 2708 of system 2700.
- the upstream series mixer 2802 and downstream series mixer 2810 remain as continuous mixers.
- Each mixer 2802, 2804, 2806, 2808, 2810 can be provided with any number of ingredient feeders, and the continuous mixers 2802, 2810 can be configured with any number of feed ports as discussed previously for system 2700 and the series mixing systems.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 2810 may be recirculated as an ingredient of mixer 2804 or effluent of mixer 2808 may be fed as an ingredient to mixer 2804 and/or mixer 2806.
- Mixers of system 2800 may produce the same effluents produced by mixers of system 2700. That is, system 2800 can be configured so that mixer 2802 outputs an effluent consisting of GBIx, and mixers 2804, 2806, 2808, 2810 produce effluents consisting of FGBl, FGB2, FGB3, FGB4, respectively. However, mixers of system 2800 can also produce different effluents. For example, mixer 2802 may produce a gum structure less than a gum base, each one of mixers 2804, 2806, 2808 may output a same finished gum base FGB5, and mixer 2810 may produce a finished gum FG.
- mixer 2802 is an extruder configured for high shear dispersive mixing for compounding elastomers with at least one compounding aid.
- Mixer 2802 processes a set of gum base ingredients GBIx which includes some gum base ingredients, but not all of the gum base ingredients necessary to produce a desired finished gum base.
- GBIx may consist of butyl rubber, polyvinyl acetate, polyisobutylene, rosin esters, waxes and vegetable oils.
- the effluent of mixer 2802 produced by mixing the set of gum base ingredients GBIx is, thus, a gum structure less than a finished gum base as it is void of any fillers.
- the effluent of mixer 2802 is further processed in batch mixers 2804, 2806, 2808 in separate portions as an ingredient, wherein the effluent including the set of gum base ingredients GBIx is combined with another set of gum base ingredients GBIy to output a finished gum base, FGB5.
- the effluents of mixers 2804, 2806, 2808, namely FGB5 are then fed to mixer 2810 as ingredients with a set of subsequent gum ingredients SGIz producing a finished gum FG.
- upstream mixer 2802 and downstream mixer 2810 are mixers having large enough capacities to supply multiple midstream mixers and process effluents from those multiple midstream mixers.
- mixer 2802 may process 1000 kg/hr of GBIx consisting of 89.7 kg/hr butyl rubber, 256.4 kg/hr polyvinyl acetate, 76.9 kg/hr polyisobutylene, 384.6 kg/hr rosin esters, 128.2 kg/hr waxes, and 64.2 kg/hr vegetable oil.
- the effluent of mixer 2802 consisting of GBIx is then fed to three parallel downstream batch mixers 2804, 2806, 2808 sequentially according to the capacity of each mixer. For example, when mixer 2804, 2806, 2808 are each equal in its capacity, the effluent of mixer 2802 consisting of GBIx can be first directed to mixer 2804 for 15 minutes to feed 250 kg of the effluent consisting of GBIx.
- the set of gum base ingredients GBIy including 6 kg of triacetin and 64 kg of talc filler is also added to mixer 2804, then mixer 2804 runs for a batch run time of 20 minutes.
- Mixer 2802 effluent starts to feed mixer 2806; GBI y also added to mixer
- Mixer 2802 effluent starts to feed mixer 2808; GBI y also added to mixer
- Mixer 2804 cleaned (if necessary” for next batch set-up.
- Mixer 2802 effluent starts to feed mixer 2804; GBI y also added to mixer
- Mixer 2806 cleaned (if necessary) for next batch set-up.
- Mixer 2802 effluent starts to feed mixer 2806; GBI y also added to mixer
- Mixer 2808 cleaned (if necessary) for next batch set-up.
- a batch set-up or batch run may be delayed for many reasons, i.e. mixer clean up, mixer maintenance, etc.
- each of batch mixer 2804, 2806, 2808 are provided with surge tank 2812, 2814, 2816 which can hold the effluent of mixer 2802 including GBIx until the mixer is ready for a batch set-up.
- the above discussed schedule provides for a sequential feeding of mixer 2810 from mixers 2804, 2806, 2808 with a rate of 320 kg of FGB5 per every 15 minutes or 1280 kg/hr.
- a set of subsequent gum ingredients SGIz including 646 kg/hr of sucrose, 216 kg/hr of corn syrup, 22 kg/hr of glycerin, 22 kg/hr of lecithin, 22 kg/hr of flavor, 22 kg/hr of acid, and 22 kg/hr of color is also fed to mixer 2810, wherein 2,152 kg/hr of FG is produced.
- the ingredients and their quantities constituting the effluents of mixers 2802, 2804, 2806, 2808, 2810 are summarized in Table 10. More particularly, the quantity of each ingredient in Table 10 is represented in terms of weight percentage of each ingredient relative to the corresponding set of input ingredients.
- the set of gum base ingredients GBIx is comprised of 9% butyl rubber, 25.6% polyvinyl acetate, 7.7% polyisobutylene, 38.5% rosin esters, 12.8% waxes and 6.4% vegetable oils.
- finished gum base FGB5 is a formulation of Representative Gum Base 4 listed in Table 2
- finished gum FG is a formulation of Finished Gum 9 listed in Table 3.
- mixers of system 2800 can process various combinations of ingredients to produce many different effluents. That is, each mixer in system 2800 may produce a gum structure other than what is described in the above example.
- mixer 2802 may produce a finished gum base which is supplied to mixers 2804, 2806, 2808, sequentially or simultaneously.
- Mixers 2804, 2806, 2808 may process the gum base from mixer 2802 with the same or a different set of subsequent gum ingredients to produce the same or different gum structures such as a gum base with some subsequent gum ingredients or a finished gum.
- Mixers arranged in parallel 2804, 2806, 2808 of above described implementation are all producing the same finished gum base, FGB5. However, these mixers can produce different finished gum bases, or produce a gum structure other than a finished gum, i.e. mixer 2804 can produce a compounded elastomer with at least one subsequent gum ingredient, while mixers 2806, 2808 may produce some other gum structure such as a gum base with at least one subsequent gum ingredient.
- mixer 2810 may produce different finished gums sequentially, each using a different finished gum base as an ingredient. Further, even when mixers 2804, 2806, 2808 produce the same gum structure less than a finished gum, such as the above described implementation, mixer 2810 may sequentially process a different set of subsequent gum ingredients with the effluents of mixers 2804, 2806, 2808 to produce different finished gum formulations sequentially, for example, finished gum formulations including different functional ingredients, different flavors, etc.
- mixers 2804, 2806, 2808 may simultaneously run to produce a same effluent or different effluents, or two of the three mixers may run simultaneously with the other one running sequentially.
- mixer 2804 and mixer 2806 may run simultaneously and mixer 2808 may run sequentially with mixers 2804, 2806.
- mixers 2804, 2806, 2808, 2810 may be in a different plant than where the plant mixer 2802 is located. Allowing fillers to be added where finished gums are manufactured may be advantageous since the weight of a gum base master batch such as GBIx is minimized, reducing transportation costs.
- System 2900 includes two continuous mixers 2904, 2908 and one batch mixer 2906 arranged in parallel to each other.
- System 2900 further includes a batch mixer 2902 arranged in series with and upstream of each of the three parallel mixers 2904, 2906, 2908. According to this arrangement, effluent of batch mixer 2902 is used as an ingredient for gum structures that are formed by parallel mixers 2904, 2906, 2908.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 2906 may be recirculated back into mixer 2906 as an ingredient, or may be fed to mixer 2904 and/or mixer 2908.
- a contemplated example of such an implementation is where mixer 2902 produces a large quantity of a gum base master batch, which is then transported in separate portions to downstream mixers in plants in different locations.
- batch mixer 2902 may process a set of gum base ingredients GBIx to produce a desired gum base master batch including 12.5% styrene-butadiene rubber, 31.25% polyvinyl acetate, 25% rosin esters, 12.5% waxes, 12.5% vegetable oils, and 6.25% of triacetin (all in weight percentage of the desired gum base master batch produced by mixer 2902).
