WO2009008414A1 - Mmp13に対する中和活性を有するモノクローナル抗体 - Google Patents
Mmp13に対する中和活性を有するモノクローナル抗体 Download PDFInfo
- Publication number
- WO2009008414A1 WO2009008414A1 PCT/JP2008/062306 JP2008062306W WO2009008414A1 WO 2009008414 A1 WO2009008414 A1 WO 2009008414A1 JP 2008062306 W JP2008062306 W JP 2008062306W WO 2009008414 A1 WO2009008414 A1 WO 2009008414A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- mmp13
- neutralizing
- antibody
- monoclonal antibody
- activity against
- Prior art date
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/81—Protease inhibitors
- G01N2333/8107—Endopeptidase (E.C. 3.4.21-99) inhibitors
- G01N2333/8146—Metalloprotease (E.C. 3.4.24) inhibitors, e.g. tissue inhibitor of metallo proteinase, TIMP
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Urology & Nephrology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Genetics & Genomics (AREA)
- Food Science & Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Physics & Mathematics (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Physical Education & Sports Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
MMP13と特異的に反応する中和モノクローナル抗体、該抗体を用いたMMP13の酵素活性中和方法及び免疫学的測定方法、並びに該抗体を含有した診断薬及び医薬組成物を提供する。 これまでMMP13に対する種々の抗体が得られてきたがMMP13に対して中和活性を有する抗体を得られていなかった。本発明者等が鋭意検討した結果、MMP13に対して特異性を有する中和抗体を見出して本発明を完成するに至った。
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08790943A EP2186894A4 (en) | 2007-07-10 | 2008-07-08 | MONOCLONAL ANTIBODY HAVING NEUTRALIZING ACTIVITY AGAINST MMP13 |
JP2009522646A JP5354680B2 (ja) | 2007-07-10 | 2008-07-08 | Mmp13に対する中和活性を有するモノクローナル抗体 |
US12/668,201 US8536313B2 (en) | 2007-07-10 | 2008-07-08 | Monoclonal antibody having neutralizing activity against MMP13 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2007180784 | 2007-07-10 | ||
JP2007-180784 | 2007-07-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2009008414A1 true WO2009008414A1 (ja) | 2009-01-15 |
Family
ID=40228584
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP2008/062306 WO2009008414A1 (ja) | 2007-07-10 | 2008-07-08 | Mmp13に対する中和活性を有するモノクローナル抗体 |
Country Status (4)
Country | Link |
---|---|
US (1) | US8536313B2 (ja) |
EP (1) | EP2186894A4 (ja) |
JP (1) | JP5354680B2 (ja) |
WO (1) | WO2009008414A1 (ja) |
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013541534A (ja) * | 2010-10-01 | 2013-11-14 | ラーマン,サルマン | 治療および診断用途のためのメトジンシン選択性の触媒クレフト特異的抗体の生成方法 |
CN110997001A (zh) * | 2017-06-02 | 2020-04-10 | 默克专利股份有限公司 | Mmp13结合免疫球蛋白 |
JP2020523986A (ja) * | 2017-06-02 | 2020-08-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Adamts5、mmp13およびアグリカンに結合するポリペプチド |
JP2021118721A (ja) * | 2015-08-28 | 2021-08-12 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 様々ながんの免疫治療で使用するための新規ペプチド、ペプチドおよびスキャフォールド組み合わせ |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9040049B2 (en) | 2008-03-24 | 2015-05-26 | Vasgen Limited | ADAM-15 antibodies and immunogenic peptides |
WO2012048291A2 (en) | 2010-10-08 | 2012-04-12 | Proteapex Therapeutics Llc | Compositions and methods for inhibition of mmp:mmp-substrate interactions |
Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0239747A (ja) | 1988-07-29 | 1990-02-08 | Meidensha Corp | 時刻情報伝送方式 |
JPH04504365A (ja) | 1990-01-12 | 1992-08-06 | アブジェニックス インコーポレイテッド | 異種抗体の生成 |
JPH06500233A (ja) | 1990-08-29 | 1994-01-13 | ジェンファーム インターナショナル,インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス,インク. | 異種抗体の生産 |
WO1996002576A1 (fr) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre l'interleukine-8 humaine |
WO1998029560A1 (fr) | 1996-12-26 | 1998-07-09 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Anticorps monoclonal contre la collagenase 3 et procede de dosage immunologique utilisant cet anticorps |
WO2000008704A1 (en) | 1998-08-06 | 2000-02-17 | Hawker Energy Products, Inc. | Wound lead acid battery with non-circular cells |
WO2007065037A2 (en) * | 2005-12-02 | 2007-06-07 | Curagen Corporation | Antibodies against mmp-13 (collagenase-3) and uses thereof |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE517926T1 (de) | 2003-04-04 | 2011-08-15 | Yeda Res & Dev | Antikörper zur hemmung der aktivität von mmp-2 und mmp-9 |
