WO2009036714A1 - Composition pour le traitement de plaies, contenant au moins de l'argent et de l'urée - Google Patents

Composition pour le traitement de plaies, contenant au moins de l'argent et de l'urée Download PDF

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Publication number
WO2009036714A1
WO2009036714A1 PCT/DE2008/001083 DE2008001083W WO2009036714A1 WO 2009036714 A1 WO2009036714 A1 WO 2009036714A1 DE 2008001083 W DE2008001083 W DE 2008001083W WO 2009036714 A1 WO2009036714 A1 WO 2009036714A1
Authority
WO
WIPO (PCT)
Prior art keywords
silver
composition
urea
wounds
hyaluronic acid
Prior art date
Application number
PCT/DE2008/001083
Other languages
German (de)
English (en)
Inventor
Peter G. Deckner
Original Assignee
Deckner Peter G
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Deckner Peter G filed Critical Deckner Peter G
Publication of WO2009036714A1 publication Critical patent/WO2009036714A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
    • A61K31/728—Hyaluronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/38—Silver; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like

Definitions

  • compositions known from the prior art their efficacy may be given on an individual basis, but on a broad basis they are not effective, which is due to the still enormous number of patients with bad or non-healing wounds see is.
  • a treatment solution for chronic wound treatment can be found in DE 101 40 623 A1.
  • the treatment solution is an aqueous solution containing per liter of solution besides water and preferably sulfuric acid 10 to 100 mg of zinc, 6.5 to 65 mg of iron and in a further development the growth factor PDGF.
  • the proportion of acid is adjusted so that the pH is between 2.5 and 3.5.
  • a composition for wound treatment with a proportion of silver salt compounds can be taken from WO 2006/034249 A2.
  • composition contains, in addition to the abovementioned substances, at least one physiologically and pharmacologically acceptable carrier or excipient.
  • composition according to the invention may comprise further active ingredients and / or ingredients familiar to the person skilled in the art, in particular processing substances, stabilizers, emulsifiers, antiseptics, antioxidants, preservatives, humectants or the like.
  • composition for wound treatment characterized in that it contains up to 0.9 g hyaluronic acid, 0.1 to 40.0 g urea and 0.1 g to Ig colloidal silver.
  • composition according to the invention can be present in various forms, ie as spray, ointment, gel, suspension, powder, washing lotion, tincture, gauze, wound dressing, impregnated wound dressing, foam or sponge.
  • spray ointment
  • gel suspension
  • powder washing lotion
  • tincture gauze
  • wound dressing impregnated wound dressing
  • foam or sponge for more details on the terms ointment, paste, cream, gel reference is made to the relevant keywords in Römpp, Lexicon Chemistry 10th edition, Georg Thieme Verlag, Stuttgart / New York.
  • the composition brings about local antibiosis (sterility), wound cleansing, the dissolution of necroses, granulation promotion, the protection of the wound and the wound environment, and epithelization (stable strengthening of the cell complex).
  • composition in spray form allows the use of a button probe with which the spray is applied e.g. can be applied to fistulas in fistula canals, wound bags, deep and ragged wounds, anal areas, poorly accessible wounds, body cavities and pressure sores.
  • composition for an ointment Composition for an ointment
  • composition according to the invention it is also possible to heal open wounds for years within a few months.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne une composition pour le traitement de plaies, contenant de l'acide hyaluronique, de l'urée et de l'argent colloïdal.
PCT/DE2008/001083 2007-09-19 2008-06-27 Composition pour le traitement de plaies, contenant au moins de l'argent et de l'urée WO2009036714A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102007044582.4 2007-09-19
DE102007044582A DE102007044582A1 (de) 2007-09-19 2007-09-19 Zusammensetzung für Wundbehandlungen im Humanbereich

Publications (1)

Publication Number Publication Date
WO2009036714A1 true WO2009036714A1 (fr) 2009-03-26

Family

ID=39938115

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE2008/001083 WO2009036714A1 (fr) 2007-09-19 2008-06-27 Composition pour le traitement de plaies, contenant au moins de l'argent et de l'urée

Country Status (2)

Country Link
DE (1) DE102007044582A1 (fr)
WO (1) WO2009036714A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010127647A1 (fr) * 2009-05-08 2010-11-11 Deckner Peter G Composition destinée au traitement de blessures en médecine humaine et vétérinaire
EP2371350A1 (fr) 2010-03-04 2011-10-05 Neubourg Skin Care GmbH & Co. KG Formulations à base de mousse pour le traitement de maladies de peau chez les animaux
CN102343085A (zh) * 2010-08-02 2012-02-08 龚森淼 一种治疗皮肤创伤的水包油o/w乳液及其制造方法
WO2013017808A1 (fr) * 2011-08-04 2013-02-07 Dermaconcept Jmc Composition antiseptique.
US9108854B2 (en) 2009-09-22 2015-08-18 Prebona Ab Biocidal colloidal dispersions of silica particles with silver ions adsorbed thereon
RU2611046C2 (ru) * 2010-11-19 2017-02-20 Фидиа Фармачеутичи С.П.А. Композиции с антибактериальной и ранозаживляющей активностью
WO2019122429A1 (fr) 2017-12-21 2019-06-27 Prebona Ab Composition pharmaceutique comprenant une dispersion colloïdale et un agent thérapeutique, et procédés et utilisations de celle-ci
US11191776B1 (en) * 2013-10-23 2021-12-07 Donald Wayne Jessup Hyaluronic acid formulation