- This gum base master batch is a gum structure less than a gum base, more particularly, a gum base formulation of Representative Gum Base 3 of Table 3, less calcium carbonate filler.
- the gum base master batch is made such that it is storable and transportable as described above for a kitting operation.
- mixer 2902 which produces the gum base master batch
- plant 2910 the gum base master batch is transported from plant 2910 to plants 2912, 2914, 2916 in equal portions to be processed in mixer 2904, 2906, 2908, respectively, with additional ingredients to form finished gums.
- the gum base master batch will constitute 24% by weight of total ingredients processed in the mixer.
- the other 76% by weight of ingredients include 6% calcium carbonate filler (constituting a set of gum base ingredients GBIy), 25% sucrose, 12% corn syrup, 2% hydrogenated starch hydrolysates, 18% sorbitol, 5% erythritol, 2% glycerin, 5% lecithin, 0.9% flavor, and 0.1% color (constituting a set of subsequent gum ingredients SGIy).
- 30% by weight of the effluent of each mixer 2904, 2906, 2908 is a gum base including the gum base master batch consisting of GBIx, and the set of gum base ingredients GBIy consisting of calcium carbonate. It is noted that the effluents of mixers 2904, 2906, 2908, which are finished gum FG, are a gum formulation of Finished Gum Composition 8 of Table 3.
- Such an implementation is advantageous where a gum base master batch is produced in large quantities at a central plant and transported to different locations for producing finished gums according to local market demand. Producing a gum base master batch rather than a gum base and adding a filler at local plants is also advantageous as it reduces bulk weight of transportation and may be cost effective as the bulk filler ingredients may be acquired locally at a lower cost.
- mixer 2904 may produce a sugarless finished gum formulation only including polyol bulk sweeteners such as sorbitol, xylitol, isomalt, etc.
- mixer 2906 is outputting a finished gum including a sugar
- mixer 2908 is producing a yet different sugarless finished gum formulation including polyols and some functional ingredients such as menthol.
- mixers 2904, 2906, 2908 may produce finished gum formulations which may include the same ingredients except that they may include different flavors, colors or sensate ingredients such as cooling agents, warming agents, tingling agents, etc.
- system 2900 may be designed to produce other gum structures, for example, one of the downstream parallel mixer may produce a gum base while other two mixers produce a gum base including some subsequent gum ingredients.
- the upstream mixer 2902 may produce a different gum structure such as a finished gum base which feeds mixers 2904, 2906, 2908, sequentially or simultaneously to produce the same gum structure such as the finished gum in the above described implementation, or different gum structures, i.e. mixer 2904 may produce a gum base with a set of subsequent gum ingredients, mixer 2906 may produce a finished gum base which is different than the gum base from 2902, and mixer 2908 may produce a finished gum.
- mixers 2904, 2906, 2908 When one or more downstream mixers 2904, 2906, 2908 produce a gum structure less than a finished gum, one or more mixers arranged in series and downstream from mixers 2904, 2906, 2908 may be added to system 2900 to produce one or more finished gums. Of course, all or some of mixers in system 2900 may be located in the same plant.
- Mixer 2902 may feed mixers 2904, 2906, 2908 simultaneously or sequentially.
- mixers 2904, 2906, 2908 may output effluents simultaneously or sequentially.
- System 3000 includes three batch mixers 3002, 3004, 3006 arranged in parallel with each other.
- System 3000 further includes a continuous mixer 3008 in series with and downstream of each of the three parallel mixers 3002, 3004, 3006.
- effluents of the parallel mixers 3002, 3004, 3006 are used as ingredients for a gum structure formed in mixer 3008.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 3008 may be recirculated as an ingredient of mixer 3002, 3004, and/or 3006, or effluent of mixer 3002 may be fed as an ingredient to mixer 3004 and/or mixer 3006.
- batch mixers 3002, 3004, 3006 form a gum structure which is less than a gum base including a subsequent gum ingredient from a set of gum base ingredients GBIx and a set of subsequent gum ingredients SGIx.
- the effluents from mixers 3002, 3004, 3006 are then transported to surge tank 3010 to be continuously fed to mixer 3008.
- Mixer 3008 receives the effluents from mixers 3002, 3004, 3006 along with a set of gum base ingredients GBIy and a set of subsequent gum ingredients SGIy to produce a finished gum FG.
- Such implementation may be advantageous because existing batch mixers can be combined as parallel mixers to sequentially feed a downstream, high capacity, continuous mixer, such as mixer 3008 in system 3000.
- mixers 3002 and 3004 are smaller capacity batch mixers than mixer 3006.
- the smaller capacity mixers 3002, 3004 are paired and then the combination acts in parallel with mixer 3006.
- batches can be scheduled so that mixers 3002, 3004 are running sequentially with mixer 3006. That is, mixers 3002, 3004 can start their batches first, and while those batches are in progress, mixer 3006 is prepared for its batch run.
- mixers 3002, 3004 are completed with their batches, mixer 3006 can start its batch,and while mixer 3006 batch is running, effluents of mixers 3002, 3004 are emptied and transported to mixer 3008. Then mixers 3002, 3004 are cleaned, if necessary, and prepared for the next batchand the process cycle repeats.
- a cycle of the contemplated process schedule for such implementation of system 3000 is summarized in Table 12.
- Mixer 3006 batch set-up.
- Mixer 3006 starts batch.
- Mixers 3002, 3004 emptied; effluents transported to mixer 3008; mixers 3002, 3004 batch set-up.
- Mixers 3002, 3004 start batches.
- Mixer 3006 emptied; effluent transported to mixer 3008; mixer 3006 batch setup.
- Mixer 3006 starts batch.
- Mixers 3002, 3004 emptied; effluents transported to mixer 3008; mixers 3002, 3004 batch set-up. [0557]
- the process schedule of Table 12 provides a sequential feed of mixer 3008 from mixers 3002, 3004 and mixer 3006 in 30 minute intervals.
- each of mixers 3002, 3004 is 50% capacity of mixer 3006.
- mixers 3002, 3004 combined supply the same amount of effluent as mixer 3006.
- each of mixers 3002, 3004 may process, per batch, a set of gum base ingredients GBIx including 7 kg butyl rubber, 20 kg polyvinyl acetate, 13 kg polyisobutylene, 5 kg rosin esters, 5 kg waxes, 25 kg vegetable oil, and a set of subsequent gum ingredients SGIx consisting of 196.7 kg sorbitol.
- each of mixers 3002, 3004 produces 271.7 kg of a gum structure which is less than a gum base including a subsequent gum ingredient consisting of GBIx+SGIx. Therefore, mixers 3002 and 3004 combined provide 543.4 kg of effluent consisting of GBIx+SGIx to mixer 3008 every 30 minutes (i.e. each batch) according to the process schedule of Table 12.
- mixer 3006 may process the same set of gum base ingredients GBIx and the same set of subsequent gum ingredients SGIx, but in double quantities, i.e. 14 kg of butyl rubber, 40 kg of polyvinyl acetate, 26 kg of polyisobutylene, 10 kg of rosin esters, 10 kg of waxes, 50 kg of vegetable oil, and 393.4 kg of sorbitol, producing 543.4 kg of a gum structure, which is less than a gum base including a subsequent gum ingredient consisting of GBIx+SGIx.
- mixer 3006 also provides 543.4 kg of effluent consisting of GBIx+SGIx to mixer 3008 every 30 minutes according to the process schedule of Table 12.
- the effluents from mixers 3002, 3004, 3006 are then transported to surge tank 3010 for continuous feed to mixer 3008.
- Surge tank 3010 receives 543.4 kg of effluent consisting of GBIx+SGIx from mixers 3002, 3004, and mixer 3006, sequentially, every 30 minutes.
- Surge tank 3010 holds the effluent for continuous feeding of the effluent along with the set of gum base ingredients GBIy and the set of subsequent gum ingredients SGIy to mixer 3008.
