WO2009021083A8 - Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases - Google Patents

Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases Download PDF

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Publication number
WO2009021083A8
WO2009021083A8 PCT/US2008/072401 US2008072401W WO2009021083A8 WO 2009021083 A8 WO2009021083 A8 WO 2009021083A8 US 2008072401 W US2008072401 W US 2008072401W WO 2009021083 A8 WO2009021083 A8 WO 2009021083A8
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Prior art keywords
quinoxaline derivatives
diseases
kinase inhibitors
invented
pancreatitis
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PCT/US2008/072401
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English (en)
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WO2009021083A1 (fr
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Steven David Knight
Cynthia A Parrish
Lance H Ridgers
Martha A Sarpong
Amita M Chaudhari
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Smithkline Beecham Corp
Steven David Knight
Cynthia A Parrish
Lance H Ridgers
Martha A Sarpong
Amita M Chaudhari
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Application filed by Smithkline Beecham Corp, Steven David Knight, Cynthia A Parrish, Lance H Ridgers, Martha A Sarpong, Amita M Chaudhari filed Critical Smithkline Beecham Corp
Priority to JP2010520295A priority Critical patent/JP2010535804A/ja
Priority to EP08797323A priority patent/EP2173354A4/fr
Publication of WO2009021083A1 publication Critical patent/WO2009021083A1/fr
Publication of WO2009021083A8 publication Critical patent/WO2009021083A8/fr

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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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Abstract

Cette invention se rapporte à un procédé d'inhibition de l'activité/de la fonction des PI3-kinases utilisant des dérivés des quinoxalines. L'invention concerne également un procédé permettant de traiter une ou plusieurs des affections pathologiques suivantes : les maladies auto-immunes, les maladies inflammatoires, les maladies cardiovasculaires, les maladies neurodégénératives, l'allergie, l'asthme, la pancréatite, la défaillance multiviscérale, les maladies rénales, l'agrégation plaquettaire, le cancer, la motilité de sperme, le rejet de greffe, le rejet du greffon et les lésions pulmonaires, en administrant des dérivés des quinoxalines.
PCT/US2008/072401 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases WO2009021083A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2010520295A JP2010535804A (ja) 2007-08-09 2008-08-07 Ｐｉ３キナーゼ阻害薬としてのキノキサリン誘導体
EP08797323A EP2173354A4 (fr) 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US95484507P 2007-08-09 2007-08-09
US60/954,845 2007-08-09

Publications (2)

Publication Number Publication Date
WO2009021083A1 WO2009021083A1 (fr) 2009-02-12
WO2009021083A8 true WO2009021083A8 (fr) 2009-04-09

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PCT/US2008/072401 WO2009021083A1 (fr) 2007-08-09 2008-08-07 Dérivés des quinoxalines utilisés comme inhibiteurs des pi3-kinases

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EP (1) EP2173354A4 (fr)
JP (1) JP2010535804A (fr)
WO (1) WO2009021083A1 (fr)

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US9533954B2 (en) 2010-12-22 2017-01-03 Incyte Corporation Substituted imidazopyridazines and benzimidazoles as inhibitors of FGFR3
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12024517B2 (en) 2021-10-18 2024-07-02 Incyte Corporation Salts of an FGFR inhibitor

