WO2009011617A3 - АННЕЛИРОВАННЫЕ АЗАГЕТЕРОЦИКЛЫ, ВКЛЮЧАЮЩИЕ ПИРИМИДИНОВЫЙ ФРАГМЕНТ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИНГИБИТОРЫ РIЗКs КИНАЗ - Google Patents

АННЕЛИРОВАННЫЕ АЗАГЕТЕРОЦИКЛЫ, ВКЛЮЧАЮЩИЕ ПИРИМИДИНОВЫЙ ФРАГМЕНТ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИНГИБИТОРЫ РIЗКs КИНАЗ Download PDF

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Publication number
WO2009011617A3
WO2009011617A3 PCT/RU2008/000468 RU2008000468W WO2009011617A3 WO 2009011617 A3 WO2009011617 A3 WO 2009011617A3 RU 2008000468 W RU2008000468 W RU 2008000468W WO 2009011617 A3 WO2009011617 A3 WO 2009011617A3
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WO
WIPO (PCT)
Prior art keywords
optionally substituted
annelated
atom
azaheterocycles
pi3ks
Prior art date
Application number
PCT/RU2008/000468
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English (en)
French (fr)
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WO2009011617A2 (ru
Inventor
Alexander Vasiliev Ivashchenko
Sergey Yevgenievich Tkachenko
Ilya Matusovich Okun
Nikolay Filippovich Savchuk
Andrey Alexandrovich Ivaschenko
Dmitri Vladimirovich Kravchenko
Oleg Schmidt-Kittler
Carlo Rago
Nickolas Papadopoulos
Victor Velcuelsu
Bert Vogelstein
Kenneth W Kinzler
Andrey Sergeevich Trifilenkov
Elena Alexandrovna Rizhova
Zhu Jiuxiang
Original Assignee
Chemical Diversity Res Inst Jo
Alexander Vasiliev Ivashchenko
Sergey Yevgenievich Tkachenko
Ilya Matusovich Okun
Nikolay Filippovich Savchuk
Ivaschenko Andrey Alexandrovic
Kravchenko Dmitri Vladimirovic
Oleg Schmidt-Kittler
Carlo Rago
Nickolas Papadopoulos
Victor Velcuelsu
Bert Vogelstein
Kenneth W Kinzler
Andrey Sergeevich Trifilenkov
Elena Alexandrovna Rizhova
Zhu Jiuxiang
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Chemical Diversity Res Inst Jo, Alexander Vasiliev Ivashchenko, Sergey Yevgenievich Tkachenko, Ilya Matusovich Okun, Nikolay Filippovich Savchuk, Ivaschenko Andrey Alexandrovic, Kravchenko Dmitri Vladimirovic, Oleg Schmidt-Kittler, Carlo Rago, Nickolas Papadopoulos, Victor Velcuelsu, Bert Vogelstein, Kenneth W Kinzler, Andrey Sergeevich Trifilenkov, Elena Alexandrovna Rizhova, Zhu Jiuxiang filed Critical Chemical Diversity Res Inst Jo
Publication of WO2009011617A2 publication Critical patent/WO2009011617A2/ru
Publication of WO2009011617A3 publication Critical patent/WO2009011617A3/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C07D491/147—Ortho-condensed systems the condensed system containing one ring with oxygen as ring hetero atom and two rings with nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Abstract

6 алкил, или Z представляет собой атом азота, который вместе с атомом углерода, с которым он связан, и Rl, вместе с атомом азота, с которым он связан, замыкают через Z и Rl необязательно замещенный аннелированный имидазолиновый цикл; R2 представляет собой необязательно замещенный алкил, необязательно замещенный циклоалкил, необязательно замещенный арил, необязательно замещенный гетероциклил.
PCT/RU2008/000468 2007-07-17 2008-07-16 АННЕЛИРОВАННЫЕ АЗАГЕТЕРОЦИКЛЫ, ВКЛЮЧАЮЩИЕ ПИРИМИДИНОВЫЙ ФРАГМЕНТ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИНГИБИТОРЫ РIЗКs КИНАЗ WO2009011617A2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
RU2007127188 2007-07-17
RU2007127188/04A RU2341527C1 (ru) 2007-07-17 2007-07-17 Аннелированные азагетероциклы, включающие пиримидиновый фрагмент, способ их получения и ингибиторы pi3k киназ

