WO2009066737A1 - 送液チップおよび分析方法 - Google Patents

送液チップおよび分析方法 Download PDF

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Publication number
WO2009066737A1
WO2009066737A1 PCT/JP2008/071148 JP2008071148W WO2009066737A1 WO 2009066737 A1 WO2009066737 A1 WO 2009066737A1 JP 2008071148 W JP2008071148 W JP 2008071148W WO 2009066737 A1 WO2009066737 A1 WO 2009066737A1
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Prior art keywords
liquid
holding
feeding
baths
chip
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PCT/JP2008/071148
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English (en)
French (fr)
Inventor
Kentaro Ishii
Masashi Higasa
Shingo Hiramatsu
Original Assignee
Toray Industries, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Toray Industries, Inc. filed Critical Toray Industries, Inc.
Priority to KR1020107010430A priority Critical patent/KR101530577B1/ko
Priority to US12/743,248 priority patent/US8821813B2/en
Priority to BRPI0818988 priority patent/BRPI0818988A2/pt
Priority to JP2008557371A priority patent/JP5636629B2/ja
Priority to CN200880125169.2A priority patent/CN101918849B/zh
Priority to EP08851388.2A priority patent/EP2214027B1/en
Priority to CA2706402A priority patent/CA2706402C/en
Publication of WO2009066737A1 publication Critical patent/WO2009066737A1/ja

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00—Sampling; Preparing specimens for investigation
    • G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38—Diluting, dispersing or mixing samples
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/487—Physical analysis of biological material of liquid biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/08—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a stream of discrete samples flowing along a tube system, e.g. flow injection analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1009—Characterised by arrangements for controlling the aspiration or dispense of liquids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0621—Control of the sequence of chambers filled or emptied
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/087—Multiple sequential chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0409—Moving fluids with specific forces or mechanical means specific forces centrifugal forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0457—Moving fluids with specific forces or mechanical means specific forces passive flow or gravitation
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00029—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor provided with flat sample substrates, e.g. slides
    • G01N2035/00099—Characterised by type of test elements
    • G01N2035/00158—Elements containing microarrays, i.e. "biochip"
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00495—Centrifuges
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/20—Oxygen containing
    • Y10T436/206664—Ozone or peroxide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Centrifugal Separators (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Sampling And Sample Adjustment (AREA)

Abstract

　回転軸の周りにチップを回転させることにより遠心力および重力の作用を利用して液体を送液するチップであって、チップ回転停止時に液体を導入可能な第１の貯液槽（１－１）と、送液ユニット（Ｕ－１、Ｕ－２、Ｕ－３）が、それぞれ第１の保持槽（１０－１、２０－１、３０－１）と、第１の保持槽の重力方向に位置する第２の保持槽（１０－２、２０－２）、３０－２）と、第１の保持槽から重力方向に延伸し、第１の保持槽と第２の保持槽とを連通する流路Ｂ（Ｂ－１、Ｂ－２、Ｂ－３）からなり、第１段目の第１の保持槽が、第１の貯液槽から外周側に延伸する流路Ａ（Ａ－１）と接続されていて、互いに隣接して多段に配置されている、２以上の送液ユニットとを含み、隣接する送液ユニット同士が、上段の送液ユニットの第２の保持槽から回転の外周側に延伸し、下段の送液ユニットの第１の保持槽に連通する流路Ｃ（Ｃ－１、Ｃ－２）により連結される、送液チップ。
PCT/JP2008/071148 2007-11-20 2008-11-20 送液チップおよび分析方法 WO2009066737A1 (ja)

Priority Applications (7)

Application Number Priority Date Filing Date Title
KR1020107010430A KR101530577B1 (ko) 2007-11-20 2008-11-20 송액 칩 및 분석 방법
US12/743,248 US8821813B2 (en) 2007-11-20 2008-11-20 Liquid-feeding chip and analysis method
BRPI0818988 BRPI0818988A2 (pt) 2007-11-20 2008-11-20 "chip de alimentação líquida e métodos de análise e de alimentação de líquidos"
JP2008557371A JP5636629B2 (ja) 2007-11-20 2008-11-20 送液チップおよび分析方法
CN200880125169.2A CN101918849B (zh) 2007-11-20 2008-11-20 送液片和分析方法
EP08851388.2A EP2214027B1 (en) 2007-11-20 2008-11-20 Analyzing method in liquid-feeding chip
CA2706402A CA2706402C (en) 2007-11-20 2008-11-20 Liquid-feeding chip and analysis method

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-300445 2007-11-20
JP2007300445 2007-11-20
JP2008-165644 2008-06-25
JP2008165644 2008-06-25

Publications (1)

Publication Number Publication Date
WO2009066737A1 true WO2009066737A1 (ja) 2009-05-28

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ID=40667559

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Country Status (8)