-
2008
- 2008-07-08 WO PCT/JP2008/062306 patent/WO2009008414A1/ja active Application Filing
- 2008-07-08 US US12/668,201 patent/US8536313B2/en not_active Expired - Fee Related
- 2008-07-08 JP JP2009522646A patent/JP5354680B2/ja not_active Expired - Fee Related
- 2008-07-08 EP EP08790943A patent/EP2186894A4/en not_active Withdrawn
Patent Citations (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH0239747A (ja) | 1988-07-29 | 1990-02-08 | Meidensha Corp | 時刻情報伝送方式 |
JPH04504365A (ja) | 1990-01-12 | 1992-08-06 | アブジェニックス インコーポレイテッド | 異種抗体の生成 |
JPH06500233A (ja) | 1990-08-29 | 1994-01-13 | ジェンファーム インターナショナル,インコーポレイティド | 異種免疫グロブリンを作る方法及びトランスジェニックマウス |
JPH07509137A (ja) | 1992-07-24 | 1995-10-12 | セル ジェネシス,インク. | 異種抗体の生産 |
WO1994025585A1 (en) | 1993-04-26 | 1994-11-10 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
WO1996002576A1 (fr) | 1994-07-13 | 1996-02-01 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre l'interleukine-8 humaine |
WO1998029560A1 (fr) | 1996-12-26 | 1998-07-09 | Fuji Yakuhin Kogyo Kabushiki Kaisha | Anticorps monoclonal contre la collagenase 3 et procede de dosage immunologique utilisant cet anticorps |
WO2000008704A1 (en) | 1998-08-06 | 2000-02-17 | Hawker Energy Products, Inc. | Wound lead acid battery with non-circular cells |
WO2007065037A2 (en) * | 2005-12-02 | 2007-06-07 | Curagen Corporation | Antibodies against mmp-13 (collagenase-3) and uses thereof |
Non-Patent Citations (13)
Title |
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"Immunochemistry in Practice", BLACKWELL SCIENTIFIC PUBLICATIONS |
"Molecular Cloning: A Laboratory Manual", COLD SPRING HARBOR LABORATORY |
"principle of various methods described in enzyme immunoassay", 1987, IGAKU-SHOIN LTD. |
J. BIOL. CHEM., vol. 269, 1994, pages 16766 - 16773 |
J. CLIN. INVEST., vol. 99, no. 7, 1997, pages 1584 - 1545 |
LEEMAN M.F. ET AL.: "The structure, regulation, and function of human matrix metalloproteinase-13", CRIT. REV. BIOCHEM. MOL. BIOL., vol. 37, no. 3, 2002, pages 149 - 166, XP009138150 * |
MASKOS K. ET AL.: "Flexibility and variability of TIMP binding: X-ray structure of the complex between collagenase-3/MMP-13 and TIMP-2", J. MOL. BIOL., vol. 366, no. 4, 2007, pages 1222 - 1231, XP025680012 * |
NATURE GENETICS, vol. 15, 1997, pages 146 - 156 |
NATURE GENETICS, vol. 7, 1994, pages 13 - 21 |
NATURE, vol. 368, 1994, pages 856 - 859 |
NIKKEI, SCIENCE, June 1995 (1995-06-01), pages 40 - 50 |
OSTEOARTHRITIS AND CARTILAGE, vol. 11, no. 9, 2003, pages 673 - 680 |
See also references of EP2186894A4 |
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013541534A (ja) * | 2010-10-01 | 2013-11-14 | ラーマン,サルマン | 治療および診断用途のためのメトジンシン選択性の触媒クレフト特異的抗体の生成方法 |
JP2021118721A (ja) * | 2015-08-28 | 2021-08-12 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 様々ながんの免疫治療で使用するための新規ペプチド、ペプチドおよびスキャフォールド組み合わせ |
AU2020201896B2 (en) * | 2015-08-28 | 2022-08-25 | Immatics Biotechnologies Gmbh | Novel peptides, combination of peptides and scaffolds for use in immunotherapeutic treatment of various cancers |
JP7506026B2 (ja) | 2015-08-28 | 2024-06-25 | イマティクス バイオテクノロジーズ ゲーエムベーハー | 様々ながんの免疫治療で使用するための新規ペプチド、ペプチドおよびスキャフォールド組み合わせ |
CN110997001A (zh) * | 2017-06-02 | 2020-04-10 | 默克专利股份有限公司 | Mmp13结合免疫球蛋白 |
JP2020521804A (ja) * | 2017-06-02 | 2020-07-27 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Mmp13結合免疫グロブリン |
JP2020523986A (ja) * | 2017-06-02 | 2020-08-13 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Adamts5、mmp13およびアグリカンに結合するポリペプチド |
JP7249961B2 (ja) | 2017-06-02 | 2023-03-31 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング | Adamts5、mmp13およびアグリカンに結合するポリペプチド |
US11813307B2 (en) | 2017-06-02 | 2023-11-14 | Merck Patent Gmbh | Polypeptides binding ADAMTS5, MMP13 and aggrecan |
Also Published As
Publication number | Publication date |
---|---|
EP2186894A1 (en) | 2010-05-19 |
JPWO2009008414A1 (ja) | 2010-09-09 |
US8536313B2 (en) | 2013-09-17 |
JP5354680B2 (ja) | 2013-11-27 |
EP2186894A4 (en) | 2010-10-20 |
US20100330092A1 (en) | 2010-12-30 |
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