- surge tank 3010 continuously feeds 1086.8 kg/hr of GBIx+SGIx to mixer 3008, as other ingredient feeders, such as ingredient feeder 3012, feed the set of gum base ingredients GBIy consisting of 20 kg/hr of lecithin, 80 kg/hr of talc, and the set of subsequent gum ingredients SGIy including 13.4 kg/hr of hydrogenated starch hydrolysates, 13.4 kg/hr of glycerin, 66.6 kg/hr of lecithin, 50.6 kg/hr of flavor, 2.6 kg/hr of color, producing 1333.4 kg/hr of finished gum FG, which is a formulation of Finished Gum Composition 10 in Table 3.
- each of mixers in system 3000 can process numerous different combinations of gum ingredients to output different effluents.
- mixer 3002 may produce a compounded elastomer
- mixer 3004 may produce a finished gum base
- mixer 3006 may produce a gum base master batch which includes compounded elastomer with some additional gum base ingredients.
- Mixers 3002, 3004, 3006 may all run simultaneously or sequentially, or two of three mixers may run simultaneously at a give time.
- Mixer 3008 may be fed with effluents of mixers 3002, 3004, 3006 simultaneously or sequentially via a combination of surge tanks and/or ingredient feeders. For example, mixer 3008 may process the compounded elastomer from mixer 3002 with a set of gum base ingredients for a period of time to produce a finished gum base. Next, mixer 3008 may process the finished gum base with a set of subsequent gum ingredients to produce a finished gum for a period of time. Finally, mixer 3008 may process the gum base master batch from mixer 3006 with a set of subsequent gum ingredients to produce a gum base master batch with some subsequent gum ingredients for a period of time, and the sequential process cycles.
- effluents from mixers 3002, 3004, 3006 may be fed to mixer 3008 simultaneously.
- the compounded elastomer from mixer 3002 and the gum base master batch from mixer 3006 may be simultaneously fed to mixer 3008 as ingredients wherein other gum ingredients are added and processed to produce a gum structure such as a finished gum base or a finished gum.
- mixers in system 3002 may be located in different parts of a plant or different plants.
- System 3100 is different from system 3000 in that it includes three parallel mixers 3102, 3104, 3106 that are continuous mixers rather than batch mixers, such as mixers 3002, 3004, 3006 of system 3000.
- System 3100 further includes a batch mixer 3108 in series with and downstream of each of the three parallel mixers 3102, 3104, 3106, and a continuous mixer 3110 in series with and downstream of mixer 3108.
- effluents of the parallel mixers 3102, 3104, 3106 are used as ingredients for a gum structure formed in mixer 3108, which then is used as an ingredient of mixer 3110.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 3110 may be recirculated as an ingredient of mixer 3108 or effluent of mixer 3102 may be fed as an ingredient to mixer 3104 and/or mixer 3106.
- mixers 3102, 3104, 3106 may form a gum structure which is less than a gum base from a set of gum base ingredients GBIx. Effluents from mixers 3102, 3104, 3106 are then transported to surge tank 3121 to be held until mixer 3108 is ready for a batch set-up, such as while mixer 3108 is mixing a previously loaded set of ingredients. Mixer 3108 combines the effluent consisting of GBIx with an additional set of gum base ingredients GBIy to produce a desired finished gum base FGB. The effluent of 3108 FGB is then transported to surge tank 3114 for continuous feed to mixer 3110, wherein FGB is processed with a set of subsequent gum ingredients SGIx, producing a finished gum FG.
- Such an implementation may be advantageous where the elastomer compounding portion of the gum making process, which may be the most time consuming step of a batch gum making process, is performed by multiple continuous mixers to reduce the time required for the overall gum making process.
- an elastomer compounding process may require 30 minutes of batch run time to produce 100 kg of a compounded elastomer in a batch mixer.
- Such process time can be reduced by using continuous parallel mixers, such as mixers 3102, 3104, 3106, which may process 100 kg of the compounded elastomer in 10 minutes when combined.
- each of mixers 3102, 3104, 3106 may continuously compound 200 kg/hr of elastomer by processing the set of gum base ingredients GBIx consisting of 36.4 kg/hr butyl rubber, 18.2 kg/hr polyvinyl acetate, 36.4 kg/hr polyisobutylene, 18.2 kg/hr rosin esters, 36.4 kg/hr wax, and 54.4 kg/hr vegetable oil.
- GBIx consisting of 36.4 kg/hr butyl rubber, 18.2 kg/hr polyvinyl acetate, 36.4 kg/hr polyisobutylene, 18.2 kg/hr rosin esters, 36.4 kg/hr wax, and 54.4 kg/hr vegetable oil.
- GBIx consisting of 36.4 kg/hr butyl rubber, 18.2 kg/hr polyvinyl acetate, 36.4 kg/hr polyisobutylene, 18.2 kg/hr rosin esters, 36.4 kg/hr wax, and 54.4 kg
- Surge tank 3112 holds the effluents until mixer 3108 is ready for a batch set-up and delivers the effluents, which is then further processed with an additional set of gum base ingredients GBIy in mixer 3108 to produce a finished gum base FGB.
- mixer 3108 may start a new batch every 20 minutes.
- a batch of mixer 3108 can include 200 kg of GBIx and 163.7 kg of GBIy consisting of 18.2 kg triacetin and 145.5 kg calcium carbonate.
- the batch of mixer 3108 runs for 18 minutes producing finished gum base FGB which is a formulation of Representative Gum Base 1 in Table 2.
- effluent FGB is delivered to surge tank 3114 for continuous feed of FGB to mixer 3110, and mixer 3108 is prepared for the next batch.
- the batch cycle is scheduled every 20 minutes.
- Surge tank 3114 thus receives 363.7 kg of FGB every 20 minutes from mixer 3108, or 1091.1 kg/hr of FGB. Therefore, mixer 3110 can receive 1091.1 kg/hr of FGB and 727.5 kg/hr of the set of subsequent gum ingredients SGIz consisting of 545.6 kg/hr sucrose, 90.9 kg/hr corn syrup, 18.2 kg/hr glycerin, 18.2 kg/hr lecithin, 36.4 kg/hr flavor, 16.4 kg/hr acid, and 1.8 kg/hr color to produce 1818.6 kg/hr of finished gum FG.
- SGIz consisting of 545.6 kg/hr sucrose, 90.9 kg/hr corn syrup, 18.2 kg/hr glycerin, 18.2 kg/hr lecithin, 36.4 kg/hr flavor, 16.4 kg/hr acid, and 1.8 kg/hr color to produce 1818.6 kg/hr of finished gum FG.
- the ingredients and their quantities constituting the effluents of mixers 3102, 3104, 3106, 3108, 3110 are summarized in Table 14. More particularly, the quantity of each ingredient in Table 14 is represented in terms of weight percentage of each ingredient relative to the corresponding set of input ingredients.
- a set of gum base ingredients GBIx is comprised of 18.2% butyl rubber, 9.1% polyvinyl acetate, 18.2% polyisobutylene, 9.1% rosin esters, 18.2% waxes and 27.2% vegetable oils.
- finished gum base FGB is a formulation of Representative Gum Base 1 listed in Table 2
- finished gum FG is a formulation of Finished Gum 6 listed in Table 3.
- each of mixers in system 3100 can process numerous different combinations of gum ingredients to output different effluents, simultaneously or sequentially.
- mixer 3102 may produce a compounded elastomer
- mixer 3104 may produce a finished gum base
- mixer 3106 may produce a gum base master batch which includes compounded elastomer with some additional gum base ingredients.
- Mixers 3102, 3104, 3106 may run all simultaneously or sequentially or two of three mixers may run simultaneously at a give time.
- Mixer 3108 may process effluents from mixers 3102, 3104, 3106 simultaneously or sequentially. For example, mixer 3108 may process each effluent of mixers 3102, 3104, 3106 sequentially with additional gum ingredients to sequentially output different gum structures which are less than a finished gum, or mixer 3108 may simultaneously process two of effluents of mixers 3102, 3104, 3106 with or without additional gum ingredients to produce gum structures less than a finished gum. Finally, mixer 3108 may simultaneously process all three effluents from mixers 3102, 3104, 3106 with or without additional gum ingredients to produce a gum structure less than a finished gum. According to the effluent supplied by mixer 3108 and additional gum ingredients, mixer 3110 may produce many different gum structures.