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US (1) US8821813B2 (ja)
EP (1) EP2214027B1 (ja)
JP (1) JP5636629B2 (ja)
KR (1) KR101530577B1 (ja)
CN (1) CN101918849B (ja)
BR (1) BRPI0818988A2 (ja)
CA (1) CA2706402C (ja)
WO (1) WO2009066737A1 (ja)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011027421A (ja) * 2009-07-21 2011-02-10 Toray Ind Inc 分析チップおよび検体の分析方法
JP2011062197A (ja) * 2010-09-06 2011-03-31 Seiko Epson Corp 生体試料定量方法
JP2011062119A (ja) * 2009-09-16 2011-03-31 Seiko Epson Corp 生体試料定量用チップ
JP2013057524A (ja) * 2011-09-07 2013-03-28 Brother Ind Ltd 検査システム、及び検査方法
WO2013046835A1 (ja) * 2011-09-30 2013-04-04 ブラザー工業株式会社 検査対象受体
WO2013046818A1 (ja) * 2011-09-30 2013-04-04 ブラザー工業株式会社 検査装置、検査対象受体、および検査システム
US9352321B2 (en) 2010-11-17 2016-05-31 Seiko Epson Corporation Thermal cycler and thermal cycling method
JP2020071233A (ja) * 2018-10-31 2020-05-07 天亮醫療器材股▲ふん▼有限公司ＳＫＹＬＡ Ｃｏｒｐｏｒａｔｉｏｎ 検出カートリッジ、検出方法及び検出装置

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US9700888B1 (en) * 2016-04-13 2017-07-11 Ipmd Inc. Point of care medical device for detecting infectious diseases
GB201806931D0 (en) * 2018-04-27 2018-06-13 Radisens Diagnostics Ltd An improved point-of-care diagnostic assay cartridge
CN109374875A (zh) * 2018-11-20 2019-02-22 中国科学院生物物理研究所 低噪恒温重力灌流膜片钳装置
EP3911948A2 (en) * 2019-01-15 2021-11-24 Precision Planting LLC Soil analysis compositions and methods
CN112033953B (zh) * 2019-06-03 2024-04-19 利多(香港)有限公司 一种微流控芯片及应用

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JPS6425058A (en) * 1987-07-01 1989-01-27 Miles Inc Method for separation, weighing, dilution and distribution of liquid, assembly therefor and system for chemical analysis
WO2004074846A1 (ja) * 2003-02-19 2004-09-02 Japan Science And Technology Agency 血液分析装置及び血液分析方法
JP2006121935A (ja) 2004-10-27 2006-05-18 Konica Minolta Medical & Graphic Inc 前処理手段および廃液貯留部を有する生体物質検査用マイクロリアクタ
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WO2006106608A1 (ja) * 2005-04-04 2006-10-12 Matsushita Electric Industrial Co., Ltd. 液体均一化装置およびそれを用いた分析装置
JP2007198949A (ja) * 2006-01-27 2007-08-09 Matsushita Electric Ind Co Ltd 分析用ディスク、及び分析装置

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011027421A (ja) * 2009-07-21 2011-02-10 Toray Ind Inc 分析チップおよび検体の分析方法
JP2011062119A (ja) * 2009-09-16 2011-03-31 Seiko Epson Corp 生体試料定量用チップ
JP2011062197A (ja) * 2010-09-06 2011-03-31 Seiko Epson Corp 生体試料定量方法
US9352321B2 (en) 2010-11-17 2016-05-31 Seiko Epson Corporation Thermal cycler and thermal cycling method
JP2013057524A (ja) * 2011-09-07 2013-03-28 Brother Ind Ltd 検査システム、及び検査方法
WO2013046835A1 (ja) * 2011-09-30 2013-04-04 ブラザー工業株式会社 検査対象受体
WO2013046818A1 (ja) * 2011-09-30 2013-04-04 ブラザー工業株式会社 検査装置、検査対象受体、および検査システム
JP2013079812A (ja) * 2011-09-30 2013-05-02 Brother Ind Ltd 検査対象受体
JP2013079818A (ja) * 2011-09-30 2013-05-02 Brother Ind Ltd 検査装置、検査対象受体、および検査システム
US9199235B2 (en) 2011-09-30 2015-12-01 Brother Kogyo Kabushiki Kaisha Test chip
JP2020071233A (ja) * 2018-10-31 2020-05-07 天亮醫療器材股▲ふん▼有限公司ＳＫＹＬＡ Ｃｏｒｐｏｒａｔｉｏｎ 検出カートリッジ、検出方法及び検出装置
US11366083B2 (en) * 2018-10-31 2022-06-21 Skyla Corporation Detection cartridge, detection method, and detection device

Also Published As

Publication number Publication date
US8821813B2 (en) 2014-09-02
KR20100091971A (ko) 2010-08-19
CA2706402C (en) 2016-05-03
CN101918849B (zh) 2014-02-12
US20100255483A1 (en) 2010-10-07
CA2706402A1 (en) 2009-05-28
JPWO2009066737A1 (ja) 2011-04-07
BRPI0818988A2 (pt) 2015-05-05
CN101918849A (zh) 2010-12-15
KR101530577B1 (ko) 2015-06-22
EP2214027A1 (en) 2010-08-04
EP2214027B1 (en) 2019-03-06
EP2214027A4 (en) 2015-06-03
JP5636629B2 (ja) 2014-12-10

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