WO2009066642A1 - トリアゾール骨格を有する光応答性塩基 - Google Patents

トリアゾール骨格を有する光応答性塩基 Download PDF

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Publication number
WO2009066642A1
WO2009066642A1 PCT/JP2008/070884 JP2008070884W WO2009066642A1 WO 2009066642 A1 WO2009066642 A1 WO 2009066642A1 JP 2008070884 W JP2008070884 W JP 2008070884W WO 2009066642 A1 WO2009066642 A1 WO 2009066642A1
Authority
WO
WIPO (PCT)
Prior art keywords
nucleic acid
photolinker
formulae
producing
triazole skeleton
Prior art date
Application number
PCT/JP2008/070884
Other languages
English (en)
French (fr)
Inventor
Kenzou Fujimoto
Takehiro Ami
Chifumi Nagata
Akio Yamane
Original Assignee
Toppan Printing Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Toppan Printing Co., Ltd. filed Critical Toppan Printing Co., Ltd.
Publication of WO2009066642A1 publication Critical patent/WO2009066642A1/ja
Priority to US12/780,735 priority Critical patent/US20100298530A1/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

【課題】 従来よりも短時間で核酸を連結可能であり、用途に応じた修飾が簡単にできる光連結性の化合物及び光連結剤、該光連結剤の製造方法を提供すること。 【解決手段】 塩基部分として式Ｉ、式ＩＩＩ、式ＩＶ、又は式Ｖで表される基を有する核酸類、該核酸類からなる光連結剤、及び、塩基部分として式ＶＩ、式ＶＩＩ、式ＶＩＩＩ、又は式ＩＸで表される基を有する核酸類と、式Ｘで表される芳香族アジ化物とを反応させて核酸類を製造する方法。
PCT/JP2008/070884 2007-11-19 2008-11-17 トリアゾール骨格を有する光応答性塩基 WO2009066642A1 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US12/780,735 US20100298530A1 (en) 2007-11-19 2010-05-14 Photoresponsive Base Having Triazole Skeleton

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2007299901A JP5393021B2 (ja) 2007-11-19 2007-11-19 トリアゾール骨格を有する光応答性塩基
JP2007-299901 2007-11-19

Related Child Applications (1)

Application Number Title Priority Date Filing Date
US12/780,735 Continuation US20100298530A1 (en) 2007-11-19 2010-05-14 Photoresponsive Base Having Triazole Skeleton

Publications (1)

Publication Number Publication Date
WO2009066642A1 true WO2009066642A1 (ja) 2009-05-28

Family

ID=40667464

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/070884 WO2009066642A1 (ja) 2007-11-19 2008-11-17 トリアゾール骨格を有する光応答性塩基

Country Status (3)

Country Link
US (1) US20100298530A1 (ja)
JP (1) JP5393021B2 (ja)
WO (1) WO2009066642A1 (ja)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5582557B2 (ja) * 2008-09-05 2014-09-03 独立行政法人理化学研究所 ピリミジンヌクレオシド化合物およびその利用
JP5633133B2 (ja) * 2009-09-30 2014-12-03 凸版印刷株式会社 遺伝子解析装置
WO2014112199A1 (ja) 2013-01-17 2014-07-24 株式会社日立ハイテクノロジーズ 生体分子計測装置
WO2018047909A1 (ja) * 2016-09-08 2018-03-15 国立大学法人北海道大学 プリンヌクレオシド誘導体、ポリヌクレオチド及びｒｎａ
EP3792271A1 (en) 2019-09-13 2021-03-17 Aurobindo Pharma Limited A process for the preparation of brivudine
US11755922B2 (en) * 2019-10-04 2023-09-12 The Board Of Trustees Of The University Of Illinois On-chip nanoscale storage system using chimeric DNA

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4825520A (ja) * 1971-08-02 1973-04-03
JPS63157145A (ja) * 1986-12-22 1988-06-30 Nippon Telegr & Teleph Corp <Ntt> 感光性樹脂組成物
JP2001348398A (ja) * 2000-03-10 2001-12-18 Japan Science & Technology Corp ５−ピリミジン含有核酸、それを用いた可逆的連結方法
JP2002080840A (ja) * 2000-09-06 2002-03-22 National Institute Of Advanced Industrial & Technology 発光材料及び新規フラーレン誘導体
JP2002179696A (ja) * 2000-12-15 2002-06-26 Japan Science & Technology Corp 光連結性ヌクレオシド含有ｄｎａを用いて塩基を点変異する方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2006076905A (ja) * 2004-09-08 2006-03-23 Univ Nihon 光反応性核酸及び可逆的核酸光連結又は開裂方法

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS4825520A (ja) * 1971-08-02 1973-04-03
JPS63157145A (ja) * 1986-12-22 1988-06-30 Nippon Telegr & Teleph Corp <Ntt> 感光性樹脂組成物
JP2001348398A (ja) * 2000-03-10 2001-12-18 Japan Science & Technology Corp ５−ピリミジン含有核酸、それを用いた可逆的連結方法
JP2002080840A (ja) * 2000-09-06 2002-03-22 National Institute Of Advanced Industrial & Technology 発光材料及び新規フラーレン誘導体
JP2002179696A (ja) * 2000-12-15 2002-06-26 Japan Science & Technology Corp 光連結性ヌクレオシド含有ｄｎａを用いて塩基を点変異する方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
ROBINS, M.J. ET AL.: "Nucleic Acid Related Compounds. 39. Efficient Conversion of 5-Iodo to 5-Alkynyl and Derived 5-Substituted Uracil Bases and Nucleosides", J. ORG. CHEM., vol. 48, no. 11, 1983, pages 1854 - 1862 *

Also Published As

Publication number Publication date
JP2009126789A (ja) 2009-06-11
JP5393021B2 (ja) 2014-01-22
US20100298530A1 (en) 2010-11-25

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