- mixers of system 3100 may be located in one or more different plants.
- System 3200 includes a batch mixer 3202 and a continuous mixer 3204 arranged in parallel with each other.
- System 3200 further includes a continuous mixer 3206 and a batch mixer 3208 arranged in parallel with each other and in series with and downstream of each of the parallel mixers 3202, 3204.
- effluents of the parallel mixers 3202, 3204 can be used, together or sequentially, as ingredients for gum structures formed in downstream mixers 3206, 3208.
- this type of mixing system can provide significant redundancy advantages should one mixer need cleaning or maintenance, and alternatively provide the best mixing process for mixing different sets of gum ingredients.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer or an effluent from a mixer may be direct to a downstream mixer of a mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 3206 may be recirculated as an ingredient of mixer 3202 and/or mixer 3204.
- effluent of mixer 3202 may be fed as an ingredient to mixer 3208 which is arranged in series and downstream of mixer 3204 arranged in parallel with mixer 3202.
- mixers 3202, 3204, 3206, 3208 may be located in different plants 3210, 3212, 3214, 3216.
- Plant 3210 may have a batch mixer 3202 which may produce a gum base master batch, GBMBl
- plant 3212 may have a continuous mixer 3204 which may produce a different gum base master batch, GBMB2.
- a mixer is selected to maximize process efficiency and product quality. For example, ingredients of GBMB 1 may process better in a batch mixer to produce a more consistent gum base master batch, while ingredients of GBMB2 may compound better in a continuous mixer.
- the location of plant 3210 may be closer to plant 3214 which utilizes a larger quantity of GBMBl than the plant 3216. In such a case, mixer 3202 of plant 3210 is scheduled to produce GBMBl so that transportation costs may be reduced.
- mixer 3202 produces a 600 kg batch of gum base master batch GBMBl from a set of gum base ingredients GBIxI consisting of 80 kg butyl rubber, 100 kg polyvinyl acetate, 100 kg polyisobutylene, 200 kg rosin esters, 50 kg wax, 50 kg vegetable oil and 20 kg triacetin.
- a batch cycle may be scheduled such that mixer 3202 produces 600 kg/hr of GBMBl, for example, 45 minutes of batch run coupled with 15 minutes of batch preparation time.
- mixer 3204 may produce 880 kg/hr of gum base master batch GBMB2 from continuous feed of a set of gum base ingredients GB 1x2 consisting of 80 kg/hr butyl rubber, 200 kg/hr polyvinyl acetate, 100 kg/hr polyisobutylene, 100 kg/hr rosin esters, 100 kg/hr wax, 250 kg/hr vegetable oil and 50 kg/hr triacetin.
- the downstream mixers 3206, 3208 receive effluents of mixers 3202, 3204, sequentially, to produce different finished gum bases.
- each of mixers 3206, 3208 may be dedicated such that mixer 3206 never processes a particular ingredient which is processed in mixer 3208, and mixer 3208 never processes a different particular ingredient which is processed in mixer 3206.
- mixer 3206 may only produce finished gum bases which include calcium carbonate as a filler, and mixer 3208 may only produce finished gum bases which include talc as a filler.
- Such implementation is advantageous since a risk of contamination by processing incompatible ingredients in a same mixer can be eliminated.
- Mixers 3206, 3208 can be scheduled according to a local market demand to produce different formulations of finished gum bases. For example, if the local demand of plant 3214 is with a finished gum utilizing a formulation of Representative Gum Base 1 of Table 2, GBMBl is delivered to plant 3214 from plant 3210. Then, mixer 3206 processes GBMBl with another a set of gum base ingredients GBIyI to produce finished gum base FGBl. Feed rates of ingredients are adjusted according to a desired output rate. For example, to produce 1000 kg/hr of finished gum base FGBl, mixer 3206 may process 600 kg/hr GBMBl with 50 kg/hr vegetable oil, 10 kg/hr triacetin, and 340 kg/hr calcium carbonate.
- the local market demand may fluctuate for many reasons. For example, it may fluctuate seasonally.
- GBMB2 is delivered to plant 3214 from plant 3212.
- mixer 3206 processes GBMB2 with another set of gum base ingredients GBIy2 to produce finished gum base FGB2.
- Feed rates of ingredients are adjusted according to a desired output rate. For example, to produce 1000 kg/hr of finished gum base FGB2, mixer 3206 may process 880 kg/hr GBMB2 with 20 kg/hr triacetin and 100 kg/hr calcium carbonate.
- mixer 3208 in plant 3216 can be scheduled to produce different finished gum bases for various reasons.
- Mixer 3208 may produce a formulation of Representative Gum Base 4 with gum base master batch GBMBl from mixer 3202.
- a batch of mixer 3208 may include 600 kg GBMBl, 150 kg rosin esters, 50 kg waxes and 20 kg talc to produce 1000 kg of finished gum base FGB3.
- mixer 3008 may produce 1000 kg batch of finished gum base FGB4, which is a formulation of Representative Gum Base 5, with 880 kg of GBMB2 from mixer 3204 and 120 kg of talc.
- finished gum base FGBl is a formulation of Representative Gum Base 1
- finished gum base FGB2 is a formulation of Representative Gum Base 2
- finished gum base FGB3 is a formulation of Representative Gum Base 4
- finished gum base FGB4 is a formulation of Representative Gum Base 5 listed in Table 2.
- each of mixers in system 3200 can process numerous different combinations of gum ingredients to output different effluents, simultaneously or sequentially.
- mixer 3202 may produce a finished gum base and mixer 3204 may run simultaneously with mixer 3202 to produce a different finished gum base.
- Both finished gum bases from mixers 3202, 3204 may simultaneously feed mixer 3206, for a set period of time, wherein a set of subsequent gum ingredients is processed with the finished gum bases to produce a finished gum.
- the finished gum bases from mixers 3202, 3204 are directed to mixer 3208 for a set period of time wherein a set of subsequent gum ingredients different than the set added to mixer 3206 is processed with the gum bases to produce a yet different finished gum.
- mixer 3202 may produce a compounded elastomer which feeds mixers 3206 and 3208 simultaneously wherein mixer 3206 and mixer 3208 may produce the same or different gum structures.
- mixer 3204 may produce a finished gum base with a set of subsequent gum ingredients, which is fed to mixer 3206 and mixer 3208 simultaneously in sequence with the effluent of mixer 3202, wherein mixers 3206, 3208 may produce the same or different gum structures.
- each mixer as being located in different plants, one or more or all mixers of system 3200 may be located in the same plant.
- System 3300 includes a continuous mixer 3302 and a batch mixer 3304 arranged in parallel with each other.
- System 3300 further includes a batch mixer 3306 arranged in series with and downstream of each of the parallel mixers 3302, 3304, and a continuous mixer 3308 arranged in series with and downstream of mixer 3306.
- effluents of the parallel mixers 3302, 3304 can be used, together or sequentially, as ingredients for a gum structure formed in mixer 3306, which is then used as an ingredient in mixer 3308.
- an effluent from a mixer may be recirculated within the system or an effluent of a mixer may be directed to another mixer arranged in parallel with that mixer to extend a mixing time of ingredients or to produce a different output.
- effluent of mixer 3308 may be recirculated as an ingredient of mixer 3306 or effluent of mixer 3302 may be fed as an ingredient to mixer 3304.
- mixer 3302 may be located in plant 3310, mixer 3304 may be located in plant 3312, and mixers 3306 and 3308 may be located in plant 3314.
- Mixer 3302 of plant 3310 and mixer 3304 of plant 3312 may produce a same gum base master batch GBMB. Such implementation may be advantageous, where plants 3310 and 3312 supply gum base master batch GBMB to multiple plants, plant 3314 being one of them, and plant 3314 can receive delivery from either plant 3310 or 3312, depending on the availability of supply in plants 3310, 3312.