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047737A1 (fr) * 2000-12-12 2002-06-20 Johnson & Johnson Medical Limited Pansement pour traitement de plaies suintantes
WO2006034249A2 (fr) * 2004-09-20 2006-03-30 Acrymed, Inc. Compositions antimicrobiennes amorphes
WO2006135506A2 (fr) * 2005-06-08 2006-12-21 Collegium Pharmaceutical, Inc. Compositions pour debridement enzymatique topique

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5550112A (en) * 1992-12-30 1996-08-27 Patent Biopharmaceutics, Inc. Hyaluronic acid-urea pharmaceutical compositions and uses
DE10140623A1 (de) 2001-08-18 2003-03-06 Nawa Heilmittel Gmbh Pharmazeutisches Präparat zur Behandlung von Wunden
DE102005008299A1 (de) * 2005-02-23 2006-12-28 Icb Investment Consulting Beteiligungen Gmbh Universalpflegecreme
WO2008075207A2 (fr) * 2006-04-04 2008-06-26 Foamix Ltd. Composition expansible d'augmentation anti-infectieuse, et kits et utilisations de celle-ci
DE102006032887A1 (de) * 2006-07-15 2008-01-17 Metacura Fze Verwendung einer Zubereitung aus Calciumhydroxid und Öl zur Hautwundversorgung
DE102006045389A1 (de) * 2006-09-26 2008-03-27 Maxim Markenprodukte Gmbh & Co. Kg Dermatologische Feuchthaltemittel

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002047737A1 (fr) * 2000-12-12 2002-06-20 Johnson & Johnson Medical Limited Pansement pour traitement de plaies suintantes
WO2006034249A2 (fr) * 2004-09-20 2006-03-30 Acrymed, Inc. Compositions antimicrobiennes amorphes
WO2006135506A2 (fr) * 2005-06-08 2006-12-21 Collegium Pharmaceutical, Inc. Compositions pour debridement enzymatique topique

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
ATIYEH ET AL: "Effect of silver on burn wound infection control and healing: Review of the literature", BURNS, BUTTERWORTH HEINEMANN, GB, vol. 33, no. 2, 3 February 2007 (2007-02-03), pages 139 - 148, XP005873104, ISSN: 0305-4179 *
DATABASE BIOSIS [online] BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US; 1996, UDASI S D ET AL: "Efficacy of different concentrations of 'urea solution' in the treatment of wounds", XP002510575, Database accession no. PREV199799291163 *
HOLDER H G ET AL: "THE APPLICATION OF CARBAMIDE (UREA) THERAPY IN WOUND HEALING.", ANNALS OF SURGERY JUL 1939, vol. 110, no. 1, July 1939 (1939-07-01), pages 94 - 99, XP009110707, ISSN: 0003-4932 *
MANUSKIATTI W ET AL: "Hyaluronic acid and skin: wound healing and aging.", INTERNATIONAL JOURNAL OF DERMATOLOGY AUG 1996, vol. 35, no. 8, August 1996 (1996-08-01), pages 539 - 544, XP009072440, ISSN: 0011-9059 *

Cited By (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010127647A1 (fr) * 2009-05-08 2010-11-11 Deckner Peter G Composition destinée au traitement de blessures en médecine humaine et vétérinaire
US9108854B2 (en) 2009-09-22 2015-08-18 Prebona Ab Biocidal colloidal dispersions of silica particles with silver ions adsorbed thereon
EP2371350A1 (fr) 2010-03-04 2011-10-05 Neubourg Skin Care GmbH & Co. KG Formulations à base de mousse pour le traitement de maladies de peau chez les animaux
CN102343085A (zh) * 2010-08-02 2012-02-08 龚森淼 一种治疗皮肤创伤的水包油o/w乳液及其制造方法
RU2611046C2 (ru) * 2010-11-19 2017-02-20 Фидиа Фармачеутичи С.П.А. Композиции с антибактериальной и ранозаживляющей активностью
WO2013017808A1 (fr) * 2011-08-04 2013-02-07 Dermaconcept Jmc Composition antiseptique.
WO2013017807A1 (fr) * 2011-08-04 2013-02-07 Petcare Innovation Composition antiseptique
FR2978664A1 (fr) * 2011-08-04 2013-02-08 Petcare Innovation Composition antiseptique
FR2978665A1 (fr) * 2011-08-04 2013-02-08 Petcare Innovation Composition antiseptique
US11191776B1 (en) * 2013-10-23 2021-12-07 Donald Wayne Jessup Hyaluronic acid formulation
WO2019122429A1 (fr) 2017-12-21 2019-06-27 Prebona Ab Composition pharmaceutique comprenant une dispersion colloïdale et un agent thérapeutique, et procédés et utilisations de celle-ci

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Publication number Publication date
DE102007044582A1 (de) 2009-04-09

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