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EP2473498A1 (fr) * 2009-09-04 2012-07-11 Bayer Pharma Aktiengesellschaft Aminoquinoxalines substituées servant d'inhibiteurs de tyrosine-thréonine kinases
GB201007286D0 (en) 2010-04-30 2010-06-16 Astex Therapeutics Ltd New compounds
GB201020179D0 (en) * 2010-11-29 2011-01-12 Astex Therapeutics Ltd New compounds
GB201118654D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
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GB201118652D0 (en) 2011-10-28 2011-12-07 Astex Therapeutics Ltd New compounds
ES2605946T3 (es) 2012-03-14 2017-03-17 Bayer Intellectual Property Gmbh Imidazopiridazinas sustituidas
GB201209609D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
GB201209613D0 (en) 2012-05-30 2012-07-11 Astex Therapeutics Ltd New compounds
PT3495367T (pt) 2012-06-13 2020-11-12 Incyte Holdings Corp Compostos tricíclicos substituídos como inibidores de fgfr
WO2014026125A1 (fr) 2012-08-10 2014-02-13 Incyte Corporation Dérivés de pyrazine en tant qu'inhibiteurs de fgfr
EP2882722B1 (fr) 2012-08-13 2016-07-27 Takeda Pharmaceutical Company Limited Dérivés de quinoxaline en tant que modulateurs du gpr6
US9266892B2 (en) 2012-12-19 2016-02-23 Incyte Holdings Corporation Fused pyrazoles as FGFR inhibitors
CA2900303A1 (fr) 2013-02-07 2014-08-14 Merck Patent Gmbh Derives de quinoxaline substitues et leur utilisation a titre de modulateurs allosteriques positifs du mglur4
TWI715901B (zh) 2013-04-19 2021-01-11 美商英塞特控股公司 作為ｆｇｆｒ抑制劑之雙環雜環
GB201307577D0 (en) 2013-04-26 2013-06-12 Astex Therapeutics Ltd New compounds
PE20160156A1 (es) 2013-06-11 2016-04-20 Bayer Pharma AG Derivados de prodroga de triazolpiridinas sustituidas
WO2015059088A1 (fr) * 2013-10-23 2015-04-30 Bayer Cropscience Ag Dérivés de chinoxaline substitués servant d'agent de lutte antiparasitaire
EP3105230B1 (fr) 2014-02-14 2021-04-07 Takeda Pharmaceutical Company Limited Modulateurs pyridopyrazines de gpr6
HUE053653T2 (hu) 2014-03-26 2021-07-28 Astex Therapeutics Ltd FGFR inhibitor és IGF1R inhibitor kombinációi
EP3848034A1 (fr) 2014-03-26 2021-07-14 Astex Therapeutics Limited Combinaisons
JO3512B1 (ar) 2014-03-26 2020-07-05 Astex Therapeutics Ltd مشتقات كينوكسالين مفيدة كمعدلات لإنزيم fgfr كيناز
US10851105B2 (en) 2014-10-22 2020-12-01 Incyte Corporation Bicyclic heterocycles as FGFR4 inhibitors
JOP20200201A1 (ar) 2015-02-10 2017-06-16 Astex Therapeutics Ltd تركيبات صيدلانية تشتمل على n-(3.5- ثنائي ميثوكسي فينيل)-n'-(1-ميثيل إيثيل)-n-[3-(ميثيل-1h-بيرازول-4-يل) كينوكسالين-6-يل]إيثان-1.2-ثنائي الأمين
CN113004278B (zh) 2015-02-20 2023-07-21 因赛特控股公司 作为fgfr抑制剂的双环杂环
MA41551A (fr) 2015-02-20 2017-12-26 Incyte Corp Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
WO2016134294A1 (fr) 2015-02-20 2016-08-25 Incyte Corporation Hétérocycles bicycliques utilisés en tant qu'inhibiteurs de fgfr4
US10478494B2 (en) 2015-04-03 2019-11-19 Astex Therapeutics Ltd FGFR/PD-1 combination therapy for the treatment of cancer
KR20180030913A (ko) * 2015-07-30 2018-03-26 브리스톨-마이어스 스큅 컴퍼니 아릴 치환된 비시클릭 헤테로아릴 화합물
CN108137546B (zh) 2015-09-23 2021-07-27 詹森药业有限公司 双杂芳基取代的1,4-苯并二氮杂卓化合物及其用于治疗癌症的用途
CA2996857C (fr) 2015-09-23 2024-05-21 Janssen Pharmaceutica Nv Composes derives de la quinoxaline, de la quinoleine et de la quinazolin one pour le traitement du cancer
WO2017060406A1 (fr) * 2015-10-09 2017-04-13 Janssen Pharmaceutica Nv Dérivés de quinoxaline et de pyridopyrazine à titre d'inhibiteurs de pi3kβ
KR102472453B1 (ko) 2016-06-16 2022-11-29 얀센 파마슈티카 엔.브이. Pi3k 베타 저해제로서의 이환식 피리딘, 피라진, 및 피리미딘 유도체
KR102472198B1 (ko) 2016-06-16 2022-11-28 얀센 파마슈티카 엔.브이. Pi3k 베타 저해제로서의 아자벤즈이미다졸 유도체
KR20190133729A (ko) 2017-03-29 2019-12-03 얀센 파마슈티카 엔.브이. Pi3k-베타 억제제로서 퀴녹살린 및 피리도피라진 유도체
AR111960A1 (es) 2017-05-26 2019-09-04 Incyte Corp Formas cristalinas de un inhibidor de fgfr y procesos para su preparación
CR20200591A (es) 2018-05-04 2021-03-31 Incyte Corp Sales de un inhibidor de fgfr
WO2019213544A2 (fr) 2018-05-04 2019-11-07 Incyte Corporation Formes solides d'un inhibiteur de fgfr et leurs procédés de préparation
WO2020185532A1 (fr) 2019-03-08 2020-09-17 Incyte Corporation Méthodes de traitement du cancer au moyen d'un inhibiteur de fgfr
TW202128685A (zh) 2019-10-14 2021-08-01 美商英塞特公司 作為ｆｇｆｒ抑制劑之雙環雜環
EP4069696A1 (fr) 2019-12-04 2022-10-12 Incyte Corporation Hétérocycles tricycliques en tant qu'inhibiteurs de fgfr
CA3162010A1 (fr) 2019-12-04 2021-06-10 Incyte Corporation Derives d'un inhibiteur de fgfr
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US12012409B2 (en) 2020-01-15 2024-06-18 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
CA3220274A1 (fr) 2021-06-09 2022-12-15 Incyte Corporation Heterocycles tricycliques en tant qu'inhibiteurs de fgfr
CN114605391B (zh) * 2022-02-21 2024-01-26 广州六顺生物科技股份有限公司 喹喔啉类衍生物及其制备方法和应用

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US11591329B2 (en) 2019-07-09 2023-02-28 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US11566028B2 (en) 2019-10-16 2023-01-31 Incyte Corporation Bicyclic heterocycles as FGFR inhibitors
US12024517B2 (en) 2021-10-18 2024-07-02 Incyte Corporation Salts of an FGFR inhibitor

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