- each of mixers 3302, 3304 can produce the same gum base master batch GBMB from a set of gum base ingredients GBIx consisting of 9.1% butyl rubber, 22.7% polyvinyl acetate, 11.4% polyisobutylene, 11.4% rosin esters, 11.4% waxes, 28.4% vegetable oils and 5.6% triacetin, all by weight percent relative to total weight of GBIx.
- GBIx gum base ingredients
- Production of GBMB in plants 3310 and 3312 can fluctuate for many different reasons such as raw ingredient availability in the area.
- operation of one of mixers 3302, 3304 may be shut down for maintenance or periodically according to market demand. Therefore, mixer 3306 may receive shipments from both plants 3310, 3312, or from one of the plants 3310, 3312, at any given time.
- mixer 3306 may process gum base master batch GBMB from mixers 3302 and/or 3304 with an additional set of gum base ingredients GBIy consisting of talc.
- a batch of mixer 3306 may include 88% by weight of GBMB and 12% by weight of talc, producing finished gum base FGB which is a formulation of Representative Gum Base 5 in Table 2.
- mixer 3308 effluent of mixer 3306, namely FGB, is fed to mixer 3308 wherein FGB is mixed with a set of subsequent gum ingredient SGIz to produce finished gum FG.
- mixer 3308 can process 30% FGB with 1% hydrogenated starch hydrolysates, 59% sorbitol, 1% glycerin, 5% lecithin, 3.8% flavor and 0.2% color, all by weight percentage. Feed rates of ingredients can be adjusted according to a desired output rate as described above for continuous mixers in other parallel mixing systems.
- each of mixers in system 3300 can process numerous different combinations of gum ingredients to output different effluents, simultaneously or sequentially.
- mixers 3302 and 3304 may output two different gum base master batches which are either simultaneously or sequentially fed to mixer 3306. That is, mixer 3306 may process each gum base master batch sequentially with different sets of additional gum base ingredients to sequentially produce two different finished gums, or mixer 3306 may process both gum base master batches simultaneously with or without a set of additional gum base ingredients to produce a finished gum.
- Mixers 3302 and 3304 may produce different gum structures than a gum base master batch, such as the same finished gum or two different finished gums, or the same gum base with a set of subsequent gum ingredients or two different gum bases with a set of subsequent gum ingredients, etc. According to effluents supplied by mixers 3302, 3304 and other gum ingredients added, effluent of mixer 3306 will vary. Similarly, effluent of 3308 will vary with the effluent supplied by mixer 3306 and other ingredients added.
- mixers of system 3300 may be located in one plant, or one or more mixers may be located in different plants.
Landscapes
- Engineering & Computer Science (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Confectionery (AREA)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08868714.0A EP2230927A4 (fr) | 2007-12-21 | 2008-12-19 | Systèmes de mélange de composants de gomme en parallèle et procédés associés |
Applications Claiming Priority (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US1601607P | 2007-12-21 | 2007-12-21 | |
US61/016,016 | 2007-12-21 | ||
US3662608P | 2008-03-14 | 2008-03-14 | |
US61/036,626 | 2008-03-14 | ||
US4576408P | 2008-04-17 | 2008-04-17 | |
US61/045,764 | 2008-04-17 | ||
US12/338,682 | 2008-12-18 | ||
US12/338,682 US20090162476A1 (en) | 2007-12-21 | 2008-12-18 | Parallel Gum Component Mixing Systems And Methods |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009086070A2 true WO2009086070A2 (fr) | 2009-07-09 |
Family
ID=40788944
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/087618 WO2009086066A2 (fr) | 2007-12-21 | 2008-12-19 | Systèmes de mélange de structures de gomme et méthodes associées |
PCT/US2008/087625 WO2009086070A2 (fr) | 2007-12-21 | 2008-12-19 | Systèmes de mélange de composants de gomme en parallèle et procédés associés |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2008/087618 WO2009086066A2 (fr) | 2007-12-21 | 2008-12-19 | Systèmes de mélange de structures de gomme et méthodes associées |
Country Status (3)
Country | Link |
---|---|
US (2) | US20090162476A1 (fr) |
EP (2) | EP2247190A4 (fr) |
WO (2) | WO2009086066A2 (fr) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8226401B2 (en) | 2009-01-12 | 2012-07-24 | Kraft Foods Global Brands Llc | Gum manufacturing system with loafing and conditioning features |
EP2683251B1 (fr) | 2011-03-11 | 2021-08-25 | Intercontinental Great Brands LLC | Procédé de fabrication de confiserie multicouche |
JP5912180B2 (ja) | 2011-07-21 | 2016-04-27 | インターコンチネンタル グレート ブランズ エルエルシー | チューインガムの形成および冷却のためのシステムおよび方法 |
EP2838373B1 (fr) * | 2012-04-20 | 2020-02-12 | Intercontinental Great Brands LLC | Système et procédé de fabrication de gomme à mâcher |
CN102731198A (zh) * | 2012-05-28 | 2012-10-17 | 徐州市芭田生态有限公司 | 一种高塔熔体造粒工艺生产有机-无机复混肥料的方法 |
ES2940236T3 (es) * | 2013-12-06 | 2023-05-04 | Intercontinental Great Brands Llc | Sistema y método para hender y/o cortar una goma de mascar |
US10334867B2 (en) | 2014-03-03 | 2019-07-02 | Intercontinental Great Brands Llc | Method for manufacturing a comestible |
EP3862281B1 (fr) | 2018-01-05 | 2024-03-27 | Intercontinental Great Brands LLC | Emballage d'un produit comestible comme un chewing-gum, sans conditionnement |
CN109170075A (zh) * | 2018-09-28 | 2019-01-11 | 湖北美雅食品有限公司 | 一种添加桂花的酥糖生产线 |
CN110589041B (zh) * | 2019-09-24 | 2024-07-26 | 上海上药新亚药业有限公司 | 一种交替式药品凝胶体配制方法与系统 |
CN113044597A (zh) * | 2021-04-13 | 2021-06-29 | 山东东宏管业股份有限公司 | 一种用于pvc粉料的供料系统及方法 |
Family Cites Families (143)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1879897A (en) * | 1928-05-09 | 1932-09-27 | Gernelle-Danloy Joseph Emile | Grinding and mixing apparatus |
US3215407A (en) * | 1960-12-19 | 1965-11-02 | Phillips Petroleum Co | Blending apparatus |
US3455755A (en) * | 1963-12-31 | 1969-07-15 | L A Drevfus Co | Method and apparatus for producing laminated slabs |
US3644169A (en) * | 1963-12-31 | 1972-02-22 | L A Dreyfus Co | Laminated slabs of chewing gum base |
US4136163A (en) * | 1971-02-04 | 1979-01-23 | Wilkinson Sword Limited | P-menthane carboxamides having a physiological cooling effect |
US3881708A (en) * | 1972-06-15 | 1975-05-06 | Usm Corp | Mixing extruders |
CA1027347A (fr) * | 1972-07-20 | 1978-03-07 | David G. Rowsell | Composes ayant un effet physiologique de refroidissement et compositions contenant du ehcm |
US4124339A (en) * | 1974-11-22 | 1978-11-07 | The Jimmy Dean Meat Company, Inc. | System for extruding and forming portion controlled frozen food products |
US3995064A (en) * | 1975-06-04 | 1976-11-30 | Life Savers, Inc. | Method and apparatus for forming chewing gum base and product |
US4187320A (en) * | 1978-05-01 | 1980-02-05 | Warner-Lambert Company | Process for preparing chewing gum base using solid elastomer |