Publications (2)

Publication Number Publication Date
WO2009011617A2 WO2009011617A2 (ru) 2009-01-22
WO2009011617A3 true WO2009011617A3 (ru) 2009-03-12

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PCT/RU2008/000468 WO2009011617A2 (ru) 2007-07-17 2008-07-16 АННЕЛИРОВАННЫЕ АЗАГЕТЕРОЦИКЛЫ, ВКЛЮЧАЮЩИЕ ПИРИМИДИНОВЫЙ ФРАГМЕНТ, СПОСОБ ИХ ПОЛУЧЕНИЯ И ИНГИБИТОРЫ РIЗКs КИНАЗ

Country Status (2)

Country Link
RU (1) RU2341527C1 (ru)
WO (1) WO2009011617A2 (ru)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT2790705T (pt) 2011-12-15 2018-01-24 Novartis Ag Utilização de inibidores da atividade ou função de pi3k
TWI770525B (zh) 2014-12-30 2022-07-11 美商瓦洛健康公司 作為泛素特異性蛋白酶７抑制劑之吡咯并及吡唑并嘧啶
MA41291A (fr) 2014-12-30 2017-11-07 Forma Therapeutics Inc Dérivés de la pyrrolotriazinone et de l'imidazotriazinone en tant qu'inhibiteurs de la protéase spécifique de l'ubiquitine n° 7 (usp7) pour le traitement d'un cancer
WO2016126926A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Quinazolinones and azaquinazolinones as ubiquitin-specific protease 7 inhibitors
US9938300B2 (en) 2015-02-05 2018-04-10 Forma Therapeutics, Inc. Isothiazolopyrimidinones, pyrazolopyrimidinones, and pyrrolopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2016126929A1 (en) 2015-02-05 2016-08-11 Forma Therapeutics, Inc. Thienopyrimidinones as ubiquitin-specific protease 7 inhibitors
WO2020106625A1 (en) * 2018-11-19 2020-05-28 Xios Therapeutics, Inc. Compounds and uses thereof
US20220332720A1 (en) * 2019-08-21 2022-10-20 The Scripps Research Institute Bicyclic agonists of stimulator of interferon genes sting
CN111281873B (zh) * 2020-01-20 2021-01-26 浙江大学 Dna甲基转移酶3a抑制剂及其应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2158127C2 (ru) * 1994-12-23 2000-10-27 Варнер-Ламберт Компани Способы ингибирования тирозинкиназы рецептора эпидермального фактора роста, азотсодержащие трициклические соединения, фармацевтическая композиция, предназначенная для введения ингибитора тирозинкиназы рецептора эпидермального фактора роста, например, erb-b2, erb-b3 или erb-b4, и противозачаточная композиция
WO2003011868A1 (en) * 2001-07-28 2003-02-13 Astrazeneca Ab Thienopyrimidinediones and their use in the modulation of autoimmune disease
WO2003074530A1 (en) * 2002-03-07 2003-09-12 F. Hoffman-La Roche Ag Bicyclic pyridine and pyrimidine p38 kinase inhibitors

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2158127C2 (ru) * 1994-12-23 2000-10-27 Варнер-Ламберт Компани Способы ингибирования тирозинкиназы рецептора эпидермального фактора роста, азотсодержащие трициклические соединения, фармацевтическая композиция, предназначенная для введения ингибитора тирозинкиназы рецептора эпидермального фактора роста, например, erb-b2, erb-b3 или erb-b4, и противозачаточная композиция
WO2003011868A1 (en) * 2001-07-28 2003-02-13 Astrazeneca Ab Thienopyrimidinediones and their use in the modulation of autoimmune disease
WO2003074530A1 (en) * 2002-03-07 2003-09-12 F. Hoffman-La Roche Ag Bicyclic pyridine and pyrimidine p38 kinase inhibitors

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RU2341527C1 (ru) 2008-12-20
WO2009011617A2 (ru) 2009-01-22

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