WO2009054026A1 - 質量分析装置 - Google Patents

質量分析装置 Download PDF

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Publication number
WO2009054026A1
WO2009054026A1 PCT/JP2007/001156 JP2007001156W WO2009054026A1 WO 2009054026 A1 WO2009054026 A1 WO 2009054026A1 JP 2007001156 W JP2007001156 W JP 2007001156W WO 2009054026 A1 WO2009054026 A1 WO 2009054026A1
Authority
WO
WIPO (PCT)
Prior art keywords
ion
mass
metabolite
analysis
peak
Prior art date
Application number
PCT/JP2007/001156
Other languages
English (en)
French (fr)
Inventor
Shinichi Yamaguchi
Original Assignee
Shimadzu Corporation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shimadzu Corporation filed Critical Shimadzu Corporation
Priority to EP07827935.3A priority Critical patent/EP2208991B1/en
Priority to JP2009537775A priority patent/JP4941562B2/ja
Priority to US12/739,335 priority patent/US9672330B2/en
Priority to PCT/JP2007/001156 priority patent/WO2009054026A1/ja
Publication of WO2009054026A1 publication Critical patent/WO2009054026A1/ja
Priority to US13/946,874 priority patent/US9601322B2/en

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Classifications

    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16C—COMPUTATIONAL CHEMISTRY; CHEMOINFORMATICS; COMPUTATIONAL MATERIALS SCIENCE
    • G16C20/00—Chemoinformatics, i.e. ICT specially adapted for the handling of physicochemical or structural data of chemical particles, elements, compounds or mixtures
    • G16C20/20—Identification of molecular entities, parts thereof or of chemical compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803—General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6848—Methods of protein analysis involving mass spectrometry
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Theoretical Computer Science (AREA)
  • Computing Systems (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Cell Biology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Electron Tubes For Measurement (AREA)

Abstract

　親化合物と代謝物のそれぞれについてＭＳ２分析により得られたデータに基づきプロダクトイオンスペクトルを作成し（Ｓ１、Ｓ２）、さらに、各プロダクトイオンの質量とプリカーサイオンとの質量差を質量の代わりとしてニュートラルロススペクトルを作成する（Ｓ３）。親化合物と代謝物とのニュートラルロススペクトルにおいて質量が同一の共通ピークを抽出し（Ｓ４）、代謝物のプロダクトイオンスペクトル上に現れる、共通ピークの質量とプリカーサイオン質量との差の位置の相補ピークを抽出する（Ｓ５）。そして、その相補ピークに対応するイオンを次のＭＳ３分析の際のプリカーサイオンに設定し（Ｓ６）、ＭＳ３分析を実行する（Ｓ７）。開裂操作により、親化合物と代謝物との共通部分が中性分子として脱離し、差異部分がイオンとして残る場合に、差異部分のイオンをプリカーサイオンとしてＭＳ３分析を実行し、代謝部位の構造情報を得ることができる。
PCT/JP2007/001156 2007-10-23 2007-10-23 質量分析装置 WO2009054026A1 (ja)

Priority Applications (5)

Application Number Priority Date Filing Date Title
EP07827935.3A EP2208991B1 (en) 2007-10-23 2007-10-23 Mass spectrometer
JP2009537775A JP4941562B2 (ja) 2007-10-23 2007-10-23 質量分析装置
US12/739,335 US9672330B2 (en) 2007-10-23 2007-10-23 Mass spectrometer
PCT/JP2007/001156 WO2009054026A1 (ja) 2007-10-23 2007-10-23 質量分析装置
US13/946,874 US9601322B2 (en) 2007-10-23 2013-07-19 Mass spectrometer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/JP2007/001156 WO2009054026A1 (ja) 2007-10-23 2007-10-23 質量分析装置

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US11/739,335 A-371-Of-International US20070247413A1 (en) 2006-04-24 2007-04-24 Display Device
US13/946,874 Continuation-In-Part US9601322B2 (en) 2007-10-23 2013-07-19 Mass spectrometer

Publications (1)

Publication Number Publication Date
WO2009054026A1 true WO2009054026A1 (ja) 2009-04-30

Family

ID=40579136

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2007/001156 WO2009054026A1 (ja) 2007-10-23 2007-10-23 質量分析装置

Country Status (4)

Country Link
US (1) US9672330B2 (ja)
EP (1) EP2208991B1 (ja)
JP (1) JP4941562B2 (ja)
WO (1) WO2009054026A1 (ja)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011220773A (ja) * 2010-04-07 2011-11-04 Shimadzu Corp 質量分析方法及び質量分析装置
WO2013018211A1 (ja) * 2011-08-03 2013-02-07 株式会社島津製作所 質量分析データ解析方法及び装置
JP5405668B2 (ja) * 2010-07-27 2014-02-05 株式会社日立ハイテクノロジーズ イオントラップ質量分析装置および質量分析方法
JP2016003865A (ja) * 2014-06-13 2016-01-12 株式会社島津製作所 代謝物解析システム及び代謝物解析方法
JP2016070789A (ja) * 2014-09-30 2016-05-09 株式会社島津製作所 質量分析データ処理装置