FR2444080A1 (fr) * | 1978-12-11 | 1980-07-11 | Roquette Freres | Hydrolysat d'amidon hydrogene non cariogene pour la confiserie et procede de preparation de cet hydrolysat |
CH637308A5 (de) * | 1979-04-05 | 1983-07-29 | Alusuisse | Verfahren zur aufbereitung eines bei der herstellung von elektroden verwendeten mischguts. |
US4257355A (en) * | 1979-08-17 | 1981-03-24 | A. O. Smith Corporation | Cold water inlet tube |
US4370350A (en) * | 1980-04-28 | 1983-01-25 | Wm. Wrigley Jr. Company | Chewing gum method |
US4357355A (en) * | 1981-06-03 | 1982-11-02 | Warner-Lambert Company | Non-stick bubble gum base composition |
US4473299A (en) * | 1981-06-10 | 1984-09-25 | Raul Guibert | Gluten producing system |
US4490046A (en) * | 1981-06-10 | 1984-12-25 | Raul Guibert | Multi-stage automatic dough-producing system |
US4379169A (en) * | 1981-11-09 | 1983-04-05 | Nabisco Brands, Inc. | New gum base and chewing gum containing same |
JPS5888334A (ja) * | 1981-11-20 | 1983-05-26 | Takasago Corp | 3−l−メントキシプロパン−1、2−ジオ−ル |
WO1983003999A1 (fr) * | 1982-05-17 | 1983-11-24 | Max Gutknecht | Procede et presse a vis pour la reduction de volume de materiaux |
US4448736A (en) * | 1982-05-24 | 1984-05-15 | Standard Oil Company (Indiana) | Continuous in-line melt flow rate control system |
US4510271A (en) * | 1982-10-27 | 1985-04-09 | Exxon Research & Engineering Co. | Method of finishing thermoplastic granules |
US4459311A (en) * | 1983-01-03 | 1984-07-10 | Nabisco Brands, Inc. | Process for preparing gum base |
DE3335954A1 (de) * | 1983-10-04 | 1985-04-04 | Roland Dipl.-Kaufm. 7022 Leinfelden-Echterdingen Belz | Verfahren zur durchfuehrung von chemischen reaktionen, insbesondere zur herstellung von kunststoffen mit hilfe von extrudern und anlage hierzu |
US4671961A (en) * | 1984-05-18 | 1987-06-09 | Wm. Wrigley Jr. Company | Chewing gum compositions and methods of preparation |
US4929508A (en) * | 1984-10-05 | 1990-05-29 | Warner-Lambert Company | Novel drug delivery system for antitussives |
US4933183A (en) * | 1984-10-05 | 1990-06-12 | Warner-Lambert Company | Novel drug delivery system for mineral supplements |
US4935242A (en) * | 1984-10-05 | 1990-06-19 | Warner-Lambert Company | Novel drug delivery system for expectorants |
US4792495A (en) * | 1985-04-22 | 1988-12-20 | Seiko Epson Corporation | Fusible ink sheet |
US4929447A (en) * | 1986-01-07 | 1990-05-29 | Warner-Lambert Company | Encapsulation composition for use with chewing gum and edible products |
US4711784A (en) * | 1986-01-07 | 1987-12-08 | Warner-Lambert Company | Encapsulation composition for use with chewing gum and edible products |
US4692478A (en) * | 1986-03-14 | 1987-09-08 | Chemical Process Corporation | Process for preparation of resin and resin obtained |
ZA871658B (en) * | 1986-03-27 | 1987-08-28 | Warner-Lambert Company | Chewing gum and confectionery compositions containing a soy flavor enhancer |
US5110607A (en) * | 1986-05-20 | 1992-05-05 | Warner-Lambert Company | Chewing gum composition and method of making same |
JPS6356407A (ja) * | 1986-08-27 | 1988-03-11 | Bridgestone Corp | ゴムの混練方法 |
US5217735A (en) * | 1986-10-22 | 1993-06-08 | Wm. Wrigley Jr. Company | Method of making chewing gum with delayed release ingredients |
US4724151A (en) * | 1986-10-24 | 1988-02-09 | Warner-Lambert Company | Chewing gum compositions having prolonged breath-freshening |
US4872884A (en) * | 1986-12-10 | 1989-10-10 | Warner-Lambert Company | Reduced calorie chewing gum base and compositions containing the same |
US4915958A (en) * | 1986-12-10 | 1990-04-10 | Warner-Lambert Company | High-base gum composition with extended flavor release |
US4764020A (en) * | 1986-12-12 | 1988-08-16 | Masao Moriyama | Apparatus for mixing and extruding viscous liquids |
US4816265A (en) * | 1986-12-23 | 1989-03-28 | Warner-Lambert Company | Sweetener delivery systems containing polyvinyl acetate |
US4933190A (en) * | 1986-12-23 | 1990-06-12 | Warner-Lambert Co. | Multiple encapsulated sweetener delivery system |
US4981698A (en) * | 1986-12-23 | 1991-01-01 | Warner-Lambert Co. | Multiple encapsulated sweetener delivery system and method of preparation |
US4806364A (en) * | 1987-04-22 | 1989-02-21 | Wm. Wrigley Jr. Company | Method of making chewing gum |
DE3738700A1 (de) * | 1987-11-14 | 1989-06-01 | Werner & Pfleiderer | Doppelschneckenextruder |
US5125819A (en) * | 1987-11-24 | 1992-06-30 | Warner-Lambert Company | Apparatus for making center-filled chewing gum |
US4906102A (en) * | 1988-04-08 | 1990-03-06 | Reifenhauser Gmbh & Co. Maschinenfabrik | Apparatus for mixing thermoplastified synthetic resins |
US5110608A (en) * | 1988-12-29 | 1992-05-05 | Warner-Lambert Company | Chewing gums having longer lasting sweetness |
US4933189A (en) * | 1988-12-29 | 1990-06-12 | Warner-Lambert Company | Chewing gum having longer lasting sweetness |
US4997659A (en) * | 1989-03-28 | 1991-03-05 | The Wm. Wrigley Jr. Company | Alitame stability in chewing gum by encapsulation |
JP2652242B2 (ja) * | 1989-04-28 | 1997-09-10 | 横浜ゴム株式会社 | 混練材料の供給方法及びその装置 |
US5085872A (en) * | 1990-08-16 | 1992-02-04 | Wm. Wrigley Jr. Company | Method of manufacturing a chewing gum base |
US5192562A (en) * | 1990-08-16 | 1993-03-09 | Wm. Wrigley Jr. Company | Method of manufacturing a chewing gum |
US5128155A (en) * | 1990-12-20 | 1992-07-07 | Wm. Wrigley Jr. Company | Flavor releasing structures for chewing gum |
US5310955A (en) * | 1991-01-18 | 1994-05-10 | The Dow Chemical Company | Vertical continuous reactor and process for liquid epoxy resin |
US5126151A (en) * | 1991-01-24 | 1992-06-30 | Warner-Lambert Company | Encapsulation matrix |
US5223282A (en) * | 1991-02-01 | 1993-06-29 | Wm. Wrigley Jr. Company | Methods of producing chewing gum using molten sorbitol and gum produced thereby |
DE4110135A1 (de) * | 1991-03-27 | 1992-10-01 | Windmoeller & Hoelscher | Verfahren und vorrichtung zur bestimmung der von einem extruder aus einem aufgabebehaelter ueber die zeit abgezogenen menge |
DE4110973A1 (de) * | 1991-04-05 | 1992-10-08 | Haarmann & Reimer Gmbh | Mittel mit physiologischem kuehleffekt und fuer diese mittel geeignete wirksame verbindungen |
US5679389A (en) * | 1991-07-12 | 1997-10-21 | Warner-Lambert Company | Chewing gum compositions having increased flavor and sweetness and methods for preparing same |
US5227154A (en) * | 1991-08-22 | 1993-07-13 | The University Of Melbourne | Phosphopeptides for the treatment of dental calculus |
US5300305A (en) * | 1991-09-12 | 1994-04-05 | The Procter & Gamble Company | Breath protection microcapsules |
US5192561A (en) * | 1991-09-19 | 1993-03-09 | Wm. Wrigley Jr. Company | Aspartame stability in chewing gum using an acid gelatin system |
US5164210A (en) * | 1991-10-08 | 1992-11-17 | Wm. Wrigley Jr. Company | Zein/shellac encapsulation of high intensity sweeteners in chewing gum |
US5378131A (en) * | 1993-02-18 | 1995-01-03 | The Wm. Wrigley Jr. Company | Chewing gum with dental health benefits employing calcium glycerophosphate |
US5436013A (en) * | 1993-03-02 | 1995-07-25 | Wm. Wrigley Jr. Company | Process for manufacturing wax-free chewing gums with fast set-up times |
US7112345B1 (en) * | 1993-04-07 | 2006-09-26 | Wm. Wrigley Jr. Company | Multi-Phase sheeted chewing gum and method and apparatus for making |
US5324530A (en) * | 1993-05-24 | 1994-06-28 | Nabisco, Inc. | Apparatus and method for making extruded chewing gum |
US5283021A (en) * | 1993-06-14 | 1994-02-01 | Chi Mei Corporation | Process for removing the solvent from an elastomeric polymer solution |
US5405623A (en) * | 1993-09-22 | 1995-04-11 | Wm. Wrigley Jr. Company | Chewing gum compositions and methods for manufacturing same |
US5397580A (en) * | 1993-10-22 | 1995-03-14 | Wm. Wrigley Jr. Company | Continuous gum base manufacture using sequential mixers |
US6010723A (en) * | 1993-09-24 | 2000-01-04 | The Wm. Wrigley Jr. Company | Method for manufacturing gum base |
US5773053A (en) * | 1993-09-24 | 1998-06-30 | Wm. Wrigley Jr. Company | Chewing gum base manufacturing process using plurality of softening agents inlets |
US6004589A (en) * | 1993-09-24 | 1999-12-21 | Wm. Wrigley Jr. Company | Chewing gum base manufacturing process using plurality of filler feed inlet locations |
US5486366A (en) * | 1993-09-24 | 1996-01-23 | Wm. Wrigley Jr. Company | Continuous chewing gum base manufacturing process using a mixing-restriction element |
US5419919A (en) * | 1993-10-22 | 1995-05-30 | Wm. Wrigley Jr. Company | Continuous gum base manufacture using paddle mixing |
US6238710B1 (en) * | 1993-09-24 | 2001-05-29 | Wm. Wrigley, Jr. Company | Method for continuous gum base manufacture |
US6086925A (en) * | 1993-09-24 | 2000-07-11 | Wm. Wrigley Jr. Company | Chewing gum base manufacturing process using plurality of lubricating agents feed inlets |
US5637334A (en) * | 1993-09-30 | 1997-06-10 | Wm. Wrigley Jr. Company | Chewing gum containing maltitol |
DE69517836T2 (de) * | 1994-03-18 | 2001-03-01 | Ajinomoto Co., Inc. | Proteinhaltiges Mittel zur Verbesserung der Geschmacksqualität von Lebensmitteln |
US5429827A (en) * | 1994-04-12 | 1995-07-04 | Wm. Wrigley Jr. Company | Method of making improved gum base for fruit-flavored chewing gum |
US5425962A (en) * | 1994-05-13 | 1995-06-20 | Wm. Wrigley Jr. Company | Method for refining mint oils and chewing gum made from same |
US6030647A (en) * | 1994-09-13 | 2000-02-29 | Wm. Wrigley Jr. Company | Continuous chewing gum manufacturing process for gum with controlled flavor release |
CA2199604C (fr) * | 1994-09-13 | 2002-03-05 | Donald J. Townsend | Production de gomme a macher en continu a partir d'un concentre d'une base pour gomme a macher |
AU713465B2 (en) * | 1994-09-13 | 1999-12-02 | Wm. Wrigley Jr. Company | Method for continuous gum base manufacturing |
US5650232A (en) * | 1994-10-07 | 1997-07-22 | Warner-Lambert Company | Method for making seamless capsules |
US5474787A (en) * | 1994-10-21 | 1995-12-12 | The Wm. Wrigley Jr. Company | Chewing gum containing a lecithin/glycerol triacetate blend |
US5698181A (en) * | 1994-12-09 | 1997-12-16 | Warner-Lambert Company | Breath-freshening edible compositions comprising menthol and an N-substituted-P-menthane carboxamide and methods for preparing same |
US5601858A (en) * | 1994-12-29 | 1997-02-11 | Warner-Lambert Company | Non-stick chewing gum |
US5492562A (en) * | 1995-02-07 | 1996-02-20 | Pettinato; Dana M. | Low freezing point roofing shingle containing a chloride salt |
DE69520935T2 (de) * | 1995-03-13 | 2001-09-20 | Wm. Wrigley Jr. Co., Chicago | Kontinuierliche Herstellung von Kaugummi-Grundmasse mittels seriell arbeitender Mischer |
US5595757A (en) * | 1995-03-29 | 1997-01-21 | Warner-Lambert Company | Seamless capsules |
US5567450A (en) * | 1995-06-07 | 1996-10-22 | Wm. Wrigley Jr. Company | Gum base manufacturing method |
US5976581A (en) * | 1995-09-12 | 1999-11-02 | Wm. Wrigley Jr. Company | Continuous chewing gum manufacturing process using rework gum |
US6017565A (en) * | 1996-02-21 | 2000-01-25 | Wm. Wrigley Jr. Company | Method for automated continuous production of chewing gum |
US5827549A (en) * | 1996-02-21 | 1998-10-27 | Wm. Wrigley, Jr. Company | Process control system for automated continuous production of chewing gum |
US5756020A (en) * | 1996-04-09 | 1998-05-26 | E. I. Du Pont De Nemours And Company | Method for producing solution dyed articles from thermoplastic polymers |
US5792494A (en) * | 1996-08-01 | 1998-08-11 | L. A. Dreyfus Co. | Gum base manufacturing method using elastomer emulsions |
US5837302A (en) * | 1996-10-03 | 1998-11-17 | Warner-Lambert Company | Polyvinyl acetate process for chewing gum |
US5853243A (en) * | 1996-10-03 | 1998-12-29 | Warner-Lambert Company | High molecular weight elastomer processing system for chewing gum |
US5756133A (en) * | 1996-10-03 | 1998-05-26 | Warner-Lambert Company | Continuous gum base processing with cooling towers |
US7025999B2 (en) * | 2001-05-11 | 2006-04-11 | Wm. Wrigley Jr. Company | Chewing gum having prolonged sensory benefits |
US6080432A (en) * | 1996-12-23 | 2000-06-27 | Wm. Wrigley Jr. Company | Chewing gum composition containing sodium glycinate and method of making a chewing gum product therefrom |
US6017566A (en) * | 1997-10-20 | 2000-01-25 | Wm. Wrigley Jr. Company | Gum base and chewing gum containing edible polyesters and method for manufacture |
US6190706B1 (en) * | 1997-12-23 | 2001-02-20 | Wm. Wrigley Jr. Company | Chewing gum and gum bases having reduced adhesion to environmental surfaces and method for making |
US6630182B1 (en) * | 1997-12-30 | 2003-10-07 | Cadbury Adams Usa Llc | System for continuously producing gum with improved texture and flavor release |
US6692778B2 (en) * | 1998-06-05 | 2004-02-17 | Wm. Wrigley Jr. Company | Method of controlling release of N-substituted derivatives of aspartame in chewing gum |
US6235318B1 (en) * | 1999-01-21 | 2001-05-22 | Charles M. Lombardy, Jr. | Effervescent chewing gum |
US6200608B1 (en) * | 1999-03-19 | 2001-03-13 | L. A. Dreyfus Co. | Process of producing chewing gum base in particle form and product thereof |
US6846500B1 (en) * | 1999-03-25 | 2005-01-25 | Cadbury Adams Usa Llc | Oral care chewing gums and method of use |
AR024361A1 (es) * | 1999-06-15 | 2002-10-02 | Dow Chemical Co | Proceso y aparato para preparar una composicion utilizando un reactor continuo y mezclador en serie |
US6838431B2 (en) * | 1999-07-27 | 2005-01-04 | Pacific Health Laboratories, Inc. | Nutritional intervention composition containing a source of proteinase inhibitor extending post meal satiety |
US6250480B1 (en) * | 1999-07-29 | 2001-06-26 | Justin A. McGuinness | Handle supporting fishing rod rack |
US6803061B1 (en) * | 1999-08-04 | 2004-10-12 | Wm. Wrigley Jr. Company | Ingestible chewing gum for animals |