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4941561B2 (ja) * 2007-10-22 2012-05-30 株式会社島津製作所 質量分析データ処理装置
WO2009081446A1 (ja) * 2007-12-20 2009-07-02 Shimadzu Corporation 質量分析システム
WO2012095948A1 (ja) * 2011-01-11 2012-07-19 株式会社島津製作所 質量分析データ解析方法、質量分析データ解析装置、及び質量分析データ解析用プログラム

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08124519A (ja) * 1994-10-21 1996-05-17 Shimadzu Corp Ｍｓ／ｍｓ質量分析装置用データ処理装置
JPH10142196A (ja) 1996-11-13 1998-05-29 Hitachi Ltd 質量分析方法および装置
JPH10293120A (ja) * 1997-04-17 1998-11-04 Hitachi Ltd 質量スペクトル表示方法，質量スペクトル表示装置，質量分析方法及び質量分析装置
JPH1164285A (ja) * 1997-08-21 1999-03-05 Shimadzu Corp 質量分析装置のデータ処理装置
JP2001249114A (ja) 1999-12-27 2001-09-14 Hitachi Ltd 質量分析方法および装置
JP2007218692A (ja) * 2006-02-15 2007-08-30 Hitachi High-Technologies Corp タンデム型質量分析システム及び方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4941561B2 (ja) * 2007-10-22 2012-05-30 株式会社島津製作所 質量分析データ処理装置

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH08124519A (ja) * 1994-10-21 1996-05-17 Shimadzu Corp Ｍｓ／ｍｓ質量分析装置用データ処理装置
JPH10142196A (ja) 1996-11-13 1998-05-29 Hitachi Ltd 質量分析方法および装置
JPH10293120A (ja) * 1997-04-17 1998-11-04 Hitachi Ltd 質量スペクトル表示方法，質量スペクトル表示装置，質量分析方法及び質量分析装置
JPH1164285A (ja) * 1997-08-21 1999-03-05 Shimadzu Corp 質量分析装置のデータ処理装置
JP2001249114A (ja) 1999-12-27 2001-09-14 Hitachi Ltd 質量分析方法および装置
JP2007218692A (ja) * 2006-02-15 2007-08-30 Hitachi High-Technologies Corp タンデム型質量分析システム及び方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GABRIELA ZUREK ET AL.: "Novel Strategies for Metabolite Identification Using HPLC-Ion Trap Mass Spectrometry", LC GCNORTH AMERICA, June 2003 (2003-06-01), pages 13 - 14, XP003022678 *
See also references of EP2208991A4 *
SHIN'ICHI YAMAGUCHI ET AL.: "Ion Trap Hiko Jikan Gata Shitsuryo Bunsekikei o Riyo shita Ekitai Chromatography Tandem Shitsuryo Bunseki Date o Mochiiru Bubun Saisho 2-joho ni yoru Taishabutsu Jido Kenshutsuho", J.MASS SPECTROM. SOC. JPN, vol. 55, no. 2, 12 January 2007 (2007-01-12), pages 83 - 89, XP008134026 *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011220773A (ja) * 2010-04-07 2011-11-04 Shimadzu Corp 質量分析方法及び質量分析装置
JP5405668B2 (ja) * 2010-07-27 2014-02-05 株式会社日立ハイテクノロジーズ イオントラップ質量分析装置および質量分析方法
US8704166B2 (en) 2010-07-27 2014-04-22 Hitachi High-Technologies Corporation Ion trap type mass spectrometer and mass spectrometry
WO2013018211A1 (ja) * 2011-08-03 2013-02-07 株式会社島津製作所 質量分析データ解析方法及び装置
JP2016003865A (ja) * 2014-06-13 2016-01-12 株式会社島津製作所 代謝物解析システム及び代謝物解析方法
JP2016070789A (ja) * 2014-09-30 2016-05-09 株式会社島津製作所 質量分析データ処理装置
US10453227B2 (en) 2014-09-30 2019-10-22 Shimadzu Corporation Mass spectrometry data processing apparatus

Also Published As

Publication number Publication date
EP2208991B1 (en) 2017-10-04
JPWO2009054026A1 (ja) 2011-03-03
EP2208991A1 (en) 2010-07-21
EP2208991A4 (en) 2012-05-02
JP4941562B2 (ja) 2012-05-30
US20100312489A1 (en) 2010-12-09
US9672330B2 (en) 2017-06-06

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