WO2001010237A1 (fr) * | 1999-08-05 | 2001-02-15 | Wm. Wrigley Jr. Company | Produits de confiserie presentant une duree de conservation amelioree et procedes de fabrication associes |
US6365203B2 (en) * | 1999-08-16 | 2002-04-02 | Warner-Lambert Company | Continuous coating of chewing gum materials |
US6582738B2 (en) * | 1999-09-13 | 2003-06-24 | Deseret Laboratories, Inc. | Process for preparing chewing gum containing a nutritional supplement |
US6705757B2 (en) * | 1999-11-12 | 2004-03-16 | Alkermes Controlled Therapeutics, Inc. Ii | Method and apparatus for preparing microparticles using in-line solvent extraction |
US6974597B2 (en) * | 1999-11-29 | 2005-12-13 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing salty taste, salty taste enhancer, salty taste seasoning agent and salty taste-enhanced foods |
US6350480B1 (en) * | 1999-12-30 | 2002-02-26 | Wm. Wrigley Jr. Company | Chewing gum product including a hydrophilic gum base and method of producing |
US6207638B1 (en) * | 2000-02-23 | 2001-03-27 | Pacifichealth Laboratories, Inc. | Nutritional intervention composition for enhancing and extending satiety |
US6471945B2 (en) * | 2000-03-10 | 2002-10-29 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
US6485739B2 (en) * | 2000-03-10 | 2002-11-26 | Warner-Lambert Company | Stain removing chewing gum and confectionery compositions, and methods of making and using the same |
US6479071B2 (en) * | 2000-03-10 | 2002-11-12 | Warner-Lambert Company | Chewing gum and confectionery compositions with encapsulated stain removing agent compositions, and methods of making and using the same |
NL1015010C2 (nl) * | 2000-04-25 | 2001-10-26 | Dsm Nv | Werkwijze voor het vormgeven vanuit de smelt voor een polymeersamenstelling. |
US7115288B2 (en) * | 2000-06-09 | 2006-10-03 | Wm. Wrigley Jr. Company | Method for making coated chewing gum products with a coating including an aldehyde flavor and a dipeptide sweetener |
BR0112176A (pt) * | 2000-06-15 | 2003-10-07 | Dow Global Technologies Inc | Processo e aparelhagem para preparar polìmeros, utilizando um dispositivo ultra-sÈnico de corrente lateral para monitorar e controlar as propriedades do polìmero |
DE60132786T2 (de) * | 2000-09-12 | 2009-02-05 | Wm. Wrigley Jr. Comp., Chicago | Kaugummiformulierungen enthaltend verkapseltes aspartam sowie natriumpyrophosphat |
US6558690B2 (en) * | 2000-12-15 | 2003-05-06 | Pacific Health Laboratories, Inc. | Nutritional composition for improving the efficacy of a lipase inhibitor |
US6551643B2 (en) * | 2001-05-22 | 2003-04-22 | Wm. Wrigley Jr. Company | Process and apparatus for producing miniature gum ball centers using an underwater pelletizer |
DE10150627A1 (de) * | 2001-10-12 | 2003-05-15 | Gneuss Kunststofftechnik Gmbh | Extruder zur Gewinnung von Kunststoff-Schmelzen |
US20030215417A1 (en) * | 2002-04-18 | 2003-11-20 | The Procter & Gamble Company | Malodor-controlling compositions comprising odor control agents and microcapsules containing an active material |
CN1723011A (zh) * | 2002-06-25 | 2006-01-18 | Wm·雷格利Jr·公司 | 含有厚朴提取物的口气清新和口腔清洁产品 |
WO2004008872A2 (fr) * | 2002-07-23 | 2004-01-29 | Wm. Wrigley Jr. Company | Aromes encapsules et gomme a macher contenant ces aromes |
US6685916B1 (en) * | 2002-10-31 | 2004-02-03 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces, and methods of making and using the same |
US7445769B2 (en) * | 2002-10-31 | 2008-11-04 | Cadbury Adams Usa Llc | Compositions for removing stains from dental surfaces and methods of making and using the same |
US7581872B2 (en) * | 2003-04-30 | 2009-09-01 | Serva Corporation | Gel mixing system |
US7390518B2 (en) * | 2003-07-11 | 2008-06-24 | Cadbury Adams Usa, Llc | Stain removing chewing gum composition |
US20050112236A1 (en) * | 2003-11-21 | 2005-05-26 | Navroz Boghani | Delivery system for active components as part of an edible composition having preselected tensile strength |
JP4487598B2 (ja) * | 2004-03-04 | 2010-06-23 | 株式会社日立プラントテクノロジー | 重合方法及び重合装置 |
US20060078508A1 (en) * | 2004-10-13 | 2006-04-13 | Cadbury Adams Usa Llc | Effervescent pressed gum tablet compositions |
US20090238027A1 (en) * | 2004-10-19 | 2009-09-24 | The Yokohama Rubber Co., Ltd. | Apparatus for and Method of Kneading Rubber Material |
EP2003983B1 (fr) * | 2006-03-31 | 2013-01-23 | Wm. Wrigley Jr. Company | Arômes encapsulés longue durée et gomme à mâcher dans laquelle sont utilisés ces arômes encapsulés longue durée |
-
2008
- 2008-12-18 US US12/338,682 patent/US20090162476A1/en not_active Abandoned
- 2008-12-18 US US12/338,428 patent/US20090162475A1/en not_active Abandoned
- 2008-12-19 WO PCT/US2008/087618 patent/WO2009086066A2/fr active Application Filing
- 2008-12-19 WO PCT/US2008/087625 patent/WO2009086070A2/fr active Application Filing
- 2008-12-19 EP EP08866890.0A patent/EP2247190A4/fr not_active Withdrawn
- 2008-12-19 EP EP08868714.0A patent/EP2230927A4/fr not_active Withdrawn
Non-Patent Citations (1)
Title |
---|
See references of EP2230927A1 * |
Also Published As
Publication number | Publication date |
---|---|
EP2247190A4 (fr) | 2014-02-19 |
US20090162476A1 (en) | 2009-06-25 |
EP2230927A4 (fr) | 2014-02-12 |
US20090162475A1 (en) | 2009-06-25 |
EP2247190A1 (fr) | 2010-11-10 |
WO2009086066A2 (fr) | 2009-07-09 |
EP2230927A1 (fr) | 2010-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US20190230954A1 (en) | System and method of forming and sizing chewing gum and/or altering temperature of chewing gum | |
EP2838373B1 (fr) | Système et procédé de fabrication de gomme à mâcher | |
US20090162476A1 (en) | Parallel Gum Component Mixing Systems And Methods | |
EP2734055B1 (fr) | Formage de gomme à mâcher avancé | |
WO2008030274A1 (fr) | Compositions de sucrerie et de chewing gum avec fourrage contenant des particules de saccharide en suspension | |
EP2897468B1 (fr) | Fabrication de gomme élaborée | |
EP1895856A2 (fr) | Composition de confiserie contenant un composant elastomere, un composant saccharide cuit et un ingredient fonctionnel | |
WO2012125397A2 (fr) | Système et procédé de fabrication de confiserie multicouche | |
AU2008259951B2 (en) | Center-fill gum compositions incorporating triacetin | |
WO2006127277A2 (fr) | Composition de gomme a macher a fourrage liquide | |
EP2734053B1 (fr) | Formage de gomme avancé | |
WO2015054576A2 (fr) | Système et procédé de fabrication de compositions d'encapsulation | |
US20160106120A1 (en) | A system and method for forming a chewing gum product with at least one inclusion |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
121 | Ep: the epo has been informed by wipo that ep was designated in this application |
Ref document number: 08868714 Country of ref document: EP Kind code of ref document: A2 |
|
NENP | Non-entry into the national phase |
Ref country code: DE |
|
REEP | Request for entry into the european phase |
Ref document number: 2008868714 Country of ref document: EP |
|
WWE | Wipo information: entry into national phase |
Ref document number: 2008868714 Country of ref